east african standard - eac-quality · pdf fileeast african standards are formulated in...

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CD/K/699:2010 ICS 67.120

© EAC 2010 First Edition 2010

EAST AFRICAN STANDARD Veterinary drugs residues in foods — Maximum residu e limits

EAST AFRICAN COMMUNITY

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CD/K/699:2010

ii © EAC 2010 — All rights reserved

Foreword Development of the East African Standards has been necessitated by the need for harmonizing requirements governing quality of products and services in East Africa. It is envisaged that through harmonized standardization, trade barriers which are encountered when goods and services are exchanged within the Community will be removed. In order to meet the above objectives, the EAC Partner States have enacted an East African Standardization, Quality Assurance, Metrology and Test Act, 2006 (EAC SQMT Act, 2006) to make provisions for ensuring standardization, quality assurance, metrology and testing of products produced or originating in a third country and traded in the Community in order to facilitate industrial development and trade as well as helping to protect the health and safety of society and the environment in the Community. East African Standards are formulated in accordance with the procedures established by the East African Standards Committee. The East African Standards Committee is established under the provisions of Article 4 of the EAC SQMT Act, 2006. The Committee is composed of representatives of the National Standards Bodies in Partner States, together with the representatives from the private sectors and consumer organizations. Draft East African Standards are circulated to stakeholders through the National Standards Bodies in the Partner States. The comments received are discussed and incorporated before finalization of standards, in accordance with the procedures of the Community. Article 15(1) of the EAC SQMT Act, 2006 provides that “Within six months of the declaration of an East African Standard, the Partner States shall adopt, without deviation from the approved text of the standard, the East African Standard as a national standard and withdraw any existing national standard with similar scope and purpose”.

East African Standards are subject to review, to keep pace with technological advances. Users of the East African Standards are therefore expected to ensure that they always have the latest versions of the standards they are implementing.

© East African Community 2010 — All rights reserved*

East African Community

P O Box 1096

Arusha

Tanzania

Tel: 255 27 2504253/8

Fax: 255-27-2504481/2504255

E-Mail: [email protected]

Web: www.each.int

* 2010 EAC — All rights of exploitation in any form and by any means reserved worldwide for EAC Partner States’ NSBs.

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CD/K/699:2010

© EAC 2010 — All rights reserved iii

Introduction In the preparation of this East African Standard, the following sources were consulted extensively: CAC/MRL 2:2009, Maximum Residue Limits for Veterinary Drugs in Food Codex Alimentarius website: http://www.codexalimentarius.net/mrls/pestdes/jsp/pest_q-e.jsp USDA Foreign Agricultural Service website: http://www.mrldatabase.com USDA Agricultural Marketing Service website: http://www.ams.usda.gov/AMSv1.0/Standards USDA Plant Inspectorate Service website: http://www.aphis.usda.gov/import_export/plants European Union: http://ec.europa.eu/sanco_pesticides/public Assistance derived from these sources is hereby acknowledged.

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CAC/MRL 02-2008 Page 1 of 32

Codex Alimentarius Commission

Maximum Residue Limits for Veterinary Drugs in Foods

Updated as at the 31st Session of the Codex Alimentarius Commission (July 2008)

INDEX

Veterinary Drug Page Veterinary Drug Page Abamectin 2 Flumequine 18 Albendazole 2 Gentamicin 19 Azaperone 2 Imidocarb 19 Benzylpenicillin/Procaine benzylpenicillin 3 Isometamidium 20 Carazolol 3 Ivermectin 20 Ceftiofur 4 Levamisole 21 Chlortetracycline/Oxytetracycline/Tetracycline 5 Lincomycin 22 Clenbuterol 6 Moxidectin 22 Closantel 7 Neomycin 23 Colistin 8 Nicarbazin 24 Cyfluthrin 9 Phoxim 24 Cyhalothrin 9 Pirlimycin 25 Cypermethrin and alpha-cypermethrin 10 Porcine somatotropin 25 Danofloxacin 10 Progesterone 26 Deltamethrin 11 Sarafloxacin 26 Diclazuril 12 Spectinomycin 27 Dyciclanil 12 Spiramycin 28 Dihydrostreptomycin/Streptomycin 13 Sulfadimidine 28 Diminazene 13 Testosterone 29 Doramectin 14 Thiabendazole 30 Eprinomectin 14 Tilmicosin 31 Erythromycin 15 Trenbolone acetate 31 Estradiol-17beta 15 Triclabendazole 32 Febantel/Fenbendazole/Oxfendazole 16 Trichlorfon (Metrifonate) 32 Fluazuron 17 Zeranol 32 Flubendazole 17

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Codex Alimentarius Commission

Maximum Residue Limits for Veterinary Drugs in Foods

Updated as at the 31st Session of the Codex Alimentarius Commission (July 2008)

ABAMECTIN (anthelmintic agent)

JECFA Evaluation: 45 (1995), 47 (1996) Acceptable Daily Intake : 0-2 µg/kg body weight (1997) Established for the sum of abamectin and (Z)-8,9

isomer by the 1997 JMPR. Residue Definition: Avermectin B1a.

