Breakout 1: Workforce Development, Team Science and Stakeholder Engagement

Breakout Discussion Leads:• Mark Chance, PhD• Elaine Borawski, PhD

Louis StokesCleveland VA Medical Center

December 6, 2018External Advisory Committee

Workforce Development and Pilots

Mark Chance, PhDTranslational Endeavors Component Lead

Early Years of TT Core and Translational Development

• Council to Advance Human Health (CAHH) established 2012; alumni advisors recruited

• CTOs hired to shepherd projects forward• Money raised through philanthropy to accelerate projects• CTSC establishes Office of Translation and Innovation

Bill HarteBlair GehoAnne DeChantMark Chance

Past: Clinical and Translational Science Award

• Focused on clinical infrastructure and connecting to basic science research

• Pilots foundation for achieving new NIH grants• No explicit Translational Workforce Development

or entrepreneurship missions in TT Core

Changes since 2012: Translational Funding Opportunities

• Council to Advance Human Health – 2012Expansion

• Connect with Coulter in OTI-2012 • Ohio Third Frontier– 2012, extended 2017• NIH Center for Accelerated Innovation - 2014• Taipei Medical University Partnership - 2016• CTSC Pilot Program – 2019 (new focus on innovation)

Current Office of Translation and Innovation

Michael HaagStephanie

Weidenbecher

Bill HarteBlair GehoAnne DeChantMark Chance

Ofer ReizesSteve Fening

Daria Fedyukina

Translational funding programs de-risk assets

CAHH NCAI TMU CTSC CCTRP OTF/CTF

Vetting Projects

Project Mgmt

Marketing

Translational Funding Opportunities

$300 million in University Research

Added

Deals!

Translational Endeavors

• Focused on changing culture and streamlining processes to move research forward

• Funding innovative pilots• New programs in entrepreneurship, mentoring, and

training in innovation

Translational Workforce Development

Provide translational and clinical workforce training and education opportunities

• CWRU Venture Mentor Program• EnRICH Internship Program• On-site events and programming at affiliate hospitals and

around CLE• Connect with iCorps, C3i and other state and national

training programs

CWRU Venture Mentor Program

• Mentoring CWRU entrepreneurs in developing ventures for biotech related discoveries

• Team mentoring from local industry experts focused on translational research and transitioning projects to industry or clinic

• Creates safe, confidential space

Workshops & Seminars

Team Mentoring

Building Networks

Enhancing Research and Industry Career Horizons (EnRICH)

• Internship & career exposure provides career guidance, mentorship, exposure to various work environments, new skills and techniques

• Opportunities in special projects, shadowing, volunteer, immersive and traditional

• Consulting, Education, Industry, Non-Profit, etc.

Annual Pilot Program

Streamline the Annual Pilot to encourage more translational programs• New RFA template with clear translational milestones and

expectations• Updated review process with translational experts• Rigorous project management • Encourage translational programs to apply• Connect to other translational programs for strategic funding• Entrepreneurship training as part of award

Summary

• Learned from challenges we faced in the past• Presently expanding programs that are shown to

provide added value

• Continue to build collaborations, connect to the entrepreneurship community, and participate in developing the biotech ecosystem of Northeast Ohio

Team Science & Stakeholder Engagement

Elaine A. Borawski, PhDCommunity and Collaboration Component Lead

Louis StokesCleveland VA Medical Center

CTSC RESOURCES TO SUPPORT C/T RESEARCH

RESOURCES TO SUPPORT CLINICAL AND

TRANSLATIONAL RESEARCH

INFORMATICS

RESEARCH METHODS

COMMUNITY AND COLLABORATION

HUB RESEARCH CAPACITY

TRANSLATIONAL ENDEAVORS

NETWORK CAPACITY

“Big data”, EHR data, tools to collect, analyze and visualize data Trial Innovation Network; collaborative research with other CTSA hubs across

the country.

Biostatistics, Epidemiology and Research Design (BERD) and

Regulatory Knowledge and Support

Study recruitment, assessments, management, and Integrating

Special Populations

Workforce development and pilot grant funding

KL2 Scholars

TL1Scholars

TRAINING PROGRAMS

Promote collaboration through team science, with intentional stakeholder engagement

COMMUNITY AND COLLABORATION TEAM

Elaine Borawski Kurt Stange Mark Chance Shirley Moore Darcy Freedman Heidi Gullett

Jim Werner Bill Harte Anne DeChant Anna Matos Rachel Gardenhire

The Translational Science Continuum

SOURCE: Institute of Medicine. 2013. The CTSA Program at NIH: Opportunities for Advancing Clinical and Translational Research. Washington, DC: The National Academies Press.

