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The John Curtin School of Medical ResearchAnnual Review 2004
Health Through Discovery
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Core research areas for The John Curtin School of Medical Research (JCSMR) include genomics, immunity, gene regulation and cell signalling, neuroscience and integrative physiology. This research means the School can make important contributions to the understanding and treatment of infectious diseases, diabetes, cancer, asthma and high blood pressure.
The School is organised into three major research divisions, Molecular Bioscience, Immunology and Genetics, and Neuroscience, which refl ect the diversity of the medical research disciplines covered by our research programmes. Each division is comprised of independent groups and laboratories. There is also a High Blood Pressure Research Unit headed by the School’s Director, and two collaborative initiatives: a Centre for Bioinformation Sciences (with the School of Mathematical Sciences) and the Australian Phenomics Facility.
A primary aim of the School is to train the medical researchers of the future. Most postgraduate students are carrying out research directed towards a PhD degree. JCSMR also shares supervision of Honours students with the ANU Faculties and other institutions.
Introduction
The John Curtin School of Medical Research was opened in 1958 as a result of the vision of Australian Nobel Laureate Howard Florey and war-time Prime Minister John Curtin. Florey’s vision — that of a national medical research institute carrying out superlative medical research in fundamental areas continues to be realised by scientists in The John Curtin School of Medical Research at The Australian National University.
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Introduction to The John Curtin School of Medical Research From the Director . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .3 Research Highlights . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .4 Signifi cant Outcomes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .5 Organisational Structure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .6 Boards & Committees . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .7
Research Programs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .9 Division of Immunology and Genetics . . . . . . . . . . . . . . . . . . . . . . . .10 Division of Molecular Bioscience . . . . . . . . . . . . . . . . . . . . . . . . . . . 16 Division of Neuroscience . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23 High Blood Pressure Research Unit . . . . . . . . . . . . . . . . . . . . . . . . . 28 Centre for Bioinformation Science . . . . . . . . . . . . . . . . . . . . . . . . . 29
Staff & Student Achievements . . . . . . . . . . . . . . . . . . . . . . . . . . .31
Research Collaborations & Visitors . . . . . . . . . . . . . . . . . . . . . . . . . . 35 Research Collaborations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 36 Visitors to JCSMR . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 43
Staff, Students & Invited Presentations . . . . . . . . . . . . . . . . . . . . . 45 Division of Immunology and Genetics . . . . . . . . . . . . . . . . . . . . . . . 46 Division of Molecular Bioscience . . . . . . . . . . . . . . . . . . . . . . . . . . . 52 Division of Neuroscience . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 56 High Blood Pressure Research Unit . . . . . . . . . . . . . . . . . . . . . . . . . 59 Centre for Bioinformation Science . . . . . . . . . . . . . . . . . . . . . . . . . 60 Students . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 62 School Adminstration & Services . . . . . . . . . . . . . . . . . . . . . . . . . . . 64
Publications . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 67
Contact with our Community . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 77 Voluntary Service to Outside Organisations . . . . . . . . . . . . . . . . . . 80
Support to the School . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 83 Grants . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 84 Statistics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 89 Donors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 90
Table of Contents
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JCSMR 2004
I have great pleasure in presenting The John Curtin School of Medical Research
Annual Review for 2004. The Review provides a summary of the progress and
achievements made by our staff and students throughout the year. It also
includes information about the School, including prizes, degrees awarded and
collaborations with colleagues both nationally and internationally.
The new John Curtin School of Medical Research building has entered the
construction stage. The year began with a wake for the School workshop, with
80 past staff members joining 400 staff, students and friends to celebrate its
technical achievements which have contributed so much to JCSMR discovery.
The workshop was then demolished and a lot of very large holes dug. Over the
year, we watched fl oors laid and walls built.
(See the webcam at http://jcsmr.anu.edu.au/webcam.htm).
Research has continued throughout the upheaval: see Research Highlights and
Outcomes 2004 (pages 4 and 5).
The year concluded with another celebration — for Professor Frank Fenner’s
90th birthday in December. Congratulations Frank.
Judith A Whitworth AC
From the Director
Our strategic goals are to
• Play a leadership role in medical research in Australia
• Conduct research of the highest international standard into fundamental life processes and the pathologies of these processes which cause human disease
• Apply new knowledge for the benefi t of population health, health care and health industries in Australia
• Provide outstanding training in medical research for young scientists and health professionals
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Research Highlights
Research Highlights and Outcomes 2004
• advances in our understanding of how histone proteins and their variants determine nuclear structure, and the fi rst demonstration in mammalian cells that histone proteins have to be removed from the control regions of highly active genes to allow gene expression
• the production of new embryonic stem cells allowing gene knockout experiments to be performed in a wider variety of mouse strains
• the demonstration that nuclear shuttling of some cancer-causing proteins is disrupted in cancer cells
• the design of compounds with potential to treat skeletal and cardiac muscle disorders
• understanding of the molecular events in asthma
• the discovery that spatial segregation of calcium signals inside brain cells plays a powerful role in controlling the strengthening of connections thought to underlie learning and memory in the brain
• the discovery that the properties of auditory neurons in the brains of congenitally deaf mice can be strikingly different to those of hearing mice: appropriate auditory nerve activity during development is important in determining the way auditory signals are processed in the brain
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JCSMR 2004
Signifi cant Outcomes
• the anti angiogenesis drug PI-88 developed in the JCSMR by Professor Chris Parish and colleagues has achieved Orphan Drug status from the US Food and Drug Administration. PI-88 is currently in Phase II human trials as a cancer therapeutic
• HIV/AIDS vaccine technology, developed within the School by Professor Ian Ramshaw and his team, underwent human testing
• the 2003 WHO-ISH Hypertension Statement published by Professor Judith Whitworth and colleagues was the highest web-accessed article in The Journal of Hypertension in 2004
• the Australian Phenomics Facility Building was completed in 2004 and is operational
• students in the JCSMR continue to achieve recognition through the award of numerous travel prizes and Scholarships
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JCSMR 2004
Organisational Structure
The AustralianNational University
Neuroscience
Molecular Bioscience
Immunology and Genetics
Rese
arch
Gro
ups,
Uni
ts a
nd L
abor
ator
iesDirector
The John Curtin School ofMedical Research
Technical Services
Microscopy and Cytometry Facility
BiomolecularResource Facility
Animal Services
Information Technologyand Communications Unit
Serv
ices
and
Sup
port
Student Convenor
Adm
inis
trat
ion
Human ResourceManagement
General Services
Financial and ResearchSupport
Director’s Offi ce
AustralianPhenomics Facility
Centre forBioinformation Science
High Blood PressureResearch Unit
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JCSMR 2004
Boards & Committees 2004
Faculty Board 2004
The Director (Chair), ex offi cioProfessor JA Whitworth
The Deputy Director, ex offi cioProfessor SJ Redman
Chair of Faculty, ex offi cioProfessor IA Ramshaw
Head, Division of Molecular Bioscience, ex offi cioProfessor MF Shannon
Head, Division of Immunology and Genetics, ex offi cioProfessor CR Parish
Head, Division of Neuroscience, ex offi cioProfessor CE Hill
Divisional representativesDr G Karupiah (Division of Immunology and Genetics)
Dr C Raymond (Division of Neuroscience)
Dr D Webb (Division of Molecular Bioscience)
The Convenor, Graduate Program in Medical Sciences, ex offi cioDr VL Ross
Graduate student representativeMs A Moore
By invitationDr MJ Nicol, Public Affairs Offi cer
Mr B Webb, Business Manager
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Director, JCSMR (Chair), ex offi cio
Deputy Director, JCSMR, ex offi cio
Deputy Vice-Chancellor (Research), ANU, ex offi cio
Chair, JCSMR Faculty, ex offi cio
Professor Jerry Adams, The Walter and Eliza Hall Institute, VIC
Professor Rob Baxter, Kolling Institute of Medical Research, NSW (NH&MRC Nominee)
Professor Sam Berkovic, Austin & Repatriation Medical Centre, VIC
Professor Ross Coppel, Monash University, VIC
Professor Tony D’Apice, Department of Clinical Immunology, St Vincent’s Hospital, VIC
Professor Anne Kelso, Queensland Institute of Medical Research, QLD
Professor Kiaran Kirk, Faculty of Science, ANU, ACT
Dr George Morstyn, University of Melbourne, VIC
Professor Gottfried Otting, Research School of Chemistry, ANU, ACT
Professor Brandon Wainwright, University of Queensland, QLD
Strategic Advisory Committee
The purpose of the Research Advisory Board of JCSMR is to provide advice to the Director regarding the School’s current and future scientifi c programmes, and to review research programmes currently undertaken within the School.
Director, JCSMR (Chair), ex offi cio
Deputy Director, JCSMR, ex offi cio
Sir David Akers-Jones, Hong Kong
Professor Peter Doherty AC, (Nobel Laureate) University of Melbourne, VIC
Mr Alan Evans, Strategic Consulting Services, ACT
Mr Peter Gordon, Chief Minister’s Department, ACT
Ms Pru Goward, Federal Sex Discrimination Commissioner, ACT
Professor Colin Johnston AO, Senior Principal Research Fellow, Baker Medical Research Institute, VIC
The Hon Dr Barry Jones AO, VIC
Dr Denis W King, Colorectal Surgeon, St George Private Medical Hospital, NSW
Dr Bronwyn Kingwell, Baker Medical Research Institute, VIC (President Elect — Australian Society for Medical Research)
Mr Andrew Podger, Public Service Commissioner, ACT
Dr John Rose, Director — Air New Zealand; Australian United Investment Company; Ian Potter Foundation, VIC
Dr Brigitte Smith, GBS Venture Partners Limited, VIC (until October)
Mr David Vos, Inspector General of Taxation, NSW
Dr Cameron Webber, GP, ACT
Research Advisory Board
The Strategic Advisory Committee of JCSMR convenes to advise the Director on ways of achieving the School’s strategic direction, including administration and management of the School, raising the profi le of JCSMR nationally and internationally, assist with fundraising activities, and advise on commercialization of research.
The School has three major Divisions: Immunology and Genetics, Molecular Bioscience and Neuroscience. The basic research units of the Divisions are the groups and laboratories. Groups from any division can combine to form formal or informal collaborative and multidisciplinary programs to share resources and strengthen research. The Divisions also provide an administrative framework for student supervision, strategic planning and representation on the Faculty Board.
The following section explains some of the work of the three Divisions and contains essays by some of the School’s researchers about their current research interests.
Research Programs
The John Curtin School of Medical Research Annual Review 2004
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Pro
gram
s
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Pro
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s
Groups and Laboratories
£ Cancer and HumanImmunology Group
£ Cancer and VascularBiology Group
£ Diabetes/Transplantation Immunobiology Laboratory
£ Human Genetics Group
£ Immunogenetics Laboratory
£ Immunopathology Group
£ Infection and Immunity Group
£ Molecular Immunology and Immunopathology Group
£ Molecular Virology Group
£ Vaccine Immunology Group
£ Viral Immunology Group
Division of Immunology and Genetics
Head of DivisionProfessor Christopher Parish
The Division of Immunology and Genetics (DIG) is comprised of a number
of research groups and laboratories that pursue fundamental research into
cellular, molecular and genetic processes of relevance to medicine. Common
medical problems investigated by members of the Division include infectious
diseases, cancer, diabetes, autoimmune disease and mental illness, with
a major interest being the immune system. Specifi c research undertaken
by the Division includes investigations of viral replication, analyses of
the immune response to viral infections, development of HIV and cancer
vaccines, molecular and physiological analysis of autoimmunity and its
contribution to the pathogenesis of diseases such as diabetes and multiple
sclerosis, and research on the processes of infl ammation, blood vessel growth
and spread of tumours.
Several of the groups with overlapping interests have formed collaborative
research programs that focus on specifi c areas and generate synergies
that could not be achieved independently. For example, the Integrative
Genetics Program pools the expertise of several groups in order to address
fundamental questions regarding the biological and clinical signifi cance of
genetic diversity. These studies have implications for the understanding of
the genotype/environmental interactions that appear to play a role in many
disorders such as common forms of mental illness that are characterised by
anxiety and depression, Parkinson’s disease and different forms of cancer.
The research carried out within the Division and its associated programs has
been enhanced by the establishment of the Australian Phenomics Facility.
The mutant mice generated in the Facility provide a range of animal models
for the detailed study of the many biological processes under investigation
within the Division.
The pursuit of long-term basic biomedical science goals makes up most
of the Division’s work but this is balanced by attempts to translate
fundamental discoveries into clinical applications. The latter include the
possible application of negatively-charged sugar molecules as novel anti-
infl ammatory or anti-cancer drugs and naked DNA and recombinant
poxviruses as vaccines for prevention of certain infectious diseases or for the
treatment of cancer. n
Professor Bob Blanden
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One of the great issues of our time concerns how our genome — inherited as a set of chromosomes half from our mother and half from our father — specifi es our growth rate, shape, abilities, behaviour, and disease resistance. The members of the Immunogenomics Laboratory are deciphering how the genome specifi es the correct performance of the body’s ‘sixth sense’ — our immune system.
http://jcsmr.anu.edu.au/group_pages/mgc/
immunogen.htm
Deciphering the Genome Code for our Body’s Defences
Immunogenomics Laboratory
The immune system is made up of billions of
cells, each patrolling the body dynamically,
employing an infi nite repertoire of receptors
to sense any chemical entity entering the
body, and neutralizing those chemicals
that are part of infectious microbes. When
it functions correctly, the immune system
is the source of several of the greatest
advances in public health and industry:
immunization against infections and
monoclonal antibodies. Inappropriate
performance of the immune system,
however, is the root of many of the great
health issues in society today. Insuffi cient
immune reactions account for the spread
of malaria, tuberculosis and AIDS through
large parts of the world, and for diffi culty
eradicating tumour cells after surgery or
chemotherapy. Excessive or misdirected
immune reactions are responsible for
leukemias and lymphomas, autoimmune
diseases such as Type 1 diabetes, allergies,
and organ transplant rejection. Progress
in each of these areas faces a universal
roadblock: we currently understand very
little about how good or bad immune
responses are specifi ed in the genome. Our
laboratory is deciphering how the genome
encodes these responses to illuminate the
steps in the process where these disorders
can be prevented or cured — much as the
discovery that insulin controls blood sugar,
almost eight decades ago, led to new
treatments for diabetes.
The DNA sequence of the human genome
is now known. Like words combined into
sentences and paragraphs, the one and
a half billion DNA letters spell out some
thirty-thousand gene ‘words’, which are put
together in different combinations within
cells of the immune system to specify their
behaviour. A single letter change in a gene
word inherited from one of our parents can
be enough to change the meaning of the
cellular equivalent of a sentence. Given the
right environment, the altered code can
precipitate a bad immune response such as
the autoimmune attack that destroys the
body’s insulin producing cells in diabetes.
Using breakthrough technologies we are
discovering many genes which, when altered
by a single spelling change, dramatically
alter the balance between good and
bad immune reactions. In each case, the
laboratory is revealing the action of these
gene variants by placing them into the
context of the behaviour of immune cells
and combinations with other genes – the
immunological equivalent of deciphering
sentences and paragraphs.
Amongst other research projects, we are
illuminating how and why immune cells
grow uncontrollably in children with
leukemia, or attack different organs of the
body in people with defective AIRE genes.
Understanding how specifi c genes are
interconnected with others in an overall
control code for the immune system will, in
turn, reveal points up or downstream in the
code where the root cause of bad immune
responses can be corrected. n
Professor Chris Goodnow Division of Immunology and Genetics
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Rese
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Pro
gram
s Cancer and Molecular Immunology Laboratory
Invasion of Cells
Dr Mark Hulett Division of Immunology and Genetics
The Cancer and Molecular Immunology
Laboratory of the Cancer and Vascular
Biology Group focuses on understanding
the molecular basis of cell invasion,
with particular interest in infl ammation,
tumour metastasis and new blood vessel
growth (angiogenesis). The major barrier
for invading tumour cells, migrating
leukocytes, and growing blood vessels
(endothelial cells) is the basement
membrane (BM) that surrounds the vessels,
and the extracellular matrix (ECM), which
forms a scaffold in tissues to hold cells
together. The BM and ECM are composed
of an interlocking network of proteins and
complex carbohydrates, and for cells to
breach this barrier they deploy a battery
of enzymes that break down these protein
and carbohydrate components. The major
carbohydrate is heparan sulfate (HS), which
acts as the glue to maintain the integrity of
the BM and ECM. The enzyme responsible
for cleaving HS, heparanase, has been shown
to play a key role in the degradation of
the BM and ECM, and its activity strongly
correlates with the metastatic capacity of
tumour cells and the migratory capacity of
leukocytes and endothelial cells. HS in the
ECM also binds a number of angiogenic
growth factors, and the release of these
by heparanase promotes angiogenesis
and tumour growth. Following our recent
cloning of mammalian heparanase, we have
been able to develop the tools to investigate
how heparanase functions at the molecular
level and to directly determine the role of
heparanase in cell invasion, angiogenesis
and infl ammation.
We are currently working towards
(i) identifying the protease(s) responsible for
processing heparanase to its active form,
(ii) further characterising the molecular basis
of heparanase gene transcription, and
(iii) generating gene targeted mice that lack
heparanase in specifi c cells and tissues to
further defi ne its role in cell invasion and
angiogenesis. n
Our laboratory is interested in infl ammation and blood vessel growth and how they relate to the spread of cancer.
http://jcsmr.anu.edu.au/dicb/hulett/
Research Highlights
£ defi ned the heparanase active site usingsite–directed mutagenesis
£ identifi ed the transcription factor Egr1 as a key regulator of inducible heparanase gene expression in primary T lymphocytes
£ dissected the role of Egr1 in de-regulating heparanase gene expression intumour cells
£ identifi ed a novelendo-sulfatase as a promoter of tumour growth and metastasis
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Research Programs
Professor Arno Müllbacher
Viral Immunology Group
How Do We Fight Viral Disease?
Our immune system employs a variety
of strategies to combat pathogens such
as viruses. Among them are cytolytic
lymphocytes, natural killer and killer T cells,
two specialised subgroups of our white
blood cells. These lymphocytes constantly
survey our body for cells that have become
infected by a virus, and destroy them to
prevent the infected cell becoming a factory
for new virus particles. Among the weapons
used by cytolytic lymphocytes to execute
this function are specialised enzymes called
‘granzymes’, which they secrete when they
recognise an infected cell. Granzymes then
enter the virus-infected cell and trigger
tightly controlled programmed pathways
which ultimately result in the cell’s suicide.
However, by specifi cally searching for
virus-infected cells and making contact
with them (in order to kill them), cytolytic
lymphocytes themselves run a high risk of
picking up virus and becoming infected.
Because of their migratory character, they
would therefore be ideal vehicles to spread
virus around the body. One of the research
projects of the Viral Immunology Group
is to investigate if those granzymes, apart
from triggering suicide in infected cells, can
actually protect lymphocytes themselves
from becoming viral factories if they happen
to become infected with virus.
We use ectromelia virus infection of mice,
which causes the disease mousepox and
closely resembles that of human smallpox,
as a model of a viral infection by a natural
pathogen. We use mouse strains that
normally survive infection with mousepox
but die within a few days when defi cient
in the two dominant granzymes A and B.
These mice die with higher virus load in vital
organs such as the liver — a result not seen
in wild-type mice. This is despite the fact
that cytolytic lymphocytes in these mice are
perfectly able to kill virus-infected cells.
Our investigations in this area focus
on the possibilities that granzymes are
either constitutively expressed in cytolytic
lymphocytes, or induced in cells when
they become infected with virus. By either
inhibiting viral replication inside the
lymphocyte, or committing the killer cell
itself to suicide — very similar to what
they would do to any virus-infected cell
encountered during their surveillance
function. Thus, we are exploring whether
granzymes: a) initiate apoptosis (cell suicide)
of the infected cell, or b) induce degradation
of the genome of the virus in a similar
manner as they induce in target cell suicide
triggered by cytolytic lymphocytes, or c) play
a role in external pathways of reduction of
viral replication, such as anti-viral hormone
induction.
Elucidating additional roles these granzymes
play in controlling virus replication and
spread, besides functioning as effector
molecules of killer T and NK cells, is
of great signifi cance in furthering our
understanding of how the vertebrate host
limits viral replication and assures recovery
and survival. Such insights may allow us
to develop therapeutics for manipulation
of granzyme induction, thus possibly
reducing both morbidity/mortality to viral
infections and, in the case of virally induced
immunopathology, granzyme-mediated
tissue damage. n
The aim of the Viral Immunology Laboratory is to study virus/host interactions and to develop strategies for the prevention or treament of viral disease.
http://jcsmr.anu.edu.au/dicb/MIV/viral.htm
Division of Immunology and Genetics
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s Vaccine Immunology Group
Developing a vaccine against HIV/AIDS
Professor Ian Ramshaw Division of Immunology and Genetics
There are now more than twenty years of
research on HIV vaccines, yet the prospect
of achieving an HIV vaccine for developing
countries is still many more years away.
The most promising vaccines are those
that elicit immune cells that specifi cally kill
virus-infected cells, as antibody responses
fail to neutralise HIV, unlike other virus
infections. Such killers may attack cells
early after infection through recognition
of small fragments of the virus that appear
on the surface of infected cells. Although a
vaccine that induces a good neutralisation
antibody response would be highly desirable,
for many reasons this is unlikely to be
found. Currently the most potent form of
vaccination that elicits these killer cells has
been prime-boost immunisation using a
variety of harmless, genetically engineered
vaccine vectors, including our own approach
of DNA prime and recombinant fowlpox
virus boost. We have demonstrated that this
vaccination strategy works extremely well in
small animals and can protect non-human
primates against HIV infection. However,
our fi rst phase I clinical trial funded through
a NIH consortium involving the Australian
National University, University of Melbourne,
University of New South Wales, University
of Newcastle and CSIRO has produced
disappointing results. The trial involved
immunisation of volunteers with a DNA
vaccine encoding HIV genes and boosting
the response with a non-replicating fowlpox
virus vector encoding the same HIV-1 genes.
The volunteers elicited little or no response
against HIV antigens. Thus despite high
levels of immunity elicited in other models,
the human response to the vaccine was
negligible. We will now undertake a further
trial in Thailand using higher doses of the
vaccines. We therefore need to continue to
develop new approaches to HIV vaccination
and to this end we are investigating new
vaccine technologies that can elicit even
higher levels of killer cells effective at
controlling virus infection. These include the
oral delivery of vectors, the development
of scrambled antigen vaccine approaches
and co-expression of immune stimulating
molecules by the vaccine.
In 1980 smallpox was offi cially declared
globally eradicated by the World Health
Organisation (WHO). The recent threat of
bioterrorism has raised concerns that severe
poxvirus infections, such as those due to
variola (smallpox), monkeypox virus or
other virulent agent, will once again pose a
threat to public health. The current smallpox
vaccines, although effective, can have severe
side effects, especially in immune defi cient
individuals. We are therefore investigating
new approaches to make a better smallpox
vaccine that include genetically engineering
the vaccine to ensure complete safety whilst
inducing enhanced immune responses. n
There is a great need to continue to develop new approaches to HIV vaccination. We are investigating new vaccine technologies that will be more effective in the control of virus infection.
http://jcsmr.anu.edu.au/dicb/ramshaw/
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Research Programs
Dr Charmaine Simeonovic
Diabetes/Transplantation Immunobiology Laboratory
Preventing Rejection in Tissue Transplants
Division of Immunology and Genetics
The immune processes involved in transplant
rejection depend on the type of tissue or
organ, and whether the donor and recipient
belong to the same or different species. The
shortage of human donor organs/tissues
for transplantation in the clinic has led
many researchers to consider the use of
animal tissues and organs. The process of
transplantation between different species
is called ‘xenotransplantation’. One major
concern has been the possible transfer of
animal viruses to humans (‘xenozoonosis’).
The size and make-up of organs / tissues
from pigs and humans are similar and this
has led to pigs being chosen as the preferred
donor animal species for transplantation
to humans. Pig tissues, however, normally
produce their own virus called ‘porcine
endogenous retrovirus’ (PERV). This virus
does not damage the pig cells and both the
host and virus live happily together. While
laboratory experiments have shown that
this virus can be transferred to human cells,
there has been no evidence for such transfer
in patients who, for example, have been
treated with pig skin for serious burns.
Various proteins on the surface of tissue
cells help identify a tissue transplant as
‘foreign’ and they act as targets (like a bulls-
eye) for destruction by the body’s immune
cells. With human-to-human transplants
such proteins are encoded by a group of
genes called the major histocompatibility
complex (MHC). Studies by others have
shown that a different marker (a special
sugar) is recognised on the blood vessels
in pig organs. Our studies of pig tissue
Our research is focussed on ways of helping life-saving tissue transplants survive without having to treat patients with strong immunosuppressive drugs that can lead to other serious health dangers. To achieve this, we must fi rst understand how such transplants are normally destroyed or ‘rejected’ by the body’s immune system.
http://jcsmr.anu.edu.au/dmm/TranImm.htm
transplants (lacking donor blood vessels) in
mice have identifi ed yet another important
marker. This new marker (protein) comes
from the porcine endogenous retrovirus and
is found on the surface of most pig cells.
In mice these pig viral proteins appear to
be recognised in a similar way to pig MHC
proteins.
Other studies in our laboratory have
indicated that if human cells were infected
by porcine endogenous retrovirus, such
foreign viral proteins would be recognised
by the immune system and the infected cells
would be eliminated. This may explain why
patients treated with pig tissues have not
shown evidence of infection. If, however,
the normal immune response was weakened
by strong drug therapy, the infected cells
harbouring pig virus would survive and this
situation could cause other health concerns.
We propose that problems associated
with virus transfer following clinical
xenotransplantation could be avoided by
not using strong immunosuppressive drugs
to prevent transplant rejection and/or by
developing a special breed of pigs which
are unable to make endogenous retrovirus.
A major aim of our research is to develop
safe procedures for preventing the rejection
of tissue transplants (such as pancreatic
islets for treating Type 1 diabetes); such
approaches would eliminate the need for
harmful immunosuppressive drugs. n
Research highlights
£ an immune response against Porcine endogenous retrovirus (PERV)-specifi c proteins accelerates the rejection of pig tissue or cell xenografts in mice
£ an immune response to PERV proteins can be more effective than an immune response to pig MHC in inducing xenograft rejection
£ recognition of PERV proteins alone (in the absence of pig MHC) is suffi cient target for the rejection of pig cell xenografts
£ PERV is a source of major xenoantigens recognised during the rejection of pig tissue or cell xenografts
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Head of DivisionProfessor Frances Shannon
Research in the Division of Molecular Bioscience (DMB) is focused
on understanding the basic molecular and biochemical activities
that defi ne normal cell function, many of which can be disrupted in
disease states. We aim to understand molecular events that underpin
cell: cell communication, cell: environment interactions, membrane
protein function, signal transduction within the cell, protein structure,
nuclear structure and function and gene expression. Disregulation of
these processes is apparent in many diseases such as cancer, asthma
and allergy and autoimmunity. These processes also underpin drug and
carcinogen responses. Researchers in the Division have produced many
exciting fi ndings during past year, including
• advances in our understanding of how histone proteins and their variants determine nuclear structure
• the demonstration for the fi rst time in mammalian cells that histone proteins have to be removed from the control regions of highly active genes to allow gene expression
• the production of new embryonic stem cells from different mouse strains allowing gene knockout experiments to be performed in a wider variety of mouse strains
• the demonstration that nuclear shuttling of certain cancer-causing proteins is disrupted in cancer cells
• the design of compounds with potential to treat skeletal and cardiac muscle disorders
The Division has again continued its success in obtaining grant funds
from NHMRC, ARC, NIH and other funding bodies. Publications in many
prestigious international journals have also been a highlight of 2004.