Species Tissue MRL (µg/kg)

CAC Notes

Cattle Liver 100 26th (2003) Cattle Kidney 50 26th (2003) Cattle Fat 100 26th (2003)

ALBENDAZOLE (anthelmintic agent)

JECFA Evaluation: 34 (1989) Acceptable Daily Intake: 0-50 µg/kg body weight (34th JECFA, 1989). Residue Definition: Except milk, 2-aminosulfone metabolite; Milk, not yet identified.


CAC Notes

Not specified Muscle 100 20th (1993)

Not specified Liver 5000 20th (1993)

Not specified Kidney 5000 20th (1993)

Not specified Fat 100 20th (1993)

Not specified Milk (μg/l) 100 20th (1993)

AZAPERONE (tranquilizing agent)

JECFA Evaluation: 38 (1991), 43 (1994), 50 (1998), 52 (1999) Acceptable Daily Intake: 0-6 µg/kg body weight (50th JECFA, 1998). Residue Definition: Sum of azaperone and azaperol.


CAC Notes

Pig Muscle 60 23rd (1999)

Pig Liver 100 23rd (1999)

Pig Kidney 100 23rd (1999)

Pig Fat 60 23rd (1999)

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BENZYLPENICILLIN/PROCAINE BENZYLPENICILLIN (antimicrobial agent)

JECFA Evaluation: 36 (1990); 50 (1998) Acceptable Daily Intake: 30 µg-penicillin/person/day (50th JECFA, 1998). Residues of benzylpenicillin and

procaine benzylpenicillin should be kept below this level. Residue Definition: Benzylpenicillin.


CAC Notes

Cattle Muscle 50 23rd (1999)

Cattle Liver 50 23rd (1999)

Cattle Kidney 50 23rd (1999)

Cattle Milk (μg/l) 4 23rd (1999)

Chicken Muscle 50 23rd (1999) Applies to procaine benzylpenicillin only.

Chicken Liver 50 23rd (1999) Applies to procaine benzylpenicillin only.

Chicken Kidney 50 23rd (1999) Applies to procaine benzylpenicillin only.




CARAZOLOL (beta-adreniceptor-blocking agent)

JECFA Evaluation: 38 (1991), 43 (1994), 52 (1999) Acceptable Daily Intake: 0-0.1 µg/kg body weight (43rd JECFA, 1994). ADI based on the acute

pharmacological effects of carazolol. Residue Definition: Carazolol.


CAC Notes

Pig Muscle 5 26th (2003) The concentration at the injection site two hours after treatment may result in an intake that exceeds the acute RfD and therefore, an appropriate withdrawal period should be applied.

Pig Liver 25 26th (2003)

Pig Kidney 25 26th (2003)

Pig Fat/Skin 5 26th (2003) The concentration at the injection site two hours after treatment may result in an intake that exceeds the acute RfD and therefore, an appropriate withdrawal period should be applied.

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CEFTIOFUR (antimicrobial agent)

JECFA Evaluation: 45 (1995), 48 (1997) Acceptable Daily Intake: 0-50 µg/kg body weight (45th JECFA, 1995). Residue Definition: Desfuroylceftiofur.


CAC Notes




Cattle Fat 2000 23rd (1999)



Pig Liver 2000 23rd (1999)


Pig Fat 2000 23rd (1999)

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CHLORTETRACYCLINE/OXYTETRACYCLINE/TETRACYCLINE (antimicrobial agent)

JECFA Evaluation: 45 (1995), 47 (1996), 50 (1998) Acceptable Daily Intake: 0-30 µg/kg body weight (50th JECFA, 1998). Group ADI for chlortetracycline,

oxytetracycline and tetracycline. Residue Definition: Parent drugs, singly or in combination.


CAC Notes

Cattle Muscle 200 26th (2003)

Cattle Liver 600 26th (2003)

Cattle Kidney 1200 26th (2003)

Cattle Milk (μg/l) 100 26th (2003)

Fish Muscle 200 26th (2003) Applies only to oxytetracycline.

Giant prawn (Paeneus monodon)

Muscle 200 26th (2003) Applies only to oxytetracycline.

Pig Muscle 200 26th (2003)



Poultry Muscle 200 26th (2003)

Poultry Liver 600 26th (2003)

Poultry Kidney 1200 26th (2003)

Poultry Eggs 400 26th (2003)

Sheep Muscle 200 26th (2003)

Sheep Liver 600 26th (2003)

Sheep Kidney 1200 26th (2003)

Sheep Milk (μg/l) 100 26th (2003)

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CLENBUTEROL (adrenoceptor agonist)

JECFA Evaluation: 47 (1996) Acceptable Daily Intake: 0-0.004 µg/kg body weight (47th JECFA, 1996). Residue Definition: Clenbuterol.


