personalising crispr genome editing || edward perello || disruptor stories
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@EdwardPerello | @DesktopGenetics© Desktop Genetics Ltd. 2016 An Illumina-backed company
PERSONALISING CRISPRGENOME EDITING
August 2016
Edward Perello| CBO & Founder
@EdwardPerello | @DesktopGenetics
DESKTOP GENETICSHELPING YOU MANIPULATE GENOMES
LONDONEST. 2012
BIOINFORMATICS TOOLS
GENE EDITING SERVICES
BACKED BY LARGEST SEQUENCING PROVIDER
@EdwardPerello | @DesktopGenetics
TWO PATHS TO DESKTOP GENETICSPRODUCTS & SERVICES DATA
@EdwardPerello | @DesktopGenetics 4
TEACH AI TO PERFORM GENETIC SURGERYMACHINE INTELLIGENCE IS THE ONLY WAY TO EDIT THE GENOME SAFELY
@EdwardPerello | @DesktopGenetics
AGENDA
1. Brief intro to CRISPR
2. Our story so far
3. Taking CRISPR to the clinic
@EdwardPerello | @DesktopGenetics© Desktop Genetics Ltd. 2016 An Illumina-backed company
Editing the Genome with CRISPR
@EdwardPerello | @DesktopGenetics
GENE THERAPY TACKLES DISEASESCRISPR is used to modify the genome of a patient’s cells
@EdwardPerello | @DesktopGenetics
CRISPR OVERVIEWProgrammable two-component system
CAS9 NUCLEASE
RNACOMPONENT
@EdwardPerello | @DesktopGenetics
CRISPR OVERVIEWProgrammable two-component system
CAS9 NUCLEASE
RNACOMPONENT
VARIABLE20 BP GUIDE RNA
CONSTANTREGION
@EdwardPerello | @DesktopGenetics
CRISPR OVERVIEWProgrammable two-component system
CAS9 NUCLEASE
RNACOMPONENT
ACTIVE RNA-GUIDED CAS9
COMPLEX
@EdwardPerello | @DesktopGenetics
CRISPR OVERVIEWMolecular find and replace for DNA
Source: McGovern Brain Institute Youtube Channel
@EdwardPerello | @DesktopGenetics
WHY EDIT GENOMES?Research & development → Clinical interventions
- Degenerative blindness- Custom disease models
- Humanization of heart valves- Swine fever resistance
- HIV eradicated in vitro- Immuno-oncology
- Clinical trials cured cancer - Clinical trials cured HIV
@EdwardPerello | @DesktopGenetics
WHY START A BUSINESS IN THIS SPACE?Huge biotechnology, life science and clinical prospects
75M PATIENTS3M RESEARCH EXPERIMENTS
@EdwardPerello | @DesktopGenetics© Desktop Genetics Ltd. 2016 An Illumina-backed company
Our Story
@EdwardPerello | @DesktopGenetics
2011 – MEETING AT CAMBRIDGEMPHIL BIOSCIENCE ENTERPRISE DEGREE
@EdwardPerello | @DesktopGenetics
2012 – SYNTHBOT, CUTEC, SEEDTHE BIOTECH NESPRESSO
@EdwardPerello | @DesktopGenetics
2013 – AUTOCLONE, TSB , RAISEHARDWARE OUT, SOFTWARE IN
@EdwardPerello | @DesktopGenetics
2014 – HORIZON CRISPR TOOL & TSBINTERNAL CRISPR R&D TOOL
@EdwardPerello | @DesktopGenetics
2014 - GUIDEBOOKCO-BRANDED CRISPR DESIGN & SALES PORTAL
@EdwardPerello | @DesktopGenetics
2015 – DESKGEN, CLASS, PARTNERSUNITING & OPTIMISING OUR TOOLSET
@EdwardPerello | @DesktopGenetics
CRISPR EXPERIMENTS MODE, RICHER UI2015 – DESKGEN, CLASS, PARTNERS
@EdwardPerello | @DesktopGenetics
2015 – DESKGEN, CLASS, PARTNERSPARTNERSHIPS MAKE LITERAL DESKTOP GENETICS POSSIBLE
@EdwardPerello | @DesktopGenetics© Desktop Genetics Ltd. 2016 An Illumina-backed company
Taking CRISPR into the clinic
@EdwardPerello | @DesktopGenetics
INTERNATIONAL ENDEAVOURCRISPR is a global phenomenon
@EdwardPerello | @DesktopGenetics
2016 – GUIDE PICKER, NGS, BEYONDMULTIDIMENSIONAL GUIDE SELECTION
@EdwardPerello | @DesktopGenetics
2016 – GUIDE PICKER, NGS, BEYONDUSING BIOLOGICAL DATA TO TAKE OUR AI FURTHER
@EdwardPerello | @DesktopGenetics
HUMANS VS. MACHINESMACHINES OUT-PERFORM MANUAL DESIGN
CRIS
PR S
ucce
ss R
ate
@EdwardPerello | @DesktopGenetics 28
PERFORM GENETIC SURGERY WITH AIDesign CRISPR for every lab, teach our algorithms, go to the clinic
@EdwardPerello | @DesktopGenetics
LIFE AT DESKTOP GENETICSRecognition in tech, biology, and everything in between
@EdwardPerello | @DesktopGenetics
WE’RE HIRINGJoin us in Shoreditch; tell your friends!
@EdwardPerello | @DesktopGenetics© Desktop Genetics Ltd. 2015© Desktop Genetics Ltd. 2
www.deskgen.com
edwardp@desktopgenetics.com
@edwardperello
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