2021 aas virtual program - americanautonomicsociety.org

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32 ND INTERNATIONAL SYMPOSIUM ON THE AUTONOMIC NERVOUS SYSTEM AAS Virtual Meeting November 4-6, 2021 Meeting Program THURSDAY, NOVEMBER 4, 2021 10:30-10:45 AM Eastern President’s Welcome Steven Vernino, M.D., Ph.D. President, American Autonomic Society 10:45-11:45 AM Eastern Plenary Lecture 1: Robertson Plenary Lecture Autonomic regulation in spinal cord injury Victoria Claydon, Ph.D. Burnaby, BC, Canada Chairs: Steven Vernino and Brooke Hockin 11:45-11:55 AM Eastern Break Session 1a: Spinal Cord Injury Chairs: Glen Cook and Vera-Ellen Lucci 11:55 AM-1:10 PM Eastern Parallel session 11:55-12:10 PM Spinal cord injury necessitates controlled breathing to index cardiac vagal modulation from respiratory sinus arrhythmia J.A. Taylor, G. Schleifer, R. Solinsky Boston, MA, USA (Poster 134) 12:10-12:25 PM Long-term neuroprosthetic hemotherapy treats autonomic dysreflexia after spinal cord injury J.E. Soriano, R. Hudelle, J.W. Squair, M.A. Anderson, M. Gautier, M. Tso, G. Courtine, A.A. Phillips Calgary, AB, Canada (Poster 133) 12:25-12:40 PM Long-term neuroprosthetic hemotherapy prevents aberrant hyperreflexive plasticity after spinal cord injury M.M. Tso, J.E. Soriano, R. Hudelle, J. Squair, M. Anderson, M. Gautier, G. Courtine, A.A. Phillips Calgary, AB, Canada (Poster 136)

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Page 1: 2021 AAS Virtual Program - americanautonomicsociety.org

32ND INTERNATIONAL SYMPOSIUM ON THE AUTONOMIC NERVOUS SYSTEM

AAS Virtual Meeting November 4-6, 2021

Meeting Program

THURSDAY, NOVEMBER 4, 2021 10:30-10:45 AM Eastern

President’s Welcome Steven Vernino, M.D., Ph.D. President, American Autonomic Society

10:45-11:45 AM Eastern

Plenary Lecture 1: Robertson Plenary Lecture Autonomic regulation in spinal cord injury Victoria Claydon, Ph.D. Burnaby, BC, Canada Chairs: Steven Vernino and Brooke Hockin

11:45-11:55 AM Eastern

Break

Session 1a: Spinal Cord Injury Chairs: Glen Cook and Vera-Ellen Lucci 11:55 AM-1:10 PM Eastern Parallel session 11:55-12:10 PM Spinal cord injury necessitates controlled breathing to index cardiac vagal

modulation from respiratory sinus arrhythmia J.A. Taylor, G. Schleifer, R. Solinsky Boston, MA, USA (Poster 134)

12:10-12:25 PM Long-term neuroprosthetic hemotherapy treats autonomic dysreflexia after spinal cord injury J.E. Soriano, R. Hudelle, J.W. Squair, M.A. Anderson, M. Gautier, M. Tso, G. Courtine, A.A. Phillips Calgary, AB, Canada (Poster 133)

12:25-12:40 PM Long-term neuroprosthetic hemotherapy prevents aberrant hyperreflexive plasticity after spinal cord injury M.M. Tso, J.E. Soriano, R. Hudelle, J. Squair, M. Anderson, M. Gautier, G. Courtine, A.A. Phillips Calgary, AB, Canada (Poster 136)

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Session 1b: Autonomic COVID 12:40-12:55 PM Dysautonomia symptoms in post-acute COVID-19 patients after hospital discharge:

one-month follow-up S. Rigo, F. Barbic, M. Minonzio, G. Putti, A. Bisoglio, M.A. Romeo, F. Pellizon, S. Kulangarathottiyil, L. Bresciani, P. Verzeletti, F. Badilini, M. Ciccarelli, M.G. Bordoni, R. Furlan Milan, Italy (Poster 39)

12:55-1:10 PM Autonomic dysfunction following COVID-19 infection: an early experience K. Shouman, G. Vanichkachorn, W.P. Cheshire, M.D. Suarez, S. Shelly, G.J. Lamotte, P. Sandroni, E.E. Benarroch, S.E. Berini, J.K. Cutsforth-Gregory, E.A. Coon, M.L. Mauermann, P.A. Low, W. Singer

Rochester, MN, USA (Poster 36)

Session 2: Human Physiology Chairs: Jacqueline Limberg and Chloe Taylor 11:55 AM-1:25 PM Eastern Parallel session 11:55-12:10 PM Short-term hypercaloric diet decreases hypothalamic and brainstem functional

connectivity in humans D.A. Gerlach, J. Manuel, A. Ewald, A. Hoff, R. De Gioannis, M. Heer, J. Tank, J. Jordan Cologne, Germany (Poster 62)

12:10-12:25 PM Effect of nitroglycerin and sympathetic withdrawal on splanchnic capacitance and cardiac blood volumes L.E. Okamoto, W.D. Dupont, S.Y. Paranjape, J.E. Celedonio, E.C. Smith, M.W. Kronenberg, I. Biaggioni Nashville, TN, USA (Poster 32)

12:25-12:40 PM Role of endothelin-1 on the sympathetic and hemodynamic response to acute intermittent hypoxia in men J.K. Limberg, S.E. Baker, D.W. Jacob, E.P. Ott, Z.M. Scruggs, J.L. Harper, C.M. Manrique-Acevedo Columbia, MO, USA (Poster 50)

12:40-12:55 PM Effects of chronic pelvic pain on ambulatory heart rate variability in women D.P. Williams, C.R. Wiley, M. Merritt, P. Simpson, L. Conant, F. Tu, J. Janata, G. Chelimsky, J.F. Thayer, T. Chelimsky Irvine, CA, USA (Poster 61)

12:55-1:10 PM Exaggerated sympathetic neural responses to the cold pressor test in heart failure with preserved ejection fraction R. Takeda, S.L. Hissen, S.W. Holwerda, J.P. MacNamara, S. Sarma, P.J. Fadel, B.D. Levine, Q. Fu

Dallas, TX, USA (Poster 35)

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1:10-1:25 PM Orthostatic tolerance before and after 60 days of strict head down tilt bedrest with and without daily artificial gravity training J. Hoenemann, F. Hoffmann, S. Moestl, K. Heusser, E. Mulder, A.E. van Herwaarden, S.M.C. Lee, J. Jordan, J. Tank Cologne, Germany (Poster 28)

1:25-1:45 PM Eastern

Break

1:45-2:15 PM Eastern

The Felicia Axelrod Award Pure autonomic failure: from idiopathic OH to phenoconversion Elizabeth A. Coon, M.D. Rochester, MN, USA Chair: Wolfgang Singer

