sÃo francisco university

S Ã O F R A N C I S C O U N I V E R S I T Y

P O S T - G R A D U A T I O N I N H E A L T H S C I E N C E

The Health Science postgraduate program from São Francisco University directs the education of the student to carry out Sci-ence in an interdisciplinarity nature. The graduate student will have a glimpse of a critical view of science and will be contextu-alized in training based on scientific evidence, focused mainly on laboratory findings and their importance to the field of health and patient care.

The Program aims to provide continuing education for teachers and researchers with a high level of training in basic and applied medicine. The course has a range of disciplines in both virtual and presential learning environments to contemplate the sce-nario of interdisciplinarity. Our objective is to train professionals capable of answering scientific questions of social relevance with quality and confidence.

The mission of the Health Science Postgraduate Program led to the creation of a multidisciplinary course themed in specific areas of knowledge, employing complementary lines of active and productive research. The target audience is medical doc-tors, physiotherapists, biologists, biomedical doctors, nurses, pharmacists, chemists, psychologists, nutritionists, physical edu-cators, dentists, and statisticians. The master’s (M.Sc.) degree course has a duration of 12 to 24 months while the doctorate (Ph.D.) has a duration of 24 to 60 months.

Q U A L I T Y T R A I N I N G F O R

H E A L T H P R O F E S S I O N A L S

S I N C E 2 0 0 6

Whether you're interested in starting the Health Science Postgraduate Pro-gram as a new student, an application is required. Application admission is a multistep process:

• Make contact with one of the professors of the Health Science Postgraduate Program

• Complete the online application form• Pay the application fee• Submit transcripts and documentation• Present a research project• Submit test scores: International students applying to the Health Science

Postgraduate Program must submit either an official Test of English as a For-eign Language (TOEFL) or International English Language Testing System (IELTS) score report demonstrating an adequate knowledge of English.

Evaluation and conferral of degree to be evaluated and be conferred with the degree, the candidate will need to:

• Have completed the required courses and completed the credits required by the program;

• Have completed the qualification exams, being two for M.Sc and one for Ph.D. degrees.

• Present proof of the acceptance of a full article by an internationally circulat-ing journal indexed by SCI, describing the contents of the Thesis.

H O W T O A P P L Y

L I N E S O F R E S E A R C H A N D L E C T U R E R S / F A C U L T Y / O R C I D

GENERAL AND CLINICAL PHARMACOLOGY

Giovanna Barbarini [email protected] | www.orcid.org/0000-0001-5828-8957

Line of Research: Bioprospecting for natural compounds and bioactive derivatives with potent anticancer activityGraduated in Biological Sciences (UNIFAL). Master and Ph.D. in Cellular and Structural Biology (Uni-camp). Postdoctoral at the Research Center in Molecular Oncology (Barretos Cancer Hospital). She works on the bioprospection of potential anticancer compounds isolated from natural sources (microorganisms, plants, and marine animals) and on the study of the signaling pathways involved in cell death processes.

Article: M Franco YE, Y Okubo M, D Torre A, P Paiva P, N Rosa M, O Silva VA, M Reis R, T G Ruiz AL, M Imamura P, de Carvalho JE, B Longato G. Coronarin D induces apoptotic cell death and cell cycle arrest in the human glioblastoma cell line. Molecules. 2019;24(24):4498.

Juliana Mozer [email protected] | www.orcid.org/0000-0001-7213-206X

Line of Research: Discovery and development of new drugs from animal's venoms and medicinal chemistryGraduated in Biological Sciences (UMESP), Master in Pharmacology (UNIFESP), Ph.D. in Biotechnol-ogy (USP), and Postdoctoral at Instituto Butantan. Acts in research and innovation projects involv-ing the discovery of new molecules from marine animals, focusing on drug development for neuro-degenerative diseases, cancer, and infections, using biochemical methods and medicinal chemis-try tools.

Article: Coelho GR, Prezotto Neto, P, Barbosa FC, Santos RS, Brigatte P, Spencer PJ, Sampaio SC, Damelio F, Pimenta DC, Sciani, JM. Biochemical and biological characterization of the Hypanus americanus mucus: a perspective on stingray immunity and toxins. Fish Shellfish Immunol. 2019;93:832-840.

