professor julie quinlivan university of notre dame australia
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Beyond the numbers: Understanding potentially avoidable deaths and the evidence based approaches to prevention. Professor Julie Quinlivan University of Notre Dame Australia University of Adelaide Women’s and Children’s Research Institute Ramsay HealthCare, Joondalup Health Campus. - PowerPoint PPT PresentationTRANSCRIPT
Beyond the numbers: Understanding potentially avoidable deaths and the
evidence based approaches to prevention
Professor Julie QuinlivanUniversity of Notre Dame Australia
University of Adelaide Women’s and Children’s Research InstituteRamsay HealthCare, Joondalup Health Campus
Acknowledgements• Members of the Perinatal and
Maternal Mortality Review Committee• Chair, Professor Cynthia Farquhar• Health Quality and Safety
Commission New Zealand.
Perinatal mortality• Key associations• Potentially avoidable factors• Evidence that may guide a response
Associations with Ethnicity
• Maori and Pacific women– Still birth– Preterm birth– Antepartum haemorrhage– Sudden Unexpected Deaths in Infancy
• NZ European and non-Indian Asian women– Neonatal deaths– Hypertension and diabetes
Increased stillbirth Increased neonatal death
Associations with Socioeconomic Deprivation
Associations with Age* Teenage mothers– Stillbirth– NND – Preterm birth
* Older mothers (>40 years) –Maternal medical conditions– Congenital abnormalities
Associations with Drug and Alcohol Use
• Smoking– Data still incompletely reported (50%)– 35-29% deaths compared to background rate of
14%
• Alcohol and marijuana– Preterm birth– Sudden unexpected deaths in infancy
Associations with Overweight and Obesity
Associations with Twins and multiple
pregnancy
Associations with Family violence, Preterm birth and Small for
Gestational age
Potentially avoidable deaths
Perinatal related deaths (N=704)
Contributory factors
N %
Present 192 27.3%
Absent 497 70.6%
Missing data 15 2.1%
Contributory factor present (N=192)
Potentially avoidable
N %
Yes 124 17.6%
No 66 9.4%
Contributing factors present but avoidability unknown
2 0.31%
Avoidable contributory factors
• Organizational• Personnel• Technology• Environmental• Barrier to care
Organizational factors (N=39)
Delay in procedure (eg C/S) 8Delay in emergency response 5Poor access to senior staff 4Inadequate training/education 4Lack of policies/protocols/guidelines
3
Inadequate staff numbers 3Poor organization of staff 2Other 10
Personnel factors (N=60)
Failure to follow recommended best practice
21
Lack of knowledge and skills 12Poor communication 7Failure to seek help/supervision 5Delayed response by staff 4Other 11
Technology factors (N=5)
Essential equipment not available
1
Lack of maintenance of equipment
1
Malfunction/failure of equipment
1
Other 2
Environmental factors (N=19)
Geography 14Other 5
Barriers to Care factors (N=149)
Lack of recognition of complexity or seriousness of condition
23
Substance Use 16Maternal mental illness 9Family violence 7Language barriers 6Cultural barriers 4Other 84
Barriers to Care - Other (N=84/124)
• No antenatal care• Late booking with antenatal care• Non-attendance with antenatal visits• Not following advice or treatment
Staff education & behaviour
Staffing education/behaviour (N=69/124)
• Lack of recognition of complexity or seriousness of condition (N=23)
• Failure to follow recommended best practice (N=21) • Knowledge and skills of staff were lacking (N=12)• Failure to seek help/supervision (N=5)• Inadequate training/education (N=5)• Lack of policies/protocols/guidelines (N=3)
Discussion points
• Evidence based management of teenage and older mothers
• Evidence base behind staff training and behaviour in obstetrics
• Evidence base behind non engagement with care (talk 2)
The younger mother – Stillbirth– Preterm birth– Neonatal death
What is the evidence base to improve
outcomes for teenage mothers?