2:15-2:25 PM Eastern

Break

Neurogenetics Symposium Chairs: Lucy Norcliffe-Kaufmann and Patricio Millar Vernetti 2:25-3:55 PM Eastern 2:25-2:45 PM What congenital insensitivity to pain teaches us about blood pressure control

Lucy Norcliffe-Kaufmann, Ph.D. New York, NY, USA

2:45-3:05 PM Unexpected survival of hereditary autonomic disorders Alejandra Gonzalez-Duarte, M.D., Ph.D. Mexico City, Mexico

3:05-3:25 PM GBA in synucleinopathies - from basic science to clinical trials Ziv Gan-Or, M.D., Ph.D. Montreal, Canada

3:25-3:45 PM Genetic associations around the synuclein gene Owen A. Ross, Ph.D. Rochester, MN, USA

3:45-3:55 PM Q&A 3:55-4:05 PM Eastern

Break

Virtual Guided Tours of Posters – Session A 4:05-5:05 PM Eastern Parallel session 4:05-4:35 PM Tour posters with Dr. Vernino 4:35-5:05 PM Tour posters with Dr. Claydon & Dr. Medow Virtual Guided Tours of Posters – Session B 4:05-5:05 PM Eastern Parallel session 4:05-4:35 PM Tour posters with Dr. Raj 4:35-5:05 PM Tour posters with Dr. Singer & Dr. Shibao 5:05-5:15 PM Eastern

Break

5:15-6:00 PM Eastern

Bonus Content: Industry-sponsored symposium

FRIDAY, NOVEMBER 5, 2021

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10:00-10:30 Eastern

Bonus Content: Mindful Meditation (with Mastermind)

10:30-10:45 AM Eastern

Recognition of Fellows of the American Autonomic Society

10:45-11:00 AM Eastern

AAS Business Meeting

11:00-11:10 AM Eastern

Break

11:10-12:10 PM Eastern

Plenary Lecture 2: Hot Topic Plenary Lecture A bionic era in medicine Julian Paton, Ph.D. Auckland, New Zealand Chairs: Wolfgang Singer and Amanda Miller

12:10-12:20 PM Eastern

Break

Debate: Canadian Cardiovascular Society POTS & OI Position Statement: Friend or Foe? Chairs: Satish Raj and Mohammed Numan 12:20-1:50 PM Eastern 12:20-12:25 PM Introduction 12:25-12:40 PM Novel ecosystem of orthostatic intolerance

Juan Guzman, M.D. Hamilton, ON, Canada

12:40-12:55 PM POTS criteria: how to measure heart rate and blood pressure Ronald Schondorf, Ph.D., M.D. Montreal, QC, Canada

12:55-1:00 PM Q&A 1:00-1:15 PM PRO - This statement will help me to care for patients

Howard Snapper, M.D. Marietta, GA, USA

1:15-1:30 PM CON - This statement will cause confusion and delay Wolfgang Singer, M.D. Rochester, MN, USA

1:30-1:35 PM Rebuttal - CON - Howard Snapper 1:35-1:40 PM Rebuttal – PRO - Wolfgang Singer 1:40-1:50 PM Q&A 1:50-2:10 PM Eastern

Break

Session 3: Postural Orthostatic Tachycardia Syndrome Chairs: Mohammed Numan and Meredith Bryarly 2:10-3:40 PM Eastern Parallel session 2:10-2:25 PM Streeten Award: Adrenergic receptor autoantibody concentrations are not different

between patients with postural orthostatic tachycardia syndrome and healthy controls J. Hall, K.M. Bourne, S. Vernino, V. Hamrefors, I. Kharraziha, J. Nilsson, A. Fedorowski, S.R. Raj Calgary, AB, Canada (Poster 124)

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2:25-2:40 PM Vagal stimulation combined with pyridostigmine reduces TNF levels in POTS E. Smith, V. Urechie, L. Okamoto, I. Biaggioni, A. Diedrich

Nashville, TN, USA (Poster 126)

2:40-2:55 PM Short-chain fatty acids and gut microbiome in postural tachycardia syndrome M. Saleem, J.A. Ishimwe, A. Kirabo, C.A. Shibao Nashville, TN, USA (Poster 127)

2:55-3:10 PM FMS/Penaz Wesseling Award: Symptoms and autonomic changes induced by chronic transcutaneous vagus nerve stimulation in hyperadrenergic postural orthostatic tachycardia syndrome D. Shiffer, F. Barbic, S. Rigo, M. Minonzio, A.R. Zamuner, B. Cairo, A. Porta, E. Tobaldini, L. Furlan, N. Montano, V. Ulrechie, I. Biaggioni, A. Diedrich, R. Furlan Rozzano, Italy (Poster 121)

3:10-3:25 PM FMS/Penaz Wesseling Award: Body compression reduces upright blood pressure oscillations in patients with postural orthostatic tachycardia syndrome K.M. Bourne, M.L. Lloyd, J. Baker, J. Hall, R.S. Sheldon, D.V. Exner, J.V. Tyberg, S.R. Raj Calgary, AB, Canada (Poster 128)

3:25-3:40 PM Report on the progress of the iSTAND study, a randomized controlled trial of intravenous immunoglobulin for autoimmune neuropathic postural orthostatic tachycardia syndrome S. Vernino, L.E. Stiles, S. Hopkins, L. Phillips, E. Golden, M. Bryarly Dallas, TX, USA (Poster 112)

Session 4: Basic Science Chairs: Rasna Sabharwal and Amy Arnold 2:10-3:25 PM Eastern Parallel session 2:10-2:25 PM Best Basic Science Autonomic Research Award: Circadian cycle exaggerates

sympathoexcitatory responses to activation of chemosensitive renal sensory nerves L.J. DeLalio, S.D. Stocker

Pittsburgh, PA, USA (Poster 24)

2:25-2:40 PM Both dietary salt restriction and high salt intake exaggerate sympathetic reflexes and sensitive central autonomic networks: potential mechanisms of the J-shaped curve S.D. Stocker, M.M. Wenner, W.B. Farquhar Pittsburgh, PA, USA (Poster 26)

2:40-2:55 PM Immunization of mice with α3 nicotinic acetylcholine receptor induces autonomic dysfunction S. Nakane, M. Yamakawa, N. Tawara, K. Takamatsu, A. Mukaino, K. Nakahara, S. Yamashita, K. Kimura, M. Ueda

Kumamoto, Japan (Poster 22)

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2:55-3:10 PM The role played by ASIC1a in the exercise pressor reflex in rats with heart failure A.L.E. Butenas, K.S. Rollins, A.C. Williams, S.K. Parr, S.T. Hammond, C.J. Ade, K.S. Hageman, T.I. Musch, S.W. Copp Manhattan, KS, USA (Poster 23)

3:10-3:25 PM Augmented T cell mitochondrial reactive oxygen species in adults with major depressive disorder: potential neural-immune interaction A.K. Grotle, A.M. Darling, E.F.H. Saunders, P.J. Fadel, J.L. Greaney, D.W. Trott Arlington, TX, USA (Poster 30)

