alon kahana, md, phd · rpb physician scientist award pi: alon kahana, md, phd agency: research to...

Kahana, March 2020,

ALON KAHANA, MD, PhD

EDUCATION 5/91 B.A./M.A., Summa cum Laude, With Honors, Brandeis University, Biochemistry, Thesis: “ATP-independent inactivation of rhodopsin in squid photoreceptors.” Advisor: John E. Lisman, Ph.D. 12/98 Ph.D., The University of Chicago, Molecular Genetics & Cell Biology (MSTP) Fred Hutchinson Cancer Research Center, Seattle, WA Thesis: “Investigations of Silencing in Yeast: The Requirement for the Ubiquitin Hydrolase Dot4p in the Regulation of Silencing.” Advisor: Daniel E. Gottschling, Ph.D. 6/01 M.D., With Honors, The University of Chicago Pritzker School of Medicine (MSTP) POSTDOCTORAL TRAINING - CLINICAL 7/01–6/02 Advocate-Illinois Masonic Medical Center, Chicago, Transitional Residency Chief Resident 7/02–6/05 Ophthalmology Residency, University of Wisconsin 7/05–6/07 Oculofacial Plastic and Reconstructive Surgery Fellowship, University of Wisconsin Fellowship Director: Mark J. Lucarelli, M.D. 7/05-6/07 Facial Cosmetic Surgery Fellowship, Madison, Wisconsin Fellowship Director: Bradley N. Lemke, M.D. POSTDOCTORAL TRAINING - RESEARCH 2000–2001 The University of Chicago Research: Effects of high potassium preservation (“Wisconsin”) solution on pancreatic islet cells PI: Louis Philipson, M.D., Ph.D., Department of Medicine, Section of Endocrinology 2004–2007 University of Wisconsin, Madison, WI Research: Regulation of zebrafish orbitofacial development PI: Mary Halloran, Ph.D., Department of Zoology MENTORED RESEARCH TRAINING 2008–2012 University of Michigan, Ann Arbor, MI Mentored Research: Zebrafish models of eye disease Mentor: Daniel Goldman, Ph.D., Department of Biochemistry and the Molecular and Behavioral Neuroscience Institute CERTIFICATION AND LICENSURE 2004 – 2007 Medical license, Wisconsin (#46659) 2006 – Present DEA Registration 2007 – Present Controlled Substance, Michigan (#5315030381) 2007 – Present Medical license, Michigan (#4301089523) 2006 – 2026 Certification, American Board of Ophthalmology (MOC passed, certified through 2026)

Oculoplastic and Orbital Surgery Consultants in Ophthalmic and Facial Plastic Surgery, P.C. Southfield, Michigan

Kahana, March 2020,

ACADEMIC AND CLINICAL APPOINTMENTS 2005 – 2007 Clinical Instructor, Department of Ophthalmology and Visual Sciences, University of Wisconsin 2007 – 2014 Assistant Professor, Department of Ophthalmology and Visual Sciences, University of Michigan Kellogg Eye Center 2014 – 2016 Associate Professor, Department of Ophthalmology and Visual Sciences, University of Michigan Kellogg Eye Center 2012 – 2016 Emerging Scholar, A. Alfred Taubman Medical Research Institute 2016 – 2020 Associate Professor with Tenure, Department of Ophthalmology and Visual Sciences, University of Michigan, Kellogg Eye Center 2007 – 2020 Staff Surgeon, C.S. Mott Children’s Hospital, Ann Arbor, MI 2007 – 2020 Consultant, Veterans Hospital, Ann Arbor, MI 2008 – 2020 Full Member, Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 2010 – 2020 Member, Center for Organogenesis, University of Michigan, Ann Arbor, MI 2012 – 2020 Faculty, Graduate Program in Cellular and Molecular Biology 2016 – 2020 Taubman Scholar, A. Alfred Taubman Medical Research Institute 2018 – 2020 Scholar, Forbes Institute for Cancer Discovery CLINICAL INTERESTS My surgical practice can be divided into five areas of focus: (1) orbital disorders, such as thyroid orbitopathy, vascular anomalies and orbital tumors; (2) pediatric oculoplastic surgery, such as congenital ptosis, blepharophimosis syndrome, coloboma, and congenital anophthalmia; (3) periocular cancer treatment and reconstructive surgery; (4) lacrimal disorders; and (5) eyelid disorders, such as involutional ptosis, ectropion, entropion, facial palsy and eyelid retraction, etc. In all five areas, my practice is distributed evenly between tertiary care referrals and highly complex quaternary care referrals. I perform >700 major surgeries per year, including >175 orbital surgeries. RESEARCH INTERESTS The PI/PD’s funded research encompasses basic, translational, clinical and device research, bringing together multiple forms of healthcare research in an innovative fashion that builds on his training and practice as a surgeon-scientist. The PI/PD is the Lead Investigator of a 5-year investigator-initiated prospective clinical trial (cancer) with significant basic and translational components to assess the utility of hedgehog pathway inhibitors in saving vision in cases of advanced periocular and orbital basal cell carcinoma. The trial brings together clinical, histologic, genomic and molecular marker analysis to develop advanced tools for treating personalized care for locally aggressive basal cell carcinoma. PI/PD’s basic research projects utilize zebrafish to study tumor metastasis and heterogeneity, as well as stem cell reprogramming in an adult zebrafish model. Utilizing zebrafish embryo xenografts, the lab is studying epithelial/mesenchymal transitions during the metastatic process, as well as characterizing signaling and epigenetic pathways that regulate the metastatic process. Ultimately the xenograft model will be used as a tool for drug development targeting the metastatic process. Using a zebrafish adult regeneration model, we are characterizing the biology of cellular reprogramming and dedifferentiation. We find remarkable similarities between genomic reprogramming during tissue regeneration and the behavior of cancer stem cells in oncogenesis. The PI/PD’s translational/pre-clinical research project is focused on the role of nuclear receptors in regulating the inflammatory response of orbital fibroblasts in thyroid eye disease. The PI/PD is also actively involved in device development, with one patent issues and one provisional patent filed, and with Coulter Innovation Program funding for developing and bringing to market a novel lacrimal drainage device. CURRENT AND RECENTLY COMPLETED RESEARCH SUPPORT Title: Vismodegib for Orbital and Periocular Basal Cell Carcinoma (VISORB). ClinicalTrials.gov Identifier: NCT02436408 PI: Alon Kahana, MD, PhD Agency: Genentech, Inc. (with additional support from the UM Comprehensive Cancer Center and the Dept. of Ophthalmology and Visual Sciences) Period: 2015-2020

Kahana, March 2020,

Amount: $850,000 (Genentech, Inc., 29% indirect cost recovery) and $95,315 (University of Michigan) The goal of this investigator-initiated prospective clinical trial, which will be run by the PI through the Clinical Trials Office at the UM Cancer Center, is to characterize the role of hedgehog inhibition in the treatment of periocular basal cell carcinoma. The clinical trial will be accompanied by a translational science investigation of the response of tumors to hedgehog inhibition and analysis of disease predictors, with the goal of improving treatment and identifying new treatment targets. Enrollment began in June 2015. Title: Molecular Pathways of Cancer Cell Stemness and Metastasis PI: Alon Kahana, MD, PhD Forbes Cancer Research Institute Period: 04/01/2018 – 06/30/2020 Amount: $120,000 This project utilizes both human and zebrafish studies to elucidate the molecular mechanisms underlying the metastatic process, using a zebrafish xenograft model of breast cancer as well as chromosome conformation capture (Hi-C) and phenotypic analysis. Title: Molecular Studies of Orbital Inflammation and its Regulation by Retinoic Acid Research Training Grant to Curtis Heisel, MS4 PI: Alon Kahana, MD, PhD Agency: Research to Prevent Blindness, Inc. Period: 12/6/2017 - 04/30/2019 Amount: $30,000 Title: Curing Cancer Through the Therapeutic Targeting of “Stemness” as a Biological State. PI: Alon Kahana, MD, PhD; Max Wicha, MD; Jacqueline Jeruss, MD, PhD; Lonnie Shea, PhD Agency: A. Alfred Taubman Medical Research Institute Period: 4/1/2017 - 12/31/2019 Amount: $500,000 Cancer is a disease of unregulated cell division and migration, which leads to metastasis, organ damage, and the sequelae of malignant tumors (including death). The paradigm that has dominated cancer research over the past 30 years is that cancer is a genetic disease driven by mutations and subsequent selection of malignant cell clones. At the same time, there is growing appreciation that the most important cancer cells harbor unique traits that transcend specific mutations, with features more similar to embryonic stem cells - i.e. cancer stem cells. These are the cells that ultimately metastasize and kill our patients. Our group’s Taubman Grand Challenge Project aims to fight cancer by (1) characterizing key traits of cancer stem cells that can be targeted therapeutically, and (2) developing a unique implantable technology that will attract cancer stem cells during the act of metastasis, providing critical information about these cells, facilitating early detection of metastatic events, and potentially thwarting the metastatic process. Title: Transcriptional Regulation of Muscle Regeneration and Myocyte Dedifferentiation PI: Alon Kahana, MD, PhD A. Alfred Taubman Medical Research Institute Period: 06/01/2018 – 05/31/2019 Amount: $50,000 The goals of this project are to characterize the role of Myc-associated transcriptional factors in the reprogramming of injured myocytes in a zebrafish model. Title: Retinoid-Regulated Expression of Pro-Inflammatory Cytokines in Orbital Tissues: A Potential Common Denominator in Orbital Inflammatory Syndromes. PI: Alon Kahana, MD, PhD Agency: Alliance for Vision Research Period: 4/1/2018 - 6/30/2019 Amount: $8,000

Kahana, March 2020,

The goal of this project is to characterize the role of nuclear receptor ligands in stimulating pro-inflammatory signals in the orbit. MENTORING GRANTS Title: Regulation of Ocular Neural Crest and its Implications in Congenital Eye Disease Role: Mentor PI: Brenda L. Bohnsack, MD, PhD Agency: NIH/NEI K08 EY022912 Period: 12/1/2012 – 11/30/2017 The research goal of this career development mentored research project is to study the biology of the ocular neural crest in a zebrafish model as a means of identifying and characterizing developmental pathways involved in the formation of the anterior segment of the eye, with a focus on congenital glaucoma. This is a mentored clinician-scientist award, and Dr. Kahana provides direct mentoring and material support to the PI. PRIOR GRANT SUPPORT Title: A Zebrafish model of extraocular muscle regeneration. PI: Alon Kahana, MD, PhD Agency: NIH/NEI R01 EY022633 Period: 4/1/2013 – 3/31/2018 Amount: $1,497,000 (incl. indirect cost recovery) The goals of this project are designed to develop a mechanistic understanding of muscle regeneration using zebrafish, and focusing on processes that can serve as potential therapeutic targets, such as regulation of apoptosis, autophagy and extracellular matrix remodeling. Title: Neuronal Remodeling in Strabismus RPB Physician Scientist Award PI: Alon Kahana, MD, PhD Agency: Research to Prevent Blindness Period: 7/1/2014 – 6/30/2017 Amount: $100,000 The goal of this project is to characterize the oculomotor neuronal control circuit in zebrafish in order to develop a model for studying neuronal plasticity following extraocular muscle injury. Title: The role of retinoic acid in regulating thyroid eye disease. PI: Alon Kahana, MD, PhD Agency: Alliance for Vision Research Period: 10/1/2014 – 11/1/2017 The goal of this project is to test the hypothesis that retinoic acid and thyroid hormone interact to regulate orbital cell signaling that may be important in the pathogenesis of thyroid eye disease. Title: Annotating long non coding RNAs (lncRNA) in zebrafish using an adult muscle regeneration model. PI: Alon Kahana, MD, PhD. Co-PIs: Max Wicha, MD, Laura Buttitta, PhD Agency: University of Michigan M-Cubed Seed Grant Period: 1/1/2016 – 12/31/2017 The goal of this project is to utilize the commonalities among zebrafish regeneration, drosophila wing development and human cancer stem cells to annotate genes essential for cellular reprogramming, with particular emphasis on long non-coding RNAs. Title: Lacrimal stent with opening to improve draining efficacy and reduce infection. PI: Alon Kahana, MD, PhD Agency: University of Michigan MTRAC Kickstart Award

