54 http://news.hankooki.com/lpage/society/200510/h2005102611275921950.htm 01 28 02 33 03 38 04 42 05 46 06 51 07 56 08 60 09 66 10 DHA 72 11 77 12 82 13 88 14 , 94 15 100 16 104 17 108 18 114 19 118 20 DNA 122 21 2 126 22 130 23 134 24 138 25 142 26 146 27 150 28 155 29 159 30 163 31 167 32 171 33 175 34 180 35 184 36 188 37 192 38 196 39 200 40 204 41 208 42 , 212 43 10 216 44 220 45 224

1/104

46 47 48 49 50 51 52 53 54

228 232 236 241 245 249 2 254 258 261

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01 1 . 2002 24 6 25% 6 2 . , . . . 1 ( ) ' ' , 50 . . (=) 10 . , , , . . .. , ... . . , , , , . . 50~90% . '' () . , , , .

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. 75~76% 2 17 , B1 B2 3 , E 4 . E, , , , , , . . . . . . . 41% . , , , . , , , . . . . , . . , . .

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, , , , . ( = , )

5/104

02 ? ' 5 ' , , , . (, , ) (, ,, , ), (, , , , , , ), (, , , ), (, , ) . 5 . . 2 5 , 10 . . 30 , . , , , , , , , ,, , , . . , . , , . A ( ) . , . , , . .

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2 , . C, E, , . ( = , )(=)

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03 . , . , , 8% . 40 t . . , , , A , , B , , . , 70% , , . -6 -3 (PUFA) . , DHA() EPA() -3 , . , , . , . 9.5~14.5% . , .

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, TNF-a . (ACE) , (ACE inhibitor) . . , . . ( = , )

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04 1 , , , . () , . , , () () () , () . , . , , , , , . 64.9%, 15.1%, 6.4%, 2.8%, 2.0%, 8.8% 147mg/100g . . , , , , , , A, B, C , 6- . ( ) . - . . , , , , , , , , 2~20 . . G2/M , () . - , . - .

10/104

. . . ( = , )

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05 . 4 , . 1986 , , , , . , ( A ) , (NCI) , , , . B1, B2, C E() , C(100g 25mg) 70-80% . . , , (1763 ) . . , , . . , . 6g , 12g , 100g 460 . . 170 Kcal (100g 130Kcal) .

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. . 2 , . , ? ( = , )

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06 . . . 20 . , 3 . . . 3 . . . (Cdks) G2/M . . , . 1 67 27.3 mg . 10.68mg, 3.34mg, 2.44mg, 2.42mg, 1.12mg, 1.02mg, 0.33mg, 0.29mg .

14/104

, . . ( = )

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07 . (:) . , , . 20~30cm . 100g 318, 14. 9%, 27.1g, 0.6g, 53.8g, 11.6g, 3.6g, 97. 9g, 70mg, 0.5g, 2.0mg, 1.0mg . A, C B 4~5 . A , . '' B3 . . . , . , , . . , . , . . .

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(SNU778), (SNU719), (Hep3B) (A253), (Jurkat-T) . 50% IC50 . . (1:1) . 5 . ( = ) (=)

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08 , , . 40 23 . . , , . . , . ( ) G2-M . , . . . . , . , , , . ( , )

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09 , . , , , . 100 90 . . , , , , . . . , , . , . , . 17 . . 40 . , , E, , , , . . , .

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. 12 . . ( = , ) (=)

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10 DHA . , , , , . , . 17 26 5 . , , 2 , 2.6 , 2.4 . ? EPA() DHA() . EPA 1990 . 1994 . DHA , DHA . EPA , , . . EPA . . DHA . DHA , DHA (PGE2) . .

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. DHA . 2 DHA . DHA . . , , , DHA 3 DHA . DHA . . .

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11 15~20 2~3 . . . . . . . . . . . . ( ) . 70 . . ( 5 ~1 , 3 ~5 ,1 ~3 ) , 1kg 50mg 24 1 1

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(3 ~5 ) 74% . . MMP-2(Metrix metalloproteinase-2) MMP-2 . , . . , . . ( = )

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12 ? ' 5 ' , , , . (, , ) (, ,, , ), (, , , , , , ), (, , , ), (, , ) . 5 . . 2 5 , 10 . . 30 , . , , , , , , , ,, , , . . , . , , . A ( ) . , . , , . .

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2 , . C, E, ? , . ( = , )(=)

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13 , , . . , , , . C 100g 83-146mg 3 . 127mg/100g 187mg/100g 320mg/100g 105mg/100g 3 . 32-36% , -3- (I3C), . NNK, , phIP . (PEITC) I3C . PEITC 1 2 GST . G2/M ( ) . 10 . , , , DNA . , . . , -180 62-71% 3 . , , , , ,

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. , , , . C , , , I3C, . , , . ( = , )

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. . . , , , . . , . . . , , , , , . , (). . 100g 36 78 . ( A ) . , , , . . , . , . , . ( ) . .

