961

INDEX

Volume 239, October-December, 1986

A23187, analysis of airway responses (cats),395

Aarhus, L. L., see Zander, J. F., 760Abdel-Latif, A. A., see Howe, P. H., 574Abel, P. W. and Minneman, K. P.: Alpha-i

adrenergic receptor binding and con-traction of rat caudal artery, 678

Abou-Donia, M. B., see Patton, S. E., 597Acetaminophen

hepatoxicity, pre- or post-treatment withmethoxsalen (mice), 559

pharmacokinetics, prevention of inor-

ganic sulfate depletion (rats), 94Acetylcholine

excitatory amino acid receptors, folates,locomotor activity (rats), 627

releasecholecystokinin receptor mediation,

sphincter of Oddi (guinea pigs), 554muscarinic receptors, urinary bladder

(rats), 522

substance B isolation, presynapticmodulation (guinea pigs), 185

Acetylcholinesterase, inhibitor, clonidineprotection (mice), 43

N-Acetyltransferase, isoenzymes, identifi-

cation and inheritance, peripheralblood (hamsters), 823

a1-Acid glycoprotein, human serum albumin

and, interaction, lidocaine binding,754

Acoustic startle, dose-response analysis,

nicotine tolerance, receptor changes(mice), 358

Adenosine

renal transport, effects, papaverine and

theophylline (rats), 748

spinal, modulated antinociceptive path-ways, morphine stimulation (mice),88

Adenosine triphosphatase, digitalis me-chanical toxicity, protection by slowcalcium channel blockers (guineapigs), 206

Adenylate cyclaseage dependence, ureter homogenate

(guinea pigs), 99-y-aminobutyric acid B receptor-mediated

inhibition, cerebellar granule cells(rats), 568

Adipose tissue, 2,3,7,8-tetrachlorodibenzo-p-dioxin, mechanism of absorptionand distribution (rats), 673

Adler, B., see Yoburn, B. C., 132Adrenal gland, modulated catecholamine re-

lease, -y-aminobutyric acid (dogs),584

Adrenergic nerves, effects of naftidrofuryl,isolated blood vessels (dogs), 760

Adrenergic receptors, see AdrenoceptorsAdrenoceptors

alphaamiloride, myocardial and vascular ac-

tions (rats), 365

AY-28,925, in vitro characterization(rabbits, rats, dogs, guinea pigs), 1

nifedipine, vasoconstriction (dogs,

monkeys), 648

regulation of coronary artery bloodflow, normal and stenotic arteries(dogs), 641

sympathetic purinergic vasoconstric-tion, thermosensitivity in cutaneous

vein (dogs), 784alpha-i

anat.agonist, optical isomers of YM-12617 (rabbits), 512

antagonist effects, optical isomers ofYM-12617 (rabbits), 512

binding and contraction, caudal artery

(rats), 678

caffeine, discriminative stimulus prop-erties (rats), 706

alpha-2antagonist effects, fenoldopam (rab-

bits), 881

regulation ofsympathetic and parasym-pathetic nerves, salivary glands(rats), 488

alpha and betaablation of myenteric plexus, jejunal

longitudinal muscle (rats), 9estrogen modulation (guinea pigs), 270

betaagonists and antagonists, kinetic analy-

sis, 136AY-28,925, in vitro characterization

(rabbits, rats, dogs, guinea pigs), 1blocking agents, potentiation (rats),

797decreased responsiveness, aging (man),

802

dilevalol, cardiac electrophysiologicalactions (dogs), 719

down regulation in S49 lymphoma cells,atypical agonists, 654

effects of agonists and antagonists,ovarian suspensory ligament (rats),

591effects of pindolol and propanolol, lym-

phocytes, 117modulation, cytotoxic T cell generation

(mice), 460

uterine relaxation, cyclic AMP (rats),236

vascular smooth muscle relaxation, age-related decrease (rats), 411

beta-i, homogenous population, bovinecoronary artery, 634

low-affinity, prazosin, norepinephrinecontractions (rabbits), 846

Agbanyo, M., see Khatter, J. C., 206Aging

adenylate cyclase, ureter homogenate

(guinea pigs), 99decreased beta responsiveness (man), 802hypertension and, nitrovasodilators, en-