Kahana, March 2020,

Period 1/1/2016-12/31/2016 The goal of this clinical project is to test whether use of a newly-invented stent reduces tearing in patients while it stents open their lacrimal system. Through an active collaboration a biomedical engineer, we have now developed a lacrimal stent that has a slit opening strategically located to drain tears into the lumen. Such a stent could revolutionize the use of stents in the treatment of symptomatic, debilitating epiphora. Title: A zebrafish model for studying orbital development and disease. PI: Alon Kahana, MD, PhD Agency: NIH/NEI K08 EY018689 Period: 1/01/2008-12/31/2012 The goals of this mentored career development award are to utilize genetic and biological tools available in zebrafish to shed new light on the genetics and cell biology of orbital neural crest-derived tissues, in order to lead to improved diagnostic and treatment for thyroid eye disease and other orbital diseases. Title: A zebrafish model for studying orbital development and disease. PI: Alon Kahana, MD, PhD Agency: NIH/NEI K08 EY018689-02S109 ARRA administrative supplement Period: 07/01/09 – 12/31/2012 Title: Zebrafish as a model for studying the regulation of extraocular muscle development and organization. PI: Alon Kahana, MD, PhD RPB Career Development Award Agency: Research to Prevent Blindness Period: 07/01/09 – 6/30/13 This career development award provides discretionary funds to investigate the organization and control of extraocular muscle development. Title: Regulation of gene expression during extraocular muscle regeneration in zebrafish. PI: Alon Kahana, MD, PhD and Dan Kasprick Agency: Fight For Sight, Inc. Period: 6/1/10 – 8/31/2010 Title: The role of IGF signaling in zebrafish orbital development and extraocular muscle organization. PIs: Alon Kahana, MD, PhD, and Brenda L. Bohnsack, MD, PhD Agency: Knights Templar Eye Foundation Period: 7/1/10 – 6/30/2011 Title: Helmut F. Stern Career Development Professorship in Ophthalmology and Visual Sciences Period: 7/1/2010 – 6/30/2015 Title: Developing genomic technologies to study extraocular muscle organization and strabismus using a zebrafish model. PIs: Alon Kahana, MD, PhD, and Brenda L. Bohnsack, MD, PhD Agency: Fight For Sight, Inc. Period: 8/1/10 - 7/31/2011 Title: Biological Signals Controlling Extraocular Muscle Regeneration and Repair. PI: Alon Kahana, MD, PhD Agency: Alliance for Vision Research Period: 8/1/2010 – 7/30/2011

Kahana, March 2020,

Title: Investigating the roles of Twist1 and Twist2 in extraocular muscle biology and orbital rhabdomyosarcoma. PI: Alon Kahana, MD, PhD Agency: Alliance for Vision Research Period: 10/1/2011 – 9/30/2012 Title: Thyroid-related eye disease: a preclinical study investigating the role of retinoid receptors in mediating orbitopathy. PI: Alon Kahana, MD, PhD Agency: Alliance for Vision Research Period: 10/1/2011 – 9/30/2012 Title: Chemical genomic screen for modifiers of Axenfeld-Rieger Syndrome: a pilot study to identify novel therapeutics of anterior segment dysgenesis. PI: Alon Kahana, MD, PhD Agency: Alliance for Vision Research Period: 10/1/2011 – 9/30/2012 Title: Investigating the role of extracellular matrix factors and collective cell migration in extraocular muscle repair and regeneration using a zebrafish model. PI: Alon Kahana, MD, PhD Agency: Alliance for Vision Research Period: 10/1/2011 – 9/30/2012 Title: Chemical genomic screen for modifiers of Axenfeld-Rieger Syndrome: a pilot study to identify novel therapeutics of anterior segment dysgenesis. PI: Alon Kahana, MD, PhD Agency: Midwest Eye Bank Period: 6/1/2012 – 5/31/2013 Title: Stem cells in orbital disease and regeneration. PI: Alon Kahana, MD, PhD Agency: Taubman Medical Research Institute, Wm. Davidson Emerging Scholar Fund Period: 07/01/2012 – 06/30/2015 This Emerging Scholar Award, named after Mrs. William Davidson, provides discretionary funds over 3 years to advance the research activities of the PI. This award is being used to study the neurologic response to perturbations in the oculomotor system. The goal is to improve treatment for strabismic conditions, as well as more broadly for systemic neuromuscular disorders. Title: Regulation of extraocular muscle response to injury by autophagy and extracellular matrix remodeling, possible targets for therapy. PI: Alon Kahana, MD, PhD Agency: Alliance for Vision Research Period: 11/1/2012 – 10/31/2013 Title: Investigating the roles of retinoic acid and thyroid hormone in the pathogenesis of thyroid eye disease PI: Alon Kahana, MD, PhD Agency: Alliance for Vision Research Period: 11/1/2012 – 10/31/2013 HONORS AND AWARDS

Kahana, March 2020,

1989 Brandeis Undergraduate Research Award, Brandeis University 1990 Brandeis Scholar Award for distinction in the School of Science, Brandeis University 1990 Nathan & Bertha Richter Science Award, Brandeis University 1990 Doris Brewer Cohen Award for distinction in the School of Science, Brandeis University 1991 Nathan O. Kaplan Award for distinction, Department of Biochemistry, Brandeis University 1991 Dean’s List every semester, Brandeis University 1991 Summa Cum Laude, Brandeis University 1991 Phi Beta Kappa, Brandeis University 1991 Medical Scientist National Research Service Award, MSTP, The University of Chicago 1995 Aging Research Award, Glenn Foundation and the American Federation for Aging Research 2001 The Medical Alumni Prize, The University of Chicago Prizker School of Medicine 2001 Graduation with Honors, The University of Chicago Pritzker School of Medicine 2006 Research Award, Association of University Professors in Ophthalmology (AUPO) 2006 Marvin H. Quickert Thesis Award, ASOPRS 2007 Housestaff Association Excellence Award, University of Wisconsin Hospital 2009 Anthony P. Adamis Prize in Ophthalmology Research, University of Michigan 2010 ARVO/Alcon Early Career Clinician-Scientist Research Award, Alcon 2009-2012 Metro Detroit Top Doctors 2012 Michael Blumenthal Keynote Lecture, Israel Microsurgical Convention, Eilat, Israel 2013 American Academy of Ophthalmology’s Achievement Award 2010-2015 Helmut F. Stern Career Development Professorship in Ophthalmology, University of Michigan 2011-2016 Alliance for Vision Research Award 2014-2016 Physician-Scientist Award, Research to Prevent Blindness 2016 Coulter Award for Medical Innovation 2012–2017 Alfred Taubman Emerging Scholar, Taubman Research Institute, University of Michigan 2017-2020 Alfred Taubman Scholar, Taubman Research Institute, University of Michigan 2008-Present Listed in Who’s Who 2009-Present America’s Best Doctors 2018 Alliance for Vision Research Grant Award MEMBERSHIPS IN PROFESSIONAL SOCIETIES 2002-Present American Academy of Ophthalmology 2002-Present Association for Research in Vision and Ophthalmology 2007-Present American Medical Association 2007-2012 Michigan Society of Eye Physicians & Surgeons 2008-2012 Society for Developmental Biology 2010-2020 Michigan Diabetes Research and Training Center 2008-Present American Society of Ophthalmic Plastic and Reconstructive Surgery 2012-Present The Endocrine Society 2012-Present International Society for the Study of Vascular Anomalies (ISSVA) 2015-Present American Society for Cell Biology 2015-Present American Association for Cancer Research 2016-Present North American Society of Academic Orbital Surgeons (Founding President) 2016-Present International Zebrafish Society 2018-2019 BLiSS ExMC-X Hab, NASA (Medical Advisor) JOURNAL REVIEWER 2005-Present JAMA Ophthalmology 2005-Present Ophthalmology 2005-Present Ophthalmic Plastic and Reconstructive Surgery 2007-Present Investigative Ophthalmology and Visual Sciences 2007-Present Developmental Dynamics

Kahana, March 2020,

2007-Present American Journal of Ophthalmology 2008-Present Developmental Biology 2009-Present PLoS One 2013-Present Stem Cells 2014-Present Science 2015-Present Frontiers in Neuroscience 2015-Present Autophagy DEPARTMENT OF OPHTHALMOLOGY AND VISUAL SCIENCES SERVICE & COMMITTEES 2004-2005 Member, Ophthalmology Residency Curriculum Committee, University of Wisconsin 2007-2008 Member, Departmental Faculty Recruitment Committee, University of Michigan 2008-2011 Departmental Representative, UMHC Cosmetic Surgery Committee Representative 2009-2011 Lead, Clinical Forms Committee, Eye Plastics and Orbital Surgery Service 2009-2012 Member, Electronic Medical Records Committee, Department of Ophthalmology and Visual Sciences, University of Michigan 2010-2013 Member, Clinical Care Committee 2013-2014 Member, Education Committee 2013-2014 Departmental Director of Clinical Fellowship Programs 2013-2015 Vision Seminar Committee 2011-2017 Director, Multiphoton Microscopy Facility 2016-2018 Department of Ophthalmology “Think Tank” Strategic Innovation Committee 2016-2019 Department of Ophthalmology Awards Committee 2017-2019 Department of Ophthalmology Strategic Recruitment Committee 2013-2020 Director, Laser Microdissection Shared Facility 2017-2020 Director of Physician Assistant Program, University of Michigan Kellogg Eye Center 2019-Present Board Member, University of Wisconsin Ophthalmology Alumni Association NATIONAL AND INTERNATIONAL COMMITTEES AND SERVICE ORGANIZATIONS 1987-1991 Companion to Elders, The Waltham Group. Assisted an elderly man with Parkinson's disease. Waltham, MA 1990-1991 Brandeis University Presidential Search Committee Member, Waltham, MA 1991-1995 MSTP Class President, The University of Chicago 1993-1999 Pritzker Admissions Interviewer, The University of Chicago 1994-1995 Graduate Student Recruitment, Student Committee Leader, The University of Chicago 1994-1995 Molecular Genetics Departmental Retreat Organizer, The University of Chicago 1995-1996 The University of Chicago's Maroon Newspaper Opinion Column Writer 1998-1999 Adolescent Substance Abuse Prevention (ASAP) Program Volunteer, Chicago, IL 1998-1999 Maria Shelter for Women, Health and Education Program Volunteer, Chicago, IL 2001 Member, Institutional Review Committee, Department of Medicine Residency Program, Advocate-Illinois Masonic Medical Center, Chicago, IL 2001-2002 Member, Educational Review Board, Advocate-Illinois Masonic Medical Center 2004-2005 Member, Ophthalmology Residency Curriculum Committee, University of Wisconsin. 2006-2010 International Thyroid Eye Disease Society (ITEDS) 2002-Present Association for Vision in Research and Ophthalmology (ARVO) 2002-Present American Academy of Ophthalmology (AAO) 2007-Present Instructor, AAO Skills Transfer Course - Anatomic Foundation of Oculoplastic Surgery 2007-Present Society for Developmental Biology (SDB) 2007-Present American Society of Ophthalmic Plastic and Reconstructive Surgery (ASOPRS) 2007-Present Michigan Society of Eye Physicians and Surgeons (MiSEPS) 2007-2012 American Medical Association (AMA) 2009, 2012 Moderator, ASOPRS Annual Meeting 2010 Moderator, ARVO Annual Meeting