3:40-3:50 PM Eastern

Break

Virtual Poster Session 3:50-4:50 PM Eastern 3:50-4:20 PM Interact with Poster Presenters (Odd) 4:20-4:50 PM Interact with Poster Presenters (Even) 4:50-5:00 PM Eastern

Break

5:00-5:45 PM Eastern

Bonus Content: Industry-sponsored symposium

5:45-5:55 PM Eastern

Break

5:55-6:55 PM Eastern

Bonus Content: President’s Virtual Reception (with Liquid Lab virtual mixology)

SATURDAY, NOVEMBER 6, 2021 9:30-10:30 AM Eastern

Bonus Content: Industry-sponsored symposium

10:30-10:40 AM Eastern

Break

10:40-11:40 Eastern

Plenary Lecture 3: MSA Plenary Lecture Imaging methods for MSA Daniel Claassen, M.D., M.D. Nashville, TN, USA Chairs: Steven Vernino and Jacquie Baker

11:40-11:50 AM Eastern

Break

Session 5: Multiple System Atrophy Sponsored by The Multiple System Atrophy Coalition Chairs: Amanda Peltier and Sri Muppidi 11:50 AM-12:50 PM Eastern 11:50-12:05 PM Don Summers Memorial MSA Award: Cardiac 18F-Dopamine PET distinguishes

PD with orthostatic hypotension from parkinsonian MSA A. Lenka, G. Lamotte, D.S. Goldstein

Washington, DC, USA (Poster 1)

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12:05-12:20 PM Alpha-synuclein oligomers and neurofilament light chain predict phenoconversion of pure autonomic failure W. Singer, A.M. Schmeichel, M. Shahnawaz, J.D. Schmelzer, D.M. Sletten, T.L. Gehrking, J.A. Gehrking, M.D. Suarez, P.P. Misra, C. Soto, P.A. Low Rochester, MN, USA (Poster 13)

12:20-12:35 PM α-Synuclein deposition in sympathetic nerve fibers in genetic forms of Parkinson’s disease R. Isonaka, D.S. Goldstein, D. Ehrlich, D.P. Narendra Bethesda, MD, USA (Poster 8)

12:35-12:50 PM Differential abnormalities of cerebrospinal fluid dopaminergic vs. noradrenergic indices in synucleinopathies D.S. Goldstein, P. Sullivan, C. Holmes, G. Lamotte, A. Lenka, Y. Sharabi Bethesda, MD, USA (Poster 11)

12:50-1:10 PM Eastern

Break

Session 6: Clinical Trials Chairs: Steven Vernino and Mitch Miglis 1:10-2:40 PM Eastern 1:10-1:25 PM Midodrine for the prevention of vasovagal syncope

R. Sheldon, P. Faris, A. Tang, F. Ayala-Paredes, J. Guzman, M. Marquez, C. Morillo, A. Krahn, T. Kus, D. Ritchie, S. Safdar, C. Maxey, S.R. Raj; for the POST 4 investigators Calgary, AB, Canada (Poster 92)

1:25-1:40 PM Exaggerated postural sway improves orthostatic cardiovascular and cerebrovascular control E.L. Williams, B.C.D. Hockin, N.D. Heeney, K. Elabd, H. Chong, A. Blaber, S.N. Robinovitch, I.T. Parsons, V.E. Claydon Burnaby, BC, Canada (Poster 94)

1:40-1:55 PM Late-breaking clinical trials 1:55-2:10 PM Late-breaking clinical trials 2:10-2:40 PM Poster award winners (4 x 5 min oral presentations) 2:40-2:50 PM Eastern

Break

Interactive Clinical Case Presentations: The 4th Ultimate Autonomic Challenge Chairs: Juan Guzman and Steven Vernino 2:50-3:50 PM Eastern 2:50-2:55 PM Introduction

Juan Guzman, M.D. Hamilton, ON, Canada

2:55-3:05 PM Clinical Case 1 Title Name City, Country

3:05-3:10 PM Q&A

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3:10-3:20 PM Clinical Case 2 Title Name City, Country

3:20-3:25 PM Q&A 3:25-3:35 PM Clinical Case 3

Title Name City, Country

3:35-3:40 PM Q&A 3:40-3:50 PM Open Mic and Closing Remarks 3:50-4:00 PM Closing Remarks

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Accreditation and Credit Designation Statements This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education through the joint providership of The University of Texas Southwestern Medical Center and the American Autonomic Society. The University of Texas Southwestern Medical Center is accredited by the ACCME to provide continuing medical education for physicians. The University of Texas Southwestern Medical Center designates this live activity for a maximum of 11.0 AMA PRA Category 1 Credit(s)TM. Physicians should only claim credit commensurate with the extent of their participation in the activity.

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AAS VIRTUAL POSTER SESSION AND TRAINEE POSTER COMPETITION* FRIDAY, NOVEMBER 5, 2021 *Posters with asterisks are included in the Trainee Poster Competition AUTONOMIC FAILURE: PAF, MSA, PARKINSON’S DISEASE Poster #1 Cardiac 18F-Dopamine PET distinguishes PD with orthostatic hypotension

from parkinsonian MSA A. Lenka, G. Lamotte, D.S. Goldstein

Washington, DC, USA Poster #2 Autonomic disturbances predict concurrent and future mood symptoms in

Parkinson’s disease O. Buron, R. Schondorf, C. Xia Montreal, QC, Canada

Poster #3 Probable ‘premotor’ multiple system atrophy-cerebellar form R. Sakakibara, J.N. Panicker, Y. Aiba, F. Tateno, T. Yamamoto, T. Uchiyama, T. Yamanishi, C. Shibata, S. Simeoni Sakura, Japan

Poster #4* Effects of orthostatic changes and dopaminergic state on cerebral autonomic processing in Parkinson disease, as measured by the heartbeat evoked potential P.A. Beach Atlanta, GA, USA

Poster #5 The synuclein-one study protocol: the optimization of diagnostic confirmation of synucleinopathies C.H. Gibbons, B. Bellaire, R. Freeman, C.H. Adler, D. Moore, T. Levine

Boston, MA, USA Poster #6 Effect of automated mechanical peripheral stimulation on 24-h blood pressure

in a non-dipper patient with Parkinson’s disease: a case study V.H. Vásquez-Fuentes, S.M. Peredo-Millacura, C.F. Peredo-Veliz, F. Barbic, M. Minonzio, D. Shiffer, R. Furlan, A.R. Zamunér Maule, Chile

Poster #7 Responsiveness of UMSARS and other clinical measures in a longitudinal structured care clinic for multiple system atrophy E.P. Golden, M. McCreary, S. Vernino Dallas, TX, USA

Poster #8 α-Synuclein deposition in sympathetic nerve fibers in genetic forms of Parkinson’s disease R. Isonaka, D.S. Goldstein, D. Ehrlich, D.P. Narendra Bethesda, MD, USA

Poster #9* Differences among genetic forms of Parkinson’s disease in baroreflex-sympathoneural function and cardiac noradrenergic innervation R. Isonaka, D.P. Narendra, D.S. Goldstein Bethesda, MD, USA