dothelial modulation of vascular

modulation (rats), 861vascular smooth muscle relaxation, beta

adrenergic receptor (rats), 411Agonists

alpha-i adrenoceptors, binding and con-

traction, caudal artery (rats), 678beta adrenoceptors

antagonists and, kinetic analysis, 136ovarian suspensory ligament (rats), 591

diazepam-agonist effects and, CGS 8216

(rats, mice), 166ethylketazocine and morphine, effects on

schedule-controlled behavior (pi-goons, monkeys), 433

regional characterization, depolarization-induced phosphoinositide hydrolysis,brain (rats), 873

Aguayo, L. G. and Albuquerque, E. X.:Blockade and recovery of the acetyl-choline receptor produced by athienyl analog of phencyclidine: In-fluence of voltage, temperature, fre-quency of stimulation and condition-

ing pulse duration, 25Aguayo, L. G. and Albuquerque, E. X.: Ef-

fects ofphencyclidine and its analogs

on the end-plate current of the neu-romuscular junction, 15

Aguayo, L. G., see Idniss, M. K., 279Airway

analysis of responses, A23187 (cats), 395histamine contraction, role of prostaglan-

dins (humans), 536vasoactive intestinal peptide receptors,

visualization, lung (humans, guineapigs), 249

Akhtar, R A., see Howe, P. H., 574Albumin, human serum, a,-acid glycopro-

tein and, interaction, 754

Albuquerque, E., see Idriss, M. K., 279Albuquerque, E. X., see Aguayo, L. G., 15,

25

Alcohol

dopamine release, preferential stimula-tion, nucleus accumbens (rats), 219

effects on LHRH-stimulated luteinizing

hormone, follicle-stimulating hor-

mone (monkeys), 693ethanol sensitivity and tolerance, WSP

and WSR mouse lines, 327Aiho, H., see Kataoka, Y., 584Aluminum chloride, ferric chloride or, effect

of lead uptake into brain and softtissues (rats), 548

Amiloride, myocardial and vascular actions,

SHR rats, 365-y-Aminobutyric acid

B receptor-mediated inhibition, adenylatecyclase, cerebellar granule cells(rats), 568

receptor modulation, catecholamine re-lease, adrenal gland (dogs), 584

5-Amino-2,4-dihydroxy-a-methylphenyl-ethylamine, neurochemical charac-

962 Index Vol. 239

terization, selective neurotoxin, cen-tral noradrenergic neuions (rats), 55

p-Aminohippurat.e, morphine tolerance,renal disposition, xenobiotics (mice),

346

Amino-pyridazine derivatives, evaluation,

conflict test (rats), 542Amiodarone, acute and chronic, cardiac

electrophysiologic effects, alteredthyroid hormone (rabbits), 179

Ammonium chloride, modification of behav-ioral effects, phencyclidine (rats), 48

Analgesiaadenosine-mediated, antinociceptive

pathways, morphine stimulation(mice), 88

intracerebroventricular injection of

TMB-8, antinociception production(mice), 320

Met-enkephalin release, �9-endorphin,stereoselective effect (rats), 160

opioid receptor upregulation, pharmaco-dynamic supersensitivity (mice), 132

Anaphylaxis, thromboxane and prostacyclinbiosynthesis, leukotriene D4, lung

(guinea pigs), 63Andresen, M. C., see Kunze, D. L., 303Angiotensin analogs, decapeptide, cardiac

and vascular actions (rabbits), 790Angiotensin II

atrial natnuretic peptide, interactions,sympathetic and endocrine systems

(rats), 480cyclic AMP concentrations, vascular

smooth muscle cells, endogenousprostaglandins (rats), 334

monoiodinated, full agonist analog ofangiotensin II, 71

Antagonists

beta adrenoceptorsagonists and, kinetic analysis, 136dilevalol, cardiac electrophysiological

actions (dogs), 719ovarian suspensory ligament (rats), 591

platelet activating factor receptor, L-652,731, profile (rats), 841

vasopressin receptor, analysis (humans),737

Anti-cholinesterase agents, glutamatergicsynapse, pre- and postjunctional ef-fects (locusts), 279