DEFINING TRANSLATION IN 2018

• Translation is “the process of turning observations in the laboratory, clinic, and community into interventions that improve the health of individuals and populations –from diagnostics and therapeutics to medical procedures and behavioral interventions.”

--NIH National Center for Advancing Translational Sciences (NCATS)

COMMUNITY….REDEFINED

The term community includes all stakeholders connected to clinical and translational research. Communities may include but are not limited to non-profit or industry entities engaged in translational research, and might include disease advocacy groups, local health providers, community-based organizations, and other national or local communities.

--NIH National Center for Advancing Translational Sciences (NCATS)

OUR NEW FOCUS

Community and Collaboration=

Team Science with Stakeholder Engagement

What is a Scientific Research Team?

Level of Interaction and IntegrationLOW HIGH

Investigator-Initiated Research

Investigator works on a scientific program – largely on his or her own.

Research Collaboration

• Group works on a scientific problem, each bringing some expertise to the problem.

• Each member works on a separate part, which are integrated at the end.

• The interaction of the lead investigators varies from limited to frequent with regard to data sharing or brainstorming.

Integrated Research Team

• Team works on a research problem with each member bringing specific expertise to the table.

• There are regular meetings and discussions of the team’s overall goals, objectives of the individuals on the team, data sharing, and next steps.

• One person takes the lead while other members have key leadership roles in achieving the goal.

….think of it as a continuum…..

SOURCE: Bennett, L. M., & Gadlin, H. (2012). Collaboration and team science: from theory to practice. Journal of Investigative Medicine, 60(5), 768-775.

Cell/AnimalLaboratory

PatientsClinic/Hospital

INFORMATICS/DATA SCIENCE

Who are the investigators on these teams?

People (with or without diseases)Public Health, Community

What (and whom) is a Stakeholder?

• Stakeholder is an independent, engaged, individual or group who has a stake in the outcome, and whose input could greatly enhance the research endeavor.

• Type of stakeholder may vary depending on the focus of the problem, the type of research conducted, and the composite and orientation of the investigative team.

Cell/AnimalLaboratory

PatientsClinic/Hospital

National Center for Accelerated Innovations

Council to Advance Human Health

Who are the Stakeholders?

People (with or without diseases)Public Health, Community

Safety Net Provider Alliance

Cross-disciplinary teams conducting translational researchResearch Teams that include relevant

Stakeholders –individuals, groups and/or organizationsthat have a stake in the outcome, whose input could greatly enhance the research endeavor, and that can serve as critical partners in the translational process.

Research teams that include bothcross-disciplinary investigators AND stakeholders, collectively approaching a problem.

Our Goal: Promoting a Culture of Team Science with Stakeholder Engagement

Why Stakeholder Engagement is ImportantKnowledge to Action (K2A) Framework

Where stakeholders/

practitioners mostly spend their time

Where researchers

mostly spend their time

Why Stakeholder Engagement is ImportantKnowledge to Action (K2A) Framework

Knowledge to Action (K2A) Framework

Products:• Pubs and Reports• Actionable interventions:

drugs, devices, programs, protocols, guidelines, toolkits

FOUR AIMS OF THE C&C COMPONENT

• Aim 1: Create and foster opportunities for new collaborative teams (that include stakeholders) to form and produce novel and relevant translational research;

• Aim 2: Build capacity of community and clinical partners to be strong and equitable translational partners and collaborators;

• Aim 3: Build capacity for team science among faculty, staff, students, and community collaborators;

• Aim 4: Establishing team science (with stakeholder engagement) as a valued institutional norm.

Aim 1: Developing Collaborative Teams

• Start with existing translational collaboratives – those with interdisciplinary researchers AND stakeholders already at the table. Examples:– National Center for Accelerated Innovations (lab to industry)– Better Health Partnership (primary care and pediatric – hypertension,

diabetes and childhood obesity)– Health Improvement Plan, Cuyahoga County (4 priorities)– First Year Cleveland (infant mortality)– Northeast Ohio Opioid Consortium– Cut the Rate in Half Initiative (tobacco & cancer)

Aim 1: Developing Collaborative Teams

With established collaboratives:• Link them to the CTSA. Identify the potential.• Provide administrative assistance with planning meetings; • Provide pilot grant opportunities;• Help to identify new grant opportunities;• Provide stakeholders with support and training to be effective

grant collaborators or to lead the grant submission (Aim 2)• Provide assistance with dissemination of findings. • Progress reports and performance milestones (# grants, new

technologies, manuscripts, and toolkits) for each engaged group.

