CURRICULUM VITAE

THOMAS F. LÜSCHER M.D., FRCP, FESC

I. CURRICULUM VITAE

A. Person and Education

B. Clinical Training and Activity

C. Staff Positions

D. Clinical Activity

E. Research Activities

F. Education and Publishing

II. SELECTED PUBLICATIONS

Address for Correspondence:

Thomas F. Lüscher, MD, F.R.C.P.

Professor of Cardiology Imperial College

Director of Research, Education & Development

Royal Brompton & Harefield Hospitals

London SW3 6NP, U.K.

Phone: +44 7502 008 487

E-mail: cardio@tomluescher.ch

Web: www.tomluescher.ch

London, September 26th, 2019

I. CURRICULUM VITAE

A. PERSON AND EDUCATION

Name Thomas Felix Lüscher

Nationality Swiss

Languages German, English, French, Italian

Marital status Married, two children

University degrees

Habilitation «Endothelial Vasoactive Substances and Cardiovascular Disease», (equivalent to PhD thesis), University of Basle, Switzerland

U.S. Medical Visa Qualifying Examination (V.Q.E.) Examinations Frankfurt, Germany

Certification of the Educational Commission for Foreign Medical Graduates (E.C.F.M.G.), Frankfurt, Germany

Doctoral thesis «Extrarenal manifestations of fibromuscular renovascular hypertension», University of Zurich, Switzerland

Academic positions

2018 – Present Professor of Cardiology, Imperial College, London

2004 – Present Professor of Cardiology, University of Zurich, Switzerland (20%)

1996 – 2004 Professor of Cardiology and Cardiovascular Physiology, University of Zurich, Switzerland,

1993 – 1996 Professor of Medicine (Cardiology), University of Berne, Switzerland

1992 – 1996 Professor of Medicine (Pharmacotherapy), University of Basle, Switzerland

1989 – 1992 Assistant Professor of Medicine (Privatdozent), University of Basel, Switzer-land

Board certifications

1989 Swiss Board of Cardiology

1987 Swiss Board of Internal Medicine

2017 License to Practice, Cardiology, General Medical Council, United Kingdo

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B. POSTGRADUATE TRAINING IN MEDICINE

Training in Internal Medicine and Cardiology

• Echocardiography Laboratory (Head: A.J. Tajik), Division of Cardiovascular Diseases and Internal Medicine, Department of Medicine, Mayo Clinic, Rochester, MN, USA

• Research Associate, Cardiovascular Physiology (Heads: J.T. Shepherd, P.M. Vanhoutte), Department of Physiology & Biophysics, Mayo Clinic & Mayo Foundation, Rochester, MN, USA

• Division of Cardiology (Head: Dr. H.P. Krayenbühl), Department of Internal Medicine, Medical Policlinic (Chairman: Dr. W. Siegenthaler), University Hospital Zurich, Switzerland

• Department of Internal Medicine (Chairman: W. Siegenthaler) University Hospital Zurich, Switzerland

C. STAFF POSITIONS • Director of Research, Education and Development, Royal Brompton and Harefield Hospitals

and Consultant of Cardiology (80%; 2017- present)

• Director of the Center for Molecular Cardiology, University of Zurich, Switzerland (20%; 2015 – present)

• Chairman of Cardiology, University Hospital Zurich, Switzerland (1996 – 2017)

D. CLINICAL ACTIVITY • Royal Brompton and Harefield Hospital Trust (2017 – present): Development of research

and education for the entire institution and work as a consultant in general and interventional cardiology with a broad scope of interest.

• University Hospital (1996 – 2017): Responsibility for the Cardiology Service with 11 senior and 21 junior consultants in intervention, rhythmmology, echocardiography, heart failure, coronary care and out-patient service) and 30 fellows, over 30 research fellows, PhDs, administration and nurses.

E. RESEARCH ACTIVITIES

• Applied Basic Research: Role of endothelium-derived mediators in the regulalation of vas-cular tone, platelet-vessel wall interaction, coagulation as well as vascular structure in physio-logicy and hypertension, high LDL- and low HDL-cholesterol and atherosclerosis using cellular and molecular techniques and genetically engineered animal models. More recently, aging and longevity genes have been studied.

• Clinical Research: We aim to translate basic findings on vascular dysfunction in hypertension,

hyperlipidemia, coronary artery disease and congestive heart failure using plethysmography, ultrasound, angiography, IVUS, optical coherence tomography, positron emission tomography and magnetic resonance imaging to the clinical level. Also, nutritional and pharmacological interventions and of devices as well as catheter-based interventions are investigated.

• Registries: The natural disease course is investigated in large registries of acute coronary syn-dromes (SPUM –Registry; n=5’000), the Tako Tsubo Registry (InterTAK Registry; n=2’100) and now the upcoming HEART-ACS registry at the Harefield Hospital.

• Clinical Multicenter Trials: Trials involved endothelial dysfunction in the coronary circulation and its reversal by pharmacotherapy (ENCORE-1 and ENCORE–2) and outcomes of stents (SIRTAX, COMFORTABLE). Further, endothelin antagonists in heart failure (HEAT and EARTH) have been investigated. The effects of the CETP inhibitor dalcetrapib (Dal-VESSEL) and of ezetimibe (PANACEA) and of nutritional products (Pycnogenol, Epicathecin) on

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peripheral and coronary endothelial function have also been studied. A large multicenter trial on the cardiovascular safety of non-steroidal anti-inflammatory drugs has been completed (PRECISION). A first-in-men study with a new stents is currently running (BIO-VITESSE) and a trial on endothelin receptor blockade in Tako Tsubo Syndrome (ICONE Trial) is planned.

Board Memberships and Reviewing of Academic Institutions

2013 – 2019 Chairman of the Board, Cientro Nacional de Investigation de Cardiologia, Madrid

1998 – 2015 Chief Reviewer and Reviewer of the Max-Delbrück-Center, Berlin-Buch, Charité,

Berlin, F.R.G.

1999 Reviewer of the Amsterdam Academic Center, Amsterdam, The Netherlands

1999 Reviewer of the German Ministry for Research, University of Würzburg, F.R.G.

1997 Reviewer of the British Heart Foundation Professorship at University College

London.

2019 Reviewer of the University Heart Center, Mainz University, Mainz, FRG

2019 Reviewer of the Research Programme of the Mainz University, Mainz, FRG

Awards

2019 Andreas-Güntzig-Award and Lecture, Swiss Society of Cardiology, June 13, 2019

2018 Award of the C3 Interventional Academy,Complex Cardiovascular Catheter Therapeutics, Orlando Florida, USA

2018 Werner Forssmann Award, Charité Berlin, FRG 2018 Medal of the Jagiellonian University of Krakow, Poland

2018 Gold Medal of the Serbian Heart Failure Society, Belgrad, Serbia

2017 Paul-Morawitz-Award of the German Society of Cardiology, Mannheim, Germany

2012 Mayo Distinguished Alumni Award. Mayo Clinic, Rocherster, Mn., USA

2008 The Khwarizmi International Award, Islamic Republic of Iran

2007 ESC Andreas Grüntzig Lecture and Silver Medal, European Society of Cardiology.

2001 Björn Folkow Award of the European Society of Hypertension, Milan, Italy

2001 Theodor-Nägeli Award for Thrombosis Research (together with M. Eto)

1994 W.H. Hauss-Preis (together with Barry S. Oemar), German Society for Atherosclerosis Research, Tübingen, Germany

1993 Attilio Reale Prize for Basic Cardiology, Rome, Italy

1993 Mack Forster Award, European Society for Clinical Investigation

1991 Volhard-Prize, German Society of Nephrology, Heidelberg, Germany

1990 Young Investigator Award (1st Prize), 11th World Congress of Cardiology, Manila, Philippines

1990 Research Prize of the Swiss Society of Internal Medicine, Lausanne, Switzerland

1988 Research Prize of the Swiss Society of Cardiology, Bern, Switzerland

Named Lecturerships and Visiting Professorships

1. State-of-the-Art Lecture “History of Modern Cardiology”, CardioEgypt2019, Egyptian Society of Cardiology, Cairo, Egypt, February 28th, 2019.

2. Keynote Lecture «Excel, Explain, Excite», PhD Day 2019 Aarhus University, Denmark, 2019. 3. Keynote Lecture «Managing Acute Coronary Syndromes: From Eisenhowers Heart Attack to the

Future of Cardiology», World Congress of Cardiology, Dubai, U.A.E., December 8th, 2018. 4. Keynote Lecture «Endothelial dysfunction in cardiovascular disease», 8th Biennial Meeting of the

Association for European Cardiovascular Pathology, Lausanne, October 13, 2018. 5. Keynote Lecture «Acute Coronary Syndromes : What we have achieved and what remains to be

done », Great Wall Conference, Beijing, China, October 12, 2018. 6. Keynote Lecture «Personalized Cardiovascular Medicine - this is just a start!», Cardiology

Update, 500 Year Anniversary of the Royal College of Physicians, London, September 13, 2018

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7. Keynote Lecture «A look into the future: Cardiology in 2028», Symposium Innovation in Cardiology, Hotel de Dieu, Beirut, Lebanon, September 7, 2018

8. Keynote Lecture «Frontiers in Acute Coronary Syndromeys : Achievements and Challenges», Complex Cardiovascular Catheter Therapeutics, Orlando Florida, USA, June 18, 2018

9. «What is a normal blood pressure ?», European Society of Cardiology, Barcelona, June 10, 2018 10. Keynote Lecture «Towards a new definition of Tako Tsubo Syndrome», Belgian Acute Cardiac

Care Congress, Brussels, June 7, 2018 11. Werner Forssmann Lecture «The future of cardiovascular medicine», Berlin Heart Academy,2018 12. Keynote Lecture «The best papers in 2017», STEMI Africa, Nairobi, May 5, 2018 13. Keynote Lecture «From Eisenhowers heart attack to modern cardiology», Hopital Universitaire

Genevois, Geneva, Switzerland, March 22, 2018 14. Keynote Lecture. «The heart and the brain», ATHENA 2018, Athens, Greece, March 3, 2018 15. Keynote Lecture. «Inflammation and plaque rupture – from mechanisms to therapeutic targets».

European Society of Clinical Investigation, Genova, Italy, May 17, 2017 16. Keynote Lecture «From Eisenhowers heart attack to modern cardiology», Peruvian Society of

Cardiology, Lima, Peru, April 30, 2017 17. Keynote Lecture. «Aging - the Next Disease? Inborn Molecular Mechanisms of Organ

Dysfunction». 77th National Congress of the Italian Society of Cardiology, Rome, Italy 2016 18. Special Lecture. «Frontiers in Cardiology: Successes, Failures and Perspectives». 80th Annual

Meeting Japanese Circulation Society, Sendai, Japan, 2016 19. Jaap de Graeff Lecture: «From Eisenhower's heart attack to modern cardiology», Leiden

University Medical Center, 2015 20. Sakamoto Lecture. «All the presidents men – a history in case reports», 62nd Meeting of the

Japanese College of Cardiology, Sendai, Japan, 2014 21. 6th Robert L. Krakoff International Lectureship. «From Eisenhower’s heart attack to modern

management of acute coronary syndromes» and «Aging genes and cardiovascular disease», Harvard Medical School Boston, USA, 2014

22. Michael Davies Lecture. «Lipids and lipoproteins in 2012», St. George’s Hospital, London, 2012 23. 13th Arnold L. Johnson Lecture. «From Eisenhower’s heart attack to modern management of

acute coronary syndromes», McMaster University, Hamilton Canada, 2012 24. Lancet Lecture. «No sports!», Cardiology at the Limits, Cape Town, South Africa, 2012. 25. Helmut Drexler Lecture. «Non-lipid genes and atherosclerosis», Cardiology Forum, Rome, 2010 26. Paul M. Vanhoutte Lecture. «The vessel on fire: From endothelial dysfunction to acute coronary

syndromes», 10th International Symposium on Mechanisms of Vasodilation, Japan, 2009

Citation Index Ranking

• Personal citation index 1885 – present: 72’895, h-index = 128 (Fig. 1).

• Most Cited Physiologists in Europe 1996 – 2006, Position Nr. 3 (10'491 Citations in Physiology), Lab-Times 2, 38 – 40, 2008.

• Physiology, German-speaking countries, most cited physiologist (Laborjournal 2006)

• Physiology Research, German-speaking countries 1997 – 1999, Position Nr. 1 (2005)

• Institute for Scientific Information, Philadelphia USA: 0.5% most cited scientists (2002)

• Cardiovascular Research (including cardiology and all related disciplines of basic and clinical research in this area), German-speaking countries 2000 – 2002, Position Nr. 3 (2002)

• Cardiovascular Research (including cardiology and all related disciplines of basic and clinical research in this area), German-speaking countries 1997 – 1999, Position Nr. 1 (2002)

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Fig. 1: Citation index ranking of Prof. Thomas F. Lüscher (with spelling Luscher, Luescher and Lüscher).

Fellowships and Honoray Memberships in Professional Societies

1991 – Present American College of Cardiology

1989 – Present American Heart Association, Council High Blood Pressure Research

1988 – 2000 American Physiological Society (Corresponding Member)

1988 – Present European Society of Cardiology

1988 – 1992 International College of Angiology

2012 – Present Japanese Circulation Society (Honorary Member)

2014 – Present Japanese College of Cardiology (Honorary Member)

2017 - Present Peruvian Society of Cardiology (Honorary Member)

1999 – Present Royal College of Physicians London

Offices in Professional Societies

2018 – present Member, Education Committee, British Cardiovascular Society

2009 – 2021 Chairman Publications Committee, European Society of Cardiology

2004 – 2006 Past-President, Swiss Society of Cardiology

2002 – 2004 President, Swiss Society of Cardiology

2002 – 2004 Vice-President (Working Groups), European Society of Cardiology

2000 – 2002 Vice-President, Swiss Society of Cardiology

2000 – 2002 Chairman, Programme Committee, European Society of Cardiology

1996 – 1998 Chairman, WG Coronary Circulation, European Society of Cardiology

1994 – 1996 President, Swiss Society of Hypertension

1994 – 1996 Counsellor, European Society for Clinical Investigation

F. EDUCATION

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Postgraduate Courses

- Lecturing worldwide for postgraudates and board cetrfified physicians of many disciplines.

- Postgradate Course on Heart Failure 2015 - 2016 and 2016 - 2017, Medical Facutly, University of Zurich, Zurich Heart House, ESC Heart Failure Association and European Society of Cardiology .

- ESC Postgraduate Course Cardiology Update, 1995 - 2019, Davos, Switzerland

- ESC Postgraduate Course Cardiology Update London, 2017 - 2019

- ESC Postgraduate Course London Shock, 2018 - 2019.

- London Postgradate Course on Heart Failure 2019-2020, Royal Brompton & Harefield Hospitals, London, United Kingdom and British Cardiovascular Society

- Cardiology Update Mumbai 2019, Mumbai, India

Textbooks

- ESC Textbook of Cardiovascular Medicine 1st – 3rd Edition, 2003 - 2018 (Oxford University Press),

editor-in-chief (together with John A. Camm, Gerald Maurer and Patrick W. Serruys)

- Module Innere Medizin, Volume 1 - 4 Springer Publishers, Heidelberg, Germany

- Educational Book for Patient (“Das gesunde und das kranke Herz”, EMH, Muttenz, Switzerland)

- CARDIX – Manual of Cardiovascular Medicine (Oxford University Press), in preparation

Past and Present Editor of Scientific Journals

2009 – 2021 Editor-in-Chief, European Heart Journal (Impact Factor: 24.889)

1998 – Present Editor-in-Chief, Cardiovascular Medicine (Swiss Journal of Cardiology)

2004 – 2008 Associate Editor Europe, Circulation

2003 – 2008 Editor, Herz - Cardiovascular Diseases

1992 – 2007 Supplement Editor, Journal of Cardiovascular Pharmacology

1996 – 2000 Associate Editor, Arteriosclerosis, Thrombosis and Vascular Biology

1992 – 1996 Editor Europe, Endothelium - Journal of Endothelial Cell Research

Thomas F. Lüscher 7

II. LIST OF SELECTED PUBLICATIONS

This is a selction of only the more important original research papers as they truly reflect scientific pro-

ductivity. Besides that there is a number of editorials (>200), review articles (>200) and bookchapters

(>100) that are not listed due to space restrictions (see pubmed www.bcbi.nlm.nih.gov)

SELECTED ORIGINAL RESEARCH PUBLICATIONS

OR-1 Macrophage NCOR1 protects from atherosclerosis by repressing a pro-atherogenic PPARγ signature. Oppi S, Nusser-Stein S, Blyszczuk P, Wang X, Jomard A, Marzolla V, Yang K, Velagapudi S, Ward LJ, Yuan XM, Geiger MA, Guillaumon AT, Othman A, Hornemann T, Rancic Z, Ryu D, Oosterveer MH, Osto E, Lüscher TF, Stein S. Eur Heart J. 2019 Sep 16. pii: ehz667.

OR-2 Trimethyllysine, a trimethylamine N-oxide precursor, provides near- and long-term prognostic value in patients presenting with acute coronary syndromes. Li XS, Obeid S, Wang Z, Hazen BJ, Li L, Wu Y, Hurd AG, Gu X, Pratt A, Levison BS, Chung YM, Nissen SE, Tang WHW, Mach F, Räber L, Nanchen D, Matter CM, Lüscher TF, Hazen SL. Eur Heart J. 2019 Aug 21;40(32):2700-2709.

OR-3 Altered limbic and autonomic processing supports brain-heart axis in Takotsubo syndrome. Templin, C., Hänggi, J., Klein, C., Topka, M.S., Hiestand, T., Levinson, R.A., Jurisic, S., Lüscher, T.F., Ghadri, J.-R., Jäncke, L. Eur. Heart J 2019 Apr 14;40(15):1183-1187.

OR-4 Cardiac arrest in takotsubo syndrome: results from the InterTAK Registry. Gili, S., Cammann, V.L., Schlossbauer, S.A., Kato, K., D'Ascenzo, F., Vece, D.D., Jurisic, S., Micek, J., Obeid, S., Bacchi, B., Szawan, K.A., Famos, F., Sarcon, A., Levinson, R., Ding, K.J., Seifert, B., Lenoir, O., Bossone, E., Citro, R., Franke, J., Napp, L.C., Jaguszewski, M., Noutsias, M., Münzel, T., Knorr, M., Heiner, S., Katus, H.A., Burgdorf, C., Schunkert, H., Thiele, H., Bauersachs, J., Tschöpe, C., Pieske, B.M., Rajan, L., Michels, G., Pfister, R., Cuneo, A., Jacobshagen, C., Hasenfuß, G., Karakas, M., Koenig, W., Rottbauer, W., Said, S.M., Braun-Dullaeus, R.C., Banning, A., Cuculi, F., Kobza, R., Fischer, T.A., Vasankari, T., Airaksinen, K.E.J., Opolski, G., Dworakowski, R., MacCarthy, P., Kaiser, C., Osswald, S., Galiuto, L., Crea, F., Dichtl, W., Empen, K., Felix, S.B., Delmas, C., Lairez, O., El-Battrawy, I., Akin, I., Borggrefe, M., Gilyarova, E., Shilova, A., Gilyarov, M., Horowitz, J.D., Kozel, M., Tousek, P., Widimský, P., Winchester, D.E., Ukena, C., Gaita, F., Di Mario, C., Wischnew-sky, M.B., Bax, J.J., Prasad, A., Böhm, M., Ruschitzka, F., Lüscher, T.F., Ghadri, J.R., Templin, C. Eur Heart J 2019 Jul 1;40(26):2142-2151

OR-5 Obesity-induced activation of JunD promotes myocardial lipid accumulation and metabolic cardiomyopathy. Costantino, S., Akhmedov, A., Melina, G., Mohammed, S.A., Othman, A., Ambrosini, S., Wijnen, W.J., Sada, L., Ciavarella, G.M., Liberale, L., Tanner, F.C., Matter, C.M., Hornemann, T., Volpe, M., Mechta-Grigoriou, F., Camici, G.G., Sinatra, R., Lüscher, T.F., Paneni, F. Eur Heart J 2019 Mar 21;40(12):997-1008.

OR-6 AP-1 (Activated Protein-1) Transcription Factor JunD Regulates Ischemia/Reperfusion Brain Damage via IL-1β (Interleukin-1β). Diaz-Cañestro, C., Reiner, M.F., Bonetti, N.R., Liberale, L., Merlini, M., Wüst, P., Amstalden, H., Briand-Schumacher, S., Semerano, A., Giacalone, G., Sessa, M., Beer, J.H., Akhmedov, A., Lüscher, T.F., Camici, G.G. Stroke 2019 Feb;50(2): 469-477.

OR-7 Takotsubo Syndrome Associated With Structural Brain Alterations of the Limbic System. Hiestand T, Hänggi J, Klein C, Topka MS, Jaguszewski M, Ghadri JR, Lüscher TF, Jäncke L, Templin C. J Am Coll Cardiol. 2018 Feb 20;71(7):809-811.

OR-8 Short-Term Outcome After Left Main Interventions in Patients Presenting With Acute Coronary Syndrome. Obeid S, Yousif N, Schelldorfer A, Shahin M, Räber L, Gencer B, Mach F, Roffi M, Matter CM, Windecker S, Lüscher TF. J Invasive Cardiol. 2018 Mar;30(3):98-104.

OR-9 Non-invasive screening for coronary artery disease in asymptomatic diabetic patients: a systematic review and meta-analysis of randomised controlled trials. Clerc OF, Fuchs TA, Stehli J, Benz DC, Gräni C, Messerli M, Giannopoulos AA, Buechel RR, Lüscher TF, Pazhenkottil AP, Kaufmann PA, Gaemperli O. Eur Heart J Cardiovasc Imaging. 2018 Feb 14. doi: 10.1093/ehjci/jey014. [Epub ahead of print]

OR-10 Takotsubo Syndrome Associated With Structural Brain Alterations of the Limbic System.

Thomas F. Lüscher 8

Hiestand T, Hänggi J, Klein C, Topka MS, Jaguszewski M, Ghadri JR, Lüscher TF, Jäncke L, Templin C. J Am Coll Cardiol. 2018 Feb 20;71(7):809-811.

