dfzljdn9uc3pi.cloudfront.net · web viewtable s5 kegg pathway enrichment for differentially...
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Figure S1 Flowchart for bioinformatics analysis of datasets from TCGA, GTEx and GEO.
Figure S2 Heat map analysis of differentially expressed lncRNAs (A), miRNAs (B), and genes (C). The horizontal axis denoted the cluster analysis of each sample. The longitudinal axis indicated the cluster analysis of lncRNA, miRNA, or gene. High- or low-relative expression is displayed as a red or blue strip, respectively.
Figure S3 Results from the principal component analysis for integrated microarray studies downloaded from the GEO dataset. Two-dimensional plots of normal and tumor groups with the top two principal components. Horizontal and vertical axes represent the distribution of each sample within PCA1 and PCA2 respectively. PCA1: principle component 1; PCA2: principal component 2.
Figure S4 Survival analysis of miRNAs and mRNAs in ceRNA network.
Kaplan–Meier analysis of differentially expressed miRNAs(A), and mRNAs(B) in ceRNA network by comparing the higher(red) and lower(green) expressions with overall survival outcomes for patients with HGSOC. P-value set for this analysis is less than 0.05.
The bottom part shows the threshold set by R package. Horizontal axis: the expression level of a certain gene, Vertical axis: standardized Log-Rank statistic. Dotted line: the cutoff value for gene expression.
Figure S5 Correlation of lncRNAs, LINC00858 (A), FTX (B), and LINC00665 (C), expression with infiltrating levels of tumor purity (first column) and lymphocyte infiltration level in high-grade serous ovarian cancer.
Table S5 KEGG pathway enrichment for differentially expressed genes
ID
Description
P value
Count
Regulation
hsa04110
Cell cycle
8.01E-05
35
upregulation
hsa03030
DNA replication
0.00181
12
upregulation
hsa03010
Ribosome
0.002645
15
upregulation
hsa01230
Biosynthesis of amino acids
0.015409
14
upregulation
hsa00190
Oxidative phosphorylation
0.023202
13
upregulation
hsa03440
Homologous recombination
0.026669
10
upregulation
hsa04060
Cytokine-cytokine receptor interaction
0.034683
29
upregulation
hsa04218
Cellular senescence
0.035041
27
upregulation
hsa04657
IL-17 signaling pathway
0.049274
11
upregulation
hsa04022
cGMP-PKG signaling pathway
5.29E-05
