INDEX

Volume 174, July—September 1970

Abrams, W. B., see Mal,mfors, T., 99Acetaldehyde, inhaled, in man, retention of, 14Acetazolamide, altered absorption of drugs from

rat small intestine by carbonic anhydrase inhibition after pretreatment with, 177

Acetohydroxamate, excretion and metabolism inmice, 239

Acetylcholineblood flow responses to in dog, effects of etha

crynic acid on, 159contraction of denervated rat diaphragm, ef

fects of fadiitatory drugs on, 550effects in muscles of guinea pig, 560in innervated muscle subjected to prolonged

pharmacologic nerve block, absence of supersensitivity to, 133

measuring nanogram quantities by pyrolysisgas chromatography, demonstration in effluents from rat phrenic nerve-diaphragm preparation, 337

release from innervated and denervated diaphragm, 346

Acetaldehyde, alcohol and, augmentation ofalkaloid formation from dopamine by, 401

Acetazolamide-treated rats, tissue acid-base balance in, 535

Adams, H. J., see Boyce, R. N., 1Adenosine triphosphatase, (Na + K)-activated,

cation transport and, changes produced bychronic administration of ethanol, 330

Adipose tissue, rat, effect of SKF 525A on dis.tribution of carbon tetrachloride in, 232

Adrenergic blocking agents, alpha and beta,lidocaine, hexamothonium and, effects onpulmonary veins in intact dogs, 487

Adrenergic nervesmechanism of action of 6-hydroxydopamine on,

111peripheral, differentiation of norepinephrine

storage compartments in, 357rat, effects of debrisoquin and bretylium on, asrevealed by fluorescence histochemistry, 99

Agonistsdopamino and norepinephrine, conformational

differences derived from molecular orbitaltheory, 94

ganglionic, antagonists and, effect on cardiacsympathetic ganglia of dog, 45

Albutoin, pharmacologic interactions with otheranticonvulsant drugs, 450

Alcoholacetaldehyde and, augmentation of alkaloid

formation from dopamine by, 401

changes in cation transport and (Na + K)-activated adenosine triphosphatase producedby, 330

Alkaloidformation from dopamine, augmentation by

alcohol and acetaldehyde in vitro, 401metabolite of dopamine in vitro, 388

Alkon, D. L., Schmidt, D. E., Green, J. P. andSzilagyi, P. I. A. : The release of acetylcholinefrom the innervated and denervated diaphragm, 346

Alkon, D. L., see Schmidt, D. E., 337Amides, physiologic disposition of short chain

aliphatic hydroxamates in mice, excretion andconversion to, 239

Amines, sympathornimetic, in isolated nictitatingmembrane of cat, intraneuronal and extraneuronal accumulation of, 290

p-Aininohippurate, uptake by renal cortical slices,effect of penicillin on, 152

Amphetamine, metabolism and stereotype behavior in rat, effects of haloperidol and chiorpromazine on, 428

i-Amphetamine, oxidation in fetal and newbornswine, 185

Amphibian, red cells, structural requirements forhemolysis by phenylhydrazine derivatives in,463

Amyltrimethylammoniuin, effect on cardiacsympathetic ganglia of dog, 45

Androgen(s)antianesthetic activity of, 478impairment of action by morphine, 211

Anesthesia, inhibition by steroids, 478Angiotensin

central effect of, release of pituitary pressermaterial, 27

effects of SKF 525Aon responses in aortic stripsto, 500

potentiation by [4,4'-biphenylenebis(2-oxoethylene)@bisR2,2-diethoxyethyl) dimethylammonium bromide] (DMAE) of sympathetic

component of vasopressor response to, 35Antagonists, ganglionic, agonista and, effect on

cardiac sympathetic ganglia of dog, 45Antidiuretic hormone, polydipsia and, interaction

of central neurons with angiotensin and release of, 27

Aortic strips, selective blockade of potassiuminduced contractions by @-diethylaminoethyldiphenylpropylacetate (SKF 525A) in,500

567

568 INDEX

Arrhythmias, cardiac, effective suppression of bylidocaine hydrochloride, 1

Atoms, pattern of, examination of preferred conformation of dopamine derived from molecularorbital theory and comparison with conformation of norepinephrine, 94

Atria, kitten, isolated, graded responses due toblockade of conduction by cetyltrimethylammonium bromide (CTAB) in, 509

Atropine, effect on muscarinic agonists in dog, 45Autonomic ganglia, rats, localization of depletion

sensitive and depletion-resistant norepinephrine storage sites in, 56

Autonomic nervous system, canine, distribution ofhistamine in, 123

Backstrom, T., see Goldstein, M., 77Barbital, effect on percent urinary recovery of

acetohydroxamate, formohydroxainate, propionohydroxamate and isobutyrohydroxamate in mice, 239

Bartakovits, P., see Pendleton, R. G., 421Behavior, stereotype, amphetamine, metabolism

and, in rat, effects of haloperidol and chior‘¿�promazineon,428Behensohn, H., see Mans, J. W., 381Bernstein, J. C. and Israel, Y. : Active transport

of Rb― in human red cells and rat brainslices, 323

Bernstein, J. C., see Israel, Y., 330Bile, levels of harmine metabolites in, 456Biosynthesis, catecholamine, in rat brain cortex

slices, effect of ouabain on, 77[4, 4' -Biphenylenebis (2-oxoethyleno)]bis((2,2-di

ethoxyethyl) dimethylammonium bromide](DM.AE), potentiation of sympathetic cornponent ox vasopressor response to angiotensinby, 35

Black, I. B. : Regulation of hepatic tyrosinetransaminase in vivo through interaction ofnorcpinophrine and the pyridoxal phosphateco-factor, 283

Blackburn, W. H., see Wallin, R. F., 276Blood

disappearance of pentobarbital from, afterspironolactone or ethylestrenol, 473

flows, renal and femoral, of dog, effects ofethacrynic acid on, 159

levels of lidocaine hydrochloride in dogs, oralabsorption and disposition kinetics, 1

pressure and flow, in dog, responses to epinephrine and isoproterenol, actions of orgotamine, 315

pressure, dog, effect of tyramine on, blockadeby cocaine, 35

pressure, rats, effect of angiotensin on, 27pressure, rats, effects of two analogs of oxytocin

on, 541

rat, effect of SKF 525A on distribution of carbontetrachloride in, 232

Borzelleca, J. F. and Putney, J. W., Jr. : A modelfor the movement of salicylate across theparotid epithelium, 527

Boyd, G. N., see Kaisner, S., 500Boyce, R. N., Adams, H. J. and Duce, B. R. : Oral

absorption and disposition kinetics of lidocaine hydrochloride in dogs, 1

Braincortex slices, rat, effect of ouabain on catechol

amine biosynthesis in, 77norepinephrine and dopamine, effect of 6-

hydroxydopamine on, evidence for selectivedegeneration of catecholamine neurons, 413

rat, disappearance of amphetamine from, 428rat, effect of SKF 525A on distribution of carbon

tetrachloride in, 232rat, efflux of chiorpromazine and trifluoperazine

from, 20slices, rat, effect of chronic administration -of

ethanol on accumulation of potassium andRb―by, 330

slices, rat, human red cells and, active transportof Rb' in, 323

tissue cell pH values in, 535Brainstem

rat, homogenates, production of tetrahydropapaveroline in, 401

rat, homogenates, tetrahydropapaveroline asmetabolic product of dopamine in, 388

Breese, G. R. and Traylor, T. D. : Effect of 6-hydroxydopamine on brain norepinephrineand dopamine : Evidence for selective degeneration of catecholamine neurons, 413