Kahana, March 2020,

2013 American Society of Ophthalmic Plastic and Reconstructive Surgery (ASOPRS) Nominating Committee

2011-2015 American Academy of Ophthalmology (AAO) Basic and Clinical Science Course (BCSC) Fundamentals and Principles of Ophthalmology Revision Committee

2015-2020 Member, Thesis Review Committee, American Society of Ophthalmic Plastic and Reconstructive Surgery (ASOPRS) (Committee Chairmanship in 2019)

2012-Present International Society for the Study of Vascular Anomalies (ISSVA) 2015-Present Scientific Review Board, Alliance for Vision Research. 2016-Present Founding President, North American Society of Academic Orbital Surgeons (NASAOS) 2017-Present Chair, Scientific Advisory Committee, American Society of Ophthalmic Plastic and Reconstructive

Surgery (ASOPRS) 2018-Present Program Director, Oculofacial Plastic and Reconstructive Surgery Fellowship, American Society of

Ophthalmic Plastic and Reconstructive Surgery (ASOPRS) PATENTS AND INVENTIONS 1998 “Monoclonal IgG antibodies to mono- and poly-ubiquitin.” Kahana, A., Wayner, E., Gottschling, D.E. License supported by the Fred Hutchinson Cancer Research Center, Seattle, WA. Licensed to Berkley Antibody Co., Santa Cruz Biotechnology and others. 2000 “An apparatus for acoustic percussion of the human or animal body.” Kahana, A., Kahana D.D., Kahana, E. U.S. Patent 6485434 2015 “Lacrimal Stent with Opening.” Kahana, A., Jeffrey Plott. Provisional patent application. Serial No. 62/320,789 – Filed: April 11, 2016 U of M Ref. No. 6724 - HDP Ref. No. 2115-006724-US-PS1 CONSULTANCIES - Stryker Corporation, Navigation Division - Genentech, Inc. MENTORING ACTIVITIES Faculty Mentoring 2011 - 2012 Erika Newman, M.D. Assistant Professor of Surgery, Section of Pediatric Surgery 2012 - 2020 Brenda Bohnsack, M.D., Ph.D Assistant Professor of Ophthalmology and Visual Sciences Research Faculty Mentoring Activities 2012 - Present Brenda L. Bohnsack, MD, PhD. Faculty mentor to Dr. Bohnsack’s K08 award, Department of Ophthalmology and Visual Sciences. University of Michigan ASOPRS Oculoplastic Fellows Trained as Associate Preceptor 2007-2009 Raymond Cho, M.D. 2009-2011 Brian Lee, M.D. 2010-2013 Shivani Gupta, M.D., M.P.H. 2011-2013 Cesar Briceno, M.D. 2013-2015 Fatemeh (Pouneh) Rajaii, M.D., Ph.D. 2014-2016 Shannon Joseph (nee Shan), M.D., M.S. 2015-2017 Pimkwan Jaru-Ampornpam, M.D. 2016-2018 Kira Segal, M.D. 2018-2019 Honeylen Teo, M.D. 2018-2020 Dane Slentz, M.D.

Kahana, March 2020,

2019-Present Anais Carniciu, M.D. International Oculoplastics Fellows 2008-2009 Angela Sanchez, M.D., Bogota, Colombia 2019 Nina Jovanovic, M.D., Sarajevo, Bosnia and Herzegovina Postdoctoral Fellows Supervised 2008-2009 Alexandra Calinescu, M.D., Ph.D. 2008-2012 Brenda L. Bohnsack, M.D., Ph.D. 2013-2014 Krista Stewart Rizk, M.D. 2014-2015 Fatemeh (Pouneh) Rajaii, M.D., Ph.D. 2013-2016 Alfonso Saera Vila, Ph.D. 2017-Present Yi Zhao, Ph.D. 2018-Present Shelby Unsworth, Ph.D. Doctoral Students Supervised 2014-2018 Ke’ale W. Louie (Candidate for D.D.S./Ph.D.) Masters Students Supervised 2011-2012 Lindsay Ward Master’s Student, Environmental Health Sciences, School of Public Health Ophthalmology Resident Mentoring Brenda Bohnsack, M.D., Ph.D. (2008-2010) Christina Choe, M.D. (2008-2010) Irina Koreen, M.D., Ph.D. (2009-2010) Dolly Padovani-Claudio, M.D., Ph.D. (2009-2012) Fiorella Saponara, M.D. (2009-2012) Denise Kim, M.D. (2011-2014) Courtney Kauh, M.D., M.P.H. (2012-2015) Krista Rizk Stewart, M.D. (2014-2017) Emily Eton, M.D. (2018-2020) Jara Crear, M.D. (2018-2020) Philip Garza, M.D. (2018-2020) Deonna Vaughn, M.D. (2019-2020) Nicholas Carducci, M.D. (2019-2020) Emily Chang, M.D. (2019-2020) Annie Wu, M.D. (2019-2020)

Medical Students Supervised 2009 Victoria Min, MD University of Michigan Medical Student 2009-2012 Daniel Kasprick, MD University of Michigan Medical Student 2011-2012 Michelle Kron, MD, PhD University of Michigan Medical Student 2014-2015 Chris Y. Wu, MD University of Michigan Medical Student 2018 Amr Sabbagh University of Michigan Medical Student 2018-2019 Alixandra Riddering (VanBelkum) University of Michigan Medical Student 2019-2020 Adrienne Jarocki University of Michigan Medical Student 2019 Rayna Patel University of Toledo, Ohio 2019-2020 Nikki Khandwala University of Michigan Medical Student 2015-Present Curtis Heisel University of Michigan Medical Student

Kahana, March 2020,

Thesis Advisor - Undergraduate Honor Students 2010-2013 Tyler Juntilla Cognitive & Behavioral Science, University of Michigan 2017-2019 Cuilee Sha Biology, University of Michigan 2018-2019 Clara Kim Biology, University of Michigan Training of Undergraduate Students Undergraduate Research Opportunity (UROP) Students Supervised 2010-2013 Tyler Junttila Cognitive and Behavioral 2011 Sarah Wright UROP Student 2011 Marina Haque UROP Student 2011-2015 Amy Robbins Comparative Anthropology 2012-2013 Lynn Daboul Neuroscience 2012 Michael Koszalka Biophysics 2012 Michael Sessine Biology 2015-2017 Vikas Kanneganti Biology 2016-2017 Dustin Tran Biology 2016-2017 Ijoni Lisha Biology Summer Research Opportunity (SROP) Students Supervised 2011 Tyler Junttila Undergraduate Honors Student, Cognitive and Behavioral Neuroscience Program 2012 Amy Robbins Undergraduate in Comparative Anthropology Undergraduate Student Trainees 2007-2011 Donika Gallina (nee Demiri) Ohio State University, PhD program in Molecular, Cellular, and Developmental Biology (now PhD cand., OSU) 2009-2010 Rebecca Kamil Fulbright scholarship in Turkey (2009), the Albert Einstein School of Medicine 2009-2010 Amanda Xi Master’s in Biomedical Engineering, University of Michigan 2009-2011 Ji Yoon Bachelor’s in 12/2012, University of Michigan 2010-2011 Hannah Gregerson Bachelor of Nursing, University of Michigan 2010-2012 Gelareh Abuwerldi Bachelor of Biochemistry, University of Michigan 2010-2013 Tyler Junttila Bachelor of Cognitive and Behavioral Neuroscience,

University of Michigan (now Ophthalmology resident, SUNY Buffalo)

2011 Chris Watson Yale University 2011-2013 Jordan Davidner General Science, University of Michigan 2011-2013 Steven Grzegorski Post-graduate Research Intern (now MSTP at Michigan) 2011 Andrew Chou Biomedical Engineering, University of Michigan 2011 Yunbo Nie University of Pennsylvania 2011 Eli Schultz Columbia University 2012-2014 Alex Sukwon Lee Biology, University of Michigan 2013 Kevin Wheelock Physiology, Michigan State University (now at UMMS) 2013-2014 Bob Wang Biology, University of Michigan 2014-2015 Korri Burnett University of Michigan 2014 Avi Dobrusin Emory Univ.; Central Michigan Univ. School of Medicine 2014 Benjamin Ralston University of Michigan 2014 Justin Yoon University of Michigan 2014 Andrew Carlone University of Michigan 2015 Afreen Qadeer University of Michigan 2011-2017 Amy Robbins University of Michigan

Kahana, March 2020,

2015-2017 Vikas Kanneganti Biology, University of Michigan 2017-2018 Niharika Rajesh Biology, University of Michigan 2017-2019 Cuilee Sha Biology, University of Michigan 2018-2019 Clara Kim Biology, University of Michigan 2018-2019 Ella S. Meyer Biology, University of Michigan 2019-2019 Jonathon Schutt Biology, Calvin College 2019-2019 Reem Farjo Biology, University of Michigan 2019-2020 Matthew Kipp Biology, University of Michigan 2019-2020 Natissa Kelsey Scott Biophysiology, University of Michigan Mentoring of High School Students 2010 (Summer) Chris Watson Greenhills High School, Ann Arbor (Undergrad at Yale) 2019 (Summer) Gaya Pedersen Pioneer High School, Ann Arbor Visiting Scholars 2010 Rhina Bhatt, M.B., B.S., London, Great Britain. International Observership in Oculoplastics 2012 Suzana Matayoshi, M.D., Ph.D., Sao Paulo University, Medical School 2015 Ahmet Murat Sarici, M.D., Istanbul University, Fatih, Istanbul, Turkey TEACHING AND COURSE PARTICIPATION 1992-1994 Graduate Student Seminar Organizer, The University of Chicago 1993 Developmental Biology Advanced Undergraduate Course (Prof. Anthony Mahowald),