We farewelled the group of Dr Robyn Slattery during the year and wish
her the best with her new position in Monash University, Melbourne. We
look forward to a productive and happy 2005. n
Groups and Laboratories
£ Allergy and Infl ammation Research Group
£ Autoimmunity andGenetics Laboratory
£ Biomolecular Structure Laboratory
£ Chromatin and Transcriptional Regulation Laboratory
£ Computational Proteomics and Therapy Design Group
£ Cytokine Gene Expression Laboratory
£ Cytokine Molecular Biology and Signalling Group
£ Gene Targeting Laboratory
£ Membrane Physiology and Biophysics Laboratory
£ Molecular Genetics Group
£ Muscle Research Group
£ Ubiquitin Laboratory
17
Research Programs
How the Structure of Biomolecules Relates to Disease
Dr Marco Casarotto
Biomolecular Structure Group
Division of Molecular Bioscience
The structure that molecules adopt in the
body plays a crucial role in all biological
processes and is the key to understanding
the origins of many diseases in humans. The
mission of the Biomolecular Structure Group
is to explore the diverse structural properties
of biomolecules. This will aid in our
understanding of the role that the structure
of biomolecules plays in the body and their
relationship to disease.
A number of diverse projects are currently
the focus of our research efforts, many of
which have the potential to yield useful
therapeutic products. These projects include
studies involving (1) the structure, specifi city
and mechanism of enzymes (2) structural
and functional studies of muscle related
proteins (3) the role of ion channels in virus
associated proteins.
Structure and function of enzymes
The mechanism by which enzyme systems
function is central to the development
of effective therapies associated with
these systems. The enzyme dihydrofolate
reductase is the target for an extensive
ranges of diseases such as cancer, malaria,
and bacterial infections while glutathione
S-transferases (GSTs), are involved in
the metabolism of chemical toxins and
mutagens. A detailed understanding of their
specifi city and mechanism is crucial if one is
to be able to predict the reactions that these
enzymes catalyse. Efforts are underway to
structurally characterise DHFRs and GSTs
and investigate the way that these enzymes
recognise a wide range of compounds.
Structure and function of muscle related proteins
For skeletal and heart muscle to function
properly, careful regulation of calcium levels
must occur. In muscle, two proteins, the
dihydropyridine and ryanodine receptors
play key roles in triggering the release
of calcium. We are using high resolution
Nuclear Magnetic Resonance (NMR)
spectroscopy to investigate how these
proteins function by fi rstly determining the
structure of various regions of these proteins
by NMR and then using this structural
information to determine how they interact.
As a result of this work we have designed a
series of peptides and synthetic compounds
that have the ability to regulate calcium
levels in both skeletal and cardiac muscle.
Such peptide therapies may hold the key
to designing new drugs which may be
benefi cial in the treatment of a range of
muscle related diseases such as heart failure,
malignant hypothermia and muscular
dystrophy.
Role of ion channels in virus associated proteins
Many membrane proteins are essential
components for the survival of viruses and
we are targeting several proteins which form
ion channels. The aim is to design ‘blockers’
of the ion channels based on knowledge
of their stucture. In one case, we have
identifi ed a drug which slows the replication
of the AIDs virus. Work is underway to
chemically and structurally optimise the
effectiveness of this drug. This approach
may give rise to a new generation of drugs
to treat diseases such as HIV/AIDS, hepatitis C
and Ross River Fever. n
Our research will help in the development of drugs for the treatment of diseases such as HIV/AIDS, Hepatitis C and Ross River Fever.
http://jcsmr.anu.edu.au/dbmb/casarotto/
The NMR solution structure of a fragment derived from the ryanodine receptor (DP4)
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The Role of Calcium in Muscle Movement
Muscle Research Group
Professor Angela Dulhunty
The Muscle Research Group is dedicated to
understanding the structure and function of
proteins that translate electrical signals from
the brain into movement. The same proteins
also translate electrical signals that originate
in the heart into cardiac contraction.
Both skeletal movement and heart beat
depend on the release of calcium ions from
intracellular stores. This release is facilitated
by a calcium ion channel in the store
membrane known as the ryanodine receptor
and a calcium storage protein that is called
calsequestrin. A third ‘essential’ molecule
that resides in the surface membrane and
detects the commanding electrical signals
(action potentials), is the dihydropyridine
receptor, a protein which also functions as a
surface membrane calcium ion channel.
The chain of events that translates
electrical signals into release of calcium
ions and muscle contraction requires a
complex communication between the
dihydropryidine receptor, ryanodine receptor
and calsequestrin. The importance of this
signalling pathway is underlined by the
fact that mutations in any of the proteins
can produce lethal disorders, while defects
in their expression lead to developmental
failure and death at or before birth.
Potentially lethal disorders associated with
mutations in the proteins include malignant
hyperthermia, central core disease and
polymorphic ventricular tachycardia. In
addition, muscle fatigue can be attributed
to stresses placed on the signalling system.
We are currently investigating the possibility
that expression of a juvenile form of the
ryanodine receptor contributes to the
muscle defect in myotonic dystrophy.
The molecular basis for the signalling
cascade between the dihydropryidine
receptor, ryanodine receptor and
calsequestrin is not fully understood. These
molecular processes must be defi ned in
order for us to understand movement and
heart beat. The underlying mechanisms must
also be understood for the rational design
of drugs to combat fatigue and alleviate
muscular and cardiac disorders. Our current
research includes a study of interactions
between small domains of dihydropyridine
receptor and the ryanodine receptor that
facilitate signal transduction. In particular,
we are examining the way in which
structural changes in these
domains facilitate their ability
to open the ryanodine receptor
ion channel. The structure
studies are performed using
nuclear magnetic resonance
techniques. The functional
studies are done using an
artifi cial lipid bilayer technique
which allows the measurement
of the ion currents fl owing
through the channel. This
unique system reveals the way in which an
individual ion channel molecule opens and
shuts on a time scale of one thousandth of
a second.
Other projects include a study of small
soluble proteins within the cell that
regulate the signalling cascade between
the dihydropyridine receptor, ryanodine
receptor and calsequestrin and thus regulate
contraction in response to environmental
changes both within the cell or externally.
Finally we are searching for the key parts
of the calsequestrin molecule that enable it
to be an effective calcium storage protein
and to contribute information on amounts
of stored calcium to the ryanodine receptor.
A major part of each of these projects is
to try to understand how mutations that
cause muscle or heart disease can disrupt
signalling between the proteins. We hope
that in the future these studies will enable
us to develop very specifi c compounds for
the treatment of skeletal muscle and heart
disorders. n
We hope that studies carried out by the Muscle Research Group will lead to the development of very specifi c compounds for the treatment of skeletal muscle and heart disorders.
http://jcsmr.anu.edu.au/dbmb/bmb/
Division of Molecular Bioscience
19
Research Programs
Allergy and Infl ammation Research Group
Asthma and Allergy
Professor Paul Foster Division of Molecular Bioscience
Asthma and allergic disorders of the skin
and gastrointestinal tract are increasing at
an alarming rate in western countries and
have now reached epidemic proportions.
Asthma is now a major cause of childhood
absenteeism from school and the work
place and is a major health burden on the
community.
The cause of the rise in allergic diseases
remains unknown but has been linked to
• increased hygiene standards
• exposure to certain infectious agents
(viruses) and environmental factors (such
as pollution)
• increased contact with allergens in the
home and exposure to toxic chemicals in
the work place.
Studies indicate that a combination of
environmental factors in association with
genetic background are likely to be the key
factors that predispose to the development
of disease.
One of the key features of asthma
is chronic infl ammation of the lung.
This means that white blood cells
accumulate in an abnormal way
in the airways of asthmatics, and
it is these cells that are thought
to underlie the clinical features of
Different molecules produced in the lungs during asthma episodes can cause wheezing, narrowing of the airways, and production of mucus.
http://jcsmr.anu.edu.au/dbmb/foster/
disease. The accumulation of white blood
cells in the lung directly correlates with the
severity of asthma and asthmatic attacks.
Often episodes of asthma are linked to
viral infections of the lung. Our research is
focussed on understanding how infections
of the airways can trigger, or play a role in
the development of, asthma. We are also
interested in how infl ammatory molecules
that are produced in the lung during asthma
episodes induce different aspects of diseases.
We are investigating which molecules
regulate wheezing and cause narrowing
of the airways and which regulate the
production of mucus in the airways.
Recently, we have identifi ed a number of
molecules that may play critical roles in
asthma, causing the production of mucus,
narrowing of the airways and wheezing — all
of which are predominant features of the
disease and can cause signifi cant breathing
diffi culty. n
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Using Comparative Genomics to Find and Characterise New Human Genes
Computational Proteomics and Therapy Design
Professor Jill Gready Division of Molecular Bioscience
The recent availability of complete genome sequences for ‘model’ vertebrates, such as fi sh and chicken, underpins powerful new approaches to fi nding human genes by ‘comparative genomics’. Although the human genome has been sequenced, not all the genes have been identifi ed due to the diffi culty of fi nding them amongst the predominant non-coding DNA. As the functionally-signifi cant gene sequences in genomes evolve less rapidly than non-coding sequence, cross-species sequence analysis by comparative genomics provides a means to identify conserved sequences. This provides a powerful method to detect genes, and the short scattered motifs in their promoter regions which bind proteins (transcription factors) which ‘turn on’ the gene, i.e. start the process for the DNA to be read and transcribed into RNA, and, then, translated into protein. Also, many genomes of lower vertebrates are less ‘dense’, i.e. contain much less non-coding DNA, making it easier to initially fi nd genes in these genomes, and then by comparative sequence analysis to fi nd their equivalent human gene.
Recently we have used both these comparative genomics principles to fi nd new human genes in two protein families with many known associations in human disease and dysfunction, and to defi ne and characterise transcription-factor (TF) binding sites in the promoter regions of two genes from one of these families.
Firstly, starting with a new zebrafi sh sequence obtained experimentally by our Italian collaborators, and also available in the zebrafi sh genome database, we discovered in the human, mouse and rat databases that it had a very highly conserved mammalian homologue gene which we called SPRN. SPRN encoded a protein, which we called Shadoo (Japanese shadow), with similar overall sequence structure to prion protein (PrP; gene PRNP), the unusual protein which in an altered conformational state is associated with the fatal neurodegenerative prion diseases, such as BSE in cows and CJD in humans. By comparing sequences for SPRN for the whole gene and fl anking regions for mammals (human, mouse, rat) and fi sh (zebrafi sh Danio rerio and pufferfi sh, Fugu rupripes and Tetraodon nigroviridis), a technique called ‘phylogenetic footprinting’, we found that most of the identifi ed TFs were brain-specifi c, confi rming our experimental tissue expression results that mammalian SPRN appears to be expressed only in brain. Continuing with the comparative genomics approach, we sequenced the PRNP gene for PrP in the Tammar wallaby. Exploiting again the greater evolutionary distance between marsupial and eutherian (human etc.) mammals, we used phylogenetic footprinting to characterise the PRNP promoter region, including identifying some
brain-specifi c TFs. This work, and other computer analyses, allowed the development of an integrated model for the evolution of the whole PrP gene family, including the third member Doppel which has been shown to be expressed only in testis and is required for male fertility.
In our second use of comparative genomics, we undertook a systematic whole-genome analysis of the superfamily of C-type lectin domain containing proteins (CTLDcps) in the then only recently available draft genome for Fugu rubripes and found seven new mammalian genes. We are currently characterizing experimentally two of the new genes with the most obvious disease signifi cance. Both are 4th members of protein groups intensively studied for their disease association: a family of extracellular matrix proteins with expression linked to the semi-differentiated state of the cell and, pathologically, highly expressed in tumours; and a family involved in anticoagulation, cell adhesion and infl ammation control. n
From our studies we have developed ideas on how the functions of some genes may have changed during vertebrate evolution, and how their functions might interact or overlap in mammals, including in humans and in disease. We are currently testing these ideas using experimental and computer-based methods.
http://jcsmr.anu.edu.au/dbmb/gready/
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Research Programs
Chromatin and Transcriptional Regulation Laboratory
The Contribution of Chromatin to Cellular Differentiation and Genome Stability
Dr David Tremethick Division of Molecular Bioscience
that each specifi c cell type expresses its
own characteristic set of genes while
repressing the rest. How these distinct
chromosomal domains are established
remains a mystery. Our studies, which
examined early mouse and Xenopus laevis
development, have revealed that a major
change to chromatin that occurs during
differentiation is a sequential alteration
in the protein composition of chromatin
by the replacement of histones with
their variant forms. We discovered that a
variant of histone H2A, known as H2A.Z
(65% identical to H2A), is essential for cell
survival. Moreover, during differentiation, its
expression increases dramatically assembling
distinct compacted domains of chromatin,
referred to as heterochromatin, throughout
the genome. Based on these results, we
propose that during differentiation, there
is an increase in the quality and quantity
of heterochromatin, which is important for
repressing unwanted genes.
As well as preventing gene expression,
heterochromatin has many other functions
including keeping chromosomes stable
so they can faithfully separate following
cell division. Supporting our hypothesis,
depleting H2A.Z in the cell leads to a loss
of heterochromatin integrity resulting
in defects in the way newly replicated
chromosomes separate (see Figure; note that
in the absence of H2A.Z, newly replicated
chromosomes become sticky so that bridges
form between them as they separate and
move into each new daughter cell).
Chromosomes are the fundamental units of life and therefore we need to understand their form and function.
http://jcsmr.anu.edu.au/dbmb/tremethick/
To understand the function of H2A.Z and
heterochromatin, we took a structural
approach whereby we assembled a very
small part of a chromosome, containing
H2A or H2A.Z, in a test tube. We found that
H2A.Z specifi cally altered the surface of the
nucleosome so that nucleosomes interacted
more tightly with each other consequently
assembling highly compacted domains of
chromatin.
Finally, since the loss of chromosome
stability is a major driving force in cancer,
our studies on H2A.Z and heterochromatin
formation will provide a new understanding
into how cancers develop. It may also
enable new strategies, which stabilise the
chromosome, to be explored. n
One of the most amazing engineering
achievements in nature is how over 2 meters
of genetic material (DNA) can be compacted
and squeezed nearly a million times to fi t
into a human cell. The remarkable structure
that achieves this is chromatin. The basic
repeating subunit of chromatin is the
nucleosome (a nucleosome is made up of
proteins called histones of which there are
four types; H2A, H2B, H3 and H4). About 30
million of these building blocks are required
in every human cell to compact our DNA.
Chromatin is all the more astonishing
because while stably compacting the DNA
into an inheritable form, the chromosome, it
is also a dynamic structure enabling access
to specifi c regions of the genome so that
only a relatively small number of genes are
read and used, the rest remaining repressed.
Cellular differentiation, when a single
fertilised cell develops into a multicellular
organism, is a complex process in which
stem cell chromatin undergoes major
sequential restructuring events. This
chromatin-remodelling event, which
ultimately organises the genome into
distinct functional domains unique to
the differentiated cell type, ensures
Abnormal chromosome segregation in the absence of H2A.Z. Shown is a mouse L929 cell in which chromosomes (coloured red) have not moved properly resulting in the formation of a multinucleated cell and bridges between chromosomes. Microtubules are coloured green.
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Cytokines and the Immune System
Cytokine Molecular Biology and Signalling Group
Professor Ian Young Division of Molecular Bioscience
The body’s immune system is both
remarkable and complex and is a
powerful defence against disease-causing
microorganisms. Immune responses often
require the production of white blood cells
which play specifi c roles in host defence.
Key players in determining the type of
defence the immune system mounts and
in the inducible formation of white blood
cells are hormone-like proteins called
cytokines. Our research seeks an improved
understanding of how cytokines signal
to cells to cause them to grow and divide
or to change their properties so as to be
effective in fi ghting infections. Not all
immune responses are protective. In some
cases the immune system may mount an
inappropriate response which can result
in infl ammatory diseases such as asthma
or gastrointestinal allergy. Occasionally
the orderly development of blood cells
may be disrupted resulting in leukemia.
Cytokines are intimately involved in all these
processes in both health and disease. Our
research interests therefore cover both the
normal roles of cytokines, as well as their
involvement in allergic infl ammation and in
leukemia.
One of the approaches we use to study
how cytokines bind to their receptor
proteins on the outside of cells and achieve
their powerful effects is the technique
of X-ray crystallography. This method
gives a picture of the proteins at atomic
resolution and requires the production of
highly ordered protein crystals which are
analyzed by X-ray diffraction. This work is
done in collaboration with colleagues in the
Research School of Chemistry, and involves
work at a synchrotron X-ray facility overseas.
In order to get enough of these proteins,
which are present in tiny amounts in normal
cells, we use recombinant DNA methods to
turn specially tailored insect cells grown
in the laboratory into miniature protein
factories. Like the famous crystallographer
Max Perutz we believe that the ‘riddle of life
is hidden in the structure of proteins’ and
we are using the techniques of structural
biology to study how cytokines function.
Our recent determination of the structure
of an important cytokine receptor (the
beta common receptor) has given us a
novel insight into how it may function, and
allowed us to use sophisticated genetic
techniques to make changes to the receptor
to probe this further. Recombinant DNA
methods are allowing us to study the
possible role of another related cytokine
receptor (the interleukin-3 receptor) in acute
myeloid leukemia, and to try and develop
new approaches to target and destroy the
leukemic stem cells. Although our research is
focused on cytokines and their receptors, it
is closely interfaced with research on mouse
models of asthma and gastrointestinal
allergy to extend the research into a
biological context. This is achieved by
collaboration with our colleagues in the
NHMRC Program ‘Molecular mechanisms in
the regulation of allergy and infl ammation’.
As our understanding of cytokine signalling
develops we aim to try to develop new drugs
which can turn the cytokine receptors on or
off. Drugs switching off the receptors could
be valuable in treating allergy and asthma
and possibly some forms of leukemia, while
drugs switching them on may prove useful
in speeding up immune system recovery
after chemotherapy. n
Cytokines are hormone-like proteins which play a key role in the appropriate functional response of the immune system. Understanding how they work could lead to the development of drugs for the treatment of diseases such as allergy and asthma, and some forms of leukemia.
http://jcsmr.anu.edu.au/dbmb/young/
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Research Programs
Research within the Division of Neuroscience (DNS) is aimed at understanding
the complexity of information processing which occurs between individual
neurons, within neural networks which underlie complex behaviour, and
between neurons and peripheral target tissues such as the gastrointestinal
tract, blood vessels and the iris. Experiments thus focus on connections within
the brain and peripherally within the autonomic nervous system.
Studies conducted on single synapses within the brain are demonstrating that
information is coded in complex ways depending on the rate of information
transfer. At the cellular level, research is determining the mechanisms by
which neurons integrate information received from multiple synapses with
other neurons to produce a single output. At the systems level, members
of the Division are conducting studies on the auditory and visual pathways
and olfactory cortex to determine how different sensory systems process
information to provide cognitive information about the environment. Since
most complex bodily functions require neural control, research is also directed
towards determining the mechanisms underlying the establishment and
maintenance of functional synapses, and the way in which these synapses can
control gastrointestinal motility and vascular function.
An increased understanding of the processes underlying normal physiological
function is an essential basis for determining how systems are perturbed
during disease states. n
Division of Neuroscience
Head of DivisionProfessor Caryl Hill
Groups and Laboratories£ Autonomic Neuroeffector
Transmission Laboratory
£ Blood Vessel Laboratory
£ Brain Modelling Laboratory
£ Cerebral Cortex Laboratory
£ Developmental Neurobiology Laboratory
£ Movement and Memory Laboratory
£ Neuronal Network Laboratory
£ Neuronal Signalling Laboratory
£ Synapse and Hearing Laboratory
£ Visual Neuroscience Laboratory
Professor Bob Blanden
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Contraction or relaxation of muscles around blood vessels can cause changes in blood fl ow which is important in controlling blood pressure.
http://jcsmr.anu.edu.au/dns/hill/
Understanding the Development of High Blood Pressure
The Blood Vessel Laboratory
variability around the body concerning the
incidence and composition of gap junctions
within the endothelium and muscle and
also between the two cell layers of different
arteries. Further differences in the gap
junctions are found during cardiovascular
diseases such as hypertension.
Our physiological studies are designed
to determine the role played by gap
junctions in arterial function and blood
pressure regulation. The endothelial cells
are important since they produce potent
relaxing factors which can assist in
maintaining arteries in a more relaxed state
which would favour increased blood fl ow.
One of these factors, called endothelium
derived hyperpolarizing factor, or EDHF, is
more important in smaller arteries. Since our
research had shown that myoendothelial
gap junctions, which connect the
endothelial cells with the muscle cells, were
also more abundant in smaller arteries,
we hypothesised that they may play an
important role in the activity of EDHF.
Indeed, our data showed a tight correlation
between the incidence of myoendothelial
gap junctions and the magnitude of
EDHF-mediated vasodilation, both in
different arteries and during development.
Furthermore, EDHF responses in these
arteries were abolished by drugs which block
gap junctions. We therefore concluded that
EDHF requires myoendothelial gap junctions
for its transfer from the endothelium to the
smooth muscle where it causes relaxation.
Since hypertension is characterised by
a decrease in the action of endothelial
relaxing factors, our future research is
aimed at determining what happens to
myoendothelial gap junctions under these
conditions.
Changes in the metabolism of bodily
organs must be matched by corresponding
changes in blood supply and gap junctions
in the endothelium have been shown to be
essential to these spreading responses. Since
we have found a reduction in endothelial
gap junctions in arteries from hypertensive
rats, we hypothesised that there would
also be a reduction in the ability of arteries
to exhibit spreading responses. When we
investigated this in the arteries supplying
the gastrointestinal tract of hypertensive
rats, we found that these responses were
indeed attenuated. We also found that this
change was due to the appearance of a
novel response in hypertensive rats which
reduced the ability of the arteries to relax.
Our current experiments are elucidating the
mechanism underlying this response so that
we can determine whether it contributes to
the development of hypertension. n
Research in The Blood Vessel Laboratory
is aimed at determining the relationship
between arterial structure and vascular
function. All blood vessels are composed of
an inner lining of endothelial cells aligned
along the vessel axis and surrounded by one
to several layers of muscle cells, arranged
circumferentially around the vessel.
Contraction or relaxation of the muscle cells
leads to changes in the vessel diameter and
consequently changes in blood fl ow. As the
arteries get closer to the organs which they
supply with blood, they become smaller in
diameter and have fewer layers of muscle
cells. It is these smaller resistance arteries
which are important in the control of blood
pressure.
Our interest is centered on anatomical
structures called gap junctions and their
component proteins, connexins, which form
channels which connect the cytoplasm of
adjacent cells. These channels allow cells to
communicate with their neighbours. Four
different connexins have been found in
blood vessels and their precise combination
in the gap junctions determines the types
of molecules which can pass through them.
We have shown that there is considerable
Professor Caryl Hill Division of Neuroscience
Research Highlights
£ found that the extent of intercellular coupling within the walls of arteries varies with the location of the vessels within the body
£ demonstrated that intercellular coupling plays a critical role in the ability of arteries to increase blood fl ow
£ demonstrated that the extent of intercellular coupling in arteries changes during hypertension
25
Research Programs
The control of gastrointestinal motility lies
in a balance between myogenic, neuronal
and humoral factors. Recently it was shown
that in the gastric antrum that myogenic
activity is initiated not by smooth muscle
cells but by a specialised population
of Interstitial Cells of Cajal, myenteric
interstitial cells, which generate pacemaker
potentials. Our research group made the fi rst
direct recordings of pacemaker potentials
generated by this group of myenteric
interstitial cells. Each pacemaker potential
depolarised the adjacent longitudinal
and circular layers of smooth muscles.
In the circular layer a second population
of Interstitial Cells which lie amongst
the smooth muscle cells, intramuscular
interstitial cells, respond to the attenuated
waves of pacemaker depolarization and
augment them so allowing calcium entry
into the muscle cells and an associated
contraction. Thus intramuscular interstitial
cells respond to voltage changes and
can themselves generate low frequency
pacemaker activity. An important advance
during 2004 has allowed our research group
to formulate an electrical model
which explains the interactions
between these separate groups of
Interstitial Cells. It has also been
shown that enteric excitatory and
inhibitory nerve terminals rather
than directly affecting smooth
muscle excitability selectively innervated
intramuscular Interstitial Cells. The output
from this second population of Interstitial
Cells then modulates the excitability of
nearby smooth muscle cells.
During the last year the research group
has extended these fi ndings by examining
the properties of intramuscular interstitial
cells in other regions of the gastrointestinal
tract. Firstly the properties of intramuscular
interstitial cells in the fundus were analyzed.
Surprisingly it was found that although this
group of cells continued to act as essential
intermediatory cells which allowed the
transfer of information from inhibitory and
excitatory nerve terminals to the fundus
muscle layers, they had quite different
properties to the intramuscular interstitial
cells lying in the nearby antrum. They were
completely insensitive to voltage change
and lacked the ability to generate low
frequency peacemaker activity. This has
provided the fi rst explanation for how the
fundus is mechanically quiescent whereas
the nearby antrum generates rhythmical
activity. Similar fi ndings have been made
about colonic intramuscular interstitial cells.
Furthermore the unique way in which these
cells respond to inhibitory transmitters has
been explained. Intramuscular interstitial
cells generate a spontaneous low level
of activity and this is suppressed by the
formation of a second messenger. n
Autonomic Neuroeffector Transmission Laboratory
Pacemaker Cells in the Gut
Muscles, nerves and hormones work together to control the activity of cells in the gastro- intestinal tract.
http://jcsmr.anu.edu.au/dns/hirst/
Professor David Hirst & Dr Frank Edwards
Pacemaker cells in the gut. Picture shows myenteric Interstitial Cells of Cajal injected with dye.
Division of Neuroscience
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Professor Steve Redman & Dr Clarke Raymond
Movement and Memory Laboratory
Making Memories
Whenever we learn, changes occur in
our brains. These structural and chemical
changes have long been a mystery, but
over the past 15 years some glimmers of
understanding have emerged.
Brain cells (neurones) communicate via
special points of contact called synapses.
Synapses can be made stronger through
repetitive activation of the connected
neurones, in a phenomenon called long-
term potentiation, or LTP. The ‘long-term’
nature of this increase in synaptic strength
can vary from an hour to weeks or even
years. Strengthening a synapse means that
information passes more easily between
neurones and it is therefore believed to be a
mechanism for making memories.
LTP is triggered by a brief rise in calcium
inside the neurone. The calcium can come
from at least four different sources. One
is via a channel that is opened when the
neurotransmitter (glutamate) released at
the activated synapse binds to a specifi c
receptor molecule. These receptors, known
as NMDA receptors, are located on tiny
structures called spines (see diagram).
Another source of calcium is a calcium store
located inside the spine. When the level
of calcium is raised in the spine, it triggers
release of further calcium from this store via
a receptor called the ryanodine receptor. A
third source of calcium is another calcium
store located in the dendrites adjacent to
the spines (see diagram). Calcium is released
from this store via IP3 receptors. Finally, a
fourth source of calcium is via channels
located in the membrane of the neurone
that are opened by voltage changes that
occur when the neurone is active (voltage-
dependent calcium channel, or VDCC).
We have shown that by varying the duration
of synaptic stimulation, LTP of different
durations can be produced. Furthermore,
we found that LTP lasting for different
durations is selectively triggered by calcium
from different sources. Brief stimulation of
synapses results in LTP lasting for about one
hour. This requires calcium entry through
NMDA channels and subsequent release
of calcium from the store in the spine via
ryanodine receptors. Repetitive stimulation
spread over several minutes induces
LTP that lasts for many hours, perhaps
even longer. This potentiation requires
calcium entry at the cell body via voltage-
dependent channels. An intermediate form
of potentiation, decrementing over several
hours, depends solely on calcium release
from the dendritic store via IP3 receptors.
Thus, our research shows that the source
and location of calcium determines the
duration of LTP. Since calcium is involved
in many different functions in the neurone,
this ‘spatial’ encoding mechanism represents
an elegant way of choreographing multiple
tasks. In the future we will determine the
precise sequence of events that cause each
different calcium source to be activated by
repetitive synaptic stimulation. In addition,
we would like to investigate what happens
after the rise in calcium to cause synaptic
strengthening to last for different durations.
This type of research is important for our
basic understanding of how the brain stores
memories, and will help to produce effective
treatment strategies for disorders of
memory, including Alzheimer’s disease and
drug addiction. n
Memories are thought to be formed by strengthening connections in the brain. We have found that the location of calcium signals inside brain cells determines how long such strengthening will last.
http://jcsmr.anu.edu.au/dns/redman/
Division of Neuroscience
27
Research Programs
How Do Brain Cells Communicate?