• Identifying existing, successful teams – Submissions to the national team science contests.– Identify possible case studies to follow over time (Breckenridge)

• Identifying NEW teams– Speed networking event “PechaKucha”- style (e.g., 5 slides, 5

minutes to describe your research).

• Helping to link stakeholder groups to investigative groups.– Develop list of current stakeholder groups across all investigative

types.– Developing a communications plan

Aim 1: Developing Collaborative Teams

Aim 2: Building capacity of community and clinical partners to be translational partners• Increase awareness of CTSC commitment to stakeholder

engagement.• Develop workshops and tailored modules around K2A framework to

disseminate to investigator and stakeholder groups.• Grants Prep Team:

– provide support to community and clinical stakeholders partnering on research grants.– Assistance with biosketches, becoming CREC certified, assurances and compliance

regulations, and provide support for navigating grants.gov and eRA Commons.

• System for providing stakeholders access to university library resources.

• Update CWRU CTSC website content with services and resources

• Team Science course (Shirley Moore, Mary Delansky)• Encourage all KL2 and TL1 scholars to take course.• Share best practices of Team Science course with directors and

advisors of all T32 and K programs.

• National Team Science Consultation (Maritza Salazar , UC Irvine)• Increase awareness of the “science of team science”.• NSF Grant to develop and test national team science curricula.• Offering two, 90-min group sessions on team communication

and strategic planning. Current have 6 teams signed up.

Aim 3: Build capacity for team science among faculty, staff, students, and stakeholders

• Development of “portable” team science modules (based on curriculum) that can be used in department meetings, faculty retreats, collaborative meetings.

• Small group training (multidisciplinary) seminars in Team Science at frequent intervals each year.

• Establish a Team Science Success Seminar series, highlighting successful team and team science research.

• Identify teams that would benefit from TS support• Offer a 2-hr Team Building workshop for new research teams

(e.g., pilots), or those experiencing challenges.

Aim 3: Build capacity for team science among faculty, staff, students, and stakeholders

Aim 4: Establishing Team Science with Stakeholder Engagement at a valued institutional norm

• How to help move the institutional culture to support, value and incentivize team science participation AND stakeholder engagement.

• Much progress has already been made with regard to team science (P&T), less so with stakeholder engagement.

• However, need to move beyond our current definition of a “team scientist” to incentivize team science.

• How to engage team participation in an independent investigator focused environment?

Aim 4: Establishing Team Science with Stakeholder Engagement as a Valued Institutional Norm

• Document team science promotion and tenure successes.• Develop and distribute toolkit for faculty and departmental CAPT

to better understand team science and stakeholder engagement. • Document team science and collaboration by adding new tab to

Annual Faculty Activity Summary – asking faculty to report on team scientist collaborations, as well as grants and scholarships that include stakeholders

• Promulgate team science best practices and, in concert with Translational Endeavors and the OTWD, disseminate these educational opportunities to the workforce across the CTSC institutions.

Aim 4: Establishing Team Science with Stakeholder Engagement as a Valued Institutional Norm

Showcasing Collaborative Teams and their Work through:• CTSC newsletter; • regular seminars and grand rounds at each institution; • marketing materials that highlight collaborative groups; • senior faculty with successful track records in team science research to

participating in and leading team science workshops (see Aim 3); and • hosting an annual Team Science Leadership meeting, aimed at Research

Deans, Department Chairs and Program Directors to discuss institutional resources for communication and data sharing, institutional policies regarding team science (promotion and tenure) and successful team processes.

C&C Evaluation MetricsEVALUATION METRICS: COMMUNITY AND COLLABORATION

Overall Aim and Objective Overall Evidence of success (Metrics)

AIM: To identify and respond to public health needs by fostering growth and productivity of effective teams of diverse stakeholders Objective: Form interdisciplinary teams with strong stakeholder engagement that lead to new and innovative translational research

1. # of grants that include investigators from multiple disciplines/departments and a minimum of one community stakeholder as key personnel (co-investigator).