CAC Notes

Cattle Muscle 0.2 26th (2003) Due to the potential abuse of this drug, the MRLs are recommended only when associated with a nationally approved therapeutic use, such as tocolysis or as an adjunt therapy in respiratory diseases.

Cattle Liver 0.6 26th (2003) Due to the potential abuse of this drug, the MRLs are recommended only when associated with a nationally approved therapeutic use, such as tocolysis or as an adjunt therapy in respiratory diseases.

Cattle Kidney 0.6 26th (2003) Due to the potential abuse of this drug, the MRLs are recommended only when associated with a nationally approved therapeutic use, such as tocolysis or as an adjunt therapy in respiratory diseases.

Cattle Fat 0.2 26th (2003) Due to the potential abuse of this drug, the MRLs are recommended only when associated with a nationally approved therapeutic use, such as tocolysis or as an adjunt therapy in respiratory diseases.

Cattle Milk (μg/l) 0.05 26th (2003) Due to the potential abuse of this drug, the MRLs are recommended only when associated with a nationally approved therapeutic use, such as tocolysis or as an adjunt therapy in respiratory diseases.

Horse Muscle 0.2 26th (2003) Due to the potential abuse of this drug, the MRLs are recommended only when associated with a nationally approved therapeutic use, such as tocolysis or as an adjunt therapy in respiratory diseases.

Horse Liver 0.6 26th (2003) Due to the potential abuse of this drug, the MRLs are recommended only when associated with a nationally approved therapeutic use, such as tocolysis or as an adjunt therapy in respiratory diseases.

Horse Kidney 0.6 26th (2003) Due to the potential abuse of this drug, the MRLs are recommended only when associated with a nationally approved therapeutic use, such as tocolysis or as an adjunt therapy in respiratory diseases.

Horse Fat 0.2 26th (2003) Due to the potential abuse of this drug, the MRLs are recommended only when associated with a nationally approved therapeutic use, such as tocolysis or as an adjunt therapy in respiratory diseases.

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CLOSANTEL (anthelmintic agent)

JECFA Evaluation: 36 (1990), 40 (1992) Acceptable Daily Intake: 0-30 µg/kg body weight (40th JECFA, 1992). Residue Definition: Closantel.


CAC Notes




Cattle Fat 3000 20th (1993)




Sheep Fat 2000 20th (1993)

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COLISTIN (antimicrobial agent)

JECFA Evaluation: 66 (2006) Acceptable Daily Intake: 0-7 µg/kg body weight (66th JECFA, 2006). Residue Definition: Sum of colistin A and colistin B.


CAC Notes

Cattle Muscle 150 31st (2008)

Cattle Liver 150 31st (2008)

Cattle Kidney 200 31st (2008)

Cattle Fat 150 31st (2008)

Cattle Milk 50 31st (2008)

Sheep Muscle 150 31st (2008)

Sheep Liver 150 31st (2008)

Sheep Kidney 200 31st (2008)

Sheep Fat 150 31st (2008)

Sheep Milk 50 31st (2008)

Goat Muscle 150 31st (2008)

Goat Liver 150 31st (2008)

Goat Kidney 200 31st (2008)

Goat Fat 150 31st (2008)

Pig Muscle 150 31st (2008)

Pig Liver 150 31st (2008)

Pig Kidney 200 31st (2008)

Pig Fat 150 31st (2008) The MRL includes skin + fat

Chicken Muscle 150 31st (2008)

Chicken Liver 150 31st (2008)

Chicken Kidney 200 31st (2008)

Chicken Fat 150 31st (2008) The MRL includes skin + fat

Chicken Eggs 300 31st (2008)

Turkey Muscle 150 31st (2008)

Turkey Liver 150 31st (2008)

Turkey Kidney 200 31st (2008)

Turkey Fat 150 31st (2008) The MRL includes skin + fat

Rabbit Muscle 150 31st (2008)

Rabbit Liver 150 31st (2008)

Rabbit Kidney 200 31st (2008)

Rabbit Fat 150 31st (2008)

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CYFLUTHRIN (insecticide)

JECFA Evaluation: 48 (1997) Acceptable Daily Intake: 0-20 µg/kg body weight (48th JECFA, 1997). Residue Definition: Cyfluthrin.


CAC Notes






CYHALOTHRIN (insecticide)

JECFA Evaluation: 54 (2000); 62 (2004) Acceptable Daily Intake: 0-5 µg/kg body weight (62nd JECFA, 2004). Residue Definition: Cyhalothrin.


CAC Notes





Cattle Milk 30 28th (2005)




Pig Fat 400 28th (2005)




Sheep Fat 400 28th (2005)

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CYPERMETHRIN AND ALPHA-CYPERMETHRIN (insecticide)

JECFA Evaluation: 62 (2004) Acceptable Daily Intake: JECFA established a common ADI of 0-20 µg/kg bw for both cypermethrin and

alpha-cypermethrin.

Residue Definition: Total of cypermethrin residues (resulting from the use of cypermethrin or alpha-cypermethrin as veterinary drugs).