Poster #10 Biomarkers of central and cardiac catecholamine deficiency predict Parkinson’s disease in at-risk individuals D.S. Goldstein, C. Holmes, J. Gelsomino, J. Cherup, G. Lopez, Y. Sharabi Bethesda, MD, USA

Poster #11 Differential abnormalities of cerebrospinal fluid dopaminergic vs. noradrenergic indices in synucleinopathies D.S. Goldstein, P. Sullivan, C. Holmes, G. Lamotte, A. Lenka, Y. Sharabi

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Bethesda, MD, USA Poster #12 Detection of the autotoxic catecholaldehyde DOPEGAL in pure autonomic

failure D.S. Goldstein, R. Isonaka, P. Sullivan Bethesda, MD, USA

Poster #13 Alpha-synuclein oligomers and neurofilament light chain predict phenoconversion of pure autonomic failure W. Singer, A.M. Schmeichel, M. Shahnawaz, J.D. Schmelzer, D.M. Sletten, T.L. Gehrking, J.A. Gehrking, M.D. Suarez, P.P. Misra, C. Soto, P.A. Low Rochester, MN, USA

Poster #14 Correlations between depression and autonomic symptoms in Parkinson’s disease M. Sklerov, E. Dayan, N. Browner, D. Rubinow, F. Frohlich

Chapel Hill, NC, USA AUTONOMIC NEUROPATHIES Poster #15 Clinical presentation and autonomic profile in Ross syndrome

G. Lamotte, P. Sandroni, J.K. Cutsforth-Gregory, S.E. Berini, E.E. Benarroch, K. Shouman, M.L. Mauermann, J. Anderson, P.A. Low, W. Singer, E.A. Coon

Rochester, MN, USA Poster #16 Intersection of two syndromes: Sjögren syndrome and POTS

B.P. Goodman, L.A. Pace, J. Hemp, M.F. Grill, J.A. Khoury Salt Lake City, UT, USA

Poster #17 Hereditary ATTR amyloidosis presenting with exercise-induced hypotension E.P. Golden, J. Grodin, H. Williams, B. Levine Dallas, TX, USA

Poster #18 Small fiber neuropathy in the Arizona Neuromuscular Unblinded Investigational Study (ANUBIS): evaluation of 1001 consecutive patients B.E. Smith, A.M. Joseph Scottsdale, AZ, USA

Poster #19 Neurophysiologic manifestations of wild type transthyretin amyloidosis M.E. Christiansen, B.P. Goodman, J.L. Rosenthal, M.R. Buras, J.A. Khoury Scottsdale, AZ, USA

Poster #20* Orthostatic intolerance after bariatric surgery: mechanistic insights S.Y. Paranjape, S. Takkouche, A. Diedrich, V. Ulriche, S. Scudder, C.A. Shibao Nashville, TN, USA

AUTONOMIC REGULATION: BASIC SCIENCE & ANIMAL STUDIES Poster #22 Immunization of mice with α3 nicotinic acetylcholine receptor induces

autonomic dysfunction S. Nakane, M. Yamakawa, N. Tawara, K. Takamatsu, A. Mukaino, K. Nakahara, S. Yamashita, K. Kimura, M. Ueda

Kumamoto, Japan Poster #23 The role played by ASIC1a in the exercise pressor reflex in rats with heart

failure A.L.E. Butenas, K.S. Rollins, A.C. Williams, S.K. Parr, S.T. Hammond, C.J. Ade, K.S. Hageman, T.I. Musch, S.W. Copp Manhattan, KS, USA

Poster #24 Circadian cycle exaggerates sympathoexcitatory responses to activation of chemosensitive renal sensory nerves L.J. DeLalio, S.D. Stocker

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Pittsburgh, PA, USA Poster #25* Cardiovascular deconditioning induces plasticity in GABAergic

neurotransmission in the nucleus tractus solitarii L. Lima-Silveira, E.M. Hasser, D.D. Kline Columbia, MO, USA

Poster #26 Both dietary salt restriction and high salt intake exaggerate sympathetic reflexes and sensitive central autonomic networks: potential mechanisms of the J-shaped curve S.D. Stocker, M.M. Wenner, W.B. Farquhar Pittsburgh, PA, USA

Poster #27* Exposure to a high-fat diet rich in linoleic acid exaggerates viscerosensory-sympathetic reflexes in spinalized animals via a TRPV1-dependent mechanism Z. Minic, T. Azar, D.S. O’Leary, C.A. Reynolds

Detroit, MI, USA CARDIOVASCULAR DISEASE, HYPERTENSION, OBESITY & AGING Poster #28 Orthostatic tolerance before and after 60 days of strict head down tilt bedrest

with and without daily artificial gravity training J. Hoenemann, F. Hoffmann, S. Moestl, K. Heusser, E. Mulder, A.E. van Herwaarden, S.M.C. Lee, J. Jordan, J. Tank Cologne, Germany

Poster #29 Association between social jetlag and blood pressure in patients with hypertension N. Covassin, A.B. Danyluk, M.A. Pfeifer, S.S. Munir, J. Bukartyk, V.K. Somers Rochester, MN, USA WITHDRAWN

Poster #30 Augmented T cell mitochondrial reactive oxygen species in adults with major depressive disorder: potential neural-immune interaction A.K. Grotle, A.M. Darling, E.F.H. Saunders, P.J. Fadel, J.L. Greaney, D.W. Trott Arlington, TX, USA

Poster #31 Influence of menopause age on heart rate variability C.T. Tahsin, N. Panigrahy, W. Stokes, A. Glazos, E. Lee, M.L. Vanden Noven, J.R. Carter, M.L. Keller-Ross Minneapolis, MN, USA

Poster #32 Effect of nitroglycerin and sympathetic withdrawal on splanchnic capacitance and cardiac blood volumes L.E. Okamoto, W.D. Dupont, S.Y. Paranjape, J.E. Celedonio, E.C. Smith, M.W. Kronenberg, I. Biaggioni Nashville, TN, USA

Poster #33* Reduced baroreflex sensitivity in men with low testosterone – insight from the Valsalva maneuver M.C. Babcock, L.E. DuBose, K.L. Hildreth, W.K. Cornwell III, K.L. Moreau Aurora, CO, USA

Poster #34* Morning cardiovascular reactivity after evening binge alcohol consumption: sex differences I.M. Greenlund, J.A. Bigalke, A.L. Tikkanen, J.R. Nicevski, C.A. Smoot, J.J. Durocher, J.R. Carter Bozeman, MT, USA

Poster #35 Exaggerated sympathetic neural responses to the cold pressor test in heart failure with preserved ejection fraction

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R. Takeda, S.L. Hissen, S.W. Holwerda, J.P. MacNamara, S. Sarma, P.J. Fadel, B.D. Levine, Q. Fu

Dallas, TX, USA COVID & POST-COVID AUTONOMIC DISORDERS Poster #36 Autonomic dysfunction following COVID-19 infection: an early experience