The Neuronal Signalling Laboratory conducts
basic research into how nerve cells in the
brain process information. This work involves
recording activity from single nerve cells
using both electrical and optical techniques.
During the course of the last year our
research has focused on the following
issues:
The site of action potential generation in neurons
Single nerve cells in the brain receive
literally thousands of inputs from other
nerve cells every second. Understanding
how this massive amount of information
is processed into an output signal – the
nerve impulse or ‘action potential’ – is
essential to an understanding of how the
brain works. In the past year we have been
investigating where in the axon of neurons
(their main output pathway) nerve impulses
are generated. Using a variety of techniques
we have been able to show for the fi rst time
that nerve impulses in cortical pyramidal
neurons (the main cell type in the cortex)
are generated at the distal end of a region of
the axon called the axon initial segment.
A novel inhibitory action of the neurotransmitter acetylcholine
Nerve cells in the brain communicate
with each other via the release of
chemicals called neurotransmitters.
These neurotransmitters act by having
an excitatory or inhibitory action on the
generation of nerve impulses. Traditionally,
the neurotransmitter acetylcholine, which
plays an important role in learning and
memory, is thought to be an excitatory
neurotransmitter in the brain. We have
recently discovered a novel inhibitory
action of acetylcholine in the cortex. This
fi nding increases our understanding of
how acetylcholine infl uences brain activity.
In addition, our results have important
implications for the treatment of Alzheimer’s
disease, which leads to memory loss, and
is currently treated with drugs that act to
enhance the action of acetylcholine.
Cellular mechanisms underlying absence epilepsy
Epilepsy is often described as an ‘electrical
storm’ in the brain, but despite many efforts
the cellular mechanisms that lead to the
generation of epileptic discharges are largely
unknown. We have examined this issue in a
rat model of absence epilepsy and fi nd that
the expression of a protein responsible for
an ion channel called ‘Ih’ is down-regulated
in nerve cells in the cortex of spontaneously
epileptic rats, leading to an increase in their
intrinsic excitability. These results suggest
that down regulation of Ih may underlie
the generation of epileptic discharges,
and is therefore a potentially important
therapeutic target for the treatment of
epilepsy.
Collectively, this research increases our
understanding of how our brains work. In
addition, the hope is that this knowledge
will help in the development of therapies
to treat conditions associated with brain
dysfunction, such as Alzheimer’s disease and
epilepsy. n
Dr Greg Stuart
Neuronal Signalling Laboratory
Understanding how brain cells send and receive messages can help us in the search for treatments for diseases such as Alzheimer’s disease and epilepsy.
http://jcsmr.anu.edu.au/dns/gstuart/
Division of Neuroscience
Highlights
£ identifi ed the site of nerve impulse generation in the axon of neurones
£ characterised a novel inhibitory action of the neurotransmitter acetylcholine in the brain, with implications for the treatment of Alzheimer’s Disease
£ found that a decrease in the expression of a particular ion channel ‘Ih’ may underlie the generation of absence epilepsy in a rat experimental model
28
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28
Rese
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s High Blood Pressure Research UnitHead — Professor Judith Whitworth
Globally, hypertension or high blood pressure
is the leading cause of death, from heart
attack, stroke or other complications. The
High Blood Pressure Research Unit (HBPRU)
undertakes basic and clinical research into
hypertension, in particular the development
of hypertension caused by adrenal steroid
hormones (glucocorticoids).
We have found glucocorticoid-induced
hypertension relates to altered nitric
oxide (NO) production and function, and
to elevated reactive oxygen species (ROS)
which act by mopping up NO.
We are investigating a range of strategies
relevant to the apparent imbalance
between NO and ROS. Our studies suggest
an imbalance of NO (defi ciency) and
ROS (excess) (nitroso-redox imbalance) is
important in the causation of glucocorticoid
hypertension.
Lydia Hu, a Masters student, found that
hypertension due to the synthetic steroid
dexamethasone, widely used in clinical
practice, is also characterised by nitroso-
redox imbalance, but differs in subtle yet
important ways from hypertension caused
by naturally occurring steroids.
Chrismin Tan, an Honours student, set
up techniques for immunohistochemical
staining for a variety of key enzymes
in nitroso-redox imbalance. Examples
of control and stimulated staining for
nitrosotyrosine are shown in Figure 1.
In an ongoing collaboration with Dr George
Mangos and Associate Professor John Kelly
(St George Hospital, Sydney) clinical studies
are examining cortisol-induced hypertension
and in particular blood vessel function.
In other clinical studies, carried out in
collaboration with Dr David Torpy (Royal
Adelaide Hospital) we found an association
of a polymorphism in a steroid binding
protein with chronic fatigue syndrome. Thus
there may be a genetic predisposition to the
debilitating condition of chronic fatigue. n
Steroid Hormones and Blood Pressure
Professor Judith Whitworth
We are investigating the development of high blood pressure caused by the release of hormones from the adrenal gland.
http://jcsmr.anu.edu.au/jcsmr_pages/
director/
Figure 1 Anti-nitrotyrosine immunoperoxidase staining of rat adrenal gland
(A) Nil primary antibody (B) LPS-treated rat (10 mg/kg)
A B
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Research Programs
Dr Gavin Huttley
Our aim is to examine DNA sequences, and to describe sections which are conserved or changed from generation to generation, and between species. A software toolkit is being developed which will help with our statistical modelling of this data.
http://cbis.anu.edu.au/
Centre for Bioinformation ScienceCo-Directors — Professor Simon Easteal and Professor Sue Wilson
and the causative variant will be lost. From
this we infer that the letter at a genome
sequence position that specifi es an essential
biological attribute will be conserved between
species. Species acquire new abilities, however,
by changing their genome sequence. The
conservation of critical sequence constitutes
the principal information exploited in genome
comparisons to date, but clearly positions with
changed letters can also be important.
Being able to statistically model in rich detail
the mutation tendencies of DNA will serve
to improve our capacity to exploit genomic
sequences. For this reason we are developing
a software toolkit for statistical modelling
of comparative genomics data. This toolkit is
being employed to develop statistical models
of sequence change that refl ect the infl uence
of important biological and chemical factors.
Of particular interest is relating specifi c
molecular processes with patterns of change.
For instance, the transformation of encoded
information into biological outcome has as its
initial step transcription of DNA into RNA. This
process is associated with a system dedicated
to repairing any DNA damage encountered
by this transcription machinery. Accurate
modelling of the effect of
this process on the spectrum
of DNA substitutions in well
characterised regions will
enable us to explore uncharted
regions of genomic sequence.
A particular problem
constraining our capacity to
extract reliable information
from genome comparisons is
the accuracy with which these
genomes are aligned against each other. This
is particularly pronounced for non-protein
coding regions. We aim to develop probabilistic
methods for multiple sequence alignments
that include knowledge of evolutionary
relationships amongst sequences. This
framework will facilitate improved alignment
of regions of the genome that do not encode
proteins.
The ultimate goal of our examinations
of genome sequence data is to infer
the functional relationships among the
components encoded by the genome. If
components interact, these interactions will
constrain the way in which they can change.
Statistical models we have developed show
that pairs of residues within a single protein
sequence change in ways that refl ect their
interactions within the protein’s structure.
By improving our statistical description of how
DNA sequences change, we seek to improve
our capacity to identify the key words in the
genome book, how these words relate to
biological function and how variation in their
spelling contributes to risk of disease. n
Statistics of change and mutation in the DNA sequence
Our research, in collaboration with researchers
both local and internationally, is motivated
by the challenge of maximising our ability to
identify not only the regions of the human
genome sequence that are biologically
important, but also the functional relationships
among those regions.
Current analysis of the human genome
sequence suggest that only about 10% of the
genome’s 3 billion nucleotides appear to be
functionally important. Identifying protein
coding and regulatory regions has therefore
proven extremely diffi cult. The most successful
approaches to date involve comparisons
between the genome sequences of different
species.
The reasons why such comparisons work stem
from the interplay of mutation and Darwin’s
fi lter (natural selection). The genome sequence
is transmitted from one generation to the
next imperfectly, with differences between
the DNA sequence of parent and child arising
due to mutation. If a mutation arises that
makes an individual infertile, for example,
then that individual will not contribute their
genome sequence to the next generation
30
To view the complete content of the research essays on the preceding pages, and a full description of current JCSMR research programs see:
http://annualreport.jcs.anu.edu.au/2004/
Staff & Student Achievements Degrees, Prizes & Awards
A major strategic goal of the JCSMR is to provide outstanding
training in medical research for young scientists. Many of our
academic staff supervise post-graduate scholars through their
Honours, Masters and PhD degrees.
JCSMR staff and students continue to be honoured and
acknowledged through Awards and Prizes presented by local,
national and international organisations.
The John Curtin School of Medical Research Annual Review 2004
32
Deg
rees
200
4 Degrees 2004
PhD degrees awarded 2004Franklin AOn the molecular mechanism of somatic hypermutation (SHM) of rearranged immunoglobulin genes
Gousseva NFunctional characterisation and substrate specifi city of deubiquitylating enzyme Usp2
Green DThe structural / functional relationships of peptides derived from the II-III loop of the skeletal muscle dihydropyrine receptor
Gustiananda MBiophysical studies of repeats of marsupial prion protein: Application of low-resolution spectroscopy methods to low complexity peptide sequences
Halliday DCTAnalysis of gene expression during myeloid cell differentiation
Herbert GAn approach to comparative analysis of multiple loci in molecular evolutionary studies: Evaluation using primate sequences
Johnson-Saliba MAn investigation of in vitro-assembled chromatin as a novel vehicle for gene delivery
Jones ALFunctional studies of histidine-rich glycoprotein
Kampa B Dendritic mechanisms controlling spike-timing dependent synaptic plasticity
MacKenzie JThe role of eosinophils in the regulation of CD4+ T helper 2 regulated infl ammation
Miosge LAGenetic dissection of lymphocyte development and homeostasis
Panchanathan VOn the role of B cells and antibodies in ectromelia virus infection
Papathanasiou PENU mutagenesis for the generation of mouse 4 mutants and identifi cation of genes involved in hematolymphoid development
Rui LB cell regulation by BCR signalling
Rummery N Distribution of gap junction proteins in vascular tissue in normal and diseased states
Silva DMechanisms of beta-cell death
Stevens MOvine lung development: The effects of thyroidectomy
Wang YT Lymphocytes in West Nile virus encephalitis: Protection and Immunopathology
Yates ALGenetic analysis of immune regulation
Masters degree awarded 2004Rana PMMarkers of immune responses on human NK cells and T cells
Congratulations to our students who have successfullycompleted their post-graduate study during 2004
Degrees
Drs Melanie Johnson-Saliba, Ben Quah, Vijay Panchanathan and Diego Silva at their graduation ceremony
33
Awards 2004
Abraham MAPAC Scholarship to attend GAUSSIAN Workshop, SydneyStudent Scholarship to attend the Computational Biology Workshop (Computational and Theoretical Biophysics), University of Western Australia, Perth, WA
Alonso HStudent Scholarship to attend the Computational Biology Workshop (Computational and Theoretical Biophysics), University of Western Australia, Perth, WARACI Student Bursary to attend MM04 (Molecular Modelling Workshop), SydneyAPAC Scholarship to attend GAUSSIAN Workshop, Sydney, NSW
Berntson AAustralian Academy of Science Travel Award (Scientifi c Visits to the USA, Canada, and Mexico Program)
Brown KStudent Poster Prize — Lorne Genome ConferenceASMR Student Poster Prize — Health and Medical Research Conference, The Canberra Hospital, Canberra, ACT
De Mestre AASI Travel Award to attend the 12th International Congress of Immunology, Montreal, CanadaAustralasian Society of Immunology Postgraduate International Travel Award New Investigator Award: Australasian Society of Immunology, awarded at the Annual Scientifi c Meeting, Adelaide, SA
Eichner DASI Student Travel Bursary to attend the Australasian Society of Immunology Annual Scientifi c Meeting, Adelaide, SANIH travel grant to attend Keystone Symposium, Vancouver, Canada
Gage PAustralian Society for Biophysics Bob Robertson Award
Gibson FEWMember of the Order of Australia (AM) for service to science
Harrison JASI Travel Award to attend the 12th International Congress of Immunology, Montreal, Canada
Hyun MNIB Travel Award to attend Protein Society Meeting, Boston USA in 2005
Kannappan BAPAC Scholarship to attend GAUSSIAN Workshop, Sydney, NSW
Liston AASI Travel Award to attend the 12th International Congress of Immunology, Montreal, Canada
Prizes and Awards 2004
Professor Judith Whitworth receives the ANU Vice Chancellor’s Award for Community Outreach
Dr Mario Lobigs (left) receives The Finkel Prizefor 2004 from Drs Alanand Elizabeth Finkel
Prizes and Awards presented to JCSMR staff and students during 2004
Prizes and Awards
34
Awar
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004
Lobigs MFinkel Prize for 2004 for his work: ‘Understanding virulence of the mosquito-borne fl aviviruses: emerging and re-emerging pathogens in developed and developing countries’. The Finkel Prize is presented in recognition of medical research in JCSMR leading to improvements in public health in developing countries.
Murase TNovartis Young Investigator Award: Annual Scientifi c Meeting of The Transplantation Society of Australia and New Zealand, Canberra, ACT
Park SRunner Up Prize for Best Poster Presentation by a Graduate Student in Physiology at the AuPS Annual Conference
Peters KNew Investigator Award — best oral presentation Health & Medical Research Conference, The Canberra Hospital, ACT
Rui LCJ Martin Fellowship to work with Dr L Staudt, National Institutes of Health, USA and Professor C Goodnow on the project entitled ‘The Role of the NF-kB Pathway in Primary Mediastinal B Cell Lymphoma’
Staykova MPresident’s Award: International Society for Immunology. For Service to the Journal of Immunology, presented at the 7th International Congress of Neuroimmunology, Venice, Italy
Taylor MNational Institute of Bioscience Travel Award
Wang YCJ Martin Fellowship to work with Professor Donald Harn at Harvard School of Public Health and Dr Guna Karupiah on a project entitled “Effect of innate immune responses in virus control”
Warren HSPfi zer prize: Best Basic Science Poster presentation. Health and Medical Research Conference, The Canberra Hospital, ACT
Whitworth JAACT Australian of the YearMD (Honoris Causa): University of Sydney, NSWThe ANU Vice Chancellor’s Award for Community Outreach
Wood RASI Student Travel Bursary to attend the Australasian Society of Immunology Annual Scientifi c Meeting in Adelaide, SA
Yang MFrank Fenner Medal for most outstanding PhD thesis submitted in the JCSMRduring 2003
Zelensky AYoung Investigator’s Travel Award: PRICPS 2004 (1st Pacifi c Rim International Conference on Protein Science), Yokohama, Japan
Professor Frank Fenner presentsThe Fenner Medal to Dr Ming Yang
Prizes and Awards
Research Collaborations & Visitors to JCSMR
Researchers within the JCSMR enjoy close scientific association
and collaboration with colleagues throughout Australia and the
world. Some of these collaborative research ventures are listed
in the following pages.
In addition, we have the pleasure of welcoming scientists from
local, national and international universities and research
institutes who visit the JCSMR to present seminars or work
on collaborative research projects within our laboratories and
facilities.
The John Curtin School of Medical Research Annual Review 2004
36
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Baker Dr RTUbiquitin-specifi c proteases in cancerAssociate Professor DA Gray Ottawa Regional Cancer Centre, University of Ottawa, Ontario, Canada Zinc fi ngers in deubiquitylating enzymesDr J Mackay School of Molecular and Microbial Biosciences, University of Sydney, NSWProteins that associate with the proteasomeProfessor J Mayer School of Biomedical Sciences, University of Nottingham Medical School, UK
Bekkers Dr JThe role of syntaxin subtypes in synaptic transmissionDr C Morgans Neurological Sciences Institute, Oregon Health and Science University, Portland, OR, USANeurophysiology of a Galanin receptor knockout mouse with an epileptic phenotypeDr A Jacoby, Dr T Iismaa and Professor J Shine Garvan Institute of Medical Research, Sydney, NSWInfl uence of the dendritic tree on the fi ring properties of neuronsProfessor M Häusser Wolfson Institute for Biomedical Research, University College London, UKSynaptic transmission in neuronal cultures from GAD67-GFP transgenic miceDr Y Yanagawa Gunma University, JapanProfessor K Obata RIKEN, Japan
Berntson Dr ALocalization of calcium channels, and calcium handling proteins in the auditory pathwayProfessor REW Fyffe Center for Brain Research, Wright State University, Dayton, OH, USAExpression of Tmc1 in the auditory brainstem of normal and congenitally deaf dn/dn mice Dr A Griffi th and Dr T Makishima National Institute of Deafness and Communication Disorders & National Institute of Health, Bethesda, MD, USAIn vivo auditory nerve activity in normal and congenitally deaf miceDr A Paolini Bionic Ear Institute and La Trobe University, Melbourne, VIC
Bertram Dr EMRole of 4-1BB receptor in T cell co-stimulationProfessor TH Watts Department of Immunology, University of Toronto, Toronto, CanadaRole of STAT-1 in EAEDr DO Willenborg Neurosciences Research Unit,The Canberra Hospital, ACT
T cell signalling through CARMA1Dr J Cannons National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
Bertram Dr EM and Goodnow Professor CIdentifying genes for tolerance and immunityDr L Lanier, Dr A Weiss, Dr J Cyster and Dr S Watson University of California San Francisco, CA, USA
Board Professor PGStructural analysis of glutathione S-transferases Dr M Parker St Vincents Medical Research Institute, Melbourne, VIC Function of the Zeta class GSTs Dr MW Anders Dept of Pharmacology and Physiology, University of Rochester Medical School, MY, USA Metabolism of arsenic by glutathione transferases Dr H V Aposhian Department of Molecular and Cellular Biology, University of Arizona, AZ, USA Parkinson’s disease, pesticides and glutathione transferase polymorphisms Dr D LeCouteur Centre for Education and Research on Ageing, University of Sydney, Concord RG Hospital, NSWDr G Mellick Department of Neurology, University of Queensland, Princess Alexandra Hospital, Brisbane, QLD
Casarotto Dr MGStructural studies into the mechanism of dihydrofolate reductaseProfessor G Roberts Centre for Mechanisms of Human Toxicity, University of Leicester, UKDr J Basran Department of Biochemistry, University of Leicester, UKChitinase and chitin binding proteinsDr C Vorgias Biology Department, Athens University, GreecePeptide activators of the ryanodine receptorProfessor I Toth Pharmacy Department, University of Queensland, QLDEffects of drugs that block Vpu ion channels studied with NMR techniquesProfessor T Watts and Dr Wolfgang Fischer Biomembrane Structure Unit, University of Oxford, UK
37
Collaborations2004
Research Collaborations
Chaudhri Dr G and Karupiah Dr GPathophysiological signifi cance of reverse signalling through membrane TNFDr J Sedgwick Bone and Infl ammation Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USAModulation of the immune response by virus-encoded cytokine homologsDr A Alcami Department of Molecular and Cellular Biology, Centro Nacional De Biotecnologia, Madrid, Spain
Clements Dr JDynamics of forward and reverse transport by the glial glycine transporter, GLYT1bMs KR Aubrey and Dr RJ Vandenberg Department of Pharmacology, University of Sydney, NSW
Cooper Dr P Adjuvant activity of gamma inulinDr N Petrovsky National Health Sciences Centre, The Canberra Hospital, ACT
Cowan Dr ASynaptic dynamics in the somatosensory cortexDr G Fuhrmann, Dr M Tsodyks andProfessor I Segev Hebrew University andWeizmann Institute, Israel
Cowden Dr WBThe role of nitric oxide in infectious and autoimmune diseaseDr K Rockett Institute of Molecular Medicine, Oxford, UKThe role of NO in regulation of EAEDr DO Willenborg Neurosciences Research Unit,The Canberra Hospital, ACTThe activity and mechanism of action of novel glycoprotein processing inhibitor anti-rejection agentsProfessor A Hibberd Hunter Valley Hospital Transplant Unit, Newcastle, NSW
Foster Professor PSThe characterization of allergic networksDr M Rothenberg Division of Pulmonary Medicine, Allergy & Immunology, Childrens Hospital Medical Centre, Cincinnati, OH, USA The role of IL-13 in asthma and infl ammationDr A Mackenzie Cambridge University, UKModels of chronic asthmaProfessor R Kumar University of NSW, Sydney, NSW
Eosinophil degranulationProfessor J Lee Mayo Clinic, Arizona, USARole of mast cell proteases in asthmaProfessor R Stevens Harvard Medical School, MA, USA
Freeman Dr CRole of glycosaminoglycans in the cellular uptake of virusesProfessor T Bergstrom Dept of Clinical Virology, University of Göteborg, SwedenCleavage of heparan sulphate by mammalian heparanaseDr J Turnbull Molecular Cell Biology Laboratory, School of Biosciences, University of Birmingham, Edgbaston, UKRole of heparanase in the pathogenesis of proteinuriaProfessor D Power and Dr V Levidiotis Austin Hospital, Melbourne, VICHeparanase as an anti-tumour targetDr N Pavlakis Royal North Shore Hospital, Sydney, NSWDr J Joyce and Dr D Hanahan Hormone Research Unit, University of California San Francisco, CA, USA
Goodnow Professor CA programme of screening for ENU-mutations affecting lymphocyte response to antigenDr R Cornall and Professor J Bell Oxford University, UKIdentifying genes for immunity and toleranceDr J Cyster, Professor L Lanier andProfessor A Weiss University of California San Francisco, CA, USAMechanisms regulating islet beta cells in diabetesDr N Petrovsky The Canberra Hospital, ACTMutations affecting male fertilityDr M O’Bryan and Professor D DeKretser Monash Institute of Reproduction and Research, Melbourne, VICMutations affecting the mammary glandDr C Ormandy Garvan Institute of Medical Research, Sydney, NSWRole of Ikaros in blood cellsDr Steve Smale University of California Los Angeles, CA, USADr A Perkins Monash University, Melbourne, VICRole of cbl genes in B and T cell toleranceAssociate Professor W Langdon and Dr C Thien University of Western Australia, Perth, WAHearing mutationsDr H Dahl Murdoch Children’s Research Institute, Melbourne, VIC
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Mucin gene functionsDr M McGuckin Mater Medical Research Institute, Brisbane, QLDDr M Cook Phenomix Aust Pty Ltd, Canberra, ACTAnalysis of atopic disorders associated with mutations affecting antigen receptor signallingDr M Cook and Dr K Nelms Phenomix Aust Pty Ltd, Canberra, ACT
Gready Professor JE and Cummins Dr PLApplication of the ONIOM QM/MM method to simulation of enzyme reactions Dr T Vrevren and Dr MJ Frisch GAUSSIAN Inc, New Haven, CT, USA
Gready Professor JE, Hyun Mr YM and Hulett Dr MDProduction and specifi city of CTLD protein domainsDr R Alvarez Consortium for Functional Glycomics, University of Oklahoma, OK, USA
Gready Professor JE, Vassilieva Ms T and Chakka Mr NEvolution of prion protein and its homologues in marsupials and lower vertebratesDr T Simonic Dept of Animal Pathology, University of Milan, Italy
Gready Professor JE and Zelensky Mr ANStructural genomics of an extracellular protein domainProfessor S Yokoyama and Dr A Tanaka RIKEN Genomic Sciences Center, Yokohama, Japan
Hendry Professor ITesting behaviour of Gz knockout mice using pre-pulse inhibitionDr M van den Buuse Mental Health Research Institute, Parkville, VICGz coupling to dopamine D2-like receptors in vivoDr CD Blaha Department of Psychology, Macquarie University, NSWNeuromuscular growth factors: role of TGF-beta and GDNF in motoneurone survival and deathDr I McLennan Department of Anatomy, University of Otago, NZ Increase of IGFBP1 following hypoxia in the piglet andProtein 14-3-3 in the CSF of newborn rats following hypoxia-ischaemiaDr Z Kecskes The Canberra Hospital, Canberra, ACTHypoxia alters GABAA-subunit compositionDr P Dodd University of Queensland, QLD
Hill Professor CEExpression of connexins at myoendothelial gap junctionsDr SL Sandow University of NSW, Sydney, NSW
Hirst Professor DRegional variations in the properties of interstitial cells in the gutProfessor SM Ward and Professor KM Sanders Department of Physiology, University of Nevada, NV, USA
