dr. bhawna c reactive protein

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  • 8/19/2019 Dr. Bhawna c Reactive Protein

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    C REACTIVE PROTEIN

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    • CRP was discovered in Oswald Avery’s

    laboratory - Streptococcus pneumoniae infection.

    • CRP, named for its capacity to precipitate the

    somatic C-polysaccharide of Streptococcus  pneumoniae.

    •   The rst acute-phase protein to be described and is an important sensitive systemic marker of inammation and tissue damae.

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    • !onspecic "cute phase protien

    #evels rise in the body in responseto$

    o %nfection

    o

    %nammatory response o Tissue damae

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    &TR'CT'R( )* CRP

    • +elons to the pentraxin family of calcium dependent liand-bindin plasma proteins.

    •  The human CRP molecule is composed of ve identical nonlycosylated polypeptide

    subunits, each containin  amino acids.

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    Production

    •  This is the early and rapid host response to tissue in/ury.

    • #ocal e0pansion of pathoen number

    • 1irect activation of compliment in tissues.

    • 1eranulation of mast cells

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      Release of inammatory mediators

      &ystemically active mediators$

    2%#-3, %#-, T!*-45

      %nitiate production of CRP in liver

      "ctivation of C6(+P ene at transcri tion level

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    Release of CRP in circulation

    +inds with PHOSPHOCHOINE ! on bacterial cell wall and damaed eukaryotic cells. 

    • "ctivation of classical complimant pathway

    • %nteract with % receptors to activate %7

      P8"7)C9T)&%& )* +"CT(R%"6 1":"7(1 C(##&

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    • %n healthy youn adult the median concentration of CRP ;. m6l.

    • *ollowin an acute-phase stimulus, values may increase upto 3,-fold.

    • 8epatic synthesis starts very rapidly after a sinle stimulus.

    C#%!%C"# "PP#%C"T%)!

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    • &erum concentrations rise above < m6l by about  hours and peaks around => hours.

    •  The plasma half-life of CRP is about 3? hours and is constant under all conditions of health and disease.

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    C#%!%C"# '&(& )* CRP

    o &creenin infection6 inammation6tissue damae.

    )besity6 hypertension- risk of C81

    o  :onitorin of the response to treatment of inammation and infection.

    o 1etection of intercurrent infection in immunocompromised

    individuals.

    o 1ianosis of meninitis- bacterial6 viral by detection of CRP in C&*.

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    R"!7( )* CRP #(@(#&

    • @%R"# %!*(CT%)!&$ A=m6l

    +"CT(R%"# %!*(CT%)!&$ =- m6l

    • &(@(R( +"CT(R%"# %!*(CT%)!&6

     TR"':"6 +'R!&$ B m6l

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    #"+)R"T)R9 1(T(CT%)! )* CRP

    • #ate0 alutination test

    • 8s CRP  hih sensitivity CRP

    • %::'#%T( automated analyDer 21ianostic Product Corporation5 is a two-site chemiluminescent enDyme immunometric

    assay. with a detection limit of .3 m6#and a measurin rane of .3

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    • +!" nephelometer 21ade +ehrin5 by particle-enhanced immunonephelometry with a

    detection limit of .3> m6# and a measurin rane of .3>33

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