Anticonvulsant drugsbaclofen and phenobarbital, efficacy

against kainic acid limbic seizure-brain damage syndrome (rats), 612

effects on substantia nigra pars reticulataneurons, 606

temporal lobe epilepsy, quinoline acid(rats), 256

Anticonvulsant sensitivity, genetic differ-ences, selective breeding, ethanolwithdrawal severity (mice), 154

Antihypertensive agents, dilevalol, cardiac

electrophysiological actions (dogs),719

Antisuppressant drugs, histamine H1 antag-onists, behavioral effects (monkeys),104

Antiulcer agents, enprostil (rats), 382Anxiolytic drugs, amino-pyridazine deriva-

tives, evaluation, conflict test (rats),542

Aoki, K., see Asano, M., 198Aorta

extraneuronal serotonin uptake, mecha-nisms (rats), 264

norepinephrine contraction potentiation,

verapamil, diltiazem and nifedipine

(rabbits, swine), 808optical isomers of YM-12617, alpha-i ad-

renoceptor antagonist effects (rab-bits), 512

phorbol butyrate contractions, calcium

dependence, 8-Br-cyclic GMP, 78

role of vascular endothelium, contractileresponse, prostacyclin (rats), 390

Appel, N. M., see Kiritsy-Roy, J. A., 814Arachidonic acid

increased glomerular prostaglandin syn-

thesis, dexamethasone treatment(rats), 296

metabolites, leukotriene D4, lung (guineapigs), 63

AR-LiOO, cardiotonics, mechanism of ac-tion (cats), 375

Armstrong, D. R., see Ault, B., 612Aronstam, R. S., see Buccafusco, J. J., 43Asano, M., Aoki, K. and Matsuda, T.: Con-

tractile effects of bay k 8644, a dihy-dropyridine calcium agonist, on iso-lated femoral arteries from sponta-neously hypertensive rats, 198

Atrial natriuretic peptide, interactions,

sympathetic and endocrine systems(rats), 480

Atriopeptin, turnover, changes in plasmalevels and atrial content (rats), 474

Ault, B., Gruenthal, M., Armstrong, D. R.

and Nadler, J. V.: Efficacy of baclo-fen and phenobarbital against thekainic acid limbic seizure-brain dam-age syndrome, 612

Autonomic nerves, geographutoxin II, so-chum channel inhibitor (mice, bull-

frogs, guinea pigs, rabbits), 243Autoradiography, electron microscopic, cal-

cium redistribution, renal artery(rabbits), 286

AY-28,925, adrenoceptor activity, in vitrocharacterization (rabbits, rats, dogs,

guinea pigs), 1Ayad, M. J., see Hondeghem, L. M., 808

Baclofen, phenobarbital and, efficacyagainst kainic acid limbic seizure-brain damage syndrome (rats), 612

Baer, P. G., see Erman, A., 296Bains, R., see Khatter, J. C., 206Baker, K. M. and Khosla, M. C.: Cardiac

and vascular actions of decapeptideangiotensin analogs, 790

Baker, S., see Roszkowski, A. P., 382Balkovetz, D. F., see Ganapathy, V., 192Balster, R. L., see Beardsley, P. M., 311Banks, W. A. and Kastin, A. J.: Modulation

of the carrier-mediated transport ofthe Tyr-MIF-i across the blood-brain barrier by essential amino

acids, 668

Barbiturates, genetic differences, anticon-

vulsant sensitivity, ethanol with-drawal severity (mice), 154

Barnes, P. J., see Carstairs, J. R., 249Barrett, R. J. and Kau, S. T.: Myocardial

