The role of Oat Beta Glucan and

Water Soluble Tomato Concentrate

in improving heart health and

preventing disease

Dr Rob Winwood CSci FIFST – Scientific Communications

Manager EMEA

14:50 Wednesday, November 18th, 2015 at Food Matter Live, Room 16, Excel, London

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Programme

1. Nutritional ingredients interventions for cardiovascular

health

2. Water soluble tomato concentrate

3. Oat beta glucan

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• Cardiovascular disease was virtually

unknown one hundred years ago

• Today, One in Four of us will die of it.

• How can we improve things?

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Nutrients for cardiovascular health

• Targeted nutritional interventions can have a major effect in delaying or even

preventing, the onset of cardiovascular disease

• This presentation will consider nutritional interventions with oat beta glucan and

water soluble tomato concentrate that have an existing EFSA 13.1 Health Claim

relating to cardiovascular health, with particular attention to maintaining good

blood circulation and healthy blood lipid profiles.

• DSM offers a wide range of heart healthy ingredients under our “Guard your Heart”

health benefit solutions, see the following link:

http://www.dsm.com/en_US/foodandbeverages/public/home/pages/sol-guard-

your-heart.jsp

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Nutrition and heart health

4

Nourish your heart

• Small dietary changes can lead to a large

reduction in the burden of CVD

• Improving your diet is a key factor in preventing and

managing cardiovascular diseases

• Numerous scientific studies showed that

nutrients can reduce the risk of CVD and

promote a healthy heart

• Nutritional epidemiology showed that specific

nutrients play a key role in maintaining a

healthy heart

Source: International Osteoporosis Foundation www.iofbonehealth.org

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Examples of Risk Factors:

• Stress

• Smoking

• Obesity,

• Sedentary lifestyle

• Dyslipidemia

• Hypertension

• Genetic predisposition

• Metabolic syndrome

• Poor diet (high

salt/trans-fats)

• Infection

Cardiovascular Disease

Proven treatment interventions:

• Exercise

• Reduce blood pressure

• Regularise blood lipid profile

• Reduce inflammation

• Reduce blood viscosity/clotting

CVD is a multi-factorial disease.

The efficacy of any nutritional

intervention thus needs to be determined

by a relevant basket of validated

biomarkers

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Cardiovascular diseases: Disorders of the heart and blood vessels

Coronary heart disease (CHD)

• Myocardial infarction (heart attack)

• Angina pectoris (chest pain)

• High blood pressure (hypertension)

• Congestive heart failure

• Stroke

• Congenital cardiovascular defects

• Arrhythmias (disorders of heart rhythm)

• Diseases of arteries

• Atherosclerosis

• Peripheral arterial disease

• Rheumatic heart disease

• Vascular heart disease

• Venous thrombo-embolism

Cardiovascular diseases

There are many forms of cardiovascular diseases

• 50% of individuals who die suddenly of CHD have no previous symptoms of the diseases

• 95% of people who have a sudden cardiac arrest die from it, often within minutes

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Six ways to improve the workings of a healthy heart

1. Promote healthy heart function

2. Promote healthy blood lipids

3. Prevent LDL cholesterol

oxidation 4. Promote healthy blood

pressure

5. Support healthy circulation

and blood vessels

Marine omega 3 Oils

Oat beta glucans and

olive polyphenols

Water soluble tomato

concentrate

6. Prevent inflammation

(of vascular epithelium)

α tocopherol

Water soluble tomato concentrate,

scientifically substantiated solution for

healthy blood flow

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Vascular function & the platelets: support healthy blood flow

• The platelet are small, disk-shaped anuclear cell fragments derived from megakaryocytes in bone marrow

• Platelets have numerous surface receptors which are activated by various agonists

• Platelet reactivity is key necessary to stop bleeding upon damage of our blood vessels

• Early stages of atherosclerosis lead to low grade inflammation and platelet hyperreactivity which participate in the development of heart diseases

• A reduction in platelet hyper-reactivity could reduce atherosclerosis plaque development and improve long term heart health

• Thus reducing platelet hyper-reactivity will support a healthy blood circulation

Platelet surface

receptors

Activated platelet

Inactive platelets

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What is Fruitflow®

• The first natural, scientifically sustantiated solution for healthy blood flow

• Fruitflow® is a breakthrough ingredient. In human trials it has shown to reduce platelet

aggregation and improve blood flow and works in 97% of subjects. The effect takes place

within 1.5 hours of consumption and lasts for up to eighteen hours after a single dose.

The effect is maintained if taken on a daily basis.

• It is a water-soluble, tomato based concentrate containing multiple active constituents

• Fruitflow® is the first ingredient with an EFSA Art 13.5 health claim.

“Helps maintain normal platelet aggregation, which contributes to healthy blood flow”

• Natural, healthy and safe . Highly stable and water-soluble, low flavour, odour and

colour profile and suitable for use in food, bevergages & dietary supplement

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Multiple (8 ) human trials confirm Fruitflow®

reduces platelet aggregation safely

– No side effects reported

– Works in 97% of subjects

– Starts to work within 1.5 hours and continues for 12 to 18 hours

– When taken regularly on a once per day basis, the effect is continuous

Fruitflow® is a breakthrough anti-thrombotic ingredient

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Setting the scene

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Blood vessel with wound

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Platelets are activated, get spiky, coagulate and form a clot to stop the bleeding

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….and platelets start to coagulate

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and can form unwanted clots

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Non activated /smooth platelet Activated / spiky platelet Blood clot

• Platelets can become “spiky” i.e. more prone to clotting due to a

variety of factors like stress, overweight, high cholesterol.