29/104

, . . 100g 181 . 100g 100 ( ). . . C , , . Seed World(98 9 ) , . , , .

, , . , , , . 2 8 . . , , WHO()" " " " . 3 , 52 . 65 , 65 . A B1 B2 C

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(200 g) 52 405 3 7 9.5 (100 g) 65 25 1.4 28 9.5 (200 g) 52 20 1.9 5.5 9.5 (400 g) 22 0.56 7 9.5 (100 g) 37 3 28 19 (180cc) 3 45 4.6 2.3 210 1 (180cc) -

476.5 128.9 88.8 39.06 87 264.9 [ ]

. . . . . . . . . , , , . . . . . , . . , , , , () .

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14 , ( ) . . . . . . C 2 , A B1, B2, , , . . . . (-N=S=S ) (sulforaphane) . . 2 , . , DNA , . .

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. , , DNA ? . . , . . 20% , . 20% . , C . , . ( = , )

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15 . , . . . 1 . . 3, 4 . , . . , 40 . . . 1 . , , , , , , , ? .

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, . ( = , )

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16

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17 . . . (magic bullet) , ' ' . . , . 3 (, ,) . , , . 90.6 100 7.3 , 1.5 , 0.2 , 0.8 , 0.6 , 38 , 16 , 0.4 , C 29 . B1, B2 U . , (ITC), -3- (I3C), , . . ITC . ITC , . ITC .

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ITC -3- . -3- . . . ITC -3- , . . 1 1 1.5 72% . . . . , , , , . , 30-70 . ( = , )

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18 ' ' . 10 . , , . ( ) (0.04ppb) . . (8) MNNG . . MNNG . 3 . . , , , . 1 1 . . . ( ) . , . , SOS , , , . .

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, 3-, , C , , E, , , , . . , , (1 ) . , . . (5) . ( = , )

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19 . . , , . 1970 . C 2 , B1, B2, . , , . , , . . . DNA DNA . , DNA . . . 54 18 6 2 ( 300 ml) DNA , . DNA 32%, 29% . LDL- .

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C, , . DNA , DNA . . , . . ? ( = )

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20 DNA . A C K , . . 12 , 22% . A A . A A . . 35%, 40% . DNA . DNA . . 31% . . 100g ( 6 ) 200 . , , B12 . C 100g 65 C . C .

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. . . C . C 3% C . . ( = , )

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21 2 . , A C, , . `' `' ` , . ' . , . , . , , , . , , . , , , , . G2/M , . , (retinoblastoma protein) . G1 S . , , , . , . . 60% . .

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, , . , , . ( = )

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22 , , , , , (Ligularia fischeri{Ledeb} Turcz.) . 1 . . . . 7~9 5~9 . . . . . (: :, :: ), (: ), (: ) , , ,

. . . . 5 , .

. . .

. '' ? ? ()

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. () .

.

[()

(Ligularia

fischeri

{Ledeb.}

Turcz.)

.

. , , , , , , , , , .] . ' ' . , .

. . ( ) 34 6 .

() . , , , , , . , . .

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'' , .

[()

// // [] [Ligularia fischeri(Ledeb) Turcz.] . .

. . . , , , , , . 3~9 . , , , , , , .]

.

[(igularia fischeri(Led) Turcz.) : 1 . . ; .

. : (1.2%), (0.44%), (0.04%), (0.05%), 6--(0.01%) . , 190mg% .

:

.

: , , , . , , .]

isopentenic acid, 10-H-furanoligularone . ligularone, liguloxide, liguloxidol acetate .

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. , , . , , , , , , .

.

4~12 () .

(: ) . , () . () " 80 1 2 , 1 8 () ." .

, , . . . . 50 . .

(/ )

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23 . . 1 ha . 93% ( ) 100g 0.9g, 0.1g, 4.5g - 32 c 9mg . . , . 80% . . , 2 , . , , , . . . . , , , , . , , , . 1 1 2kg 100g .

51/104

, . . ( = , )

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24 , . () . , , , , , , , . (triterpenoid) . , , , , , , , , . , (inulin) . , 2000 . . , . . . , , , (apoptosis) . (telomere) DNA . , .

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, . . , . , , . . ( = , )

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25 . 1 . 90% , , . , B C, , , . . . 100 18.3mg . . . . . () . , . . .

55/104

. 3 1 . 1 . ( = , )

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26 . . 1 5.1 , 2-4 . , , , , . A C . C , A . (capsaicin) . 0.1% 1% . , . 2 . . , , . , . . , , , .

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. . . , . . . , . DNA , . , . . . . ( = ) (=)

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27 . 2002 10 48 . . LDL HDL . (, , ) . DNA . . 1 2 . (Helicobactor pylori) . . B T . (natural killer) . . . 75 3 . 100 . , .

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. . . . ? ? . 10 . . . ( = KAIST , )

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28 . . 35 . . . . , . . , . . 6-(gingerol) . 6- . . '' . 6- . 6- (Shogaols) . .