and vascular actions of amiloride inspontaneously hypertensive rats, 365

Bass, P., see Fox, D. A., 9Bay k 8644

contractile effects, femoral arteries, spon-

taneously hypertensive rats, 198

depolarization-induced phosphoinositide

hydrolysis, regional characterizationof agonist (rats), 873

Bayol, A., see Haye-Legrand, I., 536Beardsley, P. M., Balster, R. L. and Harris,

L. S.: Dependence on tetrahydrocan-nabinol in rhesus monkeys, 311

Behavioroperant, dependence of tetrahydrocanna-

binol (monkeys), 311schedule-controlled, effects of ethylketa-

zocine and morphine (pigeons, mon-keys), 433

tetrahydrocannabinol, sensory-evoked

potentials (rats), 936Belknap, J. K., see Crabbe, J. C., 154Benigni, A., see Perico, N., 229Benishin, C. G., Pearce, L. B. and Cooper,

J. R.: Isolation of a factor (substanceB) that antagonizes presynapticmodulation: Pharmaclogical proper-

ties, 185

Benveniste, J., see Haye-Legrand, I., 536Benzodiazepine

acute chlordiazepoxide dependence, phar-macologic characterization (rats),775

agonist and diazepam-agonist effects,CGS 8216 (rats, mice), 166

genetic differences, anticonvulsant sensi-

tivity, ethanol withdrawal severity(mice), 154

Benzodiazepine antagonists, amino-pyida-

zine derivatives, evaluation, conflict

test (rats), 542Bepridil, calcium entry blockade, vulnera-

bility toward ventricular fibrillation(dogs), 340

Bergman, J. and Spealman, R. D.: Somebehavioral effects of histamine H1antagonists in squirrel monkeys, 104

Berkowitz, B. A., see Ohlstein, E. H., 737Bevan, J. A., see Laher, I., 846Biftu,T.,seeWu,841

Bigelow, G. E., see Griffiths, R. R., 416Biliary excretion, organic anions, diabetes

(rats), 467Biziere, K., see Perio, A., 542Blair, D., see Matthews, R. T., 124Blaschke, T. F., see Pan, H. Y.-M., 802Blei, A., see Fung, H.-L., 701Blood, peripheral, N-acetyltransferase is-

oenzymes, identification and inher-itance (hamsters), 823

Blood-brain barrier, carrier-mediated trans-port of Tyr-MIF-i, essential aminoacids (mice), 668

Blood flownormal and stenotic coronary arteries, al-

pha adrenoceptor regulation (dogs),641

splanchnic, oral hydralazine and propran-

olol, interaction (dogs), 517Blood vessels

aging and hypertension, nitrovasodila-tom, endothelial modulation of vas-cular modulation (rats), 861

cutaneous, sympathetic purinergic vase-constriction, thermosensitivity

(dogs), 784low-affinity adrenoceptors, norepineph-

rime contractions (rabbits), 846vascular effects of naftidrofuryl (dogs),

760

BMY 14802, effects, brain dopaminergicfunction (rats), 124

Bobbitt, F. G., see Kiritsy-Roy, J. A., 814

1986 Index 963W

Bodd, E., Gadeholt, G., Christensson, P. I.and M#{248}rland,J.: Mechanisms behindthe inhibitory effect ofethanol on theconjugation of morphine in rat hep-atocytes, 887

Boisse, N. R., Periana, R. M., Guarino, J.