K. Shouman, G. Vanichkachorn, W.P. Cheshire, M.D. Suarez, S. Shelly, G.J. Lamotte, P. Sandroni, E.E. Benarroch, S.E. Berini, J.K. Cutsforth-Gregory, E.A. Coon, M.L. Mauermann, P.A. Low, W. Singer

Rochester, MN, USA Poster #37 Post-acute COVID-19 autonomic neuropathy: a case report

C.V. San Luis, S.P. Agnihotri, M. Kazamel Birmingham, AL, USA

Poster #38 Moderate to severe autonomic dysfunction is common in post-acute COVID syndrome L.E. Stiles, C.T. Tsui, N. Larsen, L. Schneider, R. Shaik, S. Muppidi, M.G. Miglis

Stony Brook, NY, USA Poster #39 Dysautonomia symptoms in post-acute COVID-19 patients after hospital

discharge: one-month follow-up S. Rigo, F. Barbic, M. Minonzio, G. Putti, A. Bisoglio, M.A. Romeo, F. Pellizon, S. Kulangarathottiyil, L. Bresciani, P. Verzeletti, F. Badilini, M. Ciccarelli, M.G. Bordoni, R. Furlan Milan, Italy

Poster #40 Sympathoadrenal imbalance associated with tilt-evoked sudden hypotension in post-acute SARS-CoV2 A. Lenka, P. Sullivan, D.S. Goldstein; and the NINDS PASC study group Bethesda, MD, USA

Poster #41 Understanding cardiovascular symptoms during recovery from Covid-19 F. McGrew, D. Turner, B. Dragutsky, L. Jackson, A. Worthington Germantown, TN, USA

Poster #42 COVID-19 associated dysautonomia, Mayo Clinic Arizona experience M.F. Grill, J.A. Khoury, B.P. Goodman Scottsdale, AZ, USA

Poster #43* Autonomic dysfunction following acute COVID-19: a series of 3 cases M.E. Briseño-Godínez, R.X. Domínguez-Vega, K. Cárdenas-Soto, A. González-Duarte Mexico City, Mexico

Poster #44 Post-COVID POTS – experience in a single tertiary care center K. Tarpara, M. Bryarly, J. Cabrera, S. Vernino Dallas, TX, USA

EDUCATION Poster #45 Teaching autonomic disorders to neurology trainees: a single-center

experience E. Coon, R. Mustafa, D. Abarbanel, P. Sandroni, L.K. Jones Jr., J.K. Cutsforth-Gregory Rochester, MN, USA

Poster #46 Online case-based medical education program identifies differential practice gaps among neurologists and cardiologists in assessment and management of neurogenic orthostatic hypotension T. Finnegan, J. Maeglin, L. Arnaud-Hevi, S.R. Raj

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Calgary, AB, Canada EXERCISE, TEMPERATURE REGULATION & HYPOXIA Poster #47 Anhidrosis due to topiramate contributing to persistent fever in a critically ill

patient P. Millar Vernetti, H. Kaufmann New York, NY, USA

Poster #48 Effects of a cool classroom microclimate on cognitive performances and cardiac autonomic control in undergraduate students F. Barbic, M. Minonzio, B. Cairo, D. Shiffer, L. Cerina, P. Verzeletti, F. Badilini, M. Vaglio, A. Porta, M. Santambrogio, R. Gatti, S. Rigo, A. Bisoglio, R. Furlan Milan, Italy

Poster #49* Effect of altitude on retinal vascular perfusion density and retinal thickness J. Baker, M.A. Safarzadeh, A.V. Incognito, N.G. Jendzjowsky, C. Braun, B. Herrington, J.K. Leacy, D. Burns, K.D. O’Hallaron, S.R. Raj, T.A. Day, R.J.A. Wilson

Calgary, AB, Canada Poster #50 Role of endothelin-1 on the sympathetic and hemodynamic response to acute

intermittent hypoxia in men J.K. Limberg, S.E. Baker, D.W. Jacob, E.P. Ott, Z.M. Scruggs, J.L. Harper, C.M. Manrique-Acevedo Columbia, MO, USA

Poster #51 An automated non-invasive approach to investigating the intrinsic vascular regulation using functional optical coherence tomography (fOCT) M.A. Safarzadeh, J. Baker, A.V. Incognito, N.G. Jendzjowsky, T.A. Day, U. Alim, R.J.A. Wilson

Calgary, AB, Canada Poster #52 Modulation of cardiovascular response during graded activation of muscle

metabolic reflex E. Khandelwal, S. Tripathi Raipur, India

GENETIC AUTONOMIC DISORDERS Poster #53 Neurofilament light chain (NfL) as a potential biomarker of treatment response

in hereditary transthyretin-mediated amyloidosis: data from the patisiran global OLE study M. Polydefkis, S. Ticau, D. Erbe, A. McManus, E. Aldinc, D. Adams, M. Reilly, A. Vaishnaw, P. Nioi Cambridge, MA, USA

Poster #54* Autonomic and quality of life assessments in patients with TTR mutations after treatment with patisiran vs. placebo K. Cárdenas-Soto, S. Pérez-Castañeda, Y. Morato-Valderrama, A. González-Duarte Mexico City, Mexico

Poster #55* Autonomic failure associated with 16p11.2 gene duplication M. Beeler, G.A. Cook Jr. Bethesda, MD, USA

HUMAN AUTONOMIC PHYSIOLOGY Poster #56 Cardiovascular autonomic functions of gas station attendants in Sri Lanka

T. Warnakulasuriya, K. Medagoda, D. Kottahachchi, D. Luke, D. Wadasinghe, D. De Silva, J. Ariyawansha, P. Rathnayaka, T. Dissanayaka, S. Fernando, N.M. Devanarayana

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Kelaniya, Sri Lanka Poster #57* Heart rate variability among gas station attendants exposed to benzene,

toluene, and xylenes (BTX) in Sri Lanka T. Warnakulasuriya, K. Medagoda, D. Kottahachchi, D. Luke, D. Wadasinghe, D. De Silva, J. Ariyawansha, P. Rathnayaka, T. Dissanayaka, S. Fernando, N.M. Devanarayana, P.T.J. Scheepers Kelaniya, Sri Lanka

Poster #58 Properties of three common time domain indices of heart rate variability: effects of detrending J.F. Thayer, D.P. Williams, M.P. Tarvainen, J. Koenig Irvine, CA, USA

Poster #59 Cardiac and respiratory-related activity recorded from the human vagus nerve V.G. Macefield, M. Patros, M.M. Ottaviani, L. Wright, T. Dawood

Melbourne, Australia Poster #60 Bowel burdens: a systematic review of the impact of bowel dysfunction and

autonomic dysreflexia on quality of life after spinal cord injury E.K. Sober-Williams*, R.H.Y. Lee*, V.E. Claydon

Burnaby, BC, Canada Poster #61 Effects of chronic pelvic pain on ambulatory heart rate variability in women

D.P. Williams, C.R. Wiley, M. Merritt, P. Simpson, L. Conant, F. Tu, J. Janata, G. Chelimsky, J.F. Thayer, T. Chelimsky Irvine, CA, USA