Hoyne Dr GImmunological analysis of Delta3 mutant miceDr S Dunwoodie Victor Chang Cardiac Institute, Sydney, NSWNotch signalling in T cell leukaemia and regulatory T cell functionDr I Screpanti Department of Clinical Sciences, University of Rome, Italy
Hulett Dr MMolecular mechanisms of cell invasion and angiogenesisProfessor CN Chesterman, Professor BH Chong, Associate Professor PJ Hogg and Dr LM Khachigan The University of New South Wales, Sydney, NSWDr RK Andrews and Professor MC Berndt The Baker Medical Research Institute, Melbourne, VICCharacterisation of the interaction of histidine-rich glycoprotein with leukocyte Fc receptorsProfessor M Hogarth and Dr B Wines The Austin Research Institute, Melbourne, VICMigration of eosinophils in infl ammatory diseaseDr S Hogan Cincinnati Children’s Hospital Medical Centre, Cincinnati, OH, USA
Karupiah Dr GMapping of orthopoxvirus CD8 T cell determinantsDr D Tscharke Queensland Institute for Medical Research, CBCRC, Brisbane, QLDDrs J Yewdell and J Bennink National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Maryland, USA
Karupiah Dr G and Chaudhri Dr GPathogenesis of infl uenza pneumonia and fl avivirus encephalitisAssociate Professor N King Department of Physiology, The University of Sydney, NSWDr R Foxwell Division of Health, Design and Science, The University of Canberra, ACT
Research Collaborations
39
Collaborations2004
Presentation of poxvirus antigens by dendritic cell subsetsDr G Belz and Dr W Heath The Walter and Eliza Hall Institute of Medical Research, Melbourne, VICChemokine receptors in infectious diseasesDr W Kuziel Department of Molecular Genetics & Microbiology, Institute for Cellular and Molecular Biology, The University of Texas at Austin, TX, USAProfessor M Mack Klinikum der Universität Regensburg, Innere Medizin II, Abt. für Nephrologie, Regensburg, GermanyModulation of the immune response by poxvirus-encoded cytokine homologsProfessor M Buller Department of Molecular Microbiology and Immunology, St Louis University, St Louis, MO, USA
Lamb Professor THuman dark adaptation and retinoid re-cyclingProfessor EN Pugh Jr Department of Ophthalmology, University of Pennsylvania, PA, USAPhototransduction in conesDr S Kawamura Graduate School of Frontier Bioscience, Osaka University, JapanDr Y Fukada Department of Biophysics and Biochemistry, Graduate School of Science, Tokyo, JapanHuman electroretinogramDr OAR Mahroo Physiological Laboratory, University of Cambridge, UKMolecular mechanisms of vertebrate phototransductionDr RD Hamer and SC Nicholas Smith-Kettlewell Eye Research Institute, San Francisco, CA, USADr D Tranchina Department of Biology, New York University, USADevelopment of a scanning laser ophthalmoscopeDr FN Reinholz and Dr BA Patterson Lions Eye Institute, Perth, WARegeneration of visual pigment in mice lacking retinal G-protein-coupled receptor (RGR)Dr A Wenzel Laboratory for Retinal Cell Biology, University Hospital Zurich, SwitzerlandVisibility and colour of starsDr DC Nicholls Nicholls Communications, Canberra, ACT
Lobigs Dr MMolecular determinants and mechanisms for virulence attenuation of fl aviviruses belonging to the Japanese encephalitis virus serocomplexDr RA Hall Department of Microbiology and Parasitology, The University of Queensland, Brisbane, QLD
Matthaei Dr KIThe role of IL-5 in smooth muscle hyperreactivity of the gutProfessor S Collins Department of Medicine, McMaster University, Hamilton, Ontario, CanadaThe role of IL-5 and eosinophils in allergyDr M Rothenberg Division of Pulmonary Medicine, Allergy & Immunology, Childrens Hospital Medical Centre, Cincinnati, OH, USAThe role of IL-5 in eosinophil precursor differentiationProfessor J Denburg Department of Medicine, McMaster University, Hamilton, Ontario, CanadaThe control of infl ammatory disease in vivoDr S Breit Centre for Immunology, St Vincents Hospital, Sydney, NSWThe role of mast cells in vivoProfessor S Krilis Department of Immunology, Allergy & Infectious Diseases, The St George Hospital, Sydney, NSWMurine fi lariasis infections in cytokine defi cient miceProfessor A Hoerauf Faculty of Medicine, University of Bonn, Bonn, GermanyParasite infection in gene defi cient miceDr L Dent Head, Eosinophil Biology Laboratory, Microbiology and Immunology, School of Molecular and Biomedical Science, Adelaide University, SAThe role of the ryanodine receptor in vivoProfessor P Allen Department of Anaesthesia, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
Müllbacher Professor AOral induced T cell toleranceDr J Chin Elizabeth MacArthur AG Institute, NSW Department of Agriculture, Camden, NSWThe role of granzyme A in fungal infectionDr R Ashman Oral Biology and Pathology, The University of Queensland, Brisbane, QLDThe role p-glycoprotein during acute viral infectionsDr R Johnston Peter MacCallum Cancer Centre, Melbourne, VICThe role of granzymes in viral infectionAssociate Professor M Smyth Peter MacCallum Cancer Centre, Melbourne, VICThe granzymes in early defence against viral infection
Research Collaborations
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4
Dr J Trapani Peter MacCallum Cancer Centre, Melbourne, VICThe mechanisms of cytolytic lymphocytes in the control of viral infectionsDr M Simon Max Planck Institute fur Immunobiologie, Freiburg, GermanyThe role of poxvirus encoded serpins in cytotoxic T cell induced apoptosisDr R Wallich Department of Immunology, University of Heidelberg, Heidelberg, Germany
Parish Professor C Role of histidine-rich glycoprotein in tumour invasion and angiostatin formation Associate Professor P Hogg and Professor C Chesterman School of Pathology, The University of New South Wales, Sydney, NSWRole of platelets in tumour metastasisDr M Berndt Baker Research Institute, Melbourne, VICProfessor C Chesterman and Professor B Chong School of Pathology, The University of New South Wales, Sydney, NSWCarbohydrate-based inhibitors of leukocyte extravasationDr M Hickey Department of Medicine, Monash University, Melbourne, VICInhibition of vascular restenosis by PI-88Dr L Khachigian School of Pathology, The University of New South Wales, Sydney, NSWNovel complement activation pathwaysProfessor M Walport and Dr M Botto Imperial College School of Medicine, London, UKDevelopment of a liposome-based TB vaccineDr W Britton Centenary Institute of Cancer Medicine and Cell Biology, Sydney, NSWInhibition of spontaneous tumour development by PI-88Dr D Hanahan and Dr J Joyce University of California San Francisco, CA, USA
Parish Professor C and Simson Dr LDevelopment of a liposome-based tumor vaccineAssociate Professor P Hogg School of Pathology, The University of New South Wales, Sydney, NSWThermographic detection systems for tumor establishment and growthMs P McCahon and Dr B Eckersley MIDI - Medical Infrared Digital Imaging, Turner, ACT
Immunosurveillance of MCA-induced sarcomas in TH2-immune defi cient miceAssociate Professor M Smyth Peter Macallum Cancer Center, East Melbourne, VIC
Parish Professor C, Freeman Dr C and Hulett Dr M3D structure of mammalian heparanaseDr M Parker St Vincents Hospital, Melbourne, VIC
Ramshaw Professor IARecombinant viruses expressing immune-modulating agentsDr R Jackson CSIRO Division of Wildlife and Ecology, Canberra, ACTEvaluation of HIV prophylactic and therapeutic vaccinesDr S Kent The University of Melbourne, Melbourne, VICDesign of HIV-1 vaccinesDr D Boyle CSIRO Australian Animal Health Laboratory, Geelong, VICEvaluation of new HIV-1 and hepatitis-C vaccinesDr R Ffrench Pediatric Research Laboratories, Sydney Children’s Hospital, Westmead, NSWDevelopment of vaccines against genetically modifi ed virusesProfessor A Ramsay LSU Health Sciences Centre, New Orleans, LA, USADevelopment of a novel TB vaccineDr W Britton Centenary Institute of Cancer Medicine and Cell Biology, Sydney, NSWEvaluation of a nasopharyngeal cancer therapeutic vaccineProfessor D Moss Queensland Institute of Medical Research, Brisbane, QLD
Ranasinghe Dr CEvaluation of HIV prime boost vaccinesDr S Kent The University of Melbourne, Melbourne, VICHIV vaccines and T cell immunityDr S Turner The University of Melbourne, Melbourne, VICMucosal prime boost vaccinesProfessor A Ramsay LSU Health Sciences Centre, New Orleans, LA, USA
Research Collaborations
41
Collaborations 2004
Rao Dr SMicroarray functional analysisProfessor G Denyer The University of Sydney, NSWComputational promoter analysisDr T Werner Genomatix, Munich, GermanyPKC theta studiesDr D Littman Skirball Institute of Biomolecular Medicine, New York University School of Medicine, USAPKC studiesDr JE Souness Aventis Pharma, Bridgewater, NJ, USA
Redman Professor SJProperties of ventral spinal interneuronesAssociate Professor M Goulding Salk Institute, San Diego, USA
Shannon Professor MFControl of GM-CSF gene transcription in T cellsDr A Holloway Discipline of Biochemistry, University of Tasmania, TASStructure function studies of the transcription factor c-RelDr T Parks Cellegy Ltd, San Francisco, CA, USAThe role of c-Rel in CD28 signalling and regulatory networks in T cellsDr S Gerondakis Walter and Eliza Hall Institute of Medical Research, Melbourne, VICProfessor R Schwartz Laboratory of Cellular & Molecular Immunology, NIH, Bethesda, MD, USATranscriptional networks in T cellsDr K Gardener National Cancer Institute, NIH, Bethesda, MD, USA
Simeonovic Dr CJRegulation of pig proislet xenograft destruction and assessment of the potential for xenozoonoses; the role of anti-PERV immunity in cellular xenograft rejectionClinical Associate Professor JD Wilson Department of Endocrinology, The Canberra Hospital, ACTDr P McCullagh Faculty of Veterinary Science, The University of Sydney, NSW
Stricker Associate Professor CQuantal analysis of cell pairs in the subplate during developmentJ Torres and Professor MJ Friedlander Department of Neurobiology, University of Alabama, USA
Stuart Dr GInteraction of action potentials with inhibitory synaptic eventsProfessor M Häusser Wolfson Institute for Biomedical Research, University College London, UK
Thomson Dr SAHIV clinical trialsAustralian HIV Vaccine Consortium, headed by Dr D Cooper National Centre for Epidemiology and Clinical Research, The University of NSW, Sydney, NSWHepatitis C SAVINEDr RA Ffrench Pediatric Research Laboratories, Sydney Children’s Hospital, Westmead, NSWDr P White Prince of Wales Hospital, Randwick, NSWProfessor A Lloyd Department of Infectious Diseases, Prince of Wales Hospital, Randwick, NSWTuberculosis SAVINEProfessor W Britton The Centenary Institute of Cancer Medicine and Cell Biology, Sydney, NSWNasopharyngeal carcinoma SAVINE Professor D Moss and Dr R Khanna Queensland Institute of Medical Research, Brisbane, QLD
Tremethick Dr DJThe role of histone variants in modulating chromatin fi bre dynamicsDr K Luger Department of Biochemistry and Molecular Biology, Colorado State University, CO, USA
Vinuesa Dr CGRoqin mutations in SLE patientsDr S AddlesteinRoyal Prince Alfred Hospital, Sydney, NSW Dr S Riminton Repatriation General Hospital, Concord, NSWDr D Fulcher Westmead Hospital, Westmead, NSWDr S Alexander Children’s Hospital, Westmead, NSWDr P Pavli The Canberra Hospital, ACTIdentifi cation of novel immune regulators through controlled variation of the mouse genomeProfessor JI Bell and Dr RJ Cornall Henry Wellcome Building of Molecular Physiology, University of Oxford, Oxford, UKDr RR Copley Wellcome Trust Centre for Human Genetics, University of Oxford, UKDr ISD Roberts Department of Cellular Pathology, John Radcliffe Hospital, Oxford, UK
Research Collaborations
42
Colla
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tion
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04
Walmsley Professor BStructure-function studies in the auditory systemProfessor REW Fyffe Center for Brain Research, Wright State University, Dayton, OH, USAVoltage-gated channels in auditory neuronsProfessor ID Forsythe University of Leicester, UKNeuronal fi ring properties in congenital deafnessDr A Paolini Bionic Ear Institute and Latrobe University, Melbourne, VIC
Warren Dr HSKIR2DL4 expression and regulation Dr CS Witt and Professor FT Christiansen Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital, Perth, WAAnalysis of NK cells and T cells in cord blood of preterm babiesDr A Kent Department of Neonatology, The Canberra Hospital, Canberra, ACTDr J Dahlstrom Department of Anatomical Pathology, The Canberra Hospital, Canberra, ACT
Whitworth Professor JA, Schyvens Dr C and Zhang Dr YGlucocorticoid receptors in knockout miceDr TJ Cole Department of Biochemistry and Molecular Biology, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, VICMechanism(s) by which glucocorticoids induce hypertension in humansDr J Kelly and Dr G Mangos St George Hospital, Sydney, NSW
Effects of antioxidants and glucocorticoids on plasma F2-isoprostane concentrationsAssociate Professor K Croft School of Medicine and Pharmacology, Royal Perth Hospital Unit, University of Western Australia, WAOptimising microarray in experimental hypertensionProfessor W Anderson Department of Physiology, School of Biomedical Sciences, Monash University, Clayton, VICPlasma BH4 analysisDr J Earl Department of Clinical Biochemistry, The Children’s Hospital at Westmead, NSW
Willenborg Dr DOEvaluation of radiolabelled peripheral benzodiazepine receptor (PBR) ligands in the animal model “experimental autoimmune encephalomyelitis”. Potential probes for the diagnosis of “Multiple Sclerosis”Dr A Katsifi s Australian Nuclear Science & Technology Organisation, Lucas Heights, NSW
Young Professor IGRole of IL-3 receptor in myeloid leukemiaDr K F Bradstock Department of Haematology, Westmead Hospital, Sydney, NSWCrystallization of the modular transporter of anticancer drugs for its subsequent X-ray studiesProfessor AS Sobolev Department of Biophysics, Moscow State University, Russia
Research Collaborations
Dr Sobolev (left) with Professor Young, JCSMR
43
Visitors 2004
Visitors to JCSMR 2004
Alexander Dr W Division of Cancer and Haematology, The Walter and Eliza Hall Institute, Melbourne, VIC
Aumann Dr T Howard Florey Institute, University of Melbourne, VIC
Bagley Dr E Pain Management Research Institute, University of Sydney, NSW
Bellingham Dr M School of Biomedical Sciences, University of Queensland, QLD
Berkovic Professor S Epilepsy Research Centre, Austin Research Institute, West Heidelberg, VIC
Callister Dr R School of Biomedical Sciences, University of Newcastle, NSW
Carrive Dr P School of Medical Sciences, University of NSW, Sydney, NSW
Choo Professor A University of Melbourne, VIC
Clark Professor S The Garvan Institute of Medical Research, Darlinghurst, NSW
Craik Dr D Institute for Molecular Bioscience, The University of Queensland, QLD
Davies Dr P Howard Florey Research Institute, University of Melbourne, VIC
Edwards Dr F Department of Physiology, University College London, UK
Egan Dr G Howard Florey Institute, University of Melbourne, VIC
Gert Professor B Stone Professor of Intellectual and Moral Philosophy, Dartmouth College, NH, USA
Göcke Emeritus Associate Professor RSchool of Dentistry, University of Rostock, Germany
Goulding Dr M The Salk Institute for Biological Studies, San Diego, CA, USA
Grigoryev Assistant Professor S Department of Biochemistry and Molecular Biology, Penn State University School of Medicine, PA, USA
Hall Dr D Department of Chemistry, University of Cambridge, UK
Hallermann Mr S University of Freiburg, Germany
Hume Dr D Institute for Molecular Bioscience, The University of Queensland, QLD
Koenderman Dr L Dept of Pulmonary Diseases, University Medical Centre, Utrecht, The Netherlands
Langdon Professor WY School of Surgery and Pathology, University of Western Australia, WA
Macefi eld Dr V Prince of Wales Medical Research Institute, Randwick, NSW
Mahroo Dr O University of Cambridge, UK
Marley Dr P Department of Pharmacology, University of Melbourne, VIC
Mattick Professor J Institute for Molecular Bioscience, The University of Queensland, QLD
McColl Professor S School of Molecular and Biomedical Science, University of Adelaide, SA
McLachlan Professor E Prince of Wales Medical Research Institute, Randwick, NSW
Colleagues from local, national and international universities and medical research institutes visited the JCSMR during 2004
Professor Elspeth McLachlan, Prince of Wales Medical Research Institute
44
Visi
tors
200
4
Visitors
Morley Associate Professor J School of Medical Sciences, University of NSW, Sydney, NSW
Nicholls Dr DC Nicholls Communications, Canberra, ACT
Page Dr M Head of Biology, Basilea Pharmaceutica Ltd, Basel, Switzerland
Phillips Dr B Department of Physiology, University of Sydney, NSW
Ragan Dr M Institute for Molecular Bioscience, The University of Queensland, QLD
Ramshaw Dr HS Cytokine Receptor Laboratory, Human Immunology, IMVS, SA
Read Dr SHanson Institute/Institute of Medical and Veterinary Science, Adelaide, SA
Reid Dr C Department of Physiology, University of Melbourne, VIC
Roberts Dr B School of Pharmaceutical and Molecular Sciences, University of South Australia, SA
Rostas Professor J School of Biomedical Sciences, University of Newcastle, NSW
Saunders Dr B Mycobacterial Research Laboratory, Centenary Institute, Sydney, NSW
Scott Dr H Genetics and Bioinformatics, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC
Simmons Professor P Peter MacCallum Cancer Centre, Melbourne, VIC
Sobolev Professor ASProfessor of Biophysics, Moscow State University, Moscow, Russia
Stacker Dr S Ludwig Institute for Cancer Research, Melbourne, VIC
Strasser Dr A Molecular Genetics of Cancer Division, The Walter and Eliza Hall Institute, Melbourne, VIC
Stumbles Dr P Faculty of Medicine and Dentistry, University of Western Australia, WA
Taylor Dr R Neurological Sciences Institute, Oregon Health and Science University, Portland, OR, USA
Teramoto Dr N Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Thompson Professor P Centre for Asthma, Allergy and Respiratory Research, University of Western Australia, WA
van Helden Dr D School of Biomedical Sciences, University of Newcastle, NSW
Vaney Professor D School of Biomedical Sciences, University of Queensland, QLD
Vickery Dr R School of Medical Sciences, University of NSW, Sydney, NSW
Vorgias Professor CE Faculty of Biology, National and Kapodistrian University of Athens, Greece
Young Dr H Department of Anatomy & Cell Biology, University of Melbourne, VIC
Dr David Hume, Institute for Molecular Bioscience, The University of Queensland
Staff, Students & Invited Presentations
The following section provides a directory of our staff and
students during 2004, under their Divisional groupings.
Included in this section is a summary of scientific presentations
our staff and students have been invited to make at
universities, conferences and medical research institutes both
nationally and internationally throughout the year.
The John Curtin School of Medical Research Annual Review 2004
46
Pres
enta
tion
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Sta
ff 2
004
Staff 2004
Professor and Head of DivisionParish CR, BAgrSc (Melb), PhD (Melb)
School Technical Support Offi cerWoodhams CE, BAppSc (CCAE), GradDipInfSyst (UC)
Senior Divisional AdministratorWeil ETF
Divisional AdministratorChivas FA
Cancer and Human Immunology GroupFellow and LeaderWarren HS, BSc(Hons), PhD (Qld), NHMRC Senior Research Fellow
Research FellowBettadapura J, MSc, PhD (Bangalore, India)
Research AssistantWaldron J, MSc (Qld) (until August)
Technical Offi cerHilton M, BA, BSc(Hons) (until October)Hewitt K, BSc (from October)
Research ScholarRana PM, BMedTech (Tribhuwan University, Nepal) (until January)
Cancer and Vascular Biology GroupProfessor and LeaderParish CR, BAgrSc (Melb), PhD (Melb)
FellowFreeman C, BSc(Hons) (Adel), PhD (Adel)
Viertel Senior Medical Research FellowHulett M, BSc(Hons) (Melb), PhD (Melb)
Research FellowsHindmarsh EJ, BSc(Hons) (Syd), PhDRao S, BSc(Hons) (Keele Univ, UK), PhD (Kings College, London)
Postdoctoral FellowsQuah B, BSc, PhDSimson L, BSc (UC), PhD
Research AssistantsJones A, BScAgr(Hons) (Syd), PhD (from October)Barlow V, BSc(Hons), LLB (ANU), LLM (UTS), Grad.Dip.Legal Practice (College of Law NSW) (September-November)
Visiting FellowsAda GL, DSc (Syd) FAA, PhDAltin J, BSc, GradDipSci, PhDBurch WM, BSc (Melb), MSc (Melb) PhD (Lond) (from August)
Chesterman C, MBBS (Syd), DPhil (Oxf), FRACP, FRCPAClark IA, BVSc (Qld), PhD (Lond), DSc (Lond)Cooper PD, DSc, PhD (Lond)Johnson-Saliba M, BSc(Hons), MSc (Univ Cape Town), PhD (from March)Mims C, BSc, MD (Lond)Miliotis C, MBBS (NSW) (from May)Sharma S, BSc, MSc, PhD (Delhi University) (from March-September)Staykova M, PhD (The University of Sofi a, Bulgaria)Willenborg DO, BSc (Illinois), MSc (Calif), ScD (Johns Hopkins)
School AssociateBuckley I, MBBS, PhD (Melb)
Senior Technical Offi cersBezos A, BSc (Syd) MSc (Syd)Hornby J, BSc(Hons) (Queens, Belfast)
Technical Offi cersBrowne A, BAPagler E, BS (MedTech Univ Santo Tomas, Philippines)Vavrina-Kun A, BMedSci (from November) (part-time)
Visiting Technical Offi cerGomersall T, BAppSc (UC) (from November)
Laboratory Technician (part-time)Peng J
Editorial/Administrative Assistants (part-time)Francis S (February-April)Gernert A, MA (Ludwig-Maximilians Univ Munich) (from June)Hicks K (until February)
Diabetes/Transplantation Immunobiology LaboratoryFellow and LeaderSimeonovic CJ, BSc(Hons), PhD
Visiting FellowsMcCullagh P, MBBS (Melb), DPhil (Oxon), MRCP (Lond), MD (Melb)Wilson JD, BSc(Hons), MB BCh, BAO(Hons), MD (Queens, Belfast), MRCP (UK), FRACP
Technical Offi cersBrown D, AssDipAppPath (CIT) (part-time)Hamilton P, Certifi cate II in Animal Technology (CIT)Harris K, BAppSc(H Biol) (UC), DipAppScMedLabTech (CIT) (until February)(from July) (part-time)Lynch C-A, Cert Vet Nursing (CIT) (until July)Newington D, BSc (February-June)Popp SK, BSc, AssDipAppSci, Biol (CIT)
Division of Immunology and Genetics (DIG)
47
Staff 2004
Division of Immunology and Genetics
Human Genetics GroupProfessor and LeaderEasteal S, BSc (St Andrews), PhD (Griffi th) (on leave from July)
Senior Technical Offi cerTan X, BSc, (Shandong University, Jinan), MSc (China Pharmaceutical Univ, Nanjing)
Technical Offi cerZhang Y, MSc (Xinjing, China) (until May)
Visiting ScholarMather K, BSc(Hons) (La Trobe), Bsc(Hons) (ANU), GradDipPsy (Charles Sturt)
Immunogenomics LaboratoryProfessor and LeaderGoodnow CC, BVSc(Hons)(Syd), BScVet(Hons) (Syd), PhD (Syd), FAA
Executive Assistant to Professor GoodnowVitler L
Senior Research Fellow and Program Leader
Regulatory Genes in DiabetesHoyne G, BSc(Hons) (UWA), PhD (UWA)
Research Fellow and Program Leader
Genes Controlling Humoral Immune ResponsesVinuesa CG, LMS(MBBS) (Madrid), DRCOG, (Lond) MSc, PhD (Birmingham, UK)
Research Fellow and Program Leader
Genes Controlling T cell ResponsesBertram E, BSc(Hons) (Adel), PhD (Adel)
FellowsHorikawa K, MD (Chiba University), PhD (University of Tokyo)Tze L , BSc (Beloit College, USA), PhD (Minnesota)
Postdoctoral FellowsMiosge L, BSc(Hons), PhD (until October)Rui L, MS (Shanxi Medical University China), BM (Wannan Medical College China), PhD (from January)
Visiting FellowsAthanasopolous V, PhD (Melb) (from March)Cornall R, PhDFahrer A, BSc(Hons) (Melb), PhD (Melb)Yates A, BSc(Hons), PhD (from April)
Laboratory ManagerTownsend M, PathTech Cert (TAFE), AssDipAppPath (Bruce TAFE)
Laboratory Technical Staff
In charge of molecular biologyWhittle B, BSc(Hons)
In charge of geneticsAngelucci C, BSc(Hons) (Deakin), PhD
In charge of fl ow cytometryDawson S, BAppSci (UC)
In charge of pre-immune serologyDomaschenz H, PathTechCert (TAFE)
In charge of immune serologyKucharska E, BSc, MSc (Warsaw)
LentivirologyAthanasopolous V, PhD (Melb) (until March)
Genotyping teamBuckle D, BSc (Melb), MSc (Auck)Ewing S, BiolTechCert (TAFE)Hamilton A, DipPathTest (CIT)Howard D, BScPulsford K, DipAppSci (CIT)
Immune screening teamCurwen P, BAppSci (UC)Dinsdale A, BSc(Hons)
TransplantationJ Zarb (until May)
Lab AssistantsKnight A (February-December)Ross STempleton M (February-August)
Visiting ScholarsJohnson AL, BSc (William Jewell College, Liberty, USA) (from May)Martinez M (July)
Immunopathology GroupFellowsCowden WB, BS (Troy State), PhD (Qld)Charlton B, MBBS, PhD (UNSW) (until December)
Visiting FellowsEschler B, BSc(Hons) (Syd), DipEd (Syd), MSc (Syd), PhD (Wollongong)Francis D, BVSc (Syd), MVSc (Syd), PhD (Syd)Jenkins N, BSc(Hons) (Adel), PhD (Adel)March D, BSc(Hons) (Adel), PhD (Qld)Silva D, MBBS (Univ of Colombia) (from March)
Technical Offi cersBartell G, BSc(Hons) (Syd), MScGapella JP, Animal Tech Cert (TAFE)
48
Staf
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04
Division of Immunology and Genetics
Laboratory TechniciansHiggins D, DipApplSci (CIT)Lejsek E, BSc, Grad Dip (CSU)
Visiting ScholarArnett S (July-December)
Infection and Immunity GroupSenior Research Fellow and LeaderKarupiah G, BSc(Hons), MSc (Univ. of Malaya), PhDInternational Research Scholar of the Howard Hughes Medical Institute
Research FellowChaudhri G, BSc(Hons), PhD
Postdoctoral FellowsPanchanathan V, MBBS, MPhil (University of Malaya) (from July)Wang Y, MB (Beijing Medical University), MM (Syd) (June-November)
Visiting FellowsBelz G, BVBiol (Qld), BVSc(Hons) (Qld), PhD (Qld)Foxwell R, BSc (WA), Bsc(Hons) (Melb), MSc (Lond), PhD (UC), GradCert Higher Education (UC)Scalzo A, BSc(Hons) (Melb) PhD (Melb)
Senior Technical Offi cersDeChazal R, Assoc Dip Animal Science (CIT) (from August)Tha Hla R, BRTC (TAFE) (from September)Zhou J, BMed, (Beijing Medical University), MMed (Syd)
Technical Offi cersChurch A, BSc(Hons) (until February)DeChazal, R Assoc Dip Animal Science (CIT) (until July)
Laboratory TechnicianPeng J (part-time)
Visiting ScholarMendoza N (June-August)
Vaccine Immunology GroupProfessor and LeaderRamshaw IA, MSc (Brunel), PhD
Research FellowsRanasinghe C, BSc (Univ Rouen, France), MPhil (Univ Colombo), PhD (UWA) (from August)Thomson S, BSc (Syd), PhD (Qld)
Postdoctoral FellowsBanyer J, BSc(Hons) (Griffi th), PhD (until February)Ranasinghe C, BSc (Univ Rouen, France), MPhil (Univ Colombo), PhD (UWA) (January-July)
Visiting FellowsJackson RJ, BSc(Hons) (Monash), PhD (Edin)
Lidbury B, BSc(Hons) (Newcastle), PhD (until June)Ramsay AJ, BSc, PhD (Otago)
