2004-2005Cardiovascular SystemPharmacology Review

April 21, 202306:49 PM

Acebutolol

Sympatholytic1 adrenergic antagonist

AntihypertensiveAntianginal

AntiarrhythmicBronchoconstrictor

Acetylcholine

Cholinomimetic

AntigluacomaMuscle contraction (nicotinic

receptor)

Adenosine

Antiarrhythmic

Miscellaneous(does not fit class I-IV organization)

Albuterol

Sympathomimetic2 adrenergic agonist

Short acting bronchodilatorUsed in asthma

Amiodarone

Class I/III antiarrhythmic

Na+ and K+ channel blocker(inactivated channels)

Amphetamine

Indirect sympathomimeticDrug of abuse

ADD treatmentStimulant

Amyl nitrite

Vasodilator

Antianginal Aerosol

Angiotensin II

Autacoid

Vasoconstrictor

Atenolol

Sympatholytic1 adrenergic antagonist

AntihypertensiveAntiarrhythmic

AntianginalBronchoconstrictor

Atorvastatin

Antihyperlipidemic

HMG-CoA reductase inhibitor

Atropine

Anticholinergic

AntimuscarinicTreatment for bradycardia,

diarrhea, cholinesterase poisoning

Betaxolol

Sympatholytic1 adrenergic antagonist

AntihypertensiveGlaucoma medicationBronchoconstrictor

Bethanecol

Cholinomimetic

Muscarinic agonistInduces defecation and

urinationBronchoconstrictor

Biltolterol

Sympathomimetic2 adrenergic agonist

Bronchodilator

Bretylium

SympatholyticClass III antiarrhythmic

K+ channel blocker

Candesartan

Antihypertensive

Angiotensin receptor blocker(ARB)

Captopril

Antihypertensive

Converting enzyme inhibitor Heart failure treatmentAngioedema producer

Cholestyramine

Antihyperlipidemic

Bile acid binding resin (BABR)

Clofibrate

Antihyperlipidemic

Lipoprotein lipase activator

Clonidine

Sympatholytic2 adrenergic agonist

Antihypertensive

Colestipol

Antihyperlipidemic

Bile acid binding resin (BABR)

Diazoxide

Vasodilator

Antihypertensive

Digitalis

Cardiac glycosideAntiarrhythmic

Na+/K+ ATPase inhibitor Positive inotrope

Miscellaneous(does not fit class I-IV organization)

Digitoxin

Cardiac glycosideAntiarrhythmic

Na+/K+ ATPase inhibitor Positive inotrope

Miscellaneous(does not fit class I-IV organization)

Digoxin

Cardiac glycosideAntiarrhythmic

Na+/K+ ATPase inhibitor Positive inotrope

Miscellaneous(does not fit class I-IV organization)

DIG-specific antibody fragments

Antidote

Cardiac glycoside poisoning

Diltiazem

Class IV antiarrhythmicAntihypertensive

Ca2+ channel blocker

Disopyramide

Class I antiarrhythmic

Na+ channel blocker(activated channels)

Dobutamine

Sympathomimetic1 adrenergic agonist

Inotrope

Dofetilide

Class III antiarrhythmic

K+ channel blocker

Dopamine

Sympathomimetic

InotropeVasodilator

Doxazosin

Sympatholytic1 adrenergic antagonist

Antihypertensive

Ecothiophate

Anticholinesterase

VasodilatorBronchoconstrictor

Glaucoma treatment

Edrophonium

Anticholinesterase

VasodilatorDiagnostic for myaesthenia

gravisBronchoconstrictor

Enalapril

Antihypertensive

Converting enzyme inhibitorAngioedema producer

Ephedrine

Indirect sympathomimetic

VasoconstrictorBronchodilatorDecongestant

Epinephrine

Sympathomimetic and adrenergic agonist

VasoconstrictorBronchodilator

Eprosartan

Antihypertensive

Angiotensin receptor blocker(ARB)

Esmolol

Sympatholytic1 adrenergic antagonist Class II Antiarrhythmic

AntihypertensiveBronchoconstrictor

Ezitimibe

Antihyperlipidemic

Cholesterol absorption inhibitor

Fenofibrate

Antihyperlipidemic

Lipoprotein lipase activator

Flecainide

Class I antiarrhythmic

Na+ channel blocker

Fluvastatin

Antihyperlipidemic

HMG-CoA Reductase Inhibitor

Fosinopril

Antihypertensive

Converting enzyme inhibitor

Gemfibrozil

Antihyperlipidemic

Lipoprotein lipase activator

Guanabenz

Sympatholytic

Antihypertensive

Guanadrel

Sympatholytic

Antihypertensive

Guanethidine

Sympatholytic

Antihypertensive

Guanfacine

Sympatholytic2 adrenergic agonist

Antihypertensive

Hydralazine

Vasodilator

Antihypertensive

Ibutilide

Class III antiarrhythmic

K+ channel blocker

Imipramine

Indirect sympathomimeticTricyclic antidepressant (TCA)

