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Heart, Lung and Circulation Abstracts S632008;17S:S1–S209

arrhythmias in cardiomyopathy and may help to betterdefine those at risk of SCD.

doi:10.1016/j.hlc.2008.05.143

143True Bicuspid Aortic Valves are Rare Compared withFunctionally Bicuspid Aortic Valves

Samuel Hayman ∗, Geraldine Wright, Cathy West, DarrylBurstow, Gregory M. Scalia

The Prince Charles Hospital, Chermside, Qld, Australia

Background: Bicuspid aortic valves (BAV) are thecommonest congenital heart defect with significant mor-bidity and actuarial mortality burden. Two fundamentalanatomic variants exist; True BAV with two symmet-ric leaflets and two sinuses of Valsalva, Functional BAVwith three morphologic leaflets (two of which are fused)and three sinuses of Valsalva. The prevalence, associateddefects (e.g. coarctation) and prognostic implications arereviewed.Methods: Data from 164 patients with confirmed BAV asidentified from a database search from 2005 to 2007 wereanalysed. BAVs were classified as True or Functional andcommissure orientation and leaflet/cusp fusion recorded.Haemodynamic abnormalities were defined as stenotic,regurgitant, mixed or neither. Coarctation was assessedbv

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144Light Activity Central End Systolic Pressure indepen-dently Predicts Left Ventricular Systolic Function inPatients with a Hypertensive Response to Exercise

James E. Sharman ∗, James L. Hare, Scott B. Thomas, RodelLeano, Thomas H. Marwick

The University of Queensland, Brisbane, Queensland, Australia

Background: The gold standard measure of blood pressure(BP) control is 24 h ambulatory BP monitoring (24 ABPM).However, 24 ABPM does not account for differences incentral BP that may occur between people with similarbrachial BP. We sought to determine if light activity centralBP was independently associated with left ventricular (LV)systolic function.Methods: The population comprised 60 patients (aged55 ± 9 years) without cardiac disease but with a hyper-tensive response to exercise. All patients underwent 24ABPM, and LV systolic function was assessed by conven-tional echocardiography (ejection fraction; EF) as well astissue Doppler imaging (strain and peak systolic tissuevelocity [Sm]). Central BP and pressure waveform indiceswere estimated by radial applanation tonometry at restand during light cycling (approximately 4 min at 60% ofmaximal heart rate).Results: Light activity central end systolic pressure (ESP)was significantly associated with Strain (r = 0.49; p < 0.001;FSabEbd(CsmDa

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y continuous wave Doppler from the arch suprasternaliew.

esults: Of the 164 patients, 72% were male (n = 118). Onlysmall number (9%) of cases were True bicuspid valves.he remaining (91%) were Functional BAVs. These con-isted most commonly of fusion right–left coronary cusps70%), right-non (18%) and left-non (12%). Haemodynam-cally, isolated aortic regurgitation was the commonestesion (43%) with 17% having mixed regurgitation andtenosis. Isolated stenosis was present in 23% (averageeak gradient 63 mmHg) and 17% had normal haemody-amics.onclusions: True bicuspid aortic valves are very rare.unctional bicuspid valves involving most frequentlyusion of the left and right coronary cusps are commonnd are usually regurgitant or mixed regurgitant/stenotic.

oi:10.1016/j.hlc.2008.05.144

igure), but not EF or Sm (r < 0.21; p > 0.13 for both). Fortrain, weaker associations were found with 24 ABPMnd resting mean arterial pressure (r = 0.32; p < 0.05 foroth). After correcting for multiple factors (LV mass index,F, Sm, age, gender, 24 ABPM, resting or light exerciserachial BP), light activity central ESP remained indepen-ently associated with strain, accounting for 24% varianceβ = 0.51; p < 0.01).onclusions: Light activity central ESP correlates more

trongly with LV systolic function than traditional loadingeasures, including the current gold standard, 24 ABPM.ata from this new non-invasive technique is rapidly

cquired and may be clinically applied in the future.

oi:10.1016/j.hlc.2008.05.145