Schedule

9/17- Tissue Practicum, Tissue Drawings Due9/18- Integ Notes; Lab activity (End 1st 6 wks)

9/21- Finish Integ Notes, Finish Lab 9/22- Integ. Lab Due, Disease & Disorder Lecture9/23- Case Studies Whatya have? Whatya have?9/24- Review for Test9/25- Tissue/Integumentary Test (coloring

due)

9/28- Intro to Bones, Bones Lab9/29- Intro to Bones (contd), Bones Lab9/30-10/1-10/2- Vocab 4 & 5 Quiz

Integumentary System

Chapter 5 in your textbook

The Skin

•Waterproof, stretchable, washable, repairs small rips, cuts and burns

•The skin and the associated organs of sweat and oil glands, hairs, and nails make up the Integumentary system

Fun Facts

• Consists of Skin, Hair, Nails, and Glands

• Avg. makes up about 9-11 lbs. or 7% of your weight

• Regenerates every 25-45 days

Structure• Epidermis: Stratified squamous

epithelium that is keratinized• Dermis: Dense fibrous connective tissue• A burn or friction causes a separation of

the layers : blister• Hypodermis or superficial facia:

subcutaneous tissue; adipose tissue: anchors skin to underlying organs. Shock absorber, insulator

Skin Anatomy AKA Cutaneous Membrane consists of:

epidermis (epithelial) dermis (fibrous) subcutaneous layer (fat) hypodermis

Epidermis• (keratinocytes & melanocytes); avascular; “tissue layer above

skin”; stratified squamous epithelium; BARRIER LAYERFive layers:• Stratum corneum: “horny” layer; dead stratified squamous; look

rough; keratin present (water-repellent protein); can become thick from irritation (callus)

• Stratum lucidum: “clear” layer; dead cells• Stratum granulosum: “granular” layer; thin; cells dying; begin

keratinization (cells move up)• Stratum spinosum: “spiny” layer; protein synthesis with RNA to

generate keratin; living cells• Stratum basale: “base” layer; AKA stratum germinativum; rapid

mitosis; youngest cells; melanin (pigment protects from UV light);

NOTE:

• Thick skin- covers palms, fingertips, soles of feet

• Thin skin – covers rest of body– missing stratum lucidum and sometimes stratum

granulosum

Cells of the Epidermis

• Keratinocytes, melanocytes, Merkel cells and Langerhan’s cells

• Majority of the cells are keratinocytes– Produce keratin, a fibrous protein: protective– Connected by desmosomes and arise in the

stratum basale layer until they rich the outer surface where the dominate the cells content. Here they are dead, scale-like structures

– We shed our skin every 25-45 days

Epidermis• Stratum basale:deepest

layer; contains the only epidermal layer that receive adequate nourishment via diffusion from the dermis

• Cells constantly undergoing mitosis: stratum germinativum

Dermis: True Skin

Contains sensory receptors for pain, pressure, touch, and temperature; vascular; forms basement membrane

• Papillary Layer- thin; projections of collagen and elastin into basement membrane; areolar tissue; elastic fibers ex. fingerprints

• Reticular Layer- “skin network”; thick; dense fibrous connective tissue; elastic fibers (stretchable); arrector pili muscles (attach to hair follicle & contract when cold); stretch marks (tears of elastic fibers)

Papillary Layer

Thin superficial areolar connective tissue with collagen and elastin fibers

Superior surface appears as peg like projections called dermal papillae that indent the epidermis

House Meissner’s corpuscles (touch receptors); pain receptors and capillary loops

Reticular Layer

80 % of the dermal thickness is dense irregular tissue

Contains blood vessels, sweat and oil glands

Deep pressure receptors (Pacinian corpuscles)

Phagocytes: prevent bacteria from penetrating to deeper body layers

II. SKIN COLOR• GENETICS is the key factor• Quantity of melanin

– (yellow to reddish- brown to black)– protects skin from UV radiation

• In melanocytes, use enzyme tyrosinase to convert tyrosine into dark brown melanin pigment, albinos lack DNA code to make tyrosinase

• sunlight increases melanin production by affecting release of hormones

• freckles or moles are accumulations of melanin• other pigments such as carotene or hemoglobin

contribute to skin color

SKIN ColorThree pigments :

1.The amount and kind of melanin (yellow, reddish brown or black)2.The amount of carotene deposited in the stratum corneum and subcutaneous tissue3. The amount of oxygen bound to hemoglobin

SKIN ColorFreckles and pigmented moles are large accumulations of melanin

Melanoctyes are stimulated when the skin is exposed to sunlight

Prolonged exposure causes substantial melanin buildup which helps protect the DNA of viable skin cells from UV radiation by absorbing the light and dissipating the energy as heat

Hair: aka pilicovers all of humans

EXCEPT palms of hands, soles of feet, lips, nipples some genitalia

1. Hair follicle- shaft, root, medulla (inner), cortex (outer), cuticle (cover)

2. Growth- 4 in./year or 2 mm/week; male-pattern

baldness- genetic, sex-influenced, hormones (testosterone)

Nails• Consists of:

– free edge– Body– Root– Cuticle– Lunula– keratin

• growth- 0.5 mm/week• fingernails faster than

toe nails – blood flow?

Skin Glands1. Sweat Glands- AKA sudoriferous;

found in palms, feet, forehead (perspiration/ sweat – 99% water) or found in axillary and anogenital regions – milky color

2. Sebaceous Glands- in dermis; secrete sebum oil for hair and skin; 2/hair; antifungal; antibacterial

3. Ceruminous Glands- cerumen or earwax; can block ear from insects

Sebaceous (Oil) Glands• Found all over except on the soles and palms• Holocrine glands; ducts usually empty into a hair follicle• Sebum: mixture of oily substances and fragmented cells;

acts as a lubricant that keeps skin soft and prevents the hair from becoming brittle; contains chemicals that kill bacteria

Sweat (Sudoriferous) Glands• Two types: eccrine and apocrine

1. Eccrine/merocrine glands: sweat: clear secretion primarily water, salts

2. Apocrine: axillary and genital areas; Secretion contains fatty acids and proteins, as well as the eccrine substances; can appear milky-white or yellow

Skin PhysiologyA. Protection: from microorganisms, chemicals, physical injury,

dehydration, UV lightB. Sensation: receptors C. Excretion: sweat contains uric acid, ammonia, urea, salt,

waterD. Metabolism: Vitamin D production by absorbing UV lightE. Immunity: T cells, Langerhans cells, and macrophages found

in the skin to fight microorganismsF. Temperature Regulation: varies from 37.6oC to 36.2oC; heat

produced comes from metabolism in muscles and glands; heat is lost if blood vessels widen (vasodilation); heat is saved if blood vessels constrict (vasoconstriction); regulated by hypothalamus