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6- . . , . . . , , , , , . . . ! . ( = , )

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29 , . . . `' , , . . . . . , , . 1 1 , 32 . , . . DNA DNA . DNA .

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. . DNA , . . . . . ( = )

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30

65/104

31 , . ,, , . . , , , , . , , , . A, B1, C . , . , , . , . Ames() , . G2/M . , . , . , A C .

66/104

, . ? ( = , )

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32

68/104

33 2 1 . 400 25~30 . , , , , . . . , . , , , . . . . , . , . . . , . .

69/104

. . . . ( = , )

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34 45 ,, . . . , , , , , , , , , , . , , , , . . , . . , . , . . DNA DNA . . DNA . .

71/104

, . . ( = )

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35 16 . 25kcal C A . , . (Giovannucci) 5 6 46 , , , , . . 2 . . . 1 3 . . 100g 55.45mg > > > > . . , . . ( = )

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36 . 200~300 6 . , . . , A . . , . . , , , , , , . . 1 . . . , , . , , . ( = , )

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37 , , . , . , . , , . , , , , , , ppm . . . , . , . . , , . . . , . , .

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, , , . ( = )

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38 (1123 ) `' " . " . 1451 ( ) . . , . 1 7.5g , . , . 20-30% . . 30 , 72 . . . . . T (Adult Tcell lymphoma:ATL) . ATL . , .

77/104

. . . ( = )

78/104

39

79/104

40 . , . , ' (French paradox)' . , (resveratrol) . , , . 100 5-10mg , 1.5-3mg , . 1997 , 3 , . , , , , . . . , , . , .

80/104

. ( = , )

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41 ( 35) ( 30). 65 . . , . , , , . , . DNA . () , . . . , . 10-13 1g 15-25mg . 0.2, C 100g 3-6mg 75 25 . 100g 150mg, 100g 1-2g 1kg 20-45mg . 85-88 , , .

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120 . . , . . - 1 4 1 ( 200g)- 2 1 (400g) . . ' ' , ' ', ' ' , . ( = )

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42 , . , , . , , . . () . , . , , , , , . , . , , . , , , . . . . 2 . , , , , . .

84/104

, , . 4 , . (?= , )

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43 10 100-1 300m . 30 cm . , , , , , , , , , , , . 2000 289t 2005 1 127t . 80% , 0.87-1.00%, 0.25-0.60%, 11.9519.00%. , 4 , , , , . , 50 mg/kg, 150 /(), 60 /g(. 10 ) , , , , () . , 72 . ' ' . . 3 , 3 . , I CYP450 . DNA , DNA . -2, (iNOS) , , . . ( ), .

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, , , . . . . ( ) . ( = )

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44 , () . , 3 . . . . , , . . B2 . . . , , . . ' ' " 71.9% " . , . , . , (pH) . , .

88/104

.. . 10g 120ml 50% ( 38%) . 0-157 . . B2 . pH , . ? ( = )(=)

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45 55 6 1%, 7.7% . 2002 10.6% 2010 , . . 1858 . `' , (Leuconostoc mesenterioids Lactobacillus plantarum) . 4 , 1970 . . . - . . ( = )

46

90/104

. () (), . () . 40%, 16%, 20%, 18% . 54%, 13%, 19% . , , 0.3~0.8% . , .. . 3 , . , . . . . . , , . A C, . () . , .

91/104

. . 30 . . . ( = , )

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47 8 1 . . . (41%), (20%) (28%) -3 , , . -3 -6 -6 . -3 1% 8% 57% -3 . -3 . . , , , , 75800 . , , . . . . .

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1 25g 32-39 . . , 30g . . . . , . 25g . ( = , )

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48 , . 3 , '' 5 , , (lentil), . . 70% . . , . . . 'HER-2/neu' . ''() . . , . , , . , , . , , , .

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A , . . , . , . , . , , , ? ( = , )

96/104

49

97/104

50 (1 10 25 ) . () . . , , . . , , , . 84 10 42 (placebo) 42 , DNA . 2.7g() 10 , . ( )

98/104

51 " " ( . , () ). . , . ` ' . 300 4000 . 50 . , , 18 , 150 . , , , . , . Cancer Letter J. Agricultural Food and Chemistry , , , , . 1 . . , . .

99/104

, . , , , , . . . . . ( = )

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52 2 . . 30 . , (Camellia sinensis) . 10 . 1976 (Michael Sporn) ' '(cancer chemoprevention) (cancer risk) . , . . (catechin) (polyphenol) , , , . EGCG , , , , , . . , , . , , , . ? ( = )

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53 0.5~6.5 (Curcumin). , , . , . . NF-kappaB . . , ` 8' . , , . 1 , . , . , . , , . ( = )

54 .

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. 34 , , . , , (SARS.) , . . , , , , , . . , . . . 1996 12 37% 49% 10 . . 63%, 58%, 46% . 43% 200 45% . , , , , , , . , . . , .

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, . 65 (100) . B T (naturalkiller) . , , 70-80% . . , , . , , , , . . . ( = , )

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