OR-11 Differences in Safety of Non-Steroidal Anti-Inflammatory Drugs in Patients with Osteoarthritis and Rheumatoid Arthritis: A Randomized Clinical Trial. Solomon DH, Husni ME, Wolski KE, Wisniewski LM, Borer JS, Graham DY, Libby P, Lincoff AM, Lüscher TF, Menon V, Yeomans ND, Wang Q, Bao W, Berger MF, Nissen SE; PRECISION Trial Investigators. Arthritis Rheumatol. 2017 Dec 20. doi: 10.1002/art.40400. [Epub ahead of print]

OR-12 Long-term incidence of inappropriate shocks in patients with implantable cardioverter defibril-lators in clinical practice-an underestimated complication? Hofer D, Steffel J, Hürlimann D, Haegeli L, Lüscher TF, Duru F, Eriksson U, Krasniqi N. J Interv Card Electrophysiol. 2017 Dec;50(3):219-226.

OR-13 Cardiac Magnetic Resonance Imaging in Myocarditis Reveals Persistent Disease Activity Despite Normalization of Cardiac Enzymes and Inflammatory Parameters at 3-Month Follow-Up. Berg J, Kottwitz J, Baltensperger N, Kissel CK, Lovrinovic M, Mehra T, Scherff F, Schmied C, Templin C, Lüscher TF, Heidecker B, Manka R. Circ Heart Fail. 2017 Nov;10(11). pii: e004262.

OR-14 Cysteine-rich angiogenic inducer 61 (Cyr61) – a novel soluble biomarker of acute coronary thrombotic occlusion and myocardial ischemia improving risk stratification after acute coro-nary syndromes. Klingenberg L, Aghlmandi S, Liebetrau C, Räber L, Gencer B, Nanchen D, Carballo D, Akhmedov A, Montecucco F, Zoller S, Brokopp C, Heg D, Jüni P, Marti Soler H, Marques-Vidal P-M, Vollenweider P, Doerr O, Rodondi N, Mach F, Windecker S, Land-messer U, von Eckardstein A, Hamm CW, Matter CM, Lüscher TF. Eur. Heart J. 2017; 38:3493-3502.

OR-15 Catecholamine-Dependent β-Adrenergic Signaling in a Pluripotent Stem Cell Model of Takotsubo Cardiomyopathy. Borchert T, Hübscher D, Guessoum CI, Lam TD, Ghadri JR, Schellinger IN, Tiburcy M, Liaw NY, Li Y, Haas J, Sossalla S, Huber MA, Cyganek L, Ja-cobshagen C, Dressel R, Raaz U, Nikolaev VO, Guan K, Thiele H, Meder B, Wollnik B, Zimmermann WH, Lüscher TF, Hasenfuss G, Templin C, Streckfuss-Bömeke K. J Am Coll Cardiol. 2017 Aug 22;70(8):975-991.

OR-16 Gut microbiota-dependent trimethylamine N-oxide in acute coronary syndromes: a prognostic marker for incident cardiovascular events beyond traditional risk factors. Li XS, Obeid S, Klin-genberg R, Gencer B, Mach F, Räber L, Windecker S, Rodondi N, Nanchen D, Muller O, Mi-randa MX, Matter CM, Wu Y, Li L, Wang Z, Alamri HS, Gogonea V, Chung YM, Tang WH, Hazen SL, Lüscher TF. Eur Heart J. 2017;38(11):814-824.

OR-17 Increased proangiogenic activity of mobilized CD34+ progenitor cells of patients with acute ST-segment-elevation myocardial infarction: role of differential micro-RNA-378 expression. Templin C, Volkmann J, Emmert MY, Mocharla P, Müller M, Kraenkel N, Ghadri JR, Meyer M, Styp-Rekowska B, Briand S, Klingenberg R, Jaguszewski M, Matter CM, Djonov V, Mach F, Windecker S, Hoerstrup SP, Thum T, Lüscher TF, Landmesser U. Arterioscler Thromb Vasc Biol. 2017;37(2):341-349.

OR-18 Impact of an optical coherence tomography guided approach in acute coronary syndromes: A propensity matched analysis from the international FORMIDABLE-CARDIOGROUP IV and USZ registry. Iannaccone M, D'Ascenzo F, Frangieh AH, Niccoli G, Ugo F, Boccuzzi G, Bertaina M, Mancone M, Montefusco A, Amabile N, Sardella G, Motreff P, Toutouzas K, Colombo F, Garbo R, Biondi-Zoccai G, Tamburino C, Omedè P, Moretti C, D'amico M, Souteyrand G, Meieir P, Lüscher TF, Gaita F, Templin C. Catheter Cardiovasc Interv. 2017 Aug 1;90(2):E46-E52.

OR-19 A novel clinical score (InterTAK Diagnostic Score) to differentiate Takotsubo syndrome from acute coronary syndrome: results from the International Takotsubo Registry. Ghadri JR, Cammann VL, Jurisic S, Seifert B, Napp LC, Diekmann J, Bataiosu DR, D'Ascenzo F, Ding KJ, Sarcon A, Kazemian E, Birri T, Ruschitzka F, Lüscher TF, Templin C; InterTAK co-investigators. Eur J Heart Fail. 2017 Aug;19(8):1036-1042.

OR-20 Impaired SUMOylation of nuclear receptor LRH-1 promotes nonalcoholic fatty liver disease. Stein S, Lemos V, Xu P, Demagny H, Wang X, Ryu D, Jimenez V, Bosch F, Lüscher TF, Oosterveer MH, Schoonjans K. J Clin Invest. 2017 Feb 1;127(2):583-592.

OR-21 Omega-3 fatty acids predict recurrent venous thromboembolism or total mortality in elderly patients with acute venous thromboembolism. Reiner MF, Stivala S, Limacher A, Bonetti NR, Méan M, Egloff M, Rodondi N, Aujesky D, von Schacky C, Lüscher TF, Camici GG, Beer JH. J Thromb Haemost. 2017 Jan;15(1):47-56.

Thomas F. Lüscher 9

OR-22 Cardiovascular Safety of Celecoxib, Naproxen, or Ibuprofen for Arthritis. Nissen SE, Yeo-mans ND, Solomon DH, Lüscher TF, Libby P, Husni ME, Graham DY, Borer JS, Wisniewski LM, Wolski KE, Wang Q, Menon V, Ruschitzka F, Gaffney M, Beckerman B, Berger MF, Bao W, Lincoff AM; PRECISION Trial Investigators. N Engl J Med. 2016;375 (26):2519-29.

OR-23 Reduced nitric oxide bioavailability mediates cerebroarterial dysfunction independent of cerebral amyloid angiopathy in a mouse model of Alzheimer's disease. Merlini M, Shi Y, Keller S, Savarese G, Akhmedov A, Derungs R, Spescha RD, Kulic L, Nitsch RM, Lüscher TF, Camici GG. Am J Physiol Heart Circ Physiol. 2016; ;312(2):H232-H238.

OR-24 Impact of postdilatation on performance of bioresorbable vascular scaffolds in patients with acute coronary syndrome compared with everolimus-eluting stents: A propensity score-mat-ched analysis from a multicenter "real-world" registry. Imori Y, D'Ascenzo F, Gori T, Münzel T, Fabrizio U, Campo G, Cerrato E, Napp LC, Iannaccone M, Ghadri JR, Kazemian E, Binder RK, Jaguszewski M, Csordas A, Capasso P, Biscaglia S, Conrotto F, Varbella F, Garbo R, Gaita F, Erne P, Lüscher TF, Moretti C, Frangieh AH, Templin C. Cardiol J. 2016;23(4):374-83.

OR-25 Changes in serum biomarker profiles after percutaneous mitral valve repair with the MitraClip system. Yoon JN, Frangieh AH, Attinger-Toller A, Gruner C, Tanner FC, Taramasso M, Corti R, Lüscher TF, Ruschitzka F, Bettex D, Maisano F, Gaemperli O. Cardiol J. 2016;23(4):384-92.

OR-26 Ticagrelor, but not clopidogrel, reduces arterial thrombosis via endothelial tissue factor suppression. Reiner MF, Akhmedov A, Stivala S, Keller S, Gaul DS, Bonetti NR, Savarese G, Glanzmann M, Zhu C, Ruf W, Yang Z, Matter CM, Lüscher TF, Camici GG, Beer JH. Cardiovasc Res. 2017;113(1):61-9.

OR-27 Efficacy and safety of prolonged dual antiplatelet therapy: a meta-analysis of 15 randomized trials enrolling 85 265 patients Savarese G, Savonitto S, Lund LH, Paolillo S, Marciano C, Dellegrottaglie S, Parente A, Trimarco B, Luscher TF, Perrone-Filardi P. Eur Heart J Cardio-vasc Pharmacother. 2016;2(4):218-28.

OR-28 P2Y12 receptor inhibitors in patients with non-ST-elevation acute coronary syndrome in the real world: use, patient selection, and outcomes from contemporary European registries. Zeymer U, Widimsky P, Danchin N, Lettino M, Bardaji A, Barrabes JA, Cequier A, Claeys MJ, De Luca L, Dörler J, Erlinge D, Erne P, Goldstein P, Koul SM, Lemesle G, Lüscher TF, Matter CM, Montalescot G, Radovanovic D, Sendón JL, Tousek P, Weidinger F, Weston CF, Zaman A, Andell P, Li J, Jukema JW; PIRAEUS group. Eur Heart J Cardiovasc Pharmacother. 2016;2(4):229-43.

OR-29 Carbamylated low-density lipoproteins induce a prothrombotic state via LOX-1: impact on arterial thrombus formation in vivo. Holy EW, Akhmedov A, Speer T, Camici GG, Zewinger S, Bonetti N, Beer JH, Lüscher TF, Tanner FC. J Am Coll Cardiol. 2016;68(15):1664-76.

OR-30 ECG criteria to differentiate between Takotsubo (stress) cardiomyopathy and myocardial infarction. Frangieh AH, Obeid S, Ghadri JR, Imori Y, D'Ascenzo F, Kovac M, Ruschitzka F, Lüscher TF, Duru F, Templin C; InterTAK Collaborators. J Am Heart Assoc. 2016 Jun 13;5(6).

OR-31 The electrocardiogram after transcatheter aortic valve replacement determines the risk for post-procedural high-degree AV block and the need for telemetry monitoring. Toggweiler S, Stortecky S, Holy E, Zuk K, Cuculi F, Nietlispach F, Sabti Z, Suciu R, Maier W, Jamshidi P, Maisano F, Windecker S, Kobza R, Wenaweser P, Lüscher TF, Binder RK. JACC Cardio-vasc Interv. 2016;9(12):1269-76.

OR-32 "One-Stop Shop": safety of combining transcatheter aortic valve replacement and left atrial appendage occlusion. Attinger-Toller A, Maisano F, Senn O, Taramasso M, Shakir S, Poss-ner M, Gloekler S, Windecker S, Stortecky S, Lüscher TF, Meier B, Nietlispach F. JACC Cardiovasc Interv. 2016;9(14):1487-95.

OR-33 The MAP kinase JNK2 mediates cigarette smoke-induced arterial thrombosis. Breitenstein A, Stämpfli SF, Reiner MF, Shi Y, Keller S, Akhmedov A, Schaub Clerigué A, Spescha RD, Beer HJ, Lüscher TF, Tanner FC, Camici GG. Thromb Haemost. 2017;117(1):83-9.

OR-34 Unfavorable donor pretransplant APACHE II, SAPS II, and SOFA Scores are not associated with outcome: implications for heart transplant donor selection. Rizzi G, Startseva X, Wol-frum M, Lüscher TF, Ruschitzka F, Fröhlich GM, Enseleit F. Transplant Proc. 2016;48(8) :2582-7.

OR-35 Differences in the clinical profile and outcomes of typical and atypical Takotsubo Syndrome: data from the International Takotsubo Registry. Ghadri JR, Cammann VL, Napp LC, Jurisic S, Diekmann J, Bataiosu DR, Seifert B, Jaguszewski M, Sarcon A, Neumann CA, Geyer V, Prasad A, Bax JJ, Ruschitzka F, Lüscher TF, Templin C; International Takotsubo (InterTAK) Registry. JAMA Cardiol. 2016;1(3):335-40.

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OR-36 Relation of longitudinal changes in quality of life assessments to changes in functional capa-city in patients with heart failure with and without anemia. Cooper TJ, Anker SD, Comin-Colet J, Filippatos G, Lainscak M, Lüscher TF, Mori C, Johnson P, Ponikowski P, Dickstein K. Am J Cardiol. 2016;117(9):1482-7.

OR-37 Meta-analysis of the duration of dual antiplatelet therapy in patients treated with second-generation drug-eluting stents. D'Ascenzo F, Moretti C, Bianco M, Bernardi A, Taha S, Cerrato E, Omedè P, Montefusco A, Frangieh AH, Lee CW, Campo G, Chieffo A, Quadri G, Pavani M, Zoccai GB, Gaita F, Park SJ, Colombo A, Templin C, Lüscher TF, Stone GW. Am J Cardiol. 2016;117(11):1714-23.

OR-38 Decreased phosphatidylcholine plasmalogens--A putative novel lipid signature in patients with stable coronary artery disease and acute myocardial infarction. Sutter I, Klingenberg R, Othman A, Rohrer L, Landmesser U, Heg D, Rodondi N, Mach F, Windecker S, Matter CM, Lüscher TF, von Eckardstein A, Hornemann T. Atherosclerosis. 2016;246:130-40.

OR-39 Changes of coronary plaque composition correlate with C-reactive protein levels in patients with ST-elevation myocardial infarction following high-intensity statin therapy. Koskinas KC, Zaugg S, Yamaji K, García-García HM, Taniwaki M, Klingenberg R, Moschovitis A, Lüscher TF, van Tits LJ, Matter CM, Windecker S, Räber L. Atherosclerosis. 2016;247:154-60.

OR-40 Safety and efficacy profile of bioresorbable-polylactide-polymer-biolimus-A9-eluting stents versus durable-polymer-everolimus- and zotarolimus-eluting stents in patients with acute coronary syndrome. Jaguszewski M, Dörig M, Frangieh AH, Ghadri JR, Cammann VL, Diekmann J, Napp LC, D'Ascenzo F, Imori Y, Obeid S, Maier W, Lüscher TF, Templin C. Catheter Cardiovasc Interv. 2016. [Epub ahead of print]

OR-41 Effect of Bone Marrow-Derived Mononuclear Cell Treatment, Early or Late After Acute Myo-cardial Infarction: Twelve Months CMR and Long-Term Clinical Results. Sürder D, Manka R, Moccetti T, Lo Cicero V, Emmert MY, Klersy C, Soncin S, Turchetto L, Radrizzani M, Zuber M, Windecker S, Moschovitis A, Bühler I, Kozerke S, Erne P, Lüscher TF, Corti R. Circ Res. 2016;119(3):481-90.

OR-42 Prognosis of Patients With Familial Hypercholesterolemia After Acute Coronary Syndromes. Nanchen D, Gencer B, Muller O, Auer R, Aghlmandi S, Heg D, Klingenberg R, Räber L, Car-ballo D, Carballo S, Matter CM, Lüscher TF, Windecker S, Mach F, Rodondi N. Circulation. 2016;134(10):698-709.

OR-43 Dual Antiplatelet Therapy and Outcomes in Patients With Atrial Fibrillation and Acute Coro-nary Syndromes Managed Medically Without Revascularization: Insights From the TRILOGY ACS Trial. Jackson LR 2nd, Piccini JP, Cyr DD, Roe MT, Neely ML, Martinez F, Lüscher TF, Lopes RD, Winters KJ, White HD, Armstrong PW, Fox KA, Prabhakaran D, Bhatt DL, Ohman M E, Corbalán R. Clin Cardiol. 2016;39(9):497-506.

OR-44 Vascular Effects of Eplerenone in Coronary Artery Disease With Preserved Ejection Fraction: A Double-Blind, Randomized, Placebo-Controlled Trial. Sudano I, Naegele M, Roas S, Périat D, Frank M, Kouroedov A, Noll G, Lüscher TF, Enseleit F, Ruschitzka F, Flammer AJ. Clin Cardiol. 2016;39(5):285-90.

OR-45 Plasma ceramides predict cardiovascular death in patients with stable coronary artery di-sease and acute coronary syndromes beyond LDL-cholesterol. Laaksonen R, Ekroos K, Sysi-Aho M, Hilvo M, Vihervaara T, Kauhanen D, Suoniemi M, Hurme R, Marz W, Scharnagl H, Stojakovic T, Vlachopoulou E, Lokki M-L, Nieminen MS, Klingenberg R, Matter CM, Horne-mann T, Juni P, Rodondi N, Raber L, Windecker S, Gencer B, Ringdal Pedersen E, Tell GS, Nygard O, Mach F, Sinisalo J, Luscher TF. Eur Heart J. 2016;37(25):1967-76.

OR-46 Decreased phosphatidylcholine plasmalogens - A putative novel lipid signature in patients with stable coronary artery disease and acute myocardial infarction. Sutter I, Klingenberg R, Othman A, Rohrer L, Landmesser U, Heg D, Rodondi N, Mach F, Windecker S, Matter CM, Lüscher TF, von Eckardstein A, Hornemann T. Atherosclerosis. 2016;6;246:130-40.

OR-47 Prognostic value of PCSK9 levels in patients with acute coronary syndromes. Gencer B, Montecucco F, Nanchen D, Carbone F, Klingenberg R, Vuilleumier N, Aghlmandi S, Heg D, Räber L, Auer R, Jüni P, Windecker S, Lüscher TF, Matter CM, Rodondi N, Mach F. Eur Heart J. 2016;37:546–53.

OR-48 Myocardial expression profiles of candidate molecules in patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia compared to those with dilated cardiomyopathy and healthy controls. Akdis D, Medeiros-Domingo A, Gaertner-Rommel A, Kast JI, Enseleit F, Bode P, Klingel K, Kandolf R, Renois F, Andreoletti L, Akdis CA, Milting H, Lüscher TF, Brunckhorst C, Saguner AM, Duru F. Heart Rhythm. 2016;13(3): 731-41.

OR-49 MicroRNA profiling unveils hyperglycaemic memory in the diabetic heart. Costantino S, Paneni F, Lüscher TF, Cosentino F. Eur Heart J. 2016;37(6):572-6.

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OR-50 Association of left bundle branch block with obstructive coronary artery disease on coronary CT angiography: a case-control study. Clerc OF, Possner M, Maire R, Liga R, Fuchs TA, Stehli J, Vontobel J, Mikulicic F, Gräni C, Benz DC, Lüscher TF, Herzog BA, Buechel RR, Kaufmann PA, Gaemperli O. Eur Heart J Cardiovasc Imaging. 2016;17(7):765-71.

OR-51 Happy heart syndrome: role of positive emotional stress in takotsubo syndrome. Ghadri JR, Sarcon A, Diekmann J, Bataiosu DR, Cammann VL, Jurisic S, Napp LC, Jaguszewski M, Scherff F, Brugger P, Jäncke L, Seifert B, Bax JJ, Ruschitzka F, Lüscher TF, Templin C; InterTAK Co-investigators. Eur Heart J. 2016 Oct 1;37(37):2823-2829.

OR-52 Prevalence and predictors of culprit plaque rupture at OCT in patients with coronary artery disease: a meta-analysis. Iannaccone M, Quadri G, Taha S, D'Ascenzo F, Montefusco A, Omede' P, Jang IK, Niccoli G, Souteyrand G, Yundai C, Toutouzas K, Benedetto S, Barbero U, Annone U, Lonni E, Imori Y, Biondi-Zoccai G, Templin C, Moretti C, Luscher TF, Gaita F. Eur Heart J Cardiovasc Imaging. 2016;17(10):1128-37.

OR-53 Clinical Features and Outcomes of Takotsubo (Stress) Cardiomyopathy. Templin C, Ghadri JR, Diekmann J, Napp LC, Bataiosu DR, Jaguszewski M, Cammann VL, Sarcon A, Geyer V, Neumann CA, Seifert B, Hellermann J, Schwyzer M, Eisenhardt K, Jenewein J, Franke J, Katus HA, Burgdorf C, Schunkert H, Moeller C, Thiele H, Bauersachs J, Tschöpe C, Schul-theiss HP, Laney CA, Rajan L, Michels G, Pfister R, Ukena C, Böhm M, Erbel R, Cuneo A, Kuck KH, Jacobshagen C, Hasenfuss G, Karakas M, Koenig W, Rottbauer W, Said SM, Braun-Dullaeus RC, Cuculi F, Banning A, Fischer TA, Vasankari T, Airaksinen KE, Fijalkow-ski M, Rynkiewicz A, Pawlak M, Opolski G, Dworakowski R, MacCarthy P, Kaiser C, Osswald S, Galiuto L, Crea F, Dichtl W, Franz WM, Empen K, Felix SB, Delmas C, Lairez O, Erne P, Bax JJ, Ford I, Ruschitzka F, Prasad A, Lüscher TF. N Engl J Med. 2015;3;373(10):929-38.

OR-54 Midregional Proadrenomedullin Improves Risk Stratification beyond Surgical Risk Scores in Patients Undergoing Transcatheter Aortic Valve Replacement. Csordas A, Nietlispach F, Schuetz P, Huber A, Müller B, Maisano F, Taramasso M, Moarof I, Obeid S, Stähli BE, Cahenzly M, Binder RK, Liebetrau C, Möllmann H, Kim WK, Hamm C, Lüscher TF. PLoS One. 2015;2;10(12):e0143761.

OR-55 Calcification Characteristics of Low-Flow Low-Gradient Severe Aortic Stenosis in Patients Undergoing Transcatheter Aortic Valve Replacement. Stähli BE, Nguyen-Kim TD, Gebhard C, Frauenfelder T, Tanner FC, Nietlispach F, Maisano F, Falk V, Lüscher TF, Maier W, Bin-der RK. Cardiol Res Pract. 2015:802840.

OR-56 Natural Course of Paravalvular Regurgitation After Implantation of the Self-Expanding Core Valve: Insights From Serial TEE Measurements. Toggweiler S, van Schie B, Zuber M, Sabti Z, Özkartal T, Lüscher TF, Erne P. J Invasive Cardiol. 2015;27(9):435-40.

OR-57 Gender-Related Differences in Patients Presenting with Suspected Acute Coronary Synd-romes: Clinical Presentation, Biomarkers and Diagnosis. Stähli BE, Gebhard C, Yonekawa K, Gebhard CE, Altwegg LA, von Eckardstein A, Hersberger M, Novopashenny I, Wolters R, Wischnewsky MB, Lüscher TF, Maier W. Cardiology. 2015;13;132(3):189-98.

OR-58 Safety of Prasugrel Loading Doses in Patients Pre-Loaded With Clopidogrel in the Setting of Primary Percutaneous Coronary Intervention: Results of a Nonrandomized Observational Study. Räber L, Klingenberg R, Heg D, Kelbæk H, Roffi M, Tüller D, Baumbach A, Zanchin T, Carballo D, Ostojic M, Stefanini GG, Rodondi N, von Birgelen C, Moschovitis A, Engstrøm T, Gencer B, Auer R, Meier B, Mach F, Lüscher TF, Jüni P, Matter CM, Windecker S; COM-FORTABLE and SPUM-ACS Trial Investigators. JACC Cardiovasc Interv. 2015;8(8):1064-74.

OR-59 Prevalence and management of familial hypercholesterolaemia in patients with acute coronary syndromes. Nanchen D, Gencer B, Auer R, Räber L, Stefanini GG, Klingenberg R, Schmied CM, Cornuz J, Muller O, Vogt P, Jüni P, Matter CM, Windecker S, Lüscher TF, Mach F, Rodondi N. Eur Heart J. 2015;21;36(36):2438-45.

OR-60 Circulating FABP4 Is a Prognostic Biomarker in Patients With Acute Coronary Syndrome but Not in Asymptomatic Individuals. Reiser H, Klingenberg R, Hof D, Cooksley-Decasper S, Fuchs N, Akhmedov A, Zoller S, Marques-Vidal P, Marti Soler H, Heg D, Landmesser U, Rodondi N, Mach F, Windecker S, Vollenweider P, Matter CM, Lüscher TF, von Eckardstein A, Gawinecka J. Arterioscler Thromb Vasc Biol. 2015;35(8):1872-9.

OR-61 Post-ischaemic silencing of p66Shc reduces ischaemia/reperfusion brain injury and its ex-pression correlates to clinical outcome in stroke. Spescha RD, Klohs J, Semerano A, Giaca-lone G, Derungs RS, Reiner MF, Rodriguez Gutierrez D, Mendez-Carmona N, Glanzmann M, Savarese G, Kränkel N, Akhmedov A, Keller S, Mocharla P, Kaufmann MR, Wenger RH, Vogel J, Kulic L, Nitsch RM, Beer JH, Peruzzotti-Jametti L, Sessa M, Lüscher TF, Camici GG. Eur Heart J. 2015;1;36(25):1590-600.

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OR-62 Increased prothrombotic profile in the left atrial appendage of atrial fibrillation patients. Brei-tenstein A, Glanzmann M, Falk V, Maisano F, Stämpfli SF, Holy EW, Finlay M, Ling LH, Schilling RJ, Lüscher TF, Steffel J, Camici GG. Int J Cardiol. 2015;15;185:250-5.

OR-63 Safety profile of prasugrel and clopidogrel in patients with acute coronary syndromes in Swi-tzerland. Klingenberg R, Heg D, Räber L, Carballo D, Nanchen D, Gencer B, Auer R, Jagus-zewski M, Stähli BE, Jakob P, Templin C, Stefanini GG, Meier B, Vogt P, Roffi M, Maier W, Landmesser U, Rodondi N, Mach F, Windecker S, Jüni P, Lüscher TF, Matter CM. Heart. 2015;101(11):854-63.

OR-64 Genetic deletion of the adaptor protein p66Shc increases susceptibility to short-term ischae-mic myocardial injury via intracellular salvage pathways. Akhmedov A, Montecucco F, Brau-nersreuther V, Camici GG, Jakob P, Reiner MF, Glanzmann M, Burger F, Paneni F, Galan K, Pelli G, Vuilleumier N, Belin A, Vallée JP, Mach F, Lüscher TF. Eur Heart J. 2015;21;36(8): 516-26.

OR-65 Effect of high-intensity statin therapy on atherosclerosis in non-infarct-related coronary ar-teries (IBIS-4): a serial intravascular ultrasonography study. Räber L, Taniwaki M, Zaugg S, Kelbæk H, Roffi M, Holmvang L, Noble S, Pedrazzini G, Moschovitis A, Lüscher TF, Matter CM, Serruys PW, Jüni P, Garcia-Garcia HM, Windecker S; IBIS 4 (Integrated Biomarkers and Imaging Study-4) Trial Investigators (NCT00962416). Eur Heart J. 2015;21;36(8): 490-500.

OR-66 Outcome of super-responders to cardiac resynchronization therapy defined by endpoint-de-rived parameters of left ventricular remodeling: a two-center retrospective study. Hürlimann D, Schmidt S, Seifert B, Saguner AM, Hindricks G, Lüscher TF, Ruschitzka F, Steffel J. Clin Res Cardiol. 2015;104(2):136-44.

OR-67 Feasibility of second-generation bioresorbable vascular scaffold implantation in complex ana-tomical and clinical scenarios. Jaguszewski M, Ghadri JR, Zipponi M, Bataiosu DR, Diek-mann J, Geyer V, Neumann CA, Huber MA, Hagl C, Erne P, Lüscher TF, Templin C. Clin Res Cardiol. 2015;104(2):124-35.

OR-68 Expected impact of applying new 2013 AHA/ACC cholesterol guidelines criteria on the re-commended lipid target achievement after acute coronary syndromes. Gencer B, Auer R, Nanchen D, Räber L, Klingenberg R, Carballo D, Blum M, Vogt P, Carballo S, Meyer P, Ma-tter CM, Windecker S, Lüscher TF, Mach F, Rodondi N. Atherosclerosis. 2015;239(1):118-24.

OR-69 Adverse epigenetic signatures by histone methyltransferase set7 contribute to vascular dys-function in patients with type 2 diabetes mellitus. Paneni F, Costantino S, Battista R, Castello L, Capretti G, Chiandotto S, Scavone G, Villano A, Pitocco D, Lanza G, Volpe M, Lüscher TF, Cosentino F. Circ Cardiovasc Genet. 2015;8(1):150-8.

OR-70 The impact of intravenous ferric carboxymaltose on renal function: an analysis of the FAIR-HF study. Ponikowski P, Filippatos G, Colet JC, Willenheimer R, Dickstein K, Lüscher T, Gaudesius G, von Eisenhart Rothe B, Mori C, Greenlaw N, Ford I, Macdougall I, Anker SD; for the FAIR-HF Trial Investigators. Eur J Heart Fail. 2015;17(3):329-39.

OR-71 Rapid and Body Weight-Independent Improvement of Endothelial and High-Density Lipopro-tein Function After Roux-en-Y Gastric Bypass: Role of Glucagon-Like Peptide-1. Osto E, Doytcheva P, Corteville C, Bueter M, Dörig C, Stivala S, Buhmann H, Colin S, Rohrer L, Hasballa R, Tailleux A, Wolfrum C, Tona F, Manz J, Vetter D, Spliethoff K, Vanhoutte PM, Landmesser U, Pattou F, Staels B, Matter CM, Lutz TA, Lüscher TF. Circulation. 2015;10; 131(10):871-81.

OR-72 Dietary omega-3 alpha-linolenic acid does not prevent venous thrombosis in mice. Reiner MF, Martinod K, Stivala S, Savarese G, Camici GG, Lüscher TF, Wagner DD, Beer JH. Thromb Haemost. 2015;113(1):177-84.

OR-73 Anacetrapib reduces progression of atherosclerosis, mainly by reducing non-HDL-choles-terol, improves lesion stability and adds to the beneficial effects of atorvastatin. Kühnast S, van der Tuin SJ, van der Hoorn JW, van Klinken JB, Simic B, Pieterman E, Havekes LM, Landmesser U, Lüscher TF, Willems van Dijk K, Rensen PC, Jukema JW, Princen HM. Eur Heart J. 2015;1;36(1):39-48.

OR-74 Genetic deletion of the adaptor protein p66Shc increases susceptibility to short-term ischaemic myocardial injury via intracellular salvage pathways Akhmedov A., Montecucco F, Brauners-reuther V, Camici GG, Jacob, Reiner MF, Glanzmann M, Burger F, Paneni F, Galan K, Pelli G, Vuilleumier N, Belin A, Vallée J-P, Mach F, Lüscher TF. Eur Heart J. 2015;36: 516-26.

OR-75 N-terminal pro-B-type natriuretic peptide-ratio predicts mortality after transcatheter aortic valve replacement. Stähli BE, Gebhard C, Saleh L, Falk V, Landmesser U, Nietlispach F, Maisano F, Lüscher TF, Maier W, Binder RK.Catheter Cardiovasc Interv. 2015;85(7):1240-7.

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OR-76 Targeting prolyl-isomerase Pin1 prevents mitochondrial oxidative stress and vascular dys-function: insights in patients with diabetes. Paneni F, Costantino S, Castello L, Battista R, Capretti G, Chiandotto S, D'Amario D, Scavone G, Villano A, Rustighi A, Crea F, Pitocco D, Lanza G, Volpe M, Del Sal G, Lüscher TF, Cosentino F. Eur Heart J. 2015;36(13):817-28.

OR-77 Enhanced age-dependent cerebrovascular dysfunction is mediated by adaptor protein p66Shc. Shi Y, Savarese G, Perrone-Filardi P, Lüscher TF, Camici GG. Int J Cardiol. 2014; 20;175(3):446-50.

OR-78 Drug-eluting stents vs. bare metal stents in patients with cardiogenic shock: a comparison by propensity score analysis. Jaguszewski M, Ghadri JR, Seifert B, Hiestand T, Herrera P, Gaemperli O, Landmesser U, Maier W, Nallamothu BK, Windecker S, Lüscher TF, Templin C. J Cardiovasc Med (Hagerstown). 2015;16(3):220-9.

OR-79 Clonal restriction and predominance of regulatory T cells in coronary thrombi of patients with acute coronary syndromes. Klingenberg R, Brokopp CE, Grivès A, Courtier A, Jaguszewski M, Pasqual N, Vlaskou Badra E, Lewandowski A, Gaemperli O, Hoerstrup SP, Maier W, Landmesser U, Lüscher TF, Matter CM. Eur Heart J. 2015;36(17):1041-8.

OR-80 Epigenetic regulation of tissue factor inducibility in endothelial cell senescence. Kurz DJ, Payeli S, Greutert H, Briand Schumacher S, Lüscher TF, Tanner FC. Mech Ageing Dev. 2014;140:1-9.

OR-81 High-density lipoprotein from patients with coronary heart disease loses anti-thrombotic ef-fects on endothelial cells: impact on arterial thrombus formation. Holy EW, Besler C, Reiner MF, Camici GG, Manz J, Beer JH, Lüscher TF, Landmesser U, Tanner FC. Thromb Haemost. 2014;112(5):1024-35.

OR-82 Clinical criteria replenish high-sensitive troponin and inflammatory markers in the stratification of patients with suspected acute coronary syndrome. Stähli BE, Yonekawa K, Altwegg LA, Wyss C, Hof D, Fischbacher P, Brauchlin A, Schulthess G, Krayenbühl PA, von Eckardstein A, Hersberger M, Neidhart M, Gay S, Novopashenny I, Wolters R, Frank M, Wischnewsky MB, Lüscher TF, Maier W. PLoS One. 2014;3;9(6):e98626.

OR-83 The MI SYNTAX score for risk stratification in patients undergoing primary percutaneous coronary intervention for treatment of acute myocardial infarction: a substudy of the COM-FORTABLE AMI trial. Magro M, Raber L, Heg D, Taniwaki M, Kelbaek H, Ostojić M, Baum-bach A, Tüller D, von Birgelen C, Roffi M, Pedrazzini G, Kornowski R, Weber K, Meier B, Lüscher TF, Serruys PW, Jüni P, Windecker S. Int J Cardiol. 2014;175(2):314-22.

OR-84 Alternatively spliced tissue factor is not sufficient for embryonic development. Sluka SH, Akhmedov A, Vogel J, Unruh D, Bogdanov VY, Camici GG, Lüscher TF, Ruf W, Tanner FC. PLoS One. 2014;30;9(5):e97793.

OR-85 Percutaneous mitral valve edge-to-edge repair: in-hospital results and 1-year follow-up of 628 patients of the 2011-2012 Pilot European Sentinel Registry. Nickenig G, Estevez-Loureiro R, Franzen O, Tamburino C, Vanderheyden M, Lüscher TF, Moat N, Price S, Dall'Ara G, Winter R, Corti R, Grasso C, Snow TM, Jeger R, Blankenberg S, Settergren M, Tiroch K, Balzer J, Petronio AS, Büttner HJ, Ettori F, Sievert H, Fiorino MG, Claeys M, Ussia GP, Baumgartner H, Scandura S, Alamgir F, Keshavarzi F, Colombo A, Maisano F, Ebelt H, Aruta P, Lubos E, Plicht B, Schueler R, Pighi M, Di Mario C; Transcatheter Valve Treatment Sentinel Registry Investigators of the EURObservational Research Programme of the European Society of Cardiology. J Am Coll Cardiol. 2014;2;64(9):875-84.

OR-86 A PET/CT-follow-up imaging study to differentiate takotsubo cardiomyopathy from acute myocardial infarction. Ghadri JR, Dougoud S, Maier W, Kaufmann PA, Gaemperli O, Prasad A, Lüscher TF, Templin C. Int J Cardiovasc Imaging. 2014;30(1):207-9.

OR-87 Endothelial overexpression of LOX-1 increases plaque formation and promotes atheroscle-rosis in vivo. Akhmedov A, Rozenberg I, Paneni F, Camici GG, Shi Y, Doerries C, Sledzinska A, Mocharla P, Breitenstein A, Lohmann C, Stein S, von Lukowicz T, Kurrer MO, Borén J, Be-cher B, Tanner FC, Landmesser U, Matter CM, Lüscher TF. Eur Heart J. 2014;35(40):2839-48.

OR-88 Biolimus-eluting stents with biodegradable polymer versus bare-metal stents in acute myo-cardial infarction: two-year clinical results of the COMFORTABLE AMI trial. Räber L, Kelbæk H, Taniwaki M, Ostojic M, Heg D, Baumbach A, von Birgelen C, Roffi M, Tüller D, Engstrøm T, Moschovitis A, Pedrazzini G, Wenaweser P, Kornowski R, Weber K, Lüscher TF, Matter CM, Meier B, Jüni P, Windecker S; COMFORTABLE AMI Trial Investigators. Circ Cardiovasc Interv. 2014;7(3):355-64.

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OR-89 Transcatheter aortic valve-in-valve implantation: clinical outcome as defined by VARC-2 and postprocedural valve dysfunction according to the primary mode of bioprosthesis failure. Stähli BE, Reinthaler M, Nguyen-Kim TD, Gebhard C, Tasnady H, Grünenfelder J, Falk V, Corti R, Frauenfelder T, Lüscher TF, Maier W, Mullen MJ, Landmesser U. J Invasive Cardiol. 2014;26(10):542-7.

OR-90 Dual role of endothelial nitric oxide synthase in oxidized LDL-induced, p66Shc-mediated oxidative stress in cultured human endothelial cells. Shi Y, Lüscher TF, Camici GG. PLoS One. 2014;23;9(9):e107787.

OR-91 The impact of modern noninvasive cardiac imaging on coronary intervention rates. Fröhlich GM, Schoch B, Wolfrum M, Osranek M, Enseleit F, Herzog BA, Hasun M, Lüscher TF, Meier P, Gaemperli O, Kaufmann PA, Corti R. J Interv Cardiol. 2014;27(1):50-7.

OR-92 Adaptor protein p66(Shc) mediates hypertension-associated, cyclic stretch-dependent, endo-thelial damage. Spescha RD, Glanzmann M, Simic B, Witassek F, Keller S, Akhmedov A, Tanner FC, Lüscher TF, Camici GG. Hypertension. 2014;64(2):347-53.

OR-93 Treatment with higher dosages of heart failure medication is associated with improved out-come following cardiac resynchronization therapy. Schmidt S, Hürlimann D, Starck CT, Hindricks G, Lüscher TF, Ruschitzka F, Steffel J. Eur Heart J. 2014;35(16):1051-60.

OR-94 PI3K/p110α inhibition selectively interferes with arterial thrombosis and neointima formation, but not re-endothelialization: potential implications for drug-eluting stent design. Holy EW, Jakob P, Eickner T, Camici GG, Beer JH, Akhmedov A, Sternberg K, Schmitz KP, Lüscher TF, Tanner FC. Eur Heart J. 2014;35(12):808-20.

OR-95 A PET/CT-follow-up imaging study to differentiate takotsubo cardiomyopathy from acute myo-cardial infarction. Ghadri JR, Dougoud S, Maier W, Kaufmann PA, Gaemperli O, Prasad A, Lüscher TF, Templin C. Int J Cardiovasc Imaging. 2014;30(1):207-9.

OR-96 Effects of the high-density lipoprotein mimetic agent CER-001 on coronary atherosclerosis in patients with acute coronary syndromes: a randomized trial. Tardif JC, Ballantyne CM, Barter P, Dasseux JL, Fayad ZA, Guertin MC, Kastelein JJ, Keyserling C, Klepp H, Koenig W, L'Al-lier PL, Lespérance J, Lüscher TF, Paolini JF, Tawakol A, Waters DD; Can HDL Infusions Significantly QUicken Atherosclerosis REgression (CHI-SQUARE) Investigators. Eur Heart J. 2014;7;35(46):3277-86

OR-97 Continuing medical education activity in echocardiography. Fan P, Stähli BE, Abouelnour A, Nguyen TD, Vecchiati A, Maier W, Lüscher TF, Frauenfelder T, Tanner FC. Echocardio-graphy. 2014;31(8):1005.

OR-98 Essential role of sympathetic endothelin A receptors for adverse cardiac remodeling. Leh-mann LH, Rostosky JS, Buss SJ, Kreusser MM, Krebs J, Mier W, Enseleit F, Spiger K, Hardt SE, Wieland T, Haass M, Lüscher TF, Schneider MD, Parlato R, Gröne HJ, Haberkorn U, Yanagisawa M, Katus HA, Backs J. Proc Natl Acad Sci U S A. 2014;16;111(37):13499-504.

OR-99 Recovery mismatch between myocardial blood flow and cardiac workload after physical exercise: a positron emission tomography study. Siegrist PT, Koepfli P, Namdar M, Pazh-enkottil AP, Nkoulou R, Lüscher TF, Kaufmann PA. Eur Heart J Cardiovasc Imaging. 2014;15 (12):1386-90.

OR-100 Restraint stress enhances arterial thrombosis in vivo - role of the sympathetic nervous system. Stämpfli SF, Camici GG, Keller S, Rozenberg I, Arras M, Schuler B, Gassmann M, Garcia I, Lüscher TF, Tanner FC. Stress. 2014;17(1):126-32.

OR-101 A signature of circulating microRNAs differentiates takotsubo cardiomyopathy from acute myocardial infarction. Jaguszewski M, Osipova J, Ghadri JR, Napp LC, Widera C, Franke J, Fijalkowski M, Nowak R, Fijalkowska M, Volkmann I, Katus HA, Wollert KC, Bauersachs J, Erne P, Lüscher TF, Thum T, Templin C. Eur Heart J. 2014;35(15):999-1006.

OR-102 Comprehensive cardiac resynchronization therapy (CRT) optimization in the real world. Steffel J, Rempel H, Breitenstein A, Schmidt S, Namdar M, Krasniqi N, Holzmeister J, Lüscher TF, Ruschitzka F, Hürlimann D. Cardiol J. 2014;21(3):316-24.

OR-103 Usefulness of electrocardiographic parameters for risk prediction in arrhythmogenic right ventricular dysplasia. Saguner AM, Ganahl S, Baldinger SH, Kraus A, Medeiros-Domingo A, Nordbeck S, Saguner AR, Mueller-Burri AS, Haegeli LM, Wolber T, Steffel J, Krasniqi N, Delacrétaz E, Lüscher TF, Held L, Brunckhorst CB, Duru F. Am J Cardiol. 2014;15;113(10): 1728-34.

OR-104 Rehabilitation after TAVI compared to surgical aortic valve replacement. Fauchère I, Weber D, Maier W, Altwegg L, Lüscher TF, Grünenfelder J, Nowak A, Tüller D, Genoni M, Falk V, Hermann M. Int J Cardiol. 2014;15;173(3): 564-6.

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OR-105 Quality of care after acute coronary syndromes in a prospective cohort with reasons for non-prescription of recommended medications. Auer R, Gencer B, Räber L, Klingenberg R, Carballo S, Carballo D, Nanchen D, Cornuz J, Vader JP, Vogt P, Jüni P, Matter CM, Windecker S, Lüscher TF, Mach F, Rodondi N. PLoS One. 2014;27;9(3):e93147.

OR-106 Carbamylated low-density lipoprotein induces endothelial dysfunction. Speer T, Owala FO, Holy EW, Zewinger S, Frenzel FL, Stähli BE, Razavi M, Triem S, Cvija H, Rohrer L, Seiler S, Heine GH, Jankowski V, Jankowski J, Camici GG, Akhmedov A, Fliser D, Lüscher TF, Tanner FC. Eur Heart J. 2014;14;35(43):3021-32.

OR-107 The Sirt1 activator SRT3025 provides atheroprotection in Apoe-/- mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression. Miranda MX, van Tits LJ, Lohmann C, Arsiwala T, Winnik S, Tailleux A, Stein S, Gomes AP, Suri V, Ellis JL, Lutz TA, Hottiger MO, Sinclair DA, Auwerx J, Schoonjans K, Staels B, Lüscher TF, Matter CM. Eur Heart J. 2015;1;36(1):51-9.

OR-108 Disease progress in patients with Morbus Fabry after switching from agalsidase beta to agalsidase alpha. Reidt S, Namdar M, Serra A, Krayenbühl PA, Gruner C, Keller DI, Lüscher TF, Schmied C. Intern Med J. 2014;44(2):205-7.

OR-109 First three-dimensional optical frequency domain imaging evaluation of a bioabsorbable vascular scaffold implantation in an instent-restenosis 6 years after CYPHER stenting. Jaguszewski M, Obeid S, Lüscher TF, Templin C. Eur Heart J. 2014;1;35(21):1393.

OR-110 Acute multivessel revascularization improves 1-year outcome in ST-elevation myocardial infarction: a nationwide study cohort from the AMIS Plus registry. Jeger R, Jaguszewski M, Nallamothu BN, Lüscher TF, Urban P, Pedrazzini GB, Erne P, Radovanovic D; AMIS Plus Investigators. Int J Cardiol. 2014;1;172(1):76-81.

OR-111 Different prognostic value of functional right ventricular parameters in arrhythmogenic right ventricular cardiomyopathy/dysplasia. Saguner AM, Vecchiati A, Baldinger SH, Rüeger S, Medeiros-Domingo A, Mueller-Burri AS, Haegeli LM, Biaggi P, Manka R, Lüscher TF, Fon-taine G, Delacrétaz E, Jenni R, Held L, Brunckhorst C, Duru F, Tanner FC. Circ Cardiovasc Imaging. 2014;1;7(2):230-9.

OR-112 Deletion of Sirt3 does not affect atherosclerosis but accelerates weight gain and impairs rapid metabolic adaptation in LDL receptor knockout mice: implications for cardiovascular risk fac- tor development. Winnik S, Gaul DS, Preitner F, Lohmann C, Weber J, Miranda MX, Liu Y, van Tits LJ, Mateos JM, Brokopp CE, Auwerx J, Thorens B, Lüscher TF, Matter CM. Basic Res Cardiol. 2014;109(1):399.

OR-113 Altered activation of endothelial anti- and proapoptotic pathways by high-density lipoprotein from patients with coronary artery disease: role of high-density lipoprotein-proteome remod-eling. Riwanto M, Rohrer L, Roschitzki B, Besler C, Mocharla P, Mueller M, Perisa D, Hein-rich K, Altwegg L, von Eckardstein A, Lüscher TF, Landmesser U. Circulation. 2013;127(8): 891-904.

OR-114 Abnormal high-density lipoprotein induces endothelial dysfunction via activation of Toll-like receptor-2. T. Speer, L. Rohrer, P. Blyszczuk, R. Shroff, K. Kuschnerus, N. Kränkel, G. Ka-nia, S. Zewinger, A. Akhmedov, Y. Shi, T. Martin, D. Perisa, S. Winnik, M.F. Müller, U. Ses-ter, G. Wernicke, A. Jung, U. Gutteck, U. Eriksson, J. Geisel, J. Deanfield, A. von Eckard-stein, T.F. Lüscher, D. Fliser, F.H. Bahlmann, U. Landmesser. Immunity. 2013;38(4):754-68.

OR-115 Intracoronary injection of bone marrow-derived mononuclear cells early or late after acute myocardial infarction: effects on global left ventricular function. D. Sürder, R. Manka, V. Lo Cicero, T. Moccetti, K. Rufibach, S. Soncin, L. Turchetto, M. Radrizzani, G. Astori, J. Schwi-tter, P. Erne, M. Zuber, C. Auf der Maur, P. Jamshidi, O. Gaemperli, S. Windecker, A. Mosch-ovitis, A. Wahl, I. Bühler, C. Wyss, S. Kozerke, U. Landmesser, T.F. Lüscher, R. Corti. Circulation. 2013;14;127(19):1968-79.

OR-116 Endothelial mineralocorticoid receptor activation mediates endothelial dysfunction in diet-induced obesity. N. Schäfer, C. Lohmann, S. Winnik, L.J. van Tits, M.X. Miranda, A. Vergo-poulos, F. Ruschitzka, J. Nussberger, S. Berger, T.F. Lüscher, F. Verrey, C.M. Matter. Eur Heart J. 2013;34(45):3515-24.

OR-117 Novel insights into the critical role of bradykinin and the kinin b2 receptor for vascular recruit-tment of circulating endothelial repair-promoting mononuclear cell subsets: alterations in patients with coronary disease. N. Kränkel, K. Kuschnerus, M. Müller, T. Speer, P. Mocharla, P. Madeddu, M. Bader, T.F. Lüscher, U. Landmesser. Circulation. 2013;127(5):594-603.

OR-118 Depletion of FOXP3+ regulatory T cells promotes hypercholesterolemia and atherosclerosis. R. Klingenberg, N. Gerdes, R.M. Badeau, A. Gisterå, D. Strodthoff, D.F. Ketelhuth, A.M. Lundberg, M. Rudling, S.K. Nilsson, G. Olivecrona, S. Zoller, C. Lohmann, T.F. Lüscher, M. Jauhiainen, T. Sparwasser, G.K. Hansson. J Clin Invest. 2013;123(3):1323-34.

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OR-119 The value of coronary calcium score in daily clinical routine, a case series of patients with extensive coronary calcifications. J.R. Ghadri, M. Fiechter, T.A. Fuchs, C. Templin, T.F. Lüscher, P.A. Kaufmann. Int J Cardiol. 2013;162(2):e47-9.

OR-120 Real-time left ventricular pressure-volume loops during percutaneous mitral valve repair with the MitraClip system. O. Gaemperli, P. Biaggi, R. Gugelmann, M. Osranek, J.J. Schreuder, I. Bühler, D. Sürder, T.F. Lüscher, C. Felix, D. Bettex, J. Grünenfelder, R. Corti. Circulation. 2013;127(9):1018-27.

OR-121 Haemodynamically irrelevant pericardial effusion is associated with increased mortality in patients with chronic heart failure. G.M. Fröhlich, P. Keller, F. Schmid, M. Wolfrum, M. Osranek, C. Falk, G. Noll, F. Enseleit, M. Reinthaler, P. Meier, T.F. Lüscher, F. Ruschitzka, F.C. Tanner. Eur Heart J. 2013;34(19):1414-23.

OR-122 Mechanical versus manual chest compression CPR under ground ambulance transport con-ditions. J. Fox, R. Fiechter, P. Gerstl, A. Url, H. Wagner, T.F. Lüscher, U. Eriksson, C.A. Wyss. Acute Card Care. 2013;15(1):1-6.

OR-123 The effect of intravenous ferric carboxymaltose on health-related quality of life in patients with chronic heart failure and iron deficiency: a subanalysis of the FAIR-HF study. J. Comin-Colet, M. Lainscak, K. Dickstein, G.S. Filippatos, P. Johnson, T.F. Lüscher, C. Mori, R. Willenhei-mer, P. Ponikowski, S.D. Anker. Eur Heart J. 2013; 34(1):30-8.

OR-124 Deletion of the activated protein-1 transcription factor JunD induces oxidative stress and ac-celerates age-related endothelial dysfunction. F. Paneni, E. Osto, S. Costantino, B. Mate-escu, S. Briand, G. Coppolino, E. Perna, P. Mocharla, A. Akhmedov, R. Kubant, L. Rohrer, T. Malinski, G.G. Camici, C.M. Matter, F. Mechta-Grigoriou, M. Volpe, T.F. Lüscher, F. Cosen-tino. Circulation. 2013;127(11):1229-40.

OR-125 Vascular lesions induced by renal nerve ablation as assessed by optical coherence tomogra-phy: pre- and post-procedural comparison with the Simplicity® catheter system and the Enlig HTN™ multi-electrode renal denervation catheter. C. Templin, M. Jaguszewski, J. R. Ghadri, I. Sudano, R. Gaehwiler, J. P. Hellermann, R. Schoenenberger-Berzins, U. Landmesser, P. Erne, G. Noll, T. F. Lüscher. Eur Heart J. 2013;34(28):2141–8.

OR-126 Peripheral blood monocyte Sirt1 expression Is reduced in patients with coronary artery dis-ease. A. Breitenstein, C. A. Wyss, R. D. Spescha, F. C. Franzeck, D. Hof, M. Riwanto, M. Hasun, A. Akhmedov, A. von Eckardstein, W. Maier, U. Landmesser, T. F. Lüscher, G. G. Camici. PLoS One. 2013;8(1):e53106.

OR-127 AngiomiR-126 expression and secretion from circulating CD34+ and CD14+ PBMCs: role for pro-angiogenic effects and alterations in type-2 diabetics. P. Mocharla, S. Briand, G. Gianno-tti, C. Dörries, P. Jakob, F. Paneni, T. F. Lüscher, U. Landmesser. Blood. 2013;121:226-36.

OR-128 Deletion of the ageing gene p66Shc reduces early stroke size following ischaemia/reperfusion brain injury. R.D. Spescha, Y. Shi, S. Wegener, S. Keller, B. Weber, M.M. Wyss, N. Lauinger, G. Tabatabai, F. Paneni, F. Cosentino, C. Hock, M. Weller, R.M. Nitsch, T.F. Lüscher, G.G. Camici. Eur. Heart J. 2013;34:96-103.

OR-129 Cardiac hybrid imaging guides revascularization prior to non-cardiac surgery. J.R. Ghadri, T.A. Fuchs, C. Templin, T.F. Lüscher, W. Maier, P.A. Kaufmann. Int J Cardiol. 2013;163: e44-e46.

OR-130 Nitric oxide synthase 2 is required for conversion of pro-fibrogenic inflammatory CD133+ pro-genitors into F4/80+ macrophages in experimental autoimmune myocarditis. P. Blyszczuk, C. Berthonneche, S. Behnke, M. Glönkler, H. Moch, T. Pedrazzini, T.F. Lüscher, U. Eriksson, G. Kania. Cardiovasc Res. 2013;97:219-29.

OR-131 Usefulness of inducible ventricular tachycardia to predict long-term adverse outcomes in ar-rhythmogenic right ventricular cardiomyopathy. A.M. Saguner, A. Medeiros-Domingo, M.A. Schwyzer, C.J. On, L.M. Haegeli, T. Wolber, D. Hürlimann, J. Steffel, N. Krasniqi, S. Rüeger, L. Held, T.F. Lüscher, C. Brunckhorst, F. Duru. Am J Cardiol. 2013;111: 250-7.

OR-132 Registry for the evaluation of the PROgnostic value of a novel integrated imaging approach combining Single Photon Emission Computed Tomography with coronary calcification ima-ging (REPROSPECT). J.R. Ghadri, M. Fiechter, T.A. Fuchs, A. Scherrer, J. Stehli, C. Geb-hard, B. Kläser, O. Gaemperli, T.F. Lüscher, C. Templin, P.A. Kaufmann. Eur. Heart J. Cardiovasc. Imaging 2013;14:374-380.

OR-133 Loss of AngiomiR-126 and 130a in angiogenic early outgrowth cells from patients with chro-nic heart failure: Role for impaired in vivo neovascularization and cardiac repair capacity. P. Jakob, C. Doerries, S. Briand, P. Mocharla, N. Kränkel, C. Besler, M. Mueller, C. Manes, C. Templin, C. Baltes, M. Rudin, H. Adams, M. Wolfrum, G. Noll, F. Ruschitzka, T. F. Lüscher, U. Landmesser. Circulation. 2012;126:2962-75.

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OR-134 Predictors of appropriate ICD Therapy in patients with arrhythmogenic right ventricular car-diomyopathy, Long term experience of a tertiary care center. P.K. Schuler, L.M. Haegeli, A.M. Saguner, T. Wolber, F.C. Tanner, R. Jenni, N. Corti, T.F. Lüscher, C. Brunckhorst, F. Duru. PLoS One. 2012;7:e39584.

OR-135 Association between inflammatory and obesity markers in a Swiss population-based sample (CoLaus Study). P. Marques-Vidal, M. Bochud, F. Bastardot, T. F. Lüscher, F. Ferrero, J.M. Gaspoz, F. Paccaud, A. Urwyler, R. von Känel, C. Hock, G. Waeber, M. Preisig, P. Vollen-weider. Obes Facts. 2012;5:734-44.

OR-136 Dronedarone reduces arterial thrombus formation. A. Breitenstein, S.H. Sluka, A. Akhmedov, S. Stivala, J. Steffel, G.G. Camici, H.H. Riem, H.J. Beer, S.D. Studt, F. Duru, T.F. Luscher, F.C. Tanner. Basic Res Cardiol. 2012;107: 302.

OR-137 Effect of biolimus-eluting stents with biodegradable polymer vs bare-metal stents on cardio-vascular events among patients with acute myocardial infarction: the COMFORTABLE AMI randomized trial. L. Räber, H. Kelbæk, M. Ostojic, A. Baumbach, D. Heg, D. Tüller, C. von Birgelen, M. Roffi, A. Moschovitis, A.A. Khattab, P. Wenaweser, R. Bonvini, G. Pedrazzini, R. Kornowski, K. Weber, S. Trelle, T.F. Lüscher, M. Taniwaki, C.M. Matter, B. Meier, P. Jüni, S. Windecker; COMFORTABLE AMI Trial Investigators. JAMA. 2012;308:777-87.

OR-138 Torcetrapib impairs endothelial function in hypertension. B. Simic, M. Hermann, S.G. Shaw, L. Bigler, U. Stalder, C. Dörries, C. Besler, T.F. Lüscher, F. Ruschitzka. Eur Heart J. 2012; 33:1615-24.

OR-139 Gene silencing of the mitochondrial adaptor p66(Shc) suppresses vascular hyperglycemic memory in diabetes. F. Paneni, P. Mocharla, A. Akhmedov, S. Costantino, E. Osto, M. Volpe, T.F. Lüscher, F. Cosentino. Circ Res. 2012;111:278-89.

OR-140 Vascular effects and safety of dalcetrapib in patients with or at risk of coronary heart disease: the dal-VESSEL randomized clinical trial. T.F. Lüscher, S. Taddei, J.C. Kaski, J.W. Jukema, D. Kallend, T. Münzel, J.J. Kastelein, J.E. Deanfield; dal-VESSEL Investigators. Eur Heart J. 2012;33:857-65.

OR-141 Comparison of drug-eluting stents with bare metal stents in patients with ST-segment ele-vation myocardial infarction. B. Kalesan, T. Pilgrim, K. Heinimann, L. Räber, G.G. Stefanini, M. Valgimigli, B.R. da Costa, F. Mach, T.F. Lüscher, B. Meier, S. Windecker, P. Jüni. Eur Heart J. 2012;33:977-87.

OR-142 Acute haemodynamic changes after percutaneous mitral valve repair: relation to mid-term outcomes. O. Gaemperli, M. Moccetti, D. Surder, P. Biaggi, D. Hurlimann, O. Kretschmar, I. Buehler, D. Bettex, C. Felix, T.F. Luscher, V. Falk, J. Grunenfelder, R. Corti. Heart. 2012;98: 126-32.

OR-143 Expression of the aging gene p66Shc is increased in peripheral blood monocytes of patients with acute coronary syndrome but not with stable coronary artery disease. F.C. Franzeck, D. Hof, R.D. Spescha, M. Hasun, A. Akhmedov, J. Steffel, Y. Shi, F. Cosentino, F.C. Tanner, A. von Eckardstein, W. Maier, T.F. Lüscher, C.A. Wyss, G.G. Camici. Atherosclerosis. 2012; 220:282-6.

OR-144 Takotsubo cardiomyopathy has a unique cardiac biomarker profile: NT proBNP/myoglobin and NT-proBNP/troponin T ratios for the differential diagnosis of acute coronary syndromes and stress induced cardiomyopathy. G.M. Fröhlich, B. Schoch, F. Schmid, P. Keller, I. Sudano, T.F. Lüscher, G. Noll, F. Ruschitzka, F. Enseleit. Int J Cardiol. 2012;154:328-32.

OR-145 Cardiovascular effects of flavanol-rich chocolate in patients with heart failure. A.J. Flammer, I. Sudano, M. Wolfrum, R. Thomas, F. Enseleit, D. Périat, P. Kaiser, A. Hirt, M. Hermann, M. Serafini, A. Lévêques, T.F. Lüscher, F. Ruschitzka, G. Noll, R. Corti. Eur Heart J. 2012;33: 2172-80.

OR-146 Reconstituted HDL in acute coronary syndromes. R. Chenevard, D. Hürlimann, L. Spieker, M. Béchir, F. Enseleit, M. Hermann, A.J. Flammer, I. Sudano, R. Corti, T.F. Lüscher, G. Noll, F. Ruschitzka. Cardiovasc Ther. 2012;30:51-7.

OR-147 Effects of Pycnogenol on endothelial function in patients with stable coronary artery disease: a double-blind, randomized, placebo-controlled, cross-over study. F. Enseleit, I. Sudano, D. Périat, S. Winnik, M. Wolfrum, A.J. Flammer, G.M. Fröhlich, P. Kaiser, A. Hirt, S.R. Haile, N. Krasniqi, C.M. Matter, K. Uhlenhut, P. Högger, M. Neidhart, T.F. Lüscher, F. Ruschitzka, G. Noll. Eur Heart J. 2012;33:1589-97.

OR-148 NT-proBNP provides incremental prognostic information in cardiac outpatients with and with-out echocardiographic findings. S. Toggweiler, O. Borst, F. Enseleit, M. Hermann, F. Ruschi-tzka, T.F. Lüscher, G. Noll.Clin Cardiol. 2011;34:183-8.

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OR-149 Long-term follow-up of patients with isolated left ventricular noncompaction: Role of electro-cardiography in predicting poor outcome. J. Steffel, D. Hürlimann, M. Namdar, D. Despotovic, R. Kobza, T. Wolber, J. Holzmeister, L. Haegeli, C. Brunckhorst, T.F. Lüscher, R. Jenni, F. Duru. Circ J. 2011;75;1728-34.

OR-150 Characteristics and long-term outcome of echocardiographic super-responders to cardiac resynchronisation therapy: 'real world' experience from a single tertiary care centre. J. Steffel, G. Milosevic, A. Hürlimann, N. Krasniqi, M. Namdar, F. Ruschitzka, T.F. Lüscher, F. Duru, J. Holzmeister, D. Hürlimann. Heart. 2011;97:1668-74.

OR-151 Transcatheter aortic valve implantation (TAVI) outcome according to standardized endpoint definitions by the Valve Academic Research Consortium (VARC). B.E. Stähli, R. Bünzli, J. Grünenfelder, I. Bühler, C. Felix, D. Bettex, P. Biaggi, F.C. Tanner, D.L. Nguyen-Kim, A. Plass, H. Ge, V. Falk, T.F. Lüscher, R. Corti, W. Maier, L.A. Altwegg. J Invasive Cardiol. 2011;23:307-312.

OR-152 Nebivolol exerts beneficial effects on endothelial function, early endothelial progenitor cells, myocardial neovascularization, and left ventricular dysfunction early after myocardial infarc-tion beyond conventional β1-blockade. S.A. Sorrentino, C. Doerries, C. Manes, T. Speer, C. Dessy, I. Lobysheva, W. Mohmand, R. Akbar, F. Bahlmann, C. Besler, A. Schaefer, D. Hilfi-ker-Kleiner, T.F. Lüscher, J.L. Balligand, H. Drexler, U. Landmesser. J Am Coll Cardiol. 2011; 57:601-11.

OR-153 Myeloid related proteins activate Toll-like receptor 4 in human acute coronary syndromes. K. Yonekawa, M. Neidhart, L.A. Altwegg, C.A. Wyss, R. Corti, T. Vogl, M. Grigorian, S. Gay, T.F. Lüscher, W. Maier. Atherosclerosis. 2011;218:486-92.

OR-154 Deletion of L-selectin increases atherosclerosis development in ApoE-/- mice. I. Rozenberg, S.H. Sluka, P. Mocharla, A. Hallenberg, P. Rotzius, J. Borén, N. Kränkel, U. Landmesser, L. Borsig, T.F. Lüscher, E.E. Eriksson, F.C. Tanner. PLoS One. 2011;6:e21675.

OR-155 Impact of cardiac hybrid single-photon emission computed tomography/computed tomogra-phy imaging on choice of treatment strategy in coronary artery disease. A.P. Pazhenkottil, R. NkoulouN, J.R. Ghadri, B.A. Herzog, S.M. Küest, L. Husmann, M. Wolfrum, R. Goetti, R.R. Buechel, O. Gaemperli, T.F. Lüscher, P.A. Kaufmann. Eur Heart J. 2011;32:2824-9.

OR-156 Arrhythmic manifestations in patients with congenital left ventricular aneurysms and diverti-cula. L.M. Haegeli, E. Ercin, T. Wolber, C. Brunckhorst, F.C. Tanner, R. Jenni, T.F. Lüscher, F. Duru. Am J Cardiol. 2011;108:1826-30.

OR-157 Long-term follow-up of patients with isolated left ventricular noncompaction: Role of electro-cardiography in predicting poor outcome. J. Steffel, D. Hürlimann, M. Namdar, D. Despotovic, R. Kobza, T. Wolber, J. Holzmeister, L. Haegeli, T.F. Lüscher, R. Jenni, F. Duru. Circ J. 2011;75:1728-34.

OR-158 Oxidized low density lipoprotein (oxLDL) mediated p66shc activation and reactive oxygen species (ROS) production goes through lectin-like oxidized LDL receptor-1 (LOX-1) and mediated by protein kinase C beta and c-Jun N-terminal kinase in human aortic endothelial cells. Y. Shi, F. Cosentino, G.G. Camici, A. Akhmedov, P.M. Vanhoutte, F.C. Tanner, T.F. Lüscher. Arterioscler Thromb Vasc Biol. 2011;31:2090-7.

OR-159 Dietary α-linolenic acid diminishes experimental atherogenesis and restricts T cell-driven inflammation. S. Winnik, C. Lohmann, E.K. Richter, N. Schäfer, W.L. Song, F. Leiber, P. Mocharla, J. Hofmann, R. Klingenberg, J. Borén, B. Becher, G.A. Fitzgerald, T.F. Lüscher, C.M. Matter, J.H. Beer. Eur Heart J. 2011;32:2573-84.

OR-160 Acute, subacute, and chronic myocardial infarction: Quantitative comparison of 2D and 3D Late gadolinium enhancement MR Imaging. R. Goetti, S. Kozerke, O.F. Donati, D. Sürder, P. Stolzmann, P.A. Kaufmann, T.F. Lüscher, R. Corti, R. Manka. Radiology. 2011;259:704-11.

OR-161 Sirt1 inhibition promotes in vivo arterial thrombosis and tissue factor expression in stimulated cells. A. Breitenstein, S. Stein, E.W. Holy, G.G. Camici, C. Lohmann, A. Akhmedov, R. Spe-scha, P.J. Elliott, C.H. Westphal, C.M. Matter, T.F. Lüscher, F.C. Tanner. Cardiovasc Res. 2011;89:464-72.

OR-162 Electrocardiographic changes in early recognition of Fabry disease. M. Namdar, J. Steffel, M. Vidovic, C.B. Brunckhorst, J. Holzmeiste, T.F. Lüscher, R. Jenni, F. Duru. Heart. 2011;97: 485-90.

OR-163 Mechanisms underlying adverse effects of highdensity lipoprotein on endothelial NO syntha- seactivating pathways in coronary artery disease. C. Besler, K. Heinrich, L. Rohrer, C. Doer-ries, M. Riwanto, D.M. Shih, A. Chroni, K. Yonekawa, S. Stein, N. Schaefer, M. Mueller, A. Akhmedov, C. Manes, C. Wyss, W. Maier, F.C. Tanner, C.M. Matter, R. Corti, C.Furlong, A.J. Lusis, A. von Eckardstein, A.M. Fogelman, T.F. Lüscher, U. Landmesser. J Clin Invest. 2011;121:2693-708.

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OR-164 Fibroblast activation protein is induced by inflammation and degrades type I collagen in thin-cap fibroatheromata. C.E. Brokopp, R. Schoenauer, P. Richards, S. Bauer, C. Lohmann, M.Y. Emmert, B. Weber, S. Winnik, E. Aikawa, K. Graves, M. Genoni, P. Vogt, T.F. Lüscher, C. Renner, S.P. Hoerstrup, C.M. Matter. Eur Heart J. 2011;32:2713-22.

OR-165 Complex cardiac anatomy and catheter access: the role of imaging in patients referred for catheter ablation. L.M. Haegeli, M. Greutmann, T. Wolber, P. Appenzeller, O. Gaemperli, C. Brunckhorst, T.F. Lüscher, F. Duru. Europace. 2011;13:1203-5.

OR-166 The prognostic value of N-terminal proBNP in patients undergoing acute left main revascu-larization. L. Jaberg, S. Toggweiler, M. Puck, T.F. Lüscher, R. Corti. Circ J. 2011;75:2648-53.

OR-167 Histamine receptor promotes atherosclerotic lesion formation by increasing vascular permea-bility for low-density lipoproteins. I. Rozenberg, S.H. Sluka, L. Rohrer, J. Hofmann, B. Becher, A. Akhmedov, J. Soliz, P. Mocharla, J. Borén, P. Johansen, J. Steffel, T. Watanabe, T.F. Lüscher, F.C. Tanner. Arterioscler Thromb Vasc Biol. 2010;30: 923-30.

OR-168 Coronary optical frequency domain imaging (OFDI) for in vivo evaluation of stent healing: comparison with light and electron microscopy. C. Templin, M. Meyer, M.F. Müller, V. Djonov, R. Hlushchuk, I. Dimova, S. Flueckiger, P. Kronen, M. Sidler, K. Klein, F. Nicholls, J.R. Ghadri, K. Weber, D. Paunovic, R. Corti, S.P. Hoerstrup, T.F. Lüscher, U. Landmesser. Eur Heart J. 2010;31:1792-801.

OR-169 Implantable cardioverter-defibrillator and cardiac resynchronization therapy in patients with left ventricular noncompaction. R. Kobza R, J. Steffel, P. Erne, A.W. Schoenenberger, D. Hürlimann, T.F. Lüscher, R. Jenni, F. Duru. Heart Rhythm. 2010;7:1545-9.

OR-170 Usefulness of additional coronary calcium scoring in low-dose CT coronary angiography with prospective ECG-triggering impact on total effective radiation dose and diagnostic accuracy. L. Husmann, B.A. Herzog, I.A. Burger, R.R. Buechel, A.P. Pazhenkottil, P. von Schulthess, C.A. Wyss, O. Gaemperli, U. Landmesser, P.A. Kaufmann. Acad Radiol. 2010;17:201-6.

OR-171 Impaired endothelial repair capacity of early endothelial progenitor cells in prehypertension: relation to endothelial dysfunction. G. Giannotti, C. Doerries, P.S. Mocharla, M.F. Mueller, F.H. Bahlmann, T. Horvàth, H. Jiang, S.A. Sorrentino, N. Steenken, C. Manes, M. Marzilli, K.L. Rudolph, T.F. Lüscher, H. Drexler, U. Landmesser. Hypertension. 2010;55:1389-97.

OR-172 Nuclear myocardial perfusion imaging with a cadmium-zinc-telluride detector technique: opti-mized protocol for scan time reduction. B.A. Herzog, R.R. Buechel, R. Katz, M. Brueckner, L. Husmann, I.A. Burger, A.P. Pazhenkottil, I. Valenta, O. Gaemperli, V. Treyer, P.A. Kaufmann. J Nucl Med. 2010;51:46-51.

OR-173 Ultrafast nuclear myocardial perfusion imaging on a new gamma camera with semiconductor detector technique: first clinical validation. R.R. Buechel, B.A. Herzog, L. Husmann, I.A. Burger, A.P. Pazhenkottil, V. Treyer, I. Valenta, P. von Schulthess, R. Nkoulou, C.A. Wyss, P.A. Kaufmann. Eur J Nucl Med Mol Imag. 2010;37:773-8.

OR-174 Myocardial perfusion imaging with real-time respiratory triggering: impact of inspiration breath-hold on left ventricular functional parameters. R.R. Buechel, L. Husmann, A.P. Pa-zhenkottil, R. Nkoulou, B.A. Herzog, I.A. Burger, J.R. Ghadri, M. Wolfrum, P.A. Kaufmann. J Nucl Cardiol. 2010;17:848-52.

OR-175 Cellular actors, Toll-like receptors, and local cytokine profile in acute coronary syndromes. C.A. Wyss, M. Neidhart, L. Altwegg, K.S. Spanaus, K. Yonekawa, M.B. Wischnewsky, R. Corti, N. Kucher, M. Roffi, F.R. Eberli, B. Amann-Vesti, S. Gay, A. von Eckardstein, T.F. Lüscher, W. Maier. Eur Heart J. 2010;31:1457-69.

OR-176 Real-time breath-hold triggering of myocardial perfusion imaging with a novel cadmium-zinc-telluride detector gamma camera. R.R. Buechel, A.P. Pazhenkottil, B.A. Herzog, L. Hus-mann, R.N. Nkoulou, I.A. Burger, I. Valenta, C.A. Wyss, J.R. Ghadri, P.A. Kaufmann. Eur J Nucl Med Mol Imag. 2010;37:1903-8.

OR-177 Performance of simultaneous cardiac-respiratory self-gated three-dimensional MR imaging of the heart, initial experience. R. Manka, M. Buehrer, P. Boesiger, E. Fleck, S. Kozerke. Radio-logy. 2010;255:909-16.

OR-178 Upgrading to resynchronization therapy after chronic right ventricular pacing improves left ventricular remodelling. G. Fröhlich, J. Steffel, D. Hürlimann, F. Enseleit, T.F. Lüscher, F. Ruschitzka, W.T. Abraham, J. Holzmeister. Eur Heart J. 2010;31:1477-85.

OR-179 ApoE-/- PGC-1α-/- mice display reduced IL-18 levels and do not develop enhanced athero-sclerosis. S. Stein, C. Lohmann, C. Handschin, E. Stenfeldt, J. Borén, T.F. Lüscher, C.M. Matter. PLoS One. 2010;5:e13539.

OR-180 Aging induces endothelial dysfunction while sparing arterial thrombosis. S.F. Stämpfli, A. Akhmedov, C. Gebhard, C. Lohmann, E.W. Holy, I. Rozenberg, R. Spescha, Y. Shi, T.F. Lüscher, F.C. Tanner, G.G. Camici.Arterioscler Thromb Vasc Biol. 2010;30:1960-7.

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OR-181 Acetaminophen increases blood pressure in patients with coronary artery disease. I. Sudano, A.A.J. Flammer, D. Périat, F. Enseleit, M. Hermann, M. Wolfrum, A. Hirt, P. Kaiser, D. Hurli-mann, M. Neidhart, S. Gay, J. Holzmeister, J. Nussberger, P. Mocharla, U. Landmesser, S.R. Haile, R. Corti, P.M. Vanhoutte, T.F. Lüscher, G. Noll, F. Ruschitzka. Circulation. 2010;122: 1789-96.

OR-182 SIRT1 decreases LOX-1-mediated foam cell formation in atherogenesis. S. Stein, C. Loh-mann, N. Schäfer, J. Hofmann, L. Rohrer, C. Besler, K.M. Rothgiesser, B. Becher, M.O. Hot-tiger, J. Borén, M.W. McBurney, C. Handschin, U. Landmesser, T.F. Lüscher, C.M. Matter. Eur Heart J. 2010;31:2301-9.

OR-183 Impact of stent overlap on angiographic and long-term clinical outcome in patients undergo-ing drug-eluting stent implantation. L. Räber, P. Jüni, L. Löffel, S. Wandel, S. Cook, P. Wena-weser, M. Togni, R. Vogel, C. Seiler, F. Eberli, T.F. Lüscher, B. Meier, S. Windecker. J Am Coll Cardiol. 2010;23:1178-88.

OR-184 Laminin receptor activation inhibits endothelial tissue factor expression.E.W. Holy, S.F. Stäm-pfli, A. Akhmedov, N. Holm, G.G. Camici, T.F. Lüscher, F.C. Tanner. J Mol Cell Cardiol. 2010;48:1138-45.

OR-185 Impaired endothelial repair capacity of early endothelial progenitor cells in prehypertension – relation to endothelial dysfunction. G. Giannotti, C. Doerries, P. Mocharla, M. Mueller, T. Hor-vàth, H. Jiang, S.A. Sorrentino, C. Manes, M. Marzilli, K.L. Rudolph, T.F. Lüscher, H. Drexler, U. Landmesser. Hypertension. 2010;55:1389-97.

OR-186 Amphetamines induce tissue factor and impair tissue factor pathway inhibitor: role of dopa-mine receptor type 4. C. Gebhard, A. Breitenstein, A. Akhmedov, C.E. Gebhard, G.G. Camici, T.F. Lüscher, F.C. Tanner. Eur Heart J. 2010;31:1780-91.

OR-187 PDGF-CC induces tissue factor expression: role of PDGF receptor alpha / beta. C. Gebhard, A. Akhmedov, P. Mocharla, J. Angstenberger, S. Sahbai, G.G. Camici, T.F. Lüscher, F.C. Tanner. Basic Res Cardiol. 2010;105:349-456.

OR-188 Rapamycin promotes arterial thrombosis in vivo: implications for everolimus and zotarolimus eluting stents. G.G. Camici, J. Steffel, I. Amanovic, A. Breitenstein, J. Baldinger, S. Keller, T.F. Lüscher, F.C. Tanner.Eur Heart J. 2010;31:236-42.

OR-189 Heart-infiltrating prominin-1+/CD133+ progenitor cells represent the cellular source of trans-forming growth factor beta-mediated cardiac fibrosis in experimental autoimmune myocar-ditis. G. Kania, P. Blyszczuk, S. Stein, A. Valaperti, D. Germano, S. Dirnhofer, L. Hunziker, C.M. Matter, U. Eriksson. Circ Res. 2009;105:462-70.

OR-190 Electrophysiological findings in patients with isolated left ventricular non-compaction. J. Stef-fel, R. Kobza, M. Namdar, T. Wolber, C. Brunckhorst, T.F. Lüscher, R. Jenni, F. Duru. Euro-pace. 2009;11:1193-200.

OR-191 Caffeine impairs myocardial blood flow response to physical exercise in patients with coro-nary artery disease as well as in age-matched controls. M. Namdar, T. Schepis, P. Köpfli, O. Gämperli, P.T. Siegrist, R. Grathwohl, I. Valenta,R. Delaloye, M. Klainguti,C. Wyss, T.F. Lüscher, P.A. Kaufmann. PloS One. 2009;4:e5665.

OR-192 A randomized placebo-controlled study on the effect of nifedipine on coronary endothelial function and plaque formation in patients with coronary artery disease: the ENCORE II study. T.F. Lüscher, M. Pieper, M. Tendera, M. Vrolix, W. Rutsch, F. van den Branden, R. Gil, K.O. Bischoff, M. Haude, D. Fischer, T. Meinertz, T. Münzel.Eur Heart J. 2009;30:1556-8.

OR-193 Atherosclerotic mice exhibit systemic inflammation in periadventitial and visceral adipose tissue, liver, and pancreatic islets. C. Lohmann, N. Schäfer, T. von Lukowicz, M.A. Sokrates Stein, J. Borén, S. Rütti, W. Wahli, M.Y. Donath, T.F. Lüscher, C.M. Matter. Atherosclerosis. 2009;207:360-7.

OR-194 Physician compliance with advanced electronic alerts for preventing venous thromboembo-lism among hospitalized medical patients. N. Kucher, M. Puck, J. Blaser, G. Bucklar, E. Esch-mann, T.F. Lüscher. J Thromb Haemost. 2009;7:1291-6.

OR-195 Cholesterylestertransfer protein inhibition and endothelial function in type II hyperlipidemia. F. Hermann, F. Enseleit, L.E. Spieker, D. Périat, I. Sudano, M. Hermann, R. Corti, G. Noll, F.T. Ruschitzka, T.F. Lüscher. Thromb Res. 2009;123:460-465.

OR-196 Heart transplantation in adolescent and adult patients with congenital heart disease: a case-control study. M. Greutmann, R. Prêtre, L. Furrer, U. Bauersfeld, M. Turina, G. Noll, T. F. Lüscher, P.T. Trindade. Transplant Proc. 2009;41:3821-6.

OR-197 Coronary CT angiography and myocardial perfusion imaging to detect flow-limiting stenoses: a potential gatekeeper for coronary revascularization? O. Gaemperli, L. Husmann, T. Sche-pis, P. Koepfli, I. Valenta, W. Jenni, H. Alkadhi, T.F. Lüscher, P.A. Kaufmann. Eur Heart J. 2009;30:2921-9.

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OR-198 Insufficient medication documentation at hospital admission of cardiac patients: a challenge for medication reconciliation. J P. Frei, L.C. Huber, R.W. Simon, M. Bonani, T.F. Lüscher. Cardiovasc Pharmacol. 2009;54:497-501.

OR-199 Effect of atazanavir versus other protease inhibitor-containing antiretroviral therapy on endo-thelial function in HIV-infected persons: randomised controlled trial. A.J. Flammer, N.T. Vo, B. Ledergerber, F. Hermann, A. Gämperli, A. Huttner, J. Evison, I. Baumgartner, M. Cavassini, D. Hayoz, K. Quitzau, M. Hersberger, I. Sudano, F. Ruschitzka, T.F. Lüscher, G. Noll, R. Weber. Heart. 2009;95:385-90.

OR-200 Vascular abnormalities, paraoxonase activity, and dysfunctional HDL in primary antiphospho-lipid syndrome. M. Charakida, C. Besler, JR Batuca, S. Sangle, S Marques, M. Sousa, G. Wang, D. Tousoulis, J. Delgado Alves, S.P. Loukogeorgakis, C. Mackworth-Young, D. D'Cruz, T.F. Luscher, U. Landmesser, J.E. Deanfield. JAMA. 2009;302:1210-17.

OR-201 Myeloid differentiation factor-88 / interleukin-1 signaling controls cardiac fibrosis and heart failure progression in inflammatory dilated cardiomyopathy.P. Blyszczuk, G. Kania, T. Die-terle, R.R. Marty, A. Valaperti, C. Berthonneche, T. Pedrazzini, C.T. Berger, S. Dirnhofer, C.M. Matter, J.M. Penninger, T.F. Lüscher, U. Eriksson. Circ Res. 2009;105:912-20.

OR-202 Ferric carboxymaltose in patients with heart failure and iron deficiency. S.D. Anker, J. Comin Colet, G. Filippatos, R. Willenheimer, K. Dickstein, H. Drexler, T.F. Lüscher, B. Bart, W. Banasiak, J. Niegowska, B.A. Kirwa, C. Mori, B. von Eisenhart Rothe, S.J. Pocock, P.A. Poole-Wilson, P. Ponikowski; FAIR-HF Trial Investigators. N Engl J Med. 2009;361:2436-48.

OR-203 PROGRESS-AMS (Clinical Performance Angiographic Results of Coronary Stenting with Absorbable Metal Stents) Investigators. Early- and long-term intravascular ultrasound and angiographic findings after bioabsorbable magnesium stent implantation in human coronary arteries. R. Waksman, R. Erbel, C. Di Mario, J. Bartunek, B. de Bruyne, F.R. Eberli, P. Erne, M. Haude, M. Horrigan, C. Ilsley, D. Böse, H. Bonnier, J. Koolen, T.F. Lüscher, N.J. Weissman. JACC Cardiovasc Interv. 2009;2:312-20.

OR-204 Combining dual-source computed tomography coronary angiography and calcium scoring: added value for the assessment of coronaryartery disease. Leschka, H. Scheffel, L. Des-biolles, A. Plass, O. Gaemperli, P. Stolzmann, M. Genoni, T.F. Lüscher, B. Marincek, P. Kaufmann, H. Alkadhi. Heart. 2008;94:1154-61.

OR-205 PARP1 is required for adhesion molecule expression in atherogenesis.T. von Lukowicz, P.O. Hassa, C. Lohmann, J. Borén, V. Braunersreuther, F. Mach, O. Odermatt, M. Gersbach, G.G. Camici, B.E. Stähli, F.C. Tanner, M.O. Hottiger, T.F. Lüscher, C.M. Matter. Cardiovasc Res. 2008;78:158-66.

OR-206 Prothrombotic gene expression profile in vascular smooth muscle cells of human saphenous vein, but not internal mammary artery. S.K. Payeli, R. Latini, C. Gebhard, A. Patrignani, U. Wagner, T.F. Lüscher, F.C. Tanner. Arterioscler Thromb Vasc Biol. 2008;28:705-10.

OR-207 Cardiac glycosides regulate endothelial tissue factor experession in culture.B.E. Stähli, A. Breitenstein, A. Akhmedov, G. G. Camici, K. Shojaati, N. Bogdanov, D. Ringli, T.F. Lüscher, F.C. Tanner. Arterioscl Thromb Vasc Biol. 2008;27:2769-76.

OR-208 Low-dose CT coronary angiography in the step-and-shoot mode: diagnostic performance H. Scheffel, H. Alkadhi, S. Leschka, A. Plass, L. Desbiolles, I. Guber, T. Krauss, J. Gruenen-felder, M. Genoni, T.F. Lüscher, B. Marincek, P. Stolzmann. Heart. 2008;94:1132-7.

OR-209 High spatial resolution myocardial perfusion cardiac magnetic resonance for the detection of coronary artery disease. S. Plein, S. Kozerke, D. Suerder, T.F. Lüscher, J.P. Greenwood, P. Boesiger, J. Schwitter. Eur Heart J. 2008;29:2148-55.

OR-210 Prothrombotic gene expression profile in vascular smooth muscle cells of human saphenous vein, but not internal mammary artery. S.K. Payeli, R. Latini, K. Gebhard, A. Patrignani, U. Wagner, T.F. Lüscher, F.C. Tanner. Arterioscler Thromb Vasc Biol. 2008;28:705-10.

OR-211 c-Jun N-terminal kinase 2 deficiency protects against hypercholesterolemia-induced endo-thelial dysfunction and oxidative stress.E. Osto, C.M. Matter, A. Kouroedov, T. Malinski T, M. Bachschmid, G.G. Camici, U. Kilic, T. Stallmach, J. Boren, S. Iliceto, T.F. Lüscher, F. Cosen-tino. Circulation. 2008;118:2073-80.

OR-212 Inhibition of protein kinase Cbeta prevents foam cell formation by reducing scavenger rece-ptor A expression in human macrophages. E. Osto, A. Kuroedov, P. Mocharla, A. Akhmedov, C. Besler, L. Rohrer, A. von Eckardstein, S. Iliceto, M. Volpe, T.F. Lüscher, F. Cosentino. Circulation. 2008;118:2174-82.

OR-213 Combining dual-source computed tomography coronary angiography and calcium scoring: added value for the assessment of coronary artery disease S. Leschka, H. Scheffel, L. Des-biolles, A. Plass, O. Gaemperli, P. Stolzman, M. Genoni, T.F. Lüscher, B. Marincek, P.A. Kaufman, H. Alkadhi. Heart. 2008;94:1154-61.

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OR-214 Endothelial nitric oxide synthase gene transfer inhibits human smooth muscle cell migration via inhibition of Rho A. T. Largiadèr, E. Masato, S.K. Payeli, H. Greutert, H. Viswambharan, M. Lachat, G. Zünd, Z. Yang, F.C. Tanner, T.F. Lüscher. J Cardiovasc Pharmacol. 2008;52: 369-74.

OR-215 Interaction of caffeine with regadenoson-induced hyperemic myocardial blood flow as mea-sured by positron emission tomography: a randomized, double-blind, placebo-controlled crossover trial. Gaemperli, T. Schepis, P. Koepfli, P. Siegrist, S. Fleischman, P. Nguyen, A. Olmsted, W. Wang, H. Lieu, P. Kaufmann. J Amer Coll Cardiol. 2008;51:328-9.

OR-216 Combining dual-source computed tomography coronary angiography and calcium scoring: added value for the assessment of coronary artery disease. S. Leschka, H. Scheffel, L. Des-biolles, A. Plass, O. Gaemperli, P. Stolzman, M. Genoni, T.F. Lüscher, B. Marincek, P.A. Kaufman, H. Alkhadi. Heart. 2008;94:1154-61.

OR-217 Angiotensin-converting enzyme inhibition improves vascular function in rheumatoid arthritis. A.J. Flammer, I. Sudano, F. Hermann, S. Gay, A. Forster, M. Neidhart, P. Künzler, F. Ense-leit, D. Périat, M. Hermann, J. Nussberger, T.F. Lüscher, R. Corti, G. Noll, F. Ruschitzka. Circulation. 2008;117:2262-9.

OR-218 Chronic Treatment with Tetrahydrobiopterin Reverses Endothelial Dysfunction and Oxidative Stress in Hypercholesterolemia. F. Cosentino, D. Hürlimann, C. Delli Gatti, R. Chenevard, N. Blau, N.J. Alp, K.M. Channon, M. Eto, P. Lerch, F. Enseleit, F. Ruschitzka, M. Volpe, T.F. Lüscher, G. Noll. Heart. 2008;94:487-92.

OR-219 Two-year clinical outcome after implantation of sirolimus-eluting and paclitaxel-eluting stents in diabetic patients. M. Billinger, J. Beutler, K.R. Taghetchian, A. Remondino, P. Wenaweser, S. Cook, M. Togni, C. Seiler, C. Stettler, F.R. Eberli, T.F. Lüscher, S.Wandel, P. Jüni, B. Meier, S. Windecker. Eur Heart J. 2008;29:718-25.

OR-220 Dual-source computed tomography coronary angiography: influence of obesity, calcium load, and heart rate on diagnostic accuracy.H. Alkadhi, H. Scheffel, L. Desbiolles, O. Gaemperli, P. Stolzmann, A. Plass, G.W. Goerres, T.F. Lüscher, M. Genoni, B. Marincek, P.A. Kaufmann, S. Leschka. Eur Heart J. 2008;29:766-76.

OR-221 Human antibody against the C domain of tenascin-C visualizes murine atherosclerotic pla-ques ex vivo. T. von Lukowicz, M. Silacci, M.T. Wyss, E. Trachsel, C. Lohmann, A. Buck, T.F. Lüscher, D. Neri, C.M. Matter. J Nucl Med. 2007;48:582-7.

OR-222 Impact of vessel size on outcome after implantation of sirolimus-eluting and paclitaxel-eluting stents: a subgroup analysis of the SIRTAX trial. M. Togni, S. Eber, J. Widmer, M. Billinger, P. Wenaweser, S. Cook, R. Vogel, C. Seiler, F.R. Eberli, W. Maier, R. Corti, M. Roffi, T.F. Lüscher, A. Garachemani, O.M. Hess, S. Wandel, B. Meier, P. Jüni, S. Windecker. J Am Coll Cardiol. 2007;50:1123-31.

OR-223 Inactivity of nitric oxide synthase gene in the atherosclerotic human carotid artery. F.C. Tanner, B. van der Loo, S. Shaw, H. Greutert, M.M. Bachschmid, M. Berrozpe, N. Blau, R. Siebenmann, J. Schmidli, P. Meyer, T.F. Lüscher. Basic Res Cardiol. 2007;102:308-17.

OR-224 Chronic treatment with long-acting nifedipine reduces vasoconstriction to endothelin-1 in essential hypertension.I. Sudano, A. Virdis, S. Taddei, L. Spieker, R. Corti, G. Noll, A. Salvetti, T.F. Lüscher. Hypertension. 2007;49:285-90.

OR-225 Cardiac glycosides regulate endothelial tissue factor expression in culture. B.E. Stähli, A. Breitenstein, A. Akhmedov, G.G. Camici, K. Shojaati, N. Bogdanov, J. Steffel, D. Ringli, T.F. Lüscher, F.C. Tanner. Arterioscler Thromb Vasc Biol. 2007;27:2769-76.

OR-226 Added value of coronary calcium score as an adjunct to gated SPECT for the evaluation of coronaryartery disease in an intermediate-risk population. T. Schepis, O. Gaemperli, P. Koe-pfli, M. Namdar, I. Valenta, H. Scheffel, S. Leschka, L. Husmann, F.R. Eberli, T.F. Luscher, H. Alkadhi, P.A. Kaufmann. J Nucl Med. 2007;48:1424-30.

OR-227 Cyclophyllin A differentially activates monocytes and endothelial cells: Role of purity, activity, and endotoxin contamination in commercial preparations. S.K. Payeli, C. Schiene-Fischer, J. Steffel, G.G. Camici, I. Rozenberg, T.F. Lüscher, F.C. Tanner. Atherosclerosis. 2007;197: 564-71.

OR-228 Asymmetrical dimethylarginine (ADMA) and coronary endothelial function in patients with coronary artery disease and mild hypercholesterolemia. R. Maas, K. Quitzau, E. Schwed-helm, L. Spieker, W. Rafflenbeul, A. Steenpass, T.F. Lüscher, R.H. Böger. Atherosclerosis. 2007;191:211-19.

OR-229 Systemic nitric oxide synthase inhibition improves coronary flow reserve to adenosine in patients with significant stenoses. P.A. Kaufmann, O.E. Rimoldi, T. Gnecchi-Ruscone, T.F. Lüscher, P.G. Camici. Am J Physiol Heart Circ Physiol. 2007;293:H2178-82.

Thomas F. Lüscher 23

OR-230 Cardiac image fusion from standalone SPECT and CT: Clinical experience. Gaemperli, T. Schepis, I. Valenta, L. Husmann, H. Scheffel, V. Duerst, F. Eberli, T.F. Lüscher, H. Alkadhi, P.A. Kaufmann. J Nucl Med. 2007;48:696-703.

OR-231 Dark chocolate improves coronary vasomotion and reduces platelet reactivity. A.J. Flammer, F. Hermann, I. Sudano, L. Spieker, M. Hermann, K.A. Cooper, M. Serafini, T.F. Lüscher, F. Ruschutzka, G. Noll, R. Corti. Circulation. 2007;116:2376-82.

OR-232 Effect of losartan, compared with atenolol, on endothelial function and oxidative stress in patients with type 2 diabetes and hypertension. A.J. Flammer, F. Hermann, P. Wiesli, B. Schwegler, R. Chenevard, D. Hürlimann, I. Sudano, S. Gay, M. Neidhart, W. Riesen, F. Ruschitzka, T.F. Lüscher, G. Noll, R. Lehmann. J Hypertension. 2007;25:785-91.

OR-233 Genetic deletion of p66Shc adaptor protein prevents hyperglycemia-induced endothelial dysfunction and oxidative stress. G.C. Camici, M. Schiavoni, P. Francia, M. Bachschmid, I. Martin-Padura, M. Hersberger, F.C. Tanner, P.G. Pelicci, M. Volpe, P. Anversa, T.F. Lüscher, F. Cosentino. Proc Natl Acad Sci. 2007;104:5217-22.

OR-234 Myeloid-related protein 8/14 complex is released by monocytes and granulocytes at the site of coronary occlusion: a novel, early, and sensitive marker of acute coronary syndromes. (fasttrack) L.A. Altwegg, M. Neidhart, M. Hersberger, S. Müller, F.R. Eberli, R. Corti, M. Roffi, G. Sütsch, S. Gay, A. von Eckardtstein, M.B. Wischnewsky, T.F. Lüscher, W. Maier. Eur Heart J. 2007;28:941-8.

OR-235 Paclitaxel enhances thrombin-induced endothelial tissue factor expression via c-jun terminal NH2 kinase activation. B.E. Stähli, G.C. Camici, J. Steffel, A. Akhmedov, K. Shoojati, M. Gra-ber, T.F. Lüscher, F.C. Tanner. Circ Res. 2006;99:149-55.

OR-236 C-reactive protein influences shear stress-dependent platelet adhesion in patients with fami-liar hypercholesterolemia and coronary artery disease undergoing LDL apherisis. L.E, Spie-ker, A.A.J. Flammer, N. Amacker, I. Sudano, J.J. Badimon, F. Ruschitzka, T.F. Lüscher, G. Noll, R. Corti. Thromb Haemost. 2006;96:540-2.

OR-237 Diabetes promotes cardiac stemm cell aging and heart failure, which are prevented by dele-tion of the p66shc gene. M. Rota, N. LeCapitaine, T. Hosoda, A. Boni, A. De Angelis, M. E. Padin-Iruegas, G. Esposito, S. Vitale, K. Urbanek, C. Casarsa, M. Giorgio, T.F. Lüscher, P.G. Pelicci, P. Anversa, A. Leri, J. Kajstura. Circulation. 2006;99;42-52.

OR-238 Dimethyl sulfoxide inhibits tissue factor expression, thrombus formation, and vascular smooth muscle cell activation. A potential treatment strategy for drug-eluting stents. G. Camici, J, Steffel, A. Akhmedov, N. Schafer, J. Baldinger, U. Schulz, K. Shojaati, C.M. Matter, Z. Yang, T.F. Lüscher, F.C. Tanner. Circulation. 2006;114:1512-21.

OR-239 Histamine differentially interacts with tumor necrosis factor-alpha and thrombin in endothelial tissue factor induction: Role of c-Jun terminal NH2 kinase. J. Steffel, C. Arnet, A. Akhmedov, S.M. Iseli, T.F. Lüscher, F.C. Tanner. J Thromb Haemost. 2006;11:2452-60.

OR-240 Increased ballon-induced inflammation, proliferation and neointima formation in apolipopro-tein E (ApoE) knockout mice. C.M. Matter, L. Ma, T. von Lukowicz, P. Meier, C. Lohmann, D. Zhang, U. Kilic, E. Hofmann, S. Woo Ha, M. Hersberger, D.M. Hermann, T.F. Lüscher. Stroke. 2006;36:2625-32.

OR-241 Differential effect of celecoxib on tissue factor expression in human endothelial and vascular smooth muscle cells. J. Steffel, A. Akhmendov, C. Fähndrich, F. Ruschitzka, T.F. Lüscher, F.C. Tanner. Biochem Biophys Res Comm. 2006;349:597-603.

OR-242 Dimethyl sulfoxide inhibits tissue factor expression, thrombus formation and vascular smooth muscle activation: A potential treatment strategy for drug-eluting stents. G.G. Camici, J. Stef-fel, A. Akhmedov, N. Schafer, J. Baldinger, U. Schulz, K. Shojaati, C.M. Matter, Z. Yang, T.F. Lüscher, F.C. Tanner. Circulation. 2006;114:1512-21.

OR-243 Reduced connexin43 expression limits neointima formation after balloon distension injury in hypercholesterolemic mice. C.E. Chadjichristos, C.M. Matter, I. Roth, E. Sutter, G. Pelli, T.F. Lüscher, M. Chanson, B.R. Kwak. Circulation. 2006;113:2835-43.

OR-244 Statins blunt thrombin-induced downregulation of endothelial nitric oxide synthase expression in human endothelial cells. M. Eto, L. Rathgeb, F. Cosentino, T. Kozai, T.F. Lüscher. J. Car-diovasc Pharmacol. 2006;47:663-7.

OR-245 18F-Choline images murine atherosclerotic plaques ex vivo. C.M. Matter, M.T. Wyss, P. Meier, N. Späth, T. von Lukowicz, C. Lohmann, B. Weber, A. Ramirez de Molina, J.C. Lacal, S.M. Ametamey, G.K. von Schulthess, T.F. Lüscher, P.A. Kaufmann, A. Buck. Arterioscler Thromb Vasc Biol. 2006;26:584-9.

OR-246 Role of endogenous Fas (CD95/Apo-1) ligand in balloon-induced apoptosis. Inflammation and neointima formation. C.M. Matter, C.E. Chadjichristos, P. Meier, T. von Lukowicz, C. Lohmann, T. Brunner, B.R. Kwak, T.F. Lüscher Circulation. 2006;113:1879-87.

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OR-247 Degenerative aortic valve stenosis, but not coronary disease, is associated with shorter tele-more length in the elderly. D.J. Kurz, B. Kloeckener-Gruissem, A. Akhemedov, F.R. Eberli, I. Bühler, W. Berger, O. Bertel, T.F. Lüscher. Arterioscler Thromb Vasc Biol. 2006;26:114-17.

OR-248 Expression and activity patterns of nitric oxide synthase and antioxidant enzymes reveal a substantial heterogeneity between cardiac and vascular aging in the rat. B. van der Loo, M. Bachschmid, R. Labugger, S. Schildknecht, J. Kilo, R. Hahn, M. Palacios-Callender, T.F. Lüscher. Biogerontology. 2006;6:325-34.

OR-249 Dark chocolate improves endothelial and platelet function. F. Hermann, L.E. Spieker, F. Ru-schitzka, I. Sudano, M. Hermann, C. Binggeli, T.F. Lüscher, W. Riesen, G. Noll, R. Corti. Heart. 2006;92:119-20.

OR-250 The Asp298 but not the C-786 genotype of the endothelial nitric oxide synthase is reduced with age in healthy Swiss men. Muntwyler, J. Marti-Jaun, T.F. Lüscher, E. Hänseler, M. Hers-berger. Clin Chem Lab Med. 2005;43:971-3.

OR-251 Rapamycin, but not FK-506, increases endothelial tissue factor expression: Implications for drug-eluting stent design. J. Steffel, R.A. Latini, A. Akhmedov, D. Zimmermann, P. Zimmer-ling, T.F. Lüscher, F.C. Tanner. Circulation. 2005;112:2002-11.

OR-252 Glycogen synthase kinase-3 mediates endothelial cell activation by tumor necrosis factor-alpha. M. Eto, A. Kouroedov, F. Cosentino, T.F. Lüscher. Circulation. 2005;112:1316-22.

OR-253 Sirolimus-eluting and paclitaxel-eluting stents for coronary revascularization. S. Windecker, A. Remondino, F.R. Eberli, P. Jüni, L. Räber, P. Wenaweser, M. Togni, M. Billinger, D. Tüller, C. Seiler, M. Roffi, R. Corti, G. Sütsch, W. Maier, T.F. Lüscher, O.M. Hess, M. Egger, B. Meier. New Engl J Med. 2005;353:653-62.

OR-254 Coffee blunts mental stress-induced blood pressure increase in habitual but not in nonhabi-tual coffee drinkers.I. Sudano, L. Spieker, C. Binggeli, F. Ruschitzka, T.F. Lüscher, G. Noll, R. Corti. Hypertension. 2005;46:521-6.

OR-255 The CAG repeat polymorphism of the androgen receptor gene is associated with HDL-cho-lesterol but not with coronary atherosclerosis or myocardial infarction. M. Hersberger, J. Muntwyler, H. Funke, J. Marti-Jaun, H. Schulte, G. Assmann, T.F. Lüscher, A. von Eckardt-stein. Clin Chemistry. 2005;51:1110-15.

OR-256 Simvastatin improves endothelial function in patients with rheumatoid arthritis. F. Hermann, A. Forster, R. Chenevard, F. Enseleit, D. Hürlimann, R. Corti, L.E. Spieker, D. Frey, M. Her-mann, W. Riesen, M. Neidhardt, B. Michel, J. Hellermann, R. Gay, T.F. Lüscher, S. Gay, G. Noll, F.T. Ruschitzka. J Amer Coll Cardiol. 2005;45:460-4.

OR-257 Integrated PET/CT for the assessement of coronary artery disease – a feasibility study. M. Namdar, T.F. Hany, P. Koepfli, P.T. Siegrist, C. Burger, C.A. Wyss, T.F. Lüscher, G.K. von Schulthess, P.A. Kaufmann. J Nucl Med. 2005;46:930-5.

OR-258 No evidence for involvement of the human inducible nitric oxide synthase gene in suscepti-bility to coronary artery disease (letter to the editor). J. Muntwyler, J. Marti-Jaun, T.F. Lü-scher, E. Hänseler, M. Hersberger. Clin Chem Lab Med. 2005;43:253-5.

OR-259 Histamine induces tissue factor: Implications for acute coronary syndromes. J. Steffel, A. Akhmedov, H. Greutert, T.F. Lüscher, F.C. Tanner. Circulation. 2005;112:341-9.

OR-260 Inflammatory markers at the site of ruptured plaque in acute myocardial infarction: Locally in-creased interleukin-6 and serum amyloid A but decreased C-reactive protein. W. Maier, L. Altwegg, R. Corti, S. Gay, M. Hersberger, F.E. Maly, G. Sütsch, M. Roffi, M. Neidhart, F.R. Eberli, F.C. Tanner, S. Gobbi, A. von Eckardtstein, T.F. Lüscher. Circulation. 2005;111:1355-61.

OR-261 Selective COX-2 inhibitors and renal injury in salt-sensitive hypertension. (with editorial) M. Hermann, S. Shaw, E. Kiss, G. Camici, N. Bühler, R. Chenevard, T.F. Lüscher, H.J. Gröne, F. Ruschitzka. Hypertension. 2005;45:1-5.

OR-262 Celecoxib decreases endothelial tissue factor expression through inhibition of JNK phosphor-rylation. J. Steffel, M. Hermann, H. Greutert, S. Gay, T.F. Lüscher, F. Ruschitzka, F.C. Tan-ner. Circulation. 2005;111:1685-9.

OR-263 Aggravation of focal cerebral ischemia by tissue plasminogen activator is reversed by 3-hy-droxy-3-methylglutaryl coenzyme A reductase inhibitor but does not depend on endothelial NO synthase. E. Kilic, U. Kilic, C.M. Matter, T.F. Lüschher, C.L. Bassetti, D.M. Hermann. Stroke. 2005;36:332-6.

OR-264 Systemic inhibition of nitric oxide synthase unmasks neural constraint of maximal myocardial blood flow in humans. P.A. Kaufmann, O. Rimoldi, T. Gnecchi-Rusconi, T.F. Lüscher, P.G. Camici. Circulation. 2004;110:1431-6.

Thomas F. Lüscher 25

OR-265 Molecular imaging of atherosclerotic plaques using a human antibody against the extra-do-main B of fibrinonectin. C.M. Matter, P.K. Schuler, P. Alessi, P. Meier, R. Ricci, D. Zhang, C. Halin, P. Castellani, L. Zardi, C.K. Hofer, M. Montani, D. Neri, T.F. Lüscher. Circ Res. 2004; 95:1225-33.

OR-266 JNK2 is required for scavenger receptor-A mediated foam cell formation and atherosgenesis. R. Ricci, G. Sumara, I.J. Sumara, I. Rosenberg, M. Kurrer, A. Akhmedov, M. Hersberger, F.R. Eberli, E.F. Wagner, C.M. Matter, T.F. Lüscher. Science. 2004;306:1558-61.

OR-267 Beta-Adrenergic blockade and myocardial perfusion in coronary artery disease: Differential effects in stenotic versus remote myocardial segments. P. Köpfli, C.A. Wyss, M. Nemdar, M. Klainguti, G. von Schulthess, T.F. Lüscher, P.A. Kaufmann. J Nucl Med. 2004;45:1626-31.

OR-268 Selective inhibition of PKC beta II as therapeutic approach to treatment of endothelial dys-function during acute hyperglycemia. (with editorial) Kouroedov, F. Cosentino, M. Eto, H. Joch, M. Vople, T.F. Lüscher. Circulation. 2004;110:91-6.

OR-269 Deletion of p66shc gene protects against age-related endothelial dysfunction. P. Francia, C. delli Gatti, M. Bachschmid, I. Martin-Padura, C. Savoia, E. Migliaccio, P.G. Pelicci, M. Schia-voni, T.F. Lüscher, M. Volpe, F. Cosentino. Circulation. 2004;110:2889-95.

OR-270 Long-term Effects of darusentan on LV remodeling and clinical outcomes – The Endothelin A Receptor Antagonist Trial in Heart Failure (EARTH). I.S. Anand, J. McMurray, J.N. Cohn, M.A. Konstam, T. Notter, K. Quitzau, F. Ruschitzka, T.F. Lüscher on behalf of the EARTH investigators. Lancet. 2004;364:347-54.

OR-271 Nitric oxide gene transfer inhibits biological features of bypass graft disease in the human saphenous vein. F. Tanner, T. Largiadèr, H. Greutert, Z. Yang, T.F. Lüscher. J Thorac Car-diovasc Surg. 2004;127:20-6.

OR-272 Oxidative stress-associated vascular aging is independent of the protein kinase C/NAD(P)H oxidase pathway. M. Bachschmid, B. van der Loo, K. Schüler, R. Labugger, S. Thurau, J. Kilo, R. Hölz, T.F. Lüscher, V. Ulrich. Arch Geront Geriatr. 2004;38:181-90.

OR-273 Age-related changes in vitamin A status. B. van der Loo, R. Labugger, C.P. Aebischer, M. Bachschmid, V. Spitzer, J. Kilo, L. Altwegg, V. Ulrich, T.F. Lüscher. J Cardiovasc Pharmacol. 2003;43:26-30.

OR-274 Different cell cycle regulation of vascular smooth muscle in genetic hypertension. F. Tanner, H. Greutert, C. Barandier, K. Frischknecht, T.F. Lüscher. Hypertension. 2003;42:184-8.

OR-275 Differential effects of selective cyclooxygenase-2 inhibition on endothelial function in salt-in-duced hypertension. M. Hermann, G. Camici, A. Fratton, D. Hürlimann, M. Fiedler, J. Thierry, M. Neidhart, R.E. Gay, S. Gay, T.F. Lüscher, F.T. Ruschitzka. Circulation. 2003;108:2308-11.

OR-276 Satins (HMG-CoA reductase inhibitors) reduce CD40 expression in human vascular cells. F. Mulhaupt, C.M. Matter, B.R. Kwak, G. Pelli, N.R. Veillard, F. Burger, P. Graber, T.F. Lüscher, F. Mach. Cardiovasc Res. 2003;59:755-66.

OR-277 ETA receptors mediate vasoconstriction of large conduit arteries during reduced flow in humans. L.E. Spieker, T.F. Lüscher, G. Noll.J Cardiovasc Pharmacol. 2003;42:315-18.

OR-278 Characterization of dysfunctional myocardium by positron emission tomography and magne-tic resonance: Relation to functional outcome after revascularization. P.R. Knuesel, D. Nanz, C. Wyss, M. Buechi, G.K. von Schulthess, T.F. Lüscher, J. Schwitter. Circulation. 2003;108: 1095-100.

OR-279 Decreased plasma and tissue levels of vitamin C in a rat model of aging: implications for oxi-dative defense. B. van der Loo, M. Bachschmid, V. Spitzer, L. Brey, V. Ullrich, T.F. Lüscher. Biochem Biophys Res Comm. 2003;303:483-7.

OR-280 Fibroblast growth factor-2, but not vascular endothelial growth factor, upregulates telomerase activity in human endothelial cells. D.J. Kurz, Y. Hong, E. Trivier, H.L. Huang, S. Decary, G.H. Zang, T.F. Lüscher, J.D. Erusalimsky. Arterioscler Thromb Vasc Biol. 2003;23:748-54.

OR-281 Detection of a novel exon 4 low-density lipoprotein receptor gene deletion in a Swissfamily with severe familial hypercholesterolemia. D. Neff, F. Ruschitzka, M. Hersberger, F. Enseleit, D. Hürlimann, G. Noll, T. F. Lüscher, E. Hänseler. Clin Chem Lab Med. 2003;41:266-71.

OR-282 Dysfunctional Baroreflex Regulation of Sympathetic Nerve Activity in Patients with Vasovagal Syncope. M. Béchir, C. Binggeli, R. Corti, R. Chenevard, F. Ruschitzka, T.F. Lüscher, G. Noll. Circulation. 2003;107:1620-5.

OR-283 Statins Enhance Post-Ischemic Hyperemia in the Skin Circulation of Hypercholesterol-emic Patients: A Monitoring Test of Endothelial Dysfunction for Clinical Practice? C. Binggeli, L.E. Spieker, R. Corti, I. Sudano, V. Stojanovic, D. Hayoz, T.F. Lüscher, G. Noll. J Amer Coll Cardiol. 2003;42:71-7.

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OR-284 Erythropoetin-induced excessive erythrocytosis activates the tissue endothelin system in mice. T. Quaschning, F. Ruschitzka, T. Stallmach, S. Shaw, H. Morawietz, W. Goettsch, M. Hermann, T. Slowinski, F. Theuring, B. Hocher, T.F. Lüscher, M. Gassmann. FASEB J. 2003;17:259-61.

OR-285 Selective COX-2 inhibition improves endothelial function in coronary artery disease. R. Che-nevard, D. Hürlimann, M. Béchir, F. Enseleit, L. Spieker, M. Hermann, W. Riesen, S. Gay, R. Gay, M. Neidhart, T.F. Lüscher, G. Noll, F. Ruschitzka. Circulation. 2003;107:405-9.

OR-286 High glucose causes upregulation of cyclooxygenase-2 and alters prostanoid profile in hu-man endothelial cells: Role of protein kinase C and reactive oxygen species.F. Cosentino, M. Eto, P. de Paolis, B. van der Loo, M. Bachschmid, V. Ulrich, A. Kouroedov, C. delle Gatti, M. Volpe, T.F. Lüscher. Circulation. 2003;107:1017-1023.

OR-287 Effects of nifedipine and cerivastatin on coronary endothelial function. The ENCORE-1 trial. T.F. Lüscher on behalf of the ENCORE investigators. Circulation. 2003;107:422-8.

OR-288 Hemodynamic and neurohumoral effects of selective endothelin A (ETA) receptor blockade in chronic heart failure: The heart failure ETA receptor blockade trial (HEAT). T.F. Lüscher, F. Enseleit, R. Pacher, V. Mitrovic, M.R. Schulze, R. Willenbrock, R. Dietz, V. Rousson, D. Hürli-mann, S. Philipp, T. Notter, G. Noll, F. Ruschitzka. Circulation. 2002;106:2666-72.

OR-289 Coffee acutely increases sympathetic nerve activity and blood pressure independently of caf-feine content: Role of habitual vs. non-habitual drinking. R. Corti, C. Binggeli, I. Sudano, L. Spieker, E. Hänseler, F. Ruschitzka, W.F. Chaplin, T.F. Lüscher, Georg Noll. Circulation. 2002;106:2935-40.

OR-290 Anti-tumor necrosis factor-alpha treatment improves endothelial function in patients with rheumatoid arthritis. D. Hürlimann, A. Forster, G. Noll, F. Enseleit, R. Chenevard, O. Distler, M. Béchir, L.E. Spieker, M. Neidhart, B.A. Michel, R.E. Gay, T.F. Lüscher, S. Gay, F. Ruschitzka. Circulation. 2002;106:2184-7.

OR-291 Mental stress induces prolonged endothelial dysfunction via endothelin A receptors. L. Spie-ker, D. Hürlimann, F. Ruschitzka, R. Corti, F. Enseleit, S. Shaw, D. Hayoz, J.E. Deanfield, T.F. Lüscher, G. Noll. Circulation. 2002; 105:2817-20.

OR-292 ECG-gated multi-detector row CT for assessement of mitral valve disease: Initial experience. J.K. Willmann, R. Kobza, J.E. Roos, M. Lachat, R. Jenni, P.R. Hilfiker,T.F. Lüscher, B. Marin-cek, D. Weishaupt. Eur Radiology. 2002;12:2662-9.

OR-293 Electrocardiographically gated multi-detector row CT for assessement of valvular morphology and calcification in aortic stenosis. J.K. Willmann, D. Weishaupt, M. Lachat, R. Kobza, J.E. Roos, B. Seifert, T.F. Lüscher, B. Marincek, P.R. Hilfiker. Radiology. 2002;225:120-8.

OR-294 Statin Prevents Tissue Factor Expression in Human Endothelial Cells: Role of Rho/Rho-Ki-nase and Akt Pathways. M. Eto, T. Kozai, F. Cosentino, H. Joch, T.F Lüscher. Circulation. 2002;15:1765-59.

OR-295 Cardiovascular aging is associated with Vitamin E increase. B. van der Loo, R. Labugger, C.P. Aebischer, J.N. Skepper, M. Bachschmid, V. Spitzer, J. Kilo, L. Altwegg, V. Ullrich, T.F. Lüscher. Circulation. 2002;105:1635-8.

OR-296 Reconstituted high density lipoproteins normalize endothelial function in hypercholesterin-emia. L. Spieker, D. Hürlimann, F. Enseleit, T.F. Lüscher, G. Noll. Circulation. 2002;105:1399 -402.

OR-297 Effects of chronic calcium channel blockade on muscle sympathetic nerve activity in hypert-ension: The Vera Trial comparing nifedipine, amlodipine and verapamil. C. Binggeli, R. Corti, I. Sudano, T.F. Lüscher, G. Noll. Hypertension. 2002;39:892-6.

OR-298 Nitric-oxide-mediated relaxations in salt-induced hypertension: effect of chronic ß1 selective receptor blockade. F. Cosentino, S. Bonetti, R. Rehorik, M. Eto, G. Werner-Felmayer, M. Volpe, T.F. Lüscher. J Hypertension. 2002;20:421-8.

OR-299 Chronic ETA receptor blockade prevents endothelial dysfunction of the microcirculation in apolipoprotein E-deficient mice. L. D’Uscio, M. Barton, S. Shaw, C.C. Haudenschild, T.F. Lüscher. Cardiovasc Res. 2002;53:487-95.

OR-300 Felodipine inhibits human smooth muscle cell growth by blockade of nuclear translocation of p42/44 mitogen-activated protein kinase. Z. Yang, A. Madinova, T. Kozai, H. Joch, U. Aebi, T.F. Lüscher Cardiovasc Res. 2002;53:227-31.

OR-301 Thrombin suppresses endothelial nitric oxide synthase and upregulates endothelin-converting enzyme-1 expression by distinct pathways: Role of Rho/ROCK and mitogen-activated protein kinase. M. Eto, C. Barandier, L. Rathgeb, T. Kozai, H. Joch, Z. Yang, T.F. Lüscher. Circ. Res. 2001;89:583-90.

OR-302 Influence of aldosterone vs endothelin receptor antagonism on renovascular function in li-quorrice-induced hypertension. T. Quaschning, F. Ruschitzka, B. Niggli, C.M.B. Lunt, S. Shaw, M. Christ, M. Wehling, T.F. Lüscher. Nephrol Dial Transplant. 2001;162146-51.

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OR-303 Predictors of long-term survival after valve replacement for chronic aortic regurgitation: Is M-mode echocardiography sufficient? R. Corti, C. Binggeli, M. Turina, R. Jenni, T.F. Lüscher, J. Turina. Eur Heart J. 2001;22:866-73.

OR-304 Chronic vasopeptidase inhibition restores endothelin-converting enzyme activity and norma-lizes endothelin levels in salt-induced hypertension. T. Quaschning, L.V. d'Uscio, S. Shaw, H. Viswambharan, F.T. Ruschitzka, T.F. Lüscher. Nephrol Dial Transplant. 2001;16:1176-82.

OR-305 ETA receptor antagonism prevents vascular dysfunction in 11ß-hydroxysteroid dehydrogena-se deficient hypertension. Role of Nitric Oxide. F. Ruschitzka, T. Quaschning, G. Noll , A. de Gottardi, M. Rossier, F. Enseleit, T.F. Lüscher, S. Shaw. Circulation. 2001;103:3129-35.

OR-306 Vasopeptidase inhibition restores renovascular endothelial dysfunction in salt-induced hype-rtension. T. Quaschning, L.V. d'Uscio, S. Shaw, H.J. Gröne, F. T. Ruschitzka, T.F. Lüscher. J Amer Soc Nephrol. 2001;12:2280-7.

OR-307 Vasopeptidase inhibition exhibits endothelial protection in salt-induced hypertension. T. Qua-schning, L.V. d'Uscio, S. Shaw, H.J. Gröne, F.T. Ruschitzka, T.F. Lüscher. Nephrol Dial Transplant. 2001;16:1176-82.

OR-308 Vasopeptidase inhibition exhibits endothelial protection in salt-induced hypertension. T. Quaschning, L.V. d'Uscio, S. Shaw, T.F. Lüscher. Hypertension. 2001;37:1108-13.

OR-309 Assessement of myocardial perfusion in coronary artery disease by magnetic resonance: A comparison with positron emission tomography and coronary angiography. J. Schwitter, D. Nanz, S. Kneifel, K. Bertschinger, M. Büchi, P.R. Knüsel, B. Marincek, T.F. Lüscher, G.K. von Schulthess. Circulation. 2001;103:2230-5.

OR-310 Aldosterone receptor antagonism normalizes vascular function in liquorice-induced hyperten-sion. T. Quaschning, F.T. Ruschitzka, S. Shaw, T.F. Lüscher Hypertension. 2001;37:801-5.

OR-311 Reactive oxygen species mediate endothelium-dependent relaxations in tetrahydrobiopterin deficient mice. F. Cosentino, J.E. Barker, M.P. Brand, S.J. Heales, E.R. Werner, J.R. Tippins, N. West, K.M. Channon, M. Volpe, T.F. Lüscher. Arterioscl Thromb Vasc Biol. 2001;21:496-502.

OR-312 Vasopeptidase inhibition prevents endothelial dysfunction of resistance arteries in salt-sen-sitive hypertension in comparison with single ACE-inhibition. L. d’Uscio, T. Quaschning, M. Barton, D. Heublein, J.C. Burnett Jr., T.F. Lüscher. Hypertension. 2001;37:28-33.

OR-313 Nitric oxide production by isolated human and porcine ciliary processes. T. Haufschild, M.R. Tschudi, A.J. Flammer, T.F. Lüscher, I.O. Haefliger. Graefes Arch Clin Exp Ophthalmol. 2000;238:248-53.

OR-314 HMG-CoA reductase inhibition improves endothelial cell function and inhibits smooth muscle cell proliferation in human saphenous veins. Z. Yang, T. Kozai, B. van der Loo, H. Veswam-bharan, M. Lachat, M.I. Turina, T. Malinski, T.F. Lüscher. J Amer Coll Cardiol. 2000;36:1691-7.

OR-315 Enhanced peroxynitrite formation is associated with vascular aging. B. van der Loo, R. Labugger, J.N. Skepper, M. Bachschmid, J. Kilo, J.M. Powell, M. Palacios-Callender, J. D. Erusalimsky, T. Quaschning, T. Malinski, D. Gygi, V. Ullrich, T.F. Lüscher. J Exp Med. 2000;192:1731-43.

OR-316 Endothelin regulates angiotensin-converting enzyme in the mouse kidney. M. Barton, R. Carmona, J.E. Krieger, W. Göettsch, H. Morawietz, L. d’Uscio, T. Lattmann, T.F. Lüscher, S. Shaw. J Cardiovasc Pharmacol. 2000;36 (5Suppl. 1):S244-7.

OR-317 Dysfunctional renal nitric oxide synthase as a determinant of salt- sensitive hypertension: mechanisms of renal artery endothelial dysfunction and role of endothelin for vascular hyper-trophy and Glomerulosclerosis. M. Barton, I. Vos , S. Shaw, P. Boer, L.V. d'Uscio, H.J. Gro-ne, T.J. Rabelink, T. Lattmann, P. Moreau, T.F. Lüscher. J Am Soc Nephrol. 2000;11:835-45.

OR-318 Inverse regulation of endothelin-1 and nitric oxide metabolites in tissue with aging: Implica-tions for the age-dependent increase of cardiorenal disease. M. Barton, T. Lattmann, L. d’Uscio, T.F. Lüscher, S. Shaw. J Cardiovasc Pharmacol. 2000;36(5Suppl. 1):153-6.

OR-319 Nitric oxide prevents cardiovascular disease and determines survival in polyglobulic mice overexpressing erythropoietin F. Ruschitzka, R. Wenger, T. Stallmach, T. Quaschning, C. de Vit, R. Labugger, M. Kelm, G. Noll, T. Rühlicke, S. Shaw, R. Lindberg, B. Rodenwald, H. Lutz, C. Bauer, T.F. Lüscher, M. Gassmann. Proc Natl Acad Sci USA. 2000;97:11609-13.

OR-320 Tissue endothelin-converting enzyme activity correlates with cardiovascular risk factors in coronary artery disease. F. Ruschitzka, U. Moehrlein, T. Quaschning, M. Lachat, G. Noll, S. Shaw, Z. Yang, D. Teubser, T. Subkowski, M.I. Turina, T.F. Lüscher. Circulation. 2000;102: 1086-92.

OR-321 Coronary heart disease in smokers: Vitamin C restores microcirculatory function. P.A. Kaufmann, T. Gnecchi-Ruscone, M. di Terlizzi, K.P. Schäfers, T.F. Lüscher, P.G. Camici. Circulation. 2000;102:1233-8.

Thomas F. Lüscher 28

OR-322 Aging, serum estradiol levels, and pregnancy differentially affect vascular reactivity of the rat uterine artery. E. Wight, C.F. Küng, P. Moreau, H. Takase, N.A. Bersinger, T.F. Lüscher. J Soc Gynecol Investig. 2000;7:106-13.

OR-323 Nebivolol induces NO-mediated relaxations in small mesenteric but not large elastic arteries. L. Altwegg, L. d’Uscio, C. Baradier, F. Cosentino, Z. Yang, T.F. Lüscher. J Cardiovasc Pharmacol. 2000;36:316-20.

OR-324 Systemic, pulmonary and renal hemodynamic effects of Endothelin ETA/B Receptor blockade

in patients with maintained left ventricular function M. Fleisch, G. Sütsch, Xiao Wei Yan, R.R. Wenzel, C. Binggeli, M.G. Bianchetti, B. Meier, W. Kiowski, T.F. Lüscher. J Cardiovasc Pharmacol. 2000;36:302-9.

OR-325 Low density lipoprotein cholesterol and coronary microvascular dysfunction in hypercholes-terolemia. P.A. Kaufmann, T. Gnecchi-Ruscone, K.P. Schäfers, T.F. Lüscher, P.G. Camici. J Amer Coll Cardiol. 2000;36:103-9..

OR-326 Nitric oxide modulates expression of cell cycle regulatory prteins: A cytostatic strategy for inhibition of human vascular smooth muscle cell proliferation. F.C. Tanner, P. Meier, H. Greutert, C. Champion, E.G. Nabel, T.F. Lüscher. Circulation. 2000;101:1982-9.

OR-327 Baroreceptor dysfunction induced by nitric oxide synthase inhibition. L.E. Spieker, R. Corti, C. Binggeli, T.F. Lüscher, G. Noll. J Amer Coll Cardiol. 2000;36:213-18.

OR-328 Acute hemodynamic and neurohumoral effects of selective ETA receptor blockade in patients with congestive heart failure. L.E. Spieker, V. Mitrovic, G. Noll, R. Pacher, M.R. Schulze, J. Muntwyler, C. Schalcher, W. Kiowski, T.F. Lüscher on behalf of the ET 003 investigators. J Amer Coll Cardiol. 2000;35:1745-52.

OR-329 Nebivolol inhibits human aortic smooth muscle cell growth: Effect on cell cycle regulatory machanisms. D.E. André, U. Arnet, Z. Yang, T.F. Lüscher. J Cardiovasc Pharmacol. 2000;35:845-8.

OR-330 Efficacy and tolerability of fluvastatin and bezafibrate in patients with hyperlipidemia and persistantly high triglceride levels. L.E. Spieker, G. Noll, M. Hannak, T.F. Lüscher. J Cardiovasc Pharmacol. 2000;35:361-5.

OR-331 Tetrahydrobiopterin imporves endothelial function in patients with coronary artery disease. W. Maier, F. Cosentino, R.B. Lütolf, M. Fleisch, C. Seiler, O.M. Hess, B. Meier, T.F. Lüscher. J Cardiovasc Pharmacol. 2000;35:173-8.

OR-332 Acute heart transplant rejection due to St. John’s wort. F. Ruschitzka, P.J. Meier, M. Turina, T.F. Lüscher, G. Noll. Lancet. 2000;355:548-9.

OR-333 Magnetic resonance-based assessement of global flow and flow reserve and ist relation to left ventricular function parameters: A comparison with positron emission tomography. J. Schwitter, G.K. von Schulthess, S. Kneifel, T. deMarco, M. Ciopor Jörg, H. Arheden, S. Rühm, K. Stumpe, A. Buck, T.F. Lüscher, W.W. Parmley, C.B. Higgins. Circulation. 2000; 101:2696-702.

OR-334 Obestiy is associated with tissue-specific activation of renal angiotensin converting enzyme in vivo. Evidence for a regulatory role of endothelin. M. Barton, R. Carmona, H. Morawitz, L.V. d1Uscio, W. Goettsch, H. Hillen, C. Haudenschild, J.E. Krieger, K. Münter, T. Lattmann, T.F. Lüscher, S. Shaw. Hypertension. 2000;35(1 Pt 2):329-36.

OR-335 Effects of atrial pacing on arterial and coronary sinus endothelin-1 levels in syndrome X. G.A. Lanza, T.F. Lüscher, V. Pasceri, S.G. Shaw, A. Buffon, A.S. Montenero, F. Crea, A. Maseri. Am J Cardiol. 1999;84:1187-91.

OR-336 Connective tissue growth factor induces apoptosis in human breast cancer cell line MCF-7. K. Hishikawa, B.S. Oemar, F.C. Tanner, T. Nakaki, T.F. Lüscher, T. Fujii. J Biochem Chem. 1999;274:37461-6.

OR-337 Endothelin-1 markedly potentiates human smooth muscle cell growth to PDGF: Effects of ETA and ETB recepotor blockade. Z. Yang, N. Krasnici, T.F. Lüscher. Circulation. 1999;100:5-8.

OR-338 Overexpression of connective tissue growth factor gene induces apoptosis in human aortic smooth muscle cells. K. Hishikawa, B.S. Oemar, F.C. Tanner, T. Nakaki, T. Fujii, T.F. Lüscher. Circulation. 1999;100:2108-12.

OR-339 Effect of Ox-LDL on endothelium-dependent response in pig ciliary artery: Prevention by an ETA-antagonist. P. Zhu, E.S. Dettmann, T.J. Resink, T.F. Lüscher, A.J. Flammer, I.O. Haefliger. Invest Ophthalmol Vis Sci. 1999;40:1015-20.

OR-340 Endothelial dysfunction in acute renal failure: Role of endothelin-1. F. Ruschitzka, S. Shaw, G. Noll, M. Barton, T.F. Lüscher. J Amer Soc Nephrol. 1999;10:953-62.

Thomas F. Lüscher 29

OR-341 Coronary and peripheral artery remodeling in patients undrgoing PTCA: An intracoronary and transcutaneous ultrasound study. E. Delacrétaz, M. Fleisch, U. Kaufmann, T.F. Lüscher, H.R. Brunner, B. Meier, D. Hayoz. Cath Cardiovasc Diagn. 1999;48:12-17.

OR-342 Platelet-derived growth factor-induced vasodilatation in mesenteric resistance arteries by nitric oxide: Blunted response in hypertension. H. Takase, B.S. Oemar, M. Pech, T.F. Lüscher. J Cardiovasc Pharmacol. 1999;33:223-8.

OR-343 Accuracy of a new wrist cuff oscillometric blood pressure device: Comparisons with intra-arterial and mercury manometer measurements. S. Watson, R.R. Wenzel, C. di Matteo, B. Meier, T.F. Lüscher. Am J Hypertension. 1999;11:1469-74.

OR-344 I1-Imidazoline agonist moxonidine decreases sympathetic nerve activity and blood pressure in hypertension. R.R. Wenzel, L. Spieker, S. Qui, S. Shaw, B. Meier, T.F. Lüscher, G. Noll. Hypertension. 1998;32:1022-7.

OR-345 Propofol-induced relaxation of rat mesenteric arteries: Evidence for a cyclic GMP-mediated mechanism. R. Liu, M.G. Lang, T.F. Lüscher, M. Kaufmann. J Cardiovasc Pharmacol. 1998;32:709-13.

OR-346 Beta-adrenergic agonist-induced nitrite production in isolate ciliary processes. R. Liu, A.J. Flammer, T.F. Lüscher, I.O. Häfliger. Graefe’s Arch Clin Exp Ophthal. 1998;236:613-16.

OR-347 Endothelial vasoconstrictor prostanoids, vascular reactivity, and acute renal failure. F. Ruschitzka, S. Shaw, G. Noll, M. Barton, E. Schulz, G.A. Müller, T.F. Lüscher. Kidney Int. 1998;67:S199-201.

OR-348 Nitrate induced coronary vasodilatation: differential effects of sublingual application by capsule or spray. M. Pfister, C. Seiler, M. Fleisch, H. Göbel, T. F. Lüscher, B. Meier. Heart. 1998;80:365-9.

OR-349 Chronic blockade of nitric oxide-synthase and endothelin receptors during pregnancy in the rat: Effect on reactivity of the uterine artry in vitro. E. Wight, C.F. Küng, P. Moreau, H. Takase, T.F. Lüscher. J Soc Gynecol Invest. 1998;5:288-95.

OR-350 Chronic blockade of nitric oxide-synthase and endothelin receptors during pregnancy in the rat: Effect on pregnancy outcome. E. Wight, C.F. Küng, P. Moreau, H. Takase, T.F. Lüscher. J Soc Gynecol Invest. 1998;5:132-9.

OR-351 Endothelin-1 induces vasodilation in human skin by nociceptor fibres and release of nitric oxide. R.R. Wenzel, S. Zbinden, G. Noll, B. Meier, T.F. Lüscher. Br J Clin Pharmacol. 1998; 45:441-6.

OR-352 Reduced endothelial nitric oxide synthase expression and production in human atheroscle-rosis. B.S. Oemar, M.R. Tschudi, N. Godoy, V. Brovkovich, T. Malinski, T.F. Lüscher. Circulation. 1998;97:2494-8.

OR-353 Midazolam premedication improves tolerance of transesophageal echocardiography. B.C. Aeschbacher, M. Portner, M. Fluri, B. Meier, T.F. Lüscher. Am J Cardiol. 1998;81:1022-6.

OR-354 ETA receptor blockade prevents increased tissue endothelin-1, vascular hypertrophy, and endothelial dysfunction in salt-sensitive hypertension. M. Barton, L. d’Uscio, S. Shaw, P. Meyer, P. Moreau, T.F. Lüscher. Hypertension. 1998;31:499-504.

OR-355 Angiotensin II and insulin induce growth of ciliary artery smooth muscle: Effects of AT1/AT2 antagonists. R.K. Dubey, A.J. Flammer, T.F. Lüscher. Invest Ophthal Vis Sci. 1998;39:2067-75.