Poster #62 Short-term hypercaloric diet decreases hypothalamic and brainstem functional connectivity in humans D.A. Gerlach, J. Manuel, A. Ewald, A. Hoff, R. De Gioannis, M. Heer, J. Tank, J. Jordan Cologne, Germany

Poster #63* The effect of low dose morphine on cardiovascular responses during simulated hemorrhage in humans J.C. Watso, F.A. Cimino III, L.N. Belval, M. Huang, J.M. Hendrix, B.D. Orth, C. Hinojosa-Laborde, C.G. Crandall Dallas, TX, USA

Poster #66* Direct electrical stimulation of prefrontal cortex attenuates the transient tachycardia response to exercise in conscious humans B. Kulas, M. Arévalo-Astrada, G. Gilmore, A. Suller-Marti, E. Paredes-Aragon, M.-L. Jones, S.M. Mirsattari, J.K. Shoemaker

London, ON, Canada Poster #67 Transcranial alternating current stimulation of the dorsolateral prefrontal cortex

modulates skin sympathetic nerve activity R. Wong, J. Sesa-Ashton, S. Datta, B. McCarthy, V. Macefield, T. Dawood Melbourne, Australia

Poster #68 Hyperhidrosis in men with obstructive sleep apnea: Chilean sleep laboratory experience J. Idiaquez, J.C. Casar, J. Santin, R. Iturriaga Santiago, Chile

Poster #69 Sympathetic transduction to blood pressure in young women using hormonal contraceptives S.J. McGinty, M.M. Wenner, J.L. Greaney Newark, DE, USA

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Poster #70 Assessing vasomotor reactivity in patients with terminal heart failure after heart transplantation by contactless optical occlusive plethysmography O.V. Mamontov, V.V. Zaytsev, A.A. Kamshilin, E.V. Shlyakhto

Saint Petersburg, Russia Poster #71 Computational modeling reveals triphasic progression of Lewy body diseases

D.S. Goldstein, M. Pekker, R. Isonaka, P. Sullivan, Y. Sharabi Bethesda, MD, USA

Poster #72 Actigraphy-based total sleep time is not associated with muscle sympathetic nerve activity in healthy adults J.R. Nicevski, E.M. Kerkering, J.A. Bigalke, I.M. Greenlund, A.L. Tikkanen, J.R. Carter

Bozeman, MT, USA Poster #73 Autonomic dysfunction in Ehlers-Danlos syndrome: how do microcirculatory

and sensory profiles contribute? J. Gierthmühlen, J. Forstenpointner, R. Baron Kiel, Germany

Poster #74 Transcutaneous vagus nerve stimulation for enhancing autonomic function: optimizing stimulation parameters C.E. Taylor, X. Punzalan, V.G. Macefield, A. Burton Sydney, Australia

Poster #75 Insomnia symptom severity is associated with increased muscle sympathetic nerve activity in chronic insomnia J.A. Bigalke, I.M. Greenlund, A.L. Tikkanen, J.R. Nicevski, L. Medalie, B. Mokhlesi, J.R. Carter

Bozeman, MT, USA Poster #78 Autonomic testing in paragangliomas of the head and neck

R.X. Domínguez-Vega, M.E. Briseño-Godínez, K. Cárdenas-Soto, S. Mier y Terán, A. González-Duarte Mexico City, Mexico

Poster #79 Human dorsal root ganglion stimulation reduces sympathetic outflow and long-term blood pressure Y.B. Sverrisdottir, S.C. Martin, G. Hadjipavlou, A.R. Kent, D.J. Paterson, J.J. Fitzgerald, A.L. Green

Oxford, UK Poster #80 An intelligent lower body negative pressure platform to simulate orthostatic

challenge T. Lam, L. Molina, N. Meulenbroek, M. Tso, K.A. Larkin-Kaiser, J. Squair, A. Phillips Calgary, AB, Canada

NOVEL THERAPIES & CLINICAL TREATMENT TRIALS Poster #81 HELIOS-A: 9-month results from the Phase 3 study of vutrisiran in patients with

hereditary transthyretin-mediated amyloidosis with polyneuropathy D. Adams, I.L. Tournev, M.S. Taylor, T. Coelho, V. Plante-Bordeneuve, J.L. Berk, A. González-Duarte, J.D. Gillmore, S.-C. Low, Y. Sekijima, L. Obici, R. Blakesley, S. Arum, R. Shilling, J. Vest, M. Polydefkis

Mexico City, México Poster #82 Impact of patisiran on activities of daily living and functional status in hATTR

amyloidosis A. Peltier, A. González-Duarte, J. Berk, I. Tournev, T. Yamashita, O.B. Suhr, S. Ajroud-Driss, M. Merkel, H. Lin, C. Hale, D. Adams

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Nashville, TN, USA Poster #83 Rapid innovation in the phase 3 ampreloxetine (TD-9855) clinical program

during the COVID pandemic R. Vickery, H. Kaufmann, C. Shibao, M. Bryarly, S. Hopkins, A. Di Fonzo, M. Saxena, A. Albanese, M. Boczarska-Jedynak, S.R. Raj, L. Norcliffe-Kaufmann, K. Griscik, C. Porter, T. Dinh, R.A. Graham Dublin, Ireland WITHDRAWN

Poster #84 Cardiovascular safety and pharmacokinetics of ATH434, a novel small molecule inhibitor of α-synuclein aggregation, in adults and older adults D. Stamler, M. Bradbury, C. Wong, E. Offman Montreal, QC, Canada

Poster #85 Clinician perceptions on the design of a randomized controlled trial on cardioneuroablation for recurrent vasovagal syncope: results from an international clinician survey B. Vandenberk, S.R. Raj, D.S. Chew, R.S. Sheldon, C.A. Morillo

Calgary, AB, Canada Poster #86 Chewing-induced pressor response in acquired afferent baroreflex failure: a

useful therapeutic intervention P. Millar Vernetti, H. Kaufmann New York, NY, USA

Poster #87* Nociceptor-mediated impairment in spontaneous sympathetic baroreflex sensitivity and the potential for improvement via epidural spinal cord stimulation in chronic low back pain Y. Iwakuma, M.T. Holland, G.L. Pierce, S.W. Holwerda Kansas City, KS, USA

ORTHOSTATIC HYPOTENSION, SUPINE HYPERTENSION & SYNCOPE Poster #88* Natural history and autonomic profile in adults with afferent baroreflex failure

G. Lamotte, E.A. Coon, M.D. Suarez, P. Sandroni, E.E. Benarroch, J.K. Cutsforth-Gregory, M.L. Mauermann, S.E. Berini, K. Shouman, D. Sletten, B.P. Goodman, P.A. Low, W. Singer

Rochester, MN, USA Poster #89* Relevant burden of injuries due to vasovagal syncope

J.G. Jorge, S.R. Raj, R.S. Sheldon Calgary, AB, Canada

Poster #90 Evaluating the impact of syncope and presyncope on quality of life: a systematic review and meta-analysis B.C.D. Hockin, N.D. Heeney, D.G.T. Whitehurst, V.E. Claydon