2. Proportion of research project/grants with community stakeholder as key personnel

3. # of adopted clinical protocols that are direct result of collaborative (with stakeholder input) research

4. # of different “communities” that participate in design and conduct of research (not just as participants)

COMMUNITY AND COLLABORATION – AIM SPECIFIC Aims Measurable Objectives Implementation of strategies (Milestones) Evidence of Success (Metrics)

Aim 1: Create opportunities for multiple disciplines and communities to collaboratively produce research

1. Leverage partnerships through existing collaboratives

2. Support development of new research working groups

• Engage collaboratives in C&C objectives • Provide support for: collaborative meetings;

group goals/timelines; collaborative product development; pilot studies

• Develop action plan for team development • Monitor progress reports & milestones

• Action plan developed • # of new investigative teams • # collab. community grant proposals

leveraged (pubs., grants, toolkits) • % meeting milestones • # completed pilot studies

Aim 2: Build capacity for community/clinical collaborations via training & resources

1. Expand & strengthen partner capacity to do research and contribute to collaborative investigative teams

• Training in research methods & team science

• Support for team grant writing • Access to online library resources

• # organizations trained • Products resulting from community-

clinical team (paper, grants, protocols)

Aim 3: Build team science capacity among faculty, trainees, workforce and diverse community collaborators

1. Build new and strengthen existing investigative teams

2. Create & support team science success

3. Expand community involvement in team science

• Group team science training • Successful-team monthly seminars • Share best practices w/ T32 & K • Develop team training resources • Media highlights successful teams • Cultural competency training

• Academic-community teams that obtain grants

• # teams that obtain training • # team projects in media reports

(“ALT metrics”)

Aim 4: Facilitate institutional policy & environmental changes that encourage all aspects of team science

1. Disseminate team science P&T policy across medical center

2. Increase faculty-community scholarship & collaboration

• Promote implementation of team science P&T policy across new schools

• Faculty toolkit series on team science & evaluation

• Track and evaluate stakeholder engaged scholarship

• P&T policies adopted & implemented by professional schools

• # of team science faculty promoted or tenured.

• # faculty who identify stakeholders as (a) co-authors; (b) co-investigators; o (c) research partners

Questions for DiscussionWorkforce Development, Team Science and Stakeholder Engagement

1. How do you (or your Hub) define workforce? How do you (or your Hub) define a stakeholder?- this will provide us with understanding of similarities and -differences with our definitions as well as providing a context for interpreting the EAC members comments

2. What approach is your Hub using to encourage the development of interdisciplinary teams WITH stakeholder engagement? What challenges have you encountered?

Questions for DiscussionWorkforce Development, Team Science and Stakeholder Engagement

3. With your pilot grant program, what strategies are you using to move past the traditional T0-T1 groups coming forward into more transdisciplinary teams, focused on T3 or T4 translation?

4. How are you measuring impact in each of these areas: (1) workforce development; (2) pilot grants; (3) team science and (4) stakeholder engagement?

Breakout 1: Workforce Development, Team Science and Stakeholder EngagementWorkforce Development and PilotsSlide Number 3Slide Number 4Slide Number 5Slide Number 6Slide Number 7Slide Number 8Slide Number 9Slide Number 10Slide Number 11Slide Number 12Slide Number 13Team Science & Stakeholder EngagementCTSC RESOURCES TO SUPPORT C/T RESEARCHCOMMUNITY AND COLLABORATION TEAMThe Translational Science ContinuumDEFINING TRANSLATION IN 2018COMMUNITY….REDEFINEDOUR NEW FOCUSWhat is a Scientific Research Team?Who are the investigators on these teams?What (and whom) is a Stakeholder?Who are the Stakeholders?Our Goal: Promoting a Culture of Team Science with Stakeholder EngagementWhy Stakeholder Engagement is Important�Knowledge to Action (K2A) FrameworkSlide Number 27Knowledge to Action (K2A) FrameworkFOUR AIMS OF THE C&C COMPONENTAim 1: Developing Collaborative TeamsAim 1: Developing Collaborative TeamsSlide Number 32Aim 2: Building capacity of community and clinical partners to be translational partnersSlide Number 34Aim 3: Build capacity for team science among faculty, staff, students, and stakeholdersAim 4: Establishing Team Science with Stakeholder Engagement at a valued institutional normAim 4: Establishing Team Science with Stakeholder Engagement as a Valued Institutional NormAim 4: Establishing Team Science with Stakeholder Engagement as a Valued Institutional NormC&C Evaluation MetricsQuestions for Discussion�Workforce Development, Team Science and Stakeholder EngagementQuestions for Discussion�Workforce Development, Team Science and Stakeholder Engagement