Teaching Assistant. The University of Chicago 1994 Gene Expression Regulation I Graduate Course (Profs. Elaine Fuchs & Mark Hochstrasser), Teaching Assistant. The University of Chicago 1995 Gene Expression Regulation II Graduate Course (Profs. Lucia Rothman-Denes & Harrinder

Singh), Teaching Assistant. The University of Chicago 2000-2001 Physical Diagnosis Standardized Patient/Examiner, The University of Chicago 2001 Physical Diagnosis (Dr. Eugene Geppert), Teaching Assistant. The University of Chicago. 2002-2005 Volunteer Instructor, University of Wisconsin Medical School Ophthalmology Practicum, Madison, WI 2002-2005 Volunteer Instructor, University of Wisconsin School of Nursing, Madison, WI 2005 Invited Lecturer, Department of Surgery, Division of Plastic Surgery. University of Wisconsin,

Madison, WI 2005 Invited lecturer, University of Wisconsin Physician Assistant Program. Madison, WI. 2005-2007 Ophthalmic Plastics Resident Lecture Series, Director, University of Wisconsin, Madison, WI. 2006 Director, Multidisciplinary Facial Plastic Surgery Journal Club, Madison, WI. 2006 Invited lecturer, Pediatric Ophthalmology Symposium, Madison, WI. 2006 Instructor, Techniques in facial plastic surgery course, Madison, WI. 2007 Instructor, Orbital Anatomy Dissection Course, University of Wisconsin, Madison, WI. 2008-2010 Instructor, ARVO Ocular Oncology Course 2012-2014 Research Ethics Course, PIBS 503, Kellogg Eye Center, University of Michigan 2013 MEND Fellowship Mentor, Department of Internal Medicine, Metabolism, Endocrinology and Diabetes, University of Michigan 2013 Session Chair, Orbits and Oculoplastics. 28th Asia-Pacific Academy of Ophthalmology Congress (APAO). Hyderabad, India. January, 2013 2011-2019 Applied Lacrimal Physiology, Applied Anatomy of the Head and Neck, University of Michigan 2012-2019 Vision Science Course, OPH 733, Kellogg Eye Center, University of Michigan 2015 Practical Approach in the Interpretation of Orbital Imaging, AAO Annual Meeting, Las Vegas, 2015. 2008-2019 Instructor, 4th year medical students 2013-Present Research Presentation Course, CMB 850, University of Michigan

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2006-2017 Oculoplastics Surgery: Anatomic Foundations, Surgical Techniques, and Enhanced Results. Instructor, AAO Annual Meeting.

2015 Career Seminar Series on Ophthalmology, University of Michigan Medical School 2017 ASOPRS Annual Fall Educational Symposium: Advanced Concepts in Orbital Decompression

Surgery, Instructor, New Orleans, LA 2018 NASAOS 1st Annual Meeting, Washington, D.C. 2018 Stryker Navigational Computer Assisted Technologies Workshop, Instructor, Salt Lake City, Utah 2018 Invited Lecturer, University of Michigan ER Faculty/Fellows 2018 2018 Mid-Winter Oculoplastics Symposium, University of Michigan Kellogg Eye Center 2018 2018 Fall Alumni Day Allied Health Course, University of Michigan Kellogg Eye Center 2019 NASAOS 2nd Annual Meeting, Orlando, Florida 2019 Advanced Concepts in Thyroid Eye Disease. Course Director, AAO Annual Meeting, San Francisco 2019 Orbital Disorders: A Conceptual Approach to Diagnosis and Optimized Decision Making, Course Co-

Director, AAO Annual Meeting, San Francisco 2019 Orbital Radiology - Foundations for Diagnosis and Treatment of Orbital Disease. Course Co-Director,

AAO Annual Meeting, San Francisco 2019 Spotlight on Physician Extenders. Course Director (Invited), AAO Annual Meeting, San Francisco 2008-Present Orbital Anatomy Dissection course codirector, Department of Ophthalmology & Visual Sciences, University of Michigan Medical School VISITING PROFESSORSHIPS 1. Department of Ophthalmology, Tel Aviv University, Israel, January 12, 2012. 2. Department of Ophthalmology, Northwestern University, August 22, 2014. 3. Joan & Gordon Bergy M.D. Lecture, Department of Ophthalmology, University of Washington, September 13,

2014. 4. Department of Ophthalmology, University of Montreal, February 11, 2015. 5. Department of Ophthalmology, University of Colorado, March 6, 2015. 6. Department of Ophthalmology, Stanford University, Palo Alto, CA, October 21-22, 2015. 7. Department of Ophthalmology, University of Toronto, October 29, 2015. 8. Department of Ophthalmology, William Beaumont Medical School, April 24, 2017. 9. Nesi and Black Lecture, Department of Ophthalmology, Kresge Eye Institute, Wayne State University, May 16,

2018 10. Adrian and Gladys Drouhilet Lecture, Ruiz Department of Ophthalmology & Visual Science, University of Texas

– Houston. June 15, 2018. SELECTED PRESENTATIONS 11. Kahana, A., Lisman, J.E. ATP-independent inactivation of rhodopsin in the squid eye. Woods Hole

Marine Biological Laboratory Symposium, 1988 12. Kahana, A., Gottschling, D.E. Ubiquitin-pathway regulation of telomeric silencing. Fred Hutchinson

Cancer Research Center Basic Science Symposium, 1997 13. Kahana, A., Philipson, L. Confocal and fluorescent microscopy of pancreatic islets reveals a role for gap junctions in Synchronization of the Glucose Response. Pritzker School of Medicine 55th Annual Senior Scientific Session, May 2001 14. Kuznetsov, A., Lurie, A., Kahana, A., Martinez, A., Beyer, E., Philipson, L. Role of gap-junctions in

oscillations of cytoplasmic calcium concentration in beta-cells of pancreatic islets. Diabetes, 2002, Vol. 51 (Suppl. 2):A369

15. Kahana, A. Volunteer Instructor, University of Wisconsin Medical School Ophthalmology Practicum, 2002-2005

16. Ip, M.S., Kahana, A., Altaweel, M.A. Intravitreal triamcinolone for the treatment of macular edema. ARVO Annual Meeting, Ft. Lauderdale, FL. May 2003

Kahana, March 2020,

17. Kahana, A., Blodi, B.A., Ip, M.S., Wolf, M. Photodynamic therapy for circumscribed choroidal hemangioma. ARVO Annual Meeting, Ft. Lauderdale, FL. May 2003

18. Kahana, A., Lucarelli, M.J., Langenberg, T., Halloran, M.C. Zebrafish as a model for orbital development. ASOPRS Fall Meeting, Chicago, IL. November 2005

19. Kahana, A., Ophthalmic trauma and emergencies. Invited lecturer, Department of Surgery, Division of Plastic Surgery, University of Wisconsin, Madison, WI. November 2005 20. Kahana, A. Congenital ptosis – a therapeutic challenge. Pediatric Ophthalmology and Adult

Strabismus Symposium. Madison, Wisconsin. September 2006 21. Kahana, A., Langenberg, T., Lucarelli, M.J., Halloran, M.C. Retinoic acid regulates orbital neural crest

development in zebrafish. Graves Disease International Symposium: New Insights for TAO, University of California. Los Angeles, CA. November 2006

22. Kahana, A. Graves Eye Disease – Etiology and indications for steroid treatment. University of Michigan Grand Rounds. September 2007

23. Ahn, H.B., Kulkarni, A., Lucarelli, M.J., Kahana, A. Intra-tarsal epidermal inclusion cyst. ASOPRS Fall Meeting. New Orleans, LA. November 2007

24. Kahana, A., Lucarelli M.J., Grayev A.M., Van Buren J.J., Burkat C.N., Gentry L.R. Noninvasive Dynamic Magnetic Resonance Angiography With Time-Resolved Imaging of Contrast KineticS (TRICKS) in the Evaluation of Orbital Vascular Lesions. ASOPRS Fall Meeting. New Orleans, LA. November 2007

25. Kahana, A. Lucarelli, M.J. Trans-canthotomy lateral cheek resuspension in the treatment of severe lower lid ectropion. ASOPRS Fall Meeting. New Orleans, LA. November 2007

26. Kahana, A. Zebrafish as a model for orbital development and disease. Research Day, Kellogg Eye Center, University of Michigan. June 2008

27. Kahana, A., Elsaeidi, F., Demiri, D, Goldman, D. The roles of twist and retinoic acid signaling in zebrafish orbital neural crest development. Second International Orbital Society Symposium. New York City, NY. September 2008

28. Kahana, A. Collaborative approaches to complex orbitofacial vascular malformations. Alumni Day, Kellogg Eye Center, University of Michigan. September 2008

29. Koreen, I.V., Elner, V.M., Gausas, R.E., Lemke, B.N., Potter, H.D., Kahana, A. Tarsal dermoid cyst: clinical presentation and treatment. ASOPRS Fall Meeting. Atlanta, GA. November 2008

30. Kahana, A. Tearing and dry eyes: common diagnosis with complex etiologies. Allied Health Lecture Series, University of Michigan. 2008

31. Kahana, A. Orbital vascular anomalies: yes we can! Oculoplastic Surgery Spring Symposium, Kellogg Eye Center, University of Michigan. May 2009

32. Kahana, A. Clinical manifestations of hedgehog signaling abnormalities: basal cell nevus syndrome. ARVO Annual Meeting. Ft. Lauderdale, FL. May 2009

33. Kahana, A. Retinoic acid regulates orbital development and extraocular muscle organization in zebrafish. ARVO Annual Meeting. Ft. Lauderdale, FL. May 2009

34. Kahana, A. Bitemporal subcutaneous forehead lift: a helpful option. ASOPRS Spring Meeting. Dana Point, CA. July 2009

35. Kahana, A. Thinking about facial nerve paralysis. Research Day, Kellogg Eye Center. June 2009 36. Kahana, A. Steroids and low-dose radiation therapy: temporizing measures for thyroid eye disease.