Burnaby, BC, Canada Poster #91 Quantitative gastrointestinal function and corresponding symptom profiles in

autonomic neuropathy E. Tokita, J. Langford, L. Millsap, L.A. Pace, J. Hemp, M.M. Cortez Salt Lake City, UT, USA

Poster #92 Midodrine for the prevention of vasovagal syncope R. Sheldon, P. Faris, A. Tang, F. Ayala-Paredes, J. Guzman, M. Marquez, C. Morillo, A. Krahn, T. Kus, D. Ritchie, S. Safdar, C. Maxey, S.R. Raj; for the POST 4 investigators Calgary, AB, Canada

Poster #93 Difference in diagnostic approach of syncope does not affect short-term clinical outcome

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E. Galron, O. Kehat, A. Weiss-Meilik, G. Jacob Tel Aviv, Israel

Poster #94 Exaggerated postural sway improves orthostatic cardiovascular and cerebrovascular control E.L. Williams, B.C.D. Hockin, N.D. Heeney, K. Elabd, H. Chong, A. Blaber, S.N. Robinovitch, I.T. Parsons, V.E. Claydon Burnaby, BC, Canada

Poster #95 Effects of short-term hypercaloric nutrition on orthostatic tolerance in healthy individuals: a randomized controlled crossover study R. De Gioannis, A. Ewald, D.A. Gerlach, K. Heusser, F. Hoffmann, P. Frings-Meuthen, M. Heer, J. Tank, J. Jordan Cologne, Germany

Poster #96 One-none-done: is the autonomic nervous system involved in cardiac arrest in the young? F.M. Khan, S. Franciosi, A. Krahn, B. Davies, S. Sanatani, V.E. Claydon

Burnaby, BC, Canada Poster #97 Autonomic dysfunction in the setting of Moyamoya syndrome

C. Nguma, E.P. Golden, S. Vernino Dallas, TX, USA

Poster #98* Factors affecting rehabilitation outcomes in a rehabilitation hospital: the effect of orthostatic hypotension J.-W. Park, L.E. Okamoto, P. Sharma, A. Diedrich, L. Massey, J.S. Johns, I. Biaggioni Nashville, TN, USA

Poster #99* Blunting initial orthostatic hypotension: mechanistic roles of muscle contraction vs. sympathetic activation N.A. Sheikh, S.I. Ranada, M. Lloyd, D. McCarthy, R.S. Sheldon, A.A. Phillips, D.V. Exner, M. Runte, S.R. Raj Calgary, AB, Canada

Poster #100* The patient experience with initial orthostatic hypotension: a qualitative study N.A. Sheikh, S.R. Raj, R.S. Sheldon, A.A. Phillips, D.V. Exner, M. Runté Calgary, AB, Canada

Poster #101 Orthostatic chest pain: a cautionary tale E.P. Golden Dallas, TX, USA

Poster #102 Employment implications and workplace accommodation of chronic syncope in Canada T. Runte, S. Jarvie, D. Porter, M. Runté Calgary, AB, Canada

Poster #103 Swooning and silly: gendering syncope T. Runte, S.R. Raj, R.S. Sheldon, M. Runté Calgary, AB, Canada

PEDIATRIC AUTONOMIC DISORDERS Poster #104 Retrospective case series study of “Slow Sodium” sodium chloride tablets for

orthostatic intolerance and vasovagal syncope in patients under 18 years of age S. Mallya, W.P. Whitehouse Nottingham, UK

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Poster #105 Video-EEG- head-up tilt testing in children: useful in selected cases G. Parker, D. Moor, J. Sanders, J. Murfitt, L. Florence, P. Thakker, W.P. Whitehouse

Nottingham, UK Poster #106 24 hour ambulatory ECG findings in children and adolescents with vasovagal

pre-syncope, syncope, and POTS E. Marriott, X. Zhang, J. Hokanson, K. Maginot Madison, WI, USA

Poster #107 Postural orthostatic tachycardia syndrome (POTS) and neurocardiogenic syncope (NCS) in the young population: are they different physiology? M.T. Numan, H.K. Varner, J.E. Lankford, I.J. Butler Houston, TX, USA

Poster #108* Peripheral skin temperature gradients as a potential biomarker of autonomic dysregulation in congenital central hypoventilation syndrome (CCHS) vs. controls N.B. Menta, F. Longi, M. Winston, C.M. Rand, T.M. Stewart, C.D. Brogadir, A. Zhou, E.C. Dunne, S.C. Gordon, S.F. Vitez, A. Charnay, K. Kelly, C. Coleman, B.J. Scher, S. Rizvydeen, G. Niewijk, J.J. Warner, C. Panicker, D.W. Reed, S.M. Hockney, D.E. Weese-Mayer Chicago, IL, USA

Poster #109 Heart rate variability metrics in congenital central hypoventilation syndrome: effect of PHOX2B genotype/mutation and age I. Khaytin, M. Winston, C.M. Rand, T.M. Stewart, L. Kitsis, K. Reed, N.B. Menta, C.D. Brogadir, S.M. Slattery, D.E. Weese-Mayer Chicago, IL, USA

Poster #110 Autonomic nervous system dysfunction is associated with re-hospitalization in pediatric sepsis survivors C.M. Badke, L. Swigart, D.E. Weese-Mayer, L.N. Sanchez-Pinto Chicago, IL, USA

Poster #111 Evaluation of pupillometry as a measure of autonomic dysfunction in adolescents referred for orthostatic intolerance J.R. Boris, N. Krishnamurthi, C.M. Rand, R. Gonik, M. Winston, T.M. Stewart, L. Kitsis, C.D. Brogadir, I. Khaytin, S.M. Slattery, D.E. Weese-Mayer

Moylan, PA, USA POSTURAL ORTHOSTATIC TACHYCARDIA SYNDROME (POTS) Poster #112 Report on the progress of the iSTAND study, a randomized controlled trial of

intravenous immunoglobulin for autoimmune neuropathic postural orthostatic tachycardia syndrome S. Vernino, L.E. Stiles, S. Hopkins, L. Phillips, E. Golden, M. Bryarly Dallas, TX, USA

Poster #113 Toward a more accurate estimate of the prevalence of postural orthostatic tachycardia syndrome S. Vernino Dallas, TX, USA

Poster #114 Lumping and splitting heart rates in evaluating orthostatic intolerance W.P. Cheshire, D.V. Dudenkov Jacksonville, FL, USA

Poster #115 Nutrient deficiencies and supplementation in postural orthostatic tachycardia syndrome: a systematic review H. Catchpole, M. Sweeney, R. Bonakdar

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La Jolla, CA, USA Poster #116 Cutaneous alpha-synuclein deposition in postural tachycardia patients

T. Levine, B. Bellaire, C. Gibbons, R. Freeman Scottsdale, AZ, USA

Poster #117 Echocardiographic evidence of exercise intolerance in children with POTS – a prospective controlled study: effect of left ventricular mass B. Kakavand, T.M. Maul, P.C. Madueme, J. Cibiras, G. Dadlani Orlando, FL, USA

