sssc retreat.bioinfo resources.20110411

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Sean Davis, M.D., Ph.D. Genetics Branch, Center for Cancer Research National Cancer Institute National Institutes of Health Bioinformatics Resources An Incomplete List April 11, 2011, SS/SC Retreat

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Ten minute talk to the Staff Scientist and Staff Clinicians from NCI regarding bioinformatics resources.

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Page 1: Sssc retreat.bioinfo resources.20110411

Sean Davis, M.D., Ph.D.Genetics Branch, Center for Cancer Research

National Cancer InstituteNational Institutes of Health

Bioinformatics ResourcesAn Incomplete List

April 11, 2011, SS/SC Retreat

Page 2: Sssc retreat.bioinfo resources.20110411

Normal Karyotype

Tumor Karyotype

Page 3: Sssc retreat.bioinfo resources.20110411

The Central Dogma

Page 4: Sssc retreat.bioinfo resources.20110411

phenotype

Gene Copy Number

Sequence Variation

Chromatin Structure

and Function

Gene Expression

Transcriptional Regulation

DNA Methylation

Patient and Population

Characteristics

Page 5: Sssc retreat.bioinfo resources.20110411

Overview

Hardware

Software

Online databases

Training and Education

Getting Answers

Page 6: Sssc retreat.bioinfo resources.20110411

Hardware

Computers Current desktops quite capable High-performance resources

Helix/Biowulf (CIT) Advanced Biomedical Computing Center (ABCC) Amazon EC2

Storage Local storage Helix/Biowulf NCI group drives

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Software

Commercial

Open Source

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Software

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Software

Bioconductor

Bio-[Python, Java, Ruby, Perl]

BRB ArrayTools

GenePattern

And the list goes on….

Page 10: Sssc retreat.bioinfo resources.20110411

Software

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Online Databases

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Online Databases

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Training and Education

Google

CIT/Helix training http://training.cit.nih.gov

NIH Library http://nihlibrary.nih.gov/ResearchTools/Pages/

Bioinformatics.aspx

Cold Spring Harbor, AACR, OpenHelix, BioConductor, ….

Page 14: Sssc retreat.bioinfo resources.20110411

Getting Answers

Google

http://seqanswers.com/

http://biostar.stackexchange.com/

http://bioinformatics.nci.nih.gov/

CCR Bioinformatics Core http://ccrifx.cancer.gov/

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Contact and Acknowledgements