Graves Disease Conference. Charlotte, NC. October 2009 37. Kahana, A. Calinescu, A., Bohnsack, B., Elsaeidi, F., Demiri, D., Goldman, D. Retinoic acid and twist1

regulate orbital development and extraocular muscle organization in zebrafish. Society for Development Biology 68th Annual Meeting. San Francisco, CA. October 2009

38. Kahana, A. Intraoperative use of a sclerosing agent – a hybrid procedure for morbid orbital lymphangiomas. ASOPRS Fall Meeting. San Francisco, CA. October 2009

39. Bohnsack, B., Cho, R., Sanchez-Castellanos, A., Parmar, H., Gemmete, J., Maher, C., Nelson, C., Kahana, A. Non-invasive contrast-enhanced magnetic resonance angiography aids eiagnosis and peri-operative planning for orbital venous and arteriovenous malformations. ASOPRS Fall Meeting. San Francisco, CA. October 2009

Kahana, March 2020,

40. Kahana, A. Facial nerve paralysis and blink deficiency. AAO Annual Meeting. San Francisco, CA. October 2009 41. Kahana, A. Orbital vascular lesions and the role of non-invasive imaging. Invited speaker, Oculoplastics

Today, Israel Oculoplastics Congress. Tel-Aviv, Israel. January 2010 42. Kahana, A. A zebrafish model of extraocular muscle development and regeneration. Invited speaker,

Oculoplastics Today, Israel Oculoplastics Congress. Tel-Aviv, Israel. January 2010 43. Kahana, A. Facial nerve palsy and blink dynamics. Invited speaker, Oculoplastics Today, Israel

Oculoplastics Congress. Tel-Aviv, Israel. January 2010 44. Kahana, A. Thyroid eye disease in kids. Tuesday Research Seminar, University of Michigan. March

2010 45. Kahana, A. Facial nerve palsy, lagophthalmos and incomplete blink: my approach. Tri-city Regional

Update Conference. Bay City, MI. March 2010 46. Kahana, A. Orbital vascular tumors: the use of non-invasive angiography and the role of surgery. Tri-city

Regional Update Conference. Bay City, MI. March 2010 47. Kahana, A. Retinoic acid regulates a balance between Pitx2 and Pitx3 expression to promote

morphogenesis of extraocular muscles in zebrafish. Craniofacial Morphogenesis and Tissue Regeneration, Gordon Research Conference. Il Ciocco, Barga, Italy. April 2010

48. Bohnsack, B.L., Kahana, A. IGF regulates neural crest and mesoderm interactions necessary for zebrafish orbital development and extraocular muscle organization. ARVO 2010 Annual Meeting. Ft. Lauderdale, FL. May 2010

49. Kahana, A., Elsaeidi, F.I., Gallina, D.D., Bohnsack, B., Kasprick, D., Goldman, D. Retinoic acid regulates a balance between PitX2 and PitX3 expression to promote morphogenesis of extraocular muscles in zebrafish. ARVO 2010 Annual Meeting. Ft. Lauderdale, FL. May 2010

50. Kahana, A., Gallina, D.D., Bohnsack, B., Kasprick, D., Goldman, D. Retinoic acid, PitX2 and PitX3 regulate zebrafish extraocular muscle development and regeneration. 9th International Conference on Zebrafish Development and Genetics. Madison, WI. January 2010

51. Bohnsack, B.L., Kahana, A. IGF regulates orbital development and extraocular muscle organization in zebrafish. University of Michigan, Kellogg Eye Center 2010 Annual Research Day. Ann Arbor, MI. May 2010

52. Kasprick, D., Kahana, A. A Zebrafish model for extraocular muscle regeneration. University of Michigan, Kellogg Eye Center 2010 Annual Research Day. Ann Arbor, MI. May 2010

53. Kahana, A. Thyroid orbitopathy-related dry eyes as a model for inflammatory dry eyes. Alcon Invited Speaker, Fort Worth, TX. September 2, 2010

54. Kahana, A., Orbital vascular anomalies – diagnosis and treatment. University of Michigan Grand Rounds, Kellogg Eye Center. September 23, 2010

55. Kahana, A. Tales of eyes and orbits: an important biological relationship. Great Lakes Vision Conference. Ann Arbor, MI. October 2, 2010

56. Kahana, A. Pediatric ptosis and orbital vascular tumors. Annual MiSEPS Winter Meeting. Thompsonville, MI. February 26, 2011 57. Kahana, A. Orbital disease and tissue regeneration: what can zebrafish teach us? APAO Sydney

Congress 2011. Sydney, Australia. March 21, 2011 58. Kahana, A. Pediatric ptosis: evaluation and management. William Beaumont Grand Rounds. Royal Oak,

MI. April 11, 2011 59. Kahana, A. Proptosis: evaluation and management of orbital disease. William Beaumont Grand Rounds,

Royal Oak, MI. April 11, 2011 60. Kahana, A. What can zebrafish extraocular muscle regeneration teach us about cancer? Speaker,

Myogenesis Gordon Research Conference. Waterville Valley, NH. September 1, 2011 61. Kahana, A. Stem cells: at the crossroads of science, medicine and policy. University of Michigan

Medical School Annual Alumni Reunion. Ann Arbor, MI. September 10, 2011 62. Kahana, A. Neurologic considerations in oculoplastic surgery. Michael Blumenthal Keynote Lecture,

Israel Microsurgical Convention. Eilat, Israel. January 11, 2012 63. Kahana, A. A zebrafish model of Axenfeld-Rieger Syndrome reveals a basis for variable expressivity in

human patients. Visiting Professor, Department of Ophthalmology. Tel Aviv University,

Kahana, March 2020,

Israel. January 17, 2012 64. Kahana, A. Orbital vascular lesions. Visiting Professor, Department of Ophthalmology, Tel Aviv

University, Israel, January 17, 2012 65. Kahana, A. Dedifferentiated stem cells in muscle regeneration. Weizmann Institute for Science,

Rehovot, Israel, January 18, 2012 66. Kahana, A. Blepharoptosis: more than meets the eye. Annual MiSEPS Winter Meeting. Boyne Falls,

MI. February 25, 2012 67. Kahana, A. Myocyte dedifferentiation underlies zebrafish extraocular muscle regeneration: an

expanding paradigm for therapeutic tissue regeneration. ARVO 2012 Annual Meeting. Ft. Lauderdale, FL. May 7, 2012

68. Kahana, A. Twist genes facilitate skeletal muscle regeneration via myocyte dedifferentiation – a link between tissue repair and cancer. 10th International Conference on Zebrafish Genetics and Development. Madison, WI. June 21, 2012

69. Kahana, A. Using zebrafish to decipher the secrets of thyroid eye disease and extraocular muscle disorders. Annual MiSEPS Summer Meeting. Mackinac Island, MI. Aug 10, 2012

70. Kahana, A. “Fishy business: what can zebrafish tell us about eye disease?” 18th Annual Alumni Day, Kellogg Eye Center, University of Michigan. September 14, 2012

71. Kahana, A. “A multi-disciplinary approach to treating Graves’ disease.” 2012 Graves’ Disease Patient Education Workshop Series. Kellogg Eye Center, University of Michigan. September 15, 2012

72. Kahana, A., Briceno, C. “A comparative study of non-endoscopic surgical approaches to elevation of the forehead and brows.” ASOPRS 43rd Annual Fall Scientific Symposium. Chicago, IL. November 8, 2012

73. Kahana, A. “Hedgehog inhibitor for treatment of orbital basal cell carcinoma.” Great Lakes Ocular Oncology Study Group, Kellogg Eye Center, University of Michigan. December 13, 2012

74. Kahana, A. “The droopy eyelid: more than meets the eye.” Invited Speaker. 28th Asia-Pacific Academy of Ophthalmology Congress (APAO). Hyderabad, India. January, 2013

75. Kahana, A. “Oral vismodegib as a new treatment option for orbital basal cell carcinoma.” Invited Speaker. 28th Asia-Pacific Academy of Ophthalmology Congress (APAO). Hyderabad, India. January, 2013

76. Kahana, A. “Best treatment options for disfiguring periocular vascular anomalies.” Invited Speaker. 28th Asia- Pacific Academy of Ophthalmology Congress (APAO). Hyderabad, India. January, 2013 77. Kahana, A. “Advances in the treatment of thyroid orbitopathy.” Invited Speaker. 28th Asia-Pacific Academy of

Ophthalmology Congress (APAO). Hyderabad, India. January, 2013 78. Kahana, A. “Skin cancer and the eye: an ophthalmic perspective.” Cutaneous Oncology Program (COP) meeting

Department of Dermatology, University of Michigan. April 23, 2013 79. Kahana, A. “Cancer stem cell biology and neural crest development and ocular cancers.” ARVO 2013 Annual

Meeting. Seattle, WA. May 4, 2013 80. Kahana, A. “Stem cells and extraocular muscle regeneration.” University of Washington, Seattle, WA.

May 7, 2013 81. Kahana, A. “Hedgehog inhibitor for orbital basal cell carcinoma.” 85th Annual Spring Postgraduate Conference

and 29th Annual Research Day, University of Michigan. May 31, 2013 82. Kahana, A. “Thyroid Eye Disease-Status post decompression still losing vision.” 85th Annual Spring

Postgraduate Conference and 29th Annual Research Day, University of Michigan. May 31, 2013 83. Kahana, A. “Repair of late complications after trauma.” 85th Annual Spring Postgraduate Conference

and 29th Annual Research Day, University of Michigan. May 31, 2013 84. Kahana, A. “Evolving paradigms in the surgical management of orbital and periocular cancer.” ASOPRS Spring Meeting, Newport, RI. June 2013 85. Kahana, A. “Dynamic imaging and surgical treatment of orbital lymphovenous malformations.” Scientific

Advancements in Ophthalmic Plastics, Implications for the Practicing Ophthalmologist, AAO Pediatric Subspecialty Day. New Orleans, LA. November 16, 2013

86. Kahana, A. “From Zebrafish to Ptosis: why signaling impacts time to ptosis repair.” AAO Annual Meeting, New Orleans, LA. November 17, 2013

87. Kahana, A. “Muscle de-differentiation and motoneuron remodeling in a zebrafish model of muscle injury.” The 3rd European Zebrafish Principle Investigator Meeting. Ein-Gedi, Israel. March 31, 2014

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88. Kahana, A. “Zebrafish eye muscles: a new model for studying the biology of muscle repair and regeneration.” Development Heart/Head Muscle Meeting. Washington D.C. May 12, 2014

89. Kahana, A. “Evolving Paradigms in Diagnostic and Therapeutic Options for Orbital Vascular Anomalies.“ ASOPRS 2014 Spring Symposium. Park City, UT. June 20, 2014

90. Kahana, A. “Changing Paradigms in Oculoplastic Surgery.” Visiting Professor, Northwestern University, August 22, 2014

91. Kahana, A. Joan & Gordon Bergy, M.D. Lecture in Vision Science, “Gained in Translation” Vision Conference, University of Washington, Seattle, WA, September 13, 2014

92. Kahana, A. Zebrafish eye muscles: a new model for studying the biology of muscle repair and regeneration. Bascom Palmer Eye Institute, University of Miami, October 23, 2014

93. Kahana, A. “Efficacy of Vismodegib (Erivedge) For Basal Cell Carcinoma Involving the Orbit and Periocular Area.” Visiting Professor, University of Montreal, February 11, 2015

94. Kahana, A. “Changing Paradigms in Oculoplastic Surgery.” Visiting Professor, University of Colorado, March 6, 2015

95. Kahana, A “Changing Paradigms in Oculoplastic Surgery.” Visiting Professor, Stanford University, Palo Alto, CA, October 21-22, 2015

96. Kahana, A. “Hedgehog Inhibition in the Treatment of Orbital Basal Cell Carcinoma.” Visiting Professor, University of Toronto, October 29, 2015