J., Kruger, H. S. and Samoriski, G.M.: Pharmacologic characterizationof acute chiordiazepoxide depend-ence in the rat, 775

Boldry, R., see Stephens, R. L., Jr., 627Boullet, C., see Haye-Legrand, I., 536Bowman, K. F., see Frazier, D. L., 946Bradbury, M W. B., see Deane, R., 548Bradycardia, amiloride, SHR rats, 365Brain

depolarization-induced phosphoinositidehydrolysis, regional characterizationof agonist (rats), 873

dopaminergic function, effects of BMY

14802 (rats), 124effect ofchronic cholinesterase inhibition,

phosphoinositide metabolism, car-bachol- and norepinephrine- stimu-lated (rats), 32

effects of mu-opioid receptor stimulation,

catecholamine secretion (rats), 814forskolin binding, guanylyl-5’-imidodi-

phosphate and sodium fluoride (rats),952

LY 165163, central serotonin agonist ac-tions (rats), 454

membranes, binding of fl-funaltrexamine,opioid receptors (guinea pigs), 351

salivary gland and, bupivacaine transport(rats), 724

soft tissues and, lead uptake, effects ofintravenous ferric or aluminum chlo-ride (rats), 548

soman to�icity, clonidine protection(mice), 43

spinal cord and, tri-O-cresyl-induced de-layed neurotoxicity, enhanced phos-phorylation (hens), 597

substance B isolation, presynaptic modu-lation (guinea pigs), 185

Bree, M. P., see Mello, N. K., 693Brink, C., see Haye-Legrand, I., 536O-4-Bromo-2,5-dichlorophenyl, tri-O.cresyl

phosphate-induced delayed neuro-toxicity, enhanced phosphorylation,brain and spinal cord proteins (hens),

597

a-Bromoisovalerylurea, glutathione conju-

gation, 898, 905Brush-border, placental sodium-hydrogen

exchanger, inhibition by cimetidine,

192

Brussee, J., see te Koppele, J. M., 898Buccafusco, J. J. and Aronstam, R. S.: Clon-

idine protection from the toxicity of

soman, an organophophate acetyl-cholinesterase inhibitor, in themouse, 43

Buja, L. M., see Wheeler-Clark, E. S., 286Bupivacaine, plasma protein binding, trans-

port into brain and salivary gland(rats), 724

Byrne, A. J., see Corbett, H., 517

Caffeinechronically consumed, elimination, preg-

nancy (monkeys), 891discriminative stimulus properties, nor-

adrenergic mediation (rats), 706

human coffee drinking, reinforcing andphysical dependence producing ef-fects, 416

Cahill, C. M., see Corbett, H., 517Calassi, R., see Perio, A., 542Calcium

antagonistscalcium channel action, baroreceptor

function (rats), 303TMB-8 injection, antinociception pro-

duction (mice), 320effect of carbachol, myosin light chain

phosphorylation, contraction of irissphincter muscle (rabbits), 574

entry blockers, vulnerability toward yen-tricular fibrillation (dogs), 340

phorbol butyrate contractions, 8-Br-cyclic GMP, 78

redistribution, electron microscopic au-toradiography, renal artery (rabbits),286

Calcium channel

Bay k 8644 contractile effects, femoralarteries, SHR rats, 198

blockers, digitalis mechanical toxicityprotection (guinea pigs), 206

calcium antagonists, baroreceptor func-tion (rats), 303

1,4-dihydropyridine activator-antagonistpairs, smooth muscle (rats, guinea

pigs), 144dihydropyridine binding to receptors, ef-

fect of diltiazem, magnesium influ-ence (chicks), 768

norepinephrine contraction potentiation,verapamil, diltiazem and nifedipine(rabbits, swine), 808

ouabain and canrenone, macrophages,

vascular smooth muscle cells (mice),

867Calcium disodium ethylenediamine tetraa-

cetate, treatment of lead-poisoned

children, lead, zinc and copper decor-poration, 829

Campbell, B. S., see Lakshmanan, M. R.,673

Campbell, K. A., Foster, T. C., Hampson, R.E. and Deadwyler, S. A.: Effects of�#{176}-tetrahydrocannabinol on sensory-evoked discharges of granule cells in

the dentate gyms of behaving rats,941

Campbell, K. A., Foster, T. C., Hampson, R.E. and Deadwyler, S. A.: �9-Tetra-hydrocannabinol differentially af-fects sensory-evoked potentials in the

rat dentate gyms, 936Canrenone, effect on cation handling, oua-

bain, macrophages and vascular

smooth muscle cells (mice), 867Carbachol

effect on myosin light chain phosphor-ylation, contraction, iris sphinctermuscle (rabbits), 574

phosphoinositide metabolism, effect ofchronic cholinesterase inhibition,brain (rats), 32

