the school of public health kenneth d. ward, phd university of memphis, and syrian center for...
TRANSCRIPT
The School of Public Health
Kenneth D. Ward, PhD University of Memphis, and
Syrian Center for Tobacco Studies
What do we know about treatment for waterpipe addiction?
1st International Conference on Waterpipe Research, Oct 20-23rd, 2013, Abu Dhabi
Taghrid Asfar, MDUniversity of Miami, and
Syrian Center for Tobacco Studies
Goals
• Waterpipe dependence features• Are waterpipe smokers interested in quitting?• A pilot randomized trial of a behavioral
cessation program• Recommendations
DSM-IV nicotine dependence criteria
• Tolerance• Nicotine is often taken in larger amounts or over a
longer period than was intended• Withdrawal• Persistent desire or unsuccessful efforts to cut down or
control use• Great deal of time spent in activities to obtain nicotine• Important social, occupational, or recreational
activities given up or reduced because of nicotine• Use is continued despite knowledge of problems it
causes
Tolerance: increased use with time
“On holiday . . . I looked at my mum and said ‘Can I try it?’ Then I used to do it with my friends every once in a while, very rarely. When I got to university I started smoking it a little bit more. Then we got one in the flat and we started to do it a lot more.”
(Jawad et al., IJTLD, 2013)
“Due to the boredom of having free time, I used to go with my friends to a cafe. When they invited me to try narghile, I found it interesting and good. I felt some dizziness, but I enjoyed the taste and the smell. It was fun. And so I became a daily smoker.”
(Hammal et al., Tobacco Control, 2008)
Withdrawal
“I once tried to quit, but I could not manage without smoking narghile for more than 2 days. I felt the craving, and during those 2 days, I tried to fill my time with something else because as long as I had free time, I thought about the narghile.”
Hammal, Mock, Ward, et al., Tobacco Control, 2008
Abstinence-induced withdrawal and craving?
Maziak, Rastam, Eissenberg et al., NTR, 2009
0
10
20
30
40
100
Pre Post
Time (relative to waterpipe smoking)
Scor
eUrgeRestlessnessCraving
Drug seeking behavior
Loss of autonomy, smoking cues
“I like to dominate everything, but the narghile has completely dominated me. That bothers me. My happiness is related to the narghile.” (Hammal, et al., 2008)
“When I’m walking from the train station to my house, I get a really nice smell of shisha flavors sometimes if the wind is blowing in the right direction” (Jawad et al., 2013)
Factors related to level of waterpipe useMonthly
OR (95%CI)Weekly
OR (95%CI) Daily
OR (95%CI)
ref 1.0 (0.5-2.0) 3.3 (1.1-10.1) Gender (male)
ref 1.9 (0.5-8.3) 6.7 (1.3-33.6) Smoking narghile mainly alone
ref 0.6 (0.3-1.2) 0.3 (0.1-0.8) Share the same narghile
ref 4.3 (0.9-21.5) 30.6 (5.2-179.6) Place of usual smoking (home)
ref 1.8 (0.8-3.9) 6.8 (2.3-19.7) Smoke now more frequently than when started
refrefref
ref2.5 (1.6-5.2)
4.1 (0.5-36.2)
ref3.8 (1.27-11.6)
42.2 (4.2-428.2)
Hooked on narghileNot hookedSomehow hookedVery hooked
ref 1.9 (1.0-3.6) 1.5 (0.6-4.2) Narghile is important for selecting cafe/restaurants
ref 2.3 (1.0-5.0) 2.1 (0.7-6.2) Carry narghile with if needed
Maziak, Ward, & Eissenberg, Drug and Alc Dep, 2004
Do you think you can quit smoking narghile
anytime you want?
96 89.9
68.2
0
20
40
60
80
100
Monthly Weekly DailyFrequency of narghile use
%
p<.0001
Ward, Eissenberg, Rastam, et al., Tobacco Control, 2006
Made a quit attempt in past year
Ward, Eissenberg, Rastam, et al., Tobacco Control, 2006
Are you interested in quitting narghile smoking?
33.8
29.5
20.3
0
5
10
15
20
25
30
35
40
Monthly Weekly DailyFrequency of narghile use
%
Ward, Eissenberg, Rastam, et al., Tobacco Control, 2006
Which waterpipe smokers want to quit?
Waterpipe user characteristics:Bahrain and Syria
Bahrain (n=380)
Syria (n=268)
Age (mean, yrs) 29 30
Male (%) 92 60Years smoked WP (mean) 9 6Daily users (%) 61 20“Hooked” on waterpipe
SomewhatVery
4213
4014
Interested in quitting (%) 40 28Believe can quit anytime (%) 82 86“Protect health” is major reason to quit (%) 85 90
Correlates of interest in quitting waterpipe -- Syria
Variable Odds Ratio 95% CI p
Years smoking 0.92 0.87 - 0.99 .0182
Increased use 0.55 0.30 - 0.99 .0475
Married 2.30 1.24 - 4.24 .0078
Family doesn’t smoke 2.04 1.12 - 3.72 .0196
Family disapproves 2.12 1.15 - 3.91 .0159
Ward, Hammal et al., Nic Tob Research, 2005
Correlates of interest in quitting waterpipe -- Bahrain
Variable t p
Physician recommended quitting 2.87 .004
Non-Bahraini citizen 3.30 .001
Family hostile toward WP 2.41 .016
Not “hooked” on WP 2.00 .046
Borgan, Marhoon, & Whitford, Nic Tob Research, 2013
Correlates of interest in quitting waterpipe– Aleppo Household Survey
Variable Odds Ratio
95% CI p
Live in “informal” zone 2.07 1.10-3.90 .0235
Frequency of eating fruit 0.65 0.49-0.86 .0029
Interest in quitting cigarettes
Non-Cigarette smoker REF
Not interested in quitting cigs 0.23 0.10-0.58 .0016
Interested in quitting cigs 2.03 1.10-3.76 .0247
Ward et al., under review
Variables NOT associated with interest in quitting WP
• Demographics– gender, marital status,
religion, education
• Psychosocial– social support,
depression
• Health behaviors– vegetable intake,
physical activity, sports
• Health conditions– overall self-rated health,
cancer, heart disease, respiratory diseases
• Waterpipe use– frequency of use (daily
vs. non-daily), perceived difficulty of quitting
If we build it, will they come?