17
downregulation
hsa04610
Complement and coagulation cascades
0.000681
12
downregulation
hsa04072
Phospholipase D signaling pathway
0.014802
16
downregulation
hsa04350
TGF-beta signaling pathway
0.021213
11
downregulation
hsa04140
Autophagy - animal
0.023443
13
downregulation
hsa04014
Ras signaling pathway
0.032845
21
downregulation
hsa04371
Apelin signaling pathway
0.038948
14
downregulation
hsa04630
JAK-STAT signaling pathway
0.038948
14
downregulation
Table S6 GO biological process for differentially expressed genes
ID
Description
Count
P value
Regulation
GO:0048285
organelle fission
93
5.12E-15
upregulation
GO:0007059
chromosome segregation
91
9.76E-21
upregulation
GO:0000280
nuclear division
90
2.27E-16
upregulation
GO:0098813
nuclear chromosome segregation
81
1.26E-19
upregulation
GO:0071103
DNA conformation change
73
2.27E-16
upregulation
GO:0000819
sister chromatid segregation
70
1.26E-19
upregulation
GO:0140014
mitotic nuclear division
68
1.51E-15
upregulation
GO:1901987
regulation of cell cycle phase transition
62
0.000873164
upregulation
GO:0006260
DNA replication
59
6.85E-09
upregulation
GO:0006323
DNA packaging
56
5.99E-14
upregulation
GO:0045787
positive regulation of cell cycle
56
0.000233921
upregulation
GO:0051052
regulation of DNA metabolic process
56
0.000976283
upregulation
GO:1901990
regulation of mitotic cell cycle phase transition
55
0.005152821
upregulation
GO:0048568
embryonic organ development
55
0.008049245
upregulation
GO:0009314
response to radiation
54
0.025804851
upregulation
GO:1901653
cellular response to peptide
38
0.029874989
downregulation
GO:0019216
regulation of lipid metabolic process
38
0.042661545
downregulation
GO:0007178
transmembrane receptor protein serine/threonine kinase signaling pathway
36
0.042661545
downregulation
GO:0071375
cellular response to peptide hormone stimulus
34
0.042661545
downregulation
GO:0071383
cellular response to steroid hormone stimulus
33
0.01133506
downregulation
GO:0061448
connective tissue development
29
0.029528939
downregulation
GO:0009755
hormone-mediated signaling pathway
27
0.047752345
downregulation
GO:0043401
steroid hormone mediated signaling pathway
26
0.014684241
downregulation
GO:0010517
regulation of phospholipase activity
11
0.049805782
downregulation
GO:0097035
regulation of membrane lipid distribution