Antimicturant

Isoproterenol

Sympathomimetic adrenergic agonist

VasodilatorBronchodilator

Isosorbide dinitrate

Venodilator

Used to treat CHF

Lidocaine

Class I antiarrhythmicLocal anaesthetic

Na+ channel blocker(activated and inactivated channels)

Lisinopril

Antihypertensive

Converting enzyme inhibitorHeart failure treatmentAngioedema producer

Losartan

Antihypertensive

Angiotensin receptor blocker(ARB)

Lovastatin

Antihyperlipidemic

HMG-CoA reductase inhibitor

Malathion

Anticholinesterase

VasodilatorBronchoconstrictor

Metaproterenol

Sympathomimetic2 adrenergic agonist

BronchodilatorUsed in asthma

Methacholine

Cholinomimetic

Bronchoconstrictor

Methoxamine

Sympathomimetic1 adrenergic agonist

Vasoconstrictor

Methydopa

Sympatholytic2 adrenergic agonist

Antihypertensive

Methylphenidate

Indirect sympathomimeticDrug of abuse

ADD treatmentStimulant

Metoprolol

Sympatholytic1 adrenergic antagonist

AntihypertensiveHeart failure medication

Bronchoconstrictor

Mexilitine

Class I antiarrhythmic

Na+ channel blocker(activated and inactivated channels)

Minoxidil

Vasodilator

Antihypertensive

Moezipril

Antihypertensive

Converting enzyme inhibitor

Moricizine

Class I antiarrhythmic

Na+ channel blocker

Nadolol

Sympatholytic adrenergic antagonist

Antihypertensive

Neostigmine

Anticholinesterase

VasodilatorTreatment for myaesthenia gravisPromotes defecation and urination

Bronchoconstrictor

Nicotine

CholinomimeticDrug of abuse

Nicotinic receptor agonist(skeletal muscle contraction)

StimulantSmoking cessation medication

Nicotinic acid

Antihyperlipidemic

Inhibition of VLDL secretion (?)

Nifedipine

Antihypertensive

AntianginalCalcium channel blocker

Nitroglycerine

Venodilator

Antianginal

Nitroprusside

Vasodilator

Antihypertensive

Norepinephrine

Sympathomimetic

Vasoconstrictor

Perindopril

Antihypertensive

Converting enzyme inhibitor

Phenoxybenzamine

Sympatholytic adrenergic antagonist

Antihypertensive

Phentolamine

Sympatholytic adrenergic antagonist

Antihypertensive

Phenylephrine

Sympathomimetic 1 adrenergic agonist

VasoconstrictorNasal decongestant

Phenytoin

AnticonvulsantClass I antiarrhythmic

Na+ channel blocker(inactivated channels)

Physostigmine

Anticholinesterase

BradycardicVasodilator

Bronchoconstrictor

Pilocarpine

Cholinomimetic

Muscarinic agonistAntiglaucoma

Bronchoconstrictor

Pindolol

Sympatholytic adrenergic antagonist

AntihypertensiveBronchoconstrictor

Pravastatin

Antihyperlipidemic

HMG-CoA reductase inhibitor

Prazosin

Sympatholytic1 adrenergic antagonist

Antihypertensive

Propranolol

Sympatholytic adrenergic antagonist Class II antiarrhythmic

AntihypertensiveBronchoconstrictor

Pseudoephedrine

Sympathomimetic and adrenergic agonist

VasoconstrictorNasal decongestant

Pyridostigmine

Anticholinesterase

VasodilatorTreatment for myaesthenia

gravisBronchoconstrictor

Quinapril

Antihypertensive

Converting enzyme inhibitor

Quinidine

AntimalarialProtein and nucleic acid

synthesis inhibitor

Class I antiarrhythmic

Intercalates in DNABinds to ferriprotoporphyrin

Na+ channel blocker

Ramipril

Antihypertensive

Converting enzyme inhibitor

Reserpine

Sympatholytic

Antihypertensive

Sildenafil

Vasodilator

Promotes erection

Simvastatin

Antihyperlipidemic

HMG-CoA reductase inhibitor

Sotolol

Class II antiarrythmicSympatholytic

adrenergic antagonist

Terazosin

Sympatholytic1 adrenergic antagonist

AntihypertensiveTreatment for benign prostatic

hypertrophy

Terbutaline

Sympathomimetic2 adrenergic agonist

Short acting bronchodilator Tocolytic

Uterine relaxant

Timolol

Sympatholytic adrenergic antagonist

AntihypertensiveGlaucoma treatment

Anti-anginalBronchoconstrictor

Tocainide

Class I antiarrhythmic

Na+ channel blocker(activated channels)

Trandopril

Antihypertensive

Converting enzyme inhibitor

Trimethaphan

SympatholyticAnticholinergic

Nicotinic antagonistAntihypertensive

Tyramine

Indirect sympathomimetic

VasoconstrictorVasopressor

Valsartan

Antihypertensive

Angiotensin receptor blocker(ARB)

Verapamil

Class IV antiarrhythmicAntihypertensive

L-type Ca2+ channel blocker Antianginal