Research Forum-Child Health Team MembersJune 2014

Regular Team Members:

1. I rving Boime, PhD Professor Depts. of Developmental Biology andObstetrics and Gynecology

2. Steven L. Brody, MD Professor of Medicine3. Vikas R. Dharnidharka, MD, MPH Division Director, Pediatric Nephrology4. Mary C. Dinauer, MD, PhD Scientific Director, Children’s Discovery Institute5. Ann M. Doyle, RN Director Outpatient Research6. Richard Head, MS Associate Professor of Genetics,

Director of GTAC7. Paul W. Hruz, MD, PhD Associate Professor of Pediatrics and Cellular

Biology and Physiology8. Sanjay Jain, MD, PhD Associate professor of Medicine, Renal Division9. John J. Kotyk, BS, MS, PhD Associate Professor,

Assoc. Director Human Imaging Unit10. Leslie D. McIntosh, BA, MPH, PhD Assistant Professor, Pathology and

Immunology11. Robert C. McKinstry, MD, PhD Radiologist-in-Chief, St. Louis Children's Hospital12. Kelle H. Moley, MD Professor and Vice Chair of Obstetrics and

Gynecology13. Margaret A. Olsen, BS, MPH, PhD Associate Professor of Medicine14. Ken B. Schechtman, BS, MS, PhD Associate Professor of Biostatistics

Associate Professor of Medicine15. Shalini Shenoy, MD Professor of Pediatrics

Medical Director, Pediatric Stem Cell Transplant 16. Mark A. Watson, BA, MD, PhD Associate Professor, Pathology and Immunology17. Feliciano Yu, BS, MD, MS Chief Medical Information Officer, St. Louis

Children's Hospital18. Neil White MD, CDE Professor of Medicine and Pediatrics19. Yi Zhang, JD, RN Assistant Dean for Clinical Trials

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Research Forum-Child Health Team MembersJune 2014

Backup/Ad Hoc Members:

1. Dennis J. Dietzen Associate Professor of Pediatrics and Pathology & Ad Hoc Immunology Medical Director, Core Laboratory

2. Allan Doctor, MD Associate Professor of Biochemistry & Molecular Ad Hoc Biophysics, Associate Professor of Pediatrics

Director, Division of Pediatric Critical Care Medicine3. Brad Evanoff Dr. Richard A. and Elizabeth Henby Setter Professor of

K. Moley Backup Occupational, Industrial, and Environmental Medicine, Director, Institute of Clinical and Translational Science,Assistant Dean for Clinical and Translational Research

4. Jane Garbutt, MD Professor of Medicine and Pediatrics, Medical Director,Ad Hoc WU PAARC

5. Brian Hackett, MD, PhD Professor of PediatricsAd Hoc

6. Mary E. Hartman, MD Assistant ProfessorM. Olsen Backup Division of Critical Care Medicine

7. Robert Hayashi, MD Professor of PediatricsAd Hoc Director Director, Division of Pediatric Hematology/Oncology

8. Marc Haynes, RN Nurse Manager, Pediatric Clinical Research UnitN. White Backup

9. Mike Heinz, BS Assistant Director of GTACR. Head Backup

10. Judith Lieu, MD, MSPH Associate Professor of Otolaryngology – Head and NeckAd Hoc Director Associate Residency Program

11. Phil Miller, BA Professor of BiostatisticsK. Schechtman Backup

12. Mukesh Sharma, PhD Biomedical Informatics Project ManagerL. McIntosh Backup

13. Joshua S. Shimony, MD, PhD Assistant Professor, Director, Spine Interventional Ad Hoc Service, Director, CT Imaging Service

14. Phillip Tarr, BA, MD Melvin E. Carnahan Professor of Pediatrics, M. Dinauer Backup/Ad Hoc Professor of Molecular Microbiology

15. Brad Warner, MD Jessie L. Ternberg, MD PhD Distinguished Professor ofAd Hoc Pediatric Surgery, Pediatric Surgeon-in-Chief,

St. Louis Children’s Hospital16. David B. Wilson, MD, PhD Associate Professor of Pediatrics and

P. Hruz Backup and Developmental Biology17. Mary Uhlmansiek Adoption Manger, Clinical Research Data

L. McIntosh Backup

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Research Forum-Child Health Team MembersJune 2014

Regular Team Members:

Irving Boime, PhD, Professor Depts. of Developmental Biology and Obstetrics and GynecologyEmail, Website Back to top

Institution: Washington University in St. Louis (WU)Expertise: Molecular endocrinology; Structure activity relationships of pituitary peptide hormones; Protein secretion/sorting; development of biotechnology patents and multiple commercial license agreements.  Area of Clinical or Research Interest:   Our primary research interest was the

expression of gonadotropin hormone genes of the pituitary.  Our work also focused on the post-translational processing of the hormones coupled to their secretion and sorting. In the course of these investigations analogs were developed that are currently being used therapeutically.