Species Tissue MRLs(µg/kg) CAC Note









Sheep Fat 1000 29th (2006)

DANOFLOXACIN (antimicrobial agent)

JECFA Evaluation: 48 (1997) Acceptable Daily Intake: 0-20 µg/kg body weight (48th JECFA, 1997). Residue Definition: Danofloxacin.


CAC Notes





Chicken Muscle 200 24th (2001)

Chicken Liver 400 24th (2001)

Chicken Kidney 400 24th (2001)

Chicken Fat 100 24th (2001) Fat/skin in normal proportion.




Pig Fat 100 24th (2001)

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DELTAMETHRIN (insecticide)

JECFA Evaluation: 52 (1999), 60 (2003) Acceptable Daily Intake: 0-10 µg/kg body weight (1982). Established by the 1982 JMPR. Residue Definition: Deltamethrin.


CAC Notes









Chicken Fat 500 26th (2003)

Chicken Eggs 30 26th (2003)

Salmon Muscle 30 26th (2003)





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DICLAZURIL (antiprotozoal agent)

JECFA Evaluation: 45 (1995), 50 (1998) Acceptable Daily Intake: 0-30 µg/kg body weight (50th JECFA, 1998). Residue Definition: Diclazuril.


CAC Notes

Poultry Muscle 500 23rd (1999)

Poultry Liver 3000 23rd (1999)

Poultry Kidney 2000 23rd (1999)

Poultry Fat/Skin 1000 23rd (1999)

Rabbit Muscle 500 23rd (1999)

Rabbit Liver 3000 23rd (1999)

Rabbit Kidney 2000 23rd (1999)

Rabbit Fat 1000 23rd (1999)

Sheep Muscle 500 23rd (1999)

Sheep Liver 3000 23rd (1999)

Sheep Kidney 2000 23rd (1999)

Sheep Fat 1000 23rd (1999)

DICYCLANIL (insecticide)

JECFA Evaluation: 54 (2000), 60 (2003) Acceptable Daily Intake: 0-7 µg/kg body weigh (54th JECFA, 2000). Residue Definition: Dicyclanil.


CAC Notes





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DIHYDROSTREPTOMYCIN/STREPTOMYCIN (antimicrobial agent)

JECFA Evaluation: 43 (1994), 48 (1997), 52 (1999), 58 (2002) Acceptable Daily Intake: 0-50 µg/kg body weight (48th JECFA, 1997). Group ADI for combined residues of

dihydrostreptomycin and streptomycin. Residue Definition: Sum of dihydrostreptomycin and streptomycin.


CAC Notes













Pig Fat 600 24th (2001)





Sheep Milk 200 26th (2003)

DIMINAZENE (trypanocide)

JECFA Evaluation: 34 (1989), 42 (1994) Acceptable Daily Intake: 0-100 µg/kg body weight (42nd JECFA, 1994). Residue Definition: Diminazene.


CAC Notes

Cattle Muscle 500 22nd (1997)

Cattle Liver 12000 22nd (1997)

Cattle Kidney 6000 22nd (1997)

Cattle Milk (μg/l) 150 22nd (1997) Limit of quantitation of the analytical method.

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DORAMECTIN (anthelmintic agent)

JECFA Evaluation: 45 (1995), 52 (1999), 62 (2004) Acceptable Daily Intake: 0-0.5 µg/kg body weight (45th JECFA, 1995). Residue Definition: Doramectin.


CAC Notes

Cattle Muscle 10 22nd (1997) High concentration of residues at the injection site over a 35 day period after subcutaneous or intramuscular administration of the drug at the recommended dose.



Cattle Fat 150 22nd (1997) High concentration of residues at the injection site over a 35 day period after subcutaneous or intramuscular administration of the drug at the recommended dose

Cattle Lait 15 29th (2006) Depending on the route and/or time of administration the use of doramectin in dairy cows may result in extended withdrawal periods in milk. This may be addressed in national/regional regulatory programmes.




Pig Fat 150 24th (2001)

EPRINOMECTIN (anthelmintic agent)

JECFA Evaluation: 50 (1998) Acceptable Daily Intake: 0-10 µg/kg body weight (50th JECFA, 1998). Residue Definition: Eprinomectin B1a.


CAC Notes






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ERYTHROMYCIN (antimicrobial agent)

JECFA Evaluation: 66 (2006) Acceptable Daily Intake: 0-0.7 µg/kg body weight (66th JECFA, 2006). Residue Definition: Erythromycin A


CAC Notes

Chicken Muscle 100 31st (2008)

Chicken Liver 100 31st (2008)

Chicken Kidney 100 31st (2008)

Chicken Fat 100 31st (2008) The MRL includes skin + fat

Chicken Eggs 50 31st (2008)

Turkey Muscle 100 31st (2008)

Turkey Liver 100 31st (2008)

Turkey Kidney 100 31st (2008)

Turkey Fat 100 31st (2008) The MRL includes skin + fat

ESTRADIOL-17BETA (production aid)

JECFA Evaluation: 25 (1981), 32 (1987), 52 (1999) Acceptable Daily Intake: unnecessary (32nd JECFA, 1987); 0-0.05 µg/kg body weight (52nd JECFA, 1999). Residue Definition: Estradiol-17beta.