9
0.044563787
downregulation
GO:0030318
melanocyte differentiation
8
0.014684241
downregulation
GO:0045332
phospholipid translocation
8
0.014684241
downregulation
GO:0034204
lipid translocation
8
0.016669149
downregulation
GO:0048070
regulation of developmental pigmentation
6
0.042661545
downregulation
GO:0032429
regulation of phospholipase A2 activity
5
0.035988155
downregulation
Table S7 OS-associated differentially expressed genes
Gene type
Regulation
Gene name
DEG
UP
CLDN6HTR3AFOLR1CLDN16SLC34A2MMP7SCGB2A1SOX11CRABP1CAPN13DPEP3C6orf223VTCN1PHOX2ACDKN2ACXCL17XAGE2PTH2RNXPH4KLK5FAM181ASMPDL3BILDR1AOC1SMIM22TMPRSS3KRT7LIN28BAQP5EPCAMPRSS21CLDN9GJB1LCN2ROS1GPR12LAMP3HIST1H3BFOXA2NOTUMSCGB1D2TMPRSS4GLYATL2FOXJ1HOXB8CACNG4CD24FOXQ1XDHGLDCKRT23MAL2SSTAP1M2PBKMMP1PADI3ETV4PKHD1C1orf210GMNCCDC20GPR39IGFL1PRSS8E2F8ESRP1LRRC55CYP24A1UCP2INAVACRABP2KCNS1FABP6LYPD6BSPDEFKDF1RAB25NEK2TACSTD2EHFELF3GRHL2PDE6GPCLAFC1orf116CEP55SYCE3HIST1H3CLGSNCKAP2LNEIL3BIRC5SKA3TTKEPHX4DGKKBIKSP8GPR19ST14MISPCCNA1RDM1CPMELKC2orf54MYH14PPP1R14DGJA8EDN2SLC35D3PRSS22KLHL14FAM83HBSPRYACY3AQP6METTL7BRRM2PKP3LAD1CYP2F1HMGA1C6orf132RIPK4CCL20MAJINNECTIN4FRMPD1RASAL1SAPCD2UGT8CCL25APELASERINC2LGALS14ADAMDEC1CDH18ASF1BFOXN1KLHDC7BSHISA9MACC1CDH6GAL3ST3SGO1FAM83EHES2DIRAS2POU2F3SPP1SLAMF9TK1GJB3FAM111BCLDN19C15orf48CDH12DCDC2KIF4ASPINT1E2F2OASLTFAP2ACHST6VPREB3GSDMCLRRC15TMC4ZIC3HIST1H2AJBCL2L14PYYUBE2TGABRPS100A14CRB3CCNE1LRRC8EHOXD1HRKSCNN1ATFAP2CDYDC2NCAPHRIPPLY3PPP1R14CSKAP1S100A2CYP1A2TGM7DLX4NPWKRT86NRTNCLSPNSLCO6A1OVOL1ATP10BESCO2CCL7SLC4A11IFNL1ESPNSMKR1DTLFUT3CCNB2FOXE3HOXB4VSTM2LCDC45TMPRSS13GALPNLRP7GRHL3ECT2ASRGL1CRTAC1EXO1ERFEIFI27PLS1COMPASCL2CELSR1HMGA2KIF18APRRG2HAPLN1EVA1AERBB3DNAAF3TTC39AASPMLMX1BIL4I1DRC1SLITRK1HIST1H2ALCKS2PKMYT1SPXLPAR3KIF1ACDCA5BICDL2NEURL3DAND5HIST1H2BHCDK1ESPL1PRR7CENPAATP1A3CENPFRUNX3PADI2CACNA1BTPD52CDKN3VAV3ISG15BFSP2SUCNR1TBX20ARL4CCENPMOAS2P2RY6NDC80CLDN10HIST1H2ABRAD51AP1CCR3CELSR2CYP4F11PQLC2LPAQR4CCL17ZNF560C2orf88GABRQCAMK2N2TTC22MIOXCHRNA9LEMD1BLMROPN1LTMEM61HSH2DKPNA2POLQFAT2MECOMSBK1F12CHODLLMX1AELF5SERPINB10RSPH6AELOVL3SPTBN2LMO1TLCD1HIST1H2BBTMEM45BST6GALNAC2NUP210VNN3ARHGAP11AKCNK15NOGPROM2CCNB1CDCA7PRAMEZWINTRPL39LPLAC1DLEU7GALNT6CCDC187SRD5A3CHRNA6POC1APHOSPHO1CA2HS3ST4CXCL13TRIP13RSPO4MAD2L1PLK1L1CAMMEOX1SPON1RCAN3MAPK15PCP2LAPTM4BADTRPMFAP5SH2D4BABHD11HMGB3SLAMF7SLC27A2HIST1H3ABAIAP2L1RAB39BPRKCGCENPKKCNN4SLC2A1OR1Q1CD3GIGFBPL1KCNJ16UNC93B1CSMD2MPZL2FGF8TNFRSF12AONECUT3CCDC167THEM6CCND1FAM155BKAZALD1TACC3SYNE4XPR1DLGAP3USP18KRTCAP3SULT1C2ACRV1HUNKIL32PMCHALPK2GRHL1C3orf80P2RY2PITX3BTLAAPOA1C1orf87SEMA3FFGF23LARGE2CXCR4VWDESHCBP1TEKT2ESM1TNFAIP6SEMA5BRHPN1CKS1BITGB8BARX1TRPV4KCNQ3NCEH1GALNT3MZB1OCIAD2ZBTB42ZDHHC12IL21RDLL3MARVELD3RAB11FIP4SYTL1ABCA4SLC6A12MREGTRIB1DHCR24IDH2MUC4NDUFB9JPT1NKAIN1SHISA8BACE2HPDLCATSPER1PPP1R14BPRR18VANGL1C2orf15GNG13EXOSC4ANKFN1FAM178BGPT2CLEC5AMPP7EXPH5LACTB2TDRKHLRRC8DCD207MPZL3C9orf16PSENENORC6KLK4TLR10ORC1IL27RAANKRD45INHBBALG3ST6GALNAC5CXorf58RYR1DSC1PYCR1UBALD2NOX4WDR62TRIM59PCDH7SORT1HIST1H2BCAK7NCAPD2LYPLA1E2F3ALDH3A1GRIN2DRMI2MYCNFCGR1AMYEF2GINS2DRD2NME1CHAC2PCDH19HTR1DERCC6LBEND3RNASEH2AENKURSMC4C3orf67PAFAH1B3KIAA1549LCDK5PITPNM1ULBP1CLEC1BPROSER2SLC25A10PNPMS4A8C2orf50TESMRPL47MRPL14MAP4K1TRPM1SLC39A4GINS4COL13A1SPC24MRPL13SLC7A1JUPKCTD1USH1CGPR84GIPC1GAPDHMRPL3STOX1SYNGR2PCNALSM4DPP3AHNAK2RAB3DAPLNREPOPIL12AFUT8SYNGR3C20orf204MRPL15RTKNBAK1STRBPRGCCFAM171A2SLC50A1SLC39A11SOWAHAMCUR1MRPS12ATP6V0E2MAP7D2NRARPGDF9PIF1PTX3UPK2JPH1FEN1TSTA3PLA2G4FCRIP2PRC1DARS2TMEM19TRPM2SIX4PLD4E2F1H2AFXZNF165SORDCCDC58HDGFS100A13RAB26CRACR2BLRG1FAM166BCHRNA5PRKXTATDN1CENPLRBM38ULBP3TEAD4MEX3ASDHAF3CAPN12FMN1TONSLATF5PRELID1TPMTRASGEF1CUNC5BDSCC1AGBL5COA6LIN28APARS2C5orf22SLC38A1NETO2TRIB3NDC1PSMB2FBP2SLA2CFAP74CACNA1APYCR3ZNF93CHEK1HIST3H2ATECPLEKHF2TIMM17BCCDC160ZFP57MUC20MRPL12FZD2DPY30PPP4CMSH2CTLA4MTHFD2CCNA2FSD1ATP6V1FSNX31NDUFB11SLC38A4TMEM223NAA38SLC52A2CENPHMAP2K6LRGUKNUDT14PRKCDEXOSC5DYRK2RHNO1SUSD2TYMSCCDC34CACNG8SLC2A12ETV6TBCCMOCS3TIMM23MRPS15ATOH7CCR4DHFRCYC1DNMT3BCABP4YEATS4LRRIQ3RCN2RCC2SFMBT1PUF60CCDC169COPEPCDHA2TBC1D31PFKPENO1MGME1TNFRSF10AFAM81ADERL3ROMO1TPI1CHCHD3APBA2HMBSLLGL2KCNS3CLPBANKEF1PGAM5EPHA1FILIP1MFSD3FLAD1TBC1D7CCNB3MRPS18ATRIM47GMIPPNMA3PDE9ACBX2ZCRB1PRIM2RNF5NCAPG2SUV39H2CSE1LLSM2BTG3C5orf34KIF20BFIBPCDK2AP2HNRNPABGPR27FAM107APNCKPTGESBATF2ST3GAL6EME1METTL27RTN3GPSM3FNDC11PTRH1EIF6RRAGDSRGAP3C19orf53NUDT19YRDCSHMT2NOCTPDIA4BRIP1ZNHIT1RUVBL1SPAG5GEMIN7AP1S1POP7DNAAF2LRRC8BDCLRE1BEBPRELBATP2C2TMC7CEBPGCCDC177CD6CCT5NDUFA9CYCSAGPAT2ENO3SNRPCDNPH1HELZ2LRRC43KIF22NDUFA4L2ZSCAN16SLC25A33SIGLEC5SAMD1SAC3D1DCAF13BDH1RAD54BHAUS8TRMT12SLC22A18ASC5orf30YARS2C1orf74HSPE1ADGRE2VRK1PAK4PFDN4FKBPLUQCC3EEF1E1SLC2A6VIPR1ACTR3CDDX39AOCA2FARSACAPN1RPP40IL23ATMEM38AERI3B4GALT5ZFATCDK16EDN1NUDT1RFC4TUBG1ACTL6APAQR5NUDT15SRPK1RGS16C1orf127ZNF365KLK12TCF19PAK1IP1PRIMA1RFXANKSNX32GADD45GIP1TFPTIPO4ADAM8TOMM40HEY2LRIG1ZDHHC9ZDHHC20HAPLN3NIPSNAP1DNA2AP1S2KRASZNF440CLCF1TRIAP1YDJCMRPS30ZDHHC23ARPC5LBRIX1WDR77CENPIFAM189BMROH1TMEM267HM13NDUFAF4HPRT1GGCTIER5LMAPK13RITA1GMPSIQCDMAGOHBPGPLPAR2MRPL52MRPS16MRPL36GSTP1RRP36TBC1D24ERGIC2GFOD1VPS37DTIMM50RUVBL2CNNM4TTYH3RFC2MTX2ITGAXZNF239TOMM34ANAPC15IL1RL2COMMD7RAVER1POLE2DHRS11MLF2TMEM54EFCAB11PRCCATAD2ADASUV39H1MRPS34NEU1MDKTNFRSF4ZNF92TPM4MCM6THAP10RAD23AZNF787MRPL33ACOT7KLRG1FAM32ATDP1CLPTM1LNR2C2APBABAM1ALAS1ADRA2CGMNNDHRS13FANCD2PAIP1C19orf54INTS5RPP38STMN1MXD3TOPBP1MYO6ABT1SLC25A39YES1PPM1GPUS7BORAKLHDC9ESRRAPPP1R16AKEAP1TMEM63CGLDNLYPLA2SMARCC1EHD3SPDL1UBE2V2GATAD2AATP23SLCO5A1POLR2DARHGEF2APEX2CCT3WDR3TARBP2RHEBL1B3GALT6ATG101CHAF1AZNF593TLNRD1SLC7A5NOL10S100A3CDC7REEP4
DOWN
TXNIPRWDD4MACF1COBLL1PDZD2HMBOX1GKAP1EMP3PLXNA4IKBKBNFAT5ZBED5MBD1PIGHSEC63KCTD9MXI1RBL2FAM160B1THUMPD2ZNF655STOMRIC1ZNF81EID3KIF16BFAM160A2DDX3XDYNC1LI2RPL3TBC1D8BZKSCAN7TMEM176BRHOBTB1RCBTB2TCEAL9ZNF711PRKAB2STAT6TMEM43ZCCHC14TBRG1SFRP4USPL1KIDINS220ZNF641ENTPD4NCBP3ZCCHC12MST1DDHD2CCNT2MAP3K3NPDC1PCDH9FAM126AZBTB4UBE2G2CDK20TXLNGPI4KAHNRNPH3GGNBP2PCDH18TMEM50BPRRX1ZC3H6CASD1TLE2MARVELD1KIFC3PHLPP2SNAI2DOCK1TNFRSF10BCCDC84COG3POGZPRPF3GNA11PLSCR4GNG2AHNAKMADDEIF3LERCC6L2TEP1OPHN1KIAA1958CREBRFANTXR1GSE1RNF146UHRF2ZNF407MAMDC4RASA1RAB30NMNAT3ERCC5AKAP9DDX5RNF128ENOSF1ZCCHC11MTMR10FOXP1GNA12LYSMD4ZNF532NMRK1MTFR1LSCD5ZC3H12CSLC26A11THOC1B4GAT1LATS2RPS6KA2MORC3CENPVCWC25THBDFRYSETD7ARRDC3SLC26A6METTL7AZNF234ST13ZNF266FERMT2CBX6FLNCLATCOLGALT2AGAP4GATAD1GNAZSERGEFHECAVPS13BHNRNPA1KATNAL1MLXIPSLKMSANTD2BBS7CDIP1AKAP13LIMA1JOSD1BTN2A1NXF1ZNF493RIPOR1CYP4V2PPWD1ANKRA2ARHGAP19ASB1ABRSLC7A8DOCK4PIM1MON2SCN1BIL6STZRSR2MORC4RAB31STK11TRIM4PCDHB16CPB1PDLIM3ATP9BCTSFSLFN11ATG2BADPRMEXOC6BZNF559ZNF70CYBRD1ZFYVE16MZF1CPNE8ZNF275OCRLKLHL36TNRC6AAP1G2UBXN6MAP3K4NEK3PDE8AZBTB40PLBD2FRMD6ATP6V0A1H6PDKAT2BHSPB8COLCA2ZZEF1CLDN15DENND4AMAP4K5CGNL1CLCN5ARHGEF7MTMR3TMEM98KIZSMC5SNX33PDGFRLADCY9RORBTRIM23HSPA12ACDADC1MTX3PALMNEFHNEK1PLS3DCUN1D4FYCO1HNMTHCFC2UFSP2AHI1GGT5DDHD1CHST15CEP120CIDEBPOLDIP3ADAMTS3SETDB2C5orf56RAB8BDOCK5RBPMS2ZSWIM8NACC2FGFR1OP2PIK3R1BCO2HSPB3GBGT1TTC8GNECRACR2AEPB41L2MLLT6CCDC93XPCEPHX2DGKHC1RLDIRAS1MDN1RALGAPA1OLFML3SHPRHPCNX1LSAMPMPHOSPH8EHD2TK2HERC1MYSM1MTHFRMGEA5RBFOX2DIP2CFAM13AABCD4EID2BSPARTSMG6WDR59ZNF224MTURNLONRF1EVC2TPM1C20orf194NDEL1PCGF3MMP16ERO1BCORO2BEOGTLIFRING2KLHL13DOPEY1MRC2DOK6THRADENND3ABLIM1BRD1SLC22A17CCNL1TMEM8BATP8B4PALLDZEB1G0S2SLC9A9MEF2CCLIC2FNBP4TARSL2PCED1BRXRAIGIPTSPAN4TNS1RNASELERMARDICA1LTSC1DEF8HYICLMPYTHDC2CITED2ETS2P2RX7STMN3N4BP2L2BMP2PAQR7ADRA2ADNAJC12ZBTB20POLIHTRA1MTERF2ANGPTL2ZNF594TACC1TGFB1I1ST3GAL5DMTF1CALD1LIX1LDTX3PRKAR2BTTBK2CAV1MICAMTERF4ABTB1CYP27A1NICN1C5PMM1SSC5DUSTSH3PXD2AOGTID3JAK2GULP1PRKD1DCHS1KCNJ8GCNT7MICAL1ARHGAP21TMEM91OTUD3DMDDSCAML1C11orf95RHOBTB2FHL1SCARB1SLC16A4PAXBP1CLEC2BTOM1L2PMP22LRCH2SYCP2LPRICKLE2PTGISCLIP4CPQBICC1EPB41L3ARHGEF6NEK9METAP1DSMARCA2ANXA6FBN1ACCSRUNDC3BGARNL3SPAG9NAP1L5CREBZFLYRM9TEFIRS1CAB39LARMCX1TPM2ABLIM3SLC16A7RBP1CAVIN1NR3C2GLULSTX2SECISBP2LRP1CAPRIN2AKR1C2INTUARHGEF26ZHX3INTS6LFEZ1FAM13CMITFWNT2BNAP1L3SH3BP5TMOD2EPS8PRKG1PAN2AMIGO2MAPKBP1CDH11SUN2HEPHZCCHC24ARNTLOLFML1CTNNAL1KIAA1109PKD2SOBPC8orf88C9orf72NDNMTUS1CRY2WHRNABCG2PTPN13SNAP91SLC23A2CHST3RIC3SNCASMPD3NINLBTAF1GFRA1GABBR1VIMAGAP9GALNT10ASH2LC3orf70ATP8B2P2RY1TNNI3KPAPSS2PHF1VGLL3HOXC6SERP2KLHDC8BPLCL2SLC26A4TCEAL3TMEM200ATROSLC25A37MAFLHFPL6DYNC1I1DAPK1RAPGEF4CLK1TRABD2ARBM6FGF2TIMP2EDNRATFPIST3GAL4SESN1WFS1TAF1CNFIL3RGNCASP9KLHDC1KANK2PEX5LMYOM2ABCA5WSB1MICU3DCLK1LYVE1SMAD9SULF2TTYH2AKAP17AFAT4ZEB2OMDRUFY3TBC1D2BNUDT11FAM198BRGS2EZH1SOCS2MRVI1RBPMSC1SAKR1C1RBMS3COX7A1PDZRN3PBX3GSTM3NBL1TSC22D3ENOX1EMILIN1NPHP3TWIST2CFHGATMAKAP12TNS2ADHFE1CNRIP1DCNKLF4PPP1R12BGFPT2PARM1RPRMSMOC2DSTPDE2ACOL14A1VLDLRCPEB1PLA2R1PON3PRSS35JAM3PSD3B3GALT2CBX7TCEAL4ANTXR2ADGRB3MRGPRFTBC1D4LIN7AKLF9CAPN3CAVIN2RHOBTB3ATP8A1LRRC17ARHGAP10TGFBR3BAHCC1WNK4ZDBF2SLC7A2ADH1CCSGALNACT1PHACTR3BMPERITPR1KCNT2IGFBP4HS6ST2CLDN11MTUS2PDE7BKLF2TSHZ3MAOAOGNSNCAIPPID1PABPC5ZMAT1YPEL4TBX3ZNF331UBE2Q2LANKRD29ROBO3SLC25A27MAP3K5GPAT3GOLGA8NRAB9BDPTTCF21PEAR1ADGRD1F3DESCOL16A1MCCRASL11BPDK4ADAM33SYNE1PDGFRAAMHR2PODNNDNFSTARD9ZNF385BSLC4A3C21orf62CXorf57ADH1BKLHDC8AHAS1MAMDC2INHANRKCMYA5TDRD10PLA2G2AC7HLFSIGLEC11PEG3ABCA6ABCA8GSTM5MUM1L1SCN7ASTARC4BPBWFIKKN2
DEL
UP
LINC01297LINC01224PART1LINC01667LINC00284OVAALLINC00592LINC00858LINC01215LINC01532LINC01607LINC00221LINC00668LINC00052LINC00536HAGLRLINC01136LINC00867LINC00665LINC01558DLEU1 SAMMSON LINC00996PCAT6LINC00240
DOWN
FTXLINC00622MGC16275C5orf56LINC00173GAS1RRLINC00887 LINC00893
DEM
UP
hsa-let-7b-5phsa-miR-16-5phsa-miR-23a-3phsa-let-7f-5phsa-miR-24-3phsa-miR-27a-3phsa-miR-29c-3phsa-let-7g-5phsa-let-7i-5phsa-miR-130a-3phsa-miR-27b-3phsa-miR-15b-5phsa-miR-106b-5phsa-miR-26b-5phsa-miR-20ahsa-miR-23b-3phsa-miR-148a-3phsa-miR-15a-5phsa-miR-200c-3phsa-miR-10b-5phsa-miR-25-3phsa-miR-34a-5phsa-miR-30d-5phsa-miR-223-3phsa-miR-1225-5phsa-miR-342-3phsa-miR-93-5phsa-miR-494-3phsa-miR-30c-5phsa-miR-331-3phsa-miR-100-5phsa-miR-320a-3phsa-miR-324-3phsa-miR-20b-5phsa-miR-497-5phsa-miR-193a-3phsa-miR-199a-5phsa-miR-374ahsa-miR-125b-5phsa-miR-221-3phsa-miR-98-5phsa-miR-574-3phsa-miR-126-3phsa-miR-376chsa-miR-188-5phsa-miR-148b-3phsa-miR-136-5phsa-miR-660-5phsa-miR-886-3phsa-miR-155-5phsa-miR-424-5phsa-miR-222-3phsa-miR-381-3phsa-miR-150-5phsa-miR-127-3phsa-miR-132-3phsa-miR-542-3phsa-miR-340-3phsa-miR-340-5phsa-miR-532-5phsa-miR-486-5phsa-miR-202-3phsa-miR-874-3phsa-miR-532-3phsa-miR-362-5phsa-miR-654-3phsa-miR-769-5phsa-miR-505-3phsa-miR-487b-3phsa-miR-557hsa-miR-409-3phsa-miR-212-3phsa-miR-337-5phsa-miR-1228-3phsa-miR-194-5phsa-miR-423-5p
DOWN
hsa-miR-324-5phsa-miR-551b-5phsa-miR-194-3phsa-miR-150-3phsa-miR-106a-3phsa-miR-24-2-5phsa-miR-18ahsa-miR-20b-3phsa-miR-449b-5phsa-miR-661hsa-miR-200a-5phsa-miR-558hsa-miR-132-5phsa-miR-338-5phsa-miR-374a-3phsa-miR-193a-5phsa-miR-185-3phsa-miR-769-3phsa-miR-367-3phsa-miR-15b-3phsa-miR-136-3phsa-miR-214-5phsa-miR-127-5phsa-miR-222-5phsa-miR-886-5phsa-miR-223-5phsa-miR-10b-3phsa-miR-331-5phsa-miR-576-3phsa-miR-25-5phsa-miR-376a-5phsa-miR-16-1-3phsa-miR-200b-5phsa-miR-802hsa-miR-148a-5phsa-miR-342-5phsa-miR-106b-3phsa-miR-34a-3phsa-let-7g-3phsa-miR-101-5phsa-miR-29b-1-5phsa-miR-195-3phsa-let-7f-1-3phsa-miR-92a-1-5phsa-miR-23a-5phsa-miR-200c-5phsa-miR-497-3phsa-miR-27a-5phsa-miR-130a-5phsa-miR-424-3phsa-miR-23b-5phsa-miR-30d-3phsa-miR-27b-5phsa-miR-100-3phsa-miR-145-3phsa-miR-141-5phsa-miR-125b-1-3phsa-let-7b-3p
Table S8 KEGG pathways for genes in ceRNA network
ID
Description
P value
Gene
Count
hsa04660
T cell receptor signaling pathway
0.017549
PAK4/VAV3
2
hsa05206
MicroRNAs in cancer
0.021294
E2F3/PAK4/ZEB1
3
hsa04140
Autophagy - animal
0.027357
RRAGD/STK11
2
hsa04068
FoxO signaling pathway
0.028963
SETD7/STK11
2
hsa04150
mTOR signaling pathway
0.037997
RRAGD/STK11
2
2