Your Autoimmunity ConnectionYour Autoimmunity Connection

The Gateway to Health and Diseasethe oral microbiome, autoimmunity, and personalized nutrition

Your Autoimmunity Connection

Bonnie Feldman, DDS, MBADrBonnie360’s mission is to create a digitally connected world of personalized care for autoimmune patients.

We consult with start-up companies and entrepreneurs who are bringing new products and services that will improve research, diagnosis, and treatment for autoimmunity

The Gateway to Health and Disease

+1.310.666.5312

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Content and Visual Design by Tiffany Simms

Your Autoimmunity Connection

Special Thanks To:

Cindy Crowninshield, Ellen M Martin, and Tiffany Simms

Your Autoimmunity ConnectionYour Autoimmunity Connection

Did You Know?

Microbial DNA can represent 30-60% of

total saliva DNA

Over 700 different species of bacteria

can live in your mouth

Nearly Half of American adults have

periodontitis, (most severe form of periodontal disease)

93% of people with gum disease are at risk for

diabetes

Doi: 10.1177/0022034512457373

Doi: 10.1111/j.1752-7325.2009.00157.x

Doi: 10.1186/s40064-016-3728-6

Doi: 10.1128/JCM.43.11.5721-5732.2005

Your Autoimmunity Connection

What is the Microecology of the Oral Cavity?

Your Autoimmunity Connection Pubmed Health Glossary

Your Autoimmunity Connection

-Omics Research Sets the Stage for a

New View of the Oral Ecosystem

Doi: 10.3402/jom.v7.28223

Your Autoimmunity Connection

Where Do We Find the Microbiome in the

Body?

The Scientist: The Body’s Ecosystem

Your Autoimmunity Connection

What is the Body’s Microbiome

Composed of?

Doi: 10.1038/nrg3182

Your Autoimmunity Connection Doi: 10.1016/j.imlet.2014.08.017

What Characterizes the

Oral Microbiome?

Your Autoimmunity Connection Doi: 10.1111/j.1601-0825.2011.01851.x

The Oral Microbiome’s Impact on

Personalized Health

Your Autoimmunity Connection Doi: 10.5772/63492

What’s the Functional Profile of Saliva Microbiome?

Your Autoimmunity Connection Doi: 10.1038/sj.bdj.2016.865

Can We Identify Which Bacterial

Phyla Characterize the Caries Prone

Person?

Your Autoimmunity Connection Doi: 10.1016/j.imlet.2014.08.017

The Oral Microbiome in

Periodontal Disease

Your Autoimmunity Connection Doi: 10.1016/j.it.2013.09.001Periodontitis

(bone resorption)inflammation

Immunomicrobial Pathogenesis of

Periodontitis

Your Autoimmunity Connection Doi: 10.1016/j.imlet.2014.08.017

Oral Microbiome Changes in

Periodontal Disease

Your Autoimmunity Connection Doi: 10.1038/nri7385

Periodontitis and Systemic Disease

Your Autoimmunity Connection Doi: 10.1111/odi.12589

Autoimmunity & the Oral Microbiome

Your Autoimmunity Connection Doi: 10.1038/nrmicro.2016.83

The Oral Microbiome in

Rheumatoid Arthritis

Your Autoimmunity Connection Doi: 10.1016/j.cell.2015.11.001

Personalized Nutrition

Your Autoimmunity Connection Defining the Spectrum of Personalized Nutriton Solutions

Your Autoimmunity Connection

Company What How For Whom

Predicts blood sugar responses to thousands of different foods based on analysis of individual’s microbiome. Personalize nutrition by rating different foods through app.

Stool samplesBlood testDNA sequence of gut microbiomeAnalysis using patented algorithm

Consumers

Uses certified coaches to develop personalized nutrition plans that help meet your goals while chefs prepare personalized meals delivered to your door.

Home biomarker test kitQuestionairePatent pending engine determines foods/nutrientsCoaching and Chefs

Consumers

Cognitive enhancing compounds that produce minimal side effects.

Manufacture unique combinations of supplements to enhance cognition

Consumers

Discovers natural active ingredients that come from food sources

AI & DNA analysis to access most health-benefitting components in foods (Bioactive Peptides)

Business

Your Autoimmunity Connection

Our Body’s Immune System Starts in the Mouth

Your Autoimmunity Connection

Exploring the Link between the Oral Microbiome and Systemic Disease

Your Autoimmunity Connection

Devine, Deirdre A., Philip D. Marsh, and Josephine Meade. "Modulation of host responses by oral commensal bacteria." Journal of oral microbiology 7 (2015). <http://www.journaloforalmicrobiology.net/index.php/jom/article/view/26941>.

The Overlooked Microbes in Your Mouth What is the Oral Microbiome?

Oral vs Gut Microbiome

Dewhirst, Floyd E., et al. "The human oral microbiome." Journal of bacteriology 192.19 (2010): 5002-5017. <http://jb.asm.org/content/192/19/5002.short>.

Krzyściak, Wirginia, Anna Jurczak, and Jakub Piątkowski. "The Role of Human Oral Microbiome in Dental Biofilm Formation." InTech. N.p., n.d. Web. <http://www.intechopen.com/books/microbial-biofilms-importance-and-applications/the-role-of-human-oral-microbiome-in-dental-biofilm-formation>.

Lloyd-Price, Jason, Galeb Abu-Ali, and Curtis Huttenhower. "The healthy human microbiome." Genome medicine 8.1 (2016): 1. <https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-016-0307-y>.