Raquel de Cássia dos [email protected] | www.orcid.org/0000-0002-7117-0651

Line of Research: Bioprospecting of natural products for therapeutic purposes in the face of gastrointestinal disordersGraduated in Biological Sciences (UNESP), Ph.D. in Pharmacology (UNESP), Postdoctoral at São Francisco University (USF), with experience in preclinical research in the field of Natural Products, acting mainly on the following themes: development of natural products derived from plants aimed at human health for therapeutic purposes in the face of gastrointestinal disorders such as peptic ulcer, intestinal mucositis, and inflammatory bowel disease.

Article: Fagundes FL, de Morais Piffer G, Périco LL, Rodrigues VP, Hiruma-Lima CA, Dos Santos RC. Chrysin Modulates Genes Related to Inflammation, Tissue Remodeling, and Cell Prolifera-tion in the Gastric Ulcer Healing. Int J Mol Sci. 2020;21(3):760.

Patrícia de Oliveira Carvalho [email protected] | www.orcid.org/0000-0002-2681-7022

Line of Research: Biocatalysis and biochemistry of lipidsGraduated in Biochemical Pharmacy (UNIFAL), MSc, and Ph.D. in Food Engineering (Unicamp). She supervised more than 20 postgraduate students. Acts on two different research lines: (1) enzymatic modification and characterization of new biomolecules for application in the pharmaceutical and food industries and (2) mass spectrometry-based pharmacometabolo-mic and lipidomic applied to different diseases.

Article: Uyeda M, Duarte GHB, de Piloto Fernandes AMA, Contesini FJ, Messias MCF, de Santis GKD, Barros KV, Simionato AVC, de Oliveira Carvalho P. Bio-synthesized sardine oil concen-trate alters the composition of hepatic lipids in rats: A lipidomic approach. Food Res Int. 2020;130:108874.


GENERAL AND CLINICAL PHARMACOLOGY

Fábio Henrique da [email protected] | www.orcid.org/0000-0003-3374-5570

Line of Research: Priapism and voiding dysfunction in sickle cell disease: pathophysiology and new drug candidatesGraduated in Pharmacy, MSc, and Ph.D. in Pharmacology (Unicamp). Postdoctoral at The Johns Hopkins University School of Medicine (Baltimore, USA), and at the Center of Hematolo-gy and Hemotherapy (Unicamp). His research interests include drug discovery, pharmacology of erectile dysfunction, priapism, and lower urinary tract symptoms.

Article: Musicki B, Anele UA, Campbell JD, Karakus S, Shiva S, Silva FH, Burnett AL. Dysregulated NO/PDE5 signaling in the sickle cell mouse lower urinary tract: Reversal by oral nitrate therapy. Life Sci. 2019;238:116922.

Daniela Soares [email protected] | www.orcid.org/0000-0002-2217-0946

Line of Research: Metabolic and molecular processes involved in the physiopathology of obesityGraduated in Biological Sciences, MSc in Pathophysiology and Ph.D. in Science (Unicamp). Post-doctoral at Obesity and Comorbidities Research Center (Unicamp) and at the University of Cam-bridge, UK. Acts in the obesity field, investigating metabolic and hypothalamic molecular pro-cesses involved in the physiopathology of diet-induced obesity and comorbidities.

Article: Razolli DS, Moura-Assis A, Bombassaro B, Velloso LA. Hypothalamic neuronal cellular and subcellular abnormalities in experimental obesity. Int J Obes (Lond). 2019;43(12):2361-2369.

Mário Angelo Claudino [email protected] | www.orcid.org/0000-0002-3590-9607

Line of Research: Cardiovascular disease drug therapy and pharmacologyGraduated in Pharmacy, Ph.D. in Pharmacology (Unicamp). Postdoctoral at Pharmacology (Unicamp), Louisiana State University Health Sciences Center (New Orleans, USA) and at the University of South Florida (Florida, USA). Acts in the cardiovascular pharmacology field, with emphasis on the discovery of new treatments, experimental models development for cardio-vascular diseases, endothelial function and dysfunction, and lower urinary tract symptoms.