Bretylium, debrisoquin and, effects on adrenergicnerves as revealed by fluorescence histochemistry, 99

Bretylium tosylate, blockade of DMAE-inducedpotentiation of pressor response to angio‘¿�tensinby,35

Brody, M. J., see Ryan, M. J., 123Burke, J. P., see Van Orden, L. S., III, 56, 357Burnstock, G., see Furness, J. B., illButoxamine, beta adrenergic blocking agent, ef

feet on pulmonary vessels, 487n-Butyraldoxime, inhibitor of metabolism and

natural ethanol preference of C57BLmice, 434

Cabana, B. E. and Gessner, P. K. : The kinetics ofchioral hydrate metabolism in mice and theeffect thereon of ethanol, 260

Cabana, B. E., see Gessner, P. K., 247Calcium

effecl@on inhibitory actions of manganese onnorepinophrine release from aplonic nerves ofcats, 72

569INDEX

-induced contractions in aortic strips, responsesto SKF 525A, 500

movements in frog sartorius muscle, effects oflanthanum on, ‘¿�517

Caffeine, responses in frog @artoriusmuscle, offects of lanthanum on, 517

Campbell, G. R., see Furness, J. B., 111Carbachol, effects in muscles of guinea pig, 560Carbon monoxide, effect on cyclophosphamido

activating enzyme, 206Carbon tetrachloride, distribution in rats, effect

of SKF 525A on, 232Carbonic anhydrase, inhibition, altered absorp

tion of drugs from rat small intestine by, 177Cardiac arrhythmias, effective suppression of by

lidocaine hydrochloride, 1Cardiac eympathetié ganglia, dog, effect of-@ ganglionic agonists and antagonists on, 45

Cat(s) •¿�inhibitory effect of manganese on norepinoph

rime release from splenic nerves of, 72intraneuronal and extraneuronal accumulation

of sympathomimetic amines in isolatednictitating membrane of, 290

Catecholamine(s)biosynthesis in rat brain cortex slices, effect of

ouabain on, 77dopamine and norepinephrine, conformational

differences derived -from molecular orbitaltheory, 94

effect on enzyme induction by pyridoxal phosphate' co-factor in rat, 283

influence of propranolol and ICI 50,172 oncardiovascular actions of, modification byergotamine, 315

myocardial, effects of hypoxia and hypercarbia‘¿�on,307neurons, evidence for selective degeneration of,

effect of 6-hydroxydopamine on brain norepinephrine and dopamine, 413

C14-Catecholamine, level in whole mouse afterC14-dihydroxyphenylalanine (C14-dopa), 351

Cateèhol-O-methyltransferase3,5.@dihydroxy4-methoxybensoic acid and re

lated compounds, a new class of inhibitors of,83 -

effect on intraneuronal and extraneuronalaccumulation of sympathomimetic amines inisolated nictitating membrane of cat, 290

Cation transport, (Na + K)-activated adenosinetriphosphatase and, changes produced bychronic administration of ethanol, 330

Cats, C. S., Juchau, M. R. and Yaffe, S. J. : Effects of iron, riboflavin and iodide deficiencieson hepatic drug-metabolizing enzyme systems, 197

Cell(s)“¿�chromaffin,―norepinephrine storage site in

autonomic ganglia of rat, resistant to dopletion by reserpine or a-methyl-m-tyrosine,56

red, amphibian, structural requirements forhemolysis by phenylhydrazine derivatives in,463

red, human, rat brain slices and, active transport of Rb86in, 323

Central nervous systemdepletion of dopazninein, 413gastric antisecretory action of desmethyl

imipramine in, 421interaction of angiotensin with, 27

Cetyltrimethylammonium bromide (CTAB),graded responses in isolated kitten atria dueto blockade of conduction by, 509

Chan, W. Y. and du Vigneaud, V. : Natriurotic,diuretic and anti-arginine-vasopressin (ADH)effects of two analogs of oxytocin: [4-leucinejoxytocin and [2,4-diisoleucine]-oxytocin, 541

Chloral hydrateethanol and, study of interaction of hypnotic

and toxic effects of, 247metabolism in mice, kinetics and effect thereon

of ethanol, 260Chlorpromazine

haloperidol and, effects on amphetamine metabolism and stereotype behavior in rat, 428

trifluoperazine and, efflux from rat brain, 20Chou, C., see Wurtman, R. J., 351“¿�Chromaffin―cell, norepinephrine storage site in

autonomic ganglia of rat, resistant to depletion by reserpine or a-methyl-m-tyrosine,56

Cigarette smoking, industrial situations and,respiratory handling of acetaldehyde in man,14

Cobb, J. L. S., see Furness, J. B., 111Cocaine

effect on intraneuronal and extraneuronalaccumulation of sympathomimetic amines inisolated nictitating membrane of cat, 290

potentiation of sympathetic component ofvasopressor response to angiotensin by, 35

Cohen, J. L. and Jao, J. Y. : Enzymatic basis ofcyclophosphamide activatiOn by hepaticinicrosomes of the rat, 206

Compound 48/80, effect on distribution of histamine in canine autonomic nervoussystem, 123

Connor, J. D., see Severs, W. B., 27Cortex

slices, rat brain, effect of ouabain on catecholamine biosynthesis in, 77

slices, rat, effect of chronic' administration ofethanol on accumulation of potassium andRb' by, 330

slices, rat, human red cells and, active transportof Rb8' in, 323

570 INDEX

slices, renal, uptake of p-aminohippurate by,effect of penicillin on, 152

Costa, E., see Spano, P. F., 20Creveling, C. R., see Nikodejevic, B., 83Curare-like compounds, affinity of and potency in

blocking neuromuscular transmission, 560Cycloheximide

effect on increase in p-aminohippurate inducedby penicillin, 152

effect on tyrosine transaminase activity in rat,283

Cyclophosphamide, activation by hepatic microsomes of rat, enzymatic basis of, 206

Cyclopropane, halothane and, peripheral vasculareffects in dog, 169

Cytochrome c, effect on cyclophosphamideactivating enzyme, 206

Cytocb.romes, microsomal, effects of iron, riboflavin and iodide deficiencies on, 197

Daly, J. W., see Nikodejevic, B., 83Davis, J. M., see Lemberger, L., 428Davis, L. E., see Short, C. R., 185Davis, V. E., Walsh, M. J. and Yamanaka, Y.:

Augmentation of alkaloid formation fromdoparnine by alcohol and acetaldehyde invitro, 401

Davis, V. E., see Walsh, M. J., 388Debrisoquin, bretylium and, effects on adrenergic

nerves as revealed by fluorescence histochemistry, 99

Docamethonium, effects in muscles of guinea pig,560

Desmethylimiprarnine(DM1), studies indicating central antisecretory

site of action for, 421influence on effects of debrisoquin, bretylinm

and nialamide on adrenergic nerves as revealed by fluorescence histochemistry, 99

C'4-Dextroamphetamine sulfate , altered absorption from rat small intestine by carbonicanhydrase inhibition after pretreatment withacetazolamide,177