The Quinlivan Triad of Care 1. Teenage antenatal clinics2. Home visitation services3. Postnatal re-engagementin education or workforce and parenting support
» Quinlivan JA. Community Paediatric Review 2008; 16: 5-6.
Triad 1: Teenage antenatal clinic
“Teenage-specific antenatal clinics that have comprehensive screening policies for infection and psychosocial pathology are associated with lower rates of preterm birth.”
» Quinlivan JA, Evans SF. BJOG 2004:111; 751-578.
Teenage antenatal clinic careCare is provided by a multi-disciplinary team.CPG includes: – Screening for genital tract infection, anaemia and
other infections (dental, urine)– Social work appraisals (housing, violence, income) – Management plan for illegal drug use, smoking and
alcohol– An open hospital admission policy– Direct linkage to Centrelink.
– Quinlivan JA, Evans SF. BJOG 2004:111; 751-578.
Teenage ANC and Preterm birthTeenage antenatal clinics are associated with reductions in:– TPL – PPPROM– preterm birth
– Quinlivan JA, Evans SF. BJOG 2004:111; 751-578.
Cost of a teenage clinicCost based on N=70
No clinic Teenage clinic
Cost of preterm birth
$122,000 $72,000
Cost of clinic
$0 $51,000
Total $122,000 $123,000Quinlivan JA. Teenage parents – improving their outcomes using evidence based medicine. Working towards closing the gap on Aboriginal and Torres Strait Islander Children and Young People’s Health and Well Being Queensland Government, Queensland Health. Brisbane May 2010.
Triad 2: Home visitation
Meta-analyses and surveys of over 3,000 studies show that nurse home visitation consistently provide the most positive outcomes for vulnerable mothers children both in the short term and sustained over time.
– Karoly LA, Greenwood PW et al. Investing in our children.: RAND Corporation, Santa Monica, CA, 1998
Triad 3: Postnatal parenting programs where childcare is provided.
Findings of a systematic review, based upon 14 studies involving teenage mothers, found that parenting programs can be effective in improving a range of psychosocial and developmental outcomes for teenage mothers and their children.
However, childcare is vital to program success.
Coren E et al, J Adol 2003.
The older mother– Congenital anomalies– Maternal chronic disease
» Loke AY, Poon CF. J Clin Nurs 2011; 20: 1141-50
What is the evidence base to improve
outcomes for older mothers?
Older age and stillbirth
• Systematic review of 31 retrospective cohort and 6 case control studies found that greater maternal age was associated with increased risk of still birth.
• Relative risks vary from 1.20 to 4.53.» Huang L et al. CMAJ 2008; 178: 165-172.
Older age a risk for many adverse outcomes.
• Retrospective study of 45,033 women• Significant linear association documented
between advanced maternal age and:– IUGR, LBW, malformations, perinatal mortality.– Most of the risk driven by
• chronic disease driven preterm birth and IUGR, and• fetal malformations.
» Salem YS et al. Arch Gynecol Obstet 2011; 282: 755-9
Intrapartum anoxia a risk
• Retrospective cohort study of 1,043,002 women with singleton term cephalic infants.
• Compared with women aged 25-34 years, women >35 years had an increased risk of delivery related perinatal death at term– OR 2.20 95%CI 1.42-3.40
• Excess risk explained by intrapartum anoxia– Primip OR 5.34 95%CI 2.34-12.20– Multip 2.14 95%CI 0.99-4.60
» Pasupathy D et al J Epid Com Med 2011; 65: 241-5.
Managing Risk• Excess fetal anomalies needs early
advice of options and screening• Excess medical problems needs early
optimisation of conditions• Excess anoxia in labour needs
appropriate birth plans
To address the evidence, nulliparous women over 35 years of age and parous women over 40 years of age should have a first trimester visit dedicated to discussing:• Screening for
prenatal anomalies • Screening for
chronic disease • A realistic birth plan
is discussed.