Article: Mora AG, Furquim SR, Tartarotti SP, Andrade DR, Janussi SC, Krikorian K, Rocha T, Fran-co-Penteado CF, Priolli DG, Priviero FBM, Claudino MA. Progression of micturition dysfunction associated with the development of heart failure in rats: Model of overactive bladder. Life Sci. 2019;226:107-116.


INTERDISCIPLINARY STRATEGIES IN EXPERIMENTAL RESEARCH APPLIED TO DISEASES

Lúcio Fábio Caldas [email protected] | www.orcid.org/0000-0002-3818-3215

Line of Research: Molecular mechanisms regulating virulence gene expression in pathogenic bacteriaBachelor’s degree in Biological and Biomedical Science at Universidade Estadual de Campinas (Unicamp, Brazil). MSc in Molecular Biology and Genetics (Unicamp), Sandwich Ph.D. at Unicamp and the University of Southern California (USA), also in Molecular Biology and Genetics, and post-doctoral at Unicamp. He has experience in the field of Molecular Genetics, with an emphasis on Human and Bacterial Genetics. Currently, leads research projects that focus on understanding the mechanisms that regulate gene expression.

Article: Gomes AÉI, Stuchi LP, Siqueira NMG, Henrique JB, Vicentini R, Ribeiro ML, Darrieux M, Ferraz LFC. Selection and validation of reference genes for gene expression studies in Klebsiella pneu-moniae using Reverse Transcription Quantitative real-time PCR. Sci Rep. 2018;8(1):9001.

Michelle Darrieux Sampaio [email protected] | www.orcid.org/0000-0002-7829-3435

Line of Research: Bacterial virulence factors as vaccine candidatesGraduated in Biological Sciences, Ph.D. in Biotechnology (USP), and postdoctoral at Butantan Institute and at Lund University. Acts on understanding how bacteria evade the host immune re-sponses during colonization and disease, and on identifying novel vaccine candidates, which are tested for their immunogenicity and protective potential in vitro and in vivo.

Article: André GO, Assoni L, Rodriguez D, Leite LCC, Dos Santos TEP, Ferraz LFC, Converso TR, Darrieux M. Immunization with PhtD truncated fragments reduces nasopharyngeal colonization by Streptococcus pneumoniae. Vaccine. 2020;38(26):4146-4153.

Raquel [email protected] | www.orcid.org/0000-0002-7117-0651

Line of Research: Bacterial microbiome and antimicrobial resistanceGraduated in Biology (Universidade de Passo Fundo), MSc in Microbiology (Universidade Estadual de Londrina), and Ph.D. and Postdoctoral in Infectology at Universidade Federal de São Paulo. Acts in clinical microbiology, on the characterization of antimicrobial resistance mechanisms and in the development of laboratory tools for the evaluation of susceptibility antimicrobial tests.

Article: Girardello R, Cury AP, Franco MRG, Di Gióia TR, de Almeida JN Jr, de Araújo MRE, da Silva Duarte AJ, Rossi F. Colistin susceptibility testing and Vitek-2™: is it really useless? Diagn Microbiol Infect Dis. 2018;91(4):309-311.

Thais Manzano [email protected] | www.orcid.org/0000-0003-3719-6062

Line of Research: Early childhood caries: etiological factors, preventive aspects and relationship with other diseasesGraduated in Dentistry (State University of São Paulo - Júlio de Mesquita Filho - UNESP), Master and Ph.D. in Pediatric Dentistry (State University of Campinas/FOP-Unicamp), sandwich program Ph.D. at the Forsyth Institute (USA). Acts in observational clinical studies involving a multifactorial approach to early childhood caries; assessment of clinical parameters of carious lesions relating to the microbiological and biochemical composition of dental plaque, immunological factors of saliva, diet, and oral hygiene.

Article: Indiani CMDSP, Rizzardi KF, Castelo PM, Ferraz LFC, Darrieux M, Parisotto TM. Childhood obesity and firmicutes/bacteroidetes ratio in the gut microbiota: a systematic review. Child Obes. 2018;14(8):501-509.



Denise Gonçalves [email protected] | www.orcid.org/0000-0003-3190-4013

Line of Research: Cancer - prospecting new targets and therapiesPhysician (UMC), MSc in Surgery (IAMSPE), Ph.D. in Medical Science (UNIFESP), and postdoctoral at the Institute of Biophysics of Coimbra University, Portugal. Acts in two different research lines: (1) analyzing molecular mechanisms associated with colon carcinogenesis, and (2) study-ing compounds with potential anti-tumoral effects, analyzing their mechanisms of action through in vitro and in vivo studies.

