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  • 1. Burden of Rotavirus Disease &Impact of Rotavirus Vaccination TM Umesh D. Parashar, MBBS, MPH Lead, Viral Gastroenteritis Epidemiology Team Centers for Disease Control Prevention Atlanta, GA 1
  • 2. Rotavirus is the Leading Cause Of Severe Gastroenteritis in Children $1 B total 4CDC, MMWR, 2006
  • 5. Global Distribution of 527,000 Annual Rotavirus Deaths in Young Children 1 dot = 250 deaths 5Parashar et al, JID, 2009
  • 6. 2006 -- Phase 3 Trials of Two Rotavirus Vaccines Trials of 60-70,000 infants No increased risk of intussusception or other SAE Efficacy of 85%-98% against severe disease 6Vesikari et al and Ruiz-Palacios et al, NEJM 2006
  • 7. Countries in the Americas with Rotavirus Vaccine Programs Rotateq & Rotarix Rotarix only Rotateq only No program
  • 8. Rotavirus Vaccines in USA Feb 2006 RotaTeq recommended June 2008 Rotarix recommended 8
  • 9. National Rotavirus Laboratory Surveillance Network of 67 laboratories reporting since 2000 Weekly reporting: # specimens tested for rotavirus # positive tests
  • 10. Total and Positive RotavirusofTests, July 2000-Mar 2010 Total number of rotavirus tests and number positive test results* from 27 continuously reporting laboratories - National Respiratory and Enteric Virus Surveillance System, United States, July 2, 2000-February 20, 2010 800 Vaccine introduced Total no. tests 700 No. positive results 600 500Number 400 300 200 100 0 00 01 02 03 04 05 06 07 08 09 10 20 20 20 20 20 20 20 20 20 20 20 Month and year * 3-week moving averages Tate et al, Pediatrics 2009 and CDC unpublished data
  • 11. Active Rotavirus SurveillancePayne et al, PAS 2009 11
  • 12. Total AGE and Rotavirus AGE Hospitalizations NVSN, 2006-2008 Total AGE Rotavirus 200 181 179 180 160 139Number of cases 140 120 91 6% 100 81 Rota 80 50 % + 45 % Rota 60 + Rota + 40 20 9 0 2006 2007 2008 National reduction of 45,000-62,000 hospitalizations in 2008 12
  • 13. Age-Specific Rotavirus Hospitalization Rate Reduction and Vaccine Coverage, NVSN Age Decline in rotavirus Rotavirus vaccine hospitalization rate coverage in 2008 (2008 vs. 2006) (>=1 dose) < 1 year 66% 56%1 -< 2 years 95% 44%2 -< 3 years 85%