Laboratory ManagerMedveczky CJ, AssocDipTechBiol (TAFE)
Senior Technical Offi cersMcArthur C, BSc (Flinders), MSc (from July)Shoobridge M, BSc(Hons)
Technical Offi cersGao K, BSc (ShanDong University), MPhilNolan L, BAppSci (UC)Woltring D, AssDipBiol (CIT), AssDipPath (CIT), BSc
Laboratory TechnicanDay S, BBioTech(Hons) (until February)
Viral Immunology and Molecular Virology GroupProfessor and Joint LeaderMüllbacher A, BSc, MSc (Auck), PhD
Fellow and Joint LeaderLobigs M, BSc(Hons), PhD
Research FellowLee E, BSc(Hons), PhD
Postdoctoral FellowRegner M, PhD
Visiting FellowsBassett ML, MB ChB (Otago), MD (Qld), FRACPBlanden RV, MDS (Adel), PhD, FAA (from January)Chin J, MSc(Hons) (Qld), PhD (Qld)Waring P, BSc(Hons) (Qld), MSc, PhDXu D, MD (Shandong Medical University, Jinan, China) (until February)
Senior Technical Offi cerKoskinen A, AssocDipMedSci
Technical Offi cersPavy M, AssDipAppSc (CIT)Papaminas A, BSc (UTS) (until July)Young N, BSc
Media/Wash-Up SectionManagerWoodhams CE, BAppSc (CCAE), GradDipInfSyst (UC)
TechniciansCarpenter JGilmartin L, Lab Skills Cert 3 (CIT)Thileebhan S (from November)Whiddon S, DipAppSci (CIT) (until May)
49
Staff 2004
Division of Immunology and Genetics
Australian Phenomics Facility (APF)Facility DirectorGoodnow CC, BVSc(Hons) (Syd), BScVet(Hons) (Syd), PhD (Syd), FAA
Head of OperationsMcKenzie A, BSc(Hons) (Monash)
Head of Finance and AdministrationBaker L, Bbus(Acc) (UnivTechSyd), CPA (Deakin)
Administrative Support Offi cerOvchynik K, BA (Charles Sturt) (from October)
Head of ProgrammingQuinn GF, BSc, GradDipComputing (CCAE)
Head of Scientifi c ProgramsBertram E, BSc(Hons) (Adel), PhD (Adel)
IT Offi cersGee A, BInfoTech (UC)McNeill JSatrapa A
Senior Colony CoordinatorSullivan K, AssocDipAppSci(Animal Science), AdvCertVet Nursing (CIT)
Pedigree CoordinatorChaudhry S, AssocDipAppSci(Animal Science) (CIT)
Phenotype CoordinatorWilliams M, DipAppSci (Animal Tech) (CIT) (until August)
Veterinary PathologistLepherd M, BVSc, DipLabTech (Path Testing) (until February)
Phenome Bank CoordinatorWhiting I
Senior Animal TechniciansRogis N, DipAppSci(Animal Tech) (CIT)White A, DipAppSci(Animal Tech) (CIT)Wilson J, AssocDipAppSci(Animal Science) (CIT)
Animal TechniciansAnderson C (from June)Avakian M, BSc (from October)Barich K (from October)Bodel R, DipAppSci(Animal Tech)Cooke S (until April)Craven A (from March)Dey B (from November)Dunn C (from February)Gambell R, DipAppSci(Animal Tech) (CIT)Horan J (from March)Kale M, BSc(Ag) (until July)
Lok A, DipAppSci(Animal Tech)McGhie K, DipAppSci(Animal Tech) (CIT), VetNursingCert IV (CIT)Palin A (March-July)Rankin S (from April)Reedy K, DipAppSci(Animal Tech)(until January)Rooke M, BMedSci (from October)Smith TVlazlovski DWebster K (from February)
Material Support CoordinatorHebda D
Support TechniciansAnderson S (until November)Hebda A (from June)Korres F (from November)Mullavey M (from October)Prewett B (from October)Smith DStagg M (from March)Webster J (until June)
IVF/Cryopreservation TechnicianAdams V, AdvCertVetNursing
Senior Cryopreservation ScientistSanchez-Partida G, PhD
Gene Mapping CoordinatorWhittle B, BSc(Hons) (60%)
Laboratory ManagerTownsend M, PathTech Cert (TAFE), AssDipAppPath (Bruce TAFE) (50%)
Mapping Technicians Buckle D, BSc (Melb), MSc (Auck)Yates A, BSc(Hons) (50%)
Screening TechniciansAthanasopolous V, PhD (Melb)Dawson S, BAppSci (50%)Dinsdale A, BSc(Hons) (until February)Ewing S, BiolTechCertHamilton A, DipPathTest (50%)Zarb J (until May) (50%)
Senior Screening TechniciansDomaschenz H, PathTechCert (TAFE)Howard D, BSc (50%)Kucharska E, BSc, MSc (Warsaw) (50%)
Visiting ScientistsCook M (Phenomix Pty Ltd)Liu C (Phenomix Pty Ltd)
50
Pres
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Nelms K, BSc (Missouri), PhD (Minnesota) (Phenomix Pty Ltd)Prasad S (Phenomix Pty Ltd)
Visiting TechniciansCraythorne R (Monash Institute of Research and Development)Douglas G (Monash Institute of Research and Development)Fitzgerald L (Phenomix Pty Ltd)Foster L, DipAppSci(Animal Science) (CIT) (Phenomix Pty Ltd)Glidden M (Phenomix Pty Ltd)Kennedy C (Monash Institute of Research and Development)Kofl er J (Phenomix Pty Ltd)
McEwan (Murdoch Childrens Research Institute)Manji S (Murdoch Childrens Research Institute)Shields E (Monash Institute of Research and Development)Sorensen B (Murdoch Childrens Research Institute)Stamp L (Monash Institute of Research and Development)Swain L (Monash Institute of Research and Development)Wernbacher L (Phenomix Pty Ltd)
Presentations 2004
Bertram Dr EMA switch in costimulation from CD28 to 4-1BB during primary versus secondary CD8 T cell response to infl uenza in vivoInternational Congress of Immunology, Montreal, CanadaThe Australian Phenomics Facility: Elucidating the phenome-genome codeMajor National Research Facilities; Showcasing Scientifi c Success roadshow, Canberra, Melbourne, Hobart, Adelaide, Perth
Chaudhri Dr GRole of tumour necrosis factor (TNF) in the immune response to poxvirus infectionsAustralian Health & Medical Research Congress, Sydney, NSW
Hoyne Dr GTracking autoimmune disease susceptibility from phenotype to gene4th National Microarray Conference, Perth, WAVisualizing the birth and development of antigen-specifi c treg cells in the thymusInternational Congress for Immunology, Montreal, Canada
Hulett Dr MThe heparan sulphate degrading enzyme heparanase: molecular characterisation and
targeting with drug inhibitors to treat cancer and infl ammatory diseaseUniversity of Newcastle, NSW
Karupiah Dr GImmunity to viral infections: Lessons from a poxvirus disease modelThe Barbara Ell Seminar Program, Victor Chang Cardiac Research Institute, Sydney, NSW
Lee Dr E Virulence attenuation of glycosaminoglycan-binding variants of fl aviviruses9th Arbovirus Research in Australia, Noosa, QLD
Parish Professor CCancer elimination by tumour-specifi c Th2 cells12th International Conference for Immunology, Montreal, CanadaNew approaches to cancer immunotherapyCentenary Institute, Sydney, NSWNew approaches to cancer immunotherapyChildren’s Cancer Institute Australia, Sydney, NSWNew approaches to cancer immunotherapyHanson Institute, Adelaide, SANovel approaches to inhibiting graft rejectionTransplantation Society of Australia and New Zealand, Postgraduate Training Course, Canberra, ACTHow to do science and make use of the discoveriesCRC for Vaccine Technology Annual Meeting
Division of Immunology and Genetics
51
Presentations2004
Heparan sulfate mimetics: A new class of anti-angiogenic and anti-metastatic drugsAustralian Health and Medical Research Congress, Sydney, NSWHeparan sulfate mimetics: A new class of therapeutic agentsMatrix Biology Society of Australia and New Zealand, Annual Meeting, Rottnest Island, WAImmunity to cancer7th Federation of Immunological Societies of Asia-Oceania Advanced Immunology Course, Adelaide, SAEosinophils: Key effector cells in anti-tumour immunity34th Annual Scientifi c Meeting of the Australasian Society for Immunology, Adelaide, SA
Ranasinghe Dr CFowl pox virus/vaccinia virus mucosal and systemic prime boost vaccine strategies in miceAustralian Centre for Hepatitis Virology and HIV Virology Conference, Barossa, SAHIV recombinant fowl pox virus/vaccinia virus mucosal and systemic prime boost vaccine trial in miceAustralian Society for HIV Medicine Conference, Canberra, ACT
Rao Dr SElucidating the global mechanisms of transcriptional regulation in mammalian systemsThe University of Melbourne, Melbourne, VIC
Simeonovic Dr CJMediators of islet xenograft rejection22nd Annual Scientifi c Meeting of the Transplantation Society of Australia and New Zealand, Canberra, ACT
Vinuesa Dr CGRoqin negatively regulates follicular T cell help for self reactive germinal centre B cells34th Annual Scientifi c Meeting of the Australasian Society for Immunology, Adelaide, SA
Follicular T cells and autoimmunity2nd Australian Health and Medical Research Congress, Sydney, NSWRoqin: A novel regulator of T cell toleranceCentenary Institute, Sydney, NSWSystematic analysis of gene variants causing immunodefi ciency and autoimmunityXIth Meeting for the European Society for Immunodefi ciencies, Versailles, FranceRoqin: A novel regulator of T cell toleranceAustralasian Society for Immunology New South Wales Branch Conference, Wisemans Ferry, NSWAn ENU-based genome survey for autoimmunity alleles reveals a critical role for Roqin in the pathogenesis of a lupus-like syndrome with autoimmune thrombocytopenia12th International Congress of Immunology and 4th Annual Conference of FOCIS, Montreal, Canada
Simson Dr LThe role of Th2-mediated immunity in tumour immunosurveillanceTumour Immunology Workshop, Australasian Society for Immunology, Adelaide, SA
Thomson Dr SANew HIV and HCV vaccine candidates and delivery strategiesAustralian Society for HIV Medicine, Canberra, ACT and Immunology Group Victoria, Beechworth, VICHCV Vaccine CandidatesAustralian Health and Medical Research Congress, Sydney, NSW
Warren Dr HSInnate immunity – NK cells in transplantationPostgraduate course of the Transplantation Society of Australia and New Zealand, Canberra, ACTAnalysing human natural killer (NK) cell receptorsWestmead Millenium Institute, Westmead, NSW
Division of Immunology and Genetics
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Staff 2004
Division of Molecular Bioscience (DMB)
Professor and Head of DivisionShannon MF, BSc(Hons), PhD (National University of Ireland)
Divisional Technical ManagerTaylor R
Divisional AdministratorMitigas R
Assistant AdministratorFunari R
Divisional Visiting FellowsArmarego WLF, PhD, DSc (Lond), FRSC, FRACIBarlin G, PhD, DSc (Sydney), FRANCMorrison JF, BSc (Syd), MSc (Qld), DPhil (Oxon), DScCox G, BSc, PhD (Melb), FAAGibson FEW, BSc, DSc (Melb), MA, DPhil (Oxon), FAA, FRSShaw D, BSc (WA), PhD (Cantab) (until November)Denborough M, MD, ChB (Capetown), MD (Melb), DPhil (Oxon), DSc (Melb), FRCP
School VisitorSpinner E, MScTech, PhD, DSc (Manc), FRACI
Laboratory Stores AttendantMurray E
Allergy and Infl ammation Research GroupSenior Fellow and LeaderFoster PS, BSc(Hons) (WA), PhD
Research FellowsHogan S, BSc(Hons), PhD (until May)Webb D, BAppSci, PhD (UC)
Postdoctoral FellowsPhilpps S, PhD (London)Newcombe N, PhD (University of Newcastle)Yang M, PhD
Visiting FellowDenborough M, MD, ChB (Capetown), MD (Melb), DPhil (Oxon), DSc (Melb), FRCP
Technical Offi cerCai Y, BMed (Beijing Medical University)
Autoimmunity and Genetics LaboratorySenior Fellow and LeaderSlattery R, BSc(Hons), PhD (Melb) (until February)
Laboratory TechnicianPalmer S, BSc(Hons), GradDip(Tech Management)
Laboratory AssistantsSpitaler RKofl er J
Biomolecular Structure LaboratoryFellow and LeaderCasarotto MG, BSc(Hons) (Melb), PhD (Melb)
Postdoctoral FellowsCui Y, MA (Central China University), PhD (Chinese Academy of Science) (from July)Harvey P, BSc(Hons) (Griffi th), PhD (Griffi th)Heidari R, MscAg, PhD (until October)
Technical Offi cersSutherland T, BAppSci, (Charles Sturt) (until January)Morris M, BBiomedSci(Hons) (James Cook)Norris N, BSc (ANU) (Hons) (Syd)Karunasekara Y, MD (USSR)
Chromatin and Transcriptional Regulation LaboratoryFellow and LeaderTremethick DJ, BSc(Hons) (Syd), PhD (Macq)
Research FellowsRidgway P, BSc (McMaster, Canada), MSc (Queens, Canada), PhDFan J, BSc (Fudan, China), MSc (Fudan, China), PhD (Auckland, NZ)Rangasamy D, BSc, MTech (India), PhD (Hull, UK)
Postdoctoral FellowGreaves I, PhD
Technical Offi cerPrashadkumar S, BSc, PostGradDip(Reproductive Science), Masters INR Science (until July)
Laboratory TechniciansPowell M, BSc (UC) (from March)Young S (casual)
Computational Proteomics and Therapy DesignSenior Fellow and LeaderGready JE, BSc(Hons), PhD (Syd), FRACI
Research Offi cerCummins PL, BSc(Hons), PhD (Syd)
Computer Offi cerMiller S, BFilmMedia (MIT)
Postdoctoral FellowsGillies MB, BSc(Hons) (Syd), PhD (Utrecht) (until March)Kannappan B, BSc (Madras), MSc, PhD (Pune)Watson S, BSc, PhD (Wales) (until December)Zelensky A, BSc, MSc (Kiev-Mohyla) (from October)
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Division of Molecular Bioscence
Laboratory TechniciansDamcevski VW, AssDipAppScience (CIT)Taylor HINewhouse MJ, BSc, Grad DipLangton LK, BSc, AssDipSc. (part-time)Kugathas K, DipMedLabSci (CIT)Young S (part-time).
Membrane Physiology and Biophysics LaboratoryProfessor and LeaderGage P, MB CHB (NZ), PhD, DSc (NSW), FAA
Postdoctoral FellowsOzsarac N, BSc(Hons), PhD (from July)Wu W, BSc, PhD
Visiting FellowsEwart G, BSc(Hons), PhDTierney L, BSc(Hons), PhD
Technical Offi cerCurmi J, BOptom(Hons)Liu L, BSc, PhDLeves F, BSc(Hons)Weiss S, BAppSc, PhD, Mfi nMgt
Molecular Genetics GroupProfessor and LeaderBoard P, BSc(Hons), PhD (UNE)
Research FellowsBlackburn A, BSc(Hons) (UNSW), PhDFan Y-Y, BMed (PR China), PhD (Adel)
Postdoctoral FellowsMasoumi A, BSc (National University of Iran), MSc (UNE), PhD (until June)Shield A, BBiotech(Hons) (Flinders), PhD (Flinders)
Visiting FellowsCavanaugh J, BSc, MS (North Carolina State), PhDClarke A, PhD (Victoria University, Wellington) (from October)Dahlstrom J, MBBS(Hons) (Syd), PhD
Senior Technical Offi cerCoggan MA, BSc(Hons)
Laboratory TechniciansBrew J (part-time)Bessell RCappello J, BSc(MedLabSci) (UC), AD AppSciAnSci (CIT)Kaskarov U, MSc (Kazan State University, Russia)Karunasekara Y, MD (Vinnitsa Medical Institute, Ukraine)
Research AssistantVassilieva T, MSc (Novosibirsk)
Visiting FellowsBliznyuk A, BSc, PhD (Novosibirsk)Rostov I, BSc (Kazan), PhD (Karpov Institute)Graves JAM, BSc, MSc (Adel), PhD (UC Berkeley)
Cytokine Gene Expression LaboratorySenior Fellow and LeaderShannon MF, BSc(Hons), PhD (National University of Ireland)
Postdoctoral FellowsJuelich T, BSc (Hons) (Uni Stuttgart, Germany), PhDWilkinson N, PhD (Uni of Texas)Wang J, BSc (Xinjiang), MSc (Weizmann Institute, Israel), PhDPremzl M, DVM, MSc (University of Zagreb, Croatia) (from September)
Technical Offi cersWoltring D, AssDipBiol (CIT), AssDipPath (CIT), BSc (until February)Beatty A, BAppSci(MedSci) (UC)Elsum I, (April to September)
Cytokine Molecular Biology and Signalling GroupProfessor and Group LeaderYoung IG, MSc (Melb), PhD
Postdoctoral FellowsSoboleva T, MSc (MSU), PhDChen J, Master of Medicine (China), PhD (Flinders) BSc (China)
Research AssistantFord S, BA, MSc (Qld)
Technical Offi cersOlsen J, BScConlan F, BSc(Hons) (Wollongong)Young M, BSc(Hons) (Otago) (until February)
Visiting FellowSobolev ASDept of Biophysics, Moscow State University
Gene Targeting LaboratorySenior Fellow and LeaderMatthaei KI, BSc(Hons) (UNSW), PhD
Visiting fellowWhitten WK, BVSc(Hons), BSc, DSc
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Division of Molecular Bioscence
Murray T, BSc(Hons) BMedSci (Syd)Papaminas A, BSc(BioSci) (UTS)Triffett D, BBiotech(Hons) (Flinders)
Visiting StudentWarren A, BSc (Hons), MSc
Muscle Research GroupProfessor and Group LeaderDulhunty A, BSc (Syd), PhD, DSc (NSW)
Postdoctoral FellowsPouliquin P, BSc(Hons) (Ferrara, Italy), PhD (Montpellier II, France)Beard N, BAppSci(Hons) (La Trobe), PhDKimura T, BSc(Hons) (Osaka, Japan)
Visiting FellowsLaver D, BSc(Hons), PhD (UNSW)Gallant E, PhD, (Minnesota, USA)
Technical Offi cerCurtis S, BSc, PLTC (50%)Karunasekara Y
Senior Technical Offi cerPace S, BSc (UTS)
Laboratory TechniciansStivala JWatson S (until June)
Ubiquitin LaboratoryFellow and LeaderBaker R, BSc(Hons) (UNSW), PhD
Technical Offi cerMcIntyre M, BSc(Hons) (UWA), GradDipEd Secondary Science (UC)
Laboratory TechnicianSinghal S, BSc(Hons) (Delhi), MSc(BioTech) (Panjab, India)
Visiting ScholarBelbin B, BSc(Hons) (Memorial University of Newfoundland) (from November)
Baker Dr RTRoles of deubiquitylating enzymes in ubiquitin-dependent processes59th Harden Conference, Cirencester, UKThe deubiquitylating enzyme Usp2-69 modulates cell cycle regulatory activity of Ras effectors RASSF1A and RASSF1CComBio2004, Perth, WA
Board Professor PWFunctional polymorphism of Alpha and Omega class glutathione transferases15th International Symposium on Microsomes and Drug Oxidations Mainz, GermanyMitochondrial glutathione transferase Kappa represents a third distinct family of mammalian glutathione transferases7th International ISSX conference, Vancouver, CanadaFunctional polymorphism of omega class glutathione transferasesPharmacogenomics, Cold Spring Harbor, NY, USA
Characterization of omega class GST variantsDepartment of Molecular and Cellular Biology University of Arizona, Tucson, USA
Foster Professor PSChair Mini-symposium (educational section): Role of arginase in asthma The American Academy of Asthma, Allergy and Immunology 59th annual meeting, San Francisco, USAInvited speaker Collegium Internationale Allergologicum, 25th International Symposium, SwedenInvited speaker12th International Congress on Immunology, Montreal, CanadaUnderstanding the pathogenesis of asthmaWoolcock Institute of Respiratory Medicine, University of Sydney, NSWAsthma and the ageingMacquarie Bank National Asthma Foundation, Blue Mountains, NSW
Presentations 2004
55
Presentations2004
Division of Molecular Bioscence
Invited speakerInternational Symposium on Infl ammation: from Cellular Immunity to Human Disease. Monash Institute of Reproduction and Development and the Southern Clinical School of Monash University, Melbourne, VICInvited speakerAustralasian Society for Free Radical Research, Annual Scientifi c Meeting University of Canterbury Medical School, Christchurch, NZInvited speaker8th International Conference on Human Leucocyte Differentiation Antigens and 34th Annual Scientifi c Meeting of the Australasian Society for Immunology, Adelaide, SA
Gready Professor JEDevelopment and troubleshooting of semiempirical QM/MM coupling terms for enzyme simulation applicationsMichael Dewar Memorial Symposium on Semiempirical Methods, 227th American Chemical Society National Meeting, Anaheim, USACharacterization of transient long-range conformational substructure in ‘disordered’ prion protein repeat peptides probed by combined use of FRET measurements and MD simulations1st Pacifi c Rim International Conference on Protein Science (PRICPS2004), Yokohama, JapanCharacterization of transient conformational substructure in “disordered” peptides of prion protein by experiment and MD simulationMolecular Modelling Workshop (MM04), Sydney, NSW
Matthaei Dr KIGene knockout mice: The answer or a problemAustralian and New Zealand Microcirculation Society, 11th Annual Meeting, Kingfi sher Resort Fraser Island, QLD
Human therapeutic cloningSeminar and Panel discussion: Human Therapeutic Cloning, Australian & New Zealand Medical Boards Annual Conference, Canberra, ACTChemokine knockouts and the allergic phenotype.Discussion leader: 60th American Academy of Allergy Asthma and Immunology Annual Meeting, San Francisco, USAGene knockout mice: The answer or a problemDepartment of Pharmacology, University of North Carolina, Chapel Hill, NC, USAGene knockout mice: The answer or a problemFaculty of Medicine, University of Bonn, Germany
Ridgway PEmbryonic stem cells: Pathways to cell specialisationAustralian Academy of Science AGM social program, Canberra, ACT
Shannon Professor MFNF-kB, biology and pathologyWorkshop speaker — Keystone ConferenceTranscriptional regulatory mechanismSymposium Speaker, COMBIO Conference, Perth, WAInvited Speaker4th National Microarray Conference, Perth, WAT cell Symposium speaker, Australian Society for Immunology Annual Conference
Tremethick Dr DJChromatin structure and functionChair and Speaker: Gordon Conference
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Staff 2004
Division of Neuroscience (DNS)
Professor and Head of DivisionHill CE, BSc, PhD, DSc (Melb)
School Technical Support Offi cerTaylor R
Divisional AdministratorsLukatela M, BA ModLang, GDipLib (CCAE)McNaughton E (Casual)
Divisional AssistantsWickham G
Autonomic Neuroeffector Transmission LaboratoryProfessor and LeaderHirst GDS, BSc, PhD (Leeds), FAA
Senior Research FellowEdwards FR, BE, PhD (Monash)
Postdoctoral FellowYanagida H, MD, PhD (Nevada)
Technical AssistantGarcia London AP, BVSc (Caldas) (from March)
Blood Vessel LaboratoryProfessor and LeaderHill CE, BSc, PhD, DSc (Melb)
Postdoctoral FellowsGoto K, PhD, MD (Kyushu)Grayson T, BSc (Tas), MSc, PhD (Plymouth)
Senior Technical Offi cersBrackenbury T, PhD, MSc, BSc(Hon), BSc (Natal)
Research Offi cerBelfrage K, BSc(Hons) (La Trobe) (from March)
Brain Modelling LaboratoryARC Senior Research Fellow and LeaderClements JD, BSc (Monash) PhD
Postdoctoral FellowSylantyev S, MSc, PhD (Odesa) (from July)
Cerebral Cortex LaboratorySenior Research Fellow and LeaderBekkers JM, BSc (Griffi th), MSc (Manchester), PhD (Cambridge)
Postdoctoral FellowsSuzuki N, BSc (Tsukyba), PhD (Tokyo) (from April)
Developmental Neurobiology LaboratoryProfessor and LeaderHendry IA, BSc (Med), MBBS (Syd), PhD (Cambridge)
Laboratory TechnicianHolgate J, BAppSc (UC)
Visiting FellowMegirian D, MS, PhD (Rochester)
Movement and Memory LaboratoryProfessor and LeaderRedman SJ, ME (NSW), PhD (Monash), DSc (Monash) FAA
University Fellow and Emeritus ProfessorCurtis DR, AC, MBBS (Melb), PhD, FRACP, FAA, FRS
Research FellowsSong Z-M, MSc (Jiamusi), PhD (Flinders)Raymond C, BSc(Hons) (Otago), PhD (Otago)
Postdoctoral FellowHu J, MD, PhD (Zhongshan)
Senior Technical Offi cerRodda GR, PTC
Neuronal Network LaboratoryAssociate Professor and LeaderStricker C, MD (Zurich), PhD (Bern)
Research FellowCowan AI, BSc(Hons), PhD
Visiting StudentsErtz S, (ANU Medical School)Austin-Woods C, (ANU Medical School)
Neuronal Signalling LaboratoryWellcome Trust Senior Research Fellow and LeaderStuart G, QEII Fellow, BSc (Monash), PhD
Postdoctoral FellowsGulledge A, BSc(Hons) (Uni California), PhD (Texas)Kampa K, DipBiol (Freiburg), PhD (from May)Kole MHP, MSc, PhD (Groningen)
Synapse and Hearing LaboratoryProfessor and LeaderWalmsley B, BE, PhD (Monash), DSc (NSW)
Research FellowOleskevich S, BSc(Hons), PhD (Montreal) (until June)
Visiting FellowNicol MJ, BSc (Wollongong), (Hons), PhD
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Presentations 2004
Division of Neuroscience
Postdoctoral FellowBerntson A, BA (Minnesota), PhD
Research Assistant (part-time)Webb D, BSc (NTU), MSc(Prelim) (Syd)
Visual Neuroscience LaboratoryProfessor and LeaderLamb TD, BE (Melb), ScD (Cantab), FRS
Bekkers Dr JFrom vesicles to epilepsy: The synaptic vesicle cycle in hippocampal cultures, and the electrophysiology of GalnR1-/- epileptic miceGarvan Institute, Sydney, NSWPresynaptically-silent synapses and dendritic pruning in the hippocampus and cerebellumMelbourne University, Melbourne, VIC
Berntson Dr ACalcium channels and calcium handling in MNTB neurons of deaf miceKioloa Neuroscience Symposium, NSWReduced Kv1 but normal Cav expression in the auditory brainstem of congenitally deaf miceAustralasian Winter Conference on Brain Research, Queenstown, NZThe neurobiology underlying hearing and deafnessUniversity of the Third Age, Hughes, ACT
Clements Dr JSynaptic transmissionUniversity of NSW, Sydney, NSW
Goto Dr KChanges in endothelium-derived hyperpolarizing factor in hypertension and ageing: response to chronic treatment with renin-angiotensin system inhibitorsSymposium: Endothelial dysfunction and vascular disease, Joint meeting of Australian Physiological and Pharmacological Society and NZ Physiological Society, Sydney, NSW
Hendry Professor IAdvances in retrograde transport: functions and mechanisms of retrograde neurotrophin signalling Symposium Chair: International Society for Developmental Neuroscience, Edinburgh, ScotlandIntracellular communication and axon outgrowthSymposium Chair: Australian Health and Medical Research Congress, Sydney, NSWBehavioural effects of Gz deletion: implications for coupling to dopamine and serotonin receptorsAustralian Neuroscience Society, Melbourne, VICEffects of Gaz deletion: implications for analgesic toleranceAustralian Pain Society, Canberra, ACTProteins associated with the neurotrophin retrograde transport organelleInternational Society for Developmental Neuroscience, Edinburgh, Scotland, UKFactors affecting retrograde axonal transport of neurotrophinInternational Congress of Eye Research, Sydney, NSWHas the multivesicular body containing the neurotrophin retrograde transport organelle other components?Australian Health and Medical Research Congress, Sydney, NSW
Presentations 2004
Postdoctoral FellowsCameron AM, BPsych(Hons) (JCU), PhD (UQ)Jarvinen J, MSc (Helsinki), PhD (Cantab) (from February)
Computer ProgrammerMiao L, BEngEIE (Tongji), MEngTel (until August)
Visiting Fellow and Emeritus ProfessorLevick WR, MSc, MBBS (Syd) PhD, FOSA, FAA FRS
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Hill Professor CGap junctions and endothelial function in hypertensionSymposium: Control of vascular tone in health and disease, Australian Health and Medical Research Congress, Sydney, NSWCritical role for potassium channels and gap junctions in vasomotor functionUniversity of Wisconsin, USACritical role for potassium channels and gap junctions in vasomotor functionYale University School of Medicine, New Haven, CT, USA
Hirst Professor DInvolvement of ICC in control of gastric motilityPlenary Lecturer, American Motility Society, Nashville, TN, USAOrder in the autonomic nervous systemPlenary Lecturer, Smooth Muscle in Health and Disease, Port Douglas, QLDAn electrical description of the generation of slow waves in the gastric antrumPlenary Lecturer, Irish Motility Society, Belfast, Ireland
Lamb Professor TProperties of human photoreceptors determined from the ERGNeuro-Ophthalmology Society of Australia, 20th Meeting, Melbourne, VICDark adaptation and the retinoid cycle of vision: molecular basis of slowed dark adaptation in a range of retinal conditionsNeuro-Ophthalmology Society of Australia, 20th Meeting, Melbourne, VICRecovery of photoreceptor responsiveness following intense bleaching exposures Biophysical Society of Japan, Kyoto, Japan
Division of Neuroscience
Redman Professor SJCalcium buffering in nerve terminalsRetirement symposium for Phillip Nelson, National Institutes of Health, Bethesda, MD, USACalcium buffering in motoneuronesSmooth Muscle in Health and Disease, Port Douglas, QLD
