ElectrophysiologySelected by Paul Wang, Affinity Lead

I selected Marco Perez and Mintu Turakhia to be highlighted in this newsletter. Over a decade as faculty in the Stanford Cardiovascular Medicine Division, Marco and Mintu have made remarkable accomplishments in our field and have established themselves as international leaders in both research and clinical medicine. Together they led the Apple Heart Study, a pioneering virtual study with over 400,000 enrolled participants reporting that wearable devices can detect heart irregularities and atrial fibrillation.

Dr. Marco Perez is an Associate Professor of Medicine at Stanford University and is a clinical cardiac electrophysiologist. He is director of the Inherited Cardiac Arrhythmia Clinic which he established 10 years ago where he cares for families with rare inherited arrhythmic conditions such as Long QT and Brugada syndromes and other arrhythmic diseases in young patients and in athletes. His research goal is to better understand the fundamental causes of cardiovascular disease through the study of genetics and epidemiology.

He was awarded NIH R01 funding to run WHISH-STAR, a large randomized study of the effects of exercise intervention on atrial fibrillation. This nation-wide study in older women uses electrocardiographic patch monitors to screen for previously undiagnosed arrhythmic disease. He is also co-Principal Investigator for the Apple Heart Study, which enrolled over 400,000 participants in a virtual study using the Apple Watch to identify irregular pulse consistent with atrial fibrillation. He also receives funding from the Stanford SPARK program and the Weston Havens foundation to develop a small molecule agonist of HCRTR2, a novel therapeutic target he and colleagues identified using systems-genomic tools, for the treatment of heart failure.

Dr. Perez is excited about exploring the expanding role of genetic testing in the clinical setting, the growing use of wearable technology to screen for cardiovascular disease and the use of virtual study designs to conduct large-scale clinical studies. Dr. Mintu Turakhia is an Associate Professor of Medicine. He is director of the electrophysiology program at the VA Palo Alto Health Care System. After training at Brigham and Women’s Hospital and UCSF, he came to Stanford in 2008 and developed a multidisciplinary program in heart rhythm research that applies biostatistical, health economic, and data science approaches to examine quality, outcomes, and risk of heart rhythm disorders such as atrial fibrillation in very large datasets that his group has assembled.

THURSDAY, JULY 18, 2019

Hearty NewsQuarterly Cardiovascular Medicine Newsletter

Summer 2019

Faculty Spotlight

To further extend this work into wearables and technology-based clinical trials, Mintu co-founded the Stanford Center for Digital Health and has served as its executive director since 2017. The center leads technology research, education, and strategic partnerships with pharmaceutical, device, and technology companies. Mintu has served as PI of several multi-center arrhythmia technology trials, includingSmartADHERE and AMBULATE, and he is co-PI of the Apple Heart Study with Dr. Marco Perez. Mintu has authored over 200 manuscripts and other works including 15 national or international guidelines. He is an elected member of the American Society of Clinical Investigation and is an Associate Editor of JAMA Cardiology.

Mintu enjoys skiing, golfing, the data science of sports, and crafting obscure cocktails.

Appointments and Promotions

Faculty

Reappointments

Staff

New appointments

Sanjiv Narayan MD was reappointed to Professor (Cardiovascular Medicine) on May 1, 2019.

Juyong (Brian) Kim MD was reappointed to Instructor (Cardiovascular Medicine) on July 1, 2019.

Marina Romero, Administrative Associate, is supporting the General Cardiology and VA cardiology group. Marina started on April 29th.

Young Kim, Software Developer, is working with Drs. Euan Ashley and MatthewWheeler on the MoTrPAC project. Young started on June 3rd.

Saira Purewal, Assistant Clinical Research Coordinator, is working with Drs Khush and Narayan on various heart transplant and electrophysiology clincial trials. Saira started June 10th.

Grants and Awards

Federal Grants and Subcontracts

Non-federal Grants and Contracts

Joshua Knowles – American Diabetes Association, Inc. Grant “Targeting inflammation and alloimmunity in heart transplant recipients with Tocilizumab”

January 1, 2019 – December 31, 2019

Koen Nieman – National Institutes of Health R01 “Comprehensive CT Guided Coronary Artery Bypass Graft Surgery” February 15, 2019 – January 31, 2024

Colleen Caleshu – Jane Engelberg Memorial Foundation Fellowship “nmA randomized controlled trial of meditation to improve genetic counselor and genetic counselingstudent professional well-being” January 1, 2019 – December 31, 2020

David Maron – Astra Zeneca Clinical Trial“A Multinational, Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Effect of Ticagrelor 90 mg twice daily on the Incidence of Cardiovascular Death, Myocardial Infarction or Stroke in Patients with Type 2 Diabetes Mellitus” [THEMIS - effect of Ticagrelor on Health outcomes in diabEtes Mellitus patients Intervention Study]May 16, 2019 – May 31, 2020

Congratulations to the 2019 graduating fellows!

Cassandra Hawthorne, Administrative Associate, is supporting the Heart Failure group. Cassandra started on June 24th.

New Sponsored Awards

Cardiology Fellowship Program

General Cardiology

Lee L. Chang, MD will be continuing at Stanford as a fellow in the Advanced Heart FailureTransplant Cardiology program.

Petra Mamic, MD will be continuing at Stanford as a research fellow with Dr. Michael Snyder inGenetics.

Alexander C. Perino, MD will be continuing at Stanford as a fellow in the Electrophysiology program.

Alexander Tarlochan Singh Sandhu, MD will be continuing at Stanford as a fellow in the Advanced Heart Failure Transplant Cardiology program.

Alberta Yen, MD will be going to Kaiser Permanente in Santa Clara to build their structural imaging and cardiac MRI programs.

Advanced Heart Failure Transplant Cardiology

Kevin Michael Alexander, MD will be continuing at Stanford as Instructor of Medicine(Cardiovascular Medicine).

Peter Czobor, MD will be going to Kaiser SF and Santa Clara to work part-time as a general and heart failure cardiologist while his wife, Karen Schultz finishes up the Adult Congenital Heart Diseasefellowship program.

Maxime Trembly-Gravel, MD will be continuing at Stanford as a research and clinical fellow in the echo/imaging fellowship program.

Adult Congenital Heart Disease

Melissa Morello, MD is headed to the University of Louisville as the Assistant Medical Director of the Adult Congenital Heart Disease Program as well as Assistant Professor of Pediatrics andMedicine (Pediatric Cardiology).

Echo / Imaging

Cindy Wang, MD will be a general cardiologist with the Advanced Cardiovascular Specialists group at El Camino Hospital. She will be specializing in multi-modality cardiac imaging and interventional echocardiography.

Electrophysiology

Jaskanwal (Sonny) Bisla, MD is headed to Phoenix, Arizona to a cardiovascular private practice.

Yan (Julie) Dong, MD is interviewing for academic positions.

Interventional Cardiology

Guson Kang, MD is headed to Henry Ford Health Care System in Detroit, Michigan to complete astructural interventions fellowship.

Yuhei Kobayashi, MD is interviewing for academic interventional positions.

Graduation Awards

Alan Yeung and Sharon Hunt Award for Outstanding Clinical Fellow: Jeffrey Lin

Reaven award for basic science: Paul Cheng

Alderman award for clinical research: Alex Sandhu and Lee Chang

Hancock teaching award: David Liang

Congratulations to David Ouyang for receiving a Stanford Artificial Intelligence in Medicine and Imaging (AIMI) Center Seed Grant on “Computer Vision Prediction of Cardiovascular Outcomes through Echo”.

Congratulations to Han Zhu for receiving a National Heart, Lung and Blood Institute F32 Ruth L. Kirschstein National Research Service Award on “Identification of Causal Antigens in Immune Checkpoint Inhibitor-Induced Myocarditis”.

Han was also selected to serve on the American Heart Association Cardio-Oncology Council as a FIT member!

Publications

Interventions to Reduce Ethnic and Racial Disparities in Dyslipidemia Management.Chang AY, Abou-Arraj NE, Rodriguez F. Curr Treat Options Cardiovasc Med. 2019 May 7;21(5):24. doi: 10.1007/s11936-019-0725-4.

Urinary tract infection after catheter ablation of atrial fibrillation.Cluckey A, Perino AC, Fan J, Askari M, Nasir J, Marcus GM, Baykaner T, Narayan SM, Wang PJ, Turakhia MP. Pacing Clin Electrophysiol. 2019 Jun 6. doi: 10.1111/pace.13738.

Site Variation and Outcomes for Antithrombotic Therapy in AF Patients after PCI: Findings from the Veterans Health Administration.Olivier CB, Fan J, Askari M, Mahaffey KW, Heidenreich PA, Perino AC, Leef GC, Ho PM, Harrington RA, Turakhia MP. Circulation: Cardiovascular Interventions. 2019. In Press.

Finding missed cases of familial hypercholesterolemia in health systems using machine learning.Juan M. Banda, Ashish Sarraju, Fahim Abbasi, Justin Parizo, Mitchel Pariani, Hannah Ison, ElinorBriskin, Hannah Wand, Sebastien Dubois, Kenneth Jung, Seth A. Myers, Daniel J. Rader, Joseph B. Leader, Michael F. Murray, Kelly D. Myers, Katherine Wilemon, Nigam H. Shah & Joshua W. Knowles. npj Digital Medicine 2019; 2: 23.

Presentations

Jeffrey Lin presented a moderated ePoster at the Heart Rhythm Society meeting in May on“Prevalence of Silent Atrial Fibrillation in the Women's Health Initiative Strong and Healthy Silent Atrial Fibrillation Recording Study (WHISH STAR)” Session: Epidemiology of AF Revisited

David Ouyang presented at the American Society of Echocardiography meeting as the Arthur Weyman Young Investigator Award Competition Finalist

Han Zhu presented at the Society of Cardiovascular Computed Tomography (SCCT) 2019 Annualmeeting on"Computational Fluid Dynamics of CABG Patients: CTA-derived Hemodynamic and Anatomic Predictors of Vein Graft Failure".

General CardiologyCaitlin Bell, MD – Stanford Aly Elezaby, MD, PhD – Stanford Maggie Ning, MD – StanfordPablo Sanchez, MD – Stanford Jimmy Tooley, MD – Stanford Chad Weldy, MD, PhD – Stanford

Advanced Heart Failure Transplant CardiologyHershey Avula, MD – KaiserLee Chang, MD – Stanford Alex Sandhu, MD – Stanford

Adult Congenital Heart DiseaseSumeet Vaikunth, MD – Stanford

Echo / ImagingMirela Tuzovic, MD – UCLA

ElectrophysiologyRidhima Kapoor, MD – Med College of Wisconsin Jeffrey Lin, MD – Stanford

Interventional CardiologyEric Chan, MD – Queen Mary Hospital Ryan Markham, MD – Prince Charles Hospital

Our Team in the News

Welcome the incoming Cardiology Fellows!

A Database of a Million VeteransDr. Phil Tsao are helping collect samples andmedical data from a million American veterans to create an enormous database of medical information.

Gene networks reveal transition from healthy to failing heartDr. Euan Ashley and team have mapped out anetwork of gene activity before and after heart failure to better understand how heart healthdeclines.

Even athletes may have high blood pressure, possiblyRecently promoted Assistant Clinical Professor, Dr. Kegan Moneghetti says even athletes canhave high blood pressure.

E-cigarette use, flavorings may increase heart disease risk, studyfindsDr. Joseph Wu and team study E-cigarette use,flavorings may increase heart disease risk.

Big data, from computer models to clinic, is focus of conferenceMultiple faculty from Cardiovascular Medicineattended and presented at the annual Big Data in Precision Health Conference including Drs. Euan Ashley, Marco Perez, and Mintu Turakhia.

Vascular Discovery: From Genes to MedicineCongratulations to Dr. Robert Wirka whorecently won the ATVB Irvine H. Page Young Investigator Research Award at the American Heart Association meeting.

CV Med Quarterly Socials –All socials begin at 4:30pm in the Falk Library (or outside patio when weather permits). 2019 Socials are on Thursdays. The next quarterly social will take place in September or October. Date and location: TBD.

Featured Cardiovascular Medicine Conferences

Cardiology Grand Rounds calendar

Weekly CGR’s are on Thursdays at 8am in the Falk Library.

Electrophysiology in the West 2019: The Latest Advances in Arrhythmia CareCourse Director: Paul Wang MDStanford UniversityLi Ka Shing Center for Learning and KnowledgeSeptember 13, 2019

Additional Cardiovascular Medicine CME information

Complete list of Stanford CME courses

Monthly:

Frontiers in Cardiovascular ScienceTuesdays from 12:30 – 1:20pmStanford University Li Ka Shing Center291 Campus Drive, Stanford, CA

Additional Conferences and Meetings

July 2019

Stanford University27th Annual Pediatric Update and Pre-Conference: What’s New in Allergy and Pulmonology

Register TODAY!Sunday, September 8, 2019

7:30am – 11:30am

Lab-grown heart cells reveal secrets of “kissing bug” diseaseDr. Joseph Wu’s lab-grown heart cells revealsecrets of “kissing bug” disease.

Upcoming Events and Conferences

2019 July 18-20, 2019 The Frances C. Arrillaga Alumni Center, Stanford, CA Pediatric Conference

American Heart AssociationBasic Cardiovascular Sciences Scientific SessionsJuly 29–August 1, 2019 Westin Boston Waterfront | Boston, MA AHA

August 2019

Cardiology Update: The Heart of the Matter 2019August 1, 2019 to August 4, 2019Sedona, AZMayo Clinic

American College of CardiologyACC/SCAI Premier Interventional Cardiology Overview and Board Preparatory CourseAugust 8, 2019 - August 11, 2019ACC

September 2019

American Heart AssociationHypertension 2019 Scientific SessionsSeptember 5–8, 2019New Orleans Marriott | New Orleans, LouisianaAHA

American College of Cardiology2019 Cardiovascular Service Lines 101 WebinarSeptember 12, 2019 12:00 PM - 1:00 PMACC

October 2019

American College of CardiologyCore Curriculum for the Cardiovascular ClinicianOctober 2- 5, 2019Washington, DCACC

American College of CardiologyHeart Valve Summit: Medical, Surgical and Interventional Decision MakingOctober 3- 5, 2019Chicago, ILACC

If you are thinking about applying to a grant, email Crystal or Pete to learn more about the Division of Cardiovascular Medicine’s research development and proposal writing resources.

AHA grants

Additional Funding:Cardiovascular Disease Funding Opportunities, Internal Funding Opportunities, Postdocs andClinical Fellows, Graduate Student

RMG Funding Information Resource webpage

NIH, AHRQ and NIOSH K Career Development Award Funding Opportunities and ComputerLab Training Sessions:RMG Index of NIH K award program announcements and other resources

Continuous Submissions

Intermountain-Stanford Collaboration GrantRequest for Letters of Intent for Travel GrantsLetters of intent may be submitted at any time. Applicants will be notified within 21 days ofsubmission.Award Amount: Reimburse actual costsIntermountain-Stanford

Cardiovascular Medicine Training Grants

Cardiovascular Imaging Postdoctoral Fellowship Training at StanfordCV Imaging

Training in Myocardial Biology at Stanford (TIMBS)TIMBS

Mechanisms and Innovations in Cardiovascular Disease T32 Training GrantT32

July 2019

Dr. Jeffrey Thomas Stroke Shield FoundationBlood Pressure Management Program: Community-research partnerships to reduce strokerate and hypertension in underserved communities in Alameda County, CA New $210,000funding opportunity from a local foundation for Stanford faculty with PI eligibility and CEfacultyLetter of intent (required) deadline: JulyFull proposal (by invitation only) deadline: Sept.GuidelinesLOI instructions

Upcoming Funding Opportunities

Included in this newsletter are cardiovascular medicine faculty publications for the months of January – April. Publications are in date order from newest to oldest.

JULY

Trends in overall, cardiovascular and cancer-related mortality among individuals with diabetes reported on death certificates in the United States between 2007 and 2017.Kim D, Li AA, Cholankeril G, Kim SH, Ingelsson E, Knowles JW, Harrington RA, Ahmed A. Diabetologia. 2019 Jul;62(7):1185-1194. doi: 10.1007/s00125-019-4870-9.

Surveillance of Congenital Heart Defects among Adolescents at Three U.S. Sites.Lui GK, McGarry C, Bhatt A, Book W, Riehle-Colarusso TJ, Dunn JE, Glidewell J, Gurvitz M, Hoffman T, Hogue CJ, Hsu D, Obenhaus S, Raskind-Hood C, Rodriguez FH 3rd, Zaidi A, Van Zutphen AR. Am J Cardiol. 2019 Jul 1;124(1):137-143. doi: 10.1016/j.amjcard.2019.03.044.

Propagation velocity at atrial fibrillation sources: Go with the flow.Rogers AJ, Bhatia NK, Brodt CR, Narayan SM. Int J Cardiol. 2019 Jul 1;286:76-77. doi: 10.1016/j.ijcard.2019.04.007.

Generation of Endothelial Cells From Human Pluripotent Stem Cells.Williams IM, Wu JC. Arterioscler Thromb Vasc Biol. 2019 Jul;39(7):1317-1329. doi: 10.1161/ATVBAHA.119.312265.

JUNE

The efficacy and safety of cangrelor in single vessel vs multi vessel percutaneous coronary intervention: Insights from CHAMPION PHOENIX.Yong CM, Sundaram V, Abnousi F, Olivier CB, Yang J, Stone GW, Steg PG, Michael Gibson C, Hamm CW, Price MJ, Deliargyris EN, Prats J, White HD, Harrington RA, Bhatt DL, Mahaffey KW; CHAMPION PHOENIX Investigators. Clin Cardiol. 2019 Jun 29. doi: 10.1002/clc.23221.

Identification of rare-disease genes using blood transcriptome sequencing and large control cohorts.Frésard L, Smail C, Ferraro NM, Teran NA, Li X, Smith KS, Bonner D, Kernohan KD, Marwaha S, Zappala Z, Balliu B, Davis JR, Liu B, Prybol CJ, Kohler JN, Zastrow DB, Reuter CM, Fisk DG, Grove ME, Davidson JM, Hartley T, Joshi R, Strober BJ, Utiramerur S; Undiagnosed Diseases Network; Care4Rare Canada Consortium, Lind L, Ingelsson E, Battle A, Bejerano G, Bernstein JA, Ashley EA, Boycott KM, Merker JD, Wheeler MT, Montgomery SB. Nat Med. 2019 Jun;25(6):911-919. doi: 10.1038/s41591-019-0457-8.

Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure overload heart failure.Cordero P, Parikh VN, Chin ET, Erbilgin A, Gloudemans MJ, Shang C, Huang Y, Chang AC, Smith KS, Dewey F, Zaleta K, Morley M, Brandimarto J, Glazer N, Waggott D, Pavlovic A, Zhao M, Moravec CS, Tang WHW, Skreen J, Malloy C, Hannenhalli S, Li H, Ritter S, Li M, Bernstein D, Connolly A, Hakonarson H, Lusis AJ, Margulies KB, Depaoli-Roach AA, Montgomery SB, Wheeler MT, Cappola T, Ashley EA. Nat Commun. 2019 Jun 24;10(1):2760. doi: 10.1038/s41467-019-10591-5.

Publications

Modelling diastolic dysfunction in induced pluripotent stem cell-derived cardiomyocytes from hypertrophic cardiomyopathy patients.Wu H, Yang H, Rhee JW, Zhang JZ, Lam CK, Sallam K, Chang ACY, Ma N, Lee J, Zhang H, Blau HM, Bers DM, Wu JC. Eur Heart J. 2019 Jun 20. pii: ehz326. doi: 10.1093/eurheartj/ehz326.

A Combination of Itraconazole and Amiodarone Is Highly Effective against Trypanosoma cruziInfection of Human Stem Cell-Derived Cardiomyocytes.Sass G, Madigan RT, Joubert LM, Bozzi A, Sayed N, Wu JC, Stevens DA. Am J Trop Med Hyg. 2019 Jun 17. doi: 10.4269/ajtmh.19-0023.

Psychological Distress Among Female Cardiac Patients Presenting to a Women's Heart Health Clinic.Edwards KS, Hekler AC, Baum J, Nejedly M, Tsai S, Khandelwal A, Naderi S, Hoover V, Tremmel JA. Am J Cardiol. 2019 Jun 15;123(12):2026-2030. doi: 10.1016/j.amjcard.2019.03.029.

Incidence and Cost of Major Adverse Cardiovascular Events and Major Adverse Limb Events in Patients With Chronic Coronary Artery Disease or Peripheral Artery Disease.Berger A, Simpson A, Bhagnani T, Leeper NJ, Murphy B, Nordstrom B, Ting W, Zhao Q, Berger JS. Am J Cardiol. 2019 Jun 15;123(12):1893-1899. doi: 10.1016/j.amjcard.2019.03.022.

Defining genotype-phenotype relationships in patients with hypertrophic cardiomyopathy using cardiovascular magnetic resonance imaging.Miller RJH, Heidary S, Pavlovic A, Schlachter A, Dash R, Fleischmann D, Ashley EA, Wheeler MT, Yang PC. PLoS One. 2019 Jun 14;14(6):e0217612. doi: 10.1371/journal.pone.0217612.

Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy.Perkovic V, Jardine MJ, Neal B, Bompoint S, Heerspink HJL, Charytan DM, Edwards R, Agarwal R, Bakris G, Bull S, Cannon CP, Capuano G, Chu PL, de Zeeuw D, Greene T, Levin A, Pollock C, Wheeler DC, Yavin Y, Zhang H, Zinman B, Meininger G, Brenner BM, Mahaffey KW; CREDENCE Trial Investigators. N Engl J Med. 2019 Jun 13;380(24):2295-2306. doi: 10.1056/NEJMoa1811744.

EXPRESS: Myocardial Bridge - An Unrecognized Cause of Chest Pain in Pulmonary Arterial Hypertension.Rajmohan D, Sung YK, Kudelko K, Perez VAJ, Haddad F, Tremmel J, Schnittger I, Zamanian RT, Spiekerkoetter EF. Pulm Circ. 2019 Jun 12:2045894019860738. doi: 10.1177/2045894019860738.

Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes as a Model to Study Trypanosoma cruzi Infection.Bozzi A, Sayed N, Matsa E, Sass G, Neofytou E, Clemons KV, Correa-Oliveira R, Stevens DA, Wu JC. Stem Cell Reports. 2019 Jun 11;12(6):1232-1241. doi: 10.1016/j.stemcr.2019.04.017.

Blood Pressure and Incident Atrial Fibrillation in Older Patients Initiating Hemodialysis.Chang TI, Liu S, Airy M, Niu J, Turakhia MP, Flythe JE, Montez-Rath ME, Winkelmayer WC. Clin J Am Soc Nephrol. 2019 Jun 7. pii: CJN.13511118. doi: 10.2215/CJN.13511118.

OJ, Ding D, Heilshorn SC, Li K. ACS Nano. 2019 Jun 7. doi: 10.1021/acsnano.9b03343.

Urinary tract infection after catheter ablation of atrial fibrillation.Cluckey A, Perino AC, Fan J, Askari M, Nasir J, Marcus GM, Baykaner T, Narayan SM, Wang PJ, Turakhia MP. Pacing Clin Electrophysiol. 2019 Jun 6. doi: 10.1111/pace.13738.

Modeling Cardiovascular Risks of E-Cigarettes With Human-Induced Pluripotent Stem Cell-Derived Endothelial Cells.Lee WH, Ong SG, Zhou Y, Tian L, Bae HR, Baker N, Whitlatch A, Mohammadi L, Guo H, Nadeau KC, Springer ML, Schick SF, Bhatnagar A, Wu JC. J Am Coll Cardiol. 2019 Jun 4;73(21):2722-2737. doi: 10.1016/j.jacc.2019.03.476.

Less Risky Immunosuppression in Heart Transplantation?Hunt SA. J Am Coll Cardiol. 2019 Jun 4;73(21):2689-2690. doi: 10.1016/j.jacc.2019.03.472.

Clonal Smooth Muscle Cell Expansion, Autophagy, and Vascular Integrity in Aortic Aneurysm Disease.Wang Y, Nanda V, Leeper NJ. Arterioscler Thromb Vasc Biol. 2019 Jun;39(6):982-983. doi: 10.1161/ATVBAHA.119.312739.

Stroke in Patients With Peripheral Artery Disease.Kolls BJ, Sapp S, Rockhold FW, Jordan JD, Dombrowski KE, Fowkes FGR, Mahaffey KW, Berger JS, Katona BG, Blomster JI, Norgren L, Abramson BL, Leiva-Pons JL, Prieto JC, Sokurenko G, Hiatt WR, Jones WS, Patel MR. Stroke. 2019 Jun;50(6):1356-1363. doi: 10.1161/STROKEAHA.118.023534.

Cardiometabolic Proteins Associated with Metabolic Syndrome.Lind L, Elmståhl S, Ingelsson E. Metab Syndr Relat Disord. 2019 Jun;17(5):272-279. doi: 10.1089/met.2018.0123.

A Patient with Sjogren's Syndrome and Subsequent Diagnosis of Inclusion Body Myositis and Light-Chain Amyloidosis.Hom J, Marwaha S, Postolova A, Kittle J, Vasquez R, Davidson J, Kohler J, Dries A, Fernandez-Betancourt L, Majcherska M, Dearlove J, Raghavan S, Vogel H, Bernstein JA, Fisher P, Ashley E, Sampson J, Wheeler M; Undiagnosed Diseases Network. J Gen Intern Med. 2019 Jun;34(6):1058-1062. doi: 10.1007/s11606-019-04931-w.

Extracutaneous manifestations in phacomatosis cesioflammea and cesiomarmorata: Case series and literature review.Kumar A, Zastrow DB, Kravets EJ, Beleford D, Ruzhnikov MRZ, Grove ME, Dries AM, Kohler JN, Waggott DM, Yang Y, Huang Y; Undiagnosed Diseases Network, Mackenzie KM, Eng CM, FisherPG, Ashley EA, Teng JM, Stevenson DA, Shieh JT, Wheeler MT, Bernstein JA. Am J Med Genet A. 2019 Jun;179(6):966-977. doi: 10.1002/ajmg.a.61134

Comparison of QT Interval Measurement Methods and Correction Formulas in Atrial Fibrillation.Tooley J, Ouyang D, Hadley D, Turakhia M, Wang P, Ashley E, Froelicher V, Perez M. Am J Cardiol. 2019 Jun 1;123(11):1822-1827. doi: 10.1016/j.amjcard.2019.02.057.

Effects of canagliflozin on amputation risk in type 2 diabetes: the CANVAS Program.Matthews DR, Li Q, Perkovic V, Mahaffey KW, de Zeeuw D, Fulcher G, Desai M, Hiatt WR, NehlerM, Fabbrini E, Kavalam M, Lee M, Neal B.

An in Vivo miRNA Delivery System for Restoring Infarcted Myocardium.Yang H, Qin X, Wang H, Zhao X, Liu Y, Wo HT, Liu C, Nishiga M, Chen H, Ge J, Sayed N, Abilez

Diabetologia. 2019 Jun;62(6):926-938. doi: 10.1007/s00125-019-4839-8.

Rapid Genome Sequencing in the Critically Ill.Buchan JG, White S, Joshi R, Ashley EA. Clin Chem. 2019 Jun;65(6):723-726. doi: 10.1373/clinchem.2018.293506.

The role of epigenetic aging in education and racial/ethnic mortality disparities among older U.S. Women.Liu Z, Chen BH, Assimes TL, Ferrucci L, Horvath S, Levine ME. Psychoneuroendocrinology. 2019 Jun;104:18-24. doi: 10.1016/j.psyneuen.2019.01.028.

Accuracy of Administrative Coding to Identify Reduced and Preserved Left Ventricular Ejection Fraction.Heidenreich PA, Natarajan S, Bahrami H. J Card Fail. 2019 Jun;25(6):486-489. doi: 10.1016/j.cardfail.2019.01.019.

Infectious complications after heart transplantation in patients screened with gene expression profiling.Moayedi Y, Gomez CA, Fan CPS, Miller RJH, Bunce PE, Tremblay-Gravel M, Foroutan F, Manlhiot C, Yee J, Shullo MA, Khush KK, Ross HJ, Montoya JG, Teuteberg JJ. J Heart Lung Transplant. 2019 Jun;38(6):611-618. doi: 10.1016/j.healun.2019.01.006.

Comparison between instantaneous wave-free ratio versus morphometric assessments by intracoronary imaging.Matsushita K, Hibi K, Okada K, Sakamaki K, Akiyama E, Kimura Y, Matsuzawa Y, Maejima N, Iwahashi N, Tsukahara K, Kosuge M, Ebina T, Fitzgerald PJ, Honda Y, Tamura K, Kimura K. Heart Vessels. 2019 Jun;34(6):926-935. doi: 10.1007/s00380-018-1320-4.

Cancer therapy-induced cardiomyopathy: can human induced pluripotent stem cell modelling help prevent it?Stack JP, Moslehi J, Sayed N, Wu JC. Eur Heart J. 2019 Jun 7;40(22):1764-1770. doi: 10.1093/eurheartj/ehx811.

MAY

The metabolites urobilin and sphingomyelin (30:1) are associated with incident heart failure in the general population.Stenemo M, Ganna A, Salihovic S, Nowak C, Sundström J, Giedraitis V, Broeckling CD, Prenni JE, Svensson P, Magnusson PKE, Lind L, Ingelsson E, Ärnlöv J, Fall T. ESC Heart Fail. 2019 May 30. doi: 10.1002/ehf2.12453.

Athletic Remodeling in Female College Athletes: The "Morganroth Hypothesis" Revisited.Kooreman Z, Giraldeau G, Finocchiaro G, Kobayashi Y, Wheeler M, Perez M, Moneghetti K,Oxborough D, George KP, Myers J, Ashley E, Haddad F.Clin J Sport Med. 2019 May;29(3):224-231. doi: 10.1097/JSM.0000000000000501.

Single cell expression analysis reveals anatomical and cell cycle-dependent transcriptional shifts during heart development.Li G, Tian L, Goodyer W, Kort EJ, Buikema JW, Xu A, Wu J, Jovinge S, Wu SM. Development. 2019 May 29. pii: dev.173476. doi: 10.1242/dev.173476.

Blood pressure in athletic preparticipation evaluation and the implication for cardiac remodelling.Hedman K, Moneghetti KJ, Christle JW, Bagherzadeh SP, Amsallem M, Ashley E, Froelicher V, Haddad F.Heart. 2019 May 28. pii: heartjnl-2019-314815. doi: 10.1136/heartjnl-2019-314815.

Effects of Canagliflozin on Heart Failure Outcomes Associated With Preserved and Reduced Ejection Fraction in Type 2 Diabetes Mellitus.Figtree GA, Rådholm K, Barrett TD, Perkovic V, Mahaffey KW, de Zeeuw D, Fulcher G, Matthews DR, Shaw W, Neal B. Circulation. 2019 May 28;139(22):2591-2593. doi: 10.1161/CIRCULATIONAHA.119.040057.

Practice Variation in Anticoagulation Prescription and Outcomes After Device-Detected Atrial Fibrillation.Perino AC, Fan J, Askari M, Heidenreich PA, Keung E, Raitt MH, Piccini JP, Ziegler PD, Turakhia MP.Circulation. 2019 May 28;139(22):2502-2512. doi: 10.1161/CIRCULATIONAHA.118.038988.

The prognostic importance of silent ischemia.Fearon WF.Int J Cardiol. 2019 May 24. pii: S0167-5273(18)35333-6. doi: 10.1016/j.ijcard.2019.05.050.

Adrenomedullin and endothelin-1: Promising biomarkers of endothelial function, but not ready for prime time.Parikh RV, Fearon WF.Int J Cardiol. 2019 May 23. pii: S0167-5273(19)31843-1. doi: 10.1016/j.ijcard.2019.05.049.

Effects of alirocumab on types of myocardial infarction: insights from the ODYSSEY OUTCOMES trial.White HD, Steg PG, Szarek M, Bhatt DL, Bittner VA, Diaz R, Edelberg JM, Erglis A, Goodman SG, Hanotin C, Harrington RA, Jukema JW, Lopes RD, Mahaffey KW, Moryusef A, Pordy R, Roe MT, Sritara P, Tricoci P, Zeiher AM, Schwartz GG. Eur Heart J. 2019 May 23. pii: ehz299. doi: 10.1093/eurheartj/ehz299.

Effect of Alirocumab on Mortality After Acute Coronary Syndromes: An Analysis of the ODYSSEY OUTCOMES Randomized Clinical Trial.Steg PG, Szarek M, Bhatt DL, Bittner VA, Brégeault MF, Dalby AJ, Diaz R, Edelberg JM, Goodman SG, Hanotin C, Harrington RA, Jukema JW, Lecorps G, Mahaffey KW, Moryusef A, Ostadal P, Parkhomenko A, Pordy R, Roe MT, Tricoci P, Vogel R, White HD, Zeiher AM, Schwartz GG; ODYSSEY OUTCOMES Committees and Investigators. Circulation. 2019 May 23. doi: 10.1161/CIRCULATIONAHA.118.038840.

The Comparative Effect of Roux-en-Y Gastric Bypass and Sleeve Gastrectomy on 10-Year and Lifetime Atherosclerotic Cardiovascular Disease Risk.Raygor V, Garcia L, Maron DJ, Morton JM. Obes Surg. 2019 May 21. doi: 10.1007/s11695-019-03948-8.

Human-Induced Pluripotent Stem Cell Model of Trastuzumab-Induced Cardiac Dysfunction in Patients With Breast Cancer.Kitani T, Ong SG, Lam CK, Rhee JW, Zhang JZ, Oikonomopoulos A, Ma N, Tian L, Lee J, Telli ML, Witteles RM, Sharma A, Sayed N, Wu JC.Circulation. 2019 May 21;139(21):2451-2465. doi: 10.1161/CIRCULATIONAHA.118.037357.

Improving risk stratification in heart failure with preserved ejection fraction by combining two validated risk scores.Boralkar KA, Kobayashi Y, Moneghetti KJ, Pargaonkar VS, Tuzovic M, Krishnan G, Wheeler MT, Banerjee D, Kuznetsova T, Horne BD, Knowlton KU, Heidenreich PA, Haddad F.Open Heart. 2019 May 21;6(1):e000961. doi: 10.1136/openhrt-2018-000961.

RRAD mutation causes electrical and cytoskeletal defects in cardiomyocytes derived from a familial case of Brugada syndrome.Belbachir N, Portero V, Al Sayed ZR, Gourraud JB, Dilasser F, Jesel L, Guo H, Wu H, Gaborit N, Guilluy C, Girardeau A, Bonnaud S, Simonet F, Karakachoff M, Pattier S, Scott C, Burel S,Marionneau C, Chariau C, Gaignerie A, David L, Genin E, Deleuze JF, Dina C, Sauzeau V, Loirand G, Baró I, Schott JJ, Probst V, Wu JC, Redon R, Charpentier F, Le Scouarnec S. Eur Heart J. 2019 May 21. pii: ehz308. doi: 10.1093/eurheartj/ehz308.

Prehospital Phase of Acute Stroke Care: Guideline and Policy Considerations as Science and Evidence Rapidly Evolve.Harrington RA.Stroke. 2019 May 20:STROKEAHA119025584. doi: 10.1161/STROKEAHA.119.025584.

Proteasome-Dependent Regulation of Distinct Metabolic States During Long-Term Culture of Human iPSC-Derived Cardiomyocytes.Ebert A, Joshi AU, Andorf S, Dai Y, Sampathkumar S, Chen H, Li Y, Garg P, Toischer K, Hasenfu G, Mochly Rosen D, Wu JC.Circ Res. 2019 May 20. doi: 10.1161/CIRCRESAHA.118.313973.

Optimal balloon positioning for the proximal optimization technique? An experimental bench study.Dérimay F, Rioufol G, Nishi T, Kobayashi Y, Fearon WF, Veziers J, Guérin P, Finet G. Int J Cardiol. 2019 May 18. pii: S0167-5273(19)32031-5. doi: 10.1016/j.ijcard.2019.05.041.

Therapeutic perspective on vascular cognitive impairment.Toyama K, Spin JM, Mogi M, Tsao PS.Pharmacol Res. 2019 May 17;146:104266. doi: 10.1016/j.phrs.2019.104266.

Author Correction: Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.Kranzler HR, Zhou H, Kember RL, Smith RV, Justice AC, Damrauer S, Tsao PS, Klarin D, Baras A, Reid J, Overton J, Rader DJ, Cheng Z, Tate JP, Becker WC, Concato J, Xu K, Polimanti R, Zhao H, Gelernter J. Nat Commun. 2019 May 17;10(1):2275. doi: 10.1038/s41467-019-10254-5.

Blood Pressure Control and Cardiovascular Outcomes in Patients With Atrial Fibrillation (From the ORBIT-AF Registry).Vemulapalli S, Inohara T, Kim S, Thomas L, Piccini JP, Patel MR, Chang P, Fonarow GC, Ezekowitz MD, Hylek E, Go AS, Kowey PR, Mahaffey KW, Gersh BJ, Peterson ED. Am J Cardiol. 2019 May 15;123(10):1628-1636. doi: 10.1016/j.amjcard.2019.02.010.

Targeted Long-Read RNA Sequencing Demonstrates Transcriptional Diversity Driven by Splice-Site Variation in MYBPC3.Dainis A, Tseng E, Clark TA, Hon T, Wheeler M, Ashley E.Circ Genom Precis Med. 2019 May;12(5):e002464. doi: 10.1161/CIRCGEN.119.002464.

Identifying the Transcriptome Signatures of Calcium Channel Blockers in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.Lam CK, Tian L, Belbachir N, Shrestha R, Ma N, Kitani T, Rhee JW, Wnorowski A, Wu JC.Circ Res. 2019 May 13. doi: 10.1161/CIRCRESAHA.118.314202.

Toyama K, Spin JM, Abe Y, Suzuki Y, Deng AC, Wagenhäuser MU, Yoshino T, Mulorz J, Liu S, Tsao PS, Mogi M. J Pharmacol Sci. 2019 May 11. pii: S1347-8613(19)31046-1. doi: 10.1016/j.jphs.2019.03.007.

Stanford Cardiovascular Institute.Wu JC, Woo YJ, Mayerle M, Harrington RA, Quertermous T.Circ Res. 2019 May 10;124(10):1420-1424. doi: 10.1161/CIRCRESAHA.119.310761.

The West coast regional safety pharmacology society meeting update: Filling translational gaps in safety assessment.Abi-Gerges N, McMahon C, Vargas H, Sager P, Chui R, Stevens D, Davila J, Schaub JR, Wu JC, Del Rio C, Mathes C, Miller PE, Burns-Naas LA, Ghetti A. J Pharmacol Toxicol Methods. 2019 May 9;98:106582. doi: 10.1016/j.vascn.2019.106582.

Treatment of volumetric muscle loss in mice using nanofibrillar scaffolds enhances vascular organization and integration.Nakayama KH, Quarta M, Paine P, Alcazar C, Karakikes I, Garcia V, Abilez OJ, Calvo NS, Simmons CS, Rando TA, Huang NF. Commun Biol. 2019 May 7;2:170. doi: 10.1038/s42003-019-0416-4.

Interventions to Reduce Ethnic and Racial Disparities in Dyslipidemia Management.Chang AY, Abou-Arraj NE, Rodriguez F.Curr Treat Options Cardiovasc Med. 2019 May 7;21(5):24. doi: 10.1007/s11936-019-0725-4.

Maternal Comorbidities and Complications of Delivery in Pregnant Women With Congenital Heart Disease.Schlichting LE, Insaf TZ, Zaidi AN, Lui GK, Van Zutphen AR. J Am Coll Cardiol. 2019 May 7;73(17):2181-2191. doi: 10.1016/j.jacc.2019.01.069.

Comparison of Patient-Reported Care Satisfaction, Quality of Warfarin Therapy, and Outcomes of Atrial Fibrillation: Findings From the ORBIT - AF Registry.Perino AC, Shrader P, Turakhia MP, Ansell JE, Gersh BJ, Fonarow GC, Go AS, Kaiser DW, Hylek EM, Kowey PR, Singer DE, Thomas L, Steinberg BA, Peterson ED, Piccini JP, Mahaffey KW.J Am Heart Assoc. 2019 May 7;8(9):e011205. doi: 10.1161/JAHA.118.011205.

A paradoxical relationship between hemoglobin A1C and in-hospital mortality in intracerebral hemorrhage patients.Dandapat S, Siddiqui FM, Fonarow GC, Bhatt DL, Xu H, Matsouaka R, Heidenreich PA, Xian Y, Schwamm LH, Smith EE. Heliyon. 2019 May 6;5(5):e01659. doi: 10.1016/j.heliyon.2019.e01659.

Semiautomated Characterization of Carotid Artery Plaque Features From Computed Tomography Angiography to Predict Atherosclerotic Cardiovascular Disease Risk Score.Zhu G, Li Y, Ding V, Jiang B, Ball RL, Rodriguez F, Fleischmann D, Desai M, Saloner D, Gupta A, Saba L, Hom J, Wintermark M. J Comput Assist Tomogr. 2019 May 6. doi: 10.1097/RCT.0000000000000862.

Editorial: High density mapping of atrial fibrillation sources.Rogers AJ, Bhatia NK, Brodt C, Narayan SM.J Cardiovasc Electrophysiol. 2019 May 6. doi: 10.1111/jce.13949.

TCF21 and AP-1 interact through epigenetic modifications to regulate coronary artery disease geneexpression.Zhao Q, Wirka R, Nguyen T, Nagao M, Cheng P, Miller CL, Kim JB, Pjanic M, Quertermous T.

Controlled isoflurane anesthesia exposure is required for reliable behavioral testing in murine surgical models.

Genome Med. 2019 May 2;11(1):23. doi: 10.1186/s13073-019-0635-9.

A Human iPSC Double-Reporter System Enables Purification of Cardiac Lineage Subpopulations with Distinct Function and Drug Response Profiles.Zhang JZ, Termglinchan V, Shao NY, Itzhaki I, Liu C, Ma N, Tian L, Wang VY, Chang ACY, Guo H, Kitani T, Wu H, Lam CK, Kodo K, Sayed N, Blau HM, Wu JC.Cell Stem Cell. 2019 May 2;24(5):802-811.e5. doi: 10.1016/j.stem.2019.02.015.

A longitudinal big data approach for precision health.Schüssler-Fiorenza Rose SM, Contrepois K, Moneghetti KJ, Zhou W, Mishra T, Mataraso S, Dagan-Rosenfeld O, Ganz AB, Dunn J, Hornburg D, Rego S, Perelman D, Ahadi S, Sailani MR, Zhou Y, Leopold SR, Chen J, Ashland M, Christle JW, Avina M, Limcaoco P, Ruiz C, Tan M, Butte AJ, Weinstock GM, Slavich GM, Sodergren E, McLaughlin TL, Haddad F, Snyder MP. Nat Med. 2019 May;25(5):792-804. doi: 10.1038/s41591-019-0414-6.

Abundant associations with gene expression complicate GWAS follow-up.Liu B, Gloudemans MJ, Rao AS, Ingelsson E, Montgomery SB. Nat Genet. 2019 May;51(5):768-769. doi: 10.1038/s41588-019-0404-0.

Comparison of Rates of Bleeding and Vascular Complications Before, During, and After Trial Enrollment in the SAFE-PCI Trial for Women.Rymer JA, Kaltenbach LA, Kochar A, Hess CN, Gilchrist IC, Messenger JC, Harrington RA, Jolly SS, Jacobs AK, Abbott JD, Wojdyla DM, Krucoff MW, Rao SV. Circ Cardiovasc Interv. 2019 May;12(5):e007086. doi: 10.1161/CIRCINTERVENTIONS.118.007086.

An orange calcium-modulated bioluminescent indicator for non-invasive activity imaging.Oh Y, Park Y, Cho JH, Wu H, Paulk NK, Liu LX, Kim N, Kay MA, Wu JC, Lin MZ. Nat Chem Biol. 2019 May;15(5):433-436. doi: 10.1038/s41589-019-0256-z.

Clinical outcomes after direct and indirect surgical venous thrombectomy for inferior vena cava thrombosis.Wagenhäuser MU, Dimopoulos C, Antakyali K, Meyer-Janiszewski YK, Mulorz J, Ibing W, Ertas N, Spin JM, Schelzig H, Duran M.J Vasc Surg Venous Lymphat Disord. 2019 May;7(3):333-343.e2. doi: 10.1016/j.jvsv.2018.11.005.

Identification of 22 novel loci associated with urinary biomarkers of albumin, sodium, and potassium excretion.Zanetti D, Rao A, Gustafsson S, Assimes TL, Montgomery SB, Ingelsson E.Kidney Int. 2019 May;95(5):1197-1208. doi: 10.1016/j.kint.2018.12.017.

No evidence of a causal association of type 2 diabetes and glucose metabolism with atrial fibrillation.

Harati H, Zanetti D, Rao A, Gustafsson S, Perez M, Ingelsson E, Knowles JW.Diabetologia. 2019 May;62(5):800-804. doi: 10.1007/s00125-019-4836-y.

Rationale, design and baseline characteristics of the effect of ticagrelor on health outcomes in diabetes mellitus patients Intervention study.Bhatt DL, Fox K, Harrington RA, Leiter LA, Mehta SR, Simon T, Andersson M, Himmelmann A,Ridderstråle W, Held C, Steg PG; THEMIS Steering Committee. Clin Cardiol. 2019 May;42(5):498-505. doi: 10.1002/clc.23164.

Smooth Muscle Cells Contribute the Majority of Foam Cells in ApoE (Apolipoprotein E)-Deficient Mouse Atherosclerosis.Wang Y, Dubland JA, Allahverdian S, Asonye E, Sahin B, Jaw JE, Sin DD, Seidman MA, Leeper NJ, Francis GA. Arterioscler Thromb Vasc Biol. 2019 May;39(5):876-887. doi: 10.1161/ATVBAHA.119.312434.

Association of frailty and cognitive impairment with benefits of oral anticoagulation in patients with atrial fibrillation.Madhavan M, Holmes DN, Piccini JP, Ansell JE, Fonarow GC, Hylek EM, Kowey PR, Mahaffey KW, Thomas L, Peterson ED, Chan P, Allen LA, Gersh BJ; ORBIT AF Investigators.Am Heart J. 2019 May;211:77-89. doi: 10.1016/j.ahj.2019.01.005.

Extended cardiac ambulatory rhythm monitoring in adults with congenital heart disease: Arrhythmia detection and impact of extended monitoring.Schultz KE, Lui GK, McElhinney DB, Long J, Balasubramanian V, Sakarovitch C, Fernandes SM, Dubin AM, Rogers IS, Romfh AW, Motonaga KS, Viswanathan MN, Ceresnak SR. Congenit Heart Dis. 2019 May;14(3):410-418. doi: 10.1111/chd.12736.

Echocardiographic Evaluation of Patients Undergoing Transcatheter Tricuspid Valve-In-Valve Replacement.Tompkins R, Kelle AM, Cabalka AK, Lui GK, Aboulhosn J, Dvir D, McElhinney DB; VIVID Registry. J Am Soc Echocardiogr. 2019 May;32(5):616-623. doi: 10.1016/j.echo.2018.12.008.

CANDI: an R package and Shiny app for annotating radiographs and evaluating computer-aided diagnosis.Badgeley MA, Liu M, Glicksberg BS, Shervey M, Zech J, Shameer K, Lehar J, Oermann EK, McConnell MV, Snyder TM, Dudley JT.Bioinformatics. 2019 May 1;35(9):1610-1612. doi: 10.1093/bioinformatics/bty855.

Accuracy of non-invasive stress testing in women and men with angina in the absence of obstructive coronary artery disease.Pargaonkar VS, Kobayashi Y, Kimura T, Schnittger I, Chow EKH, Froelicher VF, Rogers IS, Lee DP, Fearon WF, Yeung AC, Stefanick ML, Tremmel JA.Int J Cardiol. 2019 May 1;282:7-15. doi: 10.1016/j.ijcard.2018.10.073.

A novel pacing maneuver to verify the postpacing interval minus the tachycardia cycle length while adjusting for decremental conduction: Using "dual-chamber entrainment" for improved supraventricular tachycardia discrimination.Kaiser DW, Nasir JM, Liem LB, Brodt C, Motonaga KS, Ceresnak SR, Turakhia MP, Dubin AM. Heart Rhythm. 2019 May;16(5):717-723. doi: 10.1016/j.hrthm.2018.11.021.

Index of Microcirculatory Resistance and Infarct Size.Fearon WF, Dash R.JACC Cardiovasc Imaging. 2019 May;12(5):849-851. doi: 10.1016/j.jcmg.2018.04.004.

APRIL

Effect of Tube Voltage on Diagnostic Performance of Fractional Flow Reserve Derived From Coronary CT Angiography With Machine Learning: Results From the MACHINE Registry.De Geer J, Coenen A, Kim YH, Kruk M, Tesche C, Schoepf UJ, Kepka C, Yang DH, Nieman K, Persson A. AJR Am J Roentgenol. 2019 Apr 30:1-7. doi: 10.2214/AJR.18.20774.

Lifestyle, Glycosylated Hemoglobin A1c, and Survival Among Patients With Stable Ischemic Heart Disease and Diabetes.Mancini GBJ, Maron DJ, Hartigan PM, Spertus JA, Kostuk WJ, Berman DS, Teo KK, Weintraub WS, Boden WE; COURAGE Trial Research Group. J Am Coll Cardiol. 2019 Apr 30;73(16):2049-2058. doi: 10.1016/j.jacc.2018.11.067.

Cardiac function response to stenting in atherosclerotic renal artery disease with and without heart failure: results from the Carmel study.Kawarada O, Kume T, Zen K, Nakamura S, Hozawa K, Akimitsu T, Asano H, Ando H, Yamamoto Y,Yamashita T, Shinozaki N, Odashiro K, Sato T, Yuba K, Sakanoue Y, Uzu T, Okada K, Fitzgerald PJ, Honda Y, Yasuda S. ESC Heart Fail. 2019 Apr;6(2):319-327. doi: 10.1002/ehf2.12391.

A protocol update of the Fractional Flow Reserve versus Angiography for Multivessel Evaluation (FAME) 3 trial: A comparison of fractional flow reserve-guided percutaneous coronary intervention and coronary artery bypass graft surgery in patients with multivessel coronary artery disease.Zimmermann FM, De Bruyne B, Pijls NHJ, Desai M, Oldroyd KG, Reardon MJ, Wendler O, Woo J, Yeung AC, Fearon WF.Am Heart J. 2019 Apr 29;214:156-157. doi: 10.1016/j.ahj.2019.04.012.

Author Correction: Novel mutations in PIEZO1 cause an autosomal recessive generalized lymphatic dysplasia with non-immune hydrops fetalis.Fotiou E, Martin-Almedina S, Simpson MA, Lin S, Gordon K, Brice G, Atton G, Jeffery I, Rees DC, Mignot C, Vogt J, Homfray T, Snyder MP, Rockson SG, Jeffery S, Mortimer PS, Mansour S, Ostergaard P. Nat Commun. 2019 Apr 26;10(1):1951. doi: 10.1038/s41467-019-09905-4.

Treatment of atrial fibrillation with concomitant coronary or peripheral artery disease: Results from the outcomes registry for better informed treatment of atrial fibrillation II.Inohara T, Shrader P, Pieper K, Blanco RG, Allen LA, Fonarow GC, Gersh BJ, Go AS, Ezekowitz MD, Kowey PR, Reiffel JA, Naccarelli GV, Chan PS, Mahaffey KW, Singer DE, Freeman JV,Steinberg BA, Peterson ED, Piccini JP; ORBIT AF Patients and Investigators. Am Heart J. 2019 Apr 24;213:81-90. doi: 10.1016/j.ahj.2019.04.007

Impact of iodine concentration and iodine delivery rate on contrast enhancement in coronary CT angiography: a randomized multicenter trial (CT-CON).Rengo M, Dharampal A, Lubbers M, Kock M, Wildberger JE, Das M, Niezen A, van Tilborg F,Kofflard M, Laghi A, Krestin G, Nieman K.Eur Radiol. 2019 Apr 23. doi: 10.1007/s00330-019-06196-7.

Body composition and atrial fibrillation: a Mendelian randomization study.Tikkanen E, Gustafsson S, Knowles JW, Perez M, Burgess S, Ingelsson E.Eur Heart J. 2019 Apr 21;40(16):1277-1282. doi: 10.1093/eurheartj/ehz003.

The Impact of Prescribed Fire versus Wildfire on the Immune and Cardiovascular Systems of Children.Prunicki M, Kelsey R, Lee J, Zhou X, Smith E, Haddad F, Wu J, Nadeau K.Allergy. 2019 Apr 19. doi: 10.1111/all.13825.

Comparison of Ideal Cardiovascular Health Attainment and Acculturation among Asian Americans and Latinos.Rodriguez F, Echeverría SE, Pentakota SR, Amadi C, Hastings KG, Palaniappan LP.Ethn Dis. 2019 Apr 18;29(2):287-296. doi: 10.18865/ed.29.2.287.

LIMPRINT: Elucidating the Global Problem of Lymphedema.Rockson SG.Lymphat Res Biol. 2019 Apr;17(2):119-120. doi: 10.1089/lrb.2019.29062.sr.

Substantial Cardiovascular Morbidity in Adults With Lower-Complexity Congenital Heart Disease.Saha P, Potiny P, Rigdon J, Morello M, Tcheandjieu C, Romfh A, Fernandes SM, McElhinney DB, Bernstein D, Lui GK, Shaw GM, Ingelsson E, Priest JR. Circulation. 2019 Apr 16;139(16):1889-1899. doi: 10.1161/CIRCULATIONAHA.118.037064.

Personalized medicine in cardio-oncology: the role of induced pluripotent stem cell.Sayed N, Ameen M, Wu JC.Cardiovasc Res. 2019 Apr 15;115(5):949-959. doi: 10.1093/cvr/cvz024.

Myocardial viability of the peri-infarct region measured by T1 mapping post manganese-enhanced MRI correlates with LV dysfunction.Tada Y, Heidary S, Tachibana A, Zaman J, Neofytou E, Dash R, Wu JC, Yang PC.Int J Cardiol. 2019 Apr 15;281:8-14. doi: 10.1016/j.ijcard.2019.01.101.

Physical activity, sleep and cardiovascular health data for 50,000 individuals from the MyHeart Counts Study.Hershman SG, Bot BM, Shcherbina A, Doerr M, Moayedi Y, Pavlovic A, Waggott D, Cho MK, Rosenberger ME, Haskell WL, Myers J, Champagne MA, Mignot E, Salvi D, Landray M, Tarassenko L, Harrington RA, Yeung AC, McConnell MV, Ashley EA.Sci Data. 2019 Apr 11;6(1):24. doi: 10.1038/s41597-019-0016-7.

A toolkit for genetics providers in follow-up of patients with non-diagnostic exome sequencing.Zastrow DB, Kohler JN, Bonner D, Reuter CM, Fernandez L, Grove ME, Fisk DG; Undiagnosed Diseases Network, Yang Y, Eng CM, Ward PA, Bick D, Worthey EA, Fisher PG, Ashley EA, Bernstein JA, Wheeler MT.J Genet Couns. 2019 Apr;28(2):213-228. doi: 10.1002/jgc4.1119.

Finding missed cases of familial hypercholesterolemia in health systems using machine learningJuan M. Banda, Ashish Sarraju, Fahim Abbasi, Justin Parizo, Mitchel Pariani, Hannah Ison, Elinor Briskin, Hannah Wand, Sebastien Dubois, Kenneth Jung, Seth A. Myers, Daniel J. Rader, Joseph B. Leader, Michael F. Murray, Kelly D. Myers, Katherine Wilemon, Nigam H. Shah and Joshua W. Knowles.Npj Digital Medicine. 2019 Apr 11. doi: 10.1038/s41746-019-0101-5.

Single-Cell RNA Sequencing of Human Embryonic Stem Cell Differentiation Delineates Adverse Effects of Nicotine on Embryonic Development.Guo H, Tian L, Zhang JZ, Kitani T, Paik DT, Lee WH, Wu JC.Stem Cell Reports. 2019 Apr 9;12(4):772-786. doi: 10.1016/j.stemcr.2019.01.022.

Response by Itoga et al to Letter Regarding Article, "Association of Blood Pressure Measurements With Peripheral Arterial Disease Events".Itoga NK, Tawfik DS, Leeper NJ, Chang TI. Circulation. 2019 Apr 9;139(15):1855-1856. doi: 10.1161/CIRCULATIONAHA.119.039293.

New CENTERA Transcatheter Aortic Valve: Best of the Balloon-Expandable and Self-Expanding Valve Worlds?Yeung AC.JACC Cardiovasc Interv. 2019 Apr 8;12(7):681-683. doi: 10.1016/j.jcin.2019.02.024.

Identification of Factors Associated With Variation in US County-Level Obesity Prevalence Rates Using Epidemiologic vs Machine Learning Models.Scheinker D, Valencia A, Rodriguez F.JAMA Netw Open. 2019 Apr 5;2(4):e192884. doi: 10.1001/jamanetworkopen.2019.2884.

Developing a genomics rotation: Practical training around variant interpretation for genetic counseling students.Grove ME, White S, Fisk DG, Rego S, Dagan-Rosenfeld O, Kohler JN, Reuter CM, Bonner D; Undiagnosed Diseases Network, Ashley EA, Wheeler MT, Bernstein JA, Ormond KE, Hanson-Kahn AK. J Genet Couns. 2019 Apr;28(2):466-476. doi: 10.1002/jgc4.1094.

Stars in the Night Sky: iPSC-Cardiomyocytes Return the Patient Context to Drug Screening.Hnatiuk A, Mercola M.Cell Stem Cell. 2019 Apr 4;24(4):506-507. doi: 10.1016/j.stem.2019.03.013.

Outcomes with ambulatory advanced heart failure from the Medical Arm of Mechanically Assisted Circulatory Support (MedaMACS) Registry.Ambardekar AV, Kittleson MM, Palardy M, Mountis MM, Forde-McLean RC, DeVore AD, Pamboukian SV, Thibodeau JT, Teuteberg JJ, Cadaret L, Xie R, Taddei-Peters W, Naftel DC,Kirklin JK, Stevenson LW, Stewart GC. J Heart Lung Transplant. 2019 Apr;38(4):408-417. doi: 10.1016/j.healun.2018.09.021.

A toolkit for genetics providers in follow-up of patients with non-diagnostic exome sequencing.Zastrow DB, Kohler JN, Bonner D, Reuter CM, Fernandez L, Grove ME, Fisk DG; Undiagnosed Diseases Network, Yang Y, Eng CM, Ward PA, Bick D, Worthey EA, Fisher PG, Ashley EA, Bernstein JA, Wheeler MT 3rd. J Genet Couns. 2019 Apr;28(2):213-228. doi: 10.1002/jgc4.1119.

Impact of Hemodynamic Ramp Test-Guided HVAD Speed and Medication Adjustments on Clinical Outcomes.Uriel N, Burkhoff D, Rich JD, Drakos SG, Teuteberg JJ, Imamura T, Rodgers D, Raikhelkar J, Vorovich EE, Selzman CH, Kim G, Sayer G.Circ Heart Fail. 2019 Apr;12(4):e006067. doi: 10.1161/CIRCHEARTFAILURE.119.006067.

Years of Potential Life Lost Because of Cardiovascular Disease in Asian-American Subgroups, 2003-2012.Iyer DG, Shah NS, Hastings KG, Hu J, Rodriguez F, Boothroyd DB, Krishnan AV, Falasinnu T, Palaniappan L.J Am Heart Assoc. 2019 Apr 2;8(7):e010744. doi: 10.1161/JAHA.118.010744.

Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.Kranzler HR, Zhou H, Kember RL, Vickers Smith R, Justice AC, Damrauer S, Tsao PS, Klarin D, Baras A, Reid J, Overton J, Rader DJ, Cheng Z, Tate JP, Becker WC, Concato J, Xu K, Polimanti R, Zhao H, Gelernter J. Nat Commun. 2019 Apr 2;10(1):1499. doi: 10.1038/s41467-019-09480-8.

An orange calcium-modulated bioluminescent indicator for non-invasive activity imaging.Oh Y, Park Y, Cho JH, Wu H, Paulk NK, Liu LX, Kim N, Kay MA, Wu JC, Lin MZ. Nat Chem Biol. 2019 Apr 1. doi: 10.1038/s41589-019-0256-z.

Oral anticoagulation among atrial fibrillation patients with anaemia: an observational cohort study.Bonde AN, Blanche P, Staerk L, Gerds TA, Gundlund A, Gislason G, Torp-Pedersen C, Lip GYH, Hlatky MA, Olesen JB. Eur Heart J. 2019 Apr 1. pii: ehz155. doi: 10.1093/eurheartj/ehz155.

Opportunities and challenges for transcriptome-wide association studies.

Wainberg M, Sinnott-Armstrong N, Mancuso N, Barbeira AN, Knowles DA, Golan D, Ermel R, Ruusalepp A, Quertermous T, Hao K, Björkegren JLM, Im HK, Pasaniuc B, Rivas MA, Kundaje A. Nat Genet. 2019 Apr;51(4):592-599. doi: 10.1038/s41588-019-0385-z.

Serial Cardiac FDG-PET for the Diagnosis and Therapeutic Guidance of Patients With Cardiac Sarcoidosis.Ning N, Guo HH, Iagaru A, Mittra E, Fowler M, Witteles R.J Card Fail. 2019 Apr;25(4):307-311. doi: 10.1016/j.cardfail.2019.02.018.

Nanoparticle Therapy for Vascular Diseases.Flores AM, Ye J, Jarr KU, Hosseini-Nassab N, Smith BR, Leeper NJ.Arterioscler Thromb Vasc Biol. 2019 Apr;39(4):635-646. doi: 10.1161/ATVBAHA.118.311569.

Parvovirus B19-induced severe anemia in heart transplant recipients: Case report and review of the literature.Pinto NC, Newman C, Gomez CA, Khush KK, Moayedi Y, Lee R, Teuteberg JJ, Montoya JG. Clin Transplant. 2019 Apr;33(4):e13498. doi: 10.1111/ctr.13498.

Extended-duration betrixaban versus shorter-duration enoxaparin for venous thromboembolism prophylaxis in critically ill medical patients: an APEX trial substudy.Chi G, Gibson CM, Kalayci A, Cohen AT, Hernandez AF, Hull RD, Kahe F, Jafarizade M, Sharfaei S, Liu Y, Harrington RA, Goldhaber SZ. Intensive Care Med. 2019 Apr;45(4):477-487. doi: 10.1007/s00134-019-05565-6.

Developing a genomics rotation: Practical training around variant interpretation for genetic counseling students.Grove ME, White S, Fisk DG, Rego S, Dagan-Rosenfeld O, Kohler JN, Reuter CM, Bonner D; Undiagnosed Diseases Network, Wheeler MT, Bernstein JA, Ormond KE, Hanson-Kahn AK. J Genet Couns. 2019 Apr;28(2):466-476. doi: 10.1002/jgc4.1094.

Interpreting Neurologic Outcomes in a Changing Trial Design Landscape: An Analysis of HeartWare Left Ventricular Assist Device Using a Hybrid Intention to Treat Population.Mahr C, Thinh Pham D, Mokadam NA, Silvestry SC, Cowger J, Kiernan MS, D'alessandro DA, Coglianese EE, Faraz Masood M, Kormos RL, Jacoski MV, Teuteberg JJ.ASAIO J. 2019 Mar/Apr;65(3):293-296. doi: 10.1097/MAT.0000000000000931.

Predictability in complex atrial arrhythmias: The N/N-1 algorithm to guide ablation of atrial tachycardias.Kaiser DW, Rogers AJ, Narayan SM.Heart Rhythm. 2019 Apr;16(4):562-563. doi: 10.1016/j.hrthm.2018.11.018.

Repair of Untreated Older Patients With Tetralogy of Fallot With Major Aortopulmonary Collaterals.Vaikunth SS, Bauser-Heaton H, Lui GK, Wise-Faberowski L, Chan FP, Asija R, Hanley FL, McElhinney DB. Ann Thorac Surg. 2019 Apr;107(4):1218-1224. doi: 10.1016/j.athoracsur.2018.11.016.

An Automated Algorithm to Quantify Collagen Distribution in Aortic Wall.Nguyen DM, Wagenhäuser MU, Mehrkens D, Adam M, Tsao PS, Ramasubramanian AK. J Histochem Cytochem. 2019 Apr;67(4):267-274. doi: 10.1369/0022155418814231.

Efficacy and safety of rivaroxaban vs. warfarin in patients with non-valvular atrial fibrillation and a history of cancer: observations from ROCKET AF.Chen ST, Hellkamp AS, Becker RC, Berkowitz SD, Breithardt G, Fox KAA, Hacke W, Halperin JL, Hankey GJ, Mahaffey KW, Nessel CC, Piccini JP, Singer DE, Patel MR, Melloni C.

Eur Heart J Qual Care Clin Outcomes. 2019 Apr 1;5(2):145-152. doi: 10.1093/ehjqcco/qcy040.

Evaluation of atrial septal defects with 4D flow MRI-multilevel and inter-reader reproducibility for quantification of shunt severity.Chelu RG, Horowitz M, Sucha D, Kardys I, Ingremeau D, Vasanawala S, Nieman K, Paul JF, Hsiao A.MAGMA. 2019 Apr;32(2):269-279. doi: 10.1007/s10334-018-0702-z.

Combination of Mean Platelet Volume and Neutrophil to Lymphocyte Ratio Predicts Long-Term Major Adverse Cardiovascular Events After Percutaneous Coronary Intervention.Choi DH, Kobayashi Y, Nishi T, Kim HK, Ki YJ, Kim SS, Park KH, Song H, Fearon WF.Angiology. 2019 Apr;70(4):345-351. doi: 10.1177/0003319718768658.