CAC Notes

Cattle Muscle unnecessary 21st (1995) Residues resulting from the use of this substances as a growth promoter in accordance with good animal husbandry practice are unlikely to pose a hazard to human health.

Cattle Liver unnecessary 21st (1995) Residues resulting from the use of this substances as a growth promoter in accordance with good animal husbandry practice are unlikely to pose a hazard to human health.

Cattle Kidney unnecessary 21st (1995) Residues resulting from the use of this substances as a growth promoter in accordance with good animal husbandry practice are unlikely to pose a hazard to human health.

Cattle Fat unnecessary 21st (1995) Residues resulting from the use of this substances as a growth promoter in accordance with good animal husbandry practice are unlikely to pose a hazard to human health.

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FEBANTEL/FENBENDAZOLE/OXFENDAZOLE (anthelmintic agent)

JECFA Evaluation: 38 (1991), 45 (1995), 50 (1998) Acceptable Daily Intake: 0-7 µg/kg body weight (50th JECFA, 1998). Group ADI Residue Definition: Sum of fenbendazole, oxfendazole and oxfendazole sulphone, expressed as

oxfendazole sulphone equivalents.


CAC Notes






Goat Muscle 100 23rd (1999)

Goat Liver 500 23rd (1999)

Goat Kidney 100 23rd (1999)

Goat Fat 100 23rd (1999)

Horse Muscle 100 23rd (1999)

Horse Liver 500 23rd (1999)

Horse Kidney 100 23rd (1999)

Horse Fat 100 23rd (1999)




Pig Fat 100 23rd (1999)




Sheep Fat 100 23rd (1999)

Sheep Milk (μg/l) 100 23rd (1999)

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FLUAZURON (insecticide)

JECFA Evaluation: 48 (1997) Acceptable Daily Intake: 0-40 µg/kg body weight (48th JECFA, 1997). Residue Definition: Fluazuron.


CAC Notes





FLUBENDAZOLE (anthelmintic agent)

JECFA Evaluation: 40 (1992) Acceptable Daily Intake: 0-12 µg/kg body weight (40th JECFA, 1992). Residue Definition: Flubendazole.


CAC Notes

Pig Muscle 10 21st (1995)

Pig Liver 10 21st (1995)

Poultry Muscle 200 21st (1995)

Poultry Liver 500 21st (1995)

Poultry Eggs 400 21st (1995)

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FLUMEQUINE (antimicrobial agent)

JECFA Evaluation: 42 (1994), 48 (1997), 54 (2000), 60 (2002), 62 (2004), 66 (2006) Acceptable Daily Intake: 0-30 µg/kg body weight (62nd JECFA, 2004). Residue Definition: Flumequine.


CAC Notes












Pig Fat 1000 28th (2005)




Sheep Fat 1000 28th (2005)

Trout Muscle 500 28th (2005) Muscle including normal proportion of skin

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GENTAMICIN (antimicrobial agent)

JECFA Evaluation: 43 (1994), 48 (1997), 50 (1998) Acceptable Daily Intake: 0-20 µg/kg body weight (50th JECFA, 1998). Residue Definition: Gentamicin.


CAC Notes







Pig Liver 2000 24th (2001)


Pig Fat 100 24th (2001)

IMIDOCARB (antiprotozoal agent)

JECFA Evaluation: 50 (1998), 60 (2003) Acceptable Daily Intake: 0-10 µg/kg body weight (50th JECFA, 1998). Residue Definition: Imidocarb.


CAC Notes






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ISOMETAMIDIUM (trypanocide)

JECFA Evaluation: 34 (1989); 40 (1992) Acceptable Daily Intake: 0-100 µg/kg body weight (40th JECFA, 1992). Residue Definition: Isometamidium.


CAC Notes

Cattle Muscle 100 21st (1995)

Cattle Liver 500 21st (1995)

Cattle Kidney 1000 21st (1995)

Cattle Fat 100 21st (1995)

Cattle Milk (μg/l) 100 21st (1995)

IVERMECTIN (anthelmintic agent)

JECFA Evaluation: 36 (1990), 40 (1992), 54 (2000), 58 (2002) Acceptable Daily Intake: 0-1 µg/kg body weight (40th JECFA, 1992). Residue Definition: 22,23-Dihydroavermectin B1a (H2B1a).


CAC Notes





Pig Fat 20 20th (1993)



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LEVAMISOLE (anthelmintic agent)

JECFA Evaluation: 36 (1990), 42 (1994) Acceptable Daily Intake: 0-6 µg/kg body weight (42nd JECFA, 1994). Residue Definition: Levamisole.


CAC Notes




Cattle Fat 10 22nd (1997)

Pig Muscle 10 22nd (1997)

Pig Liver 100 22nd (1997)

Pig Kidney 10 22nd (1997)

Pig Fat 10 22nd (1997)

Poultry Muscle 10 22nd (1997)

Poultry Liver 100 22nd (1997)

Poultry Kidney 10 22nd (1997)

Poultry Fat 10 22nd (1997)

Sheep Muscle 10 22nd (1997)

Sheep Liver 100 22nd (1997)

Sheep Kidney 10 22nd (1997)

Sheep Fat 10 22nd (1997)

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LINCOMYCIN (antimicrobial agent)

JECFA Evaluation: 54 (2000), 58 (2002); 62 (2004) Acceptable Daily Intake: 0-30 µg/kg body weight (54th JECFA, 2000). Residue Definition: Lincomycin.


CAC Notes





Chicken Fat 100 26th (2003) Additional MRL for skin with adhering fat of 300 μg/kg.




Pig Fat 100 26th (2003) Additional MRL for skin with adhering fat of 300 μg/kg.

MOXIDECTIN (anthelmintic agent)

JECFA Evaluation: 45 (1995), 47 (1996), 48 (1998), 50 (1998) Acceptable Daily Intake: 0-2 µg/kg body weight (45th JECFA, 1995). Residue Definition: Moxidectin.


CAC Notes

Cattle Muscle 20 22nd (1997) Very high concentration and great variation in the level of residues at the injection site in cattle over a 49 day period after dosing.




Deer Muscle 20 23rd (1999)

Deer Liver 100 23rd (1999)

Deer Kidney 50 23rd (1999)

Deer Fat 500 23rd (1999)

Sheep Muscle 50 22nd (1997)

Sheep Liver 100 22nd (1997)

Sheep Kidney 50 22nd (1997)

Sheep Fat 500 22nd (1997)

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NEOMYCIN (antimicrobial agent)

JECFA Evaluation: 43 (1994), 47 (1996), 52 (1999); 58 (2002); 60 (2003) Acceptable Daily Intake: 0-60 µg/kg body weight (47th JECFA, 1996). Residue Definition: Neomycin.


CAC Notes






Chicken Muscle 500 23rd (1999)

Chicken Liver 500 23rd (1999)

Chicken Kidney 10000 23rd (1999)

Chicken Fat 500 23rd (1999)

Chicken Eggs 500 23rd (1999)

Duck Muscle 500 23rd (1999)

Duck Liver 500 23rd (1999)

Duck Kidney 10000 23rd (1999)

Duck Fat 500 23rd (1999)

Goat Muscle 500 23rd (1999)

Goat Liver 500 23rd (1999)

Goat Kidney 10000 23rd (1999)

Goat Fat 500 23rd (1999)



Pig Kidney 10000 23rd (1999)

Pig Fat 500 23rd (1999)




Sheep Fat 500 23rd (1999)

Turkey Muscle 500 23rd (1999)

Turkey Liver 500 23rd (1999)

Turkey Kidney 10000 23rd (1999)

Turkey Fat 500 23rd (1999)

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NICARBAZIN (antiprotozoal agent)

JECFA Evaluation: 50 (1998) Acceptable Daily Intake: 0-400 µg/kg body weight (50th JECFA, 1998). Residue Definition: N,N'-bis(4-nitropheyl)urea.


CAC Notes

Chicken Muscle 200 23rd (1999) Broilers. Chicken Liver 200 23rd (1999) Broilers. Chicken Kidney 200 23rd (1999) Broilers. Chicken Fat/Skin 200 23rd (1999) Broilers.

PHOXIM (insecticide)

JECFA Evaluation: 52 (1999), 62 (2004) Acceptable Daily Intake: 0-4 µg/kg body weight (52nd JECFA, 1999). Residue Definition: Phoxim


CAC Notes

Goat Muscle 50 26th (2003)

Goat Liver 50 26th (2003)

Goat Kidney 50 26th (2003)

Goat Fat 400 26th (2003)




Pig Fat 400 26th (2003)





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PIRLIMYCIN (antimicrobial agent)

JECFA Evaluation: 62 (2004) Acceptable Daily Intake: 0-8 µg/kg bw (62nd JECFA, 2004).

Residue Definition: Pirlimycin.

Species Tissue MRLs(µg/kg) CAC Note





Cattle Milk 100 29th (2006) JECFA evaluated the effect of pirlimycin residues on starter cultures and for this reason recommended an MRL of 100 µg/kg of milk. Codex Members may therefore adapt national/regional MRLs in order to address this technological aspect for trade of fresh liquid milk intended for processing using starter culture.

PORCINE SOMATOTROPIN (production aid) JECFA Evaluation: 52 (1999) Acceptable Daily Intake: Not Specified (52nd JECFA, 1999). Residue Definition: Not applicable.