Stuart Dr GAction potential initiation and propagation in neuronsUniversity of Lund, SwedenActive dendritesDendritic Patch-Clamp Workshop, University College London, UKDendritic mechanisms underlying synaptic plasticityFederation of European Neuroscience Meeting, PortugalAction potential initiation and propagation in cortical pyramidal neuronsGordon Conference on Synaptic Transmission, USAHow the brain works from a single neuron point of viewMajor National Research Facilities meeting, Canberra, ACTInitiation and backpropagation of action potentials in central neuronsAustralian Health and Medical Research Congress, Sydney, NSW
Walmsley Professor BSynaptic Transmission in the Auditory BrainstemAuditory Colloquium, Melbourne, VICSynaptic Transmission in the Mammalian Central Nervous SystemSmooth Muscle in Health and Disease, Port Douglas, QLD
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Staff 2004
Staff 2004
Professor and HeadWhitworth JA, AC, DSc, MD, PhD, BS (Melb), MD (Honoris causa) (Syd), FRACP, FAICD
Postdoctoral FellowsSchyvens CG, BSc (Syd), PhD (NSW) (until September)Zhang Y, BMed (Beijing), PhD (Adelaide)
Senior Technical Offi cerMcKenzie K, AssDipAppSci(Animal Sci), Cert III, IT (CIT)
Research AssistantWilliamson PM, SRN (seconded to St George Hospital, Sydney)
High Blood Pressure Research Unit (HBPRU)
Presentations 2004
Whitworth Professor JA2003 World Health Organization (WHO)/International Society of Hypertension (ISH) statement on management of hypertension20th Scientifi c Meeting of the International Society of Hypertension, Sao Paulo, BrazilGlucocorticoids, Hypertension and Nitric Oxide20th Scientifi c Meeting of the International Society of Hypertension, Sao Paulo, BrazilGuidelines for treatment. Highlights, Similarities and DifferencesWorld Heart League meeting. 20th Scientifi c Meeting of the International Society of Hypertension, Sao Paulo, BrazilHypertension in PregnancyAsian-Pacifi c Congress of Nephrology, SingaporeHypertension in Renal Disease and DiabetesAsian-Pacifi c Congress of Nephrology, SingaporeCardiovascular disease control and life years gained … the role of researchInternational Conference on Longevity, Sydney, NSWResearch and Health2004 Asia Pacifi c Rim Universities (APRU) Doctoral Students Conference, University of Sydney, NSWAustralia Day Address Order of Australia Association, Canberra, ACT
Visiting FellowsKelly JJ, MBBS(Hons), MD (NSW)Schyvens CG, BSc (Syd), PhD (NSW) (from September)
Visiting ScholarsKiiza CM, MB ChB, MMed (July – October)Guo J, BMed (May – July)Miao Y, BMed (from July)
Guest dinner speakerLiberal Party Women, Canberra, ACTWomen of Infl uence lectureANU Equity and Diversity, Canberra, ACTSpeakerHealth and Rehabilitation Services, SRC Conference, Sydney, NSWGraduation Ceremony Occasional AddressUniversity of Sydney, Sydney, NSWScientist and SocietyFantastic Monday Mornings, Prospects for PhD’sSydney, NSWCapstone Leadership Program AddressDepartment of Defence, Canberra, ACTWomen, Medicine and ResearchACT Medical Women’s Society, Canberra, ACTAddressNZ Health Leaders Program, Canberra, ACTAddressStaff Development Dinner Speech,St Michaels Grammar School, Melbourne, VICGlucocorticoid Hypertension — just say NOA tribute to Trefor Morgan, Melbourne, VICSandford Jackson Memorial LectureNorth Queensland AMA, Medical Conference, Townsville, QLD
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Professors and Co-DirectorsEasteal S, BSc (St Andrews), PhD (Griffi th)Wilson SR, BSc(Hons) (Syd), PhD
ProfessorWelsh A, BSc(Hons) (Sydney), PhD
FellowsHuttley GA, BSc(Hons) (Macquarie), PhD (California)Isaev A, MSc, PhD (Moscow)
Research FellowsBooth H, BSc (Adel), PhD (UNE)Burden CJ, BSc(Hons) (Qld), PhDFang Y, BSc, MSc (Jilin), PhD (Massachusetts)Maindonald JH, MSc (NZ), PhDWakefi eld M, BSc(Hons) (Melb), PhD (La Trobe)
Postdoctoral FellowsSantosa L, BEng(Hons)/BSc (Melb) PhD (Melb)Pittelkow Y, BA DipEd (Macquarie), Grad Dip Stats (UC), MSc, DipArts, PhD
Visiting FellowsRobinson A, BSc (Hons), PhDNunney L (November-December)
Scientifi c ProgrammersButterfi eld A, BSc(Hons) (Canterbury NZ)Lang ELawrence C, BSc(Hons), MA (Delaware), GradDipCompSci (UNSW)Maxwell P, MSc, DipCompSci (Auckland)
Administrative AssistantGuernsey B
Staff 2004
Centre for Bioinformation Science (CBiS)
Presentations 2004
Booth Dr HSDiscussion of a bayesian approach to DNA sequence segmentationXXIInd International Biometric Conference and Australian Statistical Conference, Cairns, QLDModelling gene regulation using the stochastic master equationBioInfoSummer 2004, Canberra, ACT
Huttley Dr GAModeling the impact of DNA methylation on the evolution of BRCA1Annual meeting of the Society for Molecular Biology and Evolution, Pennsylvania State University, PA, USAIs adaptive modifi cation to BRCA1 a common feature of placental mammal evolutionAnnual Evolution Society Meeting, Colorado State University, Ft Collins, CO, USAComparative Genomics ToolkitColorado State University, Boulder, CO, USACentre for BioInformation Science (CBiS): OverviewNICTA Biotechnology Sector Mapping Activities Workshop
Isaev Dr AExamples of unbounded homogeneous domains in complex spaceInternational Conference on Several Complex Variables and Complex GeometryCapital Normal University, Beijing, ChinaFinite and Infi nite Dimensional Complex Analysis and ApplicationsICU, Tokyo, Japan
Maindonald Dr JHSelection Bias Effects in the Graphing of High-Dimensional DataUniversity of Western Australia, WAThe Human Eye + Data + TheorySydney Summer Statistics Workshop, Sydney, NSWThe Use of Variance Information in the Analysis of Microarray DataInternational Biometrics ConferenceSelection bias in the plotting of microarray or other data that have been sampled from a high-dimensional space12th Biennial Computational Techniques and Applications Conference, Melbourne, VIC
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Centre for Bioinformation Science
Disinfestation Research – Context, Science and StatisticsRichard Morton meeting, Canberra, ACTGraphs of Samples of Microarray Data, Designed to Show Known Prior Groupings BioInfoSummer 2004, Canberra, ACT
Santoso Dr LThe probability of pacman and pinocchio – stochastic modelling of endocytosisICE-EM Winter School in Computational Biology, The University of Queensland, QLDTo lyse or not to lyse - a case study of genetic switches5th Biennial Asian Control Conference, Melbourne, VICSimulation and modelling of gene switches12th Biennial Computational Techniques and Applications Conference, Melbourne, VICMarkov modelling of gene switchesSecond Annual Bringing Biosciences Together Conference, Canberra, ACT
Wakefi eld Dr MJVestige, maximum likelihood phylogenetic footprintingLorne Genome Conference, Lorne, VICThe Kangaroo Genome ProjectLudwig Bioinformatics Conference, Melbourne, VICMolecular Biology Tools and TechniquesBioInfoSummer 2004, Canberra, ACT
Welsh Professor ALikelihood Methods for SurveysUniversity of Southampton Robust Model SelectionBeijing Normal University, Beijing, ChinaRobust Model SelectionNSW Branch Statistical Society of Australia Inc
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PhD ScholarsAbraham M, BSc (Tas), MPhil
Alonso H, MSc (Cordoba)
Alsharifi M, BBioMedSci(Hons) (Monash)
Arsov T, MD (St Cirilus and Methodius Univ, Skopje, Republic of Macedonia), MS (St Cirilus and Methodius Univ, Skopje, Republic of Macedonia)
Azmanov D, MD (Thracian University, Stara Zagora, Bulgaria) (from April)
Barlow V, BSc(Hons), LLB , LLM (UTS), GradDip Legal Practice (College of Law NSW) (until July)
Berg H, BSc(Hons)
Bowman L, BSc(Hons)
Brown K, BSc(Hons) (Murdoch)
Bunting K, BSc(Hons)
Calanni S, BSc(MedSci) (Syd), BSc(Hons)
Chakka N, BDS (Bangalore) MSc (Bioinformatics) (EastAnglia)
Chen X, BSc(Hons)
Correcha M, MBBS (Univ of Cauca, Colombia)
Dai Q, MSc (UNSW) (until September)
Day S, BBioTech(Hons) (from July)
De Mestre A, BVSc(Hons) (Syd)
Derrick G, BSc(Hons)
Dixon C, BSc(Hons)
Easton B, BSc
Eichner D, BSc(Hons)
Ellis L, BAppSci (UC) (from February)
Ellyard J, BAs, BSc(Hons) (from March)
Farnsworth M, BSc (Wollongong), BSc(Hons)
Flening E, BSc(Hons) (UNSW) (from February)
Forbes E, (BSc)
Franklin A, BSc(Hons)(Wollongong) (until May)
Gousseva N, BSc (Moscow) (until July)
Haddock R, BSc (Wollongong), BSc(Hons)
Halliday D, BSc (Townsville) (until March)
Harley N, BSc(Hons)
Harrison J, BSc(Biomed Sci)(Hons) (Adel)
Hill K, BMed&AppBiotech(Hons) (Charles Sturt) (from February)
Hyun M, BSc, MSc (Yonsei)
Ikeda K, BA (Colorado)
Jing J, MMath (Jilin University, China)
Jones A, BScAgr(Hons) (Syd) (until May)
Jun J, BMedSc(Hons) (Syd) (until March)
Kwok A, BSc(Hons)
Leao R, BSc, MD (UFU, Brazil)
Letzkus J, MBiol (Mainz)
Lim C, BTech(Hons), (Auckland)
Liston A, BSc(Hons) (Adel)
McColl C, MBBS (Melb) FRACP
McCuaig R, BSc (UC), GradDipSciMolBiol (ANU), BSc(Hons) (Univ of Tasmania)
McNamara S, BSc
Monroe H, BSc (SA)
Moore A, BSc(Hons), (Massey)
Murase T, BSc(Hons)
Navarro M, BVSc (Caldas)
O’Rance L, BMedSci(Hons) (Syd)
Palmer L, BA, BSc (Melbourne), MS (Minnesota)
Panchanathan V, MBBS, MPhil (University of Malaya) (until July)
Papathanasiou P, BSc(Hons), LLB (until April)
Pittelkow Y, BA, DipEd (Macquarie), GradDipStats (UC), MSc, DipArts
Premzl M, DVMed, MSc (Zagreb) (until Sept)
Prichard Z, BSc(Hons) (from March)
Robbins S, BSc(Hons) (UC) (until September)
Sammut R, BAppSc (Monash), BEc(Hons) (Monash)
Schmuck E, BSc(Hons) (Nancy, France), DipIng Biotech (Germany)
Scott B, BSc, PGDip (UQ)
Sharkhuu T, MSc, Mongolia, UK
Sjollema G, BSc (from June)
Smart V, BSc(Hons)
Socha LH, MD (Colombian National University), GradCertClinicalTrials Management (UC)
Soe-Htwe T, BA (Cornell) (from September)
Sutcliffe E, BSc(Hons)
Svahn K, BSc, MSc (Gothenburg)
Taylor M, BSc, MPhil
Wang K, BSc (Auckland)
Wang Y, MB (Beijing Medical University), MM (Syd) (until June)
Students at JCSMR
63
Rese
arch
Pro
gram
s
63
Wood R, BSc(Hons) (JCU)
Wu, Z, MSc (UNSW), BM (ZhongShan Medical University, China) (from March)
Yamada T
Youssoufi an M, BSc (California), BSc(Hons)
Yu D, BSc (Wuhan Univ, China)
Zeid OA, MD (Cairo)
Zelensky A, BSc, MSc (Kiev-Mohyla) (until October)
Zhang J, BMSc (Hunan)
Zhou J, MD (Guang Xi Medical University)
Ziolkowski A, BSc(Hons) (from March)
PhB ScholarsBatley S
Ramanayake R
MPhil ScholarsHu L, BMed (Shanghai)
Sakala I, BMedSc (Univ Zambia) (from July)
Graduate Diploma ScholarsCassella C, BSc (Pepperdine)
Holgate J, BAppSc (UC)
Honours ScholarsChan R
Devoy M, BSc
Giummarra N, Bsc
Horan C, BSc
Johnston K, BSc
Jozwick C, Bsc
Lam E
Nagaraja N, BMedSc
Ng E, BMedSc
Otheris O, BMedSc (until September)
Park S, Bsc/Bpsych
Prosselkova G
Sheahan D, BSc
Tam C, BSc
Tan A, BBioTech
Vanrijswijk P, Bsc
Zhou Z, BMedSci
International ScholarsDe Melo Naves, MOstberg, KSHu, LMiao, Y
Vacation ScholarsBriggs, J
Cheung, S
French, S
Fu, S
Gasparini, C
Guo, L-J
Ho, M
Johnston, K
Kwa, AAF
Lawless, K
Lee, L
Liew, WC
Lim, C
Lindsay, H
Linterman, M
Nandapalan, N
Neilson, J
Pang, M
Park, T
Rosenberg, M
Scolaro, L
Sharma, A
Sheridan, M
Sutherland, D
Tan, C
Thomas, A
Walker, A
Williams, H
Students
Students 2004
64
Staf
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04 School Administration & Services
School AdministrationHoward Florey Professor of Medical Research
and DirectorWhitworth JA, AC, DSc, MD, PhD, BS (Melb), MD (Honoris causa) (Syd), FRACP, FAICD
Deputy DirectorRedman SJ, ME (NSW), PhD (Monash), DSc (Monash) FAA
Business ManagerWebb B, AdvDipBusMan (CIT)
School VisitorFenner Emeritus Professor F, AC, CMG, MBE, FRS, FAA, MD, DTM, Hon Md, Dr honoris causa (Univ Liege), FRACP, FRCP (Lon)
Convenor, Graduate Program in Medical
SciencesRoss V, BA, BLitt, PhD
Public Affairs Offi cerNicol MJ, BSc (Wollongong) (Hons), PhD
Safety & Training Offi cerCregan A, BSc
Executive Assistant to DirectorJacobsen AJ
Administrative AssistantsArnold JMorales D
School ServicesAnimal ServicesHeadMetcalfe C, Cert Vet Nursing, Cert Frontline Management (Acting) (until September)Reid A, MIAT (UK) HNC Biological Sciences (from September)
Deputy Head Metcalfe C, Cert Vet Nursing, Cert Frontline Management (Acting) (from September)
Offi ce AdministrationHargrave T (part-time)Khan P
Divisional VeterinarianBain SAF, BVSc (Syd), MACVSc (part-time)
Senior Technical Offi cerGooding D
Technical Offi cersComans CRichardson JSutton M
Animal TechniciansBarancewicz N (part-time)Bowes VBurke BBurke HCox SDutton KFaucett TFigueroa SFook NMartin JTulsiani S (part-time)Williams N
Material Support TechniciansCover GForgie IHamilton RHogan PJarvis LPorritt TSantrac CViolante OYoung S (part-time)
School Administration School Services
65
Staff 2004
Biomolecular Resource Facility (BRF)ManagerEdwards K, BSc (Natal), BSc (Hons) (Cape Town), PhD (London), GradCert Tertiary Teaching (JCU), MEnvMng (UNE)
Technical SpecialistMilburn P, BSc (HOAS), PhD (Sheffi eld)
Microarray CoordinatorsPeng K, PhD (Wuhan) (from June)Vavrina A, BMedSci (50%, April-October)Wilson H (part-time)
Bioinformatics AnalystOhms S, MBChB, ME, PhD (Auckland)
DNA sequencingMcCrae C, BiolTech Cert (CIT)Scott B, BSc, PGDipHons (UQ) (part-time)Vavrina A, BMedSci (50%)
Peptide SynthesisMcAndrew K, AssDipAppSci (UC)
Administrative AssistantMoore S
Finance and Research SupportFinance ManagerSawyer V
Senior Finance Offi cerSinnott T
Finance Offi cersCairns C (part-time)Cousins M (from October)Mimenza M (until September)Talbot M
General ServicesHeadElsbury S, BAppSc, GradDipMedLabTech
PurchasingSenior Purchasing Offi cersBerkeley S (until July)Hicks G (from August)
Purchasing Offi cersAllan N (from October)Hicks G (acting Senior Purchasing Offi cer until August)Lavender S (from July)Tracey E
Purchasing AssistantLavender S (until June)
StoresSenior StorepersonClements R (from August)
StorepersonAllan N (until October)Clements R (until July)Daniel-Marsh D (from March)
SecurityBarancewicz D (casual)Blinksell PCarter ICiuffetelli LLazarov Z (from September)Simpkin WWilliams F (casual)
CleanersBelling NBourke PBourke R (casual)Grant DHatton M (casual)Hayden C (casual)Kim J (from August)McVey SWhite NWilliams F (casual)Williams J
Information Technology & Communications Unit (ITCU)HeadCollis A, BIT, BE(Hons) (from November)Williams A, BSc, GradDipCompSci, BSc(Hons) (UNE) (until July)
Network ManagerZhang Q, BComputerSci (Beijing), MBA
ProgrammerCole P
MultimediaEdwards K, Phot CertFenning M, Phot Cert, AAIPPMacklin J, Phot Cert
Client Support Team LeaderHenderson S, Teach Cert (University of London)
School Services
66
School Services
Client SupportBelacic D, BIT, Voc Ed Cert I & II (Business Management) (until December)McCulloch AOverall M (May-August)Porter C (until February)Reed A BComm(Hons) (from February)Sime D (from September)
Human ResourcesHeadBrowning KO
HR Offi cersCornwell HHayden AM
HR Assistant Offi cersGrant N (on secondment from NCEPH March-May)Smith BA
Microscopy and Cytometry Resource Facility (MCRF)HeadGillespie CM
Microscopy UnitSenior Technical Offi cerMcCart RJ, BA (Melb), BSc (Hons) (UWA)
Laboratory TechnicianMoss DJ (until February)
Histology LaboratorySenior Technical Offi cerPrins AS, BAppSci (RMIT)
Flow Cytometry LaboratoryTechnical SpecialistOsborne GW, BSc, ADAB (QUT) (until June)
Senior Technical Offi cerGrüninger S
Technical ServicesHeadFriend R (until May)Coombes D (from May)
Deputy HeadEmans P (from August)
Technical Offi cersBest NCommons RCremer PEllison JHosking AJakubaszek RJordan TKelly DKeys BLang PPercival MRhall GRobertson ASymons C
Administrative AssistantMcGann J
ApprenticesBackhouse BGair LHancock B
Staf
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04
Publications
Publications authored by JCSMR researchers in 2004 included
peer reviewed journal articles, invited reviews and book
chapters.
The John Curtin School of Medical Research Annual Review 2004
68
Publ
icat
ions
200
4
Ada, G (2004) Medical graduates and scientifi c research in Australia:a personal refl ection. Internal Medicine Journal 34(3):141-143
Ada, G (2004) The immunology of vaccination. Vaccines Plotkin SA and Orenstein WA. Philadelphia, WB Saunders Co. pp31-45
Ada, G (2004) Approaches to viral vaccine development involving chemokine receptors and their ligands, with special reference to human immunodefi ciency virus 1. Chemokines in Viral Infections pp109-117
Altin, JG, van Broekhoven, CL and Parish, CR (2004) Targeting dendritic cells with antigen-containing liposomes: antitumour immunity. Expert Opinion on Biological Therapy 4(11):1735-1747
Anderson, WB, Board, PG and Anders, MW (2004) Glutathione Transferase Zeta-Catalyzed Bioactivation of Dichloroacetic Acid: Reaction of Glyoxylate with Amino Acid Nucleophiles. Chemical research in toxicology 17:650-662
Andrews, MC, Schyvens, CG, McKenzie, KUS, Zhang, Y and Whitworth, JA (2004) Nitric oxide donation lowers blood pressure in adrenocorticotrophic hormone-induced hypertensive rats. Clinical and Experimental Hypertension 26(6):499-509
Baharvand, H and Matthaei, KI (2004) Culture condition difference for establishment of new embryonic stem cell lines from the C57BL/6 and BALB/c mouse strains. In Vitro Cellular & Deveopmental Biology-Animal 40(3-4):76-81
Baharvand, H, Power, JM, Ozsarac, N and Matthaei, KI (2004) Differentiation of embryonic stem cells into functional neurons in vitro. Neuroscience Research Communications 35(2):130-138
Baker, RT (2004) Ubiquitin-specifi c proteases 4 and 15. In: Handbook of Proteolytic Enzymes 2nd Edition Eds: Barrett AJ, Rawlings ND and Woessner JF pp1232-1236
Bao, Y, Konesky, K, Park, YJ, Rosu, S, Dyer, PN, Rangasamy, D, Tremethick, DJ, Laybourn, PJ and Luger, K (2004) Nucleosomes containing the histone variant H2A.Bbd organize only 118 base pairs of DNA. EMBO Journal 1:1-11
Beard, NA, Laver, DR and Dulhunty, AF (2004) Calsequestrin and the calcium release channel of skeletal and cardiac muscle. Progress in Biophysics & Molecular Biology 85(1):33-69
JCSMR Publications
Beckett, EAH, Bayguinov, YR, Sanders, KM, Ward, SM and Hirst, GDS (2004) Properties of unitary potentials generated by intramuscular interstitial cells of Cajal in the murine and guinea-pig gastric fundus. Journal of Physiology 559(1):259-269
Belz, GT, Smith, CM, Eichner, D, Shortman, K, Karupiah, G, Carbone, FR and Heath, WK (2004) Cutting edge: Conventional CD8 alpha(+) dendritic cells are generally involved in priming CTL immunity to viruses. Journal of Immunology 172(4):1996-2000
Berntson, A, Smith, RG and Taylor, WR (2004) Transmission of single photon signals through a binary synapse in the mammalian retina. Visual Neuroscience 21(5):693-702
Bertram, EM, Dawicki, W and Watts, TH (2004) Role of T cell costimulation in anti-viral immunity. Seminars in Immunology 16(3):185-196
Berven, LA, Willard, FS and Crouch, MF (2004) Role of the p70(S6K) pathway in regulating the actin cytoskeleton and cell migration. Experimental Cell Research 296(2):183-195
Blanden, RV, Franklin, A and Steele, EJ (2004) The boundaries of the distribution of somatic hypermutation of rearranged immunoglobulin variable genes. Immunology and Cell Biology 82(2):205-208
Board, PG, Anders, MW and Blackburn, AC (2004) Catalystic Function and Expression of Glutathione Transerase Zeta. Drug Metabolism and Transport Lash LH, Humana Press Inc. pp85-107
Board, PG, Coggan, M, Watson, S, Gage, PW and Dulhunty, AF (2004) CLIC-2 modulates cardiac ryanodine receptor Ca(2+) release channels. The International Journal of Biochemistry & Cell Biology 36:1599-1612
Booth, HS, MacNamara, SE, Nielsen, OM and Wilson, SR (2004) An iterative approach to determining the length of the longest common subsequence of two strings. Methodology and Computing in Applied Probability 6(4):401-421
Booth, HS, Maindonald, JH, Wilson, SR and Gready, JE (2004) An effi cient Z-score algorithm for assessing sequence alignments. Journal of Computational Biology 11(4):616-625
69
Publications 2004JCSMR Publications
Burden, CJ, Pittelkow, YE and Wilson, SR (2004) Statistical analysis of adsorption models for oligonucleotide microarrays. Statistical Applications in Genetics and Molecular Biology 3(1):35
Butterfi eld, A, Vedagiri, V, Lang E, Lawrence C, Wakefi eld MJ, Isaev A and Huttley GA (2004) PyEvolve: a toolkit for statistical modelling of molecular evolution. BMC Bioinformatics 5:1
Casarotto, MG, Green, D, Pace, S, Young, J and Dulhunty, AF (2004) Activating the ryanodine receptor with dihydropyridine receptor 11-111 loop segments: size and charge do matter. Frontiers in Bioscience 9:2860-2872
Catanzariti, AM, Soboleva, TA, Jans, DA, Board, PG and Baker, RT (2004) An effi cient system for high-level expression and easy purifi cation of authentic recombinant proteins. Protein Science 13(5):1331-1339
Chaudhri, G, Panchanathan, V, Buller, RM, Van Den Eertwegh, AJ, Claassen, E, Zhou, J, De Chazal, R, Laman, JD and Karupiah, G (2004) Polarized type 1 cytokine response and cell-mediated immunity determine genetic resistance to mousepox. Proceedings of the National Academy of Sciences of the United States of America 101(24):9057-9062
Clark, IA, Alleva, LM, Mills, AC and Cowden, WB (2004) Pathogenesis of malaria and clinically similar conditions. Clinical Microbiology Reviews 17(3):509-539
Clark, K, Simson, L, Newcombe, N, Koskinen, AM, Mattes, J, Lee, NA, Lee, JJ, Dent, LA, Matthaei, KI and Foster, PS (2004) Eosinophil degranulation in the allergic lung of mice primarily occurs in the airway lumen. Journal of Leukocyte Biology 75:1001-1009
Cowan, AI and Stricker, C (2004) Functional connectivity in layer IV local circuits of rat somatosensory cortex. Journal of Neurophysiology 92(4):2137-2150
Cummins, PL, Bliznyuk, AA and Gready, JE (2004) Solvent Simulation. In: Computational Medicinal Chemistry and Drug Discovery Eds: Tollenaere, JP, Bultinck, P, de Winter, H and Langenaeker, W, Marcel Dekker, New York, pp259-294
Dale, CJ, De Rose, R, Stratov, I, Chea, S, Montefi ori, DC, Thomson, S, Ramshaw, IA, Coupar, BEH, Boyle, DB, Law, M and Kent, SJ (2004) Effi cacy of DNA and fowlpox virus priming/boosting vaccines for simian/human immunodefi ciency virus. Journal of Virology 78(24):13819-13828
Dale, CJ, De Rose, R, Wilson, KM, Croom, HA, Thomson, S, Coupar, BEH, Ramsay, A, Purcell, DFJ, Ffrench, R, Law, M, Emery, S, Cooper, DA, Ramshaw, IA, Boyle, DB and Kent, SJ (2004) Evaluation in macaques of HIV-1 DNA vaccines containing primate CpG motifs and fowlpoxvirus vaccines co-expressing IFN gamma or IL-12. Vaccine 23(2):188-197
Dawicki, W, Bertram, EM, Sharpe AH, Watts, TH (2004) 4-1BB and OX-40 act independently to facilitate robust CD8 and CD4 recall responses. Journal of Immunology 173(10): 5944-5951
De Armentia, ML and Sah, P (2004) Firing properties and connectivity of neurons in the rat lateral central nucleus of the amygdala. Journal of Neurophysiology 92(3):1258-1294
Doan, T, Herd, K, Ramshaw, I, Thomson, S and Tindle, R (2004) A polytope DNA vaccine elicits multiple effector and memory CTL responses and protects against human papillomavirus 16 E7-expressing tumour. Cancer Immunology Immunotherapy: eFirst
Dulhunty, AF, Cengia, L, Young, J, Pace, SM, Harvey, PJ, Lamb, GD, Chan, YN, Wimmer, N, Toth, I and Casarotto, MG (2004) Functional implications of modifying RyR-activating peptides for membrane permeability. British Journal of Pharmacology 1:1-12
Dulhunty, AF, Curtis, SM, Cengia, L, Sakowska, M and Casarotto, MG (2004) Peptide fragments of the dihydropyridine receptor can modulate cardiac ryanodine receptor channel activity and sarcoplasmic reticulum Ca2+ release. Biochemical Journal 379:161-172
Dulhunty, AF, Curtis, SM, Watson, S, Cengia, L and Casarotto, MG (2004) Multiple actions of imperatoxin a on ryanodine receptors - Interactions with the II-III loop A fragment. Journal of Biological Chemistry 279(12):11853-11862
Duraiswamy, J, Bharadwaj, M, Tellam, J, Connolly, G, Cooper, L, Moss, D, Thomson, S, Yotnda, P and Khanna, R (2004) Induction of therapeutic T-cell responses to subdominant tumor-associated viral oncogene after immunization with replication-incompetent polyepitope adenovirus vaccine. Cancer Research 64(4):1483-1489
70
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ions
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4
Dwyer, T, Ponsonby, AL, Stankovich, J, Blizzard, L and Easteal, S (2004) Measuring environmental factors can enhance the search for disease causing genes? Journal of Epidemiology and Community Health 58(7):613-5
Everitt, AB, Luu, T, Cromer, B, Tierney, ML, Birnir, B, Olsen, RW and Gage, PW (2004) Conductance of recombinant GABA(A) channels is increased in cells co-expressing GABA(A) receptor-associated protein. Journal of Biological Chemistry 279(21):21701-21706
Ewart, GD, Nasr, N, Naif, H, Cox, GB, Cunningham, AL and Gage, PW (2004) Potential New Anti-Human Immunodefi ciency Virus Type 1 Compounds Depress Replication in Cultured Human Macrophages. Antimicrobial Agents and Chemotherapy 48(6):2325-2330
Faber, ESL and Sah, P (2004) Opioids inhibit lateral amygdala pyramidal neurons by enhancing a dendritic potassium current. Journal of Neuroscience 24(12):3031-3039
Fan, J, Rangasamy, D, Luger, K and Tremethick, DJ (2004) H2A.Z alters the nucleosome surface to promote HP1alpha- mediated chromatin fi bre folding. Molecular Cell 16(4):655-661
Forbes, E, Murase, T, Yang, M, Matthaei, KI, Lee, JJ, Lee, NA, Foster, PS and Hogan, SP (2004) Immunopathogenesis of experimental ulcerative colitis is mediated by eosinophil peroxidase. Journal of Immunology 172(9):5664-5675
Forbes, E, Smart, VE, D’Aprile, A, Henry, P, Yang, M, Matthaei, KI, Rothenberg, ME, Foster, PS and Hogan, SP (2004) T helper-2 immunity regulates bronchial hyperresponsiveness in eosinophil-associated gastrointestinal disease in mice. Gastroenterology 127(1):105-118
Franklin, A and Blanden, RV (2004) On the molecular mechanism of somatic hypermutation of rearranged immunoglobulin genes. Immunology and Cell Biology 82(6):557-567
Franklin, A, Milburn, PJ, Blanden, RV and Steele, EJ (2004) Human DNA polymerase-eta, an A-T mutator in somatic hypermutation of rearranged immunoglobulin genes, is a reverse transcriptase. Immunology and Cell Biology 82(2):219-225
JCSMR Publications
Friedburg, C, Allen, CP, Mason, PJ and Lamb, TD (2004) Contribution of cone photoreceptors and post-receptoral mechanisms to the human photopic electroretinogram. Journal of Physiology 556(3):819-834