Diaphragmmuscle, guinea pig, effect of curare-like corn

pounds on, 560chronically denervated, rat, fadiitatory drug

action on, 550rat, innervated and denervated, release of

acetylcholine from, 346$-Diethylaminoethyldiphonylpropylacetate (SKF

525A), selective blockade of potassium-induced contractions of aortic strips by, 500

Dietzel, W., Emerson, T. E., Jr. and Massion,W. H. : Peripheral vascular effects of cyclopropane and halothane in the dog, 169

H@-Dihydromo@hine, in tolerant and nontolerantrat, maternal and fetal distribution of, 9

3,5-Dihydroxy-4-methoxybenzoic acid, relatedcompounds and, a new class of inhibitors ofcatechol-O-methyltransferase, 83

C14-Dihydroxyphenylalathne (C'4-dopa), fate inwhole mouse, 351

[2,4-Diisoleucine]-oxytocin, analog of oxytocin,natriuretic , diuretic and anti-arginine-vasopressin (ADH) effects of, 541

1, 1 - Dimethyl - 4 - phenylpiperazinium, effect oncardiac sympathetic ganglia of dog, 45

Dimethyl tubocurarine, effects in muscles ofguinea pig, 560

Diphenylhydantoin, pharmacologic interactionsof albutoin with, 276

DiStefano, V., see Slotkin, T. A., 456Dixon, W., see Kirpekar, S. M., 72DMAE [4,4'-biphenylenebis(2-oxoethylene)Jbis

[(2,2-diethoxyothyl) dimethylammonium bromidej, potentiation of sympathetic cornponent of vasopressor response to angiotensinby, 35

Dog(s)autonomic nervous syntern of, distribution of

histamine in, 123effect of ganglionic agonists and antagonists on

cardiac sympathetic ganglia of, 45intact, effects of lidocaine, hexamethonium and

alpha and beta adrenergic blocking agents onpulmonary veins in, 487 -

model for movement of salicylate across parotidepithelium in, 527

oral absorption and disposition kinetics oflidocaine hydrochloride in, 1 -

peripheral vascular effects of cyclopropane andhalothane in, 169

potentiation by DMAE and cocaine of sympathetic component of vasopressor response toangiotensin in, 35

responses to epinephrine and isoproterenol,actions of ergotamine on, 315

selective renal vascular effects of ethacrynicacid in, 159

studies indicating central antisocretory site ofaction for desmethylimipramine (DM1) in, 421

C14-Dopa (C'4-dihydroxyphenylalanine), fate inwhole mouse, 351

Doparninealkaloid formation from, augmentation by

alcohol and acetaldehyde in vitro, 401brain, norepinephrine and, effect of 6-hydroxy

doparnine on, evidence for selective degeneration of catecholamine neurons, 413

effect on enzyme induction by pyridoxal phosphate co-factor in rat, 283

preferred conformation from molecular orbitaltheory,94

C'-Dopamine, formation from C1-tyrosine inrat brain cortex slices, effect of ouabain on, 77

INDEX 571

Draskóczy, P. R. and Trondelonburg, U. : Intraneuronal and extraneuronal accumulation ofsympathomirnetic amines in the isolatednictitating membrane of the cat, 290

Drosol, P. E., see Kadowitz, P. J., 509Duce, B. R., see Boyes, R. N., 1Duodenum, rat, intestinal loops in, altered

absorption of drugs by carbonic anhydraseinhibition after pretreatment with acetazolamide, 177

Edrophonium, effects on phrenic nerve-diaphragmpreparation of rat, 550

Egle, J. L., Jr. : Retention of inhaled acetaldehydein man, 14

Emerson, T. E., Jr., see Dietzel, W., 169Emesis, in dogs, after administration of lidocaine

hydrochloride, 1Enzyme(s)

activity, drug-metabolizing, in swine, perinataldevelopment of, 185

basis of cyclophosphaniide activation by hepaticmicrosomes of rat, 206

induction by pyridoxal phosphate co-factor inrat, 283

systems, drug-metabolizing, hepatic, in mice,effects of iron, riboflavin and iodide doficiencies, 197

Epinephrineactions of ergotarnine on responses of dog to,

315effects of hypoxia and hypercarbia on, 307

Ergotarnine, influence of propranolol and ICI50,172 on cardiovascular actions of catecholamines as modified by, 315

Ethacrynic acid, selective renal vascular effectsof, 159

Ethanolchanges in cation transport and (Na + K)-

activated adonosine triphosphatase producedby chronic administration of, 330

chioral hydrate and, study of interaction ofhypnotic and toxic effects of, 247

kinetics of chloral hydrate metabolism in miceand effect thereon of, 260

metabolism and natural preference, in C57BLmice, inhibition by n-butyraldoxime, 434

Ethylestrenol, spironolactone or, suppression bynucleic acid- and protein-synthesis inhibitorsof drug detoxication induced by, 473

Eye, iris, albino rat, effects of debrisoquin,bretylium and nialamide on uptake, storage,metabolism and release of norepinephrine asrevealed by fluorescence histochemistry, 99

produced by 6-hydroxydoparnino in vasdeferens, 111

differentiation of norepinephrine storage cornpartments in peripheral adrenergic nerves by,357

effects of debrisoquin and bretylium on adrenorgic nerves as revealed by, 99

Fetuses, rat, distribution of H-dihydromorphinein, 9

Fiahbein, W. N. and Streeter, C. L. : Physiologicdisposition of short chain aliphatic hydroxarnates in the mouse. I. The one-throughfour carbon hydroxarnates : Excretion andconversion to arnides, 239

Flacke, W. and Fleisch, J. H. : The effect ofganglionic agonists and antagonists on thecardiac sympathetic ganglia of the dog, 45

Fleisch, J. H., see Flacke, W., 45Flores, G. and Frieden, E. : Structural require

rnents for the hernolytic effect of phenylhydrazine derivatives on amphibian red cells,463

Fluorescence histochemistryFalck-Hillarp method, cellular studies of

sympathetic denervation produced by 6-hydroxydopamine in vas deferens, 111

Falck-Hillarp method, differentiation of norepinephrmnestorage compartments in peripheraladrenergic nerves by, 357

Falck-Hillarp method, effects of debrisoquinand bretylium on adrenergic nerves -as revealed by, 99

Formohydroxamate, excretion and metabolism inmice, 239

Freeman, S. E. and Turner, R. J. : Faciitatorydrug action on the isolated phrenic nervediaphragm preparation of the rat, 550

Frieden, E., see Floros, G., 463Frog

sartorius muscle of, treated with tetraalkylammoniuin ions, potassium fluxes in, 141

sartorius muscle, site of action of lanthanum in,517

Furness, J. B., Campbell, G. R., Guard, S. M.,Maimfors, T., Cobb, J. L. S. and Burnstock,G. : Cellular studies of sympathetic denervation produced by 6-hydroxydopaxnine in thevas deferens, 111

Gallamine, effects in muscles of guinea pig, 560Ganglia

autonomic, rats, localization of depletionsensitive and depletion-resistant norepinephrine storage sites in, 56

sympathetic, cardiac, dog, effect of ganglionicagonists and antagonists on, 45

Garrett, J., see Osswald, W., 315Falck-Hillarp fluorescence histochemical method

cellular studies of sympathetic denervation

572 @DEX

Gessner, P. K. and Cabana, B. E. : A study of theinteraction of the hypnotic effects and of thetoxic effects of chloral hydrate and ethanol,247