Staff training and clinical guidelines
Clinical practice guidelines improve patient care outcomes in obstetrics.Santo S, Ayres-de-Campos O. Crr Opinion Obstet Gynecol 2012; 24(2): 84-8
Berglund A, Leferre-Cholay H, Bacci A et al. Acta Obstet Gynecol 2010; 89: 230-237
Strasser DC, Falconer JA, Stevens AB et al. Arch Phys Dis Rehab 2008; 89(1): 10-5
Clinical Practice GuidelinesObstetric RCT
• Study across three hospitals to review impact of clinical practice guidelines.
• High compliance rate with guidelines• Improvements in all outcome measures
for pregnancy including reduction in PMR.– Berglund A, Leferre-Cholay H, Bacci A et al. Acta Obstet
Gynecol 2010; 89: 230-237
Clinical Practice GuidelinesObstetric RCT
• “Improvements in health outcomes does not require primarily expensive technology. Rather staff must be trained and motivated to adhere to evidence-based routines to prevent unnecessary complications and treat the unavoidable ones.”
– Berglund A, Leferre-Cholay H, Bacci A et al. Acta Obstet Gynecol 2010; 89: 230-237
What is the evidence base behind staff training and persuading staff to follow clinical guidelines?
RCT trials data….• Interactive computer based training is better
than lecture based training– Rosen J, Mulsant BH, Kollar M et al. J Am Med Dir Assoc 2002; 3(5): 291-6
• Multidisciplinary team based training with problem solving and individual performance feedback is better than education based training
– Strasser DC, Falconer JA, Stevens AB et al. Arch Phys Med Rehab 2008; 89(1): 10-5.
• Setting examination benchmarks improves performance in training
– Santo S, Ayres-de-Campos O. Curr Opinion Obstet Gynecol 2012; 24(2): 84-8
In most areas of medicine education and training change clinician practice and improve patients outcomes.
Does this hold true for obstetrics?
Obstetrics appears to be different.
Systematic review of RCT
The systematic review of 33 studies concluded:
In obstetrics, educational strategies with medical providers are generally ineffective;…
audit and feedback with personal reminders, local leadership, and multifaceted strategies are generally effective
» Chaillet N, Dube E, Dugas M et al. Obstet Gynecol 2006; 108: 1234-45
InterestinglyMost healthcare providers in obstetrics require more than just education and trainingThey require* Audit* Personal Feedback* Local leadership.
Audit with personalized feedback
Individual*Can benchmark performance
Hospital/Healthcare authority*Allows outliers to be identified
Role of local leadership
RCTs demonstrate that change in practice that involves more than one category of staff (e.g. doctors and midwives) requires strong and clear local leadership to achieve acceptance and compliance with routines.
» Smith H, Brown H, Hofmeyr GJ, Garner P. S African Med J. 2004: 94: 117-20
» Allery LA, Owen AO, Robling MR, BMJ 1997; 314: 840-7» Rashidian A, Eccles MP, Russel I. Health Policy 2008; 85: 148-61.
Why? Maybe because bad outcomes are rare, and…
• “Most doctors and nurses are convinced that their traditional way of working is effective and good for their patients”
• “It is important to provide not only new guidelines but also in-depth understanding of the rationale for change.”
– Berglund A, Leferre-Cholay H, Bacci A et al. Acta Obstet Gynecol 2010; 89: 230-237
Evidence-based medicine (EBM) and evidence-based decision-making (EBDM) were intended to revolutionize health care and health policy. Thus far they have not. The first step is to reconceive EBM and EBDM as habits of mind rather than a toolbox and to recognize that the sociology of knowledge is as important as its technical content.
Lewis S. J health Serv Res Policy 2007; 12(3): 166-72
“In the field of obstetric care, multifaceted strategy based on audit and feedback and facilitated by local opinion leaders is recommended to effectively change behaviors.”
Chaillet N, Dube E, Dugas M et al. Obstet gynecol 2006; 108: 1234-45
Why do patients
not engage with care?
Next talk!
Summary• Excellent results.• More work on managing the
extremes of reproductive age.• More work on staff development in a
format that elicits positive behavioural change.
Thankyou