Fuhrmann, G, Cowan, AI, Segev, I, Tsodyks, MV and Stricker, C (2004) Multiple mechanisms govern synaptic dynamics at neocortical synapses. Journal of Physiology 557:415-438
Fulkerson, PC, Zimmermann, N, Brandt, EB, Muntel, EE, Doepker, MP, Kavanaugh, JL, Mishra, A, Witte, DP, Zhang, HW, Farber, JM, Yang, M, Foster, PS and Rothenberg, ME (2004) Negative regulation of eosinophil recruitment to the lung by the chemokine monokine induced by IFN-gamma (Mig, CXCL9) Proceedings of the National Academy of Sciences of the United States of America 101(7):1987-1992
Gallant, EM, Hart, J, Eager, K, Curtis, S and Dulhunty, AF (2004) Caffeine sensitivity of native RyR channels from normal and malignant hyperthermic pigs:effects of a DHPR II-III loop peptide. American Journal of Physiology-Cell Physiology 286(4):C821-C830
Goto, K, Fujii, K, Kansui, Y and Iida, M (2004) Changes in endothelium-derived hyperpolarizing factor in hypertension and ageing: Response to chronic treatment with renin-angiotensin system inhibitors. Clinical and Experimental Pharmacology and Physiology 31(9):650-655
Goto, K, Rummery, NM, Grayson, TH and Hill, CE (2004) Attenuation of conducted vasodilation in rat mesenteric arteries during hypertension: Role of inwardly rectifying potassium channels. Journal of Physiology 561(1):215-231
Grayson, TH, Haddock, RE, Murray, TP, Wojcikiewicz, RJH and Hill, CE (2004) Inositol 1,4,5-trisphophate receptor subtypes are differentially distributed between the smooth muscle and endothelial layers of rat arteries. Cell Calcium 36(6):447-458
Grumont, R, Lock, P, Mollinari, M, Shannon, MF, Moore, A and Gerondakis, S (2004) The mitogen-induced increase in T cell size involves PKC and NFAT activation of Rel/NF-kappa B-dependent c-myc expression. Immunity 21(1):19-30
71
Publications 2004
Gustiananda, M, Liggins, JR, Cummins, PL and Gready, JE (2004) Conformation of prion protein repeat peptides probed by FRET measurements and molecular dynamics simulations. Biophysical Journal 86(4):2467-2483
Hamilton, NHR, Mahalingam, S, Banyer, JL, Ramshaw, IA and Thomson, SA (2004) A recombinant vaccinia virus encoding the interferon-inducible T-cell alpha chemoattractant is attenuated in vivo. Scandinavian Journal of Immunology 59(3):246-254
Hammarstrom, AK and Gage, PW (2004) Methods to study oxygen sensing sodium channels. Methods in Enzymology 381:275-290
Han, NLR, Clements, JD and Lynch, JW (2004) Comparison of taurine- and glycine-induced conformational changes in the M2-M3 domain of the glycine receptor. Journal of Biological Chemistry 279(19):19559-19565
Henderson, A, Holloway, A, Reeves, R and Tremethick, DJ (2004) Recruitment of SWI/SNF to the human immunodefi ciency virus type 1 promoter. Molecular and Cellular Biology 24(1):389-397
Henness, S, Davey, MW, Harvie, RM, Banyer, J, Wasinger, V, Corthals, G and Davey, RA (2004) Changes in gene expression associated with stable drug and radiation resistance in small cell lung cancer cells are similar to those caused by a single X-ray dose. Radiation Research 161(5):495-503
Hennig, GW, Hirst, GDS, Park, KJ, Smith, CB, Sanders, KM, Ward, SM and Smith, TK (2004) Propagation of pacemaker activity in the guinea-pig antrum. Journal of Physiology 556(2):585-599
Hill, CE (2004) Development of the Autonomic Nervous System. In: Primer on the Autonomic Nervous System. Eds: Robertson D, Low P and Burnstock G, Academic Press
Hirst, GDS, Bywater, RAR, Teramoto, N and Edwards, FR (2004) An analysis of inhibitory junction potentials in the guinea-pig proximal colon. Journal of Physiology 558(3):841-855
Hirst, GDS and Edwards, FR (2004) Role of interstitial cells of Cajal in the control of gastric motility. Journal of Pharmacological Sciences 96(1):1-10
JCSMR Publications
Hogan, SP, Rothenberg, ME, Forbes, E, Smart, VE, Matthaei, KI and Foster, PS (2004) Chemokines in Eosinophil-associated Gastrointestinal Disorders. Current Allergy Asthma Rep 4(1):74-82
Huttley, GA (2004) Modeling the Impact of DNA Methylation on the Evolution of BRCA1 in Mammals. Molecular Biology and Evolution 21(9):1760-1768
Jones, AL, Hulett, MD, Altin, JG, Hogg, P, Parish, CR (2004) Plasminogen is tethered with high affi nity to the cell surface by the plasma protein, histidine-rich glycoprotein. Journal of Biological Chemistry 279(37):38267-38276
Jones, AL, Hulett, MD and Parish, CR (2004) Histidine-Rich Glycoprotein Binds to Cell Surface Heparan Sulfate via its Amino-Terminal Domain Following Zn2+ Chelation. Journal of Biological Chemistry 279(29):30114-30122
Jorm, AF, Butterworth, P, Anstey, KJ, Christensen, H, Easteal, S, Maller, J, Mather, KA, Turakulov, RI, Wen, W and Sachdev, P (2004) Memory complaints in a community sample aged 60-64 years: Associations with cognitive functioning, psychiatric symptoms, medical conditions, APOE genotype, hippocampus and amygdala volumes, and white-matter hyperintensities. Psychological Medicine 34(8):1495-1506
Jorm, AF, Christensen, H, Rodgers, B, Jacomb, PA and Easteal, S (2004) Association of adverse childhood experiences, age of menarche, and adult reproductive behavior: Does the androgen receptor gene play a role? American Journal of Medical Genetics Part B-Neuropsychiatric Genetics 125B(1):105-111
Kampa, BM, Clements, J, Jonas, P and Stuart, GJ (2004) Kinetics of Mg2+ unblock of NMDA receptors: implications for spike-timing dependent synaptic plasticity. Journal of Physiology 556(2):337-345
Katsifi s, A, Barlin, G, Mattner, F and Dikic, B (2004) Synthesis of [I-123] iodine labelled imidazo[1,2-b] pyridazines as potential probes for the study of peripheral benzodiazepine receptors using SPECT. Radiochimica ACTA 92(4-6):305-309
Kay, AB, Phipps, S and Robinson, DS (2004) A role for eosinophils in airway remodelling in asthma. Trends in Immunology 25(9):477-482
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Khachigian, LM and Parish, CR (2004) Phosphomannopentaose sulfate (PI-88): Heparan sulfate mimetic with clinical potential in multiple vascular pathologies. Cardiovascular Drug Reviews 22(1):1-6
Kiyosawa, H, Kawashima, T, Silva, D, Petrovsky, N, Hasegawa, Y, Sakai, K and Hayashizaki, Y (2004) Systematic genome-wide approach to positional candidate cloning for identifi cation of novel human disease genes. Internal Medicine Journal 34(3):79-90
Kloda, A, Clements, JD, Lewis, RJ and Adams, DJ (2004) Adenosine triphosphate acts as both a competitive antagonist and a positive allosteric modulator at recombinant N-methyl-D-aspartate receptors. Molecular Pharmacology 65(6):1386-1396
Kuchel, PW, Bubb, WA, Ramadan, S, Chapman, BE, Philp, DJ, Coen, M, Gready, JE, Harvey, PJ, McLean, AJ and Hook, J (2004) 31P MAS-NMR of human erythrocytes; independence of cell volume on spin rate. Magnetic Resonance in Medicine 52:663-668
Kumar, RK, Herbert, C and Foster, PS (2004) Expression of growth factors by airway epithelial cells in a model of chronic asthma: regulation and relationship to subepithelial fi brosis. Clinical and Experimental Allergy 34(4):567-575
Kumar, RK, Herbert, C, Webb, DC, Li, L and Foster, PS (2004) Effects of anticytokine therapy in a mouse model of chronic asthma. American Journal of Respiratory and Critical Care Medicine 170(10):1043-1048
Kunzelmann, K, Konig, J, Sun, J, Markovich, D, King, NJ, Karupiah, G, Young, JA and Cook, DI (2004) Acute effects of parainfl uenza virus on epithelial electrolyte transport. Journal of Biological Chemistry 279(47):48760-48766
Lamb, TD and Pugh, EN (2004) Dark adaptation and the retinoid cycle of vision. Progress in Retinal and Eye Research 23:307-380
Leao, RN, Berntson, A, Forsythe, ID and Walmsley, B (2004) Reduced low-voltage activated K+ conductances and enhanced central excitability in a congenitally deaf (dn/dn) mouse. Journal of Physiology 559(1):25-33
Leao, RN and Burne, JA (2004) Continuous wavelet transform in the evaluation of stretch refl ex responses from surface EMG. Journal of Neuroscience Methods 133(1-2):115-125
JCSMR Publications
Leao, RN, Oleskevich, S, Sun, H, Bautista, M, Fyffe, REW and Walmsley, B (2004) Differences in glycinergic mIPSCs in the auditory brain stem of normal and congenitally deaf neonatal mice. Journal of Neurophysiology 91(2):1006-1012
Leck, KJ, Bartlett, SE, Smith, MT, Megirian, D, Holgate, J, Powell, KL, Matthaei, KI and Hendry, IA (2004) Deletion of guanine nucleotide binding protein alpha(z) subunit in mice induces a gene dose dependent tolerance to morphine. Neuropharmacology 46(6):836-846
Lee, E, Hall, RA and Lobigs, M (2004) Common E protein determinants for attenuation of glycosaminoglycan-binding variants of Japanese encephalitis and West Nile viruses. Journal of Virology 78(15):8271-8280
Leigh, R, Ellis, R, Wattlie, JN, Hirota, JA, Matthaei, KI, Foster, PS, O’Byrne, PM and Inman, MD (2004) Type 2 cytokines in the pathogenesis of sustained airway dysfunction and airway remodeling in mice. American Journal of Respiratory and Critical Care Medicine 169(7):860-867
Levidiotis, V, Freeman, C, Punler, M, Martinello, P, Creese, B, Ferro, V, van der Vlag, J, Berden, JHM, Parish, CR and Power, DA (2004) A Synthetic Heparanase Inhibitor Reduces Proteinuria in Passive Heymann Nephritis. Journal of the American Society of Nephrology 15(11):2882-2892
Levidiotis, V, Freeman, C, Tikellis, C, Cooper, ME and Power, DA (2004) Heparanase is involved in the pathogenesis of proteinuria as a result of glomerulonephritis. Journal of the American Society of Nephrology 15(1):68-78
Lim, CEL, Matthaei, KI, Blackburn, AC, Davis, RP, Dahlstrom, JE, Koina, ME, Anders, MW and Board, PG (2004) Mice defi cient in glutathione transferase zeta/maleylacetoacetate isomerase exhibit a range of pathological changes and elevated expression of Alpha, Mu, and Pi class glutathione transferases. American Journal of Pathology 165(2):679-693
Liston, A, Gray, DHD, Lesage, S, Fletcher, AL, Wilson, J, Webster, KE, Scott, HS, Boyd, RL, Peltonen, L and Goodnow, CC (2004) Gene dosage-limiting role of Aire in thymic expression, clonal deletion and organ-specifi c autoimmunity. Journal of Experimental Medicine 200(8):1015-1026
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Liston, A, Lesage, S, Gray, DHD, O’Reilly, LA, Strasser, A, Fahrer, AM, Boyd, RL, Wilson, J, Baxter, AG, Gallo, EM, Crabtree, GR, Peng, K, Wilson, SR and Goodnow, CC (2004) Generalised resistance to thymic deletion in the NOD mouse: a polygenic trait characterized by defective induction of Bimí. Immunity 21(6):817-830
Lobigs, M and Lee, E (2004) Ineffi cient signalase cleavage promotes effi cient nucleocapsid incorporation into budding fl avivirus membranes. Journal of Virology 78(1):178-186
Lobigs, M, Müllbacher, A and Lee, E (2004) Evidence that a mechanism for effi cient fl avivirus budding upregulates MHC class I. Immunology and Cell Biology 82(2):184-188
Mahroo, OAR and Lamb, TD (2004) Recovery of the human photopic electroretinogram after bleaching exposures: estimation of pigment regeneration kinetics. Journal of Physiology 554(2):417-437
Maindonald, J and Richardson, AM (2004) This Passionate Study - A Dialogue with Florence Nightingale. Journal of Statistics Education 12(1):1-11
Matthaei KI (2004) Caveats of Gene Targeted and Transgenic Mice. In: Handbook of Stem Cells, Volume 1: Embryonic Stem Cells Eds: Lanza R et al, Elsevier Academic Press, pp589-598
McGinty, D, Metes, A, Alam, Md N, Megirian, D, Stewart D, and Szymusiak, R (2004) Preoptic Hypothalamic Warming Suppresses Laryngeal Dilator Activity during Sleep. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 286:R1129-R1137
McLean, AJ and Le Couteur, DG (2004) Aging biology and geriatric clinical pharmacology. Pharmacological Reviews 56(2):163-184
Miller DS, Bertram, EM, Scougall, CA, Kotlarski, I, Jilbert AR (2004) Studying host immune responses against duck hepatitis B virus infection. Methods in Molecular Medicine 96: 3-25
Müllbacher, A, Regner, M, Wang, Y, Lee, E, Lobigs, M, Simon, M (2004) Can we really learn from model pathogens? Trends in Immunology 25(10):524-528
Müllbacher, A and Blanden, RV (2004) T-Cell-Mediated Control of Poxvirus Infection in Mice. In: Viruses and Apoptosis. Ed: Alonso C. Berlin-Heidelberg, Springer-Verlag. pp39-55
JCSMR Publications
Murphy, JM, Ford, SC, Olsen, JE, Gustin, SE, Jeffrey, PD, Ollis, DL and Young, IG (2004) Interleukin-3 Binding to the Murine beta IL-3 and Human beta c Receptors Involves Functional Epitopes Formed by Domains 1 and 4 of Different Protein Chains. Journal of Biological Chemistry 279(25):26500-26508
Nagashima, T, Matsuda, H, Silva, DG, Petrovsky, N, Konagaya, A, Schonbach, C, RG Group and GSL Members (2004) FREP: a database of functional repeats in mouse cDNAs. Nucleic Acids Research 32:D471-D475
Ng, CH, Schweitzer, I, Norman, T and Easteal, S (2004) The emerging role of pharmacogenetics: implications for clinical psychiatry. Australian and New Zealand Journal of Psychiatry. 38(7):483-489
Nyberg, K, Bergstrom, T, Freeman, C, Parish, CR, Ferro, V and Trybala, E (2004) The low molecular weight heparan sulfate-mimetic, PI-88, inhibits cell-to-cell spread of herpes simplex virus. Antiviral Research 63(1):15-24
Oleskevich, S, Youssoufi an, M, and Walmsley, B (2004) Presynaptic plasticity at two giant auditory synapses in normal and deaf mice. Journal of Physiology 560(3):709-719
Pardo, J, Basque, A, Brehm, R, Wallich, R, Naval, J, Müllbacher, A, Anel, A and Simon, MM (2004) Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis. The Journal of Cell Biology 167(3):457-468
Parish, CR (2004) Innate immune mechanisms: non-self recognition. In: Encyclopedia of Life Sciences London, Macmillan
Park, Y-J, Dyer, PN, Tremethick, DJ and Luger, K (2004) A new FRET approach demonstrates that the histone variant H2AZ stabilizes the histone octamer within the nucleosome. Journal of Biological Chemistry 279(23):24274-82
Peters, KE and Cavanaugh, JA (2004) Genetic Disorders in Gastroenterology and Hepathology. Card15 and Crohn’s disease. Journal of Gastroenterology and Hepatology 19(7):830
Premkumar, A, Ewart, GD, Cox, GB and Gage, PW (2004) An amino-acid substitution in the infl uenza-B NB protein affects ion-channel gating. Journal of Membrane Biology 197(3):135-143
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Premkumar, A, Wilson, L, Ewart, GD and Gage, PW (2004) Cation-selective ion channels formed by p7 of hepatitis C virus are blocked by hexamethylene amiloride. FEBS Letters 557(1-3):99-103
Premzl, M, Gready, JE, Jermiin, LS, Simonic, T and Graves, JAM (2004) Evolution of vertebrate genes related to Prion and Shadoo proteins - clues from comparative genomic analysis. Molecular Biololgy and Evolution 21(12):2210-2231
Rangasamy, D, Greaves, I and Tremethick, DJ (2004) RNA interference demonstrates a novel role for H2A.Z in chromosome segregation. Nature Structural and Molecular Biology 11(7):650-655
Regner, M and Müllbacher, A (2004) Granzymes in cytolytic lymphocytes - to kill a killer? Immunology and Cell Biology 82(2):161-169
Ricci, G, Turella, P, De Maria, F, Antonini, G, Nardocci, L, Board, PG, Parker, MW, Carbonelli, MG, Federici, G and Caccuri, AM (2004) Binding and kinetic mechanisms of the zeta class glutathione transferase. Journal of Biological Chemistry 279(32):33336-33342
Richerson, GB and Bekkers, JM (2004) Learning to take a deep breath - with BDNF. Nature Medicine 10(1):25-26
Ridgway, P, Brown, KD, Rangasamy, D, Svensson, U, Tremethick, DJ (2004) Unique residues on the H2A.Z containing nucleosome surface are important for Xenopus laevis development. Journal of Biological Chemistry 279(42):43815-20
Ridgway, P, Rangasamy, D, Berven, L, Svensson, U and Tremethick, DJ (2004) Analysis of histone variant H2A.Z localization and expression during early development. Chromatin and Chromatin Remodeling Enzymes, Pt A. San Diego, Academic Press Inc. 375:239-252
Robinson, A, Huttley, GA, Booth, HS and Board, PG (2004) Modelling and bioinformatics studies of the human Kappa-class glutathione transferase predict a novel third glutathione transferase family with similarity to prokaryotic 2-hydroxychromene-2-carboxylate isomerases. Biochemical Journal 379:541-552
JCSMR Publications
Rode, M, Balkow, S, Sobek, V, Brehm, R, Martin, P, Kersten, A, Dumrese, T, Stehle, T, Müllbacher, A, Wallich, R and Simon, MM (2004) Perforin and Fas act together in the induction of apoptosis, and both are critical in the clearance of lymphocytic choriomeningitis virus infection. Journal of Virology 78(22):12395-12405
Rolph, MS, Mahalingam, S and Cowden, WB (2004) Nonspecifi c antiviral immunity by formalin-fi xed Coxiella burnetii is enhanced in the absence of nitric oxide. Virology 326(1):1-5
Rummery, NM and Hill, CE (2004) Vascular Gap Junctions and Implications for Hypertension. Clinical and Experimental Pharmacology and Physiology 31(10):659-667
Sandow, SL (2004) Factors, fi ction and endothelium-derived hyperpolarizing factor. Clinical and Experimental Pharmacology and Physiology 31(9):563-570
Sandow, SL, Goto, K, Rummery, NM and Hill, CE (2004) Developmental changes in myoendothelial gap junction mediated vasodilator activity in the rat saphenous artery. Journal of Physiology 556(3):875-886
Schyvens, CG, Cowden, WB, Zhang, Y, McKenzie, KUS and Whitworth, JA (2004) Hemodynamic effects of the nitric oxide donor DETA/NO in mice. Clinical and Experimental Hypertension 26(6):525-535
Selvey, S, Haupt, LM, Thompson, EW, Matthaei, KI, Irving, MG and Griffi ths, LR (2004) Stimulation of MMP-II (stromelysin-3) expression in mouse fi broblasts by cytokines, collagen and co-culture with human breast cancer cell lines . BMC Cancer 4:40
Serreze, DV, Holl, TM, Marron, MP, Graser, RT, Johnson, EA, Choisy-Rossi, C, Slattery, RM, Lieberman, SM and DiLorenzo, TP (2004) MHC class II molecules play a role in the selection of autoreactive class I-restricted CD8 T cells that are essential contributors to type 1 diabetes development in nonobese diabetic mice. Journal of Immunology 172(2):871-879
Silva, D, Schoenbach, C, Brusic, V, Socha, L, Nagashima, T and Petrovsky, N (2004) Identifi cation of pathologs (disease-related genes) from the RIKEN mouse cDNA dataset using human curation plus FACTS, a new biological information extraction system. BMC Genomics 5(28):1-14
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Soboleva, TA and Baker, RT (2004) Deubiquitinating Enzymes:Their functions and substrate specifi city. Current Protein and Peptide Science 5(3):191-200
Solomon, MF, Kuziel, WA and Simeonovic, CJ (2004) The contribution of chemokines and chemokine receptors to the rejection of fetal proislet allografts. Cell Transplantation 13(5):503-514
Song, ZM, Abou-Zeid, O and Fang, YY (2004) Alpha 2A adrenoceptors regulate phosphorylation of microtubule-associated protein-2 in cultured cortical neurons. Neuroscience 123(2):405-418
Steele, EJ, Franklin, A and Blanden, RV (2004) Genesis of the strand-biased signature in somatic hypermutation of rearranged immunoglobulin variable genes. Immunology and Cell Biology 82(2):209-218
Strachan, J, Chang, LY, Wakefi eld, MJ, Graves, JA and Deeb, SS (2004) Cone visual pigments of the Australian marsupials, the stripe-faced and fat-tailed dunnarts: sequence and inferred spectral properties. Visual Neuroscience 21(3):223-9
Tetlow, N and Board, PG (2004) Functional polymorphism of human glutathione transferase A2. Pharmacogenetics 14(2):111-116
Tetlow, N, Coggan, M, Casarotto, MG and Board, PG (2004) Functional polymorphism of human glutathione transferase A3: effects on xenobiotic metabolism and steroid biosynthesis. Pharmacogenetics 14(10):657-663
Tetlow, N, Robinson, A, Mantle, T, and Board, PG (2004) Polymorphism of human mu class glutathione transferases. Pharmacogenetics 14(6):359-68
Tierney, ML, Osborn, KE, Milburn, PJ, Stowell, MHB and Howitt, SM (2004) Phylogenetic conservation of disulfi de-linked, dimeric acetylcholine receptor pentamers in southern ocean electric rays. Journal of Experimental Biology 207(20):3581-3590
Torpy, DJ, Bachmann, AW, Gartside, M, Grice, JE, Harris, JM, Clifton, P, Easteal, S, Jackson, RV and Whitworth, JA (2004) Association between chronic fatigue syndrome and the corticosteroid-binding globulin gene ALA SER224 polymorphism. Endocrine Research 30(3):417-429
JCSMR Publications
Tran, HA, Silva, D and Petrovsky, N (2004) Potential pitfalls of using HbA1c as the sole measure of glycaemic control. Clinical Diabetes 22(3):141-43
Turakulov, R, Jorm, AF, Jacomb, PA, Tan, X and Easteal, S (2004) Association of dopamine-p-hydroxylase and androgen receptor gene polymorphisms with Eysenck’s P and other personality traits. Personality and Indiviual Differences 37(1):191-202
van Broekhoven, CL, Parish, CR, Demangel, C, Britton, WJ and Altin, JG (2004) Targeting dendritic cells with antigen-containing liposomes: A highly effective procedure for induction of antitumor immunity and for tumor immunotherapy. Cancer Research 64(12):4357-4365
Vinuesa, CG and Goodnow, CC (2004) Illuminating Autoimmune Regulators through Controlled Variation of the Mouse Genome Sequence. Immunity 20(6):669-679
Wang, Y, Lobigs, M, Lee, E and Müllbacher, A (2004) Exocytosis and Fas mediated cytolytic mechanisms exert protection from West Nile virus induced encephalitis in mice. Immunology and Cell Biology 82(2):170-173
Ward, SM, Sanders, KM and Hirst, GDS (2004) Role of interstitial cells of Cajal in neural control of gastrointestinal smooth muscles. Neurogastroenterology and Motility 16:112-117
Watts, TH and Bertram, EM (2004) Introduction: Anti-Viral Immunity. Seminars in Immunology 16(3):145-146
Webb, DC, Matthaei, KI, Cai, YP, McKenzie, ANJ and Foster, PS (2004) Polymorphisms in IL-4R alpha correlate with airways hyperreactivity, eosinophilia, and Ym protein expression in allergic IL-13(-/-) mice. Journal of Immunology 172(2):1092-1098
Weible, MW and Hendry, IA (2004) What is the importance of multivesicular bodies in retrograde axonal transport in vivo? Journal of Neurobiology 58(2):230-243
Weible, MW, Ozsarac, N, Grimes, ML and Hendry, IA (2004) Comparison of nerve terminal events in vivo effecting retrograde transport of vesicles containing neurotrophins or synaptic vesicle components. Journal of Neuroscience Research 75(6):771-781
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Wertz, IE, O’Rourke, KM, Zhou, H, Eby, M, Aravind, L, Seshagiri, S, Wu, P, Wiesmann, C, Baker, R, Boone, DL, Ma, A, Koonin, EV and Dixit, VM (2004) De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling. Nature 430(7000):694-699
Whitbread, AK, Mellick, GD, Silburn, PA, Le Couteur, DG and Board, PG (2004) Glutathione transferase Omega class polymorphisms in Parkinson disease. Neurology 62:1910-1911
Whitworth, JA (2004) Hypertensive Treatment in Pregnant Women. 3rd Asian-Pacifi c Congress of Hypertension, Singapore, Medimond, Italy, 31-35
Whitworth, JA (2004) Anti-hypertensive drug treatment in diabetes and renal disease. 3rd Asian-Pacifi c Congress of Hypertension, Singapore, Medimond, Italy, 37-41
Whitworth, JA (2004) Relationship between white blood cell count and incident hypertension. American Journal of Hypertension 17(9):861-862
Whitworth, JA (2004) The need for new drugs: a response (editorial) Australian Prescriber 27(6):137-138
Whitworth, JA and Chalmers, J (2004) World Health Organisation-International Society of Hypertension (WHO/ISH) Hypertension Guidelines. Clinical and Experimental Hypertension 26(7 and 8):747-752
Whitworth, JA, Mangos, GJ and Kelly, JJ (2004) Hypertension in Cushing’s syndrome. Secondary Hypertension:Clinical Presentation, Diagnosis, and Treatment Ed: George A Mansoor Totowa, Humana Press Inc, New Jersey pp195-220
Whitworth, JA, Phillips, M and Jack, J (2004) The Wellcome Trust in Australasia:return on investment. Internal Medicine Journal 34(4):211-214
Wilson, L, McKinlay, C, Gage, PW and Ewart, GD (2004) SARS coronavirus E protein forms cation-selective ion channels. Virology 330(1):322-331
Xie, W, McCahon, P, Jakobsen, K and Parish, C (2004) Evaluation of the ability of digital infrared imaging to detect vascular changes in experimental animal tumours. International Journal of Cancer 108(5):790-794
JCSMR Publications
Xu, D, Regner, M, Smith, D, Ruby, J, Johnstone, R and Müllbacher, A (2004) The multidrug resistance gene mdr1a infl uences resistance to ectromelia virus infection by mechanisms other than conventional immunity. Immunology and Cell Biology 82:462-470
Xue, J, Milburn, PJ, Hanna, BT, Graham, ME, Rostas, JAP and Robinson, PJ (2004) Phosphorylation of septin 3 on Ser-91 by cGMP-dependent protein kinase-I in nerve terminals. Biochemical Journal 381:753-760 Part 3
Zelensky, AN and Gready, JE (2004) C-type-lectin-like domains in Fugu rubripes. BMC Genomics 5(1):51
Zhang, Y, Andrews, MC, Schyvens, CG, McKenzie, KUS and Whitworth, JA (2004) Adrenocorticotropic hormone, blood pressure, and serum erythropoietin concentrations in the rat. American Journal of Hypertension 17(5):457-461
Zhang, Y, Croft, KD, Mori, TA, Schyvens, CG, McKenzie, KUS and Whitworth, JA (2004) The antioxidant tempol prevents and partially reverses dexamethasone-induced hypertension in the rat. American Journal of Hypertension 17(3):260-265
Zhang, Y, Oliver, JR and Horowitz, JD (2004) The role of endothelin in mediating ischemia/hypoxia-induced atrial natriuretic peptide release. Journal of Cardiovascular Pharmacology 43(2):227-233
Zhang, Y, Pang, T, Earl, J, Schyvens, CG, McKenzie, KUS and Whitworth, JA (2004) Role of tetrahydrobiopterin in adrenocorticotropic hormone-induced hypertension in the rat. Clinical and Experimental Hypertension 26(3):231-241
Zhaol, ZQ, Lacey, G, Hendry, IA and Morton, CR (2004) Substance P release in the cat spinal cord upon afferent C-fi bre stimulation is not attenuated by clonidine at analgesic doses. Neuroscience Letters 361(1-3):216-219
Zinkernagel, RM and Doherty, PC (2004) Immunological surveillance against altered self components by sensitised T lymphocytes in lymphocytic choriomeningitis. The Journal of Immunology 173(5):2899-2900
Throughout 2004 we have continued to work towards the
goal of establishing contact with all past staff and students of
the School. We publish an updated version of our newsletter,
CurtinCall, which is now sent to over 1500 alumni and friends
of the School.