Gessner, P. K., see Cabana, B. E., 260Geyer, M., see Van Orden, L. S., III, 56Gillard, S. M., see Furness, J. B., 111Glutathione, hepatic, sulfobrômophthalein me

tabolism and excretion in rats with iodomethane-induced depletion of, 221

Glutethimide, serum half-life of, determinants inintoxicated patients, 450

Glycogen, in pig liver at-various ages after birth,correlation with developrnent of drug-metabolizing eiizyrne activity, 185 - -

Golciman, R. H. and HarrisOn,D. C. : The effectsof hypoxia and hypercarbia on myocardialcatecholamines, 307

Goldstein, M., Ohi, Y. and Backstrom, T. : The. - effect of ouabain on catecholamine biosynthe

sis in rat brain cortex slices, 77Granular vesicles, norepinephrine storage -site in

autonornic ganglia of rat, sensitive to depletion by reserpine and a-methyl-m-tyrosine,@56

Green, J. P.see Alkon, D. L., 346see Schmidt, D. E., 337

Greenberg, S. and Long, J. P.: Potentiation by[4, 4'-biphenylenebis(2-oxoethylene)]bia[(2, 2-

- diethoxyethyl)dimethylammothumbromide](DMAE) of the sympathetic component of thevasopressor response to angiotensin, 35

Guanethidine, blockade of DMAE-induced potentiation of pressor response to angiotensinby, 35

GUimarAcs, S., see Osswald, W., 315Guinea pig, affinity and potency of curare-like

compounds in blocking neuromuscular transmission in, 560

Haloperidol, chlorpromazine and, effects onamphetamine metabolism and stereotype behavior in rat, 428

Ealothane, cyclopropane and, peripheral vasculareffects in dog, 169

Harmine, metabolism in rat, model of, 456Harrison, D. C., see Goldman, R. H., 307Heart

arrhythmias, effective suppression by lidocainehydrochloride, 1

dog, effect of ganglionic agonists and antagonists on sympathetic ganglia, 45

dog, responses to epinephrmne and isoproterenol,actions of ergotarnine, 315

sympathetic nervous system, responses tohypoxia and hypercarbia in rats, 307

Hemoglobin, spectrum, amphibian, changes produced by hemolytic drugs in, 463

Hemolysis, by phenylhydrazine derivatives inamphibian red cells, structural requirementsof,463 -

Hexamethoniumeffect on DMAE-induced potentiation of

pressor response to angiotensin and norepinephrmne in dogs, 36

effect on response to ganglionic agonists indog, 45

influence on elevation of mean blood pressure inrats by angiotensin, 27

lidocaine, alpha and beta adrenergic blockingagents and, effects on pulmonary veins in intact dogs, 487

Hexobarbitaleffect on cyclophosphamide-activating enzyme,

206oxidation in fetal and newborn swine, 185sleeping times, effects of iron, riboflavin and

iodide deficiencies on, 197Hexyltrimethylammonium, effect on cardiac

sympathetic ganglia of dog, 45Hirsch, G. H. and Hook, J. B. : Stimulation of

renal organic acid transport and protein synthesis by penicillin, 152

Histaminedistribution in canine autonomic nervous sys

tern, 123effects of SKF 525A on responses in aortic stripe

to, 500Hook, J. B., see Hirsch, G. H., 152Hollands, M., see Kadowitz, P. J., 509Hormone(s)

antidiuretic, polydipsia and, interaction ofcentral neurons with angiotensin and releaseof, 27

inhibition of anesthesia induced by progesteroneor pentobarbital, 478

steroid, hydroxylation of, by rat liver microsomes, effect of morphine administration on,211

Hosoya, E., see Kato, R., 211Humans

glutethimide intoxication in, determinants ofserum half-life, 450

normal male, kinetic study of disposition ofcirculating norepinephrmne in, 381

Hydroxamates, short chain aliphatic, in mice,physiologic disposition of, excretion and conversion to amides, 239

6-Hydroxydoparnineeffect on brain norepinephrmne and dopamine,

evidence for selective degeneration of catecholamine neurons, 413

in vas deferens, cellular studies of sympatheticdenervation produced by, 111

573INDEX

p-Hydroxymercuribenzoate, effect on cyclophosphamide-activating enzyme, 206

5-Hydroxytryptamine, effects of SKF 525A onresponses in aortic strips to, 500

Hyman, A. L. : The effects of lidocaine, hexamethonium and alpha and beta adrenergicblocking agents on the pulmonary veins in intact dogs, 487

Hypercarbia, hypoxia and, effects on myocardialcatecholamines, 307

Hypoxia, hypercarbia and, effects on myocardialcatecholamines, 307

ICI 50,172, propranolol and, influence on cardiovascular actions of catecholamines as modifiedby ergotamine, 315

bum, rat, intestinal loops in, altered absorptionof drugs by carbonic anhydrase inhibitionafter pretreatment with acetazolamide, 177

Intestine, small, rat, altered absorption of drugsby carbonic anhydrase inhibition from, 177

Iodide, deficiencies, iron, riboflavin and, effectson -hepatic drug-metabolizing enzyme ayetems, 197

lodomethane-induced depletion of hepatic glutathione, sulfobromophthalein metabolism andexcretion in rats with, 221

Ions, tetraalkylammonium, potassium fluxes infrog sartorius muscle treated with, 141

Irisalbino rat, effects of debrisoquin, bretyliuni and

nialamide on uptake, storage, metabolismand release of norepinephrmne as revealed by

- fluorescence histochemistr.y, 99

rat, disappearance of norepinephrine as viaualized by fluorescence histochemistry in, 357

Iron, deficiencies, riboflavin, iodide and, effectson hepatic drug-metabolizing enzyme eye

- tems, 197

Isobutyrohydroxainate , excretion and metabolismin mice, 239

Isoproterenol, actions of ergotamine on responsesof dog to, 315

Israel, Y., Kalant, H., LeBlanc, E., Bernstein, J.C. and Salazar, I. : Changes in cation transport and (Na + K)-activated adenosine tnphosphatase produced by chronic adininistration of ethanol, 330

Israel, Y., see Bernstein, J. C., 323

Jao, J. Y., see Cohen, J. L., 206Juchau, M. R., see Catz, C. S., 197

Kadowitz, P. J., Hollanda, M. and Dread, P. E.:Graded responses in isolated kitten atm dueto blockade of conduction by cetyltnimethylammonium bromide (CTAB), 509

Kalant, H., see Israel, Y., 330

Kalsner, S., Nickerson, M. and Boyd, G. N.:Selective blockade of potassium-inducedcontractions of aortic strips by j9-diethylaminoethyldiphenylpropylacetate (SKF525A), 500

Kato, R., Takahashi, A., Ohshima, T. and Hosoya,E. : Effect of morphine administration on thehydroxylation of steroid hormones by rat livermicrosomes, 211

Kidneyfailure, effect on serum half-life of glutethimide,

450organic acid transport and protein synthesis,

stimulation by penicillin, 152pig, peninatal development of drug-metaboliz

ing enzyme activity, 185selective vascular effects of ethacrynic acid, 159

Kier, L. B. and Truitt, E. B., Jr. : The preferredconformation of dopamine from molecularorbital theory, 94

Kinetic(s)analysis of blood levels in dogs after administra

tion of lidocaine hydrochloride, 1model for study of disposition of circulating

norepinephnine,369of chloral hydrate metabolism in mice and effect

thereon of ethanol, 260study of disposition of circulating norepineph

nine in normal male subjects, 381Kirpekar, S. M., Dixon, W. and Prat, J. C. : In

hibitory effect of manganese on norepinephrine release from the splenic nerves of cats, 72

Kishimoto, T., see McNay, J. L., 159Kitten, atnia, isolated, graded responses due to

blockade of conduction by cetyltnimethylammonium bromide (CTAB) in, 509

Koe, B. K. and Tenen, S. S. : Inhibiting action ofn-butyraldoxime on ethanol metabolism andon natural ethanol preference of C57BL mice,434

Kopin, I. J., see Lemberger, L., 428Krajny, M., see Solymoss, B., 473

Landis, D. H., see Maas, J. W., 381Lanthanum, site of action in frog sartonius muscle,

517Latissimus dorsi, guinea pig, effect of curare-like

compounds on, 560LB 46, beta adrenergic blocking agent, effect on

pulmonary vessels, 487LeBlanc, E., see Israel, Y., 330Lemberger, L., Witt, E. D., Davis, J. M. and

Kopin, I. J. : The effects of haloperidol andchiorpromazine on amphetamine metabolismand amphetamine stereotype behavior in rat,428

574 INDEX

[4-Leucine]-oxytocin, analog of oxytocin, natriuretic, diuretic and anti-arginine-vasopressin(ADH) effects of, 541

Lidocaine-blocked muscles, responses to succinylcholine

and d-tubocurarmne, 133hexamethonium, alpha and beta adrenergic

blocking agents and, effects on pulmonaryveins in intact dogs, 487

Lidocaine hydrochloride, in dogs, oral absorptionand disposition kinetics of, 1

Liverimpaired perfusion of, effect on serum half-life

of glutethimide, 450mice, effects of iron, riboflavin and iodide de

ficiencies on drug-metabolizing enzyme systome, 197

microsomes of rat, effect of morphine administration on hydroxylation of steroid hormones,211

microsomes of rat, enzymatic basis of cyclophosphamide activation, 206

pig, perinatal development of drug-metabolizingenzyme activity, 185

rat, effect of SKF 525A on distribution of carbontetrachlonide in, 232

rat, homogenates, production of tetrahydropapaveroline in, 401

rat, homogenates, tetrahydropapaveroline asmetabolic product of dopamine in, 388

rat, isolation of catechol-O-methyltransferasefrom, a new class of inhibitors, 83

regulation of tyrosine transaminase in vivothrough interaction of norepinephrmne andpyridoxal phosphate co-factor, 283

sulfobromophthalein metabolism and excretionin rats with iodomothane-induced depletionof glutathione in, 221

Lodoen, F. V., see Van Orden, L. S., III, 56, 357Long, J. P., see Greenberg, S., 35Lu, T. : Affinity of curare-like compounds and

their potency in blocking neuromusculartransmission, 560

Lung, veins, in intact dogs, effects of lidocaine,hexamethonium and alpha and beta adrenergicblocking agents on, 487

Mass, J. W.: A kinetic model for the study of thedisposition of circulating norepinephrmne, 369

Mass, J. W., Behensohn, H. and Landis, D. H. : Akinetic study of the disposition of circulatingnorepinephnine in normal male subjects, 381

Macko, E., see Spano, P. F., 20Maher, J. F. : Determinants of serum half-life of

glutethimide in intoxicated patients, 450Maimfors, T. and Abrams, W. B. : The effects of

debnisoquin and bretylium on adrenergic

nerves as revealed by fluorescence histochemistry, 99

Maimfors, T., see Furness, J. B., 111Man, retention of inhaled acetaldehyde in, 14Manganese, inhibitory effect on norepinephrine

release from splenic nerves of cats, 72Mann, W. A., see Pendleton, R. G., 421Marchand, C., McLean, S. and Plaa, G. L. : The

effect of SKF 525A on the distribution ofcarbon tetrachioride in rats, 232

Massion, W. H., US Dietzel, W., 169McLean, S., see Marchand, C., 232McNay, J. L. and Kishimoto, T. : Selective renal

vascular effects of ethacrynic acid, 159McNeil A-343, effect on cardiac sympathetic

ganglia of dog, 45Mocamylamine, effect on response to ganglionic

agonists in dog, 45Membrane, nictitating, isolated, of cat, intra

neuronal and extraneuronal accumulation ofsympathornimetic amines in, 290

Metabolismamphetamine, stereotype behavior and, in rat,

effects of halopenidol and chiorpromasine on,428

chloral hydrate, in mice, kinetics of, effectthereon of ethanol, 260

excretion and, of hydroxamates in mice, 239harmine, in rat, model of, 456natural ethanol preference and, in C5713L mice,

inhibition by n-butyraldoxime, 434of C14-dihydroxyphonylalanine (C'4-dopa) in

whole mouse, 351sulfobromophthalein, excretion and, in rats

with iodomethane-induced depletion of hepatic glutathione, 221

Metabolite(s)alkaloid, of doparnine in vitro, 388of harmine, levels in bile, urine and tissue, 456

Metanephrine, effect on intraneuronal and extraneuronal accumulation of sympathomimeticamines in isolated nictitating membrane ofcat, 290

3-Methylcholanthrene, effect on percent urinaryrecovery of acetohydroxamate, formohydroxamate, propionohydroxamate and isobutyrohydroxamate in mice, 239

a-Methyl-m-tyrosine, reserpine and, sensitivityor resistance of norepinephrmne storage sitesin autonomic ganglia of rat to depletion by,56

MiceC57BL, inhibition by n-butyraldoxime of

metabolism and natural ethanol preferencein, 434

effects of iron, riboflavin and iodide deficiencieson hepatic drug-metabolizing enzyme systems in, 197

INDEX 575@

kinetics of chioral hydrate metabolism in, offeet thereon of ethanol, 260

pharmacologic interactions -of albutoin withother anticonvulsant drugs in, 276

physiologic disposition of short chain eMphatichydroxaniates in, excretion and conversion toamides, 239

study of interaction of hypnotic and toxic effects of chloral hydrate and ethanol in, 247

vas deferens of, cellular studies of sympatheticdenervation produced by 6-hydroxydopaminein, 111 -

whole, fate of C'4-dihydroxyphenylalanine (C'sdopa) in, 351

Microsomeshepatic, of rat, effect of morphine adniinistra

tion on hydroxylation of steroid hormones by,211

hepatic, of rat, enzymatic basis of cyclophosphamide activation by, 206

Miller, D.. A., see Pendleton, R. G., 421Miya, T. S., see Schnell, R. C., 177Molecular orbital theory, preferred conformation

of doparnine from, 94Monoamine oxidase

effect on intraneuronal and extraneuronal accumulation of sympathomimetic amines inisolated nictitating membrane of cat, 290

inhibitors, debrisoquin and bretylium, effectson adrenergic nerves as revealed by fluorescence histochemistry, 99

Morphine, effect of acImini@tration on hydroxylation of steroid hormones by rat liver microsomos, 211

Muscle(s)guinea pig, effect of curare-like compounds on,

560rat, effect of SKF 525A on distribution of carbon

tetrachioride in, 232sartonius, frog, site of action of lanthanum in,

517sartorius, frog, treated with tetraalkylammo

nium ions, potassium fluxes in, 141skeletal, dog, peripheral vascular effects of

cyclopropane and halothane, 169skeletal, innervated, subjected to prolonged

pharmacologic nerve block, absence of supersensitivity to acetylcholine in, 133

smooth, of vas deferens, examination after injection with 6-hydroxydopamine, 111

tissue cell pH values in, 535

Napoli,M. D., see Walhin, R. F., 276Neff, N. H., see Spano, P. F., 20Neoprontosil, azo reduction in fetal and newborn

swine, 185

Nerve(s) •¿�- -adrenergic, mechanism of action of 6-hydroxy

dopamine on, 111adrenergic, peripheral, differentiation of norepi

nephrmnestorage compartments in, 357 -adronergic, rat, effects of debrisoquin and

bretyhium on, as revealed by fluoresce@icehistochemistry, 99

sciatic, rabbits, subjected to prolonged pharmacologic block, absence of supersensitivity toacetyicholine in innervated muscle, 133.

splenic, cats, inhibitory effect of mangax@es@onnorepinephrine release from, 72 - •¿�

Nerve-diaphragm preparationphrenic, rat, demonstration of acetyichohine in

effluents from, measuring nanogram quantities by pyrolysis-gas chromatography, 337

phrenic, rat, isolated, fadiitatory drug actionon,550 -

Nervous systemautonomic, canine, distribution of histamine in,

123central, depletion of dopamine in, 413central, gastric antisecretory action of desmeth

ylimipramine in, 421central, interaction of angiotensinwith, 27sympathetic, cardiac, responses to hypoxia and

hypercarbia in rats, 307Neurons

catecholamine, evidence for selective degeneration of, effect of 6-hydroxydopamine on brainnorepinephrmne and dopamine, 413

central, interaction of angiotensin with andrelease of antidiuretic hormone and polydipsia, 27

Nialarnide, effects on adrenergic nerves as revealedby fluorescence histochemistry, 99

Nickerson, M., see Kaisner, S., 500Nictitating membrane, isolated, of cat, intraneu

ronal and extraneuronal accumulation ofsympathomimetic amines in, 290

Nikodejevic, B., Senoh, S., Daly, J. W. andCrevehing, C. R. : Catechol-O-methyltransferase. II. A new class of inhibitors ofcatechol-O-methyltransferase; 3,5-dihydroxy4-methoxybenzoic acid and related compounds,83

p-Nitroaniaole, oxidation in fetal and newbornswine, 185

Noradrenaline, examination by fluorescencemethod of depletion of, 111

Norepinephrmneability of DMAE and cocaine to alter presser

response to, 35blood flow responses to in dog, effects of etha

crynic acid on, 159brain, dopamine and, effect of 6-hydroxydopa

576 fliDEX

mine on, evidence for selective degenerationof catecholamine neurons, 413

circulating, kinetic model for study of disposition of, 369

circulating, kinetic study of disposition of innormal male subjects, 381

conformational difference from pattern fordopamine derived frOm molecular orbitaltheory, 94

distribution in canine autonomic nervoussystem, 123

effects of hypoxia and hypercarbia on, 307effects of SKF 525A on responses in aortic strips

to, 500interaction with pyridoxal phosphate co-factor,

regulation of hepatic tyrosine transaminaseinvisethrough,283

intraneuronal and extraneuronal accumulationin isolated nictitating membrane of eat, 290

release from splenic nerves of cats, inhibitoryeffect of manganese on, 72

storage compartments in peripheral adrenergicnerves, differentiation of, 357

storage sites, depletion-sensitive and depletionresistant, in autonomic ganglia, localizationof, 56

uptake, storage, metabolism and release inadrenergic nerves as studied by fluorescencehistochemistry, effects of debrisoquin, brety11amand nialamide on, 99

C14-Norepinephnine,formation from C14-tyrosinein rat brain cortex slices, effect of ouabain on,77

Nucleic acid-synthesis inhibitors, protein- and,supression of drug detoxication induced byspironolactone or ethylestrenol by, 473

Nutrition, iron, riboflavin and iodide deficiencies,effects on hepatic drug-metabolizing enzymesystems in mice, 197

Oester, Y. T., 856Robert, E. D., 133Ohi, Y., see Goldstein, M., 77Ohahima, T., see Kato, R., 211Organic acid transport, renal, protein synthesis

and, stimulation by penicillin, 152Osswald, W., GuimarAes, S. and Garrett, J.:

Influence of propranolol and ICI 50, 172 on thecardiovascular actions of catecholamines asmodified by ergotamine, 315

Ouabain, effect on catecholamine biosynthesis inrat brain cortex slices, 77

Oxytocin, two analogs, natniuretic, diuretic andanti-arginine-vasopressin (ADH) effects of,541

Parotid epithelium, model for movement of salicylate across, 527

Pendleton, R. G., Bartokovita, P., Miller, D. A.,

Mann, W. A. and Ridley, P. T. : Studies mdieating a central antisecretory site of actionfor desmethylimipramine (DM1), 421

L-Penicillamine, effect on enzyme induction bypyridoxal phosphate co-factor in rat, 283

Penicillin, stimulation of renal organic acid transport and protein synthesis by, 152

Pentobarbitalanesthesia induced by, inhibition by steroids,- 478disappearance from blood after spironolactone

or ethylestrenol, 473Pharmacologic nerve block, prolonged, absence of

supersensitivity to acetylchohine in innervated muscle subjected to, 133

Phenethylamines, effective inhibitors of catechol0-methyltransferase, 83

Phenobarbitaleffect on cyclophosphamide-activating enzyme,

206pharmacologic interactions of albutoin with, 276

Phenolphthalein, glucuronidation in fetal and-newborn swine, 185

Phenoxybenzaminealpha adrenergic blocking agent, effect on pul

monary vessels, 487effect on intraneuronal and extraneuronal accu

mulation of sympathomimetic amines in isolated nictitating membrane of cat, 290

influence on elevation of mean blood pressure inrats by angiotensin,27 :

Phentolaminealpha adrenergic blocking agent, effect on pul

monary vessels, 487blockade of DMAE-induced potentiation of

presser response to angiotensin by, 35Phenylephrmne, effects of SKF 525A on responses

in aortic strips to, 500Phenyihydrazine, derivatives, structural require

ments for hemolysis iii amphibian red cells, 463Piocarpine, effect on cardiac sympathetic ganghia

of dog, 45 -Pine, G. L.

see Marchand, C., 232see Priestly, B. G., 221

Plasmaappearance or disappearance of norepinephrmne

in, 369levels of H-dihydromorphine, maternal and

fetaldistribution in tolerant and nontolerantrat, 9

Polydipsia, release of antidiuretic hormone and,interaction of central neurons with angiotensin, 27

Potassiumfluxes in frog sartorius muscle treated with

tetraalkylammonium ions, 141-induced contractions of aortic strips, selective

INDEX 577

blockade by @9-diethylaminoethyldiphenylpropylacetate (SKF 525A), 500

Practolol, beta adrenergic blocking agent, effect onpulmonary vessels, 487

Prat, J. C., see Kirpekar, S. M., 72Pregnancy, rat, tolerant and nontolerant, ma

ternal and fetal distribution of H@-dihydromorphine, 9

Priestly, B. G. and Plan, G. L. : Sulfobromophthalein metabolism and excretion in rats withiodomethane-induced depletion of hepaticglutathione, 221

Procaine, hydrolysis in fetal and newborn swine,185

Progesteroneanesthesia induced by, inhibition by steroids,

478testosterone and, hydroxylation by rat liver

microsomes, effect of morphine adininistration on, 211

Propionohydroxamate, excretion and metabolismin mice, 239

Propranolol -beta adrenergic blocking agent, effect on pul

monary vessels, 487ICI 50, 172 and, influence on cardiovascular

actions of catecholamines as modified byergotamine,315

Protein-synthesis inhibitors, nucleic acid- and, supres

sion of drug detoxication induced by spironolactone or ethylestrenol by, 473

synthesis, renal organic acid transport and,stimulation by penicillin, 152

Protryptaline, influence on effects of debrisoquin,bretylium and nialamide on adrenergic nervesas revealed by fluorescence histochemistry, 99

Putney, J. W., Jr., see Borzelleca, J. F., 527Pyridoxal phosphate co-factor, regulation of

hepatic tyrosine transaminase in vivo throughinteraction of norepinephrmne and, 283

Pyrogallol, effect on DMAE-induced potentiationof presser response to angiotensin and norepinephrmnein dogs, 36

Pyrolysis-gas chromatography- measurement of nanogram quantities of acetyl

choline by, demonstration in effluents fromrat phrenic nerve-diaphragm preparation, 337

measurement of -release of acetylcholine frominnervated and denervated rat diaphragm by,346

Rabbit(s)sciatic nerves of, absence of superaensitivity to

acetyicholine in innervated muscle subjectedto a@rolonged pharmacologic nerve block, 133

selective blockade of potassium-induced contractions of aortic strips by @-diethylamino

ethyldiphenylpropylacetate (SKF 525A) in,500

Rat(s)acetazolamide-treated, tissue acid-base balance

in, 535albino, iris of, effects of debnisoquin, bretylium

and nialamide on uptake, storage, metabolismand release of norepinephrine as revealed byfluorescence histochemistry in, 99

- augmentation of alkaloid formation from dopa

mine by alcohol and acetaldehyde in vitro in,401

brain cortex slices of, effect o ouabain on catecholamine biosynthesis in, 77

brain, efflux of chlorpromazine and tnifluoperazine from, 20

brain slices, human red cells and, active transport of Rb―in, 323

central effect of angiotensin in, release of pituitary pressor material, 27

changes in cation transport and (Na + K)-activated adenosine tniphosphatase producedby chronic administration of ethanol in, 330

differentiation of norepinephnine storage cornpartments in peripheral adrenergic nerves of,357

effect of 6-hydroxydopamine on brain norepinephrmne and dopamine, evidence for selectivedegeneration of catecholamine neurons in, 413

effect of SKF 525A on distribution of carbontetrachloride in, 232

effects of haloperidol and chiorpromazine onamphetamine metabolism and stereotype behavior in, 428

effects of hypoxia and hypercarbia on myocardial catecholamines in, 307

enzymatic basis of cyclophosphamide activationby hepatic microsomes of, 206

hepatic microsomes of, effect of morphine administration on hydroxylation of steroidhormones, 211

inhibition of anesthesia by steroids in, 478localization of depletion-sensitive and deple

tion-resistant norepinephrmne storage sites inautonomic ganglia of, 56

model of harmine metabolism in, 456natriuretic, - diuretic and anti-arginine-vaso

pressin (ADH) effects of two analogs of oxytocin in, 541

a new class of inhibitors of catechol-O-methyltransferase isolated from liver of, 83

phrenic nerve-diaphragm preparation, demonstration of acetylcholine in effluents from,measuring nanogram quantities by pyrolysisgas chromatography, 337

phrenic nerve-diaphragm preparation, isolated,faciitatory drug action on, 550

regulation of hepatic tyrosine transaminase in

578 INDEX

vivo through interaction of norepinephnineand pynidoxal phosphate co-factor, 283

release of acetylcholine from innervated anddenervated diaphragm of, 346

small intestine of, altered absorption of drugsby carbonic anhydrase inhibition from, 177

stimulation of renal organic acid transport andprotein synthesis by penicillin in, 152

studies indicating central antisecretory site ofaction for desmethylirnipramine (DM1) in, 421

supression by nucleic acid- and protein-synthesis inhibitors of drug detoxication induced byspironolactone or ethylestrenol in, 473

tetrahydropapaveroline, alkaloid metabolite ofdopamine in vitro, 388

tolerant and nontolerant, maternal and fetaldistribution of H@-dihydromorphine in, 9

vas deferens of, cellular studies of sympatheticdenervation produced by 6-hydroxydopaminein, 111

with iodomethane-induced depletion of hepaticglutathione, sulfobromophthalein metabolism and excretion in, 221

Rb―accumulation by rat brain cortex slices, effect

of administration of ethanol on, 330active transport in human red cells and rat brain

slices, 323Reserpine

blockade of DMAE-induced potentiation ofpressor response to angiotensin by, 35

effect on distribution of histamine in canineautonomic nervous system, 123

effect on intraneuronal and extraneuronalaccumulation of sympathomimetic amines inisolated nictitating membrane of cat, 290

a-methyl-m-tyrosine and, sensitivity or resistance of norepinephrmne storage sites in autonomic ganglia of rat to depletion by, 56

Respiratory tract, man, uptake of acetaldehyde in,14

Riboflavin, deficiencies, iron, iodide and, effectson hepatic drug-metabolizing enzyme eyetome, 197

Ridley, P. T., see Pendleton, R. G., 421Robert, E. D. and Oester, Y. T. : Absence of super

sensitivity to acetylcholine in innervatedmuscle subjected to a prolonged pharmacologic nerve block, 133

Rollings, D. E., Withrow, C. D. and Woodbury,D. M. : Tissue acid-base balance in acetazolamide-treated rats, 535

Rose, C., see Wurtman, R. J., 351Ryan, M. J. and Brody, M. J. : Distribution of

histamine in the canine autonomic nervoussystem, 123

Salicylate, model for movement across parotidepithelium, 527

C14-Salicylic acid, altered absorption from ratsmall intestine by carbonic anhydrase inhibition after pretreatment with acetazolamide,177

Sartorius musclefrog, site of action of lanthanum in, 517frog, treated with tetraalkiylammonium ions,

potassium fluxes in, 141Schaefer, see Van Orden, L. S., III, 357Schmidt, D. E., Szilagyi, P. I. A., Alkon, D. L. and

Green, J. P. : A method for measuring nanogram quantities of aeetylcholine by pyrolysisgas chromatography : The demonstration ofacetylcholine in effluents from the rat phrenicnerve-diaphragm preparation, 337

Schmidt, D. E., see Alkon, D. L., 346Schnell, R. C. and Miya, T. S. : Altered absorption

of drugs from the rat small intestine by carborne anhydrase inhibition, 177

Sciatic nerve, rabbits, subjected to prolongedpharmacologic block, absence of supersensitivity to acetyicholine in innervated muscle,133

Senoh, S., see Nikodejevic, B., 83Selye, H. : Inhibition of anesthesia by steroids, 478Serratus anterior, guinea pig, effect of curare-like

compounds on, 560Severs, W. B., Summy-Long, J., Taylor, J. S. and

Connor, J. D. : A central effect of angiotensin:Release of pituitary pressor material, 27

Short, C. R. and Davis, L. E. : Peninatal development of drug-metabolizing enzyme activity inswine, 185

Skeletal muscledog, peripheral vascular effects of cyclopropane

and halothane, 169innervated, subjected to prolonged pharmaco

logic nerve block, absence of supersensitivityto acetylcholine in, 133

SKF 525A(ft - diethylaminoethyldiphenylpropylacetate),

selective blockade of potassium-induced contractions of aortic strips by, 500

effect on distribution of carbon tetrachionide inrats, 232

Skin, dog, peripheral vascular effects of cyclopropane and halothane, 169

S1otk.in,@T. A. and DiStefano, V. : A model of harmine metabolism in the rat, 4.56

Smooth muscle, of vas deferens, examination aterinjection with 6-hydroxydopamine, 111

Solymoss, B., Krajny, M., Varga, S. and Werningloer, J. : Suppression by nucleic acid- andprotein-synthesis inhibitors of drug detoxication induced by spironolactone or ethylestrenol, 4732alazar, I., see Israel, Y., 330

579INDEX

Spano, P. F., Neff, N. H., Macko, E. and Costa,E. : Efflux of chlorpromazine and tnifluoperazino from the rat brain, 20

Spironolactoneethylestrenol or, supression by nucleic acid

and protein-synthesis inhibitors of drugdetoxication induced by, 473

inhibition of anesthesia induced by progesteroneor pentobarbital, 478

Spleens, cats, perfused, inhibitory effect of manganese on norepinephrmnerelease from, 72

Steroid hormones, hydroxylation of, by rat livermicrosomes, effect of morphine adininistration on, 211

Steroidseffect on cyclophosphamide-activating enzyme,

206inhibition of anesthesia by, 478

Storage sites, norepinephnine, depletion-sensitiveand depletion-resistant, in autonomic ganglia,localization of, 56

Streeter, C. L., seeFishbein, W. N., 239Succinylcholine

interactions with fadiitatory drugs in donorvated rat diaphragm, 550

responses oflidocaine-blocked muscles to, 133Sulfobromophthalein, metabolism and excretion

in rats with iodomethane-induced depletion ofhepatic glutathione, 221

Summy-Long, J., see Severs, W. B., 27Swine, perinatal development of drug-metaboliz

ing enzyme activity in, 185Sympathetic ganglia, cardiac, dog, effect of gan

glionic agonists and antagonists on, 45Sympathetic nervous system, cardiac, responses

to hypoxia and hypercarbia in rats, 307Sympathomimetic amines, in isolated nictitating

membrane of cat, intraneuronal and extraneuronal accumulation of, 290

Szilagri, P. I. A.see Alkon, D. L., 346see Schmidt, D. E., 337

Takahashi, A., see Kato, R., 211Taylor, J. S., see Severs, W. B., 27Tenen, S. S., see Koe, B. K., 434Testosterone, progesterone and, hydroxylation by

rat liver microsomes, effect of morphine administration on, 211

Tetraalkylammonium ions, potassium fluxes infrog sartorius muscle treated with, 141

Tetraethylammonium, effect on response to ganglionic agonists in dog, 45

Tetrahydro-4-aminoacridine, effects on phrenicnerve-diaphragm preparation of rat, 541

Tetrahydropapaverolinealkaloid motabolite of dopamine in vitro, 388

formation from dopamine, augmentation byalcohol and acetaldehyde in vitro, 401

Tetramethylammonium, effect on cardiac synipathetic ganglia of dog, 45

Tissueacid-base balance in acetazolamide-treated

rats, 535adipose, rat, effect of SKF 525A on distribution

of carbon tetrachloride in, 232levels of harmine metabolites in, 456

c-Toxiferine, effects in muscles of guinea pig, 560Traylor, T. D., see Breese, G. R., 413Trendolenburg, U., see Draskóczy, P. R., 290Trifluoperazine, chlorpromazine and, efflux from

rat brain, 20Trimethadione, pharmacologic interactions of

albutoin with, 276Truitt, E. B., Jr., seeKier, L B., 94Tubocuranine, effects in muscles of guinea pig, 560d-Tubocurarmne

effect on response to ganglionic agonists @ndog,45

responses of lidocaine-blocked muscles to, 133Turner, R. J., see Freeman, S. E., 550Tyramine, ability of DMAE and cocaine to alter

pressor response to, 35C―-Tyrosine, uptake and formation of C14-cate

cholamines from, in rat brain cortex slices,effect of ouabain on, 77

Tyrosine transaminase, hepatic, regulation invivo through interaction of norepinephrineand pyridoxal phosphate co-factor, 283

C14-Urea, altered absorption from rat small intestine by carbonic anhydrase inhibition afterpretreatment with acetazolarnide, 177

Urineappearance or disappearance of norepinephnine

in, 369, 381levels of harmine metabolites in, 456of mice, percent recovery of acetohydroxamate,

formohydroxamate, propionohydroxamateand isobutyrohydroxamate in, effect of barbital or 3-methyicholanthrene, 239

Van Orden, L. S., III, Burke, J. P., Geyer, M. andLodoen, F. V. : Localization of depletionsensitive and depletion-resistant norepinephrimestorage sites in autonomic ganglia, 56

Van Orden, L. S., III, Schaefer, J.-M., Burke, J.P. and Lodoen, F. V. : Differentiation ofnorepinephrmne storage compartments inperipheral adrenergic nerves, 357

Varga, S., see Solymoss, B., 473Vas deferens

mouse and rat, cellular studies of sympatheticdenervation produced by 6-hydroxydopaminein,111

580 INDEX

rat, disappearance of norepinephrmne as visualized by fluorescence histochemistry in, 357

Vasopressin, anti-arginine-, natriuretic, diureticand, effects of two analogs of oxytocin, 541

Veins, pulmonary, in intact dogs, effects of lidocaine, hexamethonium and alpha and betaadrenergic blocking agents on, 487

Vesicles, granular, norepinepbrine storage site inautonomic ganglia of rat, sensitive to depletion by reserpine anda-methyl-m-tyrosine, 56

du Vigneaud, V., see Chan, W. Y., 541Voile, R. L. : Potassium fluxes in frog sartonius

muscle treated with tetraalkylammonium ions,141

Wallin, R. F., Blackburn, W. H. and Napoli, M.D. : Pharmacologic interactions of albutoinwith other anticonvulsant drugs, 276

Walsh, M. J., Davis, V. E. and Yamanaka, Y.:Tetrahydropapaveroline: An alkaloid metab

, olite of dopamine in vitro, 388

Walsh, M. J., see Davis, V. E., 401

Weiss, G. B. : On the site of action of lanthanumin frog sartorius muscle, 517

Werningloer, J., see Solymoss, B., 473Withrow, C. D., see Rollins, D. E., 535Witt, E. D., see Lemberger, L., 428Woodbury, D. M., see Rollins, D. E., 535Woods, L. A., seeYeh, S. Y., 9Wurtman, R. J., Chou, C. and Rose, C. : The fate

of C14-dihydroxyphenylaianine (C14-dopa) inthe whole mouse, 351

Yaffe, S. J., see Cats, C. S., 197Yamanaka, Y.

seeDavis,V.E.,401 -see Walsh, M. J., 388

Yeh, S. Y. and Woods, L. A. : Maternal and fetaldistribution of H@-dihydromorphine in thetolerant and nontolerant rat, 9

Zoxasolamine, oxidation in fetal and newbornswine, 185