97. Kahana, A. “Thyroid-Related Orbital Decompression Surgery: An Analysis of Risk Factors and Outcomes.” ASOPRS and AAO Annual Meeting, Las Vegas, NV. November 12, 2015

98. Kahana, A. “Simultaneous versus Staged Balanced Decompression for Thyroid-related Compressive Optic Neuropathy.” ASOPRS and AAO Annual Meeting, Las Vegas, NV. November 13, 2015

99. Kahana, A. “Team Management of Vascular Anomalies.” Wendell Hughes Oculoplastics Symposium, ASOPRS and AAO Annual Meeting, Las Vegas, NV. November 15, 2015

100. Kahana, A. “Graves’ Eye Disease after I-131 Therapy.” SNMMI 2016 Mid-Winter Meeting, Orlando, FL. January 30, 2016

101. Kahana, A. “Differential expression analysis for early gene activation patterns in regenerating lateral rectus muscle.” ARVO Spring Meeting, Seattle, WA. May 2, 2016

102. Kahana, A. “Visomodegib for Orbital and Periocular Basal Cell Carcinoma.” ASOPRS Spring Meeting, Ojai, CA. June 4, 2016

103. Kahana, A. “Autophagy Activation via FGF Signaling Regulates Cytoplasmic Remodeling of Regenerating Adult Zebrafish Myocytes.” The Allied Genetics Conference 2016, Genetics Society of America Annual Meeting, Orlando, FL. July 13-17, 2016

104. Kahana, A. “Nuclear Receptor Ligands: A Role in Triggering Thyroid Eye Disease.” ASOPRS Annual Meeting, Chicago, IL, October 13, 2016

105. Kahana, A. Keynote Lecture, Canadian Ophthalmology Society Annual Meeting, Montreal, June 23, 2017 106. Kahana, A. “Regulation of myocyte reprogramming in muscle regeneration.” The MBL Zebrafish 20th Anniversary Symposium, Woods Hole, MA, August 18, 2017 107. Kahana, A. “Protein/mRNA structure, function and regulation in health and disease.” Michigan- Israel

Partnership for Research and Education Conference, Haifa, Israel, September 5, 2017 108. Kahana, A. “Future directions of Molecularly Targeted Agents in Oculoplastic Surgery.” AAO Fall Meeting,

New Orleans, LA, November 13, 2017 109. Kahana, A. “Orbital vascular anomalies and the role of sclerosis therapy.” San Paulo University Medical School,

San Paulo, Brazil, December 1, 2017 110. Kahana, A. “Congenital ptosis-surgical planning and operative technique.” San Paulo University Medical

School, San Paulo, Brazil, December 2, 2017 111. Kahana, A. EOM and associated tissues: Disease and Development [EY} #1142-1148, ARVO Spring 2018

Meeting, Hawaii, April 30, 2018 112. Comba, A, Zamler, D.B., Dunn, P, Agento, A.E., Kadiyala, P., Yadav, V. N., Motsch, S., Koschmann, C.,

Nunez, F., Kamran, N., Kish, P.E., Castro, M., Kahana, A., and Lowenstein, P. Dynamics of glioma growth: self-organization guides the patterning of the extracellular matrix and regulates tumor progression., Society for Neuro Oncology Conference, New Orleans, LA 2018

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113. Kahana, A. “Hypothesis Development and Staying Focused.” ASOPRS Spring 2018 Meeting, Austin TX, June 2, 2018

114. Kahana, A. “Now You See it, Now You Don’t! Interim Analysis from the VISORB Trial for Periocular Basal Cell Carcinoma.” ASOPRS Fall 2018 Meeting, Chicago, IL, October 26, 2018.

115. Heisel, C.J., Heider, A., Stewart, K.R., Kahana, A. Orbital Septum Fibrosis in Congenital Ptosis Correlates with Eyelid Function: a clinico-pathologic study. ASOPRS Fall 2018 Meeting, Chicago, IL, October 25, 2018.

116. Tingle, C., Zhao, Y., Magnuson, B., Heisel, C., Kish, P.E., Rajapakse, I., Kahana, A. High-throughput Genomic Analysis of Myocyte Dedifferentiation Using Adult Extraocular Muscle Regeneration. International Zebrafish Society Strategic Conference of Zebrafish Investigators (SCZI) 2019 Meeting, Asilomar, CL, January 12-16, 2019.

117. Jovanovic, N., Russell, W.W., Heisel, C.J., Kahana, A. 5-Fluorouracil as First Line Therapy for Conjunctival Cicatrix in OCP and SJS. ASOPRS Fall 2019 Meeting, San Francisco, October 10, 2019.

118. Jacobson, A., Kahana, A. Mucosal 5-FU injections as an adjunct to pediatric DCR improves outcomes. American Academy of Pediatric Ophthalmology and Strabismus Annual Meeting, Austin, Texas, March 25-29, 2020.

PERSONAL Married to Heidi Susan (Cohen) Kahana; 4 children – Adam (23), Ethan (19), Kyra (13) and Arielle (9); Enjoy playing upright bass, guitar and piano and listening to music (especially jazz), playing and coaching sports (golf, tennis, basketball), reading.

BIBLIOGRAPHY PEER REVIEWED JOURNALS AND PUBLICATIONS 1. Kahana, A., Robinson, P.R., Lewis, L.J., Szuts, E.Z., Lisman, J.E. ATP-independent deactivation of squid

rhodopsin. Visual Neuroscience 1992;9:595-602. PMID:1450111 2. Huang, H., Kahana, A., Gottschling, D.E., Prakash, L., Liebman, S.W. The ubiquitin-conjugating enzyme rad6

(Ubc2) is required for silencing in saccharomyces cerevisiae. Molecular and Cellular Biology 1997;17:6693-99.

3. Singer, M.S., Kahana, A., Wolf, A.J., Meisinger, L.L., Peterson, S.E., Goggin, C., Mahowald, M., Gottschling, D.E. Identification of high-copy disruptors of telomeric silencing in saccharomyces cerevisiae. Genetics 1998;150:613-32. PMC1460361

4. Kahana, A., Gottschling, D.E. Dot4p links silencing and cell growth in saccharomyces cerevisiae. Molecular and Cellular Biology 1999;19:6608-20.

5. Kahana, A. The deubiquitinating enzyme Dot4p is involved in regulating nutrient uptake. Biochemical and Biophysical Research Communications 2001;282:916-20. PMID:11352638

6. Ip, M.S., Kahana, A., Altaweel, M.A. Treatment of central retinal vein occlusion with triamcinolone acetonide: an optical coherence tomography study. Seminars in Ophthalmology 2003;18:67-73. PMID:14566625

7. Kahana, A., Gottlieb, J.L. Ophthalmology on the internet: what do our patients find? Archives of Ophthalmology 2004;122:380-82. PMID:15006856

8. Ip MS, Gottlieb JL, Kahana A., Scott IU, Altaweel MM, Blodi BA, Gangnon RE, Puliafito CA. Intravitreal triamcinolone for the treatment of macular edema associated with central retinal vein occlusion. Archives in Ophthalmology 2004;122:1131-6. PMID: 15302652

9. Kahana, A., Rowley, H.A., Weinstein, J.M. Cortical blindness: clinical and radiologic findings in reversible posterior leukoencephalopathy syndrome. Case report and review of the literature. Ophthalmology 2005;112:e7-e11. PMID:15691546

Kahana, March 2020,

10. Kahana, A. Prevention of steroid-induced intraocular pressure elevation. Archives in Ophthalmology 2005;123:1019-20. PMID:16009854

11. Kahana, A., Marcet, M.M., Albert, D.M., Thliveris, A.T. Drug-induced cicatrizing granulomatous conjunctivitis. British Journal of Ophthalmology 2007;91:691-2. PMC1954759

12. Kahana, A., Lemke, B.N., Burkat, C.N., Lucarelli, M.J. Subcutaneous forehead lift: technique and early results. American Journal of Cosmetic Surgery 2007;24:193-200.

13. Kahana, A., Lucarelli M.J., Grayev A.M., Van Buren J.J., Burkat C.N., Gentry L.R. Noninvasive dynamic magnetic resonance angiography with time-resolved imaging of contrast kineticS (TRICKS) in the evaluation of orbital vascular lesions. Archives in Ophthalmology 2007;125:1635-42. (Journal Cover) PMID:18071114

14. Kahana, A., Lucarelli, M.J. Use of radiopaque intraorbital catheter in the treatment of sino-orbito-cranial mucormycosis. Archives in Ophthalmology 2007;125:1714-15. PMID:18071129

15. Langenberg, T., Kahana, A., Wszalek, J.A., Halloran, M.C. The eye organizes neural crest cell migration. Developmental Dynamics 2008; 237:1645-1652. PMID: 18498099

16. Lucarelli, M.J., Ahn, H.B., Kulkarni, A., Kahana, A. Intratarsal epidermal inclusion cyst. Ophthalmic Plastic and Reconstructive Surgery 2008; 24:357-9. PubMed PMID:18806654

17. Kahana, A., Lucarelli, M.J. Adjunctive transcanthotomy lateral suborbicularis fat lift and orbitomalar ligament resuspension in lower eyelid ectropion repair. Ophthalmic Plastic and Reconstructive Surgery 2009; 25:1-6. PMID:19273912

18. Koreen, I.V., Kahana, A., Gausas, R.E., Potter, H.D., Lemke, B.N., Elner, V.M. Tarsal dermoid cyst: clinical presentation and treatment. Ophthalmic Plastic and Reconstructive Surgery 2009; 25:146-7. PMID:19300165

19. Cho RI, Kahana, A, Patel B, Sivak-Callcott J, Buerger DE, Durairaj VD, Vidor I, Mawn LA. Intraoperative fluoroscopy-guided removal of orbital foreign bodies. Ophthalmic Plastic and Reconstructive Surgery 2009;3:215-8. PMID: 19454934

20. Kahana, A., Bohnsack, B.L., Cho, R.I., Maher, C. Subtotal excision with adjunctive sclerosing therapy for the treatment of severe symptomatic orbital lymphangiomas. Archives of Ophthalmology 2011; 129:1073-6. PMCID: PMC3434690

21. Bohnsack, B.L., Gallina, D.D., Thompson, H., Kasprick, D., Lucarelli, M.J., Dootz, G., Nelson, C., McGonnell, I.M., Kahana, A. Development of extraocular muscles require early signals from periocular neural crest and the developing eye, revealing an important developmental window. Archives of Ophthalmology 2011;129:1030-41. PMCID: PMC3248700 (Accompanying editorial.)

22. Kish, P.E., Bohnsack, B.L., Gallina, D.D., Kasprick, D.S., Kahana, A. The eye as an organizer of craniofacial development. Genesis 2011; 49:222-230. PMID:21309065.