Steven L. Brody, MD, Professor of Medicine Back to topEmail, Website

Institution: Washington University in St. Louis (WU) Expertise: Pulmonary, critical care, gene regulation, developmental biology, nanomaterials, epithelial cellsArea of Clinical or Research Interest: I have experience in both basic-translational (T1) and clinical research. My clinical research experience is primarily in critical care medicine. Our T1 research includes aspects of lung biology in chronic and acute airway disease are our major area of work. We focus on mechanisms of airway epithelial cell differentiation that characterize lung diseases such as asthma, chronic obstructive lung disease,

bronchitis, bronchiectasis, post lung transplant bronchiolitis, respiratory virus and bacterial infection. We are particularly interested in mechanisms of ciliated cell differentiation and cilia biogenesis. These studies are linked to investigation of the genetic basis of lung disease in patient populations with known or suspected defects in cilia, co-called ciliopathies. Our methods utilize both animal models and human samples. Approaches involve techniques in cellular, molecular, and development biology and also employ genetic methods in human and mouse analyses. We have additional projects focused on gene therapy and related approaches, using viral vectors and non-viral nanoparticles for nucleic acid delivery and lung imaging in collaboration with colleagues in radiology.

Vikas R. Dharnidharka, MD, MPH, Division Director, Pediatric Nephrology Back to topEmail, Website

Institution: Washington University in St. Louis (WU)Expertise: Pediatrics, nephrology, transplantation, epidemiologyArea of Clinical or Research Interest: I am a patient-oriented researcher with interests in chronic renal failure, pediatric kidney transplantation and post-transplant infections. I perform epidemiological analyses of very large national databases to elucidate risk factors for events and the outcomes after events, typically infectious events. These large databases include UNOS, USRDS, NAPRTCS. I also participate in multi-center clinical and mechanistic research trials in the areas of chronic renal insufficiency, dialysis and

transplantation. My work gets funding from NIH institutes (NIDDK, NIAID) and industry. I am particularly known for my work related to a post-transplant malignancy called post-transplant lymphoproliferative disorder (PTLD), caused in most cases by Epstein-Barr virus infection. These issues of infection and malignancy post-transplant have received a lot of attention as we gave our patients more immunosuppression in the hopes of

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Research Forum-Child Health Team MembersJune 2014

reducing acute rejection rates. My collaborators are numerous. For the prospective clinical trials, my collaborators include pediatric nephrology colleagues at various centers such as Harvard, Johns Hopkins, University of Pennsylvania, UCSF, University of Washington and UAB. For my epidemiological studies, I collaborate with an adult nephrologist in the Army, with biostatisticians and epidemiologists at Emmes Corporation and with a biostatistician at UNOS.

Mary C. Dinauer, MD, PhD, Professor of Pediatrics, Scientific Director, Children’s Discovery Institute  Email, Website Back to top

Institution: Washington University in St. Louis (WU) Expertise: Hematology, neutrophil, inflammation, innate immunity, NADPH oxidaseArea of Clinical or Research Interest: I have been an NIH-funded investigator since 1991. My research focuses on the regulation of oxidant production by the phagocyte NADPH oxidase, its role in innate immunity and inflammation and inherited defects in Chronic Granulomatous Disease (CGD), where we recently identified a new genetic subgroup of this disorder. The NADPH oxidase is increasingly recognized to have immunomodulatory functions in addition to its role in microbial killing. My laboratory is investigating the regulation and assembly of NADPH oxidase in phagocytic leukocytes, its

role in innate immunity and inflammation, inherited defects in CGD, and strategies for treatment of CGD by gene modification of hematopoietic stem cells. We have developed both a human myeloid cell line model and mouse model of X-linked CGD using gene targeting for use as pre-clinical model systems, in addition to studies in human neutrophils and marrow cells from healthy controls and patients with CGD.