Efficacy of Behavioral Counseling is Dose-dependent…at Least Up to a Point
Total amount of contact time
Number of arms
Odds Ratio (95% C.I.)
Abstinence Rate (95% C.I.)
No minutes 16 1.0 11.0
1-3 minutes 12 1.4 (1.1, 1.8) 14.4 (11.3, 17.5)
4-30 minutes 20 1.9 (1.5, 2.3) 18.8 (15.6, 22.0)
31-90 minutes 16 3.0 (2.3, 3.8) 26.5 (21.5, 31.4)
91-300 minutes 16 3.2 (2.3, 4.6) 28.4 (21.3, 35.5)
> 300 minutes 15 2.8 (2.0, 3.9) 25.5 (19.2, 31.7)
Source: Fiore et al., 2000
Behavioral cessation treatment of waterpipe smoking: a pilot RCT
• 50 adult WP users (≥ 3 times/wk), non-cigarette smokers, interested in quitting
• Randomized to brief (1 session + 3 phone calls) or intensive (3 sessions + 5 phone calls) behavioral treatment
Asfar et al., under review
Behavioral treatment strategy
• Education about health effects/consequences• Set specific quit day• Stimulus control: quit ritual, social support,
coping skills, physical activity• Contingency management: self-rewards• Problem solving and relapse prevention
Asfar et al., under review
Asfar et al., under review
Baseline characteristicsDemographics
Brief (n=23)
Intensive (n=27)
Men (%) 96 93Age (mean, SD) 30 (11) 29 (8)High school grad (%) 71 58Married (%) 44 44Muslim (%) 87 83
Asfar et al., under review
Baseline characteristicsTobacco Use
Brief (n=23)
Intensive (n=27)
Age began smoking WP 31 29Years smoking WP 7 4Daily WP user (%) 70 85Carbon monoxide level (ppm) 13 (19) 16 (20)Very confident about quitting (%) 44 41Past year quit attempt (%) 74 67Quit for ≥ 1 month 35 30
Asfar et al., under review
Adherence and Retention
Brief (n=23)
Intensive (n=27)
Completed all face-to-face sessions (%) 78 37
Completed all phone calls (%) 39 41
Completed all face-to-face sessions and phone calls (%)
26 35
Completed 3 month f/u (%) 83 78
Asfar et al., under review
Process evaluation%
Interventionist was helpful 95
Program helpful 67
Most helpful strategiesGetting more activeReceiving educational informationFollowing “Rules of relapse”Getting social support
71715848
Preference for group counseling 33
Preference for medication 74Asfar et al., under review
Cessation rates at 3-month f/u(self-report + CO < 10ppm)
Brief(n=23)
Intensive(n=27)
p
Continuous 17 18 .61Prolonged 30 41 .317 day point prevalent 30 41 31
Asfar et al., under review
Absolute effect size: 11%Relative effect size: 37%Power: 12%Sample size needed for 80% power (2-tailed, α=.05) : 466
Predictors of prolonged abstinenceOR 95% CI
Demographics
Age 0.98 0.92-1.04
Married 1.76 0.55-5.58
High School grad 0.56 0.17-1.90
SES (Density index) 1.12 0.62-2.02
Employed 0.53 0.16-1.71
Muslim 2.67 0.28-25.84
Tobacco Dependence
WPs smoked/wk 0.91 0.43-1.91
Years smoked 1.03 0.92-1.16
Last year quit attempt 0.45 0.14-1.49
Quit confidence 2.74 0.78-9.61
Quit readiness 1.29 0.92-1.82
Baseline withdrawal 1.00 0.96-1.04
Prolonged Abstinence
EOT 6m 12m0
5
10
15
20
25
30
35
29.3
17.615.6
27.3
18.615.7 Nicotine
Placebo
Ward, Asfar, Al Ali et al., Addiction, 2013
Summary
• “Low hanging fruit”: brief interventions for less-dependent smokers who have good family support, and dual tobacco users who want to quit all tobacco
• For heavily dependent smokers, short-term quit rates in our behavioral treatment program were reasonable, but and there was no evidence that a more intensive behavioral program was more helpful than brief treatment
• Train physicians to deliver brief interventions• Test pharmacotherapy
www.scts-sy.org
Thank you!• Radwan Al Ali, MD• Taghrid Asfar, MD• Iman Ebrahim• Tom Eissenberg, PhD• Madonna Elias• Fouad Fouad, MD• Wasim Maziak, MD, PhD• Fawaz Mzayek, MD, PhD• Samer Rastam, MD, PhD