Nelson-Dooley, Cass. "The Mouth, the Oral Microbiome, and Systemic Inflammation." Institute for Functional Medicine. N.p., n.d. Web. 18 Jan. 2017. <https://www.functionalmedicine.org/home/focus_on/oral_microbiome/>.

What is the Oral Microbiome

Your Autoimmunity Connection

Nelson-Dooley, Cass, and Stephen F. Olmstead. "The Microbiome and Overall Health Part 5: The Oropharyngeal Microbiota's Far-Reaching Role in Immunity, Gut Health, and Cardiovascular Disease." Complementary Prescriptions. N.p., n.d. Web. 19 Jan. 2017. <http://www.cpmedical.net/newsletter/the-microbiome-and-overall-health-part-5-the-oropharyngeal>.

Zarco, Vess, and Ginsburg. “The Oral Microbiome in Health and Disease and the Potential Impact on Personalized Dental Medicine.” Oral Diseases 18.2 (2012): 109–120. <http://onlinelibrary.wiley.com/doi/10.1111/j.1601-0825.2011.01851.x/full>.

The Hidden Gold Mine: Saliva’s ImportanceGlurich, Ingrid et al. “Progress in Oral Personalized Medicine: Contribution of ‘omics.’” Journal of Oral Microbiology 7.0 (2015): 28223. <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561229/>.

Yang, Fang et al. “Characterization of Saliva Microbiota’s Functional Feature Based on Metagenomic Sequencing.” SpringerPlus 5.1 (2016): 2098. PMC. Web. 18 Jan. 2017. <http://link.springer.com/article/10.1186/s40064-016-3728-6>.

Zaura, Egija, et al. "On the ecosystemic network of saliva in healthy young adults." The ISME Journal (2017). <http://www.nature.com/ismej/journal/vaop/ncurrent/full/ismej2016199a.html>.

Your Autoimmunity Connection

Costalonga, Massimo, and Mark C. Herzberg. "The oral microbiome and the immunobiology of periodontal disease and caries." Immunology letters 162.2 (2014): 22-38. <http://www.sciencedirect.com/science/article/pii/S0165247814001874>.

Dewhirst, Floyd E. “The Oral Microbiome: Critical for Understanding Oral Health and Disease.” Journal of the California Dental Association 44.7 (2016): 409–10. <https://www.ncbi.nlm.nih.gov/pubmed/27514152>. Kilian, M., et al. "The oral microbiome–an update for oral healthcare professionals." British Dental Journal 221.10 (2016): 657-666. <http://www.nature.com/bdj/journal/v221/n10/abs/sj.bdj.2016.865.html>. Liu, Bo, et al. "Deep sequencing of the oral microbiome reveals signatures of periodontal disease." PloS one 7.6 (2012): e37919. <http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0037919>.

Our Disease BarometerThe Oral Microbiome in Caries & Periodontal Disease

Chicken or the Egg? The Oral Microbiome & Systemic Disease Nikitakis, N. G., et al. "The autoimmunity–oral microbiome connection." Oral diseases (2016). <http://onlinelibrary.wiley.com/doi/10.1111/odi.12589/full>.

Scher, Jose U., et al. "Periodontal disease and the oral microbiota in new‐onset rheumatoid arthritis." Arthritis & Rheumatism 64.10 (2012): 3083-3094. <http://onlinelibrary.wiley.com/doi/10.1002/art.34539/full>.

Zhang, Xuan et al. “The Oral and Gut Microbiomes Are Perturbed in Rheumatoid Arthritis and Partly Normalized after Treatment.” Nature Medicine 21.8 (2015): 895–905. <http://www.nature.com/nm/journal/v21/n8/abs/nm.3914.html>.

Your Autoimmunity Connection

Biesalski, Hans K. “Nutrition Meets the Microbiome: Micronutrients and the Microbiota.” Annals of the New York Academy of Sciences 1372.1 (2016): 53–64. <http://onlinelibrary.wiley.com/doi/10.1111/nyas.13145/full>.

Marshall, Lisa. "The Personalized-Nutrition Boom." Nutrition Business Journal XX.4 (2015): 1-4. PLM Institute. Apr. 2015. Web. 21 Jan. 2017. <http://plminstitute.org/wp-content/uploads/2015/05/NBJ-Personalized-Nutrition_final_April-2015-_Pages-1-4.pdf>.

Shoaie, Saeed et al. “Quantifying Diet-Induced Metabolic Changes of the Human Gut Microbiome.” Cell metabolism 22.2 (2015): 320–331. <http://www.sciencedirect.com/science/article/pii/S1550413115003307>.

vel Szic, Katarzyna Szarc, et al. "From inflammaging to healthy aging by dietary lifestyle choices: is epigenetics the key to personalized nutrition?." Clinical epigenetics 7.1 (2015): 33. <https://clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-015-0068-2>.

Wasielewski, Helen, Joe Alcock, and Athena Aktipis. “Resource Conflict and Cooperation between Human Host and Gut Microbiota: Implications for Nutrition and Health.” Annals of the New York Academy of Sciences 1372.1 (2016): 20–8. <http://onlinelibrary.wiley.com/doi/10.1111/nyas.13118/full>.

Zeevi, David, et al. "Personalized nutrition by prediction of glycemic responses." Cell 163.5 (2015): 1079-1094. <http://www.sciencedirect.com/science/article/pii/S0092867415014816>.

Zmora, Niv, et al. "Taking it personally: personalized utilization of the human microbiome in health and disease." Cell host & microbe 19.1 (2016): 12-20. <http://www.sciencedirect.com/science/article/pii/S1931312815005089>.

Dinnertime! The Personalized Nutrition Boom