Carbamate, organophosphates and, pre- andpostjunctional effects, glutamatergicsynapse (locusts), 279

Cardiac electrophysiology, acute and

chronic amiodarone, effects, alteredthyroid hormone (rabbits), 179

Cardiac output, determinant, nitroglycerinpharmacokinetics (rats), 701

Cardiotonics, AR-L100, mechanism of ac-

tion (cats), 375Cardiovascular system

actions, decapeptide angiotensin analogs(rabbits), 790

desensitization, responses of histamine

(rats),730effects of mu-opioid receptor stimulation,

brain, catecholamine secretion (rats),

814

Carstairs, J. R. and Barnes, P. J.: Visuali-zation of vasoactive intestinal pep-tide receptors in human and guineapig lung, 249

Carter, H., see Roszkowski, A. P., 382Catalepsy, effects of BMY 14802, brain do-

paminergic function (rats), 124Catecholamines, modulated release, ‘y-ami-

nobutyric acid, adrenal gland (dogs),584

Caudal artery, alpha-i adrenoceptors, bind-ing and contraction (rats), 678

Celiprolol, beta adrenoceptors, down regu-lation, 549 lymphoma cells, 654

Central nervous system

carrier-mediated transport of Tyr-MIF-1,blood-brain barrier, essential aminoacids (mice), 668

Met6-enkephalin-Ar�-Phe7 degradation,

inhibition, dipeptidyl carboxypeptid-ase inhibitors (rats), 174

Cerebellar granule cells, inhibited adenylate

cyclase, GABAB, blockade by islet-activating protein (rats), 568

Cerrina, J., see Haye-Legrand, I., 536CGS 8216, agonist and diazepam-agonist

effects (rats, mice), 166Chambon, J.-P., see Perio, A., 542Chang, H., see Hoffman, B. B., 715Chan, W. C., see Glass, J., 742Chan, W. Y., Hruby, V. J., Rockway, T. W.

and Hiavacek, J.: Design of oxytocinantagonists with prolonged action:

Potential tocolytic agents for the

treatment of preterm labor, 84Chen, Y.-F., see Nagahama, S., 426Chiari, M. C., see D’Agostino, G., 522Chirtel, S. J., see Lakshmanan, M. R., 673Chisoim, J. J., Jr., see Thomas, D. J., 829Chiu, P. J. S., see Sybertz, E. J., 78Chlordiazepoxide, acute dependence, phar-

macologic characterization (rats),775

CholecystokininCCK-related peptides and, neurons in in-

ferior mesenteric ganglion (guineapigs), 618

receptor mediation, acetylcholine release,sphincter of Oddi (guinea pigs), 554

Cholinesterase, effect of chronic inhibition,phosphoinositide metabolism, car-bachol- and norepinephrine-stimu-lated (rats), 32

Chong, S., see Fung, H.-L., 701Choroid plexus, cimetidine transport (rats),

927

Cho, Y. H., see Wheeler, M. A., 99Christensen, H., see Christensen, S., 211Christensen, S., Steiness, E. and Christen-

sen, H: Tubular sites of furosemidenatriuresis in volume-replaced andvolume-depleted consious rats, 211