23. Bohnsack, B.L., Gallina, D.D., Kahana, A. Phenothiourea sensitizes zebrafish cranial neural crest and extraocular muscle development to changes in retinoic acid and IGF signaling. PLoS One 2011;6:e22991. PMCID: PMC3158757

24. Kasprick, D.S., Kish, P.E., Junttila, T.L., Ward, L.A., Bohnsack, B.L., Kahana, A. Microanatomy of adult zebrafish extraocular muscles. PLoS One, 2011;6:e27095. PMCID: PMC3223174

25. Bohnsack, B.L., Bhatt, R., Kahana, A. Non-Ophthalmic symptoms secondary to ocular torticollis from Severe blepharoptosis: an underappreciated but treatable condition. Ophthalmic Plastic and Reconstructive Surgery 2012;28:e36-9. PMCID: PMC3412122

26. Bohnsack, B.L., Kasprick, D.S., Kish, P.E., Goldman, D., Kahana, A. A zebrafish model of Axenfeld-Rieger Syndrome reveals that pitx2 regulation by retinoic acid is essential for ocular morphogeneis and craniofacial development. Investigative Ophthalmology and Visual Sciences 2012; 53:7-22. PMCID: PMC3292384

27. Kahana, A., Lee, B.J., Flint, A., Elner, V.M. Periocular epithelioid hemangioma: response to bevacizumab and vascular pathogenesis. Archives of Ophthalmology 2012; 130(9):1209-12. PMID: 22965602.

28. Kron M, Bohnsack BL, Archer SM, McHugh JB, Kahana A. Recurrent orbital schwannomas: clinical course and histopathologic correlation. BMC Ophthalmology 2012;12(1):44. PMID: 22937797, PMCID: PMC3503695.

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29. Bohnsack, B.L., Kahana, A. Thyroid hormone and retinoic acid interact to regulate zebrafish neural crest development and human orbital fibroblasts. Developmental Biology 2013; 373(2):300-9. PMID: 23165295.

30. Kahana, A., Worden, F., Elner, V.M. Vismodegib as Eye-Sparing Adjuvant Treatment for Orbital Basal Cell Carcinoma. JAMA Ophthalmology 2013; 131(10):1364-6. PMID: 23907144.

31. Grzegorski, S.J., Chiari, E., Robbins, A., Kish, P.E., Kahana, A. Natural variability of Kozak sequences correlates with function in a zebrafish model. PLoS One 2014; 9(9):e108475. PMID: 25248153, PMCID: PMC4172775

32. Kauh, C., Gupta, S., Douglas, R.S., Nelson, C.C., Elner, V.M., Kahana, A. Compressive Optic Neuropathy and Repeat Orbital Decompression: A Case Series. Ophthalmic Plastic and Reconstructive Surgery 2015; 31(5): 385-90. PMID: 25533274.

33. Kiang, L., Kahana, A. Images in clinical medicine. Orbital Varix. New England Journal of Medicine, 2015; 372(7):e9. PMID: 25671275.

34. Saera-Vila, A., Kasprick, D.S., Chiari, E.F., Grzegorski, S.J., Junttila, T.L., Louie, K.W., Kish, P.E., Kahana, A. Myocyte Dedifferentiation Drives Adult Extraocular Muscle Regeneration in Zebrafish. Investigative Ophthalmology and Visual Sciences 2015; 56(8):4977-4993. PMID: 26230763. PMCID: PMC4525682.

35. Demirci, H., Worden, F.P., Nelson, C.C., Elner, V.M., Kahana, A. Efficacy of Vismodegib (Erivedge) for Basal Cell Carcinoma Involving the Orbit and Periocular Area. Ophthalmic Plastic and Reconstructive Surgery. 2015 Nov-Dec;31(6):463-6. PubMed PMID: 25675162.

36. Saera-Vila, A., Kish, P.E., Kahana, A. Automated Scalable Heat-Shock Apparatus For Standard Aquatic Housing Systems. Zebrafish 2015; 12(4):312-4. PMID: 25942613. PMCID: PMC4523100.

37. Wu, C.Y., Kahana, A. Stereotactic Navigation with a Registration Mask in Orbital Decompression Surgery: Preliminary Results. Ophthalmic Plastic and Reconstructive Surgery. 2015 Nov-Dec;31(6):440-4. PMID: 25675164.

38. Wu, C.Y., Archer, S.M., Kahana, A. “Tag-Team” Orbital and Strabismus Surgeries with Immediate Reconstruction after Tumor Excision Metastatic to the Inferior Rectus. Ophthalmic Plastic and Reconstructive Surgery. 2016 Jan-Feb;32(1):e7-8. PMID: 25650797.

39. Stacey, A.W., Gemmete, J.J., Kahana, A. Management of Orbital and Periocular Vascular Anomalies: A Review. Ophthalmic Plastic and Reconstructive Surgery. 2015;31(6):427-436. PMID: 26560200.

40. Wu, C.Y., Elner, V.M., Kahana, A. Severe Pediatric Thyroid Eye Disease: Surgical Case Series. Ophthalmic Plastic and Reconstructive Surgery. 2017 May/June;33(3S Suppl 1): S186-S188. PMID: 26524159.

41. Wu, C.Y., Kahana, A. Immediate Reconstruction after Combined Embolization and Resection of Orbital Arteriovenous Malformation: A Case Series. Ophthalmic Plastic and Reconstructive Surgery.2017 May/June;33(3S Suppl 1):S140-S143. PMID: 25902385.

42. Vadlamudi V, Gemmete JJ, Chaudhary N, Pandey AS, Kahana A. Transvenous Sclerotherapy of a Large Symptomatic Orbital Venous Varix Using a Microcatheter Balloon and Bleomycin. Journal of NeuroInterventional Surgery. 2016 Aug 8(8):e30. PMID: 26122325.

43. Wu, C.Y., Stacey, A.W., Kahana, A. Simultaneous versus Staged Balanced Decompression for Thyroid-related Compressive Optic Neuropathy. Ophthalmic Plastic and Reconstructive Surgery. 2016 Nov/Dec;32(6):462-467.19(11) PMID:26588206.

44. Klionsky, D.J., Abdelmohsen, K., Abe, A.,Kahana, A., et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12(1):1-222. PMID: 26799652.

45. Rao, R.C., Chan, M.P., Andrews, C., Kahana, A. EZH2 Expression is Associated with High 1 Proliferation Rate and Aggressive Tumor Subtypes in Cutaneous Basal Cell Carcinoma. JAMA Oncology. 2016;2(7):962-963. PMID:27054919.

46. Wu, C.Y., Niziol, L.M., Musch, D.C., Kahana, A. Thyroid-Related Orbital Decompression Surgery: A Multivariate Analysis of Risk Factors and Outcomes. Ophthalmic Plastic and Reconstructive Surgery. 2017 May/June;33(3):189-195. PMID: 27097064.

47. Saera-Vila, A., Kish, P.E., Kahana, A. FGF Regulates Skeletal Muscle Dedifferentiation In Adult Zebrafish. Cellular Signaling. 2016;28(9):1196-1204. PMID 27267062.

Kahana, March 2020,

48. Saera-Vila, A., Louie, K.W., Kish, P.E., Grzegosrki, S.J., Klionsky, D.J., Kahana, A. Autophagy Regulates Cytoplasmic Remodeling During Cellular Reprogramming in a Zebrafish Model of Adult Muscle Regeneration. Autophagy, 2016:2;12(10):1864-1875. PMID 27467399.

49. Wu, C.Y., Kahana, A. Geriatric patients are predisposed to strabismus following thyroid-related orbital decompression surgery: A multivariate analysis. Orbit. 2017 April;36(2):95-101. PMID 28388348.

50. Louie, K.W., Saera-Vila, A., Kish, P.E., Colacino, J.A., Kahana, A. Temporally distinct transcriptional regulation of myocyte dedifferentiation and Myofiber growth during muscle regeneration. BMC Genomics, 2017; 18:854.

51. Heisel, C., Zacks, D.N., Kahana, A. Persistent Macular Puckering Following Excision of Causative Orbital Tumor. AJO Case Reports, 2018; 10:196-7. PMID: 29756077

52. Saera-Vila, A, Louie, KW, Sha, C, Kelly, RM, Kish, PE, Kahana, A. Extraocular muscle regeneration in zebrafish requires late signals from Insulin-like growth factors. PLoS One, 2018:13(2): e0192214. https://doi.org/10.1371/journal.pone.0192214.

53. Prendes MA, FU R, Lamb IW, Nunery WR, Kahana A, Lee HBH. Retrospective analysis of physician-based surveys. Ophthalmic Plastic Reconstructive Surgery. Epub ahead of print. 2018 Jan 19. PMID: 29356717.

54. Saera-Vila, A., Kish, P.E., Kahana, A., Autophagy in Zebrafish Extraocular Muscle Regeneration. Methods Mol Biol. 2018. PMID: 29797006

55. Rao, R.C., Chan, M.P., Andrews, C., Kahana, A. Epigenetic Markers in Basal Cell Carcinoma: Universal Themes in Oncogenesis and Tumor Stratification? - A Short Report. Cellular Oncology. 2018, Epub ahead of print. PMID: 30215205.

56. Hikage, F., Atkins, S., Kahana, A., Smith, T., Chun, T. HIF2A Drives Orbital Adipose Tissue Fibrosis and Inflammatory Gene Expression in Graves’ Orbitopathy. Endocrinology. 2018, Epub ahead of print, en.2018-00272.

57. Zhao, P.Y., Kahana, A., Kim, T.N. Blurred Vision and Wrinkled Retinas. JAMA Ophthalmology, in press. 58. Shaughness, G.J., Segal, K.L., Kahana, A., Absorbable implant foreign body reaction masquerading as orbital

cellulitis Ophthalmic Plast Reconstr Surg. 2018, Epub ahead of print. 59. Michelson, S.J., Ciongoli, M.R., Elner, V.M., Kahana, A. Socket reconstruction with bleomycin, gentamicin, and

gelatin sponges following eyelid-sparing orbital exenteration for a colobomatous macrocyst in an infant. Ophthalmic Plast Reconstr Surg 2018, Epub ahead of print.

60. Heisel, C.J., Amer, H., Stewart, K.J., Andrews, C.A., Kahana, A. Orbital Septum Fibrosis in Congenital Ptosis Correlates With Eyelid Function: A Clinicopathologic Study. Ophthalmic Plastic Reconstructive Surgery, 2019, Epub ahead of print.

61. Weadock, William J., Kahana, A. Use of 3D printed models to create molds for shaping implants for surgical repair of orbital fractures. Academic Radiology, S1076-6332(19):30373-3. PubMed PMID: 31466890.

62. Tingle, C.F., Magnuson, B., Zhao, Y., Heisel, C.J., Kish, P.E., Kahana, A. Paradoxical Changes Underscore Epigenetic Reprogramming During Adult Zebrafish Extraocular Muscle Regeneration. Investigative Ophthalmology and Visual Science, 2019; 60(15):4991-9.

63. Heisel, C.J., Riddering, A.L., Andrews, C.A., Kahana, A. Serum Vitamin D Deficiency is an Independent Risk Factor for Thyroid Eye Disease. Ophthalmic Plastic Reconstructive Surgery, 2020; 36(1):17-20. PMID: 31568022.

64. Desjarlais, E.B., Jovanovic, N., Teo, H.M., Kahana, A. Surgical management of an orbit-eroding mucopyocele secondary to frontal-ethmoidal sinus inverting papilloma. Ophthalmic Plastic and Reconstructive Surgery, in press.

65. Jovanovic, N., Carniciu, A.L., Russell, W.W., Jarocki, A., Kahana, A. Reconstruction of the Orbit and Anophthalmic Socket Using the Dermis Fat Graft: A Major Review. Ophthalmic Plastic and Reconstructive Surgery, in press.

66. Jovanovic, N., Russell, W.W., Heisel, C.J., Hood, C.T., Kahana, A. Direct Injection of 5-Fluorouracil Improves Outcomes in Cicatrizing Conjunctival Disorders Secondary to Systemic Disease. Submitted.

67. Zhao, Y., Louie, K.W., Tingle, C.F., Sha, C., Heisel, C.J., Unsworth, S.P., Kish, P.E., Kahana, A. Twist3 is required for dedifferentiation during extraocular muscle regeneration in adult zebrafish. Submitted.

68. Unsworth, S.P., Heisel, C.J., Tingle, C.F., Rajesh, N., Kasprick, D.S., Kish, P.E., Kahana, A. Retinoic Acid

Kahana, March 2020,

Potentiates Orbital Tissues for Inflammation through NFkB and MCP1. In preparation. 69. Unsworth, S.P., Tingle, C.F., Kish, P.E., Kahana, A. Molecular characterization of persistent tumors in patients

following pharmacologic hedgehog inhibition of basal cell carcinoma reveals accumulation of resistant mutations. In preparation.

70. Kahana, A., Unsworth, S.P., Kish, P.E., Chan, M., Bresler, S., Bichakjian, C., Durham, A., Demirci, H., Elner, V.M., Nelson, C.C., Joseph, S.S., Kim, D., Worden, F. Vismodegib for orbital and periocular basal cell carcinoma: results from the VISORB trial. In preparation.

INVITED EDITORIALS (PEER REVIEWED) 1. Kahana, A., Elner, V.M. The Meaning of Diagnoses in Orbital Disease. Ophthalmic Plastic and Reconstructive

Surgery, 2013: 29(5):347-8. 2. Unsworth, S., Heisel, C.J., Kahana, A. A New Paradigm in the Treatment of Advanced Periocular Basal Cell

Carcinoma. American Journal of Ophthalmology, 2019, in press. LETTERS TO THE EDITOR 1. Kahana, A., Dutton, J. Evisceration is useful in certain situations. Archives in Ophthalmology 2010; 128:1496.

PMID:21060058 2. Kahana, A., Gemmete, JJ., Stacey, A.W., Re: “Periorbital Sclerotheraphy Caution” [Letter]. Ophthalmic Plastic

and Reconstructive Surgery. May-Jun 2016, 32(3):238-239. PMID: 27149612. 3. Kahana, A., Kotlus, B., Black, E. Re: “Assessing the Effectiveness of Arnica montana and Rhododendron

tomentosum (Ledum palustre) in the Reduction of Ecchymosis and Edema After Oculofacial Surgery: Preliminary Results” [Letter]. Ophthalmic Plastic and Reconstructive Surgery. 2017 Jan/Feb;33(1):74.

BOOK CHAPTERS 1. Kahana, A., Levin, L.A. Peripheral nerve tumors of the orbit. In “Albert and Jakobiec’s Principles and Practice of

Ophthalmology,” Albert, D.A. and Miller, J.W., Editors. Saunders, 3rd Edition, 2007. 2. Kahana, A., Burkat, C.N., Lucarelli, M.J., Dortzbach, R.K. Diagnosis and management of orbital fractures. In

“Atlas of the Orbit,” Subrahmanyam Mallajosyula, Editor. Jaypee Brothers, India, 2008. 3. Kahana, A., Lucarelli, M.J. Corneal protective procedures: tarsorrhahy and lacrimal occlusion. In “Corneal

Surgery, Fourth Edition,” Frederick S. Brightbill, Peter J. McDonnell, Charles N.J. McGhee, Ayad A. Farjo, and Olivia Serdarevic, Editors. Mosby, 2009.

4. Kahana, A., Pribila, J.T., Nelson, C.C., Elner, V.M. Sebaceous cell carcinoma. In “Ocular Disease: Mechanisms and Management,” Daniel M. Albert and Leonard A. Levin, Editors. Saunders, 2010.

5. Bohnsack BL, Nelson CC, Kahana A. Evisceration. In: “Clinical Atlas of Procedures in Ophthalmic and Oculofacial Surgery,” Daniel M. Albert, Mark J. Lucarelli, Editors. Oxford University Press, 2nd edition, 2011.

6. Kahana, A. Transcranial approach to the orbit. In “Smith and Nesi’s Ophthalmic Plastic and Reconstructive Surgery” Frank Nesi, Christopher Calvano, Evan Black, Editors. Springer Medical Publishing, 3rd edition, 2012.

7. Cho, R.I., Kahana, A. Orbital exenteration. In “Smith and Nesi’s Ophthalmic Plastic and Reconstructive Surgery” Frank Nesi, Christopher Calvano, Evan Black, Editors. Springer Medical Publishing, 3rd edition, 2012.

8. Kahana, A. Orbital vascular anomalies. In “Smith and Nesi’s Ophthalmic Plastic and Reconstructive Surgery” Frank Nesi, Christopher Calvano, Evan Black, Editors. Springer Medical Publishing, 3rd edition, 2012.

9. Gupta, S., Demirci, H., Lee, B.L., Elner, V.M., Kahana, A. Orbital inflammatory diseases. In “Smith and Nesi’s Ophthalmic Plastic and Reconstructive Surgery” Frank Nesi, Christopher Calvano, Evan Black, Editors. Springer Medical Publishing, 3rd edition, 2012.

10. Kahana, A. Cranial Nerves: Central and Peripheral Connections. In “BCSC Fundamentals and Principals of Ophthalmology”, Section 2, (Editors: Lawrence M. Levine, Vikram S. Brar, Michael H. Goldstein, Alon Kahana, William R. Katowicz, Simon K. Law, David A. Mackley), 2014.

11. Kahana, A. Ocular Development. In “BCSC Fundamentals and Principals of Ophthalmology”, Section 2, (Editors: Lawrence M. Levine, Vikram S. Brar, Michael H. Goldstein, Alon Kahana, William R. Katowicz, Simon K. Law, David A. Mackley), 2014.

Kahana, March 2020,

12. Kahana, A.: Orbital Tumors and Malformations. OPBR1515, Audio Digest Ophthalmology Comprehensive Review, 2015.

13. Carniciu, A., Kahana, A. Pathogenesis and Medical Management of Thyroid Eye Disease, Smith and Nesi’s Ophthalmic Plastic and Reconstructive Surgery, 4th Edition, 2020, in press.

14. Carniciu, A., Cho, R.I., Kahana, A. Surgical Rehabilitation for Thyroid Eye Disease, Smith and Nesi’s Ophthalmic Plastic and Reconstructive Surgery, 4th Edition, 2020, in press.

15. Carniciu, A., Kahana, A. Image Guided Orbital Surgery, Smith and Nesi’s Ophthalmic Plastic and Reconstructive Surgery, 4th Edition, 2020, in press.

16. Erickson, T., Heisel, C.J., Bichakjian, C.K., Kahana, A. Carcinoma of the Eyelids. Albert and Jakobiec’s Principles and Practice of Ophthalmology,” Albert, D.A. and Miller, J.W., Editors. Saunders, 4th Edition, 2020, in press.

BOOK SECTION EDITOR Orbital Disease and Surgery, Smith and Nesi’s Ophthalmic Plastic and Reconstructive Surgery, 4e, (Editors: Evan H. Black, Frank A. Nesi, Javier Servat), Springer, New York, 2020. Orbital Disease and Surgery, Smith and Nesi’s Ophthalmic Plastic and Reconstructive Surgery, 3e, (Editors: Evan H. Black, Frank A. Nesi, Christopher J. Calvano, Geoffrey J. Gladstone, Mark R. Levine), Springer, New York, 2012. BCSC Fundamentals and Principals of Ophthalmology, Section 2, (Editors: Lawrence M. Levine, Vikram S. Brar, Michael H. Goldstein, Alon Kahana, William R. Katowitz, Simon K. Law, David A. Mackley), San Francisco, California, 2014. Orbital Disease and Surgery, Smith and Nesi’s Ophthalmic Plastic and Reconstructive Surgery, 4e, (Editors: Javier

Servat, Evan H. Black, Frank A. Nesi, Christopher J. Calvano), Springer, New York, 2020, in press. EDITORIAL BOARD MEMBERSHIPS Oculoplastic Surgery Section, Ocular Surgery News, 2013-Present. BOOK REVIEWS 1. Kahana, A.: Manual of Endoscopic Lacrimal and Orbital Surgery, by John J. Woog, ISBN 0-7506-7326-5, Elsevier, Archives in Ophthalmology, 2004, Vol. 122:1576. 2. Kahana, A.: Ophtho Notes: The Essential Guide, by Randall L. Goodman, TNY ISBN 1-58890-171-8, Thieme, Archives in Ophthalmology, 2004, Vol. 122:1577. 3. Kahana, A.: Manual of Oculoplastic Surgery, 3rd Edition, by Mark R. Levine, ISBN 0-7506-7410-5, Butterworth-Heinemann, Archives in Ophthalmology, 2004, Vol. 122:1890-1. 4. Kahana, A.: Anterior Segment Repair and Reconstruction: Techniques and Medico-Legal Issues, by Bruce A. Noble, Ian G. Simmons, and Bernard Y.P. Chang, ISBN 0-7506-4573-3, Butterworth Heinemann, Archives in Ophthalmology, 2005, Vol. 123:413-4. 5. Kahana, A.: Phaco-Chop: Mastering Techniques, Optimizing Technology, and Avoiding Complications, by

David F. Chang. ISBN 1-55642-679-8, Slack, Archives in Ophthalmology, 2005, Vol. 123:1286-7.

6. Kahana, A.: Phacodynamics: Mastering the Tools and Techniques of Phacoemulsification Surgery, by Barry S. Seibel. ISBN 1-55642-688-7, Slack, Archives in Ophthalmology, 2005, Vol. 123:1762. 7. Kahana, A.: Eyelid and Periorbital Surgery, by Clinton D. McCord, Jr. ISBN-13: 978-1576262191, Quality Medical Publishing, Inc., 2008. E-BLASTS 1. Gappy, S., Archer, S., Kahana, A., Atypical treatment for an atypical presentation. University of Michigan, Kellogg

Eye Center Grand Rounds. Broadcast email from [email protected], July 17, 2108 2. Sweet, E., Kahana, A., Archer, S., Strabismus following trauma. University of Michigan, Kellogg Eye Center.

Grand Rounds. Broadcast email from [email protected], October 16, 2018

Kahana, March 2020,

3. Garza, P.S., Kahana, A. Rapidly progressive unilateral proptosis in a child. University of Michigan, Kellogg Eye Center. Grand Rounds. Broadcast email from [email protected], April 10, 2019

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