turning data science into a reality with tibco spotfire · 2016-11-08 · turning data science into...
TRANSCRIPT
Turning Data Science
into a reality with TIBCO Spotfire®
Eduardo Gonzalez-Couto, Ph.D. Product Manager, PerkinElmer Informatics
Basel, 3rd November 2016
2
Safe Harbor Statement
• This document shows current intentions regarding product features,
behavior, schedules and support; these intentions may change without
notice as we respond to customer requirements.
• Any unreleased products, services or features referenced herein are
not currently available and may not be delivered on time or at all.
Customers who purchase PerkinElmer informatics applications should
make their purchase decisions based upon products, features, and
services that are currently available.
New Informatics for New Data Science The pace of life science data generation
and the complexity of the generated data
is outperforming existing informatics solutions
4
Cloud-based data store and analytics platform designed
for today’s and tomorrow’s life science needs. Enabling
user experience around TIBCO Spotfire supports wide
range of data processing workflows and applications.
PerkinElmer Signals™
Domain-specific entity model and ontologies
Machine learning for data normalization and mapping
Signals App Store with scientific applications
Intelligent
Big data technology foundation - Spark & HDFS
Cloud-scale, elastic SaaS deployment
Automated workflows with Automation Services
Scalable
User friendly scientific applications in TIBCO Spotfire
User-driven, self-service access to all relevant data
Collaboration within and across the firewall
Enabling
Introducing PerkinElmer Signals™
PerkinElmer Signals for Translational Break Down The Firewall Between Data And Discovery
6
PerkinElmer’s Vision of Translational Medicine
Multiplex ELISA
NGS
GEA
Quantitative
Pathology
IHC
Fusion CNV
Getting the right drug to the right patient at the right time
Stratified Patient Population Patient Population
7
From Translational Medicine to Personalized Medicine
Multiplex ELISA
NGS
GEA
Quantitative
Pathology
IHC
Fusion CNV
Getting the right drug to the right patient at the right time
Precise diagnosis
Targeted Therapy
8
Translational Medicine Workflows
Raw Data
Select Processed
Data
QA/QC
Results
Review Secondary
Analysis Select Clinical
Subject & Samples
Secondary
Analysis
Data
Processing
Select Secondary
Results
Perform Integrated
Analysis
Bioinformatician / Data Scientist
Focuses on single experiment
and starts with an instrument run
Translational Scientist
Starts with a scientific hypothesis
and scientific Entities
PerkinElmer Signals Annotated Raw Data
Annotated Processed Data
Derived Data
9
PerkinElmer Signals for Translational Visual Analytics and the Cloud - video
Translational Video
PerkinElmer Signals for Screening How Big Data Becomes Breakthrough Data
12
Extensible and configurable analytics applications to
TIBCO Spotfire. The Signals Apps Store for Screening
supports users to create configurable screening data
analytics workflows for a wide range of applications.
Signals App Store for Screening
Configurable and extensible; apps can be combined to
protocols; protocols can be saved and shared between
users; extension and configuration with custom apps
Flexible
Protocols can be run interactive or fully automated
using Automation Services; reporting apps for fully
integrated workflows
Automated
Intrinsic domain model awareness enables apps to
configure themselves and guide user through input
parameters selection
Intelligent
PerkinElmer Signals™ for Screening
Data Import and
Aggregation
Spotfire Templates
High Content Profiler
Curve Fitting
SAR
Real-time Analytics
Alerts, Reports,
Publish, Collaborate
Automated Workflow
13
System Components
These intentions may change without notice as we respond to customer requirements.
HCS HTS
SIGNALS for SCREENING Analysis, persistence and management of data generated by the instruments, Columbus, and Spotfire Apps and Protocols
COLUMBUS
OMERO 5.x
Manage image transfer
and analysis from
instrument to the cloud
HPC IMAGE ANALYSIS
Columbus leverages
compute clusters for
scalable image analysis
SPOTFIRE APP STORE
Interactive front-end for
protocol development,
analysis, and automation
SIGNALS PLATFORM
Built to support diverse screening platforms with domain models, archiving, permissions, etc.
SEARCH AND ADVANCED SCREENING ANALYTICS
Advanced search and cross assay/screen analytics
3rd PARTY IMAGE/DATA ANALYSIS
SOFTWARE
Matlab, ImageJ, CellProfiler etc.
14
PerkinElmer Signals for Screening Agile Visual Analytics - video
Screening Video
16
High Content Profiler for HCS and HTS
• Multivariate Statistics
◦ Normalization
◦ Outlier detection
◦ Feature selection
◦ Hit selection & stratification
• Guided Spotfire Workflows
◦ Cell and well level analysis
◦ Automated, standardized analysis
◦ Highly interactive visualization
◦ Scientifically validated
• Image Rendering
◦ Hypothesis testing
◦ Result validation
17
High Content Profiler for HCS and HTS
• Multivariate Statistics
◦ Normalization
◦ Outlier detection
◦ Feature selection
◦ Hit selection & stratification
• Guided Spotfire Workflows
◦ Cell and well level analysis
◦ Automated, standardized analysis
◦ Highly interactive visualization
◦ Scientifically validated
• Image Rendering
◦ Hypothesis testing
◦ Result validation
18
High Content Profiler for HCS and HTS
• This summer…
19
High Content Profiler for HCS and HTS
• This summer…
20
High Content Profiler for HCS and HTS
• This summer…
21
PerkinElmer Imaging Informatics Roadmap
Signals for
Screening
2016
Columbus
Profiler
Signals
inForm
Q-Path Spotfire
In-Vivo, etc.
Signals for
Imaging
…
Scre
en
ing
Pa
tho
logy
In-V
ivo
22
Clinical Application Framework Looking Ahead: Combining Workflow,
Holistic Data Provisioning, and Advanced Analytics
23
Clinical/Medical Data Review
Safety and PV Risk-Based Monitoring
Clinical Operations
Spotfire in Clinical Development
Health Outcomes & RWE
24
PerkinElmer Clinical Application Framework “One Stop Shop” for Clinical Data insights
25
New Informatics for New Data Science Covering life science needs
26
PerkinElmer and TIBCO Strategic Partnership
Bringing Science back into the Spotfire platform
Chemistry and Structures Gene Expression
SAR Drug Dose Response