Christensson, P. I., see Bodd, E., 887Cimetidine

inhibition, placental sodium-hydrogen ex-

changer, 192transport, choroid plexus (rats), 927

964 Index Vol. 239

Clark, M. A., see Mong, S., 63Cline, W. H., Jr., see Shirasaki, Y., 861Clonidine

ablation of myenteric plexus, alpha adre-nergic response, jejunal longitudinalmuscle (rats), 9

dopamine1 receptor agonist, a4,ha-2 ad-renoceptor antagonist, effects of fen-oldopam (rabbits), 881

protection from soman toxicity (mice), 43Codeine, dextromethorphan effect on ileal

contractility, compared with levome-thorphan and loperamide (guineapigs), 627

Coffee, drinking, reinforcing and physical

dependence producing effects, 416

Collins, A. C., see Marks, M. J., 358Collins, A. C., see Miner, L. L., 853Constantine, J. W., see Woodman, 0. L.,

648Contreras, M. L., Wolfe, B. B. and Molinoff,

P. B.: Kinetic analysis of the inter-actions of agonists and antagonistswith beta adrenergic receptors, 136

Cooper, J. R., see Benishin, C. G., 185Copper, lead and zinc decorporation, treat-

ment of lead-poisoned children, 829Corbett, H., Cahill, C. M., Heinzow, B.,

Harrison, P. M., Byrne, A. J. andMcLean, A. J.: Interaction betweenoral hydralazine and propranolol. II.Assessment of altered splanchnicblood flow as the determinant of al-tered presystemic extraction, 517

Coronary arteryblood flow, alpha adrenoceptor regulation,

normal and stenotic arteries (dogs),641

bovine anterior descending, beta-i adre-noceptors, homogenous population,

634histamine-induced relaxation, mecha-

nisms (monkeys, dogs), 529norepinephrine contraction potentiation,

verapamil, diltiazem and nifedipine

(rabbits, swine), 808phorbol diesters, after contractile re-

sponses (swine), 38

Corticosterone, LY 165163, central sero-tonin agonist actions (rats), 454

Costa, E., see Mellstrom, B., 174Costa, L. G., Kaylor, G. and Murphy, S. D.:

Carbachol- and norepinephrine-stimulated phosphoinositide metab-olism in rat brain: Effect of chroniccholinesterase inhibition, 32

Coulson, R. and Trimble, M. E.: Effects of

papaverine and theophylline on renal

adenosine transport, 748

Crabbe, J. C. and Kosobud, A.: Sensitivityand tolerance to ethanol in mice bredto be genetically prone or resistant to

ethanol withdrawal seizures, 327Crabbe, J. C., Young, E. R., Tam, B., Ko-

sobud, A., Belknap, J. K. and Laur-sen, S. E.: Genetics differences inanticonvulsant sensitivity in mouse

lines selectively bred for ethanolwithdrawal severity, 154

Crews, F. T., see Gonzales, R. A., liiCrooke, S. T., see Mong, S., 63Cyclic AMP

inhibited adenylate cyclase, GABAB, cer-

ebellar granule cells (rats), 568prostaglandin E1 receptor-mediated re-

sponse, effects of chronic ethanol ex-posure, neuroblastoma clone (mice),687

uterine relaxation, isoproterenol and for-skolin, differential effect (rats), 236

vascular smooth muscle relaxationage-related decrease, beta adrenergic re-

ceptors (rats), 411vasoactive peptide hormones, endoge-

nous prostaglandins (rats), 334Cyclic GMP, phorbol dibutyrate contrac-

tions, aorta, calcium dependence, 78

Cycbooxygenase

A23i87, analysis of airway responses

(cats), 395leukotriene D4, arachidonic acid metabo-

lites (guinea pigs), 63

Cyclopentenone, prostaglandins, site andmechanism of growth inhibition, 500

Cyclosporine, effect of short-term adminis-tration, renin-angiotensin and

thromboxane A2, glomerular filtra-tion rate (rats), 229

Cytotoxic T lymphocytes, generation, mod-ulation by beta adrenoceptors (mice),460

D’Agostino, G., Kilbinger, H., Chiari, M. C.and Grana, E.: Presynaptic inhibi-tory muscarinic receptors modulating[3HJ acetylcholine release in the rat

urinary bladder, 522Dall’aglio, E., see Hoffman, B. B., 715Dