cytokines

Cytokines Montreal 2008 1

7th Joint Conference of the International Cytokine Society and the International Society for Interferon and Cytokine Research

P R O G R A M

Translating Science into Health: Cytokines in Cancer, Infl ammation and Infectious Diseases

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CytokinesMONTRÉAL 2008

October 12-16, 2008 Fairmont Queen Elizabeth Hotel Montreal Quebec CANADA

2 Cytokines Montreal 2008

From cell separation to molecular analysis

The Gold Standard in Cell Isolation• Separation of functional, cytokine-secreting cells• Virtually any cell type from any species• Superior viability, purity and recovery

Cytokines and Growth Factors• New, broad portfolio: human - mouse - rat• Excellent purity and activity• Optimized for cell culture applications

MACSmolecular Tools for Molecular Analysis• Tools for signal transduction• State of the art microRNA analysis• Comprehensive gene expression profiling

Unless otherwise specifically indicated, Miltenyi Biotec products and services are for research use only and not for therapeutic or diagnostic use.

Miltenyi Biotec Inc.12740 Earhart AvenueAuburn CA 95602, USA

Phone 800 FOR MACS+1 530 888 8871Fax +1 530 888 8925

[email protected]


ContentsWelcome to Montreal ..................................................................................... 4-5

Sponsors and Exhibitors ................................................................................... 6

Conference Venue ............................................................................................ 11

Scientifi c Information ...................................................................................... 12

Registration ...................................................................................................... 14

Program at a Glance ........................................................................................ 15

Conference Floor Plan ..................................................................................... 16

Invited Speakers .............................................................................................. 16

Scientifi c Program

Sunday, October 12 ............................................................................... 17

Monday, October 13 .............................................................................. 18

Tuesday, October 14 .............................................................................. 28

Wednesday, October 15 ........................................................................ 36

Thursday, October 16 ............................................................................ 45

General Information ........................................................................................ 47

Social Program ................................................................................................ 48

A Walking Tour of Downtown ......................................................................... 50

John Hiscott, McGill UniversityMarc Servant, Université de MontréalEleanor Fish, University of Toronto

Christine Czarniecki (USA)Thomas Decker (Austria)Scott K. Durum (USA)Takashi Fujita (Japan)Adolfo Garcia-Sastre (USA)Otto Haller (Germany)Raymond Kaempfer (Israel)George Kukolj (Canada)Santo Landolfo (Italy)Allan Lau (China)Warren Leonard (USA)

Alberto Mantovani (Italy)Eliane Meurs (France)Luke A.J. O’Neill (Ireland)Nancy Reich (USA)Christian Schindler (USA)Josef Schwarzmeier (Italy)Michael Tovey (France)Carl Ware (USA)Bryan Williams (Australia)Howard Young (USA)

Karen Mossman, McMaster UniversityMichele Barry, University of AlbertaJohn Schrader, University of British Columbia

Canadian Organizing Committee

International Organizing Committee


Bienvenue à MontréalC’est avec grand plaisir que je vous souhaite la bienvenue à cette 7e

rencontre conjointe de la Société internationale pour la recherche sur

l’interféron et les cytokines et de la Société internationale des cytokines :

Cytokines 2008. Notre conférence a mobilisé l’expertise biomédicale

et les efforts de ces deux sociétés afi n de vous présenter une mise à jour

complète des hypothèses les plus récentes quant au rôle élémentaire et clinique

des cytokines dans le cancer, l’infl ammation et les maladies infectieuses. Le

thème général de cette conférence, l’utilisation des connaissances scientifi ques

pour améliorer la santé, a été choisi afi n de mettre l’emphase sur l’intégration

des recherches fondamentales, précliniques, pharmaceutiques et cliniques

dans les domaines du cancer, de la modulation immunitaire, de l’infl ammation

et des maladies infectieuses. Les sujets abordés comprendront l’identifi cation

des pathogènes et leur signalisation pour le déclenchement d’une réaction

immunitaire, l’infl ammation et le cancer, la biologie et les fonctions des cellules

immunitaires et des cytokines, et les stratégies utilisées par les pathogènes

pour échapper à la réaction immunitaire de l’hôte. Une part importante de

la conférence sera aussi dédiée aux traitements agissant sur les cytokines

dans le cancer et d’autres troubles de santé, ainsi que sur les thérapies

émergentes ayant pour cible les cytokines dans les maladies autoimmunes

et infl ammatoires. Des scientifi ques chevronnés, des jeunes chercheurs, des

médecins, des boursiers postdoctoraux, des étudiants aux cycles supérieurs

et des représentants des compagnies pharmaceutiques profi teront amplement

de ce lieu de réunion favorisant les échanges. Nous croyons que cette

conférence—qui a lieu dans la belle ville cosmopolite de Montréal lors de

l’époustoufl ante fête des couleurs de l’automne—mettra en évidence les

meilleures recherches actuelles sur les cytokines.

4


Welcome to MontrealIt is my pleasure to welcome you to the 7th Joint Meeting of the

International Society for Interferon and Cytokine Research and the

International Cytokine Society: Cytokines 2008. Our Conference

has harnessed the biomedical expertise and energies of both societies

to provide a comprehensive update of recent insights into basic and

clinical aspects of Cytokines in Cancer, Infl ammation and Infectious

Diseases. The overall theme of this Conference is Translating Science into

Health, and is chosen to emphasize the integration of basic, pre-clinical,

pharmaceutical and clinical research in the areas of cancer, immune

modulation, infl ammation and infectious diseases. Topics to be covered

include: pathogen recognition and signaling to the immune response,

infl ammation and cancer, the biology and functions of immune cells and

cytokines, and pathogen strategies to evade the host immune response.

Part of the conference is also devoted to cytokine-based therapies in

malignancy and other disorders, as well as emerging therapies targeting

cytokines in autoimmune and infl ammatory diseases. Senior scientists,

young investigators, physicians, postdoctoral fellows, graduate students

and representatives of the pharmaceutical industry will all benefi t from

the interactions available at this venue. We believe that this Conference—

set in the beautiful cosmopolitan city of Montreal during the stunning fall

display of colors—will refl ect the best of current cytokine research.

5


Platinum

Silver

Bronze

T H A N K Y O U T O

Gold


O U R S P O N S O R SSponsors

Supporter

Other Amounts


Exhibitors

Assay Designs, Inc.Emily Riesterer Marketing Communications Supervisor 5777 Hines Dr.Ann Arbor, MI 48108Tel: 800-833-8651 or 734-668-6113Fax: 734-668-2793Website: www.assaydesigns.com

BOOTH #1Representative: Tonya Goodman

Assay Designs manufactures immunassays, antibodies, and proteins for the academic and pharmaceutical research markets, including custom immunoassay development and custom bulk reagent production and conjugation.

BD BiosciencesAndrea Brueschke, Product Manager2280 Argentia RoadMississauga, ON L5N 6H8Tel: 905-542-6285Fax: 905-542-9391Website: http://www.bdbiosciences.com/

BOOTH #12Representatives: Alex Brunet, Benoit Lachapelle

BD Biosciences (Becton, Dickinson and Company) is a medical technology company that serves healthcare institutions, clinical laboratories, life science researchers, and industry. BD manu-factures and sells a broad range of medical supplies, devices, laboratory equipment and diagnostic products. BD Biosciences, a segment of BD, provides a comprehensive portfolio of con-sumables, reagents, and instruments, including antibodies, tissue culture products, and fl ow cytometers, to support the life sciences industry.

Bender MedSystems GmbHMs Birgit Osterhoff, Ph.D.International Distributor Coach Campus Vienna Biocenter 2Vienna, Austria 1030Tel: +43-01-796-4040-111Fax: +43-01-796-4040-400Website: http://www.bendermedsystems.com/

BOOTH #5Representatives: Ms Birgit Osterhoff, Ph.D.

Our portfolio includes Elisa Kits, Antibodies and Proteins for re-search in immunology and cellular biology, adhesion, cytokines, apoptosis, tumor biology.

Bender MedSystems FlowCytomix bead-based assays follow the same principle as a sandwich immunoassay. The FlowCytomix multiplexing technology enables the simultaneous detection of multiple analytes from only 25 µl of sample! FlowCytomix kits can be used on most commercially available fl ow cytometers. Chemokines are inter-cellular messengers in infl ammatory reac-tions and immunity, but also play a role in many pathological processes.

BioLegend, Inc.Claudia Arellano, Marketing Coordinator11080 Roselle StreetSan Diego, CA 92121Tel: 858-455-9588Fax: 858-455-9587Website: http://www.biolegend.com/

BOOTH #3Representatives: Gene (Jeng Guang) Lay, Benjamin (Brad) Kraft, Shaoquan Ji

BioLegend, Inc. manufactures reagents for immunology and cell biology research. Selection of fl uorochrome conjugated antibodies, including Pacifi c Blue, Alexa and tandem dyes. Novel antibodies: Treg (FOXP3, TSLP-R, GITR). Innate Immunity (TLRs, NTB-A, CCR7), Cytokines.Chemokines (IL-17, 1L-23,TSLP), Stem Cells (Nanog, FZD9, SOX-2, REX-1, FOXD3, FOXO3a); for FACS, ELISA, ELISPOT, IHC, IP, IF and WB.

Cedarlane Laboratories Ltd.Naomi Wessel-Bonnar, Marketing Coordinator4410 Paletta CourtBurlington, ON L7L 5R2Tel: 289-288-0001, Toll Free: 1-800-268-5058Fax: 289-288-0020, Toll Free: 1-800-638-5099Website: http://www.cedarlanelabs.com/

BOOTH #9 & 10Representatives: Kyle Pahapill and Kevin Tutenberg

Cederlane specializes in providing high quality reagents to the life science community. We are an ISO 9001: 2000 and ISO 13485:2003 registered company. Acting as both a manufacturer and a distributor we offer monoclonal & polyclonal antibod-ies, molecular and cell biology reagents, micro-arrays, custom services, temperature sensitive shipping supplies & more.

eBioscienceRachel Yeager, Marketing Communications Specialist10255 Science Center Dr.San Diego, CA 92121Tel: 888-999-1371Fax: 858-642-2080Website: http://www.eBioscience.com/

BOOTH #11Representatives: Edwin Chau, Peggy Just, David Sehy, Mark Konrad

eBioscience provides innovative high quality reagents to researchers worldwide that empower the process of scientifi c discovery in the areas of cellular immunity and oncology. Our extensive portfolio of leading edge cell analysis products and technologies focused on fl ow cytometry and immunodetection position our customers to be at the forefront of science.

GSK – GlaxoSmithKline Biologicals North AmericaDaniel Larocque, Ph.D., Scientist525 Blvd. Cartier WestLaval, Quebec H7V 3S8Tel: 450-978-8293Fax: 450-978-6343Website: http://www.gsk-bio.com/

BOOTH #13Representative: Daniel Larocque, Steven Tran


HumanZyme Inc.Frederic Rhoads, Vice-President Sales and Marketing2201 W. Campbell Pk. Dr. 24Chicago, IL 60612Tel: 312-738-0127Fax: 312-276-8128Website: http://www.humanzyme.com/

BOOTH #21Representative: Frederic Rhoads

Human cell expressed cytokines and growth factors, non-human cytokines, human kinases, coagulation proteins.

InvitrogenDana Bassett, Marketing Project Coordinator5791 Van Allen WayCarlsbad, CA 92008Tel: 541-335-0346Fax: 541-344-6504Website: http://www.invitrogen.com/

BOOTH #14Representatives: Jeff Croissant, Thao Sebata, Stephanie Graber

Invitrogen Corporation provides products and services that support academic and government research institutions and pharmaceutical and biotech companies worldwide in their ef-forts to improve the human condition. Invitrogen is your source for Molecular Probes, BioSource, Caltag, and Zymed cellular pathway exploration tools, including ELISAs, Luminex® assays, kinase activity assays, protein arrays, antibodies and recom-binant proteins. Our products help researchers improve their understanding of the role of both extracellular proteins and intracellular proteins and their function in the disease process. Invitrogen is committed to providing the most innovative path-way solutions along with personalized customer support.

Mabtech ABAlexandre Antoni, International Sales ManagerAugustendalsvägen 19Nacka Strand, Sweden 131 28Tel: 46(0)8-556 798 23, 46(0)8-716 27 00Fax: 46(0)8-716 27 01Website: http://www.mabtech.com/

BOOTH #2Representatives: Alexandre Antoni, Sten Braesch-Anderson

Mabtech AB is a privately owned Swedish biotech company founded in 1986. Emerging from the Department of Immunol-ogy at Stockholm University, Mabtech has become a world leader in ELISpot and T-cell measurements.

Medicorp Inc.Normand PepinGeneral Manager5800 RoyalmountMontreal, Qc H4P 1K5Tel: 514-733-1900, Toll free:1-877-733-1900Fax: 514-733-1212Website: http://www.medicorp.com

BOOTH #20Representatives: Louise Blanchette, Genèvieve Bourque

MEDICORP is one of Canada’s largest, independent distributors of immunodiagnostic and research products. MEDICORP distributes an expanding line of products in immunology, endocrinology, cell biology, molecular biology and labware products.

Meso Scale Discovery, A Division of Meso Scale Diagnostics, LLC.Debbie O’Connell, Marketing Specialist/Event Planner9238 Gaither RoadGaithersburg, Maryland 20877 Tel: 240-831-2522Fax: 240-632-2219Website: http://www.mesoscale.com/

BOOTH #18Representatives: Carter Cliff, Brooke Murphy

Meso Scale Discovery (MSD®) specializes in detection of proteins in biological samples. Through the combination of patterned arrays and electrochemiluminescence, the MSD platform increases throughput via multiplex capability, offers sensitive assays with wide dynamic ranges.

Millipore CorporationNatasha Sotomayor, Exhibit Specialist290 Concord RoadBillerica, MA 01821Tel: 800-645-5476Fax: 800-645-5439Website: http://www.millipore.com/

BOOTH #17Representatives: Janna Pull, Todd Hendrich

Millipore offers the largest portfolio of biomarker immunoassays including RIAs, ELISAs, Multiplex Assays using the Luminex xMAP technology (MILLIPLEXTM) for the better understanding of the mechanisms of diseases such as diabetes, obesity, cancer, cardio-vascular disease, infl ammation and more, providing consistent, high-quality products for drug discovery and development. The expertise of Upstate Chemicon and Linco are now a part of Millipore.

Miltenyi Biotec, Inc.Kent Jordan ([email protected])Product Marketing Specialist12740 Earhart AvenueAuburn, CA 95602Tel: 530-887-5321 (direct)Fax: 1-800-367-6227 (toll free)Website: http://www.miltenyibiotec.com/

BOOTH #24Representative: Kirt Braun

MACS® Column Technology – The gold standard in magnetic cell separationMACS Technology is based on MACS MicroBeads, MACS Columns and Separators. Gentle and fast separation of cells labeled with mini-mal amounts of MACS MicroBeads. Column technology allows for convenient sample processing and washing under sterile conditions. Excellent purity and recovery of viable and functionally active cells. Please visit our web site www.miltenyibiotec.com to fi nd out more about more than 250 MACS Cell Separation Reagents.MACS® Column Technology – For manual and automated magnetic cell separation.

PBL Interferon SourceJaleel Shujath131 Ethel Road W, Suite #6Piscataway, NJ 08854Tel: 732-777-9123Fax: 732-777-9141Website: http://www.interferonsource.com/

BOOTH #7Representative: Jaleel Shujath

World’s leading manufacturer and distributor of interferon products.

Exhibitors


PeproTech, Inc.Dawn Huxley, Sales ManagerP.O. Box 275, 5 Crescent AvenueRocky Hill, NJ 08553Tel: 609-497-0253 x123Fax: 609-497-0321Website: http://www.peprotech.com/

BOOTH #19Representatives: Jason Palmucci, McDuffy Barrow

PeproTech manufactures an extensive line of Recombinant Human, Murine and Rat Cytokines as well as a complementary line of Mono-clonal Antibodies, Affi nity Purifi ed Polyclonal Antibodies, Affi nity Pu-rifi ed Biotinylated Polyclonal Antibodies and Elisa Development Kits.

Pfi zer Canada Inc.Nathalie Savoie, Administrative Coordinator, Medical division17300 Trans Canada HighwayKirkland, Quebec H9J 2M5Tel: 514-426-7544Fax: 514-693-4500Website: http://www.pfi zer.ca

BOOTH #8Representatives: Sophia Calmels, Guillaume Feugere, Karima Fazal-Karim, Luc Levesque, Christine Mormont, Bertrand Roy

Pfi zer Canada Inc. is the Canadian operation of Pfi zer Inc, the world’s leading pharmaceutical company and is located in Kirkland, Quebec. Pfi zer discovers, develops, manufactures and markets prescription medicines for humans and animals. Pfi zer Inc invests more than US$7 billion annually in R&D to discover and develop innovative life-saving and life-enhancing medicines in a wide range of therapeutic areas. Global headquarters are located in New York City, where the company was founded in 1849.

R&D SystemsTracey Husted, Marketing614 McKinley Place NEMinneapolis, MN 55413Tel: 612-379-2956Fax: 612-379-6580Website: http://www.rndsystems.com/

BOOTH #4Representative: Vassilios Kalabokis

R&D Systems serves the basic research, clinical research, and diag-nostic markets with products for cell biological research. We provide purifi ed proteins; antibodies; kits and reagents for ELISAs, multiplex assays and assays services.

Randox Laboratories, [email protected] Diamond RoadCrumlinCo. AntrimUnited Kingdom BT29 4QYTel: +44 (0) 28-9442-2413Fax: +44 (0) 28-9445-2912Website: http://www.randox.com/

BOOTH #6Representatives: Craig Matson, Jonathon Porter

Randox is an international diagnostics company, headquartered in the UK, which develops, manufactures and markets clinical diag-nostics worldwide. Randox specialise in biochip arrays and Biochip Array Technology analysers. The range of biochip arrays includes cytokine biochips for simultaneous detection of up to 12 cytokines in a single sample.

RocheHélène Ouellett, Marketing Coordinator, Freezer ProgramApplied Science & Molecular DiagnosticsLaboratory, Hospital and Research Systems201 Boul Armand-FrappierLaval, QC H7V 4A2 CanadaTel: 450-686-5486Fax: 450-686-7009Website: http://www.roche-applied-science.com

BOOTH #23Representatives: Julies Desnoyers, Julie Fortier

Rules Based Medicine, Inc.Rob Bencher, Director3300 Duval RoadAustin, TX 78759Tel: 215-806-1747Fax: 215-733-9225Website: http://www.rulesbasedmedicine.com/

BOOTH #22Representative: Rob Bencher

Rules Based Medicine is a service laboratory which provides multi-analyte profi le (MAP) testing. MAPS provide a comprehensive evaluation of protein response to disease, drugs, or the enviro-nment. All studies are performed under GLP guidelines and are typically performed within a period of 2 weeks. Please contact [email protected] for additional information.

STEMCELL Technologies Inc.Julie Robinson, Conference Coordinator400-570 West 7th Ave.Vancouver, B.C. V5Z 1B3Tel: 604-675-7715Fax: 1-800-567-2899Website: http:// www.stemcell.com

BOOTH #16Representatives: Benoit Guilbault, Paul Wolf

About STEMCELL Technologies – STEMCELL Technologies, a leader in specialty cell culture media, cell separation products and ancillary reagents for life science research, is a privately-owned biotechnol-ogy company based in Vancouver, Canada. Driven by science, STEMCELL delivers over 800 products to more than 60 countries worldwide. To learn more about how STEMCELL helps to make research work, visit

Wisent, Inc.Michel Rotaru, Sales RepresentativeP.O. Box 131, St-BrunoMontréal, Québec J3V 4P8Tel: 450-446-2660Fax: 450-446-7038Website: http://www.wisent.ca/

BOOTH #15Representative: Michel Rotaru

Exhibitors


Conference Venue

Important Addresses & Information

CONFERENCE SECRETARIAT

Gabriella Di PancrazioLady Davis Institute for Medical ResearchSir Mortimer B. Davis – Jewish General Hospital3755 chemin de la Côte Ste-CatherineMontréal, Québec H3T 1E2Tel: 514-340-8308 Fax: 514-340-7502 E-mail: [email protected]

SCIENTIFIC SECRETARIAT

Prof. Dr. John HiscottLady Davis Institute for Medical Research Sir Mortimer B. Davis – Jewish General HospitalMcGill University3755 chemin de la Côte Ste-CatherineMontréal, Québec H3T 1E2E-mail: [email protected]

EXHIBITION MANAGEMENT

Clarkson Conway – Exhibits AVW-TELAV – AudiovisualChristine Lalonde – Graphic DesignMélanie Philion – Hotel Liason

CONGRESS HOME PAGE

http://www.cytokines2008.org

Cytokines 2008 is being held at the Fairmont Queen

Elizabeth Hotel, centrally located adjacent to Place Ville Marie in the downtown area of Montreal.

Fairmont Queen Elizabeth Hotel

900, René Lévesque OuestMontréal, Québe H3B 4A5Tel: 514-861-3511 Fax: 514-954-2256

http://www.fairmont.com

For other useful information about Montreal, please visit: www.tourisme-montreal.org

Airport:

Pierre Elliott Trudeau International, 22 km west of downtown, now serves all domestic, U.S. and inter-national passenger fl ights.

A taxi ride from anywhere in town to Trudeau Airport costs a fl at rate of $38-$40 CDN.

Aerobus shuttle bus service runs from the downtown bus terminal (514-842-2281) with several stops before taking the highway. Fares are lower than taxis: $12-$15 CDN to or from Trudeau airport.

It is also possible to get to Trudeau Airport by taking regular city buses: the 211 and the 204 will get you there from downtown, but the 211 could be tricky with a lot of baggage at busy times of day.

Buses:

Montreal has bus connections to other cities within Quebec, to the rest of Canada and to the United States. Intercity bus travel does not carry the same stigma as in the U.S. and the buses to Quebec City and Toronto, for example, are clean and pleasant. The main bus terminus is the Station Centrale at the corner of Berri and de Maisonneuve, tel. 514-842-2281.

Trains:

Montreal is on the Via Rail Windsor-Quebec corridor. You can reserve tickets on their website or get them from your travel agent.

Amtrak runs the Adirondack from New York to Montreal daily. Their website also offers reservations.

There are two major downtown train stations, Central Station (Gare Centrale) and Windsor Station (recently renamed L’Allier Station). Both are connected to the Bonaventure Metro station and are thus connected to the underground city. Windsor/L’Allier is only used for commuter trains now.


Scientifi c Information Overview of the Sessions

All Plenary sessions (PL1 – PL4) will take place in the Grand Salon from 8:30 – 12:30 (Mon-Thurs); two parallel Symposia (SY1-SY6) will take place each day (Mon-Wed) from 16:30 – 18:00 and four concurrent Workshops (Mon-Wed) will take place each day from 14:00 – 16:00 (WO1-WO12). Four concurrent Poster sessions (PP1-PP12) will also take place each day from 18:00 – 19:30, with selected Poster Discussions (PD) taking place each evening from 18:15 – 19:30. Also, a Late Breaking (LB) session has been scheduled for Thursday Oct. 16 at 14:00-16:00. The abbreviations above (PL1, SY2, WO3 and PP4 etc) refer to the specifi c sessions; the number following the session designation denotes the Abstract number in the Conference Abstract issue of CYTOKINE.

Presentation Instructions for Workshops and Posters

On the following pages are the titles and authors (including Abstract numbers and session type) for the Plenary, Symposia, Workshop and Poster Sessions. Please note that WO refers to a Special Topics Workshop (also referred to as an Oral Presentation), PP refers to a Poster Presentation, and PD refers to a Poster Discussion Session. The number following the ab-breviation indicates the session number, followed by the Abstract number in the Conference issue of CYTOKINE.

Workshop Sessions:

Listed below are the Workshop Sessions including day and time of presentation, abstract numbers in each session and session chairs. The time allotted for oral presentations is 15 minutes (12 minutes for talk and 3 minutes for discussion). Please be certain to time your presentation to conform to these guidelines. Both PC and Mac computers will be available to load your presentation.

Chairpersons are asked to be in the session room at least 15 minutes prior to the beginning of the session and should make every effort to maintain the time schedule.

Speaker Ready Room:

Saguenay located on the Convention Floor Level of the Fairmont Queen Elizabeth Hotel is the designated “Speaker Ready Room”. It will be open throughout the meeting so that you may prepare or preview your material prior to your oral presentation. It is recommended that you bring your presentation on a USB fl ash drive or CD. The technician in your session room will be available to pre-load your talk onto a central computer (PC and Mac available) to avoid delays between presentations. You will need to be in the session room approximately 30 minutes prior to the session, so that loading of talks can be completed prior to the fi rst presentation.

Poster Sessions:

Posters are divided into three sessions – one session per day (Sessions listed below). Authors are requested to put up their posters during the morning of the specifi c poster session (or the night before, as soon as the boards are ready). The posters will be available for “brows-ing” throughout the day (08:30 – 19:30). Poster Sessions (and Poster Discussion Sessions) with Wine and Cheese will be from Monday – Wednesday between 18:00 – 19:30 each day. Presenters are requested to stand by their posters during this designated poster session time on their scheduled day to answer questions. Poster sessions will be held in Hochelaga 2-6. After the session, please remove your poster by latest 20:00 as posters will be changed every day.

• Posters can be fi xed with push pins provided by the Conference Management which will be available in the Poster Session Rooms and at the Registration Desk. Should you wish to use Male-velcro, you will need to bring your own.

• Please note that only posters 4 feet high (from top to bottom) and 8 feet wide (from side to side) can be presented.


Poster Discussion Sessions:

Each evening during the Poster session, 4 to 6 posters will be highlighted for a short discus-sion session from 18:15 – 19:30. Presenters are invited to prepare a 10 minute slide presenta-tion of the results of their poster. Please leave time for questions. Selected posters will be grouped together in a semi-circle in Hochelaga 2 and delegates are invited to attend this short informative focus session. Please note that because of the large number of posters

in PP2, three topics will be presented on Monday, October 13, fi ve topics will be presented

on Tuesday, October 14, and four topics will be presented on Wednesday, October 15, as

indicated in the table below.

DATE TOPICS

Monday, October 13 PP1: Signal Transduction I

PP2: Cytokines in the Pathogenesis of Infl ammatory Disease

PP3: Cytokines and Chemokines: Mechanisms of Action

Tuesday, October 14 PP4: Immune Cell Activation and Function

PP5: Gene Regulation: Transcriptional and Post-transcriptional Mechanisms

PP6: Control of Cell Growth and Death in Cancer and Hematopoiesis

PP7: Structure and Function of Cytokines and their Receptors

PP8: Pathogen Evasion of the Host Cytokine Response

Wednesday, October 15 PP9: Cytokines in the Development of Innate and Adaptive Immunity

PP10: Induction of Cytokines and Interferons

PP11: Cytokines in Preclinical Models of Cancer and Infectious Disease

PP12: Signal Transduction II

Speaker Ready Room

Will be open during the registration hours.

It is important that all speakers check their presentations before their sessions in the Speaker Ready Room, the Saguenay located on the Convention Floor. This room will be available as of Sunday, October 12, 2008 – 12:00.

If you are scheduled to speak in the morning we ask you to check your presentation the afternoon before.

For afternoon presentation please check at least two hours prior to the beginning of your session.


Registration

The registration fee for participants includes:

• Admission to the scientifi c sessions

• Admission to the commercial exhibition

• Conference documents and the Abstract book

• Opening Ceremony and Welcome Reception at the Fairmont Queen Elizabeth Hotel, Hochelaga 1-6, Sunday, October 12, 2008

• Notre Dame Basilica de Montreal Monday, October 13, 2008 (since space is limited, only the fi rst 320 registrants can be accepted)

• An Evening at the Montreal Museum of Fine Arts Tuesday, October 14, 2008

• Gala Dinner in the heritage Windson StationWednesday, October 15, 2008

The registration fee for accompanying persons includes the following:

• Opening Ceremony and Welcome Reception at the Fairmont Queen Elizabeth Hotel, Hochelaga 1-6, Sunday, October 12, 2008

• Admission to the commercial exhibition

• Notre Dame Basilica de Montreal Monday, October 13, 2008 (since space is limited, only the fi rst 320 registrants can be accepted)

• An Evening at the Montreal Museum of Fine Arts Tuesday, October 14, 2008

• Gala Dinner in the heritage Windson Station Wednesday, October 15, 2008

MEZZANINE LEVEL and ALCOVE LEVEL

The registration desk will be open:

Sunday, October 12, 2008 13:30 – 20:00

Monday, October 13, 2008 through Wednesday, October 15, 2008 08:00 – 18:00

Thursday, October 16, 2008 08:00 – 12:00

Registration Fees Early Advance At The Meeting

Academic/Government (member) $500 $600 $650

Academic/Government (non member) $600 $700 $750

Industry $700 $800 $900

Students/Residents/Postdocs $250 * $300 $350

Accompanying Guests $200 $250 $300

*Early registration for 4 or more students from the same laboratory will receive one complimentary registration.


Program at a Glance

Su

nday

M

onda

y

Tues

day

W

edne

sday

Th

ursd

ay

Tim

e O

ctob

er 1

2, 2

008

O

ctob

er 1

3, 2

008

Oct

ober

14,

200

8 O

ctob

er 1

5, 2

008

Oct

ober

16,

200

8

07

:30

– 08

:30

ISIC

R / I

CS J

oint

Boa

rd

Mee

ting

(Ric

helie

u)

08

:30

– 10

:30

Plen

ary

Sess

ion

1

Plen

ary

Sess

ion

2

Plen

ary

Sess

ion

3

Keyn

ote

Lect

ure

II

Patte

rn R

ecog

nitio

n Re

cept

ors

In

fl am

mat

ion

and

Canc

er

Cyto

kine

s an

d Em

ergi

ng

Dr.

Tada

Tan

iguc

hi

and

Sign

alin

g to

Inna

te

In

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SAINTCHARLES

MAURICESAINT

GATNEAU

SAINTLAURENT

SAGUENAY

LE GRAND SALON MARQUETTE JOLLIET DULUTH MACKENZIE

YAMASKA

MATAPEDIA

Hochelaga1

Hochelaga2

Hochelaga3

Hochelaga4

Hochelaga5

Hochelaga6

CHAUDIERE

HARRICANA

RICHELIEU

PERIBONCA

BERMISE

BAECHER-ALLAN Clare, Harvard University (USA)BARBER Glen, University of Miami (USA)BLATT Lawrence M., Alios BioPharma, South San Francisco (USA)BOWIE Andrew, Trinity College Dublin (Ireland)BROWNING Jeff, Biogen Idec (USA)CHENG Genhong, University of California, Los Angeles (USA)COYLE Anthony, MedImmune Inc. (USA)CROW Mary K., Weill Medical College (USA)DAVID Michael, University of California, San Diego (USA)DONG Chen, MD Anderson, Houston TX (USA)DECKER Thomas, University of Vienna (Austria)DINARELLO Charles, University of Colorado (USA)FELDMANN Heinz, Rocky Mountain Labs (USA)FELDMANN Marc, Kennedy Institute of Rheumatology (UK)FISH Eleanor, University Health Network, University of Toronto (Canada)FOX Paul, Lerner Research Institute, Cleveland Clinic (USA)FUJITA Takashi, Kyoto University (Japan)GAFFEN Sarah, SUNY Buffalo (USA)GALE Michael, University of Washington (USA)GARCIA-SASTRE Adolfo, Mount Sinai School of Medicine (USA)GOODALL Greg, Hanson Institute, Adelaide (Australia)HORVATH Curt, Northwestern University (USA)HSIEH Chyi-Song, Washington University, St. Louis (USA)JOVE Richard, Beckman Research Institute, City of Hope (USA)KISHIMOTO Tadamitsu, Osaka University (Japan)KOLLIAS George, Alexander Fleming Institute (Greece) LAFAILLE Juan, New York University (USA)

LEONARD Warren, National Institutes of Health (USA)LI Xiaoxia, Lerner Research Institute, Cleveland Clinic (USA)LIU Yong-Jun, MD Anderson Houston (USA)MAK Tak, University Health Network, University of Toronto (Canada)MANTOVANI Alberto, Instituto Clinico Humanitas (Italy)McFADDEN Grant, University of Florida (USA)MEDZHITOV Ruslan, Yale University School of Medicine (USA)MIKKOLA Marja, University of Helsinki (Finland)O’NEILL Luke A.J., Trinity College Dublin (Ireland)O’SHEA John, National Institutes of Health (USA)OZATO Keiko, National Institutes of Health (USA)PHILPOTT Dana, University of Toronto (Canada)REIS E SOUSA Caetano, London Research Institute, (UK) SCHINDLER Christian, Columbia University (USA)SEN Ganes C., Lerner Research Institute, Cleveland Clinic (USA)SHEVACH Ethan, National Institutes of Health (USA) SILVERMAN Robert H., Lerner Research Institute, Cleveland Clinic (USA)SONENBERG Nahum, McGill University (Canada)TANIGUCHI Tadatsugu, University of Tokyo (Japan)TING Jenny P-Y., University of North Carolina at Chapel Hill (USA)TRINCHIERI Giorgio, National Cancer Institute-Frederick (USA)TSCHOPP Jurg, University of Lausanne (Switzerland)VAN DEN BERG Wim, University of Nijmegen Medical Center (Netherlands)WARE Carl, LaJolla Institute of Allergy and Immunology (USA)WILLIAMS Bryan, Monash Institute (Australia)YOUNG Howard A., National Cancer Institute-Frederick (USA)

Speakers

Fairmont The Queen Elizabeth Hotel


OPENING SESSION LE GRAND SALON18:00 OPENING REMARKS - WELCOME

John Hiscott (Chair, Scientifi c Organizing Committee) Eleanor Fish (President, International Society for Interferon and Cytokine Research) Carl Ware (President, International Cytokine Society)

ISICR AND ICS AWARDS PRESENTATIONSDrs. Robert Silverman and John Sims

ICS AwardsHonorary Life Membership ICS Young Investigator Award ICS Postdoctoral Investigator Award ICS Outstanding Scholar Award

HONORARY LECTURES19:00 HON-1 Anti TNF and the Beginning of Anti Cytokine Medicine. Marc Feldmann, Head, Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College London, UK. ICS Honorary Life Membership Award

19:30 HON-2 Role of Pro-Infl ammatory Cytokines in Carcinogenesis. Giorgio Trinchieri, Cancer and Infl ammation Program, Center for Cancer Research, National Cancer Institute, Frederick, MD. ISICR Seymour and Vivian Milstein Award

KEYNOTE LECTURE20:00 KEY-1 Translational Control of Innate Immunity via IRF-7. Nahum Sonenberg, Department of Biochemistry and McGill Cancer Centre, McGill University, Montréal, QC.

20:30 WELCOME RECEPTION – HOCHELAGA 1 TO 6

Sunday, October 12, 2008

11:00 – 12:30 ISICR Publications Committee MATAPÉDIA12:00 – 13:30 ISICR Membership Committee CHAUDIÈRE12:30 – 14:30 ICS & ISICR Meetings Committees SAINT MAURICE12:45 – 14:15 ISICR Finance Committee MATAPÉDIA 13:45 – 15:15 ISICR Awards Committee CHAUDIÈRE 15:00 – 16:30 ISICR Nomenclature Committee SAINT MAURICE15:00 – 17:00 ISICR Standards Committee MATAPÉDIA15:30 – 17:30 ISICR Board of Directors CHAUDIÈRE

14:00 – 17:30 ICS Council Meeting HARRICANA

ISICR Awards Seymour and Vivian Milstein Award Honorary MembershipSeymour and Vivian Milstein Young Investigator AwardsSeymour and Vivian Milstein Travel Awards Christina Fleischmann Award to Young Women Investigators


Monday, October 13, 2008

PLENARY SESSION 1 LE GRAND SALON

PATTERN RECOGNITION RECEPTORS AND SIGNALING TO INNATE AND ADAPTIVE IMMUNITY

Chairpersons: Luke A.J. O’Neill, Trinity College Dublin (Ireland) Marc Servant, Université de Montréal (Canada)

08:30 PL1-1 The IL-1 Receptor / Toll-like Receptor Superfamily: 10 Years of Progress. Luke A.J. O’Neill, School of Biochemistry and Immunology, Trinity College Dublin, Ireland.

09:00 PL1-2 Innate Recognition Pathways in Dendritic Cells. Caetano Reis e Sousa, Immunobiology Laboratory, Cancer Research UK, London Research Institute, London, UK.

09:30 PL1-3 Insights into Innate Immune Signaling Pathways from Vaccinia Immune Evasion. Andrew G. Bowie, School of Biochemistry and Immunology, Trinity College Dublin, Ireland.

10:00 PL1-4 Role of Nod-like Receptors in Innate and Adaptive Immunity. Dana Philpott, Department of Immunology, University of Toronto, Toronto, ON.

10:30 COFFEE BREAK – FOYER

11:00 PL1-5 New Functions for NLR Proteins: Cell Death and Type I IFN Response. Jenny P-Y Ting, University of North Carolina at Chapel Hill, USA.

11:30 PL1-6 Danger Signals, Interferons and Autoimmune Disease. Anthony Coyle, MedImmune Inc., Gaithersburg, USA.

12:00 PL1-7 Mechanism of Foreign RNA Recognition in the Cytoplasm. Takashi Fujita, Laboratory of Molecular Genetics, Institute for Virus Research, Kyoto University, Kyoto, Japan.

12:30 LUNCH BREAK – ON YOUR OWN


WORKSHOP 1 LE GRAND SALONSIGNAL TRANSDUCTION I

Chairpersons: Leon Platanias, Northwestern University (USA) Paula Pitha, Johns Hopkins University (USA)

14:00 WO1-5 The Role of IRF-5 in the Antiviral and Infl ammatory Response. Mumtaz Y. Balkhi, Katherine A. Fitzgerald and Paula M. Pitha, Johns Hopkins University School of Medicine, Baltimore, MD. ISICR Honorary Membership Award

14:15 WO1-6 New pathway for IRF-3-activation by RIG-I that causes its mitochondrial translocation and apoptosis. Saurabh Chattopadhyay, Joao T. Marques, Bryan Williams and Ganes C. Sen, Lerner Research Institute, Cleveland Clinic, Cleveland, OH.

14:30 WO1-13 STAT Phosphorylation-independent Induction of IRF-9 by IFN-β. M. R. Sandhya Rani, Tao Wei, Jennifer Shrock, Ed Croze and Richard M. Ransohoff, Neuroinfl ammation Research Center, Department of Neurosciences, Cleveland Clinic, Cleveland, OH, Bayer Healthcare Pharmaceuticals Inc., Richmond, CA.

14:45 WO1-3 Roles of JAK-STAT Pathway Factors in Antiproliferative Activities of Human IFN-α and IFN-γ: A Comprehensive Assessment in Human Ovarian Adenocarcinoma OVCAR3 Cells. Takaya Tsuno, Josef Mejido, Tongmao Zhao, Angel Morrow and Kathryn C. Zoon, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.

15:00 WO1-1 Dual Regulatory Roles of the Phosphatidylinositol 3-kinase in Interferon Signaling. Surinder Kaur, Antonella Sassano, Ajith M. Joseph, Beata Majchrzak-Kita, Elizabeth A. Eklund, Eleanor N. Fish, Amit Verma, Saskia M. Brachmann, and Leonidas C. Platanias, Robert H. Lurie Comprehensive Cancer Center, North- western University Feinberg School of Medicine, Chicago, IL.

15:15 WO1-7 Similarities and Distinctions of STAT Nuclear Traffi cking. Janaki Iyer, Hui-Chen Chen, Velasco Cimica and Nancy C. Reich, Department of Molecular Genetics & Microbiology, Stony Brook University, Stony Brook, New York, NY.

15:30 WO1-12 The Pathophysiological Actions of Interferon-α in the Central Nervous System are Exacerbrated by the Absence of IRF9. Markus J. Hofer, Wen Li and Iain L. Campbell. School of Molecular and Microbial Biosciences and Bosch Institute, University of Sydney, NSW, Australia.

15:45 WO1-4 Parameters Governing Interferon alpha2/beta Differential Activities. Ignacio Moraga Gonzalez, Josiane Ragimbeau, Gilles Uzé and Sandra Pellegrini, Cytokine Signaling Unit, CNRS URA 1961, Institut Pasteur, Paris, France.


WORKSHOP 2 MARQUETTECYTOKINES IN THE PATHOGENESIS OF INFLAMMATORY DISEASE

Chairpersons: Jennifer Gommerman, University of Toronto (Canada) Josef Schwarzmeier, University of Vienna (Austria)

14:00 WO2-149 Mice in which Human TNF is Mediating both Benefi cial and Deleterious Functions: A Model Comparison of Different Blockade Strategies. A.A. Kruglov, Yu.V. Shebzukhov, A. Kuchmiy, A.R. Galimov, G. Efi mov, S.I. Grivennikov, D.V. Kuprash, S.V. Kozlov, S.A. Nedospasov, German Rheumatism Research Center (DRFZ), Berlin, Germany; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.

14:15 WO2-28 Differential Roles of IL-6 and IL-11 in Infl ammation and Tumori- genesis. Brendan J. Jenkins, Meri Nadjovska, Claire Greenhill, Louise McLeod, Hazel Tye, Catherine Kennedy, Ceri Fielding, Nicholas Topley, Simon A. Jones, Matthias Ernst, and Paul J Hert- zog, Monash Institute of Medical Research, Clayton, Australia.

14:30 WO2-30 Inhibition of IL-23 Prevents Disease in an Inducible Psoriatic- like Mouse Model. Jennifer Towne, Donna Shows, Huyen Dinh, Yu Zhang, Charley Dean, Esther Trueblood, Keith Bailey, John Sims, and Hal Blumberg, Department of Infl ammation Research, Amgen, Seattle, WA.

14:45 WO2-41 TL1A-DR3 Interactions Drive Immunopathology Mediated by Multiple T-cell Subsets. Richard M. Siegel, Erin Kahle, Krishika Acharya, Ivan Fuss, Eddie Wang, and Francoise Meylan, Immunoregulation Unit, NIAMS, NIH, Bethesda, MD. ICS Young Investigator Award

15:00 WO2-34 Mutations in the Interleukin-1 Receptor Antagonist Cause a New Autoinfl ammatory Disease. Seth L Masters, Ivona Aksen- tijevich*, Polly J Ferguson, Matthew G Booty, Arian Laurence, Hang Pham, Deborah L Stone, Edward W Cowen, Nicole Plass, Xinyu Bing, Gillian I Clarke, Kamal Ohson, Hatem I El-Shanti, Annet van Royen, Joost Frenk, Proton Rahman, Elaine F Remmers, Paul Dancey, Daniel L Kastner and Raphaela Goldbach-Mansky, Genetics and Genomics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD. ICS Post-Doctoral Investigator Award

15:15 WO2-112 Regulation of Infl ammatory Responses by IL-17F. Chang SH, Yang XO, Park H, Nurieva R, Shah B, Acero L, Wang YH, Schluns KS, Broaddus RR, Zhu Z, Dong C. Department of Immunology, MD Anderson Cancer Center, Houston, TX. ICS Post-Doctoral Investigator Award

15:30 WO2-32 The Role of IL6-Transsignaling in Acute and Chronic Infl ammation. B. Rabe, Athena Chalaris, Nina Adam, Krzysztof Paliga, Hans Lange, Tamas Laskay, Ceri A. Fielding, Georg H. Waetzig, Dirk Seegert, Anwen S. Williams, Simon A. Jones, Christian Sina, Stefan Rose-John and Jürgen Scheller, Department of Biochem- istry, Christian-Albrechts-University, Kiel, Germany.

15:45 WO2-35 Role of the IFN-inducible Gene IFI16 in the Pathogenesis of Autoimmune Diseases. Gugliesi Francesca, Michele Mondini, Marco De Andrea, Simone Sponza, Rossella Baggetta, Marisa Gariglio, and Santo Landolfo, Department of Public Health and Microbiology, University of Turin, Turin, Italy.





WORKSHOP 3 JOLLIETCYTOKINES AND CHEMOKINES: MECHANISMS OF ACTION

Chairpersons: Alberto Mantovani, Istituto Clinico Humanitas IRCCS (Italy) Eliane Meurs, Institut Pasteur (France)

14:00 WO3-113 Major Differences in the Response of Primary Human Blood Cells to IFN-β. Anette H. H. van Boxel-Dezaire, Joana A. Zula, Yaomin Xu, Richard M. Ransohoff, James W. Jacobberger, and George R. Stark, Department of Molecular Genetics, Cleveland Clinic Foundation, Cleveland, OH.

14:15 WO3-114 A New Composite Cytokine Formed by the Interleukin-27 Subunit P28 and Soluble Receptor CLF Activating Human Natural Killer Cells. Sandrine Crabé, Angélique Guay-Giroux, Dorothée Duluc, Aurélie Tormo, Pascale Jeannin and Jean- François Gauchat, Département de pharmacologie, Université de Montréal, Montreal, QC.

14:30 WO3-116 Cell-specifi c Induction of CXCL9 by IFN-γ is Determined by PU.1. Sally L. Carter, Marcus Müller, Wen Li, Peter M. Manders, Iain L. Campbell, School of Molecular and Microbial Biosciences and the Bosch Institute, University of Sydney, Sydney, NSW, Australia.

14:45 WO3-118 Oncostatin-M Induces Accumulation of Airway Eosinophils and Extracellular Matrix Through STAT6–dependent and –independent Pathways. Dominik K. Fritz, Christine Kerr, Walid Khan, Fernando Botelho, David Smyth, Martin Stampfl i, Carl D. Richards, Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON.

15:00 WO3-119 TGF-β Promotes Th17 Cell Development Through Inhibition of SOCS-3. Hongwei Qin, Lanfang Wang, Charles O. Elson, Sandrine A. Niyongere, Sun Jung Lee, Etty N. Benveniste, Craig L. Maynard, Casey T. Weaver, Kevin Roarty, Rosa Serra, and Yingzi Cong, Department of Cell Biology, University of Alabama, Birmingham, AL. ICS Young Investigator Award

15:15 WO3-120 The IL-1 Family Member IL-1F7 Reduces Innate Immunity by Inhibiting Toll-like Receptor and IL-1 Signaling Pathways. Marcel F. Nold, Claudia A. Nold-Petry, Jarod A. Zepp, Philip Bufl er, and Charles A. Dinarello, Department of Medicine, University of Colorado Health Sciences Center, Denver, CO.

15:30 WO3-121 Differential Control of T-Cell Responses by Classical IL-6 Receptor Signaling and IL-6 Trans-signaling. Gareth W. Jones, Rachel M. McLoughlin, Victoria J. Hammond, Clare R. Parker, John D. Williams, Raj Malhotra, Jürgen Scheller, Stefan Rose- John, Nicholas Topley and Simon A. Jones, Department of Medical Biochemistry and Immunology, School of Medicine, Cardiff University, Cardiff, UK.

15:45 WO3-125 Glycosylated Recombinant Simian Interleukin-7 Provokes Immediate and Massive Chemokine-dependent T-cell Homing in Healthy Rhesus Macaques. Stéphanie Beq, Sandra Rozlan, David Gautier, Raphaelle Parker, Véronique Mersseman, Clémentine Schilte, Brigitte Assouline, Iann Rancé, Pascal Lavedan, Michel Morre and Rémi Cheynier, Département de Virologie, Institut Pasteur, Paris, France.


WORKSHOP 4 DULUTHIMMUNE CELL ACTIVATION AND FUNCTION

Chairpersons: Scott Durum, NIH (USA) Michael Tovey, CNRS-Villejuif (France)

14:00 WO4-148 ‘Re-educating’ Macrophages in Infection and Cancer by Targeting NF-κB. Toby Lawrence, Carol Fong and Thorsten Hagemann, Centre for Cancer and Infl ammation, Institute of Cancer and CR-UK Clinical Centre, Barts and The London School of Medicine and Dentistry, London UK. ISICR Young Investigator Award

14:15 WO4-29 Antagonistic Role of STAT6 for Regulatory T-cells. Svetlana P. Chapoval, Ann E. Kelly-Welch, Elizabeth Smith, and Achsah D. Keegan, Center for Vascular and Infl ammatory Diseases, University of Maryland School of Medicine, Baltimore, MD.

14:30 WO4-152 Negative Feedback Regulation of T-cells: Interleukin 2 and FOXP3 Reciprocity. Zoran Popmihajlov and Kendall A. Smith, Division of Immunology, Department of Medicine, Weill Cornell Medical College, New York, NY.

14:45 WO4-158 Cytokines Control CD4+ CD25+ Foxp3+ Regulatory T-cell Survival and their Mechanism of Suppression. Pushpa Pandiyan and Michael Lenardo, Laboratory of Immunology, NIAID, Bethesda, MD. ICS Post-Doctoral Investigator Award

15:00 WO4-151 Interferon Regulatory Factor-1 Negatively Regulates CD4+CD25+ Regulatory T-cells by Repressing FOXP3. Alessandra Fragale, Lucia Gabriele, Emilia Stellacci, Paola Borghi, Edvige Perrotti, Ramona Ilari, Angela Lanciotti, Anna Lisa Remoli, Massimo Venditti, Filippo Belardelli and Angela Battistini, Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanità, Rome, Italy.

15:15 WO4-31 A Role for IFN-β in Limiting TH17 Cell Accumulation in Multiple Sclerosis. Carole Galligan, Ramtin Rahbar, Beata Majchrzak, Thomas Murooka, Ehtesham Baig, and Eleanor Fish, Toronto General Research Institute, University Health Network, Toronto, ON.

15:30 WO4-154 Interferon-gamma Prevents Death of Bystander Neurons During CD8 T-cell Responses in the Brain. Kirsten Richter, Jürgen Hausmann and Peter Staeheli, Department of Virology, University of Freiburg, Freiburg, Germany.

15:45 WO4-211 Micro-Injection of Inositol Pyrophosphates Induces Apoptosis in Head and Neck Squamous Cell Carcinoma Cells. Bei H. Morrison, Eric Lamarre, Joseph A. Bauer, Judith Drazba, Glenn D. Prestwich, and Daniel J. Lindner, Center for Hematology and Oncology Molecular Therapeutics, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH.




SYMPOSIUM 1 LE GRAND SALON

FUNCTIONS OF INTERFERON STIMULATED GENES

Chairpersons: Ganes Sen, Lerner Research Institute, Cleveland Clinic (USA) Michael David, University of California, San Diego (USA)

16:30 SY1-1 Induction, Functions and Viral Evasion of the ISG56 Family of Genes. Ganes C. Sen, Lenette Lu, Volker Fensterl, Christine White, Michifumi Yamashita, Parama Saikia, Saurabh Chattopadhyay and Saumendra N. Sarkar, Lerner Research Institute, Cleveland Clinic, Cleveland, OH.

17:00 SY1-2 Infl ammation-Induced microRNAs in B-cell Lymphoma. Irene Pedersen, Ana Miletic, Carlo Croce, Kirsten Gronbaek, Robert Rickert and Michael David, University of California, San Diego, La Jolla, CA.

17:20 SY1-3 STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Glen Barber, University of Miami School of Medicine, Miami, FL.

17:40 SY1-4 The Gait System Defi nes a Post-Transcriptional Regulon that limits Myeloid Expression of Infl ammatory Genes. Paul L. Fox, Rupak Mukhopadhyay, Partho Sarothi Ray, Abul Arif, and Jie Jia, Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH.

SYMPOSIUM 2 MARQUETTE / JOLLIET

BIOLOGY AND REGULATION OF THE TNF SUPERFAMILY

Chairpersons: Carl Ware, LaJolla Institute of Allergy and Immunology (USA) Genhong Cheng, University of California, Los Angeles (USA)

16:30 SY2-5 Regulation of Immunity through the LTβ Receptor and HVEM-BTLA Circuit. Carl F. Ware, Tim Cheung, Carl DeTrez, Kirsten Schneider, John Sedy, Claire Jacquin, Satoshi Fukuyama, Hideki Sanjo, Brian Greenberg, Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA.

17:00 SY2-6 Cells and Signals in Models of TNF-driven Pathophysiology. George Kollias, Alexander Fleming Institute, Vari, Athens, Greece.

17:20 SY2-7 TNF-like Proteins in Organogenesis. Marja L. Mikkola, Sylvie Lefebvre, Ingrid Fliniaux, Irma Thesleff, Developmental Biology Program, Institute of Biotechnology, University of Helsinki, Helsinki, Finland.

17:40 SY2-8 Noncanonical NF-κB Activation Requires the Coordinated Assembly of the cIAP1/2-NIK Regulatory Complex by TRAF2 and TRAF3. Genhong Cheng, Brian J. Zarnegar, Yaya Wang, Douglas J.Mahoney, Paul W. Dempsey, Herman H. Cheung, Jeannie He, Travis Shiba, Xiaolu Yang, Wen-chen Yeh, Tak W. Mak, Robert G. Korneluk, Department of Microbiology, Immunology & Molecular Genetics, University of California Los Angeles, Los Angeles, CA.



POSTER DISCUSSION 1 18:00 – 19:30 HOCHELAGA 2

18:15 PD1-78 TREM-1 Expression is Increased in the Synovium of Rheuma- toid Arthritis Patients and Induces the Expression of Pro- infl ammatory Cytokines. Jun Kuai, Bernard Gregory, Andrew Hill, Debra D. Pittman, Jeffrey L. Feldman, Tom Brown, Brenda Carito, Margot O’Toole, Renee Ramsey, Kathleen M. Shields, Jonathan T Beech, Jagdeep Nanchahal, Marc Feldmann, Brian M Foxwell, Fionula M Brennan, Wyeth Research, Departments of Infl ammation, Cambridge, MA.

18:30 PD1-44 The Overexpression of DAP12 Leads to Gain of Osteoclast Function in vitro with Age-related Onset of Osteopenia in vivo. Geneviève Despars, Adrienne Anginot, Eric Vivier, Marlène Mazzorana, and Pierre Jurdic, Cell Biology and Bone Physio- pathology Laboratory, Institut de Génomique Fonctionnelle de Lyon Université de Lyon; Institut Fédératif Biosciences Gerland Lyon Sud; Université Lyon 1, CNRS, INRA, Ecole Normale Supérieure de Lyon, France.

18:45 PD1-57 Neo-Organoid of Mesenchymal Stem Cells Engineered to Secrete a CC-Chemokine Chimeric Fusokine Reverses EAE. Moutih Rafei, Philippe Campeau, Elena Birman, and Jacques Galipeau, Montreal Center for Experimental Therapeutics in Cancer, Jewish General Hospital, McGill University, Montreal, QC.

19:00 PD1-180 Recruitment of Stat1 to Chromatin is Required for Interferon- induced Serine Phosphorylation of Stat1 Transactivation Domain. Iwona Sadzak, Melanie Schiff, Edward Yang, Barbara Schaljo and Pavel Kovarik, Max F. Perutz Laboratories, University of Vienna, Vienna, Austria.

POSTER SESSION 1 18:00 – 19:30 PP 1 – SIGNAL TRANSDUCTION I

PP1-8A Role for JAKs and STATs in Chemoresistance? Catarina Ramos do Carmo, Michael J. Seckl and Ana P. Costa-Pereira, Imperial College Lon-don, Faculty of Medicine, Department of Oncology/SORA, Hammersmith Hospital, London, UK.

PP1-9Type I Interferon-regulated Gene Expression in the Absence of IRF9, STAT1 OR STAT2 in Murine Mixed Glial Cell Cultures. Wen Li, Markus J. Hofer, Sally L. Carter, Dale Hancock, Gareth Denyer, Iain L. Campbell, School of Molecular and Microbial Biosciences, University of Sydney, Sydney, NSW, Australia.

PP1-10X-Linked Inhibitor of Apoposis Protein Inhibits RIG-I Signalling Path-way. Peyman Nakhaei, Thibault Mesplède, Qiang Sun, Simon Leveillé, Robert G. Korneluk and John Hiscott, Molecular Oncology Group, Lady Davis Institute-Jewish General Hospital, McGill University, Montreal, Canada.

PP1-11Nuclear Transport Dynamics of STAT6. Hui-Chen Chen, Nancy C. Reich, Department of Molecular Genetics and Microbiology, Stony Brook University, NY.

PP1-14The Function of MAP-kinase Activated Protein Kinases in Infl uenza A Virus Infection–Linking MAPK Signalling to Protein Kinase R Inhibition.

Christina Luig, Stephan Ludwig, Institute of Molecular Virology, Center for Molecular Biology of Infl ammation (ZMBE), Münster, Germany.

PP1-15Gene and Protein Expression Observed After Treatment of DAUDI Cells with IFN-α2c and IFN-α21β. Joseph Bekisz, Josef Mejido, Timothy Veenstra and Kathryn Zoon, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.

PP1-16IRS1 Expression Enhances the Sensitivity of 32D Cells to Chemo-therapy-induced Cell Death. Holly A. Porter, and Achsah D. Keegan, Center for Vascular and Infl ammatory Diseases, Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD.

PP1-17Identifi cation of IFN-alpha-induced Genes and Proteins that are As-sociated with Antiviral Activity in DAUDI Cells. Hana Schmeisser, Josef Mejido, Kathryn C. Zoon, NIAID, National Institutes of Health, Bethesda, MD.

PP1-18Induction of ISGF3 in Response to Interferon Gamma in Human Cells. Angel N. Morrow, Hana Schmeisser, Takaya Tsuno, and Kathryn C. Zoon, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD.

PP1-19Simultaneous Detection of STAT1, STAT3, and STAT5 Activation in Response to Interferons. Mary M. Brodey, Wei Zheng, Jimin Wang, and Kevin Reagan, Invitrogen Corporation, Camarillo, CA.

PP1-20Alpha Lipoic Acid Attenuates Cadmium-induced Infl ammatory Cytokine Expression and Apoptosis in HepG2 Cells. José G. Macías-Barragán, Miriam R. Bueno-Topete, Juan S. Armendáriz-Borunda, Selene G. Huerta-Olvera, Fernando R. Siller-López, Instituto de Biología Molecular en Medicina y Terapia Génica, Universidad de Guadalajara, México.

PP1-21Functional Analyses of Three Human TYK2 Variants. Josiane Ragim-beau, Milica Gakovic, Maija L. Eloranta and Sandra Pellegrini, Cytokine Signaling Unit, CNRS URA 1961, Institut Pasteur, Paris, France.

PP1-22The dsRNA Binding Protein Pact in Innate Immune Signaling. Christine L. White, Gregory A. Peters, Benjamin K. Dickerman, Avanti Desai and Ganes C. Sen, Department of Molecular Genetics, Cleveland Clinic, Cleveland, OH.

PP1-23Impaired Signaling in Memory T-cells during HIV Infection. Yu Shi, Lydie Trautmann, Yoav Peretz, Joumana Zeidan, Bader Yassine-Diab, Zhong He, Mohamed-Rachid Boulassel, Jean-Pierre Routy, Elias K. Had-dad and Rafi ck-Pierre Sékaly, Laboratory of Immunology, Department of Microbiology and Immunology, Université de Montréal and CR-CHUM, NSERM U743 and CUSM, Montréal, QC.

PP1-24OCT-6 (POU3F1, TST-1, SCIP) is an Interferon-inducible Protein. Elisa-beth Hofmann, Ursula Reichart, Christian Gausterer, Dies Meijer, Math-ias Müller and Birgit Strobl, Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Austria.

PP1-25Role of Syk in IL-4-induced Human Neutrophils. Jamila Ennaciri, Denis Girard, Université du Québec, INRS-Institut Armand-Frappier, QC.

PP1-26Molecular and Genetic Analysis of the Resistance of the Mouse Strain SPRET/Ei to Endotoxemia and Gram-negative Sepsis. Lien Dejager, Iris

HOCHELAGA 2-6& MARQUETTE



Pinheiro, Filip Van Hauwermeiren and Claude Libert, Molecular Mouse Genetics Unit, DMBR, VIB and Ghent University, Ghent, Belgium.

PP 2 – CYTOKINES IN THE PATHOGENESIS OF INFLAMMATORY DISEASE

PP2-33The Role of DCIR in the Development of Autoimmune Diseases. Noriyuki Fujikado, Shinobu Saijo, Tomo Yonezawa, Kazusuke Shimamori, Akina Ishii, Sho Sugai, Hayato Kotaki, Katsuko Sudo, Masato Nose, Yoichiro Iwakura, Center for Experimental Medicine, The Institute of Medical Sci-ence, University of Tokyo, Tokyo, Japan.

PP2-36Serum Cytokine and Chemokine Profi les of individuals with Myalgic Encephalomyelitis (ME) Reveal Distinct Pathogen Associated Sig-natures. Vincent C. Lombardi, Doug Redelman, Darren C. White, Marc Fremont, Kenny DeMeirleir, Daniel Peterson and Judy A. Mikovits, Whit-temore Peterson Institute, Reno, NV, USA; Dept. of Microbiology and Immunology, University of Nevada, Reno, NV.

PP2-37The Identifi cation of Novel CSF-1 Target Genes in Human Macrophages. Katharine M. Irvine, Melanie R. Andrews, Manuel A. Fernandez, Robert G. Parton, Christopher J. Burns, Stephen Su, Andrew F. Wilks, David A. Hume, M. J. Sweet, Institute for Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia.

PP2-38Leishmania Induces Inactivation of the Macrophage AP-1 Transcrip-tion Factor and its Subunits Through its Surface Protease GP63. Irazú Contreras, Ma. Adelaida Gomez, Oliver Nguyen, Robert McMaster and Martin Olivier, Department of Microbiology and Immunology, McGill University, Montreal, QC.

PP2-39Cytokines in Guillain Barre Syndrome. Shripad A. Patil and Arun B.Taly, Dept. of Neuro-Microbiology and Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India.

PP2-40Expression and Function of Schlafen-4 in Macrophage Biology and Infl ammation. Wendy JM van Zuijlen, K Schroder, V Garceau, MJ Sweet, S Kellie, DA Hume, Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia, CRC for Chronic Infl ammatory Diseases, Parkville, Victoria, Australia.

PP2-42Absence of IL-22 Aggravates Dextran-sulfate Induced Colitis. Laure Dumoutier and Jean-Christophe Renauld, Ludwig Institute for Cancer Research, Brussels, Belgium.

PP2-43Adipokines and Tumor Necrosis Factor-α in Peripheral Arterial Occlu-sive Disease. Claudia Gherman, Adriana Muresan, Adriana Filip, Anca Cristea, Aurel Mironiuc, Laura Palcau, Diana Sacui, Surgical Clinic No.2, University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj-Napoca, Romania.

PP2-45Key Role of the Protease ADAM17 in the Biology of Interleukin-6, TNFα and the EGF-Receptor. Stefan Rose-John, Athena Chalaris, Krzysztof Paliga, Karina Reiss, Paul Saftig, Joanna Cichy, and Jürgen Scheller, Department of Biochemistry, Christian-Albrechts-Universität, 24098 Kiel, Germany.

PP2-46Modulation of FoxP3 Expression and Severity of Experimental IBD by Estrogen Receptor Isotype and their Agonist. Rekha Rani Garg, Muham-madreza Sachedina, Fabio Cominelli, Brian K. Reuter, and Theresa T. Pizarro, Digestive Health Research Center, University of Virginia Health System, Charlottesville, VA.

PP2-47Interleukin-22 in Sepsis. Tobias M. Bingold, Elisabeth Ziesché, Bertram Scheller, Christian D. Sadik, Katharina Franck, Lara Just, Sven Sartorius, Mathis Wahrmann, Heimo Wissing, Bernhard Zwissler, Josef Pfeilschift-er and Heiko Mühl, Pharmazentrum frankfurt/ZAFES, General Pharma-cology, Goethe-University School of Medicine, Frankfurt, Germany.

PP2-48Spleen Tyrosine and Tyrosine-protein Kinases are Involved in the Infl ammasome Activation by Hemozoin in Human Monocytes. Marina T. Shio, Myriam Savaria, Martin Olivier, Department of Microbiology and Immunology, Centre for the Study of Host Resistance, McGill University Health Centre, Montréal, QC.

PP2-49Regulation of TLR Mediated Responses in the Peritoneal Cavity. Chantal S Colmont, Mario O Labéta, Anne-Catherine Raby, Barbara Coles, Simon A Jones and Nicholas Topley, Department of Medical Biochemistry and Immunology, Cardiff University, Cardiff, UK.

PP2-50A Humanized BAC Transgenic/Knockout Mouse Model for Human Caspase-12 Polymorphism. Garabet Yeretssian, Michael R. Hayden, Donald W. Nicholson and Maya Saleh, Department of Medicine, Division of Critical Care, McGill University, Montreal, QC.

PP2-52Defi ning Host T-cell Responses in Oral Candidiasis. Heather R. Conti, Fang Shen, Namrata Nayyar, Eileen Stocum, Matthew J. Lindemann, Allen Ho, Patricia Masso-Welch, Mira Edgerton, Sarah L. Gaffen, Dept. of Oral Biology, School of Dental Medicine, University at Buffalo, SUNY, Buffalo NY.

PP2-53CNTF Receptor Activation Modulates Sensitivity to Cold, to TRPA1 Ago-nist and Infl ammation-Induced Hyperalgesia. Marie-Claude Letellier, Jean-Sébastien Walczak, Sandrine Crabé, Marie Gingras, François Ber-thod, Greg Elson, Pierre Beaulieu and Jean-François Gauchat, Départe-ment de pharmacologie, Université de Montréal, Montreal, QC.

PP2-54A Soluble Form of the LDL Receptor Inhibits Hepatitis B Virus Replica-tion in vitro. Ariel Werman, Brent E. Korba, Ben Alkahe, Danit Finkelsh-tein, Sergey Bujanover, Daniela Novick, Ernest Vinocour and Menachem Rubinstein, Dept. of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.

PP2-55Infl ammatory Caspases Modulate Host Response to Malaria. Katherine Labbé, Jenny Miu, Mifong Tam, Mary Stevenson, Maya Saleh, Microbi-ology and Immunology, McGill University, Montreal, QC.

PP2-56Characterization of an Anti-infl ammatory and Immunomodulatory Protein, SJ16, of Schistosoma Japonicum. Shaomin Hu and Ming Chiu Fung, Department of Biology, Chinese University of Hong Kong, Hong Kong, China.

PP2-57Neo-Organoid of Mesenchymal Stem Cells Engineered to Secrete a CC-Chemokine Chimeric Fusokine Reverses EAE. Moutih Rafei, Philippe Campeau, Elena Birman, and Jacques Galipeau, Montreal Center for Experimental Therapeutics in Cancer, Jewish General Hospital, McGill University, Montreal, QC.

PP2-58Effect of Coenzyme Q10 on LPS-induced Secretion of the Pro-infl am-matory Cytokines and Chemotactic Factors in THP-1 Cells. Constance Schmelzer, Gerti Lorenz, Inka Lindner, Frank Döring, Department of Molecular Nutrition, Institute of Human Nutrition and Food Science, University of Kiel, Germany.



PP2-59Myelin-phagocytosing Macrophages in Isolated Sciatic and Optic Nerves Reveal a Unique Reactive Phenotype. Denise van Rossum, Sören Hilbert, Silke Straßenburg, Uwe-Karsten Hanisch and Wolfgang Brück, Institute for Neuropathology, University of Göttingen, Göttingen, Germany.

PP2-60Immunomodulatory Effects of Drug Metabolites: An Unexpected Role of Sulfamethoxazole in the Regulation of Infl ammation. James Li, Howard Yim, Michael Rieder, Davy Lee, Allan Lau, Cytokine Biology Group, Department of Paediatrics and Adolescent Medicine, and Bio-Screen-ing Unit, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China.

PP2-61Gamma Interferon-induced Inhibition of Growth Rickettsia Prowazekii in Fibroblasts is not Alleviated by Addition of Iron-transferrin. Jenifer Turco and Herbert H. Winkler, Department of Biology, Valdosta State University, Valdosta, GA.

PP2-62Impact of Hepatitis B Viral Load on Serum IL-6, MMP-9 and Alpha-feto-protein Levels and their Correlation with Liver Injury in Chronic Hepa-titis B Infection. Ghada F. Helaly, Department of Microbiology, Medical Research Institute, University of Alexandria, Alexandria, Egypt.

PP2-63Paired Perhipheral Blood and Genital Tract Cytokine and Chemokine Levels with Non-protease Inhibitor Based Antiretrovirals in HIV Infect-ed Women. Ajay Wanchu, Ravinder Kaur Sachdeva, Suresh Pallikkuth, Rashmi Bagga, Nancy Malla, Meera Sharma, Department of Internal Medicine, PGIMER, Chandigarh, India.

PP2-64Contribution of cerebral proinfl ammatory cytokines to hepatic encepha-lopathy in experimental acute liver failure: effect of interleukin-1beta receptor and tumor necrosis factor-alpha receptor knockouts. Chantal Bemeur, Paul Desjardins and Roger F. Butterworth, Unité de recherche en neurosciences, Hôpital St-Luc du CHUM, Montréal, QC.

PP2-65Serum Concentration of TNF-α, IL-6, IL-8, and MCP-1 in Retired Workers Exposed to Mineral Dusts. Jae Hoon Shin, Jong Seong Lee, JooHwan Hwang, Byung soon Choi, Center for Occupational Lung Diseases, WAMCO, Ansan, Korea.

PP2-66Quantitative Cytokine and Cytokine Receptors Profi ling with Evidence Biochip Arrays. J. Porter, F.M. McPhillips, V. Toner, A. Beattie, R.I. Mc-Connell, S.P. Fitzgerald, Randox Laboratories Ltd., Crumlin, Northern Ireland, UK.

PP2-67Biological Role of Hepatocyte-derived Interleukin-1 Receptor Antago-nist in a Model of Systemic Infl ammation. Celine Lamacchia, Gaby Palmer, Audrey Benoit, Dominique Talabot and Cem Gabay, Division of Rheumatology and Department of Pathology & Immunology, University of Geneva School of Medicine (CMU), Geneva, Switzerland.

PP2-68Biological Role of Myeloid Cell-derived Interleukin-1 Receptor An-tagonist in Collagen-induced Arthritis. Celine Lamacchia, Gaby Palmer, Audrey Benoit, Dominique Talabot and Cem Gabay, Division of Rheuma-tology and Department of Pathology & Immunology, University of Geneva School of Medicine (CMU), Geneva, Switzerland.

PP2-69Interleukin-20 Induced Cell Death in Renal Epithelial Cells and was Associated with Acute Renal Failure. Hsing-Hui Li, and Ming-Shi Chang,

Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

PP2-70Plasma Concentration sE-selectin in Patients with Postoperative Infec-tious Complications from Gastrointestinal Surgery for Stomach Cancer. Zelenskiy Alexey, Kazakov Sergey, State postgraduate medical educa-tion of the Defense Ministry of Russian Federation, Moscow, Russia.

PP2-71Tumor Cells Induce Interferon Responsive Genes in Primary Endothe-lial Cells in a Polar Fashion. Claudia Nemeth, Herwig P. Moll, Harald Freudenthaler, Anna Zommer, Christine Brostjan, Department of Surgery – Research Laboratories, Medical University of Vienna, Austria.

PP2-72Pirfenidone Blunts Induction of Bleomycin Induced Genes Associated with Idiopathic Pulmonary Fibrosis in Mice. Milton W. Taylor, Takuma Tsukahara, Osman N Ozes, Jena Derrick, Sarah K.Stevens, Lawrence M.Blatt, Department of Biology, Indiana University, Bloomington, IN.

PP2-73Multiplex Immunoassays for the Quantifi cation of Rhesus and Cyno-molgus Monkey Cytokines. Mary M. Brodey, Nina Liu, Jimin Wang, and Kevin Reagan, Invitrogen Corporation, Camarillo, CA.

PP2-74Inhibition by AT-1001 of Epithelial Tight Junction Permeability Caused by Cytokines from PT-Gliadin Stimulated Human PBMC. Malarvizhi Durai, Neil Poloso, Kelly Kitchens, Robert Somerville; Rosa Carrasco, Shobha Gopalakrishnan, Amir Tamiz, Niranjan Pandey and Sefi k S. Alkan, ALBA Therapeutics, Baltimore, MD.

PP2-75Leucine Modulates the Effects of the Walker Tumour’s Proteolysis-in-ducing Factor in C2C12 Muscle Cells. Estela M. Gonçalves, Maria Cris-tina C. Gomes-Marcondes, Laboratory of Nutrition and Cancer, Depart-ment of Physiology and Biophysics, Institute of Biology, State University of Campinas - UNICAMP, Campinas, SP, Brazil.

PP2-76Inhibition of Cyclooxygenase-2 in Severe Acute Pancreatitis: Cytokines Levels and Organ Dysfunction. Chooklin S., Bihalskyy I., Lyba M., Medi-cal University, Lviv, Ukraine.

PP2-77The Role of IgE Antibodies in Protection Against P.falciparum. Reem Mohammed, Marita Troye Bloomberg, Muntasir Eltayeb, Ibrahim Elhas-san, Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan.

PP2-78TREM-1 Expression is Increased in the Synovium of Rheumatoid Arthritis Patients and Induces the Expression of Pro-infl ammatory Cytokines. Jun Kuai, Bernard Gregory, Andrew Hill, Debra D. Pittman, Jeffrey L. Feldman, Tom Brown, Brenda Carito, Margot O’Toole, Renee Ramsey, Kathleen M. Shields, Jonathan T Beech, Jagdeep Nanchahal, Marc Feldmann, Brian M Foxwell, Fionula M Brennan, Wyeth Research, Departments of Infl ammation, Cambridge, MA.

PP2-79Therapeutic Potential of IL-27 for Infl ammatory and Autoimmune Diseases. Yoshiyuki Miyazaki, Hitoshi Nakashima, and Hiroki Yoshida, Department of Biomolecular Sciences, Faculty of Medicine, Saga Uni-versity, Saga, Japan.

PP2-80Low Dose Administration of Cytokines Protects from Allergic Asthma. Marco Palazzo, Silvia Gariboldi, Laura Zanobbio, Giuseppina F Dusio, Valentina Mauro and Cristiano Rumio, MIL- Mucosal Immunity Labora-tory, Department of Human Morphology, Università degli Studi di Milano, Milan, Italy.


PP2-81Mechanism of Action of Sifnalimumab, a Human IFN-α Neutralizing Monoclonal Antibody. R. Cibotti, V. Oganesyan, M. Liang, I. Vainshtein, C. Morris, J. Riggs, W. Dall’Acqua, L. Roskos. P. Kiener and A. J. Coyle, Medimmune, Inc. One Medimmune Way, Gaithersburg, MD.

PP2-82The Activity State of NF-κB is Associated with the Internalization and Intracellular Survival of Staphylococcus Aureus in Endothelial Cells. Javier Oviedo-Boyso, Marcos Cajero-Juárez, Juan J. Valdez-Alarcón, Alejandro Bravo-Patiño and Víctor M. Baizabal-Aguirre, Laboratory of Molecular Immunology, Centro Multidisciplinario de Estudios en Bio-tecnología, Facultad de Medicina Veterinaria y Zootecnia, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Michoacán, México. E-mail: [email protected].

PP2-83Acceleration of Aging-associated Increase in Infl ammatory Markers and Attenuation of the Immune System Among Atomic-bomb Survivors. Tomonori Hayashi, Yoichiro Kusunoki, Yukari Morishita, Hiroko Nagamura, Mayumi Maki, Yoshiko Kubo, Mika Yamaoka, Ikue Hayashi, Kengo Yoshida, Kei Nakachi, Department of Radiobiology/Molecular Epidemiol-ogy, Radiation Effects Research Foundation, Hiroshima, Japan.

PP2-84Different Tumoral Evolution Induces Increase of Proteolysis-inducing Factor (PIF) and Alteration of the Proteolytic System Activities in Young Tumor-bearing Rats. Tatiane Pertile, Maria C.C.Gomes-Marcondes, Department of Physiology and Biophysics, Institute of Biology, State University of Campinas – Unicamp – 13083-800, Campinas/SP, Brazil.

PP2-85Anti-interleukin-6 Receptor Antibody Prevents T-cell Transfer Colitis not only via Suppression of TH17 Differentiation but also via Suppres-sion of TH1 Proliferation. Fumitaka Terabe, Minoru Fujimoto, Satoshi Serada, Jirou Horino, Tsuyoshi Takahashi, Yoshihito Souma, Yuko Matsu-kawa, Teppei Nishikawa, Tomoharu Ohkawara, Barry Ripley, Tadamitsu Kishimoto, and Tetsuji Naka, Laboratory for Immune Signal, National Institute of Biomedical Innovation, Osaka, Japan.

PP2-86Inhibitory Effect of Carpinus Tschonoskii on the Infl ammatory Chemo-kines, MDC and TARC, IFN-γ-stimulated HACAT Human Keratinocytes. Gyeoung-jin Kang, Ji-young Moon, Hye-ja Lee, Eun-jin Yang, Sun-soon Park, Hee-kyoung Kang, Byoung-sam Yoo, and Eun-sook Yoo, Depart-ment of Pharmacology, College of Medicine, Cheju National University, Jeju, South Korea.

PP2-87Effects of Horse Bone Extracts on Induced Postmenopausal Osteoporo-sis in Rats. Sun-Soon Park, Weon-Jong Yoon, Hye-Ja Lee, Gyeong-Jin Kang, Eun-Jin Yang, Sung-mi Kim, Chang-Su Choo, Hee-Kyoung Kang and Eun-Sook Yoo, Department of Pharmacology, College of Medicine, Cheju National University, Jeju, South Korea.

PP2-88Immunomodulatory Production of NO by Cytokines in Algerian Patients with Bowel Disesae. Hayet Rafa, Manel Amri, Mourad Belkhelfa, Houria Saoula, Amira F. Boutaleb, Chafi a Touil-Boukoffa, Team: Cytokines and NOSynthase, Laboratory of Cellular and Molecular Biology, Faculty of Biological Science, USTHB, Algiers, Algeria.

PP2-89Suppression of Pro-infl ammatory Cytokines and Mediators Expression by Brown Algae Sargassum micracanthum Extracts in Murine Macro-phage RAW 264.7 Cells. Weon-Jong Yoon, Kil-Nam Kim, Ji-Young Kim, Hee-Jung Kim, Soo-Yeong Park, Wook Jae Lee, and Chang-Gu Hyun, Jeju Biodiversity Research Institute, Jeju Hi-Tech Industry Development Institute, Jeju, Korea, Department of Pharmacology, College of Medi-cine, Cheju National University, Jeju , South Korea.


PP2-90Modulation of macrophage infi ltration and infl ammatory activity by the phosphatase SHP-1 in virus-induced demyelinating disease. George P. Christophi, Chad A. Hudson, Ross Gruber, Michael Panos, and Paul T. Massa, Department of Neurology and Department of Microbiology & Immunology, SUNY Upstate Medical University, Syracuse NY.

PP2-91The Use of Cytokine Response Profi les to Inform Viral Vaccine Develop-ment. Stacie Lambert, Kathy Wang, Jennifer Woo, George Kemble, MedImmune, LLC, Mountain View CA.

PP2-92IFN Gamma Modulation by IL 18, IL 4 and IL 10 during BEHCET Disease Evolution. Houda Belguendouz, Djamel Messaoudene, Mohammed L. Ahmedi, Karima Lahmar, Fatma Z. Ider, Oussama Medjber, Dahbia Hartani and Chafi a Touil-Boukoffa, “Cytokines & NO Synthases” group, MCB laboratory, FSB, USTHB, Algiers, Algeria.

PP2-93PGE2-mediated Chronic Infl ammation: a Role for IFN-γ? Alex G. Therien, Simon Lord-Dufour, Virginie Bernier, Yves Boie, Jason D. Burch, Patsy Clark, Danielle Denis, Yongxin Han, James R. Mortimer and Marie-Claude Mathieu, Merck Frosst Center for Therapeutic Research, Kirkland, QC.

PP2-94Leucine-rich Diet and Ascorbic Acid Affect the Proteolysis-inducing Factor Level and the Muscle Antioxidant Stress Response in Tumor-bearing Rats. TC Marcondes; BLG Cruz; EM Salomão; MCC Gomes-Mar-condes, Departament of Physiology and Biophysics, Biology Institute, State University of Campinas, Campinas, SP, Brazil.

PP2-95Plasma Derived HBSAG Inhibits Toll-like Receptor-2 Ligand Induced Expression of Interleukin-12 and CD80 in Monocytic Cell Line THP-1. Chen Zhiao, Cheng Yuming, Hu Yuwen, Yuan Zhenghong, Key Laboratory of Medical Molecular Virology, Ministry of Education and Health Shang-hai Medical College, Fudan University, Shanghai, China.

PP2-96Injectable, thermo-reversible and Complex Coacervated Combination Gels Containing IL-1 Receptor Antagonis Inhibits IL-1 BETA-induced MMP-3 Expression in Human Osteoarthritis Chondrocytes. Jae-Bum Jun, Young-In Na, Choong Hyeok Choi, Jang Kyoung Kim and Yong-Hee Kim, Department of Rheumatology, The Hospital for Rheumatic Diseases, Hanyang University, Seoul, Korea

PP2-97Estimation of Cytokine Levels and its Ratio for Autoimmune Pathology, Adenoma and Cancer of Thyroid Glands. Sergei P. Kazakov, Nikolai Ev. Kushlinsky, Research Scientifi c Center, Burdenko Main Military Clinical Hospital, DM, Moscow, Russia.

PP2-98Hyper-induction of COX-2-Mediated Proinfl ammatory Cascade: A Mech-anism for the Pathogenesis of Avian Infl uenza H5N1 Infection. Suki M.Y. Lee, Chung-Yan Cheung, John M. Nicholls, J. S. Malik Peiris, Department of Microbiology, The University of Hong Kong, Hong Kong, China.

PP2-99Induction of Pro-infl ammatory Mediators by H5N1 Infection of Primary Human Lung Microvascular Endothelial Cells. Chung-Yan Cheung, Suki M. Y. Lee, J. S. Malik Peiris, Department of Microbiology, The University of Hong Kong, Hong Kong, China.

PP2-100Creation of Mutant TNF with TNF Receptor-1 Selective Antagonistic Activity for the Development of a Novel Autoimune Disease Drug. Tetsuya Nomura, Yasuhiro Abe, Yasuo Yoshioka, Hiroko Shibata, Hiroyuki Kayamuro, Yohei Mukai, Madoka Taniai, Tsunetaka Ohta, Shinsaku


Nakagawa, Haruhiko Kamada, Shin-ichi Tsunoda and Yasuo Tsutsumi, National Institute of Biomedical Innovation (NiBio), Osaka, Japan; Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.

PP2-101The Role of Interferon Regulatory Factor 3 and p38 in Infl uenza A Virus Induced Pro-infl ammatory Cytokines. Kenrie P. Hui, Suki M. Lee, Chung-yan Cheung, Iris H. Y. Ng, Leo L. M. Poon, Yi Guan, Nancy Y. Ip, Allan S. Lau and JS Malik Peiris, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.

PP2-102WFDC1/PS20: A Novel Viral Permissivity Factor. Erin Rogers, Ehtesham Baig, Raymond Alvarez, James Reading, Anna Vyakarnam, DanLin Jia and John Nicholls and Eleanor Fish, Department of Immunology, Univer-sity of Toronto, Toronto, ON.

PP2-103Experimental Assessment of Photodynamic Therapy with 5,10,15,20-tetrakis- (Methoxyphenyl)-Porphyrins in Rat Walker Tumor. Adriana G. Filip, Simona V. Clichici, Adriana V. Muresan, Claudia Gherman, Doina Daicoviciu, Rodica M. Ion, Simina Dreve, Nicoleta Decea, Remus Moldo-van, Department of Physiology, “Iuliu Hatieganu” University of Medicine and Pharmacy Cluj-Napoca, Romania.

PP2-104Role for Tumor Necrosis Factor-alpha (TNF-α) in Hearing Loss and in Aquaporin-4 (AQP-4) Expression. Min Kyo Jung, Song E. Kim, Sang W. Yeo and Steven K. Juhn, Department of Otolaryngology-HNS, School of Medicine, The Catholic University of Korea, Seoul, Korea.

PP2-105Cytokine Evaluation of Seven Different Respiratory Infections. Matthew C. Groll and Peter Bellos, Quansys Biosciences, Logan, UT. Positive samples from Infl uenza A, B, Parainfl uenza 1,2,3.

PP2-106Strategy for a Robust Preclinical Human Assay to Assess Potential for Cytokine Release Syndrome with Therapeutic Antibodies. Ram Achuthanandam, Peter J. Bugelski, George Treacy and Renold J. Capocasale, Toxicology and Investigative Pharmacology, Centocor R&D, Radnor, PA.

PP2-108Mouse Model of Eczema Vaccination. Jarmila Zajicova and Zora Melkova, Institute of Immunology and Microbiology, 1st Medical Faculty, Charles University, Prague, Czech Republic.

PP2-109Ultra Human Interferons Exhibit Higher Activity than the Standard Interferons in Prevention of Human Papillomavirus Infection in Cells. Barbara Schwartz, Kevin Anton, Dolly Koltchev, Michael Skawinski, William Clark, Thomas Lavoie, Lara S. Izotova, David Lembo, Patricia Day, Susana Pang, John T. Schiller and Sidney Pestka, Department of Molecular Genetics, Microbiology, and Immunology, RWJMS-UMDNJ, Piscataway, NJ.

PP2-110Role of IL21R in the Pathogenesis of Murine Models of SLE. Leslie Lowe, Heath Guay, Tatyana Andreyeva, Christie Damphousse, Nancy Stedman, Laird Bloom, Stephane Olland, Tom Brown, Cheryl Nickerson-Nutter, Mary Collins, and Debbie Young, Wyeth Research: Infl ammation and Biological Technologies, Cambridge, MA.

PP2-111Interleukin-6 Regulates the Severity of Chronic Autoimmune Myocardi-tis Following Coxsackievirus Infection. Maya C. Poffenberger, Nadine Straka, Nahida El Warry, Dianne Fang, Iryna Shanina and Marc S.

Horwitz, Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC.

PP2-375Ingested IFN-Alpha2a Prolongs the ‘Honeymoon’ Phase in New Onset Type 1 Diabetes Mellitus (T1D) in a phase II Randomized clinical trial (RCT). Kristina I. Rother, Rebecca J. Brown, Miriam M. Morales, Elizabeth Wright, Zhigang Duan, C. Campbell, David M. Harlan, Philip R. Orlander, Staley A. Brod, U. Texas Medical School, Department of Inter-nal Medicine and Neurology, Houston, TX, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Bethesda, MD.

PP 3 – CYTOKINES AND CHEMOKINES: MECHANISMS OF ACTION

PP3-115S-nitrosylated S100A8– Novel Anti-infl ammatory Properties. Su Yin Lim, Mark Raftery, Hong Cai, Shane Thomas, Kenneth Hsu and Carolyn L. Geczy, Centre for Infection and Infl ammation Research, Bioanalytical Mass Spectrometry Facility and Centre for Vascular Research, School of Medical Sciences, University of New South Wales, Sydney, NSW Australia.

PP3-117Unaltered Neurological Disease and Mortality in CXCR3-defi cient Mice Infected Intracranially with LCMV-armstrong Strain. Markus J Hofer, Sally L Carter, Marcus Mueller and Iain L Campbell, School of Molecular and Microbial Biosciences and the Bosch Institute, The University of Sydney, NSW, Australia, Department of Neurology, University of Bonn, Germany.

PP3-1222’-5’ Oligoadenylate Synthetase Shares Active Site Architecture with the Archaeal CCA Editing Enzyme. Séverine Torralba, Jelena Sojat and Rune Hartmann, Centre for Structural Biology, Dept. of Molecular Biol-ogy, University of Aarhus, Denmark.

PP3-123Functions of IL-32 in Human Vascular Endothelial Cells. Claudia A. Nold-Petry, Marcel F. Nold, Jarod A. Zepp, Alaine K. Walborn, and Charles A. Dinarello, Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA.

PP3-124Differential Responses to Oncostatin-M in C57BL/6 and BALB/C Mice in vivo. Carl D. Richards, Christine Kerr, Dominik K. Fritz, Andrew D. Row-an2 and Carrie M. Langdon, Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada and 2University of Newcastle, Newcastle, UK.

PP3-126Interferome: The Database of Interferon Regulated Genes. Shamith Samarajiwa, Sam Forster, Katie Auchett, Paul Hertzog, Center for In-nate Immunity and Infectious Diseases, Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia.

PP3-127Cardiotrophin-like Cytokine (CLC) and Epstein-barr Virus Induced Gene 3 (EBI3) Form A Composite Cytokine. Isabelle Cognet, Sandrine Crabe, Aurélie Tormo, Catherine Guillet, Lydie Canier, Sylvie Chevalier, Greg C.A. Elson, Dominique Couez, Odile Devergne, Hugues Gascan and Jean-François Gauchat, Département de pharmacologie, Université de Montréal, Montreal, QC.

PP3-128Interleukin-6 Acts in the Fashion of a Classical Chemokine on Mono-cytic Cells by Inducing Integrin Activation, Cell Adhesion, Actin Polymerization, Chemotaxis and Trans-migration. Thomas Clahsen, Fred Schaper, Department of Biochemistry, RWTH Aachen University, Aachen, Germany.



PP3-129CC Chemokine Receptor 5-dependent Endothelial Progenitor Cell Homing to Skin Wound. Yuko Ishida, Akihiko Kimura, Kouji Matsushima, Naofumi Mukaida, Toshikazu Kondo, Department of Forensic Medicine, Wakayama Medical University, Wakayama, Japan.

PP3-130STAT3 is a Negative Regulator of Type I IFN-induced Antiviral Respons-es. Wei-Bei Wang and Chien-Kuo Lee, Graduate Institute of Immunol-ogy, National Taiwan University, Taipei, Taiwan.

PP3-131Cytokine Responses of Naïve T-cells Requires Special Permission by Accessory Cells. Noriko Sato, Thomas A. Waldmann, Yutaka Tagaya, Metabolism Branch, National Cancer Institute, NIH, Bethesda, MD.

PP3-132Oncostatin M Induces Interleukin 17 Receptor A and Synergistic Re-sponses to Interleukin-17 in Mouse Aortic Adventitial Fibroblasts. Matt Scott, Jackie Beitz, Bernardo Trigatti and Carl D. Richards, Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON.

PP3-133Combination of Interferon-gamma and Transforming Growth Factor-beta (TGF-beta) Results in an Altered Gene Expression Profi le. Milton W. Taylor, Oman N.Ozes, Takuma Tsukahara, Lawrence Blatt, Department of Biology, Indiana University, Bloomington and InterMune, Brisbane, CA.

PP3-134Neutralizing Monoclonal Antibodies Against Type I Interferon can Trigger an “Interferon-like” Response: Involvement of the Fc Domain. Herwig P. Moll, Harald Freudenthaler, Anna Zommer, Elisabeth Buch-berger, Christine Brostjan, Department of Surgery – Research Laborato-ries, Medical University of Vienna, Austria.

PP3-135Resveratrol Inhibits Foam Cell Formation via NADPH Oxidase 1-Medi-ated ROS and MCP-1. Kheewoong Baek, Dae-Weon Park, Sung-Chul Park, Yoon-Ki Park, Jae-Ryong Kim, Suk-Hwan Baek, Aging-associated Vascular Disease Research Center, Department of Biochemistry & Molecular Biology, College of Medicine, Yeungnam University, Daegu, South Korea.

PP3-136Ca2+-Independent Phospholipase A2 Participates in Toll-Like Receptor 4-Induced MCP-1 Release. Sun-Hye Lee, Eun-Jung Lim, Jae-Ryong Kim, Suk-Hwan Baek, Aging-associated Vascular Disease Research Center, Department of Biochemistry & Molecular Biology, College of Medicine, Yeungnam University, Daegu, South Korea.

PP3-137Specifi c Determination of Human IFN-α8: Establishment of the Sub-tupe-specifi c Monoclonal Antibodies and Elisa Systems. Chie Ushio, Harumi Ariyasu, Tohru Kayano, Hitomi Ohta, Miho Aga, Toshio Ariyasu, Tsunetaka Ohta and Shigeharu Fukuda, Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc., Okayama, Japan.

PP3-138Molecular Mechanisms of Interleukin-27-induced Cytokine Production in Human Monocytic Cells. Christina Guzzo, Nor Fazila Binti Che Mat and Katrina Gee, Department of Microbiology and Immunology, Queen’s University, Kingston, ON.

PP3-139The Absence of IL-6/STAT3 Signals Enhanced Arsenite-induced Renal Injury by Promoting Autophagy of Tubular Epithelial Cells with Aber-rant ERK Activation. Akihiko Kimura, Yuko Ishida, Naofumi Mukaida and Toshikazu Kondo, Department of Forensic Medicine, Wakayama Medical University, Wakayama, Japan.

PP3-140Protective Role of CX3CR1-medicated Signal Pathway in Clostridium Diffi cile Toxin A-induced Enteritis. Masanori Inui, Yuko Ishida, Akihiko Kimura, Naofumi Mukaida, Toshikazu Kondo, Department of Molecular Immunology, Institute of Advanced Medicine, Wakayama Medical Uni-versity, Wakayama, Japan.

PP3-141Dissecting Interactions Between Interleukin-1 Alpha Histone Acet-yltransferase Complexes. Blanka Vicenova, Miroslava Buryskova, Ladislav Burysek, Martin Pospisek, Dept. of Genetics and Microbiology, Faculty of Science, Charles University in Prague, Czech Republic.

PP3-142HSP70 Dependent Zinc Protection Against TNF-induced Lethal Infl am-mation Allows for a Safer Antitumor Therapy. Filip Van Hauwermeiren, Claude Libert, Department for Molecular Biomedical Research, VIB; Ghent, Belgium.

PP3-143MARCH1 E3 Ubiquitin Ligase in Pro-infl ammatory Cytokine Response: What is its Role in Infl ammation Regulation? Jessy Tremblay, Marie-Claude Bourgeoie-Daigneault, Jacques Thibodeau, Gabrielle Huppé, Viktor Steimle, Département de Microbiologie et Immunologie, Univer-sité de Montréal, Montréal, QC.

PP3-144Molecular Mechanisms of MHC Class II Inhibition by the MARCH1 Ubiquitin Ligase in Response to IL-10. Marie-Claude Bourgeois-Daigneault, Gabrielle Huppé, Jessy Tremblay, Viktor Steimle, and Jacques Thibodeau, Department of Microbiology and Immunology, University of Montreal, QC.

PP3-145IL-33 is a Potent Activator of Human Eosinophils. Michael R. Comeau, Bo-Rin Park Yoon, Heidi K. Jessup, Penny Anders, Dave Swart, Molly D. Smithgall and Dirk E. Smith, Infl ammation Research, Amgen, Inc. Seattle, WA.

PP3-146A GMCSF and CCL2 Fusion Chimera Induces Apoptosis in CCR2 Ex-pressing Lymphomyeloid Cells and Promotes Xenotolerance. Moutih Rafei, Yamina Berchiche, Jian Hui Wu, Elena Birman, Nikolaus Heveker, and Jacques Galipeau, The Montreal Center for Experimental Therapeu-tics in Cancer, Montreal, QC.

PP3-147Lymphotoxin-α β Heterotrimers are Shed from the Surface of Activated Human Lymphocytes and Circulate in Human Serum. Judy Young, Allen Nguyen, Xin Yu, Eugene Chiang, Racquel Corpuz, JianPing Yin, Catherine Kung, Richard Vandlen, Dan Yansura, Laura DeForge, Wai Lee Wong, Jane Grogan, Department of Assay and Automation Technology, Genen-tech Inc., South San Francisco, CA.

20:00 EVENING AT NOTRE DAME BASILICA OF MONTREAL



Tuesday, October 14, 2008


INFLAMMATION AND CANCER

Chairpersons: Giorgio Trinchieri, National Cancer Institute, (USA) Maya Saleh, McGill University (Canada)

08:30 PL2-8 Molecular Pathways Linking Infl ammation and Cancer. Alberto Mantovani, Istituto Clinico Humanitas IRCCS, University of Milan, Milan, Italy.

09:00 PL2-9 Toll-like Receptors in Oncogenesis. Ruslan Medzhitov, Department of Immunology, Yale University School of Medicine, New Haven, CT.

09:30 PL2-10 Induction of Innate Immune Responses Through Nalp3 Infl ammasome Sensing of Asbestos and Silica. Jurg Tschopp, Department of Biochemistry, University of Lausanne, Epalinges, Switzerland.

10:00 PL2-11 Role of Infl ammatory Caspases in Mucosal Immunity, Colitis and Colorectal Cancer. Maya Saleh, Department of Medicine, McGill University, Montreal, QC.


11:00 PL2-12 IL-7 Paralyses Inhibitory Networks, Potently Boosts Autoimmunity and Viral vaccine Induced Tumor Immune Rejection. Thomas Calzascia*, Marc Pellegrini*, Albert Lin, Kristine M Garza, Alisha R Elford, Arda Shahinian, Pamela S Ohashi & Tak W Mak, University Health Network, University of Toronto, Princess Margaret Hospital, Toronto, Canada.

11:30 PL2-13 Diverse Roles of STAT3 Signaling in Cancer. Hua Yu and Richard Jove, Tumor Immunology and Molecular Medicine, Beckman Research Institute, City of Hope Cancer Center, Duarte, CA.

12:00 PL2-14 The Mechanism of Interferon Gene Transcription in Dendritic Cells. Keiko Ozato, Prafullakumar Tailor, Lakshimi Ramakrishna, Tsung Hsien Chang, Toru Kubota, Mayumi Matsuoka and Herbert Morse, C., Program in Genomics of Differentiation, NICHD, National Institutes of Health, Bethesda, MD.



WORKSHOP 5 MARQUETTEGENE REGULATION: TRANSCRIPTIONAL AND POST-TRANSCRIPTIONAL MECHANISMS

Chairpersons: Tom Hamilton, Cleveland Clinic (USA) Raymond Kaempfer, Hebrew University (Israel)

14:00 WO5-170 IL-17 Uses a Distinct Signaling Pathway to Prolong Chemokine mRNA Half-life. Justin Hartupee, Shyamasree Datta, Michael Novotny, Dongxu Sun, Paul Pavicic, and Thomas Hamilton, Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH.

14:15 WO5-171 The Suppressor of Cytokine Signaling 1, a New Link Between p53, DNA Damage and Senescence. Viviane Calabrese, Frédérick A. Mallette, Xavier Deschênes-Simard, Sheela Ramanathan, Julien Gagnon, Adrian Moores, Subburaj Ilangu- maran and Gerardo Ferbeyre, Department of Biochemistry, Faculty of Medicine, University of Montreal, Montreal, QC. (also PP5-171)

14:30 WO5-172 Regulation of TNFα Gene Transcription at the Post-initiation Step. Megan A. Kennedy, Sergei Nechaev, Daniel A. Gilchrist, Ginger W. Muse, Yurii Chinenov, Karen Adelman and Inez Rogatsky, Hospital for Special Surgery and Dept. of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY.

14:45 WO5-173 ssRNA Viruses Inactivate P53 and Induce Noxa-dependent Apoptosis via Post-Translational Modifi cations of IRF-1, IRF-3 and CREB. C. Lallemand, B. Blanchard, P. Lebon, E. May and M.G. Tovey, Laboratory of Viral Oncology, FRE2937 CNRS, Institut André Lwoff, Villejuif, France.

15:00 WO5-174 IRAK2 is Critical for LPS-mediated Post-transcriptional Control. Hui Xiao, Youzhong Wan, Tae Whan Kim, Katarzyna Bulek, Sujan Chaudhuri, Barsanjit Mazumder, George R Stark, James Thomas, Xiaoxia Li, Department of Immunology, Cleveland Clinic Founda- tion, Cleveland, OH.

15:15 WO5-175 Opposite Transcriptional Effects of Interferon Regulatory Factor 3 on Differential Human Interferon-A Gene Expresssion. Pierre Génin, Rongtuan Lin, John Hiscott and Ahmet Civas, UPR 2228 - CNRS, Laboratoire de Régulation Transcriptionnelle et Maladies Génétiques, UFR Biomédicale des Saints-Pères, Université Paris Descartes, Paris, France.

15:30 WO5-176 Identifi cation of a Novel Enhancer Region in the Distal Promoter Region of the Human Interferon-Lambda1 Gene. Scott J.P. Thomson, FuiGoon Goh, Helen Banks, Brian Foxwell, Sergei V. Kotenko and Irina A. Udalova, Kennedy Institute of Rheumatol- ogy, Imperial College, London, UK.

15:45 WO5-177 Multiple Intracellular Signaling Pathways Contribute to Synergistic TLR Ligand-induced Cytokine Gene Expression in Human Monocyte-derived Dendritic Cells. Sanna Mäkelä, Mari Strengell, Taija Pietilä, Pamela Österlund and Ilkka Julkunen, Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland.



WORKSHOP 6 LE GRAND SALONCONTROL OF CELL GROWTH AND DEATH IN CANCER AND HEMATOPOIESIS

Chairpersons: Michele Barry, University of Alberta (Canada) Nancy Reich, Stony Brook University (USA)

14:00 WO6-195 NF-κB Signaling is Essential in Lung Adenocarcinoma. Etienne Meylan, Alison Dooley, Erin Turk and Tyler Jacks, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA.

14:15 WO6-196 Defi ciency of the Soluble Pattern Recognition Receptor Pentraxin-3 Increases Susceptibility to Tumor Growth and Metastasis. Virginia Maina, Andrea Doni, Cecilia Garlanda and Alberto Mantovani, Laboratory of Immunology and Infl ammation, Istituto Clinico Humanitas, Rozzano, Milan, Italy.

14:30 WO6-197 The Antiapoptotic Protein G1P3 (ISG 6-16) in Survival Signaling in Breast Carcinoma: Cytokine and Endocrine Cross Talk. Venugopalan Cheriyath, Barbara S. Jacobs, Dustin G. Thomas, Perry Evangelista and Ernest C. Borden, Taussig Cancer Institute, Center for Hematology and Oncology Molecular Therapeutics, Cleveland Clinic, Cleveland, OH.

14:45 WO6-198 Activated NOTCH2 Links Protein Kinase C Delta (PKC-δ) to the Expression of CD23 in Chronic Lymphocytic Leukemia (CLL) Cells. Josef D. Schwarzmeier, Rainer Hubmann, Martin Hilgarth, Susanne Schnab, Dita Demirtas, Katrina Vanura, Trang Le, Ulrich Jäger and Medhat Shehata, Clinic of Internal Medicine I, Department of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria.

15:00 WO6-199 Targeting the Apoptotic Pathway with BCL-2 Inhibitors Sensitizes Primary Chronic Lymphocytic Leukemia to VSV- induced Oncolysis. Vanessa F. Tumilasci, Stephanie Oliere, John Bell and John Hiscott, Lady Davis Institute - Jewish General Hospital, McGill University, Montreal, QC.

15:15 WO6-200 IL-9 Inhibits Corticoid-induced Expression of the BH3-only Protein BMF in Mouse Thymic Lymphomas Via the JAK-STAT Pathway. Amel Tounsi and Jean-Christophe Renauld, Ludwig Institute for Cancer Research, Brussels, Belgium.

15:30 WO6-201 The Lnk Adaptor Protein Negatively Regulates Specifi c SCF Biological Responses in Primary Hematopoietic Cells. Clotilde Simon, Elisabetta Dondi, Amandine Chaix, Paulo de Sepulveda, Terrance J. Kubiseski, Nadine Varin-Blank and Laura Velazquez, Institut Cochin, Université Paris Descartes, CNRS, Paris, France.

15:45 WO6-202 Interferon Regulatory Factors 4 is Involved in Epstein-Barr Virus-mediated Transformation of Human B Lymphocytes. Dongsheng Xu, Lingjun Zhao, Luis Del Valle, Judith Miklossy, and Luwen Zhang, Nebraska Center for Virology, School of Biological Sciences, University of Nebraska, Lincoln, NE.




WORKSHOP 7 DULUTHSTRUCTURE AND FUNCTION OF CYTOKINES AND THEIR RECEPTORS

Chairpersons: Paul Hertzog, Monash University (Australia) John Sims, AMGEN (USA)

14:00 WO7-217 Identifi cation of Functional Roles for both IL-17RB and IL-17RA in Mediating IL-25 Induced Activities. Erika A. Rickel, Lori A. Siegel, Bo-Rin P. Yoon, James Rottman, David Kugler, David Swart, Penny Anders, Joel E. Tocker, Michael R. Comeau, and Alison L. Budelsky, Department of Infl ammation Research, Amgen, Seattle, WA.

14:15 WO7-218 Mechanism of TOLL/IL-1 Receptor Domain Dimerization and Signaling Revealed by the Crystal Structure of MYD88. Greg A. Snyder, Jiansheng Jiang and Tsan Xiao, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.

14:30 WO7-219 Regulation of Myelopoiesis Through Syntenin-mediated Modulation of IL-5 Receptor Output. Jeffrey M. Beekman, Liesbeth P. Verhagen, Niels Geijsen and Paul J. Coffer, Molecular Immunology Lab, Dept of Immunology, Dept. of Pediatric Immunology, University Medical Centre Utrecht, Utrecht, The Netherlands.

14:45 WO7-220 Antiviral Potency of Interferon Lambda and Identifi cation of Amino Acids that are Important for the Antiviral Activity of Interferon Lambda II. Hans Henrik Gad, Christoffer Dellgren, Ole J Hamming, Susanne Vends & Rune Hartmann, Centre for Structural Biology, Department of Molecular Biology, University of Aarhus, Århus C, Denmark.

15:00 WO7-221 Structure-function Characterization of Type I Interferon Receptor Signaling Regulation. Nicole A de Weerd, Rebecca Piganis, Leyla Zaker-Tabrizi, Hugh Reid, Jennifer Fenner, Susie Noppert, Jodee Gould, Bernadette Scott, Jamie Rossjohn, W Zhao, C Lee, C Plumlee, Christian Schindler, Paul J Hertzog, Centre for Innate Immunity and Infectious Disease, and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia.

15:15 WO7-222 Forced Dimerization of gp130-receptor Homo and Heterodimers Leads to Constitutive Activation and Cytokine Independent Growth. J. Suthaus, A. Tillmann, C. Stuhlmann-Laeisz, I. Lorenzen, S. Rose-John and J. Scheller, Department of Bio- chemistry, Christian-Albrechts-Universität, Kiel, Germany.

15:30 WO7-223 IL-22R, IL-10R2 and IL-22BP Binding Sites are Topologically Juxtaposed on Adjacent and Overlapping Surfaces of IL-22. Paul W. Wu, Jing Li, Sreekumar R. Kodangattil, Deborah P. Luxenberg, Frann Bennett, Margot Martino, Mary Collins, Kyriaki Dunussi-Joannopoulos, Davinder S. Gill, Neil M. Wolfman, Lynette A. Fouser, Wyeth Research-Infl ammation, Cambridge, MA.

15:45 WO7-224 The Role of TRAF2 Binding to the Type I IFN Receptor in Alterna- tive NFκB Activation and Antiviral Response. Chuan He Yang, Aruna Murti, Susan R. Pfeffer, Meiyun Fan, Ziyun Du & Lawrence M. Pfeffer. Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, TN.


WORKSHOP 8 JOLLIETPATHOGEN EVASION OF THE HOST CYTOKINE RESPONSE

Chairpersons: Michael Gale Jr., University of Washington (USA) Karen Mossman, McMaster University (Canada)

14:00 WO8-248 Ebola Virus Protein VP35 Inhibits Activation of the Interferon- inducible Kinase PKR by RNA. Maayan Eitan, Farhat Osman, Lise Sarah Namer, Einav Eliahu, Yona Banai, Raymond Kaempfer, Department of Molecular Virology, Faculty of Medicine, The Hebrew University of Jerusalem, Israel.

14:15 WO8-237 Reovirus Inhibits Interferon Signaling Through a Novel Mechanism Involving Nuclear Accumulation of IRF9. Barbara Sherry, Jennifer Zurney, Takeshi Kobayashi, Geoffrey H. Holm, and Terence S. Dermody, Departments of Molecular Biomedical Sciences and Microbiology, North Carolina State University, NC.

14:30 WO8-238 Innate immune response triggered by infl uenza A virus is negatively regulated by suppressor of cytokine signaling (SOCS)1 and SOCS3 through a RIG-I/IFNAR1-dependent pathway. Julien Pothlichet, Michel Chignard, and Mustapha Si-Tahar, Unité Défense Innée et Infl ammation, Institut Pasteur, Paris, France.

14:45 WO8-239 PML is Cleaved and Degraded in EMCV-infected Cells. Bouchra M’chichi, Tarik Regad, Laurent Dianoux, Yann Percherancier and Mounira Chelbi-Alix, CNRS FRE 2937, Institut André Lwoff, Villejuif, France.

15:00 WO8-240 Identifi cation of Non-assigned, Non-homologous Virus Genes Inhibiting Interferon Responses. Correia S, Reis AL, Leitão A, Goodbourn S, Parkhouse RME, Instituto Gulbenkian de Ciência, Oeiras, Portugal.

15:15 WO8-241 Regulation of mRNA Processing Genes and Post-initiation Regulation of Transcription by M. Tuberculosis and by IFNγ Stimulation After Infection. Richard Pine, Yaming Qiao, Jeff Cheng, and Antony Canova, Public Health Research Institute, University of Medicine and Dentistry of New Jersey - New Jersey Medical School, Newark, NJ.

15:30 WO8-242 SHP-1-mediated IRAK-1 Inactivation Inhibits LPS-induced Macrophage Functions During Leishmaniasis. Issa Abu Dayyeh, Benoit Cousineau, and Martin Olivier, Department of Micro- biology and Immunology, McGill University, Montréal, QC.

15:45 WO8-243 T-cell Responses in Heliobacter-induced Gastric Preneo- plastic Pathology. Ayca Sayi, Esther Kohler, Iris Hitzler and Anne Mueller, Institute of Molecular Cancer Research, Faculty of Medicine, University of Zurich, Zurich, Switzerland.





microRNA REGULATION OF CYTOKINE GENE EXPRESSION

Chairpersons: Bryan Williams, Monash Institute for Medical Research (Australia) Robert Silverman, Cleveland Clinic (USA)

16:30 SY3-9 Stimulation of Innate Immunity by Short Interfering and micro RNAs. Bryan RG Williams, Michael P Gantier, Stephen Tong, Dakang Xu, and Anthony J Sadler, Centre for Cancer Research, Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia.

17:00 SY3-10 Role of the miR-200 Family in Mediating EMT in Response to TGF-β. Philip A. Gregory, Cameron P. Bracken, Andrew G. Bert, Emily L. Paterson, Natasha Kolesnikoff, Gelareh Farshid, Yeesim Khew-Goodall and Gregory J. Goodall, Hanson Institute, Institute of Medical and Veterinary Science, Adelaide, Australia.

17:20 SY3-11 Role of Small RNAs Generated by RNase L in Antiviral Innate Immunity. Robert H. Silverman, Beihua Dong, Michael Gale, and Krishnamurthy Malathi, Department of Cancer Biology, Cleveland Clinic, Cleveland, OH.

17:40 SY3-12 The Role of miRNAs in the Regulation of Interferon-gamma Gene Expression. Ram Savan, Rajesh Yalamanchili, Shakeeb Hakim and Howard A. Young, Laboratory of Experimental Immunology, Center for Cancer Research, National Cancer Institute, Frederick, MD.


BIOLOGY AND REGULATION OF TH17 CELLS AND IL17

Chairpersons: Sarah Gaffen, SUNY-Buffalo (USA) John O’Shea, NIH (USA)

16:30 SY4-13 Structure and Function of the IL-17 Receptor. Sarah L. Gaffen, Division of Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA.

17:00 SY4-14 Cytokine Regulation of Th17 and Tfh Cell Differentiation. Chen Dong, Department of Immunology, MD Anderson Cancer Center, Houston, TX.

17:20 SY4-15 Role of IL-17 and Related Cytokines in Experimental Erosive Arthritis. Wim B van den Berg, Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.

17:40 SY4-16 The Critical Role of Epithelial-derived Act1 in IL-17- and IL-25-mediated Pulmonary Infl ammation. Shadi Swaidani, Katarzyna Bulek, Zizhen Kang, Caini Liu, Yi Lu, Mark Aronica, Xiaoxia Li, Department of Immunology, Cleveland Clinic, Cleveland, OH.

18:00 SY4-17 Cytokine Signaling and T-cell Differentiation. John O’Shea, National Institutes of Health, Bethesda, MD.



18:15 PD2-247 A Vaccinia Virus Deletion Mutant Reveals Additional Inhibitors of NFκB. Katharine Fagan, Brianne Couturier, Nick van Buuren, Crystal Harmon, Joanna Shisler and Michele Barry, Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada; Department of Microbiology, University of Illinois, Urbana, IL.

18:30 PD2-244 HIV-1 Antagonizes Innate Antiviral Signaling Pathways by Targeting Interferon Regulatory Factor-3 (IRF-3). Brian Doehle and Michael Gale Jr., Department of Immunology, University of Washington, Seattle, WA.

18:45 PD2-259 Antagonism of the Innate Immune Response by Human Rhinovirus 1a. Jennifer Drahos and Vincent Racaniello, Department of Microbiology, Columbia University, New York, NY.

19:00 PD2-225 Biological Activities and Detection of Cynomolgus Interferon-α Subtypes. Doranelly H. Koltchev, Michael Skawinski, Diane Vy, Xiao-Hong Lin, Sara Crisafulli, Karlene Moolchan, Lara Izotova, Edward Dolphin, Thomas B. Lavoie, William Clark, Ronald G. Jubin and Sidney Pestka, PBL InterferonSource, Piscataway, NJ.

19:15 PD2-227 Design of High Affi nity Interleukin-6 and gp130 Variants: Implications for Cytokine-receptor Assembly. Nina Adam, Stephanie Tenhumberg, Georg H. Waetzig, Athena Chalaris, Björn Rabe, Jan Suthaus, Dirk Seegert, Jürgen Scheller, Stefan Rose-John and Joachim Grötzinger, Institute of Biochemistry, Christian-Albrechts-University, Kiel, Germany.

POSTER SESSION 2 18:00 – 19:30 PP 4 – IMMUNE CELL ACTIVATION AND FUNCTION

PP4-150Signaling Via LTbR & HVEM-BTLA Pathways Control Dendritic Cell Homeostasis. Carl De Trez, Kirsten Schneider, Sukwon Ha, Chris A. Benedict, Carl F. Ware, Laboratory of Parasitology, Université Libre de Bruxelles, Brussels, Belgium; Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA.

PP4-153A Novel Antigen Presenting Cell Population (VAP) Modulates Type 2 Immunity Against Infl uenza Virus Infection. Jae-Kwang Yoo, Carole Galligan, Daniel Burke, Eleanor N. Fish, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada.

PP4-155The Immunomodulatory CD300A Receptor is Differentially Expressed on Human TH1 AND TH17 Cells. Francisco Borrego, Sriram Narayanan, Xiaobin Tang, Yelina Alvarez and John E. Coligan, Receptor Cell Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD.

PP4-156Lung Immune Semaphorins and their Receptors. Elizabeth Smith, Michael M. Lipsky, Louis J. DeTolla, Jr., Jack A. Elias, Achsah D. Keegan, Svetlana P. Chapoval, Center for Vascular and Infl ammatory Diseases, Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD.

PP4-157Pulmonary Cytokine Microenvironment Prevents Alveolar Macro-phages to Display Endotoxin Tolerance. Francois Philippart, Catherine

Fitting, Jean-Marc Cavaillon, Institut Pasteur, 28 rue Dr. Roux, 75015 Paris, France.

PP4-159Aryl Hyrdocarbon Receptor Participates in TH17 Cell Differentiation Through Negatively Regulating STAT1 Activation. Akihiro Kimura, Tet-suji Naka and Tadamitsu Kishimoto, Laboratory of Immune Regulation, Graduate School of Frontier Biosciences, Suita city, Osaka, Japan.

PP4-160A Transient Breach in the Epithelial Barrier Leads to Regulatory T-Cell Generation and Resistance to TNBS-Colitis Induction. Monica Boirivant, Antonello Amendola, Alessia Butera, Massimo Sanchez, Lili Xu, Mar-iarosaria Marinaro, Atsushi Kitani, Claudia Di Giacinto, Warren Strober, Ivan J. Fuss, Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, Bethesda, MD.

PP4-161The Role of Lymphotoxin-beta-receptor Signaling in Dendritic Cell Function. Leslie Summers deLuca, Yunfei Gao, Douglas D. McCarthy, Lesley Ward, and Jennifer L. Gommerman, Department of Immunology, University of Toronto, Toronto, ON.

PP4-162Methyl Dehydro-jasmonate(J2) Expression Supresses the Production of Infl ammatory Mediators by Down-regulating NF-ΚB, JNK STAT1 Ex-pression. Hye-Ja Lee, Hung-The Dang, Eun-Jin Yang, Weon-Jong Yoon, Gyeoung-Jin Kang, Sun-Soon Park, Hee-Kyoung Kang, Jee H. Jung, and Eun-Sook Yoo, Department of Pharmacology, College of Medicine, Cheju National University, Jeju, South Korea.

PP4-163Regulation of IL-4R Signaling in TH17 Cells. Laura A. Tesmer, Sujata Sarkar, David A. Fox, Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI.

PP4-164Relationship Between Regulatory T-cell Infi ltration and Progression of Different Tumors Assessed by High-density Tissue Microarray. Kazuya Nagano, Tomoaki Yoshikawa, Toshiki Sugita, Hiromi Nabeshi, Sunao Imai, Kensuke Suzuki, Junya Fukuoka, Shinsaku Nakagawa, Yasuhiro Abe, Haruhiko Kamada, Shin-ichi Tsunoda, and Yasuo Tsutsumi, Laboratory of Pharmaceutical Proteomics, National Institute of Biomedi-cal Innovation; Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.

PP4-165Higher effi cacy of Peg-IFN-α2 ribavirin combined therapy in HCV-in-fected patients with functional myeloid dendritic cells (MDC). Ian Gaël Rodrigue-Gervais, Hawley Rigsby, Bernard Willems and Daniel Lamarre, Centre Hospitalier de l’Université de Montréal; INSERM Unité 743, Hôpital Saint-Luc, Montréal, Québec, Canada; Département de Microbi-ologie-Immunologie, Université de Montréal, Montréal, QC.

PP4-166p50 NF-κB Overexpression in Tumor Associated Macrophages Inhibits M1 Infl ammatory Responses and Antitumor Resistance. Chiara Porta, Monica Rimoldi, Alberto Mantovani, Antonio Sica, Fondazione Humani-tas per la Ricerca, Rozzano, Italy.

PP4-167Elite Controllers are Enriched with HIV-Specifi c Cells Expressing CD160 But Lacking PD1. Yoav Peretz, Yu Shi, Zhong He, Lydie Trautmann, Bader Yassine Diab, Elias Haddad and Rafi ck-Pierre Sékaly, Department of Mi-crobiology and Immunology, University of Montreal (CHUM). Montréal, QC.

PP4-168Characterization of the Potential Cross-talk Between Human Phago-cytes and TH17 Cells. Martin Pelletier and Marco A. Cassatella, Depart-ment of Pathology, Section of General Pathology, University of Verona, Verona, Italy.


HOCHELAGA 2-6& MARQUETTE



PP4-169Gene-Silencing of Reversion-induced LIM Protein Compromises Responses to Interleukin-16 in Jurkat T-cells. Mark Lee, Dannon Martin, Tiffany King, Biology Department of Spelman College, Atlanta, GA.

PP 5 – GENE REGULATION: TRANSCRIPTIONAL AND POST-TRANSCRIPTIONAL MECHANISMS

PP5-171The Suppressor of Cytokine Signaling 1, a New Link Between p53, DNA Damage and Senescence. Viviane Calabrese, Frédérick A. Mallette, Xavier Deschênes-Simard, Sheela Ramanathan, Julien Gagnon, Adrian Moores, Subburaj Ilangumaran and Gerardo Ferbeyre, Department of Biochemistry, Faculty of Medicine, University of Montreal, Montreal, QC.

PP5-178Changes in Gene Expression induced by Pegintron Plus Ribavirin in PBMC of Hepatitis C Patients During the First 10 Weeks of Treatment. Milton W. Taylor, Takuma Tsukahara, Jeanette N. McClintick, Howard J. Edenberg, Paul Kwo, Department of Biology, Indiana University, Bloom-ington, IN.

PP5-179A Central Role for C/EBP-β (NF-IL6) in Regulating the Expression of Metastasis Associated Gene DAPK1 in a Novel IFN-induced Growth Suppressive Pathway. Sanjit K. Roy, Hui Li, Shreeram C. Nallar and Dhan V. Kalvakolanu, Department of Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

PP5-180Recruitment of Stat1 to Chromatin is Required for Interferon-induced Serine Phosphorylation of Stat1 Transactivation Domain. Iwona Sadzak, Melanie Schiff, Edward Yang, Barbara Schaljo and Pavel Kovarik, Max F. Perutz, Laboratories, University of Vienna, Vienna, Austria, Laboratory of Molecular Cell Biology, Rockefeller University, New York NY.

PP5-181Role of Interferon-inducible Adenosine Deaminase that Acts on RNA 1 in the Inhibition of the Protein Kinase R Activation During HIV-1 Infection. Guerline Clerzius, Jean-François Gélinas, Aïcha Daher, Eliane Meurs, Anne Gatignol, Lady Davis Institute-Jewish General Hospital, McGill University, Montréal,Canada.

PP5-182Differential Involvement of IRF Members in IL-27 Synthesis Induced by TLR Ligation. Céline Molle, Véronique Flamand, Fabienne Willems, Michel Goldman and Stanislas Goriely, Institute for Medical Immunology (IMI), Université Libre de Bruxelles, Charleroi, Belgium.

PP5-183The Partial Rescue of Impaired Interferon-γ Signalling in Type I Interferon Receptor Defi cient Cells by Re-Expression of STAT1. Nicole L. Messina, Daniel J. Gough, Linda Hii, Ricky Johnstone, Chris Clarke, Peter MacCallum, Cancer Centre, St Andrews Place, East Melbourne, VIC Australia; Dept. Pathology, University of Melbourne, Parkville VIC Australia.

PP5-184The NFκB Regulator Bcl10 is a Novel Stat5 Target Gene. Zsuzsanna S. Nagy, Matthew J. LeBaron, Hallgeir Rui and Robert A. Kirken, Depart-ment of Biological Sciences, University of Texas at El Paso, El Paso, TX.

PP5-185IKK-related Kinases are Repressors of HIF-1 Transcriptional Activity. Simon-Pierre Gravel, Darren E. Richard, Marc J. Servant, Faculté de Pharmacie, Université de Montréal, Montréal, QC.

PP5-186Inductive and Suppressive Networks Regulate TLR9-dependent Gene Expression in vivo. Sven Klaschik, Debra Tross, Dennis M. Klinman, Laboratory of Experimental Immunology, National Cancer Institute, NIH, Frederick, MD.

PP5-187Glucocorticoid Regulation of the Type I Interferon-JAK/STAT Signaling Pathway. Jamie R. Flammer, Megan A. Kennedy, Yurii Chinenov, Lionel B. Ivashkiv and Inez Rogatsky, Graduate Program in Immunology and Microbial Pathogenesis, Weill Cornell Graduate School of Medical Sci-ences, New York, NY USA; Hospital for Special Surgery, New York, NY.

PP5-188Synergistic Up-regulation of Cytokine Encoding Genes by CpG Oli-gonucleotides Plus Poly (I:C). Lev Petrenko, Sven Klaschik, Hidekazu Shirota, and Dennis M. Klinman, Laboratory of Experimental Immunol-ogy, National Cancer Institute, NIH, Frederick, MD.

PP5-189Protein Kinase R-dependent Regulation of c-JUN and EGR-1 in Re-sponse to Double-stranded RNA. Arindam Chakrabarti, Robert H. Silver-man, and Bryan R. G. Williams, Department of Cancer Biology, Lerner Research Institute, The Cleveland Clinic, Cleveland, OH.

PP5-190IRF-1 is Required for Full NF-κB Transcriptional Activity at the HIV-1 LTR Enhancer. Marco Sgarbanti, Anna L. Remoli, Giulia Marsili, Edvige Perrotti, Roberto Orsatti, Ramona Ilari, Emilia Stellacci, Barbara Ridolfi , Alessandra Borsetti, Leonardo Sernicola, Barbara Ensoli, and Angela Battistini, Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Rome, Italy.

PP5-191Differential Regulation of the OASL and OAS1 Genes in Response to Viral Infection. Jesper Melchjorsen, Helle Kristiansen, Rune Christiansen, Johanna Rintahaka, Sampsa Matikainen, Søren R. Paludan and Rune Hartmann, Department of Molecular Biology, University of Aarhus, Denmark.

PP5-192Micro RNA Induction by Interferon alpha and their Potential Role to Interfere in the Negative Feedback Pathway. Fredy Siegrist and Ulrich Certa, RNAi Safety, F, Hoffmann-La Roche LTD, Basel, Switzerland.

PP5-193IFN Mediated Inactivation of the 4E-BP1 Repressor of mRNA Transla-tion Infl uences an Antiviral Response. Daniel Burke, Nahum Sonenberg, Leonidas C. Platanias, Eleanor N. Fish, Toronto General Research Inst. & University of Toronto, Toronto, ON.

PP5-194NADPH Oxidase Involvement in Regulation of Interleukin-8 mRNA Sta-bility in Lipopolysaccharide Treated Endothelial Cells. Imad Al Ghouleh, Alexandra Triantafi llopoulos, Sheldon Magder, McGill University, Critical Care Division, Royal Victoria Hospital, Montreal, QC.

PP 6 – CONTROL OF CELL GROWTH AND DEATH IN CANCER AND HEMATOPOIESIS

PP6-203GRIM-19: A Novel Cytokine-induced Tumor Suppressor. Dhan V. Kal-vakolanu, Sudhakar Kalakonda, Shreeram C. Nallar, Peng Sun, Depart-ment of Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

PP6-204Pre-operative Intracellular Peripheral Monocyte Glutathione Levels Correlate with Anti-tumor Immune-responses and Predict Overall Survival of Patients with Colorectal Carcinoma. Kazuko Uno, Tomohiko Matsuzaki, Katsumi Yagi, Junji Hamuro, Kiyotaka Okuno, Louis Pasteur Center for Medical Research, Kyoto, Japan.

PP6-205Interleukin-7 Controls Glucose Uptake in T-lymphocytes by Regulating Hexokinse II Gene Expression. Mounir Chehtane and Annette R. Khaled, Biomolecular Science Center, Burnett School of Biomedical Sciences,


University of Central Florida, Orlando, FL.

PP6-206The Role for Interferon Regulatory Factor-2 on Megakaryopoiesis Mediated by IFN-γ Induction. Atsuko Masumi, Isao Hamaguchi, Madoka Kuramitsu, Takuo Mizukami, Kazuya Takizawa, Haruka Momose, Seishir-ou Naito and Kazunari Yamaguchi, Department of Safety Research on Blood and Biological Products, National Institute of Infectious Diseases, Japan.

PP6-207Apoptosis Detection: A Novel Multiplex Assay for the Luminex® xMAP™ Platform. Mary M. Brodey, Wei Zheng, Jimin Wang, and Kevin Reagan, Invitrogen Corporation, Camarillo, CA.

PP6-208Targeting the Expression of GM2/GD2-synthase in Tumor Cell Lines Reduces Tumor Growth and Enhances Immune Responses. Rafael Fernandez-Botran, Shawn Greschel and David Roach, Department of Pathology & Laboratory Medicine, University of Louisville, Louisville, KY.

PP6-209Anti-proliferative Effect of Interferon-β in Mucosal and Cutaneous Hu-man Papilloma Virus (HPV)-transformed Keratinocytes. Chiantore M.V., Vannucchi S., Accardi R., Tommasino M., Affabris E., Fiorucci G. and Romeo G., Dept of Infectious, Parasitic and Immune-mediated Diseases, Istituto Superiore di Sanità, Rome, Italy; Dept of Experimental Medicine, Sapienza University of Rome, Rome, Italy.

PP6-210Regulation of NKG2D Ligand Expression by IL-10. Antonio E. Serrano, Marcela Gatica-Andrades, Evelyn Menares-Castillo, Macarena Garrido, Carolina Hernández, Mercedes N. López, Flavio Salazar-Onfray, Juan C. Aguillón and María C. Molina, Programme of Immunology, ICBM, Medi-cal Faculty, University of Chile, Santiago, Chile.

PP6-212Programmed Death-1 Pathway Inhibits γc common Cytokine Signal–driven T-cell Proliferation and Survival. Wei Huang, Andre Tanel, Francesco A Procopio, Simmone Fonseca, Bader Yassine-Diab, Julien van Grevenynghe, Chao Qiu, Denis Gaucher, Zhong He, Mohamed El Far, Yu Shi, Nicolas Chomont, Yuwei Zhang, Elias A Said, Labora-toire d’Immunologie, Centre de Recherche du Centre Hospitalier de l’Université de Montréal (CR-CHUM), Montréal, Canada.

PP6-213Cell Cycle and Translational Requirements for VSV oncolysis in Primary CD4+ T-Lymphocytes. Stephanie Oliere, Vanessa Tumilasci, David Stojdl, Nahum Sonenberg, John Bell and John Hiscott, Molecular Oncology Group, Lady Davis Institute - Jewish General Hospital and Depts. of Microbiology and Medicine, McGill University, Montreal, QC.

PP6-214Differential Biological Activities of E. Coli Produced Murine Interferon-α Proteins on B16-F10 Cells. Doranelly H Koltchev, Michael Skawinski, Karlene Moolchan, Lara Izotova, Sara Crisafulli, Xiao-Hong Lin, Steven Carbone, Thomas Lavoie, Ronald Jubin, William Clark and Sidney Pestka, PBL InterferonSource, Piscataway, NJ.

PP6-215Ecto-ATPase Expression Modulates the in vivo Rat Glioma Infl ammatory Response and Promotes Tumor Growth. Elizandra Braganhol, Fernanda B. Morrone, Andressa Bernardi, Màrcia R. Wink, Daiane Huppes, L, Biochemistry Department - UFRGS- ICBS - Porto Alegre, Brazil.

PP6-216STAT2 Contributes to Infl ammation-induced Colorectal Cancer. Ana M. Gamero, Anthony J. Scarzello, Matthew R.Young, Roycelynn Mentor-Marcel, Gerd Bobe, Jennifer Wise, and Nancy H. Colburn, Department of Biochemistry, Temple University School of Medicine, Philadelphia


PA, Laboratory of Experimental Immunology, Cancer and Infl ammation Program, NCI - Frederick, MD.

PP 7 – STRUCTURE AND FUNCTION OF CYTOKINES AND THEIR RECEPTORS

PP7-225Biological Activities and Detection of Cynomolgus Interferon-α Sub-types. Doranelly H. Koltchev, Michael Skawinski, Diane Vy, Xiao-Hong Lin, Sara Crisafulli, Karlene Moolchan, Lara Izotova, Edward Dolphin, Thomas B. Lavoie, William Clark, Ronald G. Jubin and Sidney Pestka, PBL InterferonSource, Piscataway, NJ, USA.

PP7-226Multiple Roles for the SOCS Box. Julie Piessevaux, Delphine Lavens, Frank Peelman and Jan Tavernier, Department of Medical Protein Research, VIB, Department of Biochemistry, Faculty of Medicine and Health Sciences, Ghent University, A. Baertsoenkaai 3, 9000 Ghent, Belgium.

PP7-227Design of High Affi nity interleukin-6 and gp130 Variants: Implications for Cytokine-receptor Assembly. Nina Adam, Stephanie Tenhumberg, Georg H. Waetzig, Athena Chalaris, Björn Rabe, Jan Suthaus, Dirk Seegert, Jürgen Scheller, Stefan Rose-John and Joachim Grötzinger, Institute of Biochemistry, Christian-Albrechts-University Kiel, Kiel, Ger-many, CONARIS Research Institute AG, Kiel, Germany.

PP7-228Erythropoietin and Glucocorticoids Exert Antagonistic Effects on STAT-5 Phosphorylation in Primary Human Erythroblasts. Emilia Stellacci, An-tonella Di Noia, Katija Jelicic, Maria Zingariello, Angela Di Baldassarre, Giovanni Migliaccio, Ronald Hoffman, Angela Battistini and Anna Rita Migliaccio, Departments of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore Sanità, Rome, Italy.

PP7-229Does S100A12 Activate Mast Cells and Monocytes/Macrophages Via Rage? Jesse Goyette, Weixing Yan, Su Yin Lim, Nick Di Girolamo and Carolyn L. Geczy, Centre for Infection and Infl ammation Research, School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.

PP7-230The Exon 3-encoded Domain of IL-15Ralpha Contributes to IL-15 High-affi nity Binding and is Crucial for IL-15 Antagonistic Effect of Soluble IL-15Ralpha. G. Bouchaud, L. Garrigue-Antar, V. Solé, A. Quéméner, Y. Boublik, E. Mortier, H. Perdreau, Y. Jacques and A. Plet, INSERM, U892, Centre de Recherche en Cancérologie Nantes/Angers, Groupe Cytokines et Récepteurs, Nantes, France; Université de Nantes, IFR26, Nantes, France.

PP7-231Structure Basis for the Molecular Recognition Between IL-15 and its Private Receptor IL-15Ralpha. Mami Chirifu, Chiharu Hayashi, Teruya Nakamura, Sachiko Toma, Tsuyoshi Shuto, Hirofumi Kai, Yuriko Yamaga-ta, Simon J. Davis and Shinji Ikemizu, Graduate School of Pharmaceuti-cal Sciences, Kumamoto University, Kumamoto, Japan.

PP7-232Dimerization of HVEM and BTLA in Cellular Membranes. Timothy C. Cheung, Matthew G. Macauley, Lisa M. Oborne, and Carl F. Ware, Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA.

PP7-233The type I Interferon System of Atlantic Salmon. Veronica Bergan and Børre Robertsen, Department of Marine Biotechnology. University of Tromsø, Norwegian College of Fishery Science, Tromsø, Norway.



PP7-234Fine Tuning of Receptor-selectivity for TNF Using a Phage Display System with One-step Competitive-subtractive Panning. Yasuhiro Abe, Hiroko Shibata, Tetsuya Nomura, Hiroyuki Kayamuro, Yohei Mukai, Tomoaki Yoshikawa, Yasuo Yoshioka, Madoka Taniai, Tsunetaka Ohta, Shinsaku Nakagawa, Haruhiko Kamada, Shin-ichi Tsunoda, Yasuo Tsut-sumi, National Institute of Biomedical Innovation (NiBio), Osaka, Japan.

PP7-235Structure-function Relationship of TNF Based on 3D Structural Analysis of Fully Active TNFR1-selective TNF Mutant. Yohei Mukai, Hiroko Shi-bata, Teruya Nakamura, Yasuo Yoshioka, Yasuhiro Abe, Tetsuya Nomura, Madoka Taniai, Tsunetaka Ohta, Shinji Ikemizu, Shinsaku Nakagawa, Shin-ichi Tsunoda, Haruhiko Kamada, Yuriko Yamagata, Yasuo Tsutsumi, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan; Laboratory of Pharmaceutical Proteomics Project, National Institute of Biomedical Innovation (NiBio), Osaka, Japan.

PP 8 – PATHOGEN EVASION OF THE HOST CYTOKINE RESPONSE

PP8-244HIV-1 Antagonizes Innate Antiviral Signaling Pathways by Targeting In-terferon Regulatory Factor-3 (IRF-3). Brian Doehle and Michael Gale Jr., Department of Immunology, University of Washington, Seattle, WA USA.

PP8-245Expression of H5N1 Non-Structural Protein 1 Alters Type I IFN Signal-ing. Danlin Jia1, Eleanor N. Fish1,2, 1Department of Immunology, Univer-sity of Toronto, Canada. 2Division of Cellular and Molecular Biology, Toronto General Research Institute, Canada.

PP8-246Gingival Epithelial Cells Reduce C. Albican Pathogenesis Through Cytokine Production. M. Rouabhia, Groupe de Recherche en Écologie Buccale, Faculté de Médecine Dentaire, Université Laval, QC.

PP8-247A Vaccinia Virus Deletion Mutant Reveals Additional Inhibitors of NFκB. Katharine Fagan, Brianne Couturier, Nick van Buuren, Crystal Harmon, Joanna Shisler and Michele Barry, Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB.

PP8-249Leishmania Promastigotes Modulate Macrophage Signal Transduction by Targeting Host Protein Tyrosine Phosphatases in a GP63-dependent Manner. Maria Adelaida Gomez, Irazu Contreras, Laleh Alisaraie, Max-ime Halle, Michel L. Tremblay, Albert M. Berghuis, Robert W. McMaster and Martin Olivier, Department of Microbiology and Immunology, McGill University, Montreal, QC.

PP8-250A Role for CCR5 in Dissemination of Vaccinia Virus in vivo. Ramtin Rahbar, Thomas T. Murooka & Eleanor N. Fish, Toronto General Research Institute, University Health Network and Department of Immunology, University of Toronto, Toronto, ON.

PP8-251Roles of IFN and Rnase L in the Inhibition of the Human Retrovirus, XMRV. Beihua Dong, Malathi Krishnamurthy, Ao Zhang, and Robert H. Silverman, Dept. of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH.

PP8-252Hepatitis C Virus Impairs Cytokine Production by Immune Cells. Marie-Eve Bilodeau, Emmanuel Moreau, Esther Tarrab and Alain Lamarre, Immunovirology Laboratory, INRS-Institut Armand-Frappier, Laval, QC.

PP8-253Hepatitis C Virus NS3/4A Protein Downregulates Toll-like Receptor 7 Signalling Pathway. Maarit Sillanpää, Pasi Kaukinen and Ilkka

Julkunen, Department of Viral Diseases and Immunology, National Public Health Institute, Mannerheimintie 166, FIN-00300 Helsinki, Finland.

PP8-254Tula and Puumala Hantavirus NSs ORFs are Functional and the Products Inhibit Activation of the Interferon-beta Promoter. Kirsi M. Jääskeläinen, Pasi Kaukinen, Ekaterina S. Minskaya, Angelina Plyusnina, Olli Vapalahti, Åke Lundkvist, Richard M. Elliott, Friedemann Weber, Antti Vaheri, and Alexander Plyusnin, Department of Virology, Haartman Institute, Univer-sity of Helsinki, Helsinki, Finland.

PP8-255Echinococcus Granulosus Escape the TH1 Protective Response. Manel Amri, Dalila Mezioug, Samia Bouaziz and Chafi a Touil-Boukoffa, Team: Cytokines and NOSynthase, Laboratory of Cellular and Molecular Biol-ogy, Faculty of Biological Science, USTHB, Algiers, Algeria.

PP8-256The Role of Type I Interferon in Legionella Infection of Murine and Hu-man Macrophages. Courtney R. Plumlee, Christian Schindler, Depart-ment of Microbiology, Columbia University, New York, NY.

PP8-257The R1 Subunit of Herpes Simplex Virus Type 2 Ribonucleotide Reductase Protects Cells Against TNF-alpha and Double-Stranded-RNA-induced Apoptosis by Direct Interaction with Procaspase-8. Florent Dufour, A. Marie-Josée Sasseville, Stéphane Chabaud, Richard M Siegel, Bernard Massie and Yves Langelier, Centre de recherche du Centre hospitalier de l’Université de Montréal and Institut du cancer de Montréal, Hôpital Notre-Dame, Montreal, QC.

PP8-258Vaccinia Virus Protein E3L Inhibits Type I Interferon Induction by the Cytoplasmic Signaling Pathway. Eugene Friedman, Isabelle J. Marié and David E. Levy, Department of Pathology and NYU Cancer Institute, Molecular Oncology and Immunology Program, New York University School of Medicine, New York, NY.

PP8-259Antagonism of the Innate Immune Response by Human Rhinovirus 1a. Jennifer Drahos and Vincent Racaniello, Department of Microbiology, Columbia University, New York, NY, Department of Microbiology, Columbia University College of Physicians & Surgeons, 701 W. 168th Street, New York, NY.

PP8-260Type I IFN and ISG Expression in Primary Hepatocytes Following dsRNA Stimulation and Expression Disruption by HCV Protease NS3/4A. Loubna Jouan, Pierre Melançon, Ian Gaël Rodrigue-Gervais, Valerie-Ann Raymond, Subajini Selliah, Marc Bilodeau, Rafi ck-Pierre Sékaly, Nathalie Grandvaux and Daniel Lamarre, Laboratoire d’immunologie virale, Département de Sciences Biomédicales, Université de Montréal, QC.

PP8-261Activation of TLR-independent Signaling Pathway by HIV-1 in Primary Human Macrophages. Mayra Solis, Thibault Mesplede, Peyman Nakhaei and John Hiscott, Lady Davis Insitute for Medical Research, and Depart-ments of Microbiology & Immunology and Medicine, McGill University, Montreal, QC.

19:30 EVENING AT THE MONTREAL MUSEUM OF FINE ARTS


Wednesday, October 15, 2008


CYTOKINES AND EMERGING INFECTIOUS PATHOGENS

Chairpersons: Eleanor Fish, University Health Network (Canada) Adolfo Garcia-Sastre, Mount Sinai School of Medicine (USA)

08:30 PL3-14 H5N1 and Interferons-α/ß: A Battle for Supremacy. Danlin Jia, Jae K. Yoo, Daniel Burke, John Nicholls, Eleanor N. Fish, Toronto General Research Institute, University Health Network & Department of Immunology, University of Toronto, Toronto, ON.

09:00 PL3-15 Modulation of Infl uenza Virus Replication and Virulence by Viral-host Protein Interactions. Adolfo García-Sastre, Department of Microbiology, Mount Sinai School of Medicine, New York, NY.

09:30 PL3-16 Ebola and Marburg Viruses: Immunopathology and Immunoprotection. Heinz Feldmann, Laboratory of Virology, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, MT.

10:00 PL3-17 Poxvirus Immune Evasion and Host Tropism are Linked by Cytokines. Grant McFadden, Dept. Molecular Genetics and Microbiology University of Florida, Gainesville, FL.


11:00 PL3-18 Viral and Host Control of Innate Immune Defenses in Hepatitis C Virus Infection. Michael Gale Jr. and the Gale Laboratory, Department of Immunology, University of Washington, Seattle WA.

11:30 PL3-19 Activation and Inhibition of Interferon and Cytokine Signaling by Emerging Pathogens. Curt M. Horvath, Evanston Northwestern Healthcare, Northwestern University, Evanston, IL.

12:00 PL3-27 Severe SARS Coronavirus Infection in Aged Macaques is Associated with Reduced Expression of Anti-Infl ammatory Type-1 Interferons. Bart L. Haagmans, Saskia L. Smits, Anna de Lang, Judith M.A. van den Brand, Lonneke M.E. Leijten, Arno Andeweg, Geert van Amerongen, Thijs Kuiken, and Albert D.M.E. Osterhaus, Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands.

12:15 PL3-236 SARS-Coronavirus Inhibits Interferon Induction both at Pre and Post-transcriptional Levels. Thomas Kuri, Xiaonan Zhang, Luis Martinez-Sobrido, Adolfo García-Sastre, Zhenghong Yuan, Friedemann Weber, Department of Virology, University of Freiburg, Freiburg, Germany.


12:30 – 14:00 ICS General Membership Meeting – MARQUETTE

12:30 – 14:00 ISICR General Membership Meeting – JOLLIET



WORKSHOP 9 JOLLIETCYTOKINES IN THE DEVELOPMENT OF INNATE AND ADAPTIVE IMMUNITY

Chairpersons: Ana Gamero, Temple University (USA) Simon Jones, Cardiff University (UK)

14:00 WO9-262 Development and Maintenance of T-cells Require Post- Translational Regulation of Anti-apoptotic MCL-1 and Pro- apoptotic BIM by IL-7. Wenqing Li, Tad Guszczynski, Julie Hixon, and Scott K. Durum, Laboratory of Molecular Immunoregulation, Cancer and Infl ammation Program, CCR, National Cancer Institute. NIH, Frederick, MD.

14:15 WO9-263 Interferon Regulatory Factor-1 Eradicates Tumors by Inducing Immune Responses Through T-cell Stimulation and Regulatory T-cell Inhibition. Katjana Klages, Antje Ksienzyk, Hansjörg Hauser, and Andrea Kröger, Department of Gene Regulation and Differentiation, Helmholtz Centre for Infection Research, Braun- schweig, Germany.

14:30 WO9-264 The Infl ammatory Traffi cking of Monocytic Cells in IL-6-defi cient Mice Highlights the Emergence of a CD11c+ Monocytic Popula- tion. Victoria J Hammond, Vincent Dioszeghy, Chantal Colmont, Emily Hams, Gareth W Jones, Nicholas Topley, Valerie O’Donnell, Philip R Taylor, Simon A Jones, Medical Biochemistry and Immunology, Cardiff University, Cardiff, UK.

14:45 WO9-278 Lymphotoxin-beta Receptor Signaling in the Intestine is Critical for Recruitment of Dendtric Cells that Contribute to IGA Class Switch Recombination. Douglas McCarthy, Leslie Summers deLuca, Lesley Ward, Hang Shi and Jennifer Gommerman, University of Toronto Department of Immunology, Toronto, ON. ICS Outstanding Scholar Award

15:00 WO9-266 The Interferon Sensitivity of Tick-borne Encephalitis Virus is Partially Mediated by Double-stranded RNA-dependent Protein Kinase. Anna K Överby, Friedemann Weber, Department of Virology, University of Freiburg, Freiburg, Germany.

15:15 WO9-269 Coordinated Expression of IFN-λ1 and IL-4, a Novel Feedback Loop Leading to the Reduction of Th2 Responses. G. Gallagher, GE. Gallagher, J. Dai & N. Megjugorac, Humigen-Genetic Immunology Laboratory. Hamilton, NJ.

15:30 WO9-267 Interferon-λ Contributes to Innate Immunity of Mice Against Infl uenza A Virus but not Against Hepatotropic Viruses. Markus Mordstein, Georg Kochs, Laure Dumoutier, Jean-Christophe Renauld, Søren R. Paludan, Kevin Klucher, and Peter Staeheli, Department of Virology, University of Freiburg, Freiburg, Germany.

15:45 WO9-268 A Role for Intra-cellular Interleukin-1alpha in Antiviral Defense. Ariel Werman, Ben Alkahe, Charles A. Dinarello and Menachem Rubinstein, Dept. of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.


WORKSHOP 10 MARQUETTEINDUCTION OF CYTOKINES AND INTERFERONS

Chairpersons: Takashi Fujita, Osaka University (Japan) Otto Haller, University of Freiburg (Germany)

14:00 WO10-289 NOX2: A Novel Regulator of Pro-infl ammatory Cytokine Production in Response to Respiratory Virus Infections. Nathalie Grandvaux, Karin Fink, Alexis Martel, Anton Soucy-Faulkner and Annick Duval, CRCHUM and Department of Biochemistry, Université de Montréal, Montréal, QC.

14:15 WO10-290 Defi ning the Pathogen Associated Molecular Patterns (PAMPs) of RNA Viruses and Their Recognition by RIG-I to Mediate Innate Immune Defenses. Takeshi Saito, David Owen, Fuguo Jiang, Joseph Marcotrigiano, and Michael Gale Jr., Department of Immunology, University of Washington School of Medicine, Seattle, WA. ISICR Young Investigator Award

14:30 WO10-291 Polo-like Kinase 1 (PLK1) and Protein Kinase IKK Epsilon – Two Markers of Cancer – Down-regulate IFN Induction by MAVS. Damien Vitour, Stéphanie Dabo, Malek Ahmadi Pour, Myriam Vilasco, Pierre-Olivier Vidalain, Yves Jacob, Pascal Pineau, Frédéric Tangy, John Hiscott and Eliane F. Meurs, Unit of Hepaci- virus and Innate Immunity, Pasteur Institute, Paris, France.

14:45 WO10-292 p53 Transcriptionally Activates IRF9 to Enhance Antiviral Immunity. César Muñoz-Fontela, Salvador Macip, Luis Martínez- Sobrido, Rana Elkholi, Lauren Brown, Joseph Ashour, Adolfo García-Sastre, Sam W. Lee and Stuart A. Aaronson, Department of Oncological Sciences, Mount Sinai School of Medicine, New York, NY. ISICR Young Investigator Award

15:00 WO10-293 IFN-gamma 3’untranslated Region AU-RICH Element-deleted Mice have Altered Immune Structure and Function. Deborah L. Hodge, Cyril Berthet, Jeff Subleski, William Bere, Xin Chen, Vincenzo Coppola, Matthew Buschman, Thomas Wolfe, Isabelle Shuggi, Howard A. Young, Laboratory of Experimental Immunol- ogy, Center for Cancer Research, National Cancer Institute- Frederick, Frederick, MD.

15:15 WO10-294 Viral Targeting of Human DEAD-box Protein 3 Reveals its Novel Role in IRF3/7 Activation. Martina Schröder, Marcin Baran and Andrew G. Bowie, School of Biochemistry and Immunology, Trinity College Dublin, Ireland. ICS Post-Doctoral Investigator Award

15:30 WO10-295 Membrane Fusion Activates Interferon Regulatory Factor 3. Ryan Noyce, Kathryne Taylor, and Karen Mossman, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON.

15:45 WO10-298 Receptor and Cell-specifi c Function of MAP3K8/TPL2 in Innate Immune Signaling and Cytokine Production. Lisa A Mielke, Karen Elkins, Robyn Starr, Douglas J Hilton, Philip Tsichlis, John J O’Shea, Wendy T Watford, Molecular Immunology and Infl ammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD. ICS Outstanding Scholar Award



WORKSHOP 11 DULUTHCYTOKINES IN PRECLINICAL MODELS OF CANCER AND INFECTIOUS DISEASE

Chairpersons: Howard Young, NCI-Frederick (USA) Allan Lau, University of Hong Kong (China)

14:00 WO11-321 IL-11 Dependent Gastric Tumourigenesis in GP130 Receptor Mutant Mice. Tracy L. Putoczki, Andrew G. Jarnicki, Therése Lundgren-May, Brent S. Mckenzie, Brendan Jenkins, Matthias Ernst, Ludwig Institute for Cancer Research, Melbourne, Victoria, Australia.

14:15 WO11-322 Chemical Targeting of the Innate Antiviral Response by Histone Deacetylase Inhibitors Renders Refractory Cancers Sensitive to Viral Oncolysis. Thi Lien-Anh Nguyên, Hesham Abdelbary, Meztli Arguello, Simon Leveille, John C. Bell and John Hiscott, Lady Davis Institute - Jewish General Hospital and Dept. of Microbiology & Immunology, McGill University, Montreal, QC.

14:30 WO11-323 Microbial Interactions in AIDS Pathogenesis: HIV-TAT Suppres- sion of Endotoxin-TLR4 Induced Interferon Induction and Cytokine Dysregulation. Howard CH Yim, James CB Li, Davy CW Lee, Allan S Lau, Cytokine Biology Group, Department of Paedi- atrics and Adolescent Medicine, and Bio-Screening Unit, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China.

14:45 WO11-324 IL-27 is a Novel Anti-viral Cytokine that Inhibits Replication of HIV-1 and HCV. Terrence W. Brann, Jun Yang, Da-Wei Huang, Astrid Frank, Richard A. Lempicki, Michael W. Baseler, Shaym Kottilili, H. Clifford Lane, and Tom Imamichi, Laboratory of Human Retrovirology, NCI-Frederick, Frederick, MD.

15:00 WO4-51 Intranasal Administration of Interferon-alpha Reduces Infl uenza A Morbidity in Ferrets. Daniela Kugel, Georg Kochs, Joachim Roth, Darwyn Kobasa, Michael Gray, Otto Haller, Peter Staeheli, and Veronika von Messling, Institute Armand-Frappier, University of Quebec, Montreal, QC.

15:15 WO11-325 IFNα Induces Long-lasting Refractoriness of JAK-STAT Signal- ing in the Mouse Liver Through Induction of the Negative Regulator USP18/UBP43. Magdalena Sarasin-Filipowicz, Xueya Wang, Ming Yan, Francois H.T. Duong, Valeria Poli, Douglas J. Hilton, Dong-Er Zhang, Markus H. Heim, Hepatology Laboratory, Department of Biomedicine, University Hospital Basel, Basel, Switzerland.

15:30 WO11-326 Combined Intra-tumoural Regulatory T-cell Depletion and Trans- forming Growth Factor-β Neutralisation Induces Regression of Established AE17 Murine Mesothelioma Rumours. Haydn T Kissick, Demelza J Ireland, Manfred W Beilharz, Discipline of Microbiology & Immunology, School of Biomedical, Biomolecular and Chemical Sciences, University of Western Australia, Crawley, Australia.

15:45 WO11-327 Immunotherapy with CpG Oligonucleotides and Antibodies to TNFα Rescue Neonatal Mice from Lethal Arena Virus-induced Meningoencephalitis. João A. Pedras-Vasconcelos, Montserrat Puig, Christian Sauder, Candie Wolbert, Mikhail Ovanesov and Daniela Verthelyi, Division of Therapeutic proteins-CDER- FDA, Bethesda, MD.


16:00 WO11-328 Generation of Interleukin-6 Receptor-defi cient Mice and Effect on Ovarian Cancer Progression. Molly M. McFarland, Holly F. Funk, Sara Kozma, Mingfu Zhou, Angela F. Drew, Department of Cancer and Cell Biology, University of Cincinnati, Cincinnati, OH.


WORKSHOP 12 LE GRAND SALONSIGNAL TRANSDUCTION II

Chairpersons: George Stark, Cleveland Clinic (USA) John Schrader, University of British Columbia (Canada)

14:00 WO12-346 Promoter Insertion Reveals Lysine Demethylase FBXL11 as a Negative Regulator of NFκB. Tao Lu*, Mark W. Jackson, Aatur D. Singhi, Eugene Kandel, Benlian Wang, Maojing Yang, Yi Zhang, Mark Chance, Masaru Miyagi, Andrei V. Gudkov, and George R. Stark, Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH. ISICR Young Investigator Award (also PP12-346)

14:30 WO12-350 Defi ning the Biology of IPS-1 in Innate Immunity. Yueh-Ming Loo and Michael Gale Jr., Department of Immunology, University of Washington School of Medicine, Seattle, WA. ISICR Christina Fleischmann Award

14:45 WO12-347 Regulation of Innate Immune Responses by DAI (DLM-1 / ZBP1) and Other DNA-sensing Molecules. ZhiChao Wang, Hideyuki Yanai, Myoung Kwon Choi, Tatsuma Ban, Tomohiko Tamura, Akinori Takaoka, Kazuko Nishikura, and Tadatsugu Taniguchi, Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo, Japan. ICS Outstanding Scholar Award

15:00 WO12-348 Role of the Protein Kinase TBK1 in TNFα-induced Apoptosis. Mireille Delhase, Takashi Yagi, Koichi S. Kobayashi and Makoto Nakanishi, Department of Immunology and AIDS, Dana Farber Cancer Institute and Department of Pathology, Harvard Medical School, Boston, MA.

15:15 WO12-360 Cross-regulation of Cytokine Signalling: Pro-infl ammatory Cytokines Restrict IL-6 Signalling Through Receptor Inter- nalisation and Degradation. Simone Radtke, Xiang-ping Yang, Stefan Wüller, Matthias Gaestel, Peter C. Heinrich, Fred Schaper and Heike M. Hermanns, Department of Biochemistry, Medical School RWTH Aachen, DFG Research Center for Experimental Biomedicine, Würzburg, Germany. ICS Young Investigator Award

15:30 WO12-351 Differential Requirement of MALT1 for BAFF-induced Outcomes in B Cell Subsets. Michael W. Tusche, Lesley A. Ward, Frances Vu, Doug McCarthy, Miguel Quintela-Fandino, Tak W. Mak and Jennifer L. Gommerman, Department of Immunology, Faculty of Medicine, University of Toronto, Toronto, ON.

15:45 WO12-352 Suppressor of Cytokine Signalling (SOCS)-5 Regulates IL-4 Activity Via Interaction with the IL-4 Receptor and Inhibition of JAK1 Kinase Activity. Tatiana Kolesnik, Ruth E. Columbus, Anjana Chakravorty, Tracy A. Willson, Naomi S. Sprigg, Wendy Carter, Jian-Guo Zhang, Nicos A. Nicola and Sandra E. Nichol- son, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.





CYTOKINE SIGNALING IN THE IMMUNE RESPONSE

Chairpersons: Christian Schindler, Columbia University (USA) Warren Leonard, NIH (USA)

16:30 SY5-18 Signaling and Gene Regulation by γc-Dependent Cytokines. Warren Leonard, Laboratory of Molecular Immunology, National Heart, Lung and Blood Institute, NIH, Bethesda, MD.

17:00 SY5-19 From Epithelial Innate to Adaptive Immune Response: Cross Talk Between Epithelial Cells and Dendritic Cells. Yong-Jun Liu, Department of Immunology, The University of Texas, M. D. Anderson Cancer Center, Houston, TX.

17:20 SY5-20 The TBK-1 Substrate DDX3X, a DEAD-box RNA Helicase, Provides Innate Immunity to Listeria Monocytogenes. Thomas Decker, Didier Soulat, Tilmann Bürckstümmer, Sandra Westermayer, Adriana Goncalves, Angela Bauch, Adrijana Stefanovic, Oliver Hantschel, Keiryn L. Bennett and Giulio Superti-Furga, Max F. Perutz Laboratories, University of Vienna, Vienna, Austria.

17:40 SY5-21 Cytokine Signals Regulate the Interface of Innate and Adaptive Immunity. Li Song, Courtney Plumlee, Carolyn Lee, John Seeley, Govind Bhagat, Ana Belen Blazquez, Cecilia Berin, Boris Reizis, and Christian Schindler, Departments of Microbiology, Medicine and Pathology, Columbia University, New York, NY.


REGULATORY T CELLS

Chairpersons: Ethan Shevach, Laboratory of Immunology, NIAID, NIH (USA) Ciro Piccirillo, McGill University (Canada)

16:30 SY6-22 Control of Immune Responses by Natural and Adaptive Regulatory T-cells. Ethan M. Shevach, Eva Huter, Dat Tran, and John Andersson, Laboratory of Immunology, NIAID, NIH, Bethesda, MD.

17:00 SY6-23 Human CD4+CD25high Natural Tregs and Th17 Effector Cells are Related. Clare Baecher-Allan, Gaëlle Beriou, Li Yang, William Hastings, David Anderson, Vijay K. Kuchroo and David A. Hafl er, Division of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA.

17:20 SY6-24 Thymic and Peripheral Regulatory T-cell Development. Chyi-Song Hsieh, Chan Wang Lio, Stephanie K. Lathrop, Jhoanne Bautista, Hyang Mi Lee, and Nicole San, Washington University, St. Louis, MO.

17:40 SY6-25 Adaptive Foxp3+ Regulatory T-cells. Maria A. C de Lafaille, Yi Ding, Juan J. Lafaille, Skirball Institute, New York University School of Medicine, New York, NY.



18:00 PD3-258 Vaccinia Virus Protein E3L Inhibits Type I Interferon Induction by the Cytoplasmic Signaling Pathway. Eugene Friedman, Isabelle J. Marié and David E. Levy, Department of Pathology and NYU Cancer Institute, New York University School of Medicine, New York, NY USA.

18:15 PD3-349 Investigation of the Mechanism of IRAK-2-mediated NFκB Activation Via Stimulation of TRAF6 Ubiquitination. Sinéad Flannery, Sinéad Keating and Andrew Bowie, School of Bio- chemistry and Immunology, Trinity College Dublin, Ireland. ICS Outstanding Scholar Award

18:30 PD3-355 Triad3A E3 Ligase Negatively Regulates the RIG-I/MAVS Signal- ing Pathway by Targeting TRAF3 for Degradation. Peyman Nakhaei, Thibault Mesplede, Qiang Sun, Mayra Solis, Long Yang, Rongtuan Lin, Tsung-Hsien Chuang, Carl F. Ware, John Hiscott, Lady Davis Institute, McGill University, Montreal, QC.

18:45 PD3-296 Role of Interferon Regulatory Factor 5 in Regulation of the Human Tumor Necrosis Factor Gene Expression. Thomas Krausgruber, Scott JP. Thomson, David G. Saliba, Irina A. Udalova, Kennedy Institute of Rheumatology, Imperial College London, London, UK.

POSTER SESSION 3 18:00 – 19:30 HOCHELAGA 2-6PP 9 – CYTOKINES IN THE DEVELOPMENT OF INNATE AND ADAPTIVE IMMUNITY

PP9-107Bioactive Chicken IL-12: Plant-derived Protein Production Platform Compatible with Veterinary Vaccine Applications. Giuliana Medrano, Nathan Stephans, David Radin, Maureen C. Dolan, and Carole L. Cramer, Arkansas Biosciences Institute, Arkansas State University, Jonesboro, AR.

PP9-265Early but not Late Interferon Alpha Therapy Against Hepatitis C Rescues Polyfunctional CD4+ and CD8+ Memory T-Cells. Mohamed S. Abdel-Hakeem, Nathalie Bédard, Gamal Badr, Mario Ostrowski, Julie Bruneau, Rafi ck P. Sékaly, Bernard Willems, Jenny E. Heathcote and Naglaa H. Shoukry, Centre de Recherche du Centre Hospitalier de l’Université de Montréal (CHUM), Hôpital St-Luc, Université de Montréal, Montréal, QC.

PP9-270Production of, and Response to, IFN-λ1 by Plasmacytoid Dendritic Cells. N. Megjugorac, GE. Gallagher, G. Gallagher, Humigen-Genetic Immunology Laboratory, Hamilton NJ.

PP9-271IFN-λ1 (IL-29) Suppresses the Differentiation of Human Naive and Memory Th2 Cells Without Inhibiting their Proliferation. J. Dai, N. Megjugorac, GE. Gallagher & G. Gallagher, Humigen-Genetic Immunology Laboratory, Hamilton, NJ.

PP9-272Antigen-independent Proliferation and Functional Differentiation of CD8 T Lymphocytes Stimulated by IL-6 in the Presence of IL-7 OR IL-15. Subburaj Ilangumaran, Julien Gagnon, Chantal Leblanc and Sheela Ramanathan, Immunology division, Department of Pediatrics, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC.

PP9-273Interleukin-12 Enhances the Fungicidal Activity of Neutrophils from Gerbils with Sporothrix Schenckii Infection. Aurelio Flores-García, Porfi rio López-Lugo, Pedro Aguiar-García, Nidia K. Castillón-Benavides, Omar J. Castillón-Benavides, José R. Altamirano-Gallegos, Rogelio Sánchez-Gutiérrez, Eloy A. Zepeda-Carrillo, Martha Barba-Barajas and Vicente Garibald, Unidad Académica de Medicina, Universidad Autónoma de Nayarit, Tepic, Nayarit, México.

PP9-274Identifi cation of Small RNAs Produced by Cleavage of Hepatitis C Viral RNA with RNase L that Bind RIG-I. Krishnamurthy Malathi, Michael Gale, and Robert H. Silverman, Dept. of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH.

PP9-275Interferon Subtype Stimulation of Dendritic Cells: Key Activators of Anti-viral Immunity. Cassandra M James, Seamus Duffy, Dean Pem-berton, Anthony Armson, Philip A Stumbles, School of Veterinary and Biomedical Sciences, Murdoch University, Perth, Western Australia, Australia.

PP9-276Annexin-1 Regulates Cytokines and Dexamethasone Sensitivity Via Glucocorticoid-induced Leucine Zipper. Yuan H. Yang, Daniel Aeberli, Michelle Leech, April Dacumos, Jin R. Xue and Eric F. Morand, Centre for Infl ammatory Diseases, Department of Medicine, Monash University, Clayton, Victoria, Australia.

PP9-277Mutant TNF Elicits Th2-type Responses for Enhanced Mucosal Immu-nity. Hiroyuki Kayamuro, Yasuo Yoshioka, Kazufumi Katayama, Haruhiko Kamada, Tetsuya Nomura, Yasuhiro Abe, Takachika Hiroi, Shin-ichi Tsunoda, Yasuo Tsutsumi, National Institute of Biomedical Innovation, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.

PP9-279Type I IFNs Affect Early Thymocyte Development. Dominique Gauchat, Marie-Laurence Baron, Ross La Motte-Mohs, Juan-Carlos Zúñiga-Pfl ücker, and Rafi ck-Pierre Sékaly, Laboratoire d’Immunologie, Centre de Recherches du CHUM, Hôpital Saint-Luc, Montréal, Qc., Canada; Département de Microbiologie et Immunologie, Faculté de Médecine, Université de Montréal, Montréal, Montréal, Qc., Canada; Unité INSERM U743, Immunologie humaine. Centre de Recherches du CHUM, Hôpital Saint-Luc, Montréal, QC.

PP9-280SGLT-1 as a Novel Immunological Player in the Intestinal Mucosa. Marco Palazzo, Silvia Gariboldi, Laura Zanobbio, Silvia Selleri, Giusep-pina F Dusio, Valentina Mauro, Anna Rossini, Andrea Balsari and Cristiano Rumio, MIL- Mucosal Immunity Laboratory, Department of Human Morphology, Università degli Studi di Milano, Milan, Italy.

PP9-281Low Molecular Weight Hyaluronic acid Increases the Self Defence of Skin Epithelium by Induction of β-defensin 2 via TLR2 and 4. Silvia Gariboldi, Marco Palazzo, Laura Zanobbio, Silvia Selleri, Michele Sommariva, Andrea Balsari, Cristiano Rumio, MIL – Mucosal Immunity Laboratory, Department of Human Morphology, Università degli Studi di Milano, Milan, Italy.

PP9-282Alpha-1-Antitrypsin is an Endogenous and Specifi c Inhibitor of Pro-infl ammatory Cytokine Production in Whole Blood. Gregory B. Pott, Edward D. Chan, Charles A. Dinarello, and Leland Shapiro, Denver Veterans Affairs Medical Center, National Jewish Medical and Research Center, Denver, CO.



PP9-283Alpha-1-Antitrypsin is an Inhibitor of Intracellular Pro-infl ammatory Cytokine Production in Monocytes and T-cells. Scott Beard, Gregory B. Pott, Kristin Morris, Brent Palmer, and Leland Shapiro, Denver Veterans Affairs Medical Center and University of Colorado Denver, Denver, CO.

PP9-284The Effect of IL-6 Overproduction in vivo on the Balance of Foxp3+ Regulatory T-cells and Th17 Cells. Minoru Fujimoto, Fumitaka Terabe, Satoshi Serada, Teppei Nishikawa, Yuko Matsukawa, Tomoharu Oh-kawara, Jiro Horino, Barry Ripley, Akihiro Kimura, Tadamitsu Kishimoto and Tetsuji Naka, Laboratory for Immune Signal, National Institute of Biomedical Innovation, Osaka University, Japan.

PP9-285TSLP as a Mediator of Crosstalk Between Bronchial Smooth Muscle and Mast Cells. Michael R. Comeau, Zoulfi a Allakhverdi, Heidi K. Jessup, and Guy Delespesse, Infl ammation Research, Amgen Inc, Seattle, WA.

PP9-286Modulation of Humoral and Cellular Immune Responses Generated Against Hepatitis C Vrus Core DNA Vaccine by Utilizing Granulocyte Monocyte-Colony Stimulating Factor and Interleukin-23 as Immunologi-cal Adjuvants. Christine Hartoonian, Massoumeh Ebtekar, Ali Karami, Mehdi Mahdavi, Kayhan Azadmanesh, Mehdi Yousefi pour, Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran Univer-sity of Medical Sciences, Tehran, Iran.

PP9-287ACT1 is Required for IL-25-dependent TH2 Responses. Shadi Swaidani, Katarzyna Bulek, Zizhen Kang, Caini Liu, Yi Lu, Mark Aronica, Xiaoxia Li, Department of Immunology, Cleveland Clinic, Cleveland, Ohio.

PP9-288Chimeric Fusokines Borne of the Marriage of the TGFβ Receptor II Ectodomain and Pro-infl ammatory Cytokines IL2 and GMCSF for Breast Cancer Immunotherapy. Claudia A. Penafuerte-Diaz, Norma Bautista-Lopez and Jacques Galipeau, MCETC, McGill University, Montreal Canada.

PP 10 – INDUCTION OF CYTOKINES AND INTERFERONS

PP10-296Role of Interferon Regulatory Factor 5 in Regulation of the Human Tumor Necrosis Factor Gene Expression. Thomas Krausgruber, Scott JP. Thom-son, David G. Saliba, Irina A. Udalova, Kennedy Institute of Rheumatol-ogy, Imperial College London, London, United Kingdom.

PP10-297Regulation and Functional Characterisation of a Novel Interferon, IFNε. KaYee Fung, Helen Cumming, Shamith Samarajiwa, Shelley Smal-lacombe and Paul Hertzog, Centre for Innate Immunity and Infectious Disease, Monash University, Clayton, Victoria, Australia.

PP10-299Cytokine Response to Liposome-encapsulated Poly ICLC Prophylaxis of Infl uenza A Virus Infection. Mary E. Christopher, Nina E.C. Karpoff, Sathi-yanarayanan Viswanathan, Xiaojiang Dai, Glen J. Schnell, Jonathan P. Wong, Biotechnology Section, Defence R&D Canada – Suffi eld, Ralston, AB.

PP10-300TNF Production Induced by Staphylococcus Aureus Involves Different Signalization Pathways in Monocytes, Alveolar Macrophages and Peri-toneal Macrophages. Ronan Kapetanovic, Catherine Fitting, Jean-Marc Cavaillon, Minou Adib-Conquy, Institut Pasteur, Paris, France.

PP10-301ELISpot and Cytokine Levels are Markers of Cell Mediated Immunity. Geetanjali Gupta, Arif Azam Khan, D. N. Rao, India Institute of Medical Sciences, New Delhi, India.


PP10-302Examining the Role of Nuclear Factor Kappa-B Proteins in Human Cytokine Gene Expression: Comparison of Type I and Type III Interferons. Fui Goon Goh, Scott J.P. Thomson and Irina A. Udalova, Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College London, London, UK.

PP10-303Toll-like Receptor 4/MyD88 Pathway Mediates Microglial Proinfl amma-tory Cytokine Responses to Thrombin-associated Coagulation Protein Complexes. Jörg Scheffel, Denise van Rossum, Jonathan R. Weinstein, Hassan Dihazi, Tommy Regen, Wolfgang Brück, Helmut Kettenmann, Marco Prinz, Thomas Möller and Uwe-Karsten Hanisch, Institute of Neuropathology, University of Göttingen, Germany.

PP10-304Glatiramer Acetate Induces IL-1 Receptor Antagonist and Inhib-its the Induced Production of IL-1β in Human Monocytes. Danielle Burger, Nicolas Molnarfi , Martin S. Weber, Karim J. Brandt, Thomas Prod’homme, Lyssia Gruaz, Michel Choffl on, Scott S. Zamvil, Patrice H. Lalive, Division of Immunology and Allergy, Clinical Immunology Unit, University Hospital and Faculty of Medicine, University of Geneva, Switzerland.

PP10-305Dynamic Accumulation of Plasmacytoid Dendritic Cells in Lymph Nodes is Regulated by Type I IFN-beta. Yunfei Gao, Beata Majchrzak, Eleanor Fish and Jennifer L. Gommerman, Department of Immunology, University of Toronto, Toronto, ON.

PP10-306IFN-β Induces the Expression of Secreted IL-1 Receptor Antagonist in Human Monocytes Through a MEK2/PI3K-dependent, ERK1/2-inde-pendent Pathway. Karim J. Brandt, Nicolas Molnarfi , Lyssia Gruaz, and Danielle Burger, Division of Immunology and Allergy, Clinical Immunol-ogy Unit, University Hospital and Faculty of Medicine, University of Geneva, Switzerland.

PP10-307Is Nuclear Accumulation of Interferon Regulatory Factor (IRF)-3 Depen-dent on a Functional Nuclear Localization Sequence? Annie Bibeau-Poirier, Jean-François Clément, Rongtuan Lin, Marc J. Servant, Faculty of Pharmacy, University de Montreal, Montreal, QC.

PP10-308In vitro Effects on Cellular Metabolism and Cytopathic Expression of Vesicular Stomatitis Virus Strains. Valérie Janelle, Frédérick Brassard, Kathya Dupont, Alain Roy, Marc Desforges, Pierre Talbot, Alain Lamarre, Laurent Poliquin, Biomed Research Center and Department of Biology, Université du Québec à Montréal, Montreal, QC.

PP10-309Ad-huPA Effects on Transcription Factors T-BET/GATA3 in Bleomycin-induced Experimental Scleroderma. Francisco J. Gálvez-Gastelum, Ana L. Márquez-Aguirre, José Navarro-Partida, José M. Vera Cruz, Jaime González Cuevas, José Macías-Barragán, Jesús J. García-Bañuelos and Juan S. Armendáriz Boruda, Instituto de Biología Molecular en Medicina y Terapia Génica. CUCS. Universidad de Guadalajara, México.

PP10-310Lipopolysaccharide: A Potent Inhibitor of Interferon Induction. Christo-pher P. Malinoski, John M. Ngunjiri, Margaret J. Sekellick, and Philip I. Marcus, Dept. Molecular & Cell Biol., University of Connecticut, Storrs, CT.

PP10-311Molecular Networks in Innate Immunity. Tilmann Burckstummer, Evren Karayel, Evelyn Dixit, Adriana Goncalves, Gerhard Durnberger, Hannah Jahn, Melanie Planyavsky, Jacques Colinge, Keiryn L Bennett and Giulio



Superti-Furga, CeMM, Research Center for Molecular Medicine of the Austrian Academy of Sciences Vienna, Austria.

PP10-312Infl uenza A Virus Induces an Immediate Cytotoxic Effect by all Major Subsets of Peripheral Blood Mononuclear Cells. Monika Sachet, Sanda Sturlan, Suzann Baumann, Andreas Spittler and Michael Bergmann, Dept. of General Surgery, Medical University of Vienna, Vienna, Austria.

PP10-313Induction of IFN Responses in Infl uenza B Virus-infected Human Mono-cyte-derived Dendritic Cells. Pamela Österlund, Mari Strengell and Ilkka Julkunen, Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland.

PP10-314The Role of Type I and Type III Interferons in Salmonella-infected Dendritic Cells. Taija E. Pietilä, Pamela Österlund, and Ilkka Julkunen, Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland.

PP10-315Activation of Interferon Response in Human PBMC by Avian Infl uenza H5N1 Virus. Concetta Castilletti, Eleonora Lalle, Licia Bordi, Roberta Chiappini, Alessandra Sacchi, Maria Rosaria Capobianchi, Laboratory of Virology, National Institute for Infectious Diseases “Lazzaro Spallan-zani”, Rome, Italy.

PP10-316TOLLOME: A Web Based Knowledge Discovery Environment for Innate Immunity. Shamith Samarajiwa, Sam Forster, Katie Auchettl, Sarah Boyd, Paul Hertzog, Center for Innate Immunity and Infectious Diseases, Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia.

PP10-317DNA Damage Response Activates Interferon Signaling. Sabrina Brzostek, Chris Gordon, Sarah VanScoy, Nancy C. Reich, Department of Molecular Genetics & Microbiology, Stony Brook University, Stony Brook, NY.

PP10-318Identifi cation of TSLP-dependent Mediators in a Calcipotriol Mouse Model of Skin Infl ammation. Heidi K. Jessup and Michael R. Comeau, Infl ammation Research, Amgen, Inc. Seattle, WA.

PP10-319Upregulation of IL-15 Gene Expression in Human Monocytic Cells by HSV-1 is Mediated by TLR2 Signalling. R. Ahmad, S. El Bassam, P. Cor-deiro, J. Menezes, Ste-Justine Hospital Research Center and Depart-ment of Microbiology & Immunology, Faculty of Medicine, University of Montreal, Montreal, QC.

PP10-320Mechansim of PML-induced Senescence. Mathieu Vernier, Veronique Bourdeau, David Baudry, Gerardo Ferbeyre, Department of biochemis-try, University of Montreal, Montreal, QC.

PP 11 – CYTOKINES IN PRECLINICAL MODELS OF CANCER AND INFECTIOUS DISEASE

PP11-329CCL5 Promotes Breast Cancer Proliferation Through mTOR/4E-BP1 Dependent mRNA Translation. Thomas T. Murooka, Ramtin Rahbar and Eleanor N., Toronto General Research Inst. & University of Toronto, Toronto, Canada; McGill University, Montreal, Canada; Northwestern University School of Medicine, Chicago, USA.

PP11-330Prevention of Azoxymemethane/Dextran Sodium Sulfate-induced Colon Carcinogenesis by CCR2 Blockade. Naofumi Mukaida, Feodora I. Kosta-

dinova, and Boryana K. Popivanova, Division of Molecular Bioregulation, Cancer Research Institute, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-0934, Japan.

PP11-331Innate Immunity: Preclinical Study of Eradication of Tumor Cells by IFN-activated Monocytes in vitro and in vivo. Samuel Baron, Joyce Poast, Fujio Suzuki, and Makiko Kobayashi, Kathleen Clouse, Sylvia Bacot, Linda Tiffany, Carla Lankford, Gunther Boekhoudt, Angel Morrow, Samuel Fey, Hana Schmeisser, Joseph Bekisz, and Kathryn Zoon, University of Texas Medical Branch, Dept. of Microbiology and Immunology, Galveston, TX; University of Texas Medical Branch, Dept. of Internal Medicine, Galveston, TX; NIAID, NIH, Bethesda, MD.

PP11-332HIV Infection Leads to Increased Proliferation of T-cells by Two Distinct Pathways that Differentially Affect CD4 and CD8 T-cells. Christopher Wilhelm, Michele Di Mascio, Zonghui Hu, Sharat Srinivasula, Vishakha Thaker, Joseph Adelsberger, Adam Rupert, Michael Baseler, Yutaka Tagaya, Gregg Roby, Catherine Rehm, Dean Follmann, Clifford Lane and Marta Catalfamo, CMRS/Laboratory of Immunoregulation, NIAID, NIH, Bethesda, MD.

PP11-333Oral Type 1 Interferon Protection from Lethal Infl uenza Virus. Manfred W. Beilharz and Alayne L. Bennett, Discipline of Microbiology and Im-munology, School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, 35 Stirling Hwy, Crawley, Perth, Australia.

PP11-334Pattern of Regulatory T-cell Migration in AE17 Tumour Bearing Mice Following Tumour Challenge. Haydn T Kissick, Demelza J Ireland, Manfred W Beilharz, Discipline of Microbiology and Immunology, M310, School of Biomedical, Biomolecular and Chemical Sciences, The Univer-sity of Western Australia, Crawley, WA, Australia.

PP11-335Proteome Profi ling of Multiple Myeloma and the Associated Microen-vironment in Bone Marrow. Christopher Gerner, Astrid Slany, Thomas Mohr, Josef D. Schwarzmeier, Christoph Zielinski, Johannes Drach, Karl Landsteiner Institute for Cytokine Research, Vienna, Austria.

PP11-336IP-10 and IL-1Ra elevation in cytomegalovirus-infected vs normal midtrimester amniotic fl uids. Sharon S.W. Chow, Beverley Hall, Cheryl A. Jones, Maria E. Craig, Jacki Catteau, Andrew R. Lloyd, William D. Rawlinson, School of Medical Sciences, University of New South Wales; Virology Research, POWH & UNSW Research Laboratories, Prince of Wales Hospital; Department of Microbiology, SEALS, Prince of Wales Hospital.

PP11-337The TGF-β Superfamily Cytokine MIC-1 Causes Tumour-induced An-orexia/Cachexia by Modulating Appetite Control Centres in the Hypo-thalamus. Samuel N Breit, Heiko Johnen, Shu Lin, Tamara Kuffner, David A Brown, Vicky Wang-Wei Tsai, Asne R Bauskin, Liyun Wu, Eva Corey, Amanda Sainsbury, Herbert Herzog, Centre for Immunology, St Vincent’s Hospital and University of NSW, Australia.

PP11-338Studies on Interleukin-21 Production in HIV-infected/AIDS Patients: A Potentially New Biomarker for AIDS Progression. Alexandre Iannello, Cecile Tremblay, Jean-Pierre Routy, Mohamed-Rachid Boulassel, Emil Toma and Ali Ahmad, Laboratory of Innate Immunity, Ste-Justine Hospital Research Center; Department of Microbiology & Immunology, University of Montreal, Montreal, QC.


PP11-339Toll-like Receptor Mediated Innate Immune Response in Hepatocytes Suppressed Woodchuck Hepatitis Virus Replication Via Interferon-independent Pathway. Xiaoyong Zhang, Zhongji Meng, Yang Xu, Jörg Schlaak, Michael Roggendorf, Mengji Lu, Institute of Virology, University Hospital of Essen, Essen, Germany; Department of Microbiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

PP11-340Effects of Interferon-alpha on Regulatory T-cell Depletion in Cancer Immunotherapy. Shawna Wall, Duane Jeansonne, Pei-Yi Lin, Aijie Liu, Gaby Rennebeck, Suzanne Thibodeaux, Carolina Livi, Ben Daniel, Tyler Curiel, Department of Medicine, Cancer Therapy & Research Center at the University of Texas Health Science Center, San Antonio, TX.

PP11-341Cell-associated IL-15 is the Mediator of Tumor Immunity in B16ALPHA Vaccine Cells. Tzu G. Wu, Theresa K. Umhoefer, Jade Cao, Robert J. Burgmeier, Christine F. Grewe, Michael R. DeWall, Alexander T. Burton, Michael J. Gerger, Molly C. Schwab, and W. Robert Fleischmann, Jr., The University of Minnesota Medical School, Minneapolis, MN.

PP11-342The Impact of IFNα2β on Signaling of STAT1, STAT3, STAT5a, STAT5b, and SOCS3 in Clinical Melanoma Precursors, the Atypical NEVI. Wenjun Wang, Ling Chen, Arash Radfar, John M Kirkwood, Division of Hematology and Oncology, Department of Medicine, School of Medi-cine, University of Pittsburgh, Pittsburgh, PA.

PP11-343Effi cacy of Human Recombinant Interferon-α2b (VIFERON®) in Treat-ment of Neonatal Bacterial and Viral Infections. Marina V. Degtyareva, Irina G. Soldatova, Ekaterina G. Getya, Nikolay N. Volodin, Nina V. Var-tanian, Valentina V. Malinovskaya, Department of Neonatology, Russian State Medical University, Moscow, Russia.

PP11-344Down-regulation of CXCL-1 Inhibits Growth of Colorectal Liver Metas-tases. Obul R Bandapalli, Stephan M Goeppinger, Matthias Gaida, Moritz Wente, Peter Schirmacher and Karsten Brand, Institute of Pathology and Department of Surgery, University Clinic Heidelberg, University of Heidelberg, Im Neuenheimer Feld 220/1, D-69120 Heidelberg, Germany.

PP11-345Gentically Engineered Oncolytic Vesicular Stomatitis Virus to Stimulate Anti-tumor Immune Response. Simon Leveille and John Hiscott, Molecu-lar Oncology Group, Lady Davis Institute, McGill University, Montreal, QC.

PP 12 – SIGNAL TRANSDUCTION II

PP12-346Promoter Insertion Reveals Lysine Demethylase FBXL11 as a Negative Regulator of NFκB. Tao Lu*, Mark W. Jackson, Aatur D. Singhi, Eugene Kandel, Benlian Wang, Maojing Yang, Yi Zhang, Mark Chance, Masaru Miyagi, Andrei V. Gudkov, and George R. Stark, Department of Molecu-lar Genetics, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH.ISICR Young Investigator Award

PP12-353IL-17 Signaling Induces Sequential Phosphorylation of C/EBPβ. Fang Shen, Nan Li, Troy Wood, and Sarah L. Gaffen, Dept. of Oral Biology, Dept. of Chemistry, SUNY Buffalo, Buffalo NY.

PP12-354The Impact of Defective GP130-SHP2/SOCS3 Signaling on the Astro-cyte Response to Hyper-IL6. Ricardo F. Frausto, Gareth Denyer, Jürgen Scheller, Stefan Rose-John, Brendan J. Jenkins, Matthias Ernst, Iain L.

Campbell, School of Molecular and Microbial Biosciences, University of Sydney, Sydney, NSW, Australia

PP12-356Differential Actions of GP130 Cytokines: Mechanisms of Oncostatin M Functional Specifi city. Nick Underhill-Day and John K. Heath, College of Life and Environmental Sciences, School of Biosciences, University of Birmingham, Birmingham, UK.

PP12-357MGBP-2 Inhibits RAC Activation by Platelet-derived Growth Factor or Integrin Engagement: Possible Role of Phosphatidylinositol 3-kinase. Angela F. Messmer, Sujata Balasubramanian, and Deborah J. Vestal, Department of Biological Sciences, University of Toledo, Toledo, OH.

PP12-358Molecular Cloning and Functional Studies of Atlantic Salmon Mito-chondrial Antivrial Signaling Protein. Silje Lauksund, Tina Svingerud, Veronica Bergan, Øyvind Kileng and Børre Robertsen, Department of Marine Biotechnology, Norwegian College of Fishery Science, University of Tromsø, Norway.

PP12-359A Novel Mechanism for the Regulation of GAB1 Recruitment to the Plasma Membrane. René Eulenfeld, Fred Schaper, Department of Bio-chemistry, RWTH Aachen University, Aachen, Germany.

PP12-361Characterization of the Bovine Type I Interferon Locus. Angela Walker and R. Michael Roberts, Department of Veterinary Pathobiology, Univer-sity of Missouri, Columbia, MO.

PP12-362WNTS as a New Kind of Cytokines. Jing-pu Zhang, Bin Hong and Yuan Yang, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences.

PP12-363What do Cytokine Polymorphisms Tell Us About Human Population History? The Case of European Populations. Fabian A. Crespo, Rafael Fernandez-Botrán, Manuel F. Casanova, Rachel Oberst and Christopher R. Tillquist, Department of Pathology and Laboratory Medicine, Univer-sity of Louisville, Louisville, KY.

PP12-364Single Nucleotide Polymorphisms of TNFα Gene and its Receptors 1 and 2 in Mexican Lepromatous Leprosy Patients. Margarita Mon-toya-Buelna, José F. Muñoz-Valle, Anabell Alvarado-Navarro, Rocio I. López Roa, Luis E. Figuera-Villanueva, Mary Fafutis-Morris, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, México.

PP12-365Genomic Analysis of the Equine Type I Interferon Family. Eva Wattrang, Bettina Wagner and David A. Morrison, Department of Virology, Immunobiology and Parasitology, National Veterinary Institute, Uppsala, Sweden.

PP12-366The Production of Interferon-β Induced by HIV-1 Nef Treatment of Pri-mary Human Monocyte-derived Macrophages Requires the PI3K/AKT Pathway. Zulema A. Percario, Ilaria Gentile, Giorgio Mangino, Gianna Fiorucci, Giovanna Romeo, Elisabetta Affabris, Dept. of Biology, Univ. Roma Tre, Rome, Italy.

PP12-367Ubiquitin-regulated Recruitment of IKKε to MAVS Interferon Signal-ing Adapter. Suzanne Paz, Myriam Vilasco, Meztli Arguello, Qiang Sun, Judith Lacoste, Rongtuan Lin, Eliane F. Meurs, John Hiscott, Molecular Oncology Group, Lady Davis Institute - Jewish General Hospital, McGill University, Montreal, QC.



PP12-368Anti-Infl ammatory Effect of Citrus Grandis Osbeck (DANGYUJA) Leaves in LPS-stimulated raw 2764.7 Cells. Eun-Jin Yang, Gyeong-Jin Kang, Hye-Ja Lee, Sun-Soon Park, Weon-Jong Yoon, Hee-Kyoung Kang, So-Mi Kim and Eun-Sook Yoo, Department of Pharmacology, College of Medi-cine, Cheju National University, Jejudaehakno, Jeju, South Korea.

PP12-369NF-κB is Transported into the Nucleus Via A Subset of Importin α Molecules. Riku Fagerlund, Krister Melén, Xinmin Cao, Ilkka Julkunen, Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland.

PP12-370Cigarette Smoke Products Suppress Anti-viral Effects of Type I Inter-feron Via Phosphorylation-dependent Downregulation of its Receptor. Wei-Chun Huang Fu, Jianghuai Liu, Ronald N. Harty and Serge Y. Fuchs, Department of Animal Biology and Mari Lowe Center for Comparative Oncology, University of Pennsylvania, Philadelphia, PA.

PP12-371Virus-induced Unfolded Protein Response Attenuates Anti-viral Defenses Via Phosphorylation-dependent Ubiquitination and Degrada-tion of Type I Interferon Receptor. Jianghuai Liu, Wei-Chun Huang Fu, K.G. Suresh Kumar, James P. Casey, Robert Hamanaka, Christina Grigo-riadou, Rafael Aldabe, J. Alan Diehl, and Serge Y. Fuchs, Department of Animal Biology and Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, Univeristy of Pennsylvania, Philadelphia, PA.


PP12-372A Novel Function of STAT3 in Cellular Respiration. Joanna Wegrzyn, Ramesh Potla, Yong-Joon Chwae, Qifang Zhang, Marta Derecka, Karol Szczepanek, Magdalena Szelag, Agnieszka Gornicka, Akira Moh, Shadi Moghaddas, Qun Chen, Santha Bobbili, Xin-Yuan Fu, Edward J. Lesnefsky, Department of Immunology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland,OH.

PP12-373CK2 Positively Regulates Janus Kinase-signal Transducer and Activator of Transcription Signaling by Interactions with Janus Kinases. Ying Zheng, Hongwei Qin, Etty Benveniste, Department of Cell Biology, Uni-versity of Alabama, Birmingham, AL.

PP12-374Tick-borne Encephalitis Virus Proteins PRM and NS1 Act as Potent Inhibitors of Cytokine Gene Expression. Suvi Kuivanen, Pasi Kaukinen, Maarit Sillanpää, Nathalie Uzcátegui De Castillo, Antti Vaheri, Ilkka Julkunen and Olli Vapalahti, Department of Virology, Haartman Institute, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

20:30 DREAMSCAPE GALA – WINDSOR STATION


Thursday, October 16, 2008

KEYNOTE LECTURE

08:00 KEY-2 30 Years After the Dawn of Cytokine Molecular Biology: Roles of IRF Transcription Factors. Tadatsugu Taniguchi, Department of Immunology, University of Tokyo, Japan.


CYTOKINE-BASED THERAPEUTICS

Chairpersons: Marc Feldmann, Kennedy Institute of Rheumatology (UK) Tadamitsu Kishimoto, Osaka University (Japan)

09:00 PL4-20 Basic and Clinical Studies Involving IL-6 Receptor Blockade: TH17 Cells and Aryl Hydrocarbon Receptor. Tadamitsu Kishimoto, Osaka University, Japan.

09:30 PL4-21 Blocking IL-1 in Auto-infl ammatory Diseases. Charles Dinarello, University of Colorado School of Medicine, Denver, CO.

10:00 PL4-22 Blockade of the Lymphotoxin-LIGHT Pathway and the Treatment of Autoimmune Disease. Evangelia Hatzis, Adrian Papandile and Jeffrey Browning, Biogen Idec, Cambridge, MA.


11:00 PL4-23 Interferons in the Pathogenesis of Systemic Lupus Erythematosus. Mary K. Crow, Mary Kirkland Center for Lupus Research, Hospital for Special Surgery, Weill Medical College of Cornell University, New York, NY.

11:30 PL4-24 Treatment of Chronic Hepatitis B and C with Interferons. Lawrence M. Blatt, Alios BioPharma, South San Francisco, CA.

12:00 TBA



LATE BREAKING SESSION MARQUETTE

PATHOGENESIS AND THERAPY OF HEPATITIS B AND C VIRUS INFECTION

Chairpersons: Daniel Lamarre, Centre Hospitalier Université de Montréal (Canada) Santiago Duenas-Carrera, CIBG (Cuba)

14:00 LB-2 A Novel Innate Immune Antiviral Mechanism of Action of Ribavirin in Mammalian Cells Contributes to Effi cacy of Combination Therapy for Hepatitis C. Emmanuel Thomas, Zongyi Hu, Stephen Dong, Jordan J. Feld and T. Jake Liang, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD.

14:15 LB-54 A Soluble Form of the LDL Receptor Inhibits Hepatitis B Virus Replication in vitro. Ariel Werman, Brent E. Korba, Ben Alkahe, Danit Finkelshtein, Sergey Bujanover, Daniela Novick, Ernest Vinocour and Menachem Rubinstein, Dept. of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.

14:30 LB-265 Early but not Late Interferon Alpha Therapy Against Hepatitis C Rescues Polyfunctional CD4+ and CD8+ Memory T-Cells. Mohamed S. Abdel-Hakeem, Nathalie Bédard, Gamal Badr, Mario Ostrowski, Julie Bruneau, Rafi ck P. Sékaly, Bernard Willems, Jenny E. Heathcote and Naglaa H. Shoukry, Centre de Recherche du Centre Hospitalier de l’Université de Montréal (CHUM), Hôpital St-Luc, Université de Montréal, Montréal, QC.

14:45 LB-178 Changes in Gene Expression induced by Pegintron Plus Ribavirin in PBMC of Hepatitis C Patients During the First 10 Weeks of Treatment. Milton W. Taylor, Takuma Tsukahara, Jeanette N. McClintick, Howard J. Edenberg, Paul Kwo, Department of Biology, Indiana University, Bloomington, IN.

15:00 LB-165 Higher Effi cacy of Peg-IFN-α2 Ribavirin combined therapy in HCV-infected patients with functional myeloid dendritic cells (MDC). Ian Gaël Rodrigue-Gervais, Hawley Rigsby, Bernard Willems and Daniel Lamarre, Centre Hospitalier de l’Université de Montréal; INSERM Unité 743, Hôpital Saint-Luc, Université de Montréal, QC.

15:15 LB-253 Hepatitis C Virus NS3/4A Protein Downregulates Toll-like Receptor 7 Signalling Pathway. Maarit Sillanpää, Pasi Kaukinen and Ilkka Julkunen, Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland.

Thursday, October 16, 2008


Public Transport – www.stm.info

Public transport is a great way to get around Montréal. Notice those big blue signs with the white arrows? That’s the way to the city’s underground métro system—one of the safest in the world. The métro is fast and links all of downtown and major tourist destinations, as well as connecting to Montréal’s frequent bus service and the train. You can purchase individual tickets, or convenient one- or three-day passes for unlimited travel on bus and métro. If your trip requires both métro and bus, make sure to get a transfer from the bus driver or in the métro station (the tall silver boxes once you’re inside the turn-stiles); transfers are valid for 90 minutes. The time that is printed on it indicates when the validity period will end.

Fares: Adult fare (bus and métro): $2.75, 6 tickets: $12.00.

The metro and bus Tourist Card:

1 day, $9.00; 3 days, $17.00.

Offi cial Carrier

Air Canada is the offi cial airline carrier of Cytokines 2008. Discount rates are available from Air Canada on most routes. A promo-tion code will be provided along with your acknowledgement of registration.

Shopping

ONE OF THE GREAT SHOPPING CITIES OF THE WORLD – FIND OUT FOR YOURSELFMany major retail and specialty shops can be found on Saint Catherine St West. Most stores are open from 9 or 10 am to 6 pm Monday through Wednesday, to 9 pm on Thursday and Friday, and 9 or 10 am to 5 pm on Satur-day. Many stores are now also open on Sunday from noon to 5 pm.

Insurance, Liability

Neither the organizers nor Fairmont Queen Elizabeth can be held responsible for any personal injury, loss, damage, accident to private property or additional expenses incurred as a result of delays or changes in air, rail, sea, road or other services, strikes, sickness, weather, acts of terrorism and any other cause. All participants are encouraged to make their own arrangements for health and travel insurance.

General InformationExhibition

The exhibition will be open:Monday – Wednesday: 07:30 – 19:30Thursday: 07:30 – 10:30Please use all breaks to visit the exhibition stands.

Badges

Participants are asked to wear their name badges at functions during the conference.

Breakfast

A light breakfast (Coffee/Danish – “Breakfast on the Run”) will be served in the Foyer.Monday, Tuesday and Wednesday: 7:30 – 8:30

Coffee Breaks

Coffee/Tea/Water will be available in the Foyer Monday, Tuesday, and Wednesday Morning Coffee Breaks: 10:30 – 11:00Afternoon Coffee Breaks: 16:00 – 16:30

Lunch

Lunch break is “On Your Own” from 12:30 to 14:00. You can fi nd several restaurants and coffee shops in Place Ville Marie in the Underground City (map of the Under-ground and a list of restaurants are provided with the Program Book). Members of the Organizing Staff will be available in the Foyer to assist you.

Parking

Parking is available in the Metropolitan Parking garage located on the lower level, adjacent to the hotel (look for a green P sign). Indoor valet parking is also available at the Queen Elizabeth Hotel.

Bank

Opening hours: Monday to Wednesday: 10:00 to 16:00, on Thursday: 10:00 to 20:00, and on Friday: 10:00 to 16:00; 24 hours automated cash dispensers are located outside most banks.

Currency and Credit Cards

The currency is in Canadian dollars. Most hotels, restau-rants and shops accept internationally valid credit cards.

Language

English is the offi cial language of the conference. No simultaneous translation will be provided.


The Montreal Museum of Fine Arts will be holding an Andy Warhol Retrospective—that includes unique pieces from public and private collections. We have reserved the Glass Court at the Musée des Beaux Arts for delegates and guests of the Conference. The Museum is located at 1380 Sherbrooke St. West (corner of rue Crescent), a convenient 10-15 minute walk from the Fairmont Queen Elizabeth Hotel.

Social Program

Evening at the Notre Dame Basilica of Montreal


19:30h Meeting point at the hotel lobby of the Fairmont Queen Elizabeth Hotel.Included in the registration fee for participants and registered accompanying persons.

Dress Code: Casual

Opening Session – Welcome Reception

Sunday, October 12, 2008

20:30h in the Hochelaga rooms

Dress Code: Casual

All registered delegates and their accompanying persons are invited to attend the offi cial Opening Ceremony, to be followed by a Welcome Reception with a buffet dinner at the Fairmont Queen Elizabeth Hotel.

A special showing of “And Then There Was Light” —a light and sound spectacular at the historic Notre Dame Basilica in Old Montreal, followed by an exclusive organ recital by Pierre Grandmaison. The show recreates the history of Montreal and the Basilica; through the magic of fi lm projections, lighting and illustrations, you will relive a history fi lled with challenges and spectacular success. Additional information is available at the website www.

therewaslight.ca. The capacity of the Basilica is 300, and therefore it is necessary to reserve a spot for the program. A complimentary ticket for the evening at Notre Dame Basilica is provided to each registrant of Cytokines 2008 who signs up for the light show; additional tickets for a spouse and/or guest(s) may be purchased at the cost of $20 per person. Please note that tickets are available on a “fi rst come-fi rst serve” basis.

*Since the number of available places is limited, please be sure to register for this event.

Evening at the Montreal Museum

of Fine Arts


19:30h Meeting point at the hotel lobby of the Fairmont Queen Elizabeth Hotel.Included in the registration fee for participants and registered accompanying persons.

Dress Code: Casual


Gala Dinner


20:00h at Windsor Station

Dress Code: Evening Dress

Included in the registration fee for participants and regis-tered accompanying persons.

All registered delegates and their accompanying persons are invited to attend the Gala Dinner.

A Gala Dinner has been organized in the heritage Windsor Station which will be transformed into a magical Dream-

scape. Created by Mina Martini Events and Promotions, this unforgettable evening of entertainment will include music, dance and gravity defying acrobatics.

No other artist is as completely identifi ed with Pop Art as Andy Warhol. The media called him the Prince of Pop. Warhol made his way from a Pittsburgh working class family to an American legend. He studied commercial art at the Carnegie Institute of Technology in Pittsburgh; after graduation in 1949, he went to New York to work as an illustrator for magazines like Vogue and Harper’s Bazaar. He soon became one of New York’s most sought after and successful commercial illustrators.

In the sixties Warhol started painting daily objects of mass production like Campbell Soup cans and Coke bottles, quickly becoming a famous fi gure in the New York art scene. From 1962 on, he started making silkscreen prints of famous personalities like Marilyn Monroe and Elizabeth Taylor. The quintessence of Andy Warhol art was to remove the difference between fi ne arts and the commercial arts used for magazine illustrations, comic books, record albums or advertising campaigns. Warhol once expressed his philosophy in one poignant sentence: “When you think about it, department stores are kind of like museums”. In the 1970s, the philosopher of art produced individual portraits of the rich and affl uent of his time—Mick Jagger, Michael Jackson and Marilyn Munroe. Over time, Warhol’s activities became more entrepreneurial. In 1975 Warhol published The philosophy of Andy Warhol. In this book he describes what art is: “Making money is art, and working is art and good business is the best art.”

A complimentary ticket for the evening at Musée des Beaux Arts is provided to each registrant of Cytokines 2008; additional tickets for a spouse and/or guest(s) may be purchased at the cost of $20 per person.


From that offi ce, go back to the other end of the square and turn left (east) on:

5. Boulevard René-Lévesque: Formerly Dorchester Boulevard, this primary street was renamed in 1988 following the death of René-Lévesque, the Parti Quebecois leader who led the movement in favor of Québec indepen-dence and the use of the French language. Boulevard René-Lévesque is the city’s broad-est downtown thoroughfare, and the one with the fastest traffi c.

On the right is the:

6. Cathédrale Marie-Reine-du-Monde (Mary Queen of the World Cathedral): Built between 1875 and 1894 as the headquarters for Montréal’s Roman Catholic bishop, the cathedral is a copy of St. Peter’s Basilica in Rome, built to roughly one-quarter scale. The statue in front of the cathedral is of Bishop Ignace Bourget (1799-1885), the force behind the construction of the basilica. It was sculpted in 1903 by Louis-Philippe Hébert, who is also responsible for the statue of de Maisonneuve in the Place d’Armes in Vieux-Montréal.

Continue past the cathedral and cross rue Mansfi eld, and you will see:

7. Fairmont The Queen Elizabeth (Le Reine Elizabeth): Opened in 1958, Montréal’s largest hotel stands above Gare Centrale, the main railroad station, making it

most convenient for people arriving by train. It also has direct access to the un-derground city, and buses leave for Dorval and Mirabel airports from here.

Across boulevard René-Lévesque from Fairmont Le Reine Elizabeth hotel is:

8. Place Ville-Marie: Known as PVM to Montrealers, this massive structure was the gem of the postwar urban redevelop-ment efforts in Montréal. The skyscraper,

with its cross-shaped fl oor plan, was designed by I. M. Pei. It is meant to recall Cartier’s cross, planted on Mont-Royal to claim the island for France, and for de Maisonneuve’s fi rst little settlement, Ville-Ma-rie. The complex, completed in 1962, has a fountain in its plaza called Feminine Landscape (1972), executed by Toronto artist Gerald Gladstone.

At the end of the hotel, turn left along rue Université, crossing boulevard René-Lévesque and walking 2 blocks to rue Ste-Catherine. Turn right on rue Ste-Catherine and walk past avenue Union, where you’ll see:

9. Carré Phillips: This plaza contains a statue of Edward VII and, during much of the year, a farm stand selling Québec maple products.

GO TAKE A HIKE: A Walking Tour of Downtown

1. 1000 rue de la Gauchetière: This young contribution to the already-memorable skyline is easily identifi ed by its copper-and-blue pyramidal top, which rises to the maximum height permitted by the municipal building code. Inside, past an atrium planted with live trees, is a huge indoor skat-ing rink bordered by cafes with seat-ing for more than 1,500 spectators.

Walk west for 1 block on rue de la Gauchetière. On the left is:

2. Le Marriott Château Champlain: The hotel’s distinctive facade of half-moon windows inspired its nickname: the “Cheese Grater.”

Turn right on rue Peel, walking north. When you hit boulevard René-Lévesque, bear right and you’ll arrive at:

3. Square Dorchester: The square’s tall old trees and benches invite lunchtime brown-bag-gers. This used to be called Dominion Square, but it was renamed for Baron Dorchester, an early English governor, when the adjacent street, once named for him, was changed to boulevard René-Lévesque. Along the east side of the square is the Sun Life Insurance build-ing, built in three stages between 1914 and 1931, and the tallest building in Québec from 1931 until the skyscraper boom of the post-World War II era. This is a gathering point for tour buses and calèches. In winter, the calèche drivers replace their carriages with sleighs and give rides around the top of Mont-Royal.

At the northeast corner of the square is the main offi ce of:

4. Infotouriste Centre: Many useful maps and brochures are in stock here, most of them free for the taking. Visitors can ask questions of bilingual attendants, purchase tour tickets, change money, make hotel reservations, con-nect with the Internet, and rent a car.

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Over to the left, across rue Ste-Catherine, is:

10. Cathédrale Christ Church: Built from 1856 to 1859, this neo-Gothic building is the seat of the Anglican bishop of Montréal. The church garden is modeled on a medieval European cloister. The cathedral donated the land on which place de la Cathédrale and the shopping complex underneath it, Prom-enades de la Cathédrale, were built, in return for eventual ownership of the skyscraper and the underground complex. All those subterranean corridors and levels have caused some to dub it the “fl oating” or “fl ying” church.

Turn left on:

11. Rue Ste-Catherine: Head west through the center of Montréal’s shopping district. Many of Montréal’s department stores are along here, in-cluding, to the right of the church, La Baie (or “The Bay,” short for Hudson’s Bay Company, successor to the famous fur-trapping fi rm). Movie houses, cafes, shops, and several “adult” emporia line rue Ste-Catherine for several blocks.

At the corner of rue de la Montagne is:

12. Ogilvy: This is the most vibrant of a classy breed of department store that appears to be fading from the scene. Founded in 1866, it strives to maintain its upmarket stature by blend-ing tradition with tasteful marketing strategies. Its Christmas windows are eagerly awaited each year. A bagpiper announces the noon hour.

Continue 1 more block to:

13. Rue Crescent: This and nearby streets are the locus of the center-city social and dining district, largely yuppie Anglo in character, if not necessarily in strict demographics. Pricey boutiques, inexpensive pizza joints, upscale restaurants, and dozens of bars and dance clubs draw enthusiastic consumers looking to spend money and party the night away. This center of gilded youth and glamour was once a run-down slum area slated for demolition. Luckily, buyers with a good aesthetic sense saw the possibilities of these late-19th-century row houses and brought them back to life.

Turn right on rue Crescent and:

Take a Break – Lively spots for coffee or snacks are abundant along rue Crescent. Thursday’s (no. 1449, in L’Hôtel de la Montagne) is one, if you can fi nd a seat on the balcony, or walk a little farther up rue Crescent and get a sidewalk table at Sir Winston Churchill Pub (no. 1459).

Continue up rue Crescent, past boulevard de Maisonneuve, to the corner of rues Crescent and Sherbrooke. On this left corner, and on the opposite side of Sherbrooke, is the:

14. Musée des Beaux-Arts (Museum of Fine Arts): This is Canada’s oldest and Montréal’s most prominent museum. The modern annex

was added in 1991 and is connected to the original stately Beaux Arts building (1912) across the way by an underground tunnel that doubles as a gallery. Both buildings are made of Vermont marble.

Turn right on rue Sherbrooke, passing, at the next corner, the Holt Renfrew department store, identi-fi ed on its marquee only as HOLTS. Continue on rue Sherbrooke, passing, on the right, the:

15. Maison Alcan: This structure has been fre-quently lauded for its incorporation of 19th-century houses into its late-20th-century facade. Step inside the lobby to see the results, especially over to the right.

Walk 4 more blocks in the same direction. On the opposite side of rue Sherbrooke is the entrance to:

16. McGill University: The gate is usually open to this, Canada’s most prestigious university. Step inside and see, just to the left, a large stone that marks the site of the Amerindian Horchelaga settlement that existed here before the arrival of the Europeans.

Also on the campus is the:

17. Musée Redpath: Housed in a building dating from 1882, this museum’s main draw is its Egyptian antiquities collection, the second largest of its kind in Canada.

Opposite the university, and just half a block south of rue Sherbrooke, on the left, is a cream-colored resin sculpture called:

18. The Illuminated Crowd (1979): Raymond Mason’s sculpture is frequently photographed and widely admired for its evocation of the human condition, although its detractors fi nd it sentimental and obvious. Circle it at leisure and then return to rue Sherbrooke, turning right.

One block east on rue Sherbrooke is the:

19. Musée McCord: This private museum of Canadian history fi rst opened in 1921 and was substantially renovated and expanded in 1992. Named for its founder, David Ross McCord (1844-1930), the McCord has an eclectic and often eccentric collection of 80,000 artifacts. Furniture, clothing, china, silver, paintings, photographs, and folk art reveal elements of city and rural life from the 18th to the 20th century. Amerindians are represented in the First Nations room.

To return to the Fairmont Queen Elizabath Hotel con-tinue east on rue Sherbrooke to rue University, then

turn right (south) and walk down to boulevard René-Lévesque. The hotel is a half block to your right.


OF EVERY CELLTHE MOST

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Cytokines_show_Outline.indd 1 8/12/08 10:07:05 AM


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TORONTO MONTRÉAL VANCOUVERJoan Lister Gabrielle Collu Ann Gibbon

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Pfi zer Canada Inc. est la fi liale canadienne de Pfi zer Inc, première entreprise pharmaceu-tique à l’échelle mondiale, et elle est située à Kirkland, au Québec. Pfi zer découvre, met au point, fabrique et commercialise des médicaments d’ordonnance pour les humains et les animaux. Pfi zer Inc investit plus de sept milliards de dollars américains par année dans la recherche et le développement pour découvrir et mettre au point des médicaments d’importance vitale ou qui améliorent la qualité de la vie dans divers domaines thérapeu-tiques. Le siège social mondial de la Société se trouve à New York, où elle a été fondée en 1849.

Durant la Seconde Guerre mondiale, Pfi zer est devenue le premier fabricant de pénicilline à l’échelle industrielle, ce qui l’a propulsée dans l’ère moderne de l’industrie pharmaceutique. Pfi zer Canada possède maintenant une Division des marchés spécialisés, dont l’objectif est de faire progresser les connaissances scientifi ques sur les maladies qui se rapportent aux domaines de l’oncologie, du VIH, des maladies infectieuses, de l’endocrinologie et de l’ophtalmologie. À l’heure actuelle, l’oncologie est le premier secteur de recherche en importance pour ce qui est de la somme investie en recherche et développement.

Pfi zer Canada, qui est un chef de fi le en matière de recherche sur les soins de santé, a investi plus de 137 millions de dollars dans les travaux de recherche et de développement, les contributions et les partenariats en 2007. Depuis 2000, la Société a injecté plus d’un milliard de dollars dans la recherche-développement. Fière de fi gurer parmi les membres du Programme des entreprises généreuses d’Imagine Canada, Pfi zer Canada est l’une des principales sociétés donatrices du pays. Grâce à son programme d’engagement commu-nautaire, Pfi zer Canada a contribué à plus de 1 400 projets et organisations sans but lucratif partout au pays, versant au total plus de 25 millions de dollars, en 2007.

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PFIZER IN CANADA

Pfi zer Canada Inc. is the Canadian operation of Pfi zer Inc, the world’s leading pharmaceutical company and is located in Kirkland, Quebec. Pfi zer discovers, develops, manufactures and markets prescription medicines for humans and animals. Pfi zer Inc invests more than US$7 billion annually in R&D to discover and develop innovative life-saving and life-enhancing medicines in a wide range of therapeutic areas. Global headquarters are located in New York City, where the company was founded in 1849.

During the Second World War, Pfi zer became the fi rst company to mass-produce penicillin, launching Pfi zer into the modern pharmaceutical era. Pfi zer Canada now has a Specialty Division which is committed to advancing the scientifi c understanding of diseases in the areas of oncology, HIV, infectious diseases, endocrinology and ophthalmology. Research in oncology now represents the Pfi zer’s largest research and development investment.

Pfi zer Canada is a leader in Canadian healthcare research, investing more than $137 mil-lion in research and development activities, contributions and partnerships in 2007. The company has invested more than $1 billion in R&D since 2000. As one of the top corporate charitable donors in Canada, Pfi zer Canada is a proud member of Imagine Canada and its Caring Company program. In 2007, Pfi zer Canada’s Community Investment Program sup-ported more than 1,400 non-profi t organizations and projects across the country with a total investment of over $25 million.

For more information, visit www.pfi zer.ca.

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