Ann M. Doyle, RN CCRC, Director of Outpatient Research

Email Back to topInstitution: Washington University in St. Louis (WU) Expertise: Hematology, neutrophil, inflammation, innate immunity, NADPH oxidaseArea of Clinical or Research Interest: I have been coordinating clinical trials for more than 15 years; my area of was primarily Inpatient ICU trials along with outpatient pulmonary clinical trials. My experience ranges from Procedural, to budgeting, to regulatory to mentoring. In addition I currently am the director of the outpatient research facility in the CAM, providing research space, support for researchers/ coordinators here at the university. We support a great deal of Phase I cancer trials along with Phase II, III  rheumatology, neuromuscular, pulmonary, gastroenterology,

psychiatry, solid organ transplant among other disciplines. Our goal is to provide dedicated space and personnel for researchers for industry, departmental, and NIH sponsored trials.

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Research Forum-Child Health Team MembersJune 2014

Richard Head, MS, Research Associate Professor of Genetics Back to topEmail, Website

Institution: Washington University in St. Louis (WU) Expertise: Genomics, Inflammation & Immunology, Drug Development, Computational BiologyArea of Clinical or Research Interest: 17 years in pharmaceutical/medical research.  Currently the director of the Genome Technology Access Center (GTAC) and director of R&D for Genomics and Pathology Services (GPS). My lab at Pfizer was focused on all aspects of research in inflammation & immunology from new target discovery to translational/clinical research with the use of multiple ‘omics technologies and

computational biology. Two of our major achievements were the determination of the mode of action of the recently approved Xeljanz (JAK inhibitor) and the development of an extremely sophisticated and detailed molecular/cellular level model of Rheumatoid Arthritis. Since returning to Washington University two years ago, it has been my goal to apply those translational/clinical learnings more broadly through the GTAC and GPS in multiple areas of disease research. Most recently we have successfully moved multiple cutting edge assays from the research space to use in patient care and clinical trials.Resources: GTAC, Genomics and Pathology Services

Paul W. Hruz, MD, PhD, Associate Professor of Pediatrics and Cellular Biology and PhysiologyEmail, Website Back to top

Institution: Washington University in St. Louis (WU) Expertise: Diabetes, HIV, Protein structure/function, Drug design, Membrane transportersArea of Clinical or Research Interest: Dr. Hruz is board certified in Pediatrics and Pediatric Endocrinology and Metabolism. Dr. Hruz has clinical interest in a wide range of endocrine disorders, with a special interest in diabetes mellitus. His research efforts are directed toward understanding facilitative glucose transport as it relates to normal and disordered glucose homeostasis. The laboratory is investigating the in vitro and in vivo effects of HIV protease inhibitors on glucose transporter function. The goal of this research is to identify the molecular mechanisms that lead HIV infected patients receiving

PIs to develop insulin resistance. The laboratory is also using these isoform-selective antagonists of the insulin-responsive transporter GLUT4 to understand the role of glucose transport in insulin-responsive tissues. Recent efforts have been directed toward understanding the role of glucose transport in the failing heart. This has led to translational research into the understanding of the influence of insulin resistance in pediatric heart failure.

Sanjay Jain, MD, PhD, Associate professor of Medicine (Renal Division), Pathology & Immunology; Director-Kidney translational Research Core

Email, Website Back to topInstitution: Washington University in St. Louis (WU) Expertise: molecular genetics, translational research, kidney and urological disease researchArea of Clinical or Research Interest: Our overall interest is to delineate molecular signals that regulate normal development, injury and regeneration of the genitourinary system. We use glial cell line-derived neurotrophic factor (GDNF) family ligands-Ret receptor tyrosine kinase signaling system as a paradigm. This signaling system is associated with a number of human diseases including developmental abnormalities,

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Research Forum-Child Health Team MembersJune 2014

neurodegenerative diseases and cancer syndromes. Using genetically defined Ret signaling mutants we have identified molecular basis for signaling specificity in the development of urogenital system and autonomic nervous system.  A major area of interest is renal and urinary tract malformations and gene-environment interactions between the GU and the peripheral nervous system.  To this end we are using innovative mouse models, genomic approaches in exome sequencing of patients with these disorders and genome wide expression studies to understand fundamental mechanisms, causative genes and developmental programs necessary for GU and nervous systems to work in harmony in normal and disease states.  