We are also actively strengthening contact with our local
community through our Public Affairs Officer, Madeleine
Nicol, who speaks to special interest groups throughout the
region about research programmes within the JCSMR, and the
importance of medical research.
Contact with our Community
The John Curtin School of Medical Research Annual Review 2004
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n Workshop WakeOur fi rst major event this year was the Workshop Wake in February. The Workshop has been in place for 50 years,
and many technical specialists have worked there during that time. Through the dedication and perseverance
of Mrs Lyn Crocker Bowman, herself an ex-Workshop staff member, we were able to track down nearly 80
former JCSMR Workshop staff. Many of them were able to join over 300 current staff and students at a wake to
celebrate ‘Half a century of excellence’ of the workshop prior to its demolition to make way for the new JCSMR
Building.
n VisitsDuring the early part of 2004, we enjoyed visits from many different groups, including a large group of visiting
Chinese academics, Better Hearing Australia, 128 National Youth Science Forum students, and representatives
of TADACT (Technical Aid to the Disabled, ACT Branch). We also hosted an ASMR Medical Research Week careers
seminar, and a Morning Tea to celebrate the contributions of long term donors to the Heart Foundation in the
ACT region.
n Ground Breaking CeremonyIn May, a Ground Breaking Ceremony was held to mark the offi cial launch of an exciting new project for The
Australian National University, Stage 1 of the new John Curtin School of Medical Research Building. Professor
Judith Whitworth welcomed guests, and in doing so paid tribute to those who had played a role in the project:
the Vice-Chancellor of The ANU, Professor Ian Chubb, The ANU Finance Committee, The ACT Government, the
Federal Government, JCSMR staff and students, architects Lyons and project managers John Hindmarsh. Emeritus
Professor Frank Fenner and new PhD student Julia Ellyard turned the fi rst sod on the project.
n Open DayOpen Day in August was an outstanding success, with many members of our local community joining school
students from Canberra and the region, as well as some from as far afi eld as Darwin, touring JCSMR laboratories
and facilities. Almost 600 visitors came through the School on Open Day, speaking with scientists from 14
research programmes about their work in such fi elds as cancer, diabetes, gene targeting, vision, asthma and
allergy, high blood pressure and hearing.
n Thank You Day CardIn October, we held a breakfast to celebrate Thank You Day. Research Australia’s Thank You Day initiative gives
the community an opportunity to say Thank You to medical researchers for the work they do. The Thank You
Day theme for 2004 was “Sporting Heroes thank Research Heroes”. Canberra sporting identities Lucille Bailie and
Owen Finigan signed a huge card in the JCSMR foyer. The card travelled around Australia as part of the project,
and was signed by elite athletes and medical researchers at breakfasts held in research facilities all over Australia.
“Thank you” Lucille and Owen, for your willingness to participate in the Canberra celebration!
Contact with our Community
National Youth Science Forum students “meet” Howard Florey in January
Professor Frank Fenner and PhD student Julia Ellyard turn the fi rst sod on the new JCSMR building
79
Comm
unity Contact
n CIT BallEach year, the Canberra Institute of Technology holds a Ball to raise funds for a
local Canberra organisation. This year, CIT chose to support the diabetes research
programme headed by Dr Charmaine Simeonovic in the JCSMR. At a ceremony in
November, Jackie Martin, Director of Communication and Marketing, CIT, presented
a cheque to Professor Judith Whitworth to support the research carried out by Dr
Simeonovic and her team. We are extremely grateful to the CIT staff who worked so
hard to ensure the success of the Ball, as evidenced by the amount of money raised
for diabetes research. Both Jackie Martin and Professor Whitworth spoke of the
importance of forging and continuing to strengthen ties between our two Canberra
institutions.
n Town and GownFor the past 3 years, the JCSMR has hosted annual Town and Gown drinks in the beautiful gardens of University
House. The Town and Gown event is a forum to promote informal exchange of ideas between representatives of
government, business and research communities in an extremely pleasant social setting.
n Happy Birthday Professor FennerAll members of the JCSMR were happy to join in wishing our own Australian Living Legend, Emeritus Professor
Frank Fenner, a very Happy 90th Birthday in December. In order to commemorate this wonderful occasion, JCSMR
staff and students sponsored a rose in Frank’s name in the newly refurbished Rose Gardens at Old Parliament
House in Canberra.
The communication of our research and our research needs to members of the general public is facilitated
through our Public Affairs Offi cer. Student and community groups in the ACT and surrounding region
regularly request speaker visits from within our School, which we are happy to arrange. In addition to visits
from our Public Affairs Offi cer, researchers from the School have addressed Better Hearing Australia, the
ACT Parkinson’s Awareness group, University of the 3rd Age meetings, and numerous Probus, Lions and
Rotary Club meetings. If you are interested in arranging a speaker for your community group or club, or
would like to book a tour of the JCSMR, please contact our Public Affairs Offi cer.
Contact DetailsDr Madeleine Nicol T: 02 6125 2577 E: [email protected]
Contact with our Community
Members of Better Hearing Australia spent the afternoon with Professor Bruce Walmsley and Dr Amy Berntson discussing models of deafness in the Synapse and Hearing Laboratory
Dr Charmaine Simeonovic (centre) and her team gratefully received a cheque to support their research into Type 1 Diabetes
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04 Voluntary Service to Outside Organisations 2004Staff and students of the JCSMR are involved in many research related activities which extend beyond their laboratory work.
Ada Professor GLMember: Australian Infl uenza Vaccine CommitteeMember: Programme Advisory Committee and Programme Executive Committee of the Australian HIV Vaccine Consortium (Director, Professor David Cooper, NCHECR)Scientifi c Patron: Austin Research Institute, Melbourne
Baker Dr RTPresident and Executive Director: Genome Conference IncExecutive Director and Honorary Treasurer: The Australian Society for Medical ResearchExpert Consultant: Human Gene Nomenclature Committee, London
Berntson Dr AStudent Advisor: The Canberra College, Phillip, ACT. Basics of the nervous system, hearing, and deafness
Board Professor PGMember: Pharmaceutical Subcommittee of Australian Drug Evaluation CommitteeAdvisor: Parkinson’s NSW Inc
Chaudhri Dr GHonorary Secretary: Australasian Society for Immunology Inc
Easteal Professor S Member: Advisory Board Sydney University Biological Informatics and Technology CentreResearch Committee: Australian Institute of SportBioinformatics Industry Opportunity Taskforce: Department of Industry, Science and Resources
Foster Professor PSMember, Executive Committee: International Eosinophil Society
Freeman Dr CMember: Canberra Region Scientifi c Meeting Planning CommitteeAdvisor: ACT cancer website: http://www.hotkey.net.au/~string/listing
Goodnow Professor CDeputy Chair: NHMRC Project Grants Review Panel 2a
Gready Professor JEConvenor: Australian Society for Biochemistry and Molecular Biology Bioinformatics Special Interest Group
Hendry Professor IScience advisor: Board of the Wenkart FoundationMember: John James Memorial Ethics Committee
Hill Professor CCardiovascular Health Advisory Committee: National Board of the Heart FoundationACT Representative: ANZ Microcirculation Society
In addition to the activities listed below, JCSMR staff and students speak with community groups and
interested members of the public, assist in the organization of conferences, are members of numerous
editorial boards, and assess for a wide range of national and international granting bodies.
81
Voluntary Service 2004
Voluntary Service to Organisations Outside JCSMR
Hulett Dr MACT councillor: Australasian Society of ImmunologyACT deputy convenor: Australian Society for Medical Research
Matthaei Dr KIConsultant: Australian Quarantine Inspection ServiceMember: NHMRC Training Awards Scholarships CommitteeMember: Stem Cell Independent Ethics Advisory Committee
Parish Professor CEditor-in-Chief: Immunology and Cell BiologyMedical Research Advisory Committee: Australian Cancer Research FoundationChair: NHMRC Research Fellowships Committee Peer Review Advisory PanelMember: NHMRC Research Fellowships CommitteeRepresentative: Program Management Committee, Australian HIV Vaccine ConsortiumPresident: Australasian Society for Immunology IncAustralian Representative: General Assembly of the International Union of Immunological Societies (IUIS) Elected Council member: IUIS CouncilCouncil member: Australasian Society of Clinical Immunology and Allergy
Ramshaw Professor IAScientifi c Advisory Panel Member: Westmead Institute for Cancer ResearchMember: Smallpox Expert Committee
Redman Professor SJTreasurer: International Brain Research OrganizationBoard Member: Neurosciences Australia LtdMember: National Neuroscience Task ForceChair: 2004 Gordon Conference on Synaptic TransmissionResearch Advisory Board Member: Prince of Wales Medical Research Institute
Schyvens Dr COrganizing Committee Member: Medical Research Week Expo, Australian Society for Medical ResearchSecretary, ACT Branch: Australian Society for Medical Research
Shannon Professor MFEditor: FEBS Letters (The Journal of the Federation of European Biochemical Societies)
Simeonovic Dr CJElected member of Council, Society Liaison Offi cer and Education Offi cer: The Transplantation Society of Australia and New Zealand
Stuart Dr GMember: GRP 4b, National Health and Medical Research Council of AustraliaSub Editor: American Journal of Respiratory Cell and Molecular Biology
82
Voluntary Service to Organisations Outside JCSMR
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04
Thomson Dr SAOrganiser: Basic Science Program, Australasian Society for HIV Medicine, Canberra
Tremethick Dr DJInvited analyst: Chemtract
Welsh Professor A Counsellor: Canberra Branch of the Statistical Society of Australia Inc
Whitworth Professor JAHonorary Ambassador for WomenAmbassador for CanberraTrustee: High Blood Pressure Research Council of AustraliaDirector: Research AustraliaDirector: Australian Phenomics FacilityCouncil Member: Charles Darwin UniversityBoard Member: Menzies School of Health ResearchChair: Research and Development Advisory Committee, The George Institute Chair: Scientifi c Advisory Committee for the Study of Health Outcomes in Aircraft Maintenance Personnel (SHOAMP), Commonwealth Department of Veterans AffairsMember: National Health and Medical Research CouncilMember: Global Advisory Committee on Health Research, WHOMember: WHO Expert Advisory Panel on Health Science and Technology PolicyMember: WHO/ISH Liaison CommitteeCo-Chair: WHO/ISH Guidelines Writing CommitteeMember: ISH International Scientifi c Program Committee Member: Mayne Florey Medal Selection CommitteeMember: Specialist Medical Review Council, Commonwealth Department of Veteran’s AffairsChair: Selection Panel for the Commonwealth Health Minister’s Award for Excellence in Health and Medical ResearchDirector: Australian Science Festival Ltd (ASF)Patron: Technical Aid to the Disabled, ACT (TADACT)Patron: The Wesley Research Institute LtdChair: National Neuroscience Taskforce
Willenborg Dr DOMember, International Advisory Board: International Society of NeuroimmunologyMember: Research Advisory Board of the Australian Institute of Sport
Young Professor IGEditor: DNA SequenceMember: Biological Defence Advisory Committee, (Department of Defence)
Support to the School
• Grants
• Statistics
• Donors
The John Curtin School of Medical Research Annual Review 2004
84
Gra
nts
2004 Grants 2004
ACT Health and Medical Research Support ProgramDr Z Kecskes (Canberra Hospital) and Professor I HendryProtein 14-3-3 in CSF following hypoxia-ischaemia$16,592
ANU Major Equipment GrantProfessor MF Shannon, Dr DJ Tremethick, Dr KI Matthaei, Dr D Webb and Dr SP HoganQuantiying gene expression: a realtime PCR detection system$86,405
ANU Medical School Research Fund Seeding GrantDr Z-M SongEffects of α2 adrenoceptors on dendritic spine formation in vitro$50,000
ANU Teaching Equipment GrantProfessor C Hill$18,967
Australian Institute of Nuclear Science and Engineering (AINSE) Dr DO WillenborgEvaluation of radiolabelled peripheral benzodiazepine receptor (PBR) ligands in the animal model “experimental autoimmune encephalomyelitis”. Potential probes for the diagnosis of “Multiple Sclerosis”$15,840
Australian Research Council Centre of Excellence Grant Professor P Gresshoff, Professor C Beveridge, Dr B Carroll, Professor B Rolfe, Professor C Parish, Dr M Djordjevic, Dr G Weiller, Dr U Mathesius, Dr R Rose, Professor M Singh and Dr P BhallaIntegrated legume research$2,000,000
Australian Research Council Discovery GrantsDr RT BakerRole of a novel zinc-binding motif in the structure-function of deubiquitinating enzymes$75,000Professor PG Board Agenomic and phenomic investigation of a mitochodrial glutathione transferase$80,000
Professor PG Board, Professor AF Dulhunty and Professor PW Gage CLICVs and GSTs : New ion channel modulators$131,500
Professor S Easteal, Dr GA Huttley, Dr AV Isaev and Dr MJ Wakefi eldAdaptive evolution of BRCA1 in ancestral mammals$75,000
Professor S Easteal, Dr K North and Dr R Trent (Sydney University)Discovering genes which modify human physical performance: a means of developing healthier life styles and novel athletic training programs
Dr JE Gready, Dr PL Cummins, Dr AA Bliznyuk (ANUSF), Professor U Rothlisberger (EPFL, Lausanne), Professor S Ragsdale (UNebraska)Towards a complete description of how enzymes work: development of simulation methods and protocols, blind test predictions, and experimental validation $85,000
Professor TD LambSuction pipette measurements of mammalian rod photoreceptor recovery following intense bleaching exposures$60,000
Dr DJ TremethickMechanisms of higher–order chromatin folding $142,000
Professor S R WilsonStatistical advances in the Post-Genome Era$85,000
85
Grants 2004
Grants
Australian Research Council Linkage Grants Dr HS Booth, Dr GA Huttley, Dr A Isaev and Cray Australia P/LBioinformatics Software Development $6,250
Dr MG CasarottoMolecular Interactions of chemical agents with ion channel proteins$70,000
Dr CJ Easton and Dr MG Casarotto Synthetic compounds to specifi cally activate or inhibit ryanodine receptor calcium ion channels$68,000
Professor TJ Andrews (RSBS), Dr JE Gready and Professor G Otting (RSC)Why is the photosynthetic CO2-fi xing enzyme, Rubisco, so ineffi cient? Dissection of the catalytic chemistry by computational simulation and experimental testing$215,000
Dr B Garner, Professor C Parish, Dr C Freeman, Dr PP Gray, Dr MJ Davies and Dr M Guilhaus A glycobiology facility for glycoconjugate analysis and oligosaccharide sequencing$343,608
Professor M Sheil, Dr S Blanksby, Dr J Beck, Associate Professor M Wilson, Associate Professor RJW Truscott, Associate Professor J Carver, Professor M Walker, Dr P Keller (Wollongong), Dr NE Dixon, Professor G Otting, Professor B Rolfe (ANU), Professor IG Young, Professor L Mander (Auckland)New directions in biomolecular mass spectrometry$555,910
Centre for HIV VirologyProfessor IA RamshawNovel approaches for HIV-1 vaccination$150,000
Clive & Vera Ramaciotti FoundationProfessor JA Whitworth and Dr Y Zhang$10,000 - equipment
Diabetes Australia Research Trust GrantsProfessor MF Shannon and Dr CJ SimeonovicMolecular mechanisms for the survival of islet tissue allografts and xenografts: a role for the transcriptional factor c-Rel$40,000
Dr CJ Simeonovic, Professor IA Ramshaw, Dr G Hoyne and Clinical Associate Professor JD WilsonDendritic cell-based immunotherapy for the re-establishment of self-tolerance to islet beta cells in NOD mice$40,000
Fexible Learning FellowshipDr HS Booth Postgraduate course development - Bioinformatics$37,248
Hellenic Republic, Ministry for Development Professor CE Vorgias and Dr MG Casarotto Solution Structure of a 40 kDa thermostable TIM barrel type chitinase: mechanistic insights. Molecular recognition and substrate hydrolysis of chitin related enzymes$100,452
Howard Hughes Medical Institute, USADr G KarupiahImmune response to viral infection$93,000
Human Frontiers Science FoundationProfessor SJ Redman, Professor T Jessell (University of Columbia), Professor R Brownstone (Dalhousie University), Professor L Ziskind-Conhaim and Professor M Jackson (University of Wisconsin) andA Todd (University of Glasgow)Physiological functions of genetically distinct classes of ventral spinal interneurones$50,000
ICE-EM grant Bioinfosummer 2004 Symposium in Bioinformatics Dr C Burden, Dr HS Booth and Dr L SantosoGenome to phenome modelling$25,000
86
Gra
nts
2004
Grants
International Union against Cancer Professor A Sobolev (Moscow State University), Professor I Young and Dr A Oakley (RSC, ANU)Crystallization of a multi-domain transporter developed to kill cancer cells$3,163
National Health and Medical Research Council Capacity Building GrantProfessor T Dwyer, Dr G Jones, Dr A Venn, Dr L Blizzard, Professor S Easteal, Dr A-L Ponsonby, Professor P ZimmetBuilding Australia’s capacity to study preventable causes of common diseases through epidemiological research$500,000
National Health and Medical Research Council Equipment GrantDr M HulettAmaxa Nucleofector Device$32,000
National Health and Medical Research Council Program GrantsProfessor C Chesterman (UNSW), Dr R Andrews (Monash), Dr M Berndt (Monash), Professor B Chong (UNSW), Professor P Hogg (UNSW), Dr M Hulett, Associate Professor L Khachigian (UNSW) and Professor C ParishVascular Biology$2,000,000
Professor P Doherty, Professor IA Ramshaw, Professor D Cooper and Associate Professor S KentStudies of HIV-1 infection and vaccination$350,000
National Health and Medical Research Council Project GrantsDr J M BekkersSynaptic integration and plasticity in the rat piriform cortex$80,000
Professor PG Board The role of Zeta and Omega class glutathione transferases in endobiotic and xenobiotic metabolism$160,000
Dr G Chaudhri and Dr G KarupiahPathophysiological signifi cance of reverse signalling through membrane TNF$50,000
Dr G Chaudhri and Dr G KarupiahCritical role of TNF in host-virus interactions and outcome of infection: Involvement of reverse signalling through mTNF$165,000
Professor AF Dulhunty, Professor PG Board and Dr MG Casarotto Protein/protein interactions between two calcium channels $130,000
Professor AF Dulhunty, Professor GD Lamb, andDr MG Casarotto Specifi c modifi cation of RyR activity $130,000
Dr R Kumar and Professor PS FosterCytokines regulating airway infl ammation, remodelling and hyperreactivity in chronic asthma$114, 000
Professor PS Foster, Dr SP Hogan, Dr KI Matthaei, Dr PI Thompson and Professor IG YoungMolecular mechanisms in the regulation of allergy and infl ammation$970,000
Professor C GoodnowGenetic and biochemical mechanisms dysregulating CD4 T cell tolerance$145,000
Professor C Goodnow and Dr C VinuesaMechanisms controlling antibody production and B cell signalling$150,000
Professor I HendryThe proteins associated with the neurotrophin retrograde transport signalling endosome$95,000
Professor C Hill and Dr T GraysonMyoendothelial gap junctions: their composition and role in vasodilator responses attributed to EDHF$85,000
Professor D Hirst and Dr F EdwardsInvolvement of ICC in control of gastric antral motility$300,000
87
Grants 2004
Grants
Dr G KarupiahControl of infl uenza virus infection by gamma interferon induced mediators$25,000
Dr NJC King, Dr G Karupiah, Dr AM Kesson and Dr G ChaudhriCritical soluble effector molecules causing immune damage in a model of West Nile virus encephalitis$87,500
Professor TD LambElectroretinogram recordings of human scotopic dark adaptation following intense bleaching exposures$119,000
Professor SJ Redman and Dr C RaymondThe contributions of different sources of calcium to the induction of long-term potentiation$85,000
Professor MF Shannon The role of c-Rel in T cells gene transcription: a model of chromatin remodeling.$152,000
Professor MF Shannon and Dr A Holloway A functional proteomics approach to the study of inducible gene transcription in a chromatin context$150,000
Dr CJ Simeonovic and Professor A GibbsMajor xenoantigens for neovascularised porcine xenografts: the role of PERV and MHC in rejection and tolerance$160,000
Dr GJ StuartDendritic mechanisms underlying synaptic plasticity$95,000
Dr D Tremethick and Dr P RidgwayThe function of an essential histone variant during early development$145,000
Professor B WalmsleySynaptic transmission in the central nervous system$145,000
Dr HS WarrenReceptors and ligands regulating human NK cell proliferation$136,242
Dr DO WillenborgThe role of interferon-gamma and nitric oxide in the downregulation of central nervous system infl ammation $160,000
National Health and Medical Research Council Senior Research FellowshipsDr G Karupiah$112,500Dr HS Warren$109,750
National Heart FoundationProfessor C Hill and Dr T GraysonGrant-in-Aid$49,833
National Institutes of Health, USADr EM Bertram and Professor C GoodnowGenes for tolerance and immunity consortium supplement: Screening a unique library of mouse genome variants for genes and mechanisms necessary to enhance CD8 T cell responses in anti-viral immunity$284,064
Professor MV Anders and Professor PG Board The metabolism and toxicity of halogenated hydrocarbons$103,630
Professor C GoodnowGenes for tolerance and immunity consortium$795,798
Professor IA Ramshaw and Dr SA ThomsonHIV vaccine design and development program$376,000
NSW Cancer CouncilProfessor C Parish, Dr J Altin (BaMBi, ANU) and Dr P Hogg and Professor C Chesterman (UNSW)Tumour angiogenesis$196,000
Praxis PharmaceuticalsDr WB Cowden and Dr B CharltonInvestigation of phosphosugars as anti-infl ammatory drugs$375,000
88
Gra
nts
2004
Grants
The Canberra Hospital Private Practice FundDr D Croaker and Dr P Overliet (Canberra Hospital) and Dr Z-M SongModifying the aganglionic phonotype in rats and men: investigations into the role of genes and lipids in the aetiology of Hirschsprung’s disease$50,000
Dr DO Willenborg, Dr H Warren, Dr M Cook and Dr N PetrovskyA multiscan plate reader$21,388
Viertel Senior Medical Research FellowshipDr M HulettRegulators of cell invasion and angiogenesis$165,000
Wellcome TrustProfessor C GoodnowMolecular analysis of pathways in diabetes$660,000
89
Statistics 2004
Income
Base Allocation $13,942,000
IGS, RTS, RIBG $3,905,000
Adjustments $413,000
Other Income $2,154,000
Special Purpose Funds (SPF) $15,815,000
TOTAL INCOME $36,229,000
Expenditure
Staff Costs $13,291,000
Scholarships $1,186,000
Equipment $1,588,000
Travel $704,000Expendable Research Material (ERM) $2,150,000
Other $2,284,000
Special Purpose Funds (SPF) $15,815,000
TOTAL EXPENDITURE $37,018,000
Special Purpose Funds
Overseas Grants $1,468,000
Government Grants $12,841,000
Australian Business $74,000
Other $1,432,000
TOTAL $15,815,000
Statistics 2004
Staff Numbers 2004 2003 2002
Academic staff 96 85 76
General Staff — administration, technical & support 212 172 176
Postgraduate students 76 77 84
The number of JCSMR staff has increased signifi cantly in response to our continued success in attracting external research
funding. In addition the Australian Phenomics Facility was completed in 2004 and is now fully operational.
90
Don
ors
2004
We would particularly like to thank in 2004• Professor Gordon Ada
• BOC Ltd
• Canberra Institute of Technology
• Mrs Meg Chapman
• Mr Luigi and Mrs Assunta Corbo
• Mrs Susan Daw
• Figtree Travel Centre
• Professor Joe Gani
• Mr Peter and Mrs Joan Hurst
• Mr John Kerr and Family
• Newman Estate
• Family and Friends of Mr David Edwin Nicol
• Mrs Val Nicol
• Probus Club of Gungahlin
• Mr Ian and Mrs Thelma Rigby
• Rotary Club of Canberra – Weston Creek
• Family and Friends of Mr Edward John Spruce
• Mr Robert and Mrs Valerie Tupper
• Wyeth Australia Pty Ltd
The John Curtin School of Medical Research Needs Your Support
Gifts and bequests to the School are used to fund vital research projects in areas such as asthma, cancer,
diabetes, high blood pressure, hearing loss and vision, as well as providing scholarships and purchasing
specialised equipment. Your support can be provided in a number of ways. These could include a gift or
bequest that may assist in funding a particular area of research, or a scholarship or prize.
If you would like to discuss options for supporting The John Curtin School of Medical Research, please
contact:
Dr Madeleine Nicol
T: +61 2 6125 2577 F: +61 2 6125 2337 M: 0407 278 913
Donors 2004
The Director, staff and students of the John Curtin School of Medical Research are extremely grateful for continued support from our donors.
Published in Australia by
The John Curtin School of Medical Research
The Australian National University
Editor: Dr Madeleine Nicol
Design & Layout: Sue Henderson
Photography: Marc Fenning
Additional Photographs: Karen Edwards & Julie Macklin
The John Curtin School of Medical Research
The Australian National University
Building 54, Mills RoadActon ACT 0200
Australia
T: +61 2 6125 2550F: +61 2 6125 2337
W: jcsmr.anu.edu.auhttp://annualreport.jcs.anu.edu.au/2004/