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Towards quantitative magnetic resonance assessment in parenchymal liver disease

Runge, J.H.

Link to publication

Citation for published version (APA):Runge, J. H. (2015). Towards quantitative magnetic resonance assessment in parenchymal liver disease.

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Download date: 13 Dec 2020

Towards quantitative magnetic resonance assessment in parenchymal liver disease

To

ward

s qu

antitative m

agn

etic reson

ance assessm

ent in

paren

chym

al liver disease

Jurgen Henk Runge

Jurgen Henk Runge

Towards quantitative magnetic resonance assessment in parenchymal liver disease

Jurgen Henk Runge

Towards quantitative magnetic resonance assessment in parenchymal liver disease

Thesis

2015 © J.H. Runge, Amsterdam, the Netherlands

The copyright of the papers that have been published has been transferred to the

publishers of the respective journals. No part of this thesis may be reproduced,

stored, or transmitted in any form or by any means, without prior permission of the

author or the aforementioned publishers.

Printing of this thesis was financially supported by:

Department of Radiology, Academic Medical Center, Amsterdam, the Netherlands

University of Amsterdam, Amsterdam, the Netherlands

Paranimfen: Robert Hemke, Thierry Nicolas Boellaard

Cover: Rik August Runge

Layout: Jurgen Henk Runge

Printed by: Printservice Ede

ISBN: 978-94-91602-30-6

Towards quantitative magnetic resonance assessment in parenchymal liver disease

ACADEMISCH PROEFSCHRIFT

ter verkrijging van de graad van doctoraan de Universiteit van Amsterdamop gezag van de Rector Magnificusprof. dr. D.C. van den Boomten overstaan van een door het college voor promotiesingestelde commissie,in het openbaar te verdedigen in de Agnietenkapelop vrijdag 13 februari 2015, te 10:00 uur

door

Jurgen Henk Rungegeboren te Mook en Middelaar

Promotiecommissie

Promotores: Prof. dr. J. Stoker Prof. dr. U.H.W. Beuers

Copromotor: Dr. ir. A.J. Nederveen

Overige leden: Prof. dr. O.M. van Delden Prof. dr. J.S. Laméris Prof. dr. P.L.M. Jansen Prof. dr. F.J.W. ten Kate Prof. dr. P.R. Luijten Dr. R.J. de Knegt

Faculteit der Geneeskunde

Aan Annerien

Table of contents

General introduction and outline of thesis

Measuring liver triglyceride content in mice: non-invasive magnetic resonance methods as an alternative to histopathologyMagnetic Resonance Materials in Physics, Biology and Medicine.

2014 Aug;27(4):317-327

Quantitative determination of liver triglyceride levels with 3T 1H-MR Spectroscopy in mice with moderately elevated liver fat contentAcademic Radiology. 2014 Nov;21(11):1446-1454

Comparison of interobserver agreement of magnetic resonance elas-tography with histopathological staging of liver fibrosisAbdominal Imaging. 2014 Apr;39(2):283-290

Clinical MR liver iron assessment using Gandon, R2 and R2*: success rates and interobserver agreementSubmitted

A comparison of single voxel ISIS and 2D 31P-MRSI of the liver at 3T and 7T in healthy volunteers: SNR-boosted T2-weighted 7T AMESING MRSI allows metabolic mappingSubmitted

SummaryConclusionsImplications and future research

SamenvattingConclusiesImplicaties en toekomstig onderzoek

List of abbreviationsList of publicationsPortfolioDankwoordCurriculum vitae

9

25

45

63

77

99

117

129

139

Chapter 1

Chapter 2

Chapter 3

Chapter 4

Chapter 5

Chapter 6

Chapter 7

Chapter 8

Appendix