CAC Notes

Pig Muscle not specified 26th (2003)

Pig Liver not specified 26th (2003)

Pig Kidney not specified 26th (2003)

Pig Fat not specified 26th (2003)

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PROGESTERONE (production aid)

JECFA Evaluation: 25 (1981), 32 (1987), 52 (1999) Acceptable Daily Intake: 0-30 µg/kg body weight (52nd JECFA, 1999). Residue Definition: Progesterone.


CAC Notes

Cattle Muscle unnecessary 21st (2005) Residues resulting from the use of this substances as a growth promoter in accordance with good animal husbandry practice are unlikely to pose a hazard to human health

Cattle Liver unnecessary 21st (2005) Residues resulting from the use of this substances as a growth promoter in accordance with good animal husbandry practice are unlikely to pose a hazard to human health

Cattle Kidney unnecessary 21st (2005) Residues resulting from the use of this substances as a growth promoter in accordance with good animal husbandry practice are unlikely to pose a hazard to human health

Cattle Fat unnecessary 21st (2005) Residues resulting from the use of this substances as a growth promoter in accordance with good animal husbandry practice are unlikely to pose a hazard to human health

SARAFLOXACIN (antimicrobial agent)

JECFA Evaluation: 50 (1998) Acceptable Daily Intake: 0-0.3 µg/kg body weight (50th JECFA, 1998). Residue Definition: Sarafloxacin.


CAC Notes

Chicken Muscle 10 24th (2001) Chicken Liver 80 24th (2001)



Turkey Muscle 10 24th (2001)

Turkey Liver 80 24th (2001)

Turkey Kidney 80 24th (2001)

Turkey Fat 20 24th (2001)

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SPECTINOMYCIN (antimicrobial agent)

JECFA Evaluation: 42 (1994), 50 (1998) Acceptable Daily Intake: 0-40 µg/kg body weight (42nd JECFA, 1994). Residue Definition: Spectinomycin.


CAC Notes






Chicken Muscle 500 23rd (1999)

Chicken Liver 2000 23rd (1999)

Chicken Kidney 5000 23rd (1999)

Chicken Fat 2000 23rd (1999)

Chicken Eggs 2000 23rd (1999)


Pig Liver 2000 23rd (1999)


Pig Fat 2000 23rd (1999)




Sheep Fat 2000 23rd (1999)

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SPIRAMYCIN (antimicrobial agent)

JECFA Evaluation: 38 (1991), 43 (1994), 47 (1996), 48 (1997) Acceptable Daily Intake: 0-50 µg/kg body weight (43rd JECFA, 1994). Residue Definition: Cattle and chickens, sum of spiramycin and neospiramycin; Pigs, spiramycin

equivalents (antimicrobially active residues).


CAC Notes





Cattle Milk (μg/l) 200 22nd (1997)

Chicken Muscle 200 22nd (1997)

Chicken Liver 600 22nd (1997)

Chicken Kidney 800 22nd (1997)

Chicken Fat 300 22nd (1997)

Pig Muscle 200 22nd (1997)

Pig Liver 600 22nd (1997)

Pig Kidney 300 22nd (1997)

Pig Fat 300 22nd (1997)

SULFADIMIDINE (antimicrobial agent)

JECFA Evaluation: 34 (1989), 38 (1991), 42 (1994) Acceptable Daily Intake: 0-50 µg/kg body weight (42nd JECFA, 1994). Residue Definition: Sulfadimidine.


CAC Notes

Cattle Milk (μg/l) 25 21st (1995)

Not specified Muscle 100 21st (1995)

Not specified Liver 100 21st (1995)

Not specified Kidney 100 21st (1995)

Not specified Fat 100 21st (1995)

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TESTOSTERONE (production aid)

JECFA Evaluation: 25 (1981), 32 (1987), 52 (1999) Acceptable Daily Intake: 0-2 µg/kg body weight (52nd JECFA, 1999). Residue Definition: Testosterone.


CAC Notes

Cattle Muscle unnecessary 21st (1995) Residues resulting from the use of this substances as a growth promoter in accordance with good animal husbandry practice are unlikely to pose a hazard to human health.

Cattle Liver unnecessary 21st (1995) Residues resulting from the use of this substances as a growth promoter in accordance with good animal husbandry practice are unlikely to pose a hazard to human health.

Cattle Kidney unnecessary 21st (1995) Residues resulting from the use of this substances as a growth promoter in accordance with good animal husbandry practice are unlikely to pose a hazard to human health.

Cattle Fat unnecessary 21st (1995) Residues resulting from the use of this substances as a growth promoter in accordance with good animal husbandry practice are unlikely to pose a hazard to human health.

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THIABENDAZOLE (anthelmintic agent)

JECFA Evaluation: 40 (1992), 48 (1997); 58 (2002) Acceptable Daily Intake: 0-100 µg/kg body weight (40th JECFA, 1992). Residue Definition: Sum of thiabendazole and 5-hydroxythiabendazole.


CAC Notes

Cattle Muscle 100 21st (1995) The MRL also covers residues derived from feed containing the residues resulted from agricultural use.

Cattle Liver 100 21st (1995) The MRL also covers residues derived from feed containing the residues resulted from agricultural use.

Cattle Kidney 100 21st (1995) The MRL also covers residues derived from feed containing the residues resulted from agricultural use.

Cattle Fat 100 21st (1995) The MRL also covers residues derived from feed containing the residues resulted from agricultural use.

Cattle Milk (μg/l)

100 21st (1995) The MRL also covers residues derived from feed containing the residues resulted from agricultural use.

Goat Muscle 100 21st (1995) The MRL also covers residues derived from feed containing the residues resulted from agricultural use.

Goat Liver 100 21st (1995) The MRL also covers residues derived from feed containing the residues resulted from agricultural use.

Goat Kidney 100 21st (1995) The MRL also covers residues derived from feed containing the residues resulted from agricultural use.

Goat Fat 100 21st (1995) The MRL also covers residues derived from feed containing the residues resulted from agricultural use.

Goat Milk (μg/l)

100 21st (1995) The MRL also covers residues derived from feed containing the residues resulted from agricultural use.

Pig Muscle 100 21st (1995) The MRL also covers residues derived from feed containing the residues resulted from agricultural use.

Pig Liver 100 21st (1995) The MRL also covers residues derived from feed containing the residues resulted from agricultural use.

Pig Kidney 100 21st (1995) The MRL also covers residues derived from feed containing the residues resulted from agricultural use.

Pig Fat 100 21st (1995) The MRL also covers residues derived from feed containing the residues resulted from agricultural use.

Sheep Muscle 100 21st (1995) The MRL also covers residues derived from feed containing the residues resulted from agricultural use.

Sheep Liver 100 21st (1995) The MRL also covers residues derived from feed containing the residues resulted from agricultural use.

Sheep Kidney 100 21st (1995) The MRL also covers residues derived from feed containing the residues resulted from agricultural use.

Sheep Fat 100 21st (1995) The MRL also covers residues derived from feed containing the residues resulted from agricultural use.

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TILMICOSIN (antimicrobial agent)

JECFA Evaluation: 47 (1996), 54 (2000) Acceptable Daily Intake: 0-40 µg/kg body weight (47th JECFA, 1996). Residue Definition: Tilmicosin.


CAC Notes

Cattle Muscle 100 23rd (1999) Cattle Liver 1000 23rd (1999) Cattle Kidney 300 23rd (1999) Cattle Fat 100 23rd (1999) Pig Muscle 100 23rd (1999) Pig Liver 1500 23rd (1999) Pig Kidney 1000 23rd (1999) Pig Fat 100 23rd (1999) Sheep Muscle 100 23rd (1999) Sheep Liver 1000 23rd (1999) Sheep Kidney 300 23rd (1999) Sheep Fat 100 23rd (1999) Sheep Milk (μg/l) 50T 23rd (1999) The 54th JECFA did not extend the temporary MRL for

tilmicosin in ewes’s milk recommended at its 47th meeting because the requested information on the results of a study with radiolabelled drug in lactating ewes to determine the relationship between total residues and parent drug in milk, was not submitted.

TRENBOLONE ACETATE (growth promoter)

JECFA Evaluation: 26 (1982), 27 (1983), 32 (1987), 34 (1989) Acceptable Daily Intake: 0-0.02 µg/kg body weight (34th JECFA, 1989).

Residue Definition: Cattle muscle, beta-Trenbolone; Cattle liver, alpha-Trenbolone.


CAC Notes

Cattle Muscle 2 21st (1995) Cattle Liver 10 21st (1995)

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TRICLABENDAZOLE (anthelmintic agent)

JECFA Evaluation: 40 (1992); 66 (2006) Acceptable Daily Intake: 0-3 µg/kg body weight (40th JECFA, 1992).

Residue Definition: 5-Chloro-6-(2',3'-dichlorophenoxy)-benzimidazole-2-one.


CAC Notes


Cattle Liver 300 22nd (1997) Cattle Kidney 300 22nd (1997) Cattle Fat 100 22nd (1997) Sheep Muscle 100 22nd (1997) Sheep Liver 100 22nd (1997) Sheep Kidney 100 22nd (1997) Sheep Fat 100 22nd (1997)

TRICHLORFON (METRIFONATE) (insecticide) JECFA Evaluation: 54 (2000); 60 (2003) Acceptable Daily Intake: 0-2 µg/kg bw (60th JECFA, 2003)

Residue Definition: JECFA confirmed the MRL for cows’s milk and the guidance levels for muscle, liver, kidney and fat of cattle recommended at the 54th meeting (WHO TRS 900, 2001)

Species Tissue MRLs(µg/kg) CAC Notes


ZERANOL (growth promoter)

JECFA Evaluation: 26 (1982), 27 (1983), 32 (1987) Acceptable Daily Intake : 0-0.5 µg/kg body weight (32nd JECFA, 1987).

Residue Definition: Zeranol.


CAC Notes

Cattle Muscle 2 21st (1995) Cattle Liver 10 21st (1995)

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