Poster #118 Echocardiographic evidence of exercise intolerance in children with POTS – a prospective controlled study: effect of cardiac filling during exercise B. Kakavand, T.M. Maul, P.C. Madueme, J. Cibiras, G. Dadlani Orlando, FL, USA

Poster #119* Mycoplasma pneumoniae infection associated with autoimmune small fiber neuropathy and postural orthostatic tachycardia syndrome (POTS) A. Sandefer, K.R. Chémali Norfolk, VA, USA

Poster #120 Respiratory patterns in postural tachycardia syndrome B.P. Goodman, J.A. Khoury, J. Hemp, L.A. Pace Salt Lake City, UT, USA

Poster #121 Symptoms and autonomic changes induced by chronic transcutaneous vagus nerve stimulation in hyperadrenergic postural orthostatic tachycardia syndrome D. Shiffer, F. Barbic, S. Rigo, M. Minonzio, A.R. Zamuner, B. Cairo, A. Porta, E. Tobaldini, L. Furlan, N. Montano, V. Ulrechie, I. Biaggioni, A. Diedrich, R. Furlan Rozzano, Italy

Poster #122* The POTS patient experience in Canada versus the United States J. Hall, K.M. Bourne, L.E. Stiles, R.S. Sheldon, C.A. Shibao, L.E. Okamoto, E.M. Garland, A.C. Gamboa, A. Peltier, A. Diedrich, I. Biaggioni, D. Robertson, S.R. Raj Calgary, AB, Canada

Poster #123* Pediatric POTS: insights from the big POTS survey J. Hall, K.M. Bourne, L.E. Stiles, R.S. Sheldon, C.A. Shibao, L.E. Okamoto, E.M. Garland, A.C. Gamboa, A. Peltier, A. Diedrich, I. Biaggioni, D. Robertson, S.R. Raj Calgary, AB, Canada

Poster #124 Adrenergic receptor autoantibody concentrations are not different between patients with postural orthostatic tachycardia syndrome and healthy controls J. Hall, K.M. Bourne, S. Vernino, V. Hamrefors, I. Kharraziha, J. Nilsson, A. Fedorowski, S.R. Raj Calgary, AB, Canada

Poster #125* Estimation of sleep timing and duration using actigraphy in patients with orthostatic intolerance A.M. Murray, A. Errthum, S. Behl, K. Mara, A. Jones, S. Ahrens, K. Klaas, J. Baughn, P.R. Fischer, R.M. Lloyd Rochester, MN, USA

Poster #126 Vagal stimulation combined with pyridostigmine reduces TNF levels in POTS E. Smith, V. Urechie, L. Okamoto, I. Biaggioni, A. Diedrich

Nashville, TN, USA

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Poster #127 Short-chain fatty acids and gut microbiome in postural tachycardia syndrome M. Saleem, J.A. Ishimwe, A. Kirabo, C.A. Shibao Nashville, TN, USA

Poster #128 Body compression reduces upright blood pressure oscillations in patients with postural orthostatic tachycardia syndrome K.M. Bourne, M.L. Lloyd, J. Baker, J. Hall, R.S. Sheldon, D.V. Exner, J.V. Tyberg, S.R. Raj Calgary, AB, Canada

SPINAL CORD INJURY Poster #129 National survey of mental health and suicidal thoughts in people with spinal

cord injury R.D. Sanguinetti, J.E. Soriano, J.W. Squair, J.J. Cragg, K.A. Larkin-Kaiser, A. McGirr, A.A. Phillips Calgary, AB, Canada

Poster #130* Relationships between cardiovascular disease risk, neuropathic pain, mental health, and autonomic function in chronic SCI M.C. Dorton, J.K. Kramer, S. de Groot, M. Post, V.E. Claydon Burnaby, BC, Canada

Poster #131 Barriers and facilitators to changing bowel care practices after spinal cord injury: a theoretical domains framework approach V.-E.M. Lucci, R.C. McKay, C.B. McBride, M.S. McGrath, R. Willms, H.L. Gainforth, V.E. Claydon

Burnaby, BC, Canada Poster #132* Markers of susceptibility to cardiac arrhythmia in experimental spinal cord

injury and the impact of sympathetic stimulation and exercise training V.-E.M. Lucci, E.L. Harrison, K.M. DeVeau, K.A. Harman, J.W. Squair, A. Krassioukov, D.S.K. Magnuson, C.R. West, V.E. Claydon

Burnaby, BC, Canada Poster #133 Long-term neuroprosthetic hemotherapy treats autonomic dysreflexia after

spinal cord injury J.E. Soriano, R. Hudelle, J.W. Squair, M.A. Anderson, M. Gautier, M. Tso, G. Courtine, A.A. Phillips Calgary, AB, Canada

Poster #134 Spinal cord injury necessitates controlled breathing to index cardiac vagal modulation from respiratory sinus arrhythmia J.A. Taylor, G. Schleifer, R. Solinsky Boston, MA, USA

Poster #135 Transplanting embryonic Raphe nuclei-derived neural stem cells into the injured spinal cord to improve cardiac function S. Fernandes, E. Oatman, S. Hou Philadelphia, PA, USA

Poster #136 Long-term neuroprosthetic hemotherapy prevents aberrant hyperreflexive plasticity after spinal cord injury M.M. Tso, J.E. Soriano, R. Hudelle, J. Squair, M. Anderson, M. Gautier, G. Courtine, A.A. Phillips Calgary, AB, Canada

Poster #138* Orthostatic hypotension is associated with impaired cardiac structure and function after spinal cord injury B.A. Scott, B.D. Hayes, A. Satriano, M. Tso, M.S. Poormasjedi-Meibod, M. Fossey, E. Erskine, J.E. Soriano, R.E. Rosentreter, A. Dufour, R.

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Charbonneau, P. Feuchter, S. Rivest, J. Flewitt, J. Garcia, C. West, J. White, A.A. Phillips

Calgary, AB, Canada Poster #139 Hemodynamic response to exercise interventions in people with chronic

complete spinal cord injury: a systematic literature and meta-analysis N. Mirzadzare*, R.E. Rosentreter*, B. Vaseghi, A. Cote, A. Phillips#, K.A. Larkin-Kaiser#

Calgary, AB, Canada Poster #140 A systematic review of prevalence of cardiovascular disease after spinal cord

injury M. Potemkin, L.E. Crack, K.A. Larkin-Kaiser, A.A. Phillips Calgary, AB, Canada

Poster #141 Self-reported knowledge and symptoms of bone mineral density loss in individuals with spinal cord injury A.K. Wall, L.E. Crack, W.B. Edwards, K.A. Larkin-Kaiser, A.A. Phillips Calgary, AB, Canada

COVID & POST-COVID AUTONOMIC DISORDERS Poster #142 Demonstrating new-onset or worsened sympathetic cholinergic function post

COVID-19 A.V. Varma-Doyle, N. Villemarette-Pittman, P. Lelorier, N. Reeves, J. England Boston, MA, USA