Article: de Oliveira CTP, Colenci R, Pacheco CC, Mariano PM, do Prado PR, Mamprin GPR, San-tana MG, Gambero A, de Oliveira Carvalho P, Priolli DG. Hydrolyzed rutin decreases worsening of anaplasia in glioblastoma relapse. CNS Neurol Disord Drug Targets. 2019;18(5):405-412.

Andreia de Melo [email protected] | www.orcid.org/0000-0003-4244-8594

Line of Research: Metabolomics using mass spectrometry technologies for cancer diagnosis and health related researchChemist with a background in Analytical Chemistry, with MSc and Ph.D. in Analytical Chemistry (Unicamp). Acts at investigating new diagnostics methods for different cancers types (such as breast, cervix, and brain) and other diseases, using classical metabolomics (LC-MS/MS, GC-MS/MS) and recent ambient imaging MS techniques.

Article: Silva AAR, Cardoso MR, Rezende LM, Lin JQ, Guimaraes F, Silva GRP, Murgu M, Priolli DG, Eberlin MN, Tata A, Eberlin LS, Derchain SFM, Porcari AM. Multiplatform investigation of plasma and tissue lipid signatures of breast cancer using mass spectrometry tools. Int J Mol Sci. 2020;21(10):3611.

Fernando Augusto de Lima [email protected] | www.orcid.org/0000-0003-4955-4234

Line of Research: Molecular biology and epidemiology in respiratory diseases Graduated in Biological Sciences (UNESP); MSc and Ph.D. in Science (Unicamp), Postdoctoral at the Genomic and Medical Genetics Laboratory (Unicamp), and at Lisbon University, Lisbon. Acts in the epidemiological and genetics field, investigating the phenotype and genotype from the respiratory system for healthy individuals and for lung diseases. Article: Palamim CVC, Marson FAL. COVID-19: the availability of ICUs in Brazil during the onset of pandemic. Ann Glob Health 2020;86(1):1-15.


Manoela Marques [email protected] | www.orcid.org/0000-0003-4609-7074

Line of Research: Cellular and molecular biology in Neuro-oncology diseasesGraduated in Biological Sciences (UNESP); MSc and Ph.D. in Molecular Biology in Onco-He-matological Diseases at the Center of Hematology and Hemotherapy (Unicamp); Postdoc-toral at Kansas University Medical Center and at the University of Health Science Center at San Antonio, Texas. Acts on two research fields: 1) single nucleotides variants and microR-NAs on the inflammation process in Neurooncology and 2) microRNAs involved in natural compounds with the potential anti-tumoral effect in vitro and in vivo.

Article: Bonafé GA, Dos Santos JS, Ziegler JV, Umezawa K, Ribeiro ML, Rocha T, Ortega MM. Growth Inhibitory Effects of Dipotassium Glycyrrhizinate in Glioblastoma Cell Lines by Tar-geting MicroRNAs Through the NF-κB Signaling Pathway. Front Cell Neurosci. 2019;13:216.

Marcelo Lima [email protected] | www.orcid.org/0000-0003-4529-7832

Line of Research: Cellular and molecular biology in Neuro-oncology diseasesBiologist (PUC) with an M.Sc in Medical Sciences and Ph.D. in Pharmacology (both at Unicamp), postdoctoral at Biodonostia Institute, Spain, Vall d'Hebron Institute of On-cology, Spain and Josep Carreras Leukaemia Research Institute, Spain. Acts on two different research lines: (1) analyzing molecular mechanisms associated with gastric carcinogenesis with an emphasis in oxidative stress, DNA repair mechanisms, epi-genetic regulation, and cancer stem cells, and (2) studying compounds with poten-tial anti-adipogenic effect, analyzing the mechanisms of action in vitro and in vivo.

Article: Lima NDS, Caria CREP, Gambero A, Ribeiro ML. The effect of Guarana (Paul-linia cupana) on metabolic and inflammatory parameters in adult male mice pro-grammed by maternal obesity. Eur J Nutr. 2019;58(2):765-774.


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