John J. Kotyk, BS, MS, PhD, Research Associate Professor, Associate Director; Human Imaging Unit Email, Website Back to top

Institution: Washington University in St. Louis (WU) Expertise: imaging, biomarkersArea of Clinical or Research Interest: My interests include the development, implementation, and validation of new in vivo MRI technologies as target, mechanism, and outcome biomarkers of disease and measures of drug efficacy/intervention. Efforts focus on translation of new preclinical or basic science methodology (image data acquisition & analyses) into clinical protocols, specifically to: (1) assess whether or not therapeutic agents hit &/or modulate the target, i.e., the receptor; (2) explore the mechanism of action of drug candidates; (3) serially monitor disease progression & regression; (4) evaluate

drug candidate therapeutic efficacy; (5) validate/qualify preclinical methods developed using animal models of disease (and toxicology) as imaging biomarkers in humans; and, (6) ultimately develop prognostic biomarkers that are predictive of the future rate of disease progression which can be used to improve healthcare, therapy, drug development, and as inclusion criteria for new clinical investigations.Resources: ICTS Human Imaging Unit

Leslie D. McIntosh, BA, MPH, PhD, Research Assistant Professor, Pathology and ImmunologyEmail, Website Back to top

Institution: Washington University in St. Louis (WU) Area of Clinical or Research Interest: My interests include using technology to translate and disseminate health data; for example, developing on-line and computer aided surveys in order to reduce input errors, decreasing the time to collect survey data, and increasing user accessibility of the survey. By accessibility I mean modifying a survey (e.g. enlarging the font size, offering voice-interactive modes) to make it more user-friendly. Additionally, the lifecycle of surveys - the development, testing, deployment, and analyses of the instruments and data –is of interest in my research endeavors. I would also like to develop better ways to improve the presentation of data to end-users. I am always interested in

learning new techniques to analyze data, such as conjoint analysis and social network analysis.Resources: ICTS CBMI core and informatics

Robert C. McKinstry, MD, PhD, Radiologist-in-Chief, St. Louis Children's Hospital Back to top

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Research Forum-Child Health Team MembersJune 2014

Email, Website

Institution: Washington University in St. Louis (WU) Expertise: Medical imaging, magnetic Resonance Imaging, neuroscience, image analysis, neororadiologyArea of Clinical or Research Interest: Imaging the developing brain and its response to injury: Magnetic resonance imaging (MRI) allows for noninvasive evaluation of brain development. Most studies performed to date have been descriptive in nature and focused on clinical image interpretation. Recent advances in the speed of image acquisition and image contrast have presented an opportunity to re-evaluate human brain development using controlled, quantitative methods. Dr. McKinstry combines his clinical

interest in pediatric neuroradiology with his expertise in MRI for four ongoing studies at St. Louis Children’s Hospital and in the Biomedical MR Laboratory at Mallinckrodt Institute’s East Building research facility. “Pediatric Study Center for MRI Study of Normal Brain Development” is a multicenter effort to establish a quantitative brain development database, “Evaluation of neonatal brain injury via water diffusion,” seeks to improve our understanding of the mechanism underlying and the timing of newborn brain injury, the ”Silent Infarct Transfusion Trial,” is a multicenter study which seeks to limit brain damage in children with sickle cell disease and “Prefrontally-mediated memory in phenylketonuria,” is a multicenter effort investigating the cognitive abilities of children with PKU. Future efforts will combine anatomical MR methods, DTI, and functional MRI to improve the understanding of the relationship between structural and functional brain development. Furthermore, Dr. McKinstry hopes to investigate neuroprotection schemes that may help limit the sequelae of newborn brain injury. Members of this laboratory develop MRI protocols and use image-processing software to test hypotheses regarding brain development and brain injury. The lab’s research team shares interests in medical imaging and neuroscience.Resources: ICTS Human Imaging Unit

Kelle H. Moley, MD, James P. Crane Professor and Vice Chair of Obstetrics and Gynecology Professor, Vice Chair of Basic Science Research, Director, Basic Research DivisionEmail, Website Back to top

Institution: Washington University in St. Louis (WU)Expertise: Reproduction, development, biorepository, cell biologyArea of Clinical or Research Interest: Dr. Moley is a Reproductive Endocrinologist and Professor of Obstetrics and Gynecology. She is currently Vice Chair and Director of the Division of Basic Science in Women’s Reproductive Science Research. She is also the Co-Director of the Washington University Institute for Clinical and Translational Science. She is PI and Director of the Reproductive Scientist Development Program, a national K12 training program now in its 26th year. She is Program Director of the Women’s Reproductive Health Research Center and PI of a T32 in Reproductive Sciences at

Washington University School of Medicine. Dr. Moley also co-founded the Women and Infant’s Health Specimen Consortium (WIHSC) at Washington University in St. Louis, the largest longitudinal, pregnancy tissue biorepository in North America. Dr. Moley’s research has impacted our understanding of reproductive performance and glucose utilization in diabetic and obese animal models and how these findings are applicable to the pathophysiology of diabetes in humans. Recently her work has focused on developmental origins of adult disease, specifically the susceptibility of offspring to adult diseases such as metabolic syndrome and cancer.

Resources: WIHSC repository

Margaret A. Olsen, BS, MPH, PhD, Research Associate Professor of Medicine and Surgery

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Research Forum-Child Health Team MembersJune 2014

Email, Website Back to top

Institution: Washington University in St. Louis (WU) Expertise: Epidemiology, infectious diseases, administrative data, observational dataArea of Clinical or Research Interest: My primary area of research concerns the epidemiology of healthcare associated infections, including the incidence of infection after a variety of different surgeries, risk factors and outcomes of infection. I am also interested in developing computerized methods of surveillance for surgical site infections and other healthcare associated infections, using administrative and electronic data. I am using large administrative databases to perform surveillance for healthcare associated

infections and for comparative effectiveness research. I am very interested in the use of these large generalizable datasets to compare outcomes after medical and surgical treatments, including the role of facility-level characteristics.Resources: CADR core

Ken B. Schechtman, BS, MS, PhD, Associate Professor of Biostatistics, Research Associate Professor of Medicine Email, Website Back to top

Institution: Washington University in St. Louis (WU) Expertise: clinical trials design, statistical analysis of data, multicenter clinical trials, epidemiologic methodsArea of Clinical or Research Interest: My primary areas of interest involve clinical trials research methodology, the conduct of clinical trials, and the statistical evaluation of clinical trials data. Major areas of application include cardiology, obesity in children and adults, exercise physiology, and asthma. My central concerns in these clinical and translational research projects include developing and implementing study designs that minimize bias and enhance the likelihood that the planned study will confidently address the research

questions of interest and ensuring that research projects are conducted using procedures that further the goals of the study. Additional areas of interest include the design and conduct of epidemiological research.Resources: Research Design & Biostatistics Group (RDBG)

Shalini Shenoy, MD, Teresa J. Vietti MD Scholar in Pediatrics, Professor of Pediatrics, Medical Director, Pediatric Stem Cell Transplant ProgramEmail, Website Back to top

Institution: Washington University School of Medicine, St. Louis Children’s HospitalExpertise: patient oriented research, hematology and oncology, bone marrow transplantArea of Clinical or Research Interest:   My academic focus is on the development of safer less toxic methods of hematopoietic stem cell transplantation in children. Toward this, I am investigating reduced intensity transplantation for children with hemoglobinopathy (sickle cell disease and thalassemia) using the best available related or alternate donors.  

Mark A. Watson, BA, MD, PhD, Associate Professor, Pathology and Immunology Back to top

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Research Forum-Child Health Team MembersJune 2014

Email, Website

Institution: Washington University in St. Louis (WU) Expertise: Genomics, Cancer, BiomarkersArea of Clinical or Research Interest: Application of whole genomic technologies (e.g. DNA microarrays) and biomedical informatics approaches to the molecular characterization of breast cancer and other malignancies. Development and validation of genome-based biomarkers for the prognosis and targeted therapeutic management of cancer.Resources: ICTS Translational Pathology & Biomarker Development resource

Feliciano Yu, BS, MD, MS, Chief Medical Information Officer, St. Louis Children's HospitalEmail, Website Back to top

Institution: Washington University in St. Louis (WU) Expertise: Health informatics, health services research, healthcare information technologyArea of Clinical or Research Interest: Dr. Feliciano “Pele” Yu, Jr., is a general pediatrician with a background in health informatics and health services research. He is also Associate Professor at the Department of Pediatrics, Division of Hospitalist Medicine. Dr. Yu’s primary focus lies in the intersection of health informatics, outcomes research and quality of care. Dr. Yu actively contributes to healthcare quality and informatics activities locally and at the national level. The common theme across Dr. Yu’s work relates to

helping clinicians make better decisions, provide quality care, and improve care delivery processes through the use of health information and communications technology.Resources/Interactions: Center for Biomedical Informatics (CBMI)

Neil H. White, MD, CDE, Professor of Pediatric and Medicine, Director, Pediatric Clinic Research UnitEmail, Website Back to top

Institution: Washington University in St. Louis (WU) Expertise: pediatrics diabetes, endocrinology, hypoglycemiaArea of Clinical or Research Interest: As the Director of the Pediatric Clinical Research Unit (PCRU) for Washington University in St. Louis I am involved in numerous childhood disease processes. My primary discipline is endocrinology, is involved on both the national and international level for the research and treatment of diabetes. I am involved in multiple facets of diabetes from prevention to treatment of the disease. My expertise also includes Wolfram Syndrome a rare genetic variation of diabetes. I am also supported by the Clinical and Translational Science Award grant, and various

grants from pharmaceutical companies. I am also a principal investigator for institutionally-based fellowship training (T32) and career-development (K12) grants from NIDDK.Resources: Pediatric Clinical Research Unit

Yi Zhang, JD, RN, Assistant Dean Clinical Trials Back to top

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Research Forum-Child Health Team MembersJune 2014

Email, WebsiteInstitution: Washington University in St. Louis (WU)

Expertise: Clinical research management; operational & financial expertise in managing research units and research coordinators; FDA (GCP) and Common Rule related regulatory experience; Contracts/budgets negotiations with industry.Area of Clinical or Research Interest: Interested in understanding and providing the best operational infrastructure to support clinical and translational research. Have experience in how to approach industry for clinical research funding and negotiate contracts/budgets. Knowledgeable in FDA and OHRP regulatory requirements for human subject research.

Resources: ICTS CARS (Clinical Research Units), Contracts, Regulatory, Study Coordinator and Recruitment oversight

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Research Forum-Child Health Team MembersJune 2014

Backup/Ad Hoc Team Members:

Dennis J. Dietzen, PhD, DABCC Associate Professor of Pediatrics and Pathology & ImmunologyMedical Director, Core Laboratory; St. Louis Children’s HospitalEmail, Website Back to top

Institution: Washington University in St. LouisExpertise: Clinical Chemistry, Analytical Chemistry, Immunoassay, Mass Spectrometry, Mitochondrial Function, Inborn Errors of Metabolism.Area of Clinical or Research Interest: Dr. Dietzen is certified by the American Board of Clinical Chemistry and directs the Core Laboratory at St. Louis Children’s Hospital. Dr. Dietzen’s interests focus on discovery, translation, and implementation of novel biomarkers in clinical practice. Current discovery and translational efforts are focused on metabolomic

and proteomic definition of liver failure, hypoglycemia, pre-eclampsia, bone disease, and mitochondrial disease. These studies lean heavily on the use of modern liquid chromatography-tandem mass spectrometry. Implementation efforts include clinical trials for new in vitro diagnostic devices and defining reference intervals for a broad range of biomarkers in children from infancy through adolescence.

Allan Doctor, MD, Associate Professor of Biochemistry & Molecular Biophysics, Associate Professor of Pediatrics, Dept. of PediatricsEmail, Website Back to top

Institution: Washington University in St. Louis (WU)Expertise: critical care medicine, biochemistry & molecular biophysics, pathobiologyArea of Clinical or Research Interest:  My research program is focused upon the novel role of RBC based signaling in matching regional blood flow to metabolic need. The RBC transport portfolio is newly appreciated to include 3 gases (O2, CO2, NO), and RBCs appear to serve as vascular control elements by exerting O2 - responsive control over the bioavailability of vasoactive effectors in plasma. My lab explores the biochemical and molecular events critical to this process. This work extends to translational studies of RBC dysfunction in human critical illness, transfusion medicine and blood substitute design.

Resources: Critical Care Medicine

Bradley Evanoff, MD, MPH, Dr. Richard A. and Elizabeth Henby Setter Professor of Occupational, Industrial, and Environmental Medicine; Director, Institute of Clinical and Translational Science; and Assistant Dean for Clinical and Translational Research, School of MedicineEmail, Website   Back to top

Institution: Washington University in St. Louis (WU)

Expertise: Assessment of musculoskeletal symptoms and functional status, epidemiology, workplace intervention studies, community based research. Area of Clinical or Research Interest: Dr. Evanoff is Director of the Institute for Clinical and Translational Sciences, which promotes research and research education to improve clinical research and the translation of research findings to health improvement. Dr. Evanoff is a researcher in the area of occupational health and safety whose research has focused on the epidemiology and prevention of work-related injuries and illnesses, and on workplace intervention studies.

Resources: Institute of Clinical and Translational Sciences

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Research Forum-Child Health Team MembersJune 2014

Brian P. Hackett, MD, PhD Professor of PediatricsEmail, Website Back to top

Institution: Washington University in St. Louis (WU)Expertise: Newborn MedicineArea of Clinical or Research Interest:  I am interested in diseases of the newborn, in particular respiratory diseases of the newborn. My background is in clinical neonatology and I have a long-standing interest in the molecular and cellular regulation of pulmonary development.    

Jane Garbutt, MD, Professor of Medicine and Pediatrics, Medical Director, WU PAARC, Dept. of MedicineEmail, Website Back to top

Institution: Washington University in St. Louis (WU)Expertise: Community Health and EpidemiologyArea of Clinical or Research Interest:   I am interested in community-based research that is relevant to primary care and in collaborating to ensure that beneficial interventions reach those who may benefit from them via dissemination and uptake research, and working for policy change to improve the health of the community. My work is in changing physician and patient behaviors to ensure that the best quality healthcare is delivered and used by those who could benefit.

Resources: Clinical Research Training Center

Mary E. Hartman, MD, Assistant Professor, Dept. of PediatricsEmail, Website   Back to top

Institution: Washington University in St. Louis (WU) Expertise: Epidemiology, health services research, outcomes of critical illness in childhoodArea of Clinical or Research Interest: My primary area of research concerns the epidemiology and outcomes of critical illness in childhood. My area of expertise is in the use of large datasets to examine trends in health services delivery and outcomes. Previous projects have included the use of large administrative datasets to examine variation in care for severe pediatric traumatic brain injury in several large US states, trends in PICU care for pediatric status asthmaticus and the epidemiology of pediatric severe sepsis. Current projects include using health insurance data to examine health

care utilization for children after prolonged PICU admissions and the use of a local ICU dataset to examine the effect of rapid response team implementation.Resources: Critical Care Medicine

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Research Forum-Child Health Team MembersJune 2014

Robert Hayashi, MD, Professor of Pediatrics, Director, Division of Pediatric Hematology/OncologyEmail, Website Back to top

Institution:

Expertise: Hematology, oncology, patient oriented research

Area of Clinical or Research Interest:   Dr. Hayashi's research interest primarily focuses on issues regarding the long term effects of cancer therapy. His efforts examine the nature and spectrum of clinical conditions that effect childhood cancer survivors with the goal of developing interventions that will improve the outlook of this patient population. He is involved in both institutional and national efforts to gain insight in this rapidly evolving area of investigation and he also directs The Late Effects Clinic at St. Louis Children’s Hospital providing comprehensive care for patients afflicted with a broad scope of conditions. Dr.

Hayashi's clinical interests also include bone marrow transplantation, Non-Hodgkin's Lymphoma and post-transplant lymphoproliferative disease (PTLD). He is actively involved in national trials advancing the treatment of patients in these areas.

Marc Haynes, RN, Nurse Manager, Pediatric Clinical Research Unit Email, Website Back to top

Institution: Washington University in St. Louis (WU)Expertise: Pediatric research, Adult research coordination, Adult Emergency Medicine ResearchArea of Clinical or Research Interest: My area of interest is pediatric clinical. As the nurse manager of the Pediatric Clinical Research Unit (PCRU) for Washington University in St. Louis I am very fortunate to be involved with some bedside research projects. The eclectic

research on our unit allows me and my team to be involved in numerous medical disciplines. The PCRU supports NIH, investigator initiated, and industry sponsored research. The main area that I am involved in predominantly is the logistical management of the unit operations and the staff of the PCRU.Resources: Pediatric Clinical Research Unit

Mike Heinz, BS, Assistant Director GTACEmail, Website   Back to top

Institution: Washington University in St. Louis (WU) Expertise: Genomics, Project managementArea of Clinical or Research Interest: Our focus at the Genome Technology Access Center is to provide researchers with access to cutting edge genomic technologies. Our services support research for many Washington University investigators. We offer next-generation sequencing, microarray analyses, and cutting edge PCR. In addition to research, clinical sequencing, microarrays and PCR are done in CAP/CLIA certified laboratories. Services are available at all stages of a project, including experimental design, sample preparation, quality control, pcr/microarray/sequencing procedures, data refining, and advanced analysis.

Resources: GTAC, Genomics and Pathology Services

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Research Forum-Child Health Team MembersJune 2014

Judith Lieu, MD, MSPH, Associate Professor, Associate Residency Program Director, Dept. Of Otolaryngology-Head & Neck SurgeryEmail, Website Back to top

Institution: Washington University in St. Louis (WU)Expertise: clinical epidemiology, pediatric otolaryngology, patient-oriented researchArea of Clinical or Research Interest:   Current research focuses on the effects and consequences of hearing loss in children. I use clinical epidemiology research methods and collaborate with colleagues in neuroscience, psychology, and auditory science to investigate speech-language, cognition, educational effects, executive functioning, and quality-of-life in children with hearing loss.  I have engaged in research in a broad range of otolaryngology topics, including sinusitis, otitis media, tonsillitis, head and neck masses, and evaluation of surgical interventions used in otolaryngology.

J. Philip Miller, BA, Professor of BiostatisticsEmail, Website Back to top

Institution: Washington University in St. Louis (WU) Area of Clinical or Research Interest: Primarily involved in collaborative clinical and translational research projects in a wide diversity of disciplines. Operate coordinating centers for multi-institutional NIH studies, including clinical trials. General biostatistics, study design and research data management.

Mukesh Sharma, PhD, Biomedical Informatics Project Manager

Email, Website Back to top

Institution: Washington University in St. Louis (WU) Expertise: Bioinformatics and molecular biologyArea of Clinical or Research Interest: I studied intracellular lipid-binding protein genes for my Ph.D. thesis in Biology (Molecular and Cell Biology) at Dalhousie University, Halifax, Canada. For my post-doctoral research work at the Washington University School of Medicine, I studied molecular genetic changes associated with formation and progression of pilocytic astrocytoma (WHO grade I, brain tumors). Currently as part of Center for Biomedical Informatics (CBMI), my primary Interest is in conducting collaborative in silico analyses including microarray based gene expression analysis,

mutational analysis, and next-generation sequencing based data analysis (including RNA-seq, ChIP-seq, DNA-seq … etc). Resources: ICTS CBMI core and informatics

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Research Forum-Child Health Team MembersJune 2014

Joshua S. Shimony, MD, PhD, Associate Professor or Neuroradiology, Director of Pediatric NeuroradiologyEmail, Website Back to top

Institution: Washington University in St. Louis (WU) Expertise: MRI, diffusion, perfusion, neuroradiology, neurophysiology, Alzheimer’s disease, pediatric brain developmentArea of Clinical or Research Interest: Dr. Shimony's research focuses on imaging applications in neuroradiology and neurophysiology, primarily using advanced MRI techniques. Recent work has included applications of MR diffusion and perfusion imaging techniques.

Phillip I. Tarr, BA, MD, Melvin E. Carnahan Professor of Pediatrics, Professor of Molecular MicrobiologyEmail, Website   Back to top

Institution: Washington University in St. Louis (WU) Expertise: Microbiome, gut microbes, pre-event resource collectionArea of Clinical or Research Interest: Our work is focused on the intensive study of the host, most particularly the child, and the host's intestinal microbiota in health and disease. We study diverse aspects of this interaction, including specific pathogens (especially diarrheagenic E. coli such as E. coli O157:H7), and human microbial communities, such as in necrotizing enterocolitis, and sepsis.

Brad Warner, MD, Jessie L. Ternberg, MD PhD Distinguished Professor of Pediatric Surgery, Pediatric Surgeon-in-Chief, St. Louis Children’s HospitalEmail, Website Back to top

Institution: Washington University School of Medicine, St. Louis Children’s Hosp.Expertise: extracorporeal membrane oxygenation, surgical nutrition, ulcerative colitis, short bowel syndrome, necrotizing enterocolitis, surgical oncologyArea of Clinical or Research Interest:   Dr. Warner's areas of clinical interest include remedial surgical procedures for short gut syndrome as well as ileal pouch procedures for children with familial polyposis and ulcerative colitis. Our specific research goals include elucidation of the role of epidermal growth factor (EGF) and its intestinal receptor (EGF-R) as a central mediator of the adaptation response.

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Research Forum-Child Health Team MembersJune 2014

David B. Wilson, MD, PhD, Associate Professor of Pediatrics and Developmental Biology

Email, Website   Back to topInstitution: Washington University in St. Louis (WU) Expertise: Hematology, Oncology, EndocrinologyArea of Clinical or Research Interest: My basic research laboratory uses mouse models to study cellular differentiation, organ development, and oncogenesis. My laboratory has published many papers on the topic of GATA transcription factors. My clinical research interest is in the area of bone marrow failure.

Mary Uhlmansiek, Adoption Manger, Clinical Research DataEmail, Website Back to top

Institution: Washington University in St. Louis (WU) Expertise: Clinical Informatics, regulatoryArea of Clinical or Research Interest: My primary interest is to support clinical and translational research projects through the use of informatics tools, including ClinPortal, CIDER, and caTissue. My research background is in the assessment and treatment of PTSD and other sequela of interpersonal violence in both pediatric and adult populations, including data management for several large-scale NIH grants. In addition, I have expertise in research regulations through my previous IRB involvement.

Resources: ICTS CBMI core and informatics

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