• Fruitflow works by keeping blood platelets smooth to

avoid aggregation inside blood vessels.

•Fruitflow® is the only functional food ingredient addressing platelet aggregation, the cause of blood clots

Fruitflow® acts on the first stage of the clotting process: Platelet activation

• Fruitflow does not

disrupt the rest of the

blood clotting process so

clotting will still take

place as usual after injury.

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Blood Clotting and Coagulation – How Does Fruitflow® Work?

Injury; roughening of

wall(artherosclerosis, aging,obesity,

diabetes, WBC-platelet aggregates)

Platelets activated:

RBC

resting

platelet

endothelial

activated

platelet

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Fruitflow® inhibits markers and mediators of platelet aggregation

activation & aggregation

1.changes shape

“pseudopods”

“sticky”

2a. P-selectin

GPIIb/IIIa

(binds FBN)

2b. membrane

phospholipids

PL

ARA

PG2

COX

TX A2 thrombospondin

+

ADP, collagen

Ca2+ thrombin fibrin

PT CF CF FBN

Vitamin K

FF

activated

platelet

(soft clot)

Fibrin

(firm clot)

CF

clotting factors

prothrombin

fibrinogen

PT

FBN

ASPIRIN

FF • Fruitflow works on

multiple aspects of the

initial clotting mechanism

• Aspirin works on only one

specific pathway

• Fruitflow effect is

reversible, Aspirin effect is

not

• Fruitflow exerts

~30-50% the inhibition

induced by LD-aspirin

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Analytics of Fruitflow

• Fruitflow is a natural

multi-component product

• Representative marker

selected

• Adenosin

• Chlorogenic acid

• Rutin

• 3 major compound clusters

• Nucleosides (AF 1)

• Polyphenols (AF 2)

• Flavonoids (AF 3)

Page Oat beta glucan

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OatWell® oat bran

The beneficial properties of oat are attributed to the soluble fibers found in oat, which are called beta-glucan. In OatWell® oat bran the natural viscous fibers are present in high amounts due to a careful milling & sieving process of oat bran.

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To maintain the functional attributes of beta-glucan = viscous polysaccharide

(1 3), (1 4)- ß-D-glucan, it is important to control and analyse the key

parameters in the food matrix.

Functionality of OatWell® oat beta-glucan

Functional key-parameters of oat beta-glucan to

ensure the adequate viscosity in the gut:

• Beta-glucan concentration

• Molecular weight

• Solubility / Viscosity

Functionality can be reduced due to:

• extraction

• uncontrolled processing

• enzymatic influence

• excessive heat or pressure

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Oat beta-glucan: Health benefits

Blood glucose

Control

(Diabetes)

Cholesterol

lowering

(Heart Health)

Weight

Control

(Obesity)

Functionality drivers

3-4 grams bioactive oat beta-glucan daily required

Gut Health

(IBS)

EFSA art. 14

EC approved EFSA art. 13.1

EC approved

Project:

EFSA art. 13.5 EFSA art. 13.1

EC approved

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Scientific evidence:

• Over 50 human studies

• 3 Meta analysis

• Proven physiochemical properties of bioactive OatWell® oat beta-

glucan

Regulatory approvals:

• EFSA (art. 14) / FDA / FASANZ / ASIA / HC

Opinion leaders:

• Supported by WHO

• International cholesterol lowering education programmes (National

Cholesterol Education Program; JAMA, 2001)

• American Dietetic Association

• European Society of Cardiology and European Arteriosclerosis Society

(ESC/EAS) Guidelines for the management of dyslipidemias recommend consumption of oat beta-glucan as

one strategy to reduce LDL cholesterol

Science & Regulatory

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Dietary fibre

Available evidence consistently demonstrates a TC- and LDL-C-lowering effect of water-

soluble fibre from oat bran (ß-glucan). Foods enriched with this fibre are well tolerated,

effective and recommended for LDL-C-lowering.

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EU claim for Oat Beta Glucan

Claim: • “Oat beta-glucan has been shown to reduce blood cholesterol. High cholesterol is a

risk factor in the development of coronary heart disease.”

Conditions of use: • The beneficial effect is obtained with a daily intake of 3g oat beta-glucan. The claim

can be used for foods which provide at least 1g of oat beta glucan per quantified

portion.

Target customers:

• Health conscious consumers

• People with increased

cholesterol levels

• People with high cholesterol

levels and additional CHD risk

factors

14% 22% 28%

Dosage 1g BG /

serving

7.1 g 4.5 g 3.6 g

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Summary: nutrients for your heart

Heart health benefits Nutrients

Blood lipid Omega-3 LC-PUFA (EPA, DHA), oat beta

glucan, olive polyphenols

Oxidative stress Vitamin C and E,

Blood pressure Omega-3 LC-PUFA (EPA, DHA), CoQ10,

vitamin D

Vascular function Omega-3 LC-PUFA (EPA, DHA), vitamin E,

water soluble tomato concentrate

Heart function Omega-3 LC-PUFA (EPA, DHA), CoQ10

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