OR-356 Hemodynamic and coronary effects of the endothelin antagonists bosentan in patients with coronary artery disease. R.R. Wenzel, M. Fleisch, S. Shaw, G. Noll, U. Kaufmann, R. Schmitt, C.R. Jones, M. Clozel, B. Meier, T.F. Lüscher. Circulation. 1998;98:2235-40.

OR-357 Endothelin ETA receptor blockade restores NO-mediated endothelial function and inhibits atherosclerosis in apolipoprotein E-deficient mice. M. Barton, C.C. Haudenschild, L. d’Uscio, S. Shaw, K. Münter, T.F. Lüscher.Proc Natl Acad Sci USA. 1998;95:14367-72.

OR-358 Felodipine inhibits free-radical production by cytokines and glucose in human smooth muscle cells. K. Hishikawa, T.F. Lüscher. Hypertension. 1998;32:1011-15.

OR-359 Effect of chronic nitric oxide deficiency on angiotensin II-induced hypertrophy of rat basilar artery. P. Moreau, H. Takase, L. d’Uscio, T.F. Luscher. Stroke. 1998;29:1031-6.

OR-360 Tetrahydrobiopterin alters superoxide and nitric oxide release in prehypertensive rats. F. Co-sentino, S. Patton, L. d’Uscio, E.R. Werner, G. Werner-Felmayer, P. Moreau, T. Malinski, T.F. Lüscher. J Clin Invest. 1998;101:1530-7.

OR-361 Different proliferative properties of smooth muscle cells of human arteral and venous bypass vessels: Role of PDGF receptors, mitogen-activated kinase, and cyclin-dependent kinase inhibitors. Z. Yang, B.S. Oemar, T. Carrel, B. Kipfer, F. Julmy, T.F. Lüscher. Circulation. 1998;97:181-7.

Thomas F. Lüscher 30

OR-362 Structure and reactivity of small arteries in aging. P. Moreau, L. d’Uscio, T.F. Luscher. Cardiovasc Res. 1998;37:247-53.

OR-363 Alterations to the nitric oxide pathway in the spontaneously hypertensive rat. E. Nava, A.L. Farré, C. Moreno, S. Casado, P. Moreau, F. Cosentino, T.F. Lüscher. J Hypertension. 1998; 16:609-15.

OR-364 Losartan but not verapamil inhibits angiotensin II-induced tissue endothelin-1 increase: Role of blood pressure and endothelial function. L. d’Uscio, S. Shaw, M. Barton, T.F. Luscher. Hypertension. 1998;31:1305-10.

OR-365 Endothelium-independent relaxation and hyperpolarization to C-type natriuretic peptide in porcine coronary artery. M. Barton, J.L. Bény, L. d’Uscio, T. Wyss, G. Noll, T.F. Lüscher. J Cardiovasc Pharmacol. 1998;31:377-83.

OR-366 Differential modulation of the renal and myocardial endothelin system by angiotensin II in vivo. M. Barton, S. Shaw, L. d’Uscio, P. Moreau, T.F. Lüscher. J Cardiovasc Pharmacol. 1998;31(suppl. 1):265-8.

OR-367 Modulation of endothelin-1 induced contractions by magnesium/calcium in porcine ciliary artery. E.S. Dettmann, T.F. Lüscher, A.J. Flammer, I.O. Häfliger. Graefe’s Arch Clin Exp Ophthal. 1998;236:47-51.

OR-368 Pulsatile stretch stimulates superoxide production in human aortic endothelial cells. K. Hishikawa, T.F. Lüscher. Circulation. 1997;96:3610-16.

OR-369 Role of nitric oxide in the regulation of the mechanical properties of peripheral conduit arteries in humans. R. Ioannides, V. Richard, W.E. Haefeli, A. Benoist, L. Linder, T.F. Lüscher, C. Thuillez. Hypertension. 1997;30:1465-70.

OR-370 Relaxation by bradykinin in porcine ciliary artery: Role of nitric oxide and K+-channels. P. Zhu, J.L. Bény, A.J. Flammer, T.F. Lüscher, I.O. Häfliger. Invest Ophthal Vis Sci. 1997;38: 1761-7.

OR-371 Pulsatile stretch stimulates superoxide production and activates nuclear factor in hu-

man coronary smooth muscle. K. Hishikawa, B.S. Oemar, Z. Yang, T.F. Lüscher. Circ Res. 1997;81:797-803.

OR-372 Differential activation of cardiac and peripheral sympathetic nervous system by nifedipine: Role of pharmacokinetics. R.R. Wenzel, G. Allegranza, C. Binggeli, S. Shaw, P. Weidmann, T.F. Lüscher, G. Noll. J Amer Coll Cardiol. 1997;29:1607-14.

OR-373 Angiotensin II increases tissue endothelin and induces vascular hypertrophy in vivo: Reversal by ETA-receptor antagonist. P. Moreau, L.V. d'Uscio, S. Shaw, H. Takase, M. Barton, T.F. Lüscher. Circulation. 1997;96:1593-97.

OR-374 High glucose increases nitric oxide synthase expression and superoxide anion generation in human aortic endothelial cells. F. Cosentino, K. Hishikawa, Z.S. Katusic, T.F. Lüscher. Circulation. 1997;96:25-28.

OR-375 Anatomic heterogeneity of vascular aging: Role of nitric oxide and endothelin. M. Barton, L. d'Uschio, S. Shaw, P. Moreau, T.F. Lüscher. Hypertension. 1997;30:817-24.

OR-376 Quinaprilat induces arterial vasodilation mediated by nitric oxide in humans. W.E. Haefeli, L. Linder, T.F. Lüscher. Hypertension. 1997;30:912-17.

OR-377 Structure and function of small arteries in salt-induced hypertension: Effects of chronic ETA-receptor blockade. L.V. d'Uschio, M. Barton, S. Shaw, P. Moreau, T.F. Lüscher. Hypertension. 1997;30:905-11.

OR-378 Effects of chronic ETA-receptor blockade in angiotensin II-induced hypertension. L.V. d'Usch-io, P. Moreau, S. Shaw, H. Takase, M. Barton, T.F. Lüscher. Hypertension. 1997;29:435-41.

OR-379 Bi-modal effects of angiotensin II on migration of human and rat smooth muscle cells: Direct stimulation and indirect inhibition via transforming growth factor beta-1. G. Liu, E. Espinosa, B.S. Oemar, T.F. Lüscher. Arterioscl Thromb Vasc Biol. 1997;17:1251-7.

OR-380 Differential effects of captopril and nitrates on muscle sympathetic nerve activity in volunte-ers. G. Noll, R.R. Wenzel, S. de Marti, S. Shaw, T.F. Lüscher. Circulation. 1997;95:2286-92.

OR-381 Different effects of thrombin receptor activation on endothelium and smooth muscle cells of human coronary bypass vessels: Implications for venous bypass graft failure. Z. Yang, F. Ruschitzka, T.J. Rabelink, F. Julmy, G. Noll, H. Dolesal, U. Althaus, T.F. Lüscher. Circulation. 1997;95:1870-6.

OR-382 Human connective tissue growth factor is expressed in advanced atherosclerotic lesions. B.S. Oemar, A. Werner, J.M. Garnier, Do dai-Do, N. Godoy, M. Nauck, W. März, J. Rupp, M. Pech, T.F. Lüscher. Circulation. 1997;95:831-9.

OR-383 Blood pressure and vascular effects of endothelin blockade in chronic nitric oxide-deficient hypertension. P. Moreau, H. Takase, C.F. Küng, S. Shaw, T.F. Lüscher. Hypertension. 1997; 29:763-9.

Thomas F. Lüscher 31

OR-384 Tetrahydrobiopterin restores endothelial function in hypercholesteremia. E. Stroes, J. Kastelein, F. Cosentino, W. Erkelens, R. Wever, H. Koomans, T. F. Lüscher, T. Rabelink. J Clin Invest. 1997;99:41-6.

OR-385 Cyclosporin A increases nitric oxide activity in vivo. E.S.G. Stroes, T.F. Lüscher, F.G. de Groot, H.A. Koomans, T.J. Rabelink. Hypertension. 1997;29:570-5.

OR-386 Endothelium-derived vasoconstrictor prostanoids modulate contractions to acetylcholine and angiotensin II in mesenteric resistance arteries of ren-2 transgenic rats. G. Noll, M. Lang, M.R. Tschudi, D. Ganten, T.F. Lüscher. Am J Physiol. 1997;272 (1 Pt 2):H493-500.

OR-387 Effect of dipyridamole on vascular responses of porcine ciliary arteries. P. Meyer, A.J. Flammer, T.F. Lüscher. Curr Eye Res. 1996;15:387-93.

OR-388 Percutaneous transluminal coronary angioplasty through 5 french diagnostic catheters. Gara-chamani, U. Kaufmann, M. Fleisch, B.J. Meyer, T.F. Lüscher, B. Meier. J Invas Cardiol. 1996; 6:433-7.

OR-389 Effect of pre-treatment with transdermal glyceryl trinitrate in myocardial ischemia during coro-nary angioplasty. S. Ramamurthy, V. Mehan, U. Kaufmann, V. Verin, T.F. Lüscher, B. Meier. Heart. 1996;6:471-6.

OR-390 Low-dose heparin for routine coronary angioplasty and stenting.J. Vainer, M. Fleisch, P. Gun-nes, S. Ramamurthy, A. Grachemani, U.P. Kaufmann, B.J. Meyer, T.F. Lüscher, B. Meier. Am J Cardiol. 1996;78:964-6.

OR-391 Effect of age on kinetics of nitric oxide release in rat aorta and pulmonary artery. M.R. Tschu-di, M. Barton, F. Cosentino, P. Moreau, G. Noll, T. Malinski, T.F. Lüscher. J Clin Invest. 1996; 98:899-905.

OR-392 17ß-oestradiol inhibits proliferation and migration of human vascular smooth muscle cells: Si-milar effects in cells from post-menopausal females and in males. Do dai-Do, E. Espinosa, G. Liu, T.J. Rabelink, F. Julmy, Z. Yang, F. Mahler, T.F. Lüscher. Cardiovasc Res. 1996;92:980-5.

OR-393 Effect of endothelin antagonists on the responses to prostanoid endothelium-derived contrac-ting factor. P. Moreau, H. Takase, T.F. Lüscher. Brit J Pharmacol. 1996;118:1429-32.

OR-394 17ß-oestradiol and smooth muscle cell proliferation in aortic cells of male and female rats. E. Espinosa, B.S. Oemar, T.F. Lüscher. Biochem Biophys Res Comm. 1996;221:8-14.

OR-395 Angiotensin-converting enzyme inhibition with quinapril improves endothelial vasomotor dys-function in patients with coronary artery disease: The TREND (Trial on reversing endothelial dysfunction) study. J.G.B. Mancini, G.C. Henry, C. Macaya, B.J. O'Neill, A.L. Pucillo, R.G. Carere, T.J. Wargovich, H. Mudra, T.F. Lüscher, M.I. Klibaner, H.E. Haber, A.C.G. Uprichard, C.J. Pepine, B. Pitt. Circulation. 1996;94:258-65.

OR-396 Endothelin-1-induced release of thromboxane A2 increases the vasoconstrictor effect of endothelin-1 in postischemic reperfused rat hearts. C.E. Zaugg, P. Zhu, P. Hornstein, D. Simper, T.F. Lüscher, P.R. Allegrini, P.T. Buser. Circulation. 1996;94:742-7.

OR-397 Endothelin and calcium antagonists in the skin microcirculation of patients with coronary artery disease. R.R. Wenzel, N. Duthiers, G. Noll, J. Bucher, U. Kaufmann, T.F. Lüscher. Circulation. 1996;94:316-22.

OR-398 Increased activation of sympathetic nervous system and endothelin by mental stress in normotensive offspring of hypertensive parents. G. Noll, R.R. Wenzel, M. Schneider, V. Oesch, C. Binggeli, S. Shaw, P. Weidmann, T.F. Lüscher. Circulation. 1996;93:866-9.

OR-399 Antihypertensive therapy prevents endothelial dysfunction in chronic nitric oxide deficiency: Effect of Verapamil and Trandolapril. H. Takase, P. Moreau, L. d'Uscio, T.F. Lüscher. Hypertension. 1996;27:25-31.

OR-400 Direct in situ measurement of nitric oxide in mesenteric resistance arteries: Increased decomposition by superoxide in hypertension. M.R. Tschudi, S. Mesaros, T.F. Lüscher, T. Malinski. Hypertension. 1996;27:32-5.

OR-401 Effect of cigarette smoking and nicotine on plasma endothelin-1 levels. S. Goerre, S. Staehli, S. Shaw, T.F. Lüscher. J Cardiovasc Pharmacol. 1995;26(Suppl. 3):236-8.

OR-402 Expression of nitric oxide synthase isoforms in the thyroid gland: Evidence for a role of nitric oxide in vascular control during goiter formation. I.M. Colin, E. Nava, D. Toussaint, D.M. Mai-ter, M.F. van Denhove, T.F. Lüscher, J.M. Ketelslegers, J.F. Denef, L. Jameson. Endocrino-logy. 1995;136:5283-90.

OR-403 Endothelin-1 plasma levels in normal-tension glaucoma: Abnormal response to postural changes. H.J. Kaiser, A.J. Flammer, M. Wenk, T.F. Lüscher. Clin Exp Ophthalmol. 1995; 233:484-8.

OR-404 Structure and function of the rat basilar artery during chronic nitric oxide synthase inhibition. P. Moreau, H. Takase, C.F. Küng, M.M. van Rooijen, T. Schaffner, T.F. Lüscher. Stroke.1995;26:1922-9.

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OR-405 L-NAME hypertension alters endothelial and smooth muscle function in rat aorta: Preventionby trandolapril and verapamil. C.F. Küng, P. Moreau, H. Takase, T.F. Lüscher. Hypertension. 1995;26:744-51.

OR-406 Role of basal and stimulated release of nitric oxide in the regulation of radial artery caliber in humans. R. Joannides, V. Richard, W.E. Haefeli, L. Linder, T.F. Lüscher, C. Thuillez. Hypertension. 1995;26:327-31.

OR-407 Differential effects of the calcium antagonist mibefradil in epicardial and intramyocardial coro-nary arteries. C.F. Küng, M.R. Tschudi, G. Noll, J.P. Clozel, T.F. Lüscher. J Cardiovasc Pharmacol. 1995;26:312-8.

OR-408 Effects of calcium channel blockers on the response to endothelin-1, bradykinin and sodium nitroprusside in porcine ciliary arteries. P. Meyer, M.G. Lang, A.J. Flammer, T.F. Lüscher. Exp Eye Res. 1995;60:505-10.

OR-409 Effect of aging and hypertension on contractility of resistance arteries: Modulation by endothelial factors. M.G. Lang, G. Noll, T.F. Lüscher. Am J Physiol. 1995;269:H837-44.

OR-410 ETA and ETB receptors mediate contraction to endothelin-1 in renal artery of aging spontaneously hypertensive rats: Effects of FR139317 and bosentan. B. Seo, T.F. Lüscher. Hypertension. 1995;25:501-6.

OR-411 Endothelin receptor subtypes in small arteries: Studies with FR139317 and bosentan. H. Takase, P. Moreau, T.F. Lüscher. Hypertension. 1995;25:739-43.

OR-412 Increased activity of constitutive nitric oxide synthase in cardiac endothelium in spontaneous hypertension. E. Nava, G. Noll, T.F. Lüscher. Circulation. 1995;91:2310-3.

OR-413 Local action of the renin angiotensin system in the porcine ophthalmic circulation: Effects of ACE-Inhibitors and angiotensin receptor antagonists. P. Meyer, A.J. Flammer, T.F. Lüscher. Invest Ophthalmol Vis Sci. 1995;36:555-62.

OR-414 Nitric oxide inhibits angiotensin II-induced migration of rat aortic smooth muscle cell. R.K. Dubey, E.K. Jackson, T.F. Lüscher. J Clin Invest. 1995;96:141-9.

OR-415 Age and hypertension differently affect coronary contractions to endothelin-1, serotonin and angiotensins. M.R. Tschudi, T.F. Lüscher. Circulation. 1995;91:2415-22.

OR-416 Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo. R. Joannides, W.E. Häfeli, L. Linder, V. Richard, H. Bakkali, C. Thuillez, T.F. Lüscher. Circulation. 1995;91:1314-9.

OR-417 Development of nitrate tolerance in human arteries and veins: Comparison of nitroglycerin and SPM-5185. U. Arnet, Z. Yang, R. Siebenmann, L.K. von Segesser, M. Turina, P. Stulz, T.F. Lüscher. J Cardiovasc Pharmacol. 1995;26:401-6.

OR-418 Different mechanisms of endothelial dysfunction with aging and hypertension in rat aorta. C.F. Küng, T.F. Lüscher. Hypertension. 1995;25:194-200.

OR-419 Endothelin-1 in pulmonary hypertension associated with high altitude exposure. S. Goerre, M. Wenk, P. Bärtsch, T.F. Lüscher, F. Niroomand, E. Hohenhaus, O. Oelz, W.H. Reinhart. Circulation. 1995;91:359-64.

OR-420 Characterization of contractile endothelin and angiotensin receptors in human resistance arteries: Evidence for two endothelin and one angiotensin receptor. M. R. Tschudi, T. F. Lüscher. Biophys Biochem Res Commun. 1994;204:685-90.

OR-421 Endothelial dysfunction in aorta of the spontaneously hypertensive, stroke-prone rat: Effects of therapy with verapamil and trandolapril alone and in combination. D. Novosel, M.G. Lang, G. Noll, T.F. Lüscher. J Cardiovasc Pharmacol. 1994;24:979-85.

OR-422 Angiotensin blockade or calcium antagonist improve endothelial dysfunction in hypertension: Studies in perfused mesenteric resistance arteries. Y. Dohi, L. Criscione, K. Pfeiffer, T.F. Lüscher. J Cardiovasc Pharmacol. 1994;24:372-9.

OR-423 Endothelin Receptor Antagonists Inhibit Endothelin in Human Skin Microcirculation. (Rapid Communication) R. R. Wenzel, G. Noll, T.F. Lüscher. Hypertension. 1994;23:581-6.

OR-424 Alterations in coronary artery vascular reactivity of hypertensive ren-2 transgenic rats. M.R. Tschudi, G. Noll, U. Arnet, D. Novosel, D. Ganten, T.F. Lüscher. Circulation.1994;89:2780-6.

www.rbht.nhs.uk @RBandH

To

Professor Jereon Bax, FESC

ESC Immediate Past President

Chairman of the Nominating Committee

European Heart House

2035, Route des Colles

06903 Sophia Antipolis Cedex, France

<fpinto@icvl.pt>

London, September 26, 2017

Application for the Position of Secretay/Treasurer of the European Society of Cardiology

Dear Professor Bax, dear Jereon,

With this letter; I would like to apply for the position of secretary/treasurer of the European Society of

Cardiology for the period of 2020 – 2022.

As you know, I proudly served the European Society of Cardiology for many years, first as chairman of the

then Working Group on Coronary Circulation, then as chairman of the program committee of the Annual

Congresses in Berlin and Munich, then as Vice President of the Working Groups under the leadership of

Jean-Pierre Bassand when we created the ESC Associations and in the last years as editor-in-chief of the

European Heart Journal. Furthermore, together with others I did and continue to edit the ESC Textbook of

Cardiovascular Medicine together with John A. Camm, Gerald Maurer and Patrick W. Serruys now in its 3rd

edition, this time with a huge electronic database of more than 800 chapters which is now part of the new

membership scheme, later this year.

I am highly motivated to further serve the European Society of Cardiology in a new position for the period of

2020 – 2022. The position as secretary/treasurer is particularly attractive to me as in this period of un-

certainty about funding policies and regulations, the financial aspects and good governance of this fine

society are even more important than they were in the past. I am convinced that with my longstading

experience as chairman and manager of several large University Heart Centers with a very sizable yearly

budgets, I will bring the necessary competence for this position. Furthermore, my deep insights into the

organization and working of the European Society of Cardiology thanks to my various commitments over

the last two decades, would be of invaluable help as well.

I already implemented my vision to bring the European Society of Cardiology closer together and to further

strengthen its brand as a source of high quality education and excellent science as chairman of the Publi-

cations Committee where I created the ESC Journal Family as a functional unit, first by implementing a

Royal Brompton Hospital

Sydney Street

London

SW3 6NP

Professor Thomas F. Lüscher, FRCP

Director of Research, Education &

Development

Consultant Cardiologist

T: +44 (0)20 7352 8121

F: +44 (0)20 7351 8473

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manuscript transfer network and more recently, as part of a comprehensive branding strategy of the

society, by the introduction of a coherent design and appearance of all our ESC journals. Furthermore, I

invested in quality and brought the ESC Journals to the forefront internationally and enjoyed an enormous

growth in impact, visibility and recognition. Similarly, we aligned together with the Education Committee the

European Heart Journal, the ESC Guidelines and the ESCel plattform in an attempt to make the ESC

Guidelines shorter and more readable and link them the new ESC Textbook to create a unique educational

ressource. This integration of our most successful products besides the Annual Congress appears crucial

to me and hence I would envisage to persue this strategy further in other aspects of the society with the

members of the management committee in the new position as secretary/treasurer.

Importantly, the financial ressources of the European Society of Cardiology will have to be further

broadened in the new regulatory environement; the new membership scheme that we introduced during

your presidency, where the ESC Journals and the ESC Textbook are integral parts, is a first step, but

others must follow. Specifically, I would envisage a separate educational foundation which would be

supported by pharma and device companies to allow for a politically acceptable sponsoring strategy which

allows to separate interest in a way compatible with todays requirements.

Finally, I would help to support our research programmes based on my experience as a cardiovascular

scientists and leader of a large research institution, the Center for Molecular Cardiology. In particular, I

would suggest to focus the registry programmes on a few, but important topics allowing for data quality as

is expected today. The support of young clinicians and scientists is another important issue that should be

expanded as much as is possible to create a network of the next generation of experienced and loyal

members of the European Society of Cardiology.

Please find enclosed my short as well as an extended CV with the list of publications, support letters of the

Swiss as well as the Austrian Society of Cardiology, my declaration of interest and the signed code of

conduct as required.

Thomas F. Lüscher, FESC, FRCP Professor of Cardiology Imperial College and University of Zurich

Enclosure: CV short CV with list of selected publications Declaration-of-Interest Signed Code-of-Conduct Support letter of the Swiss Society of Cardiology Support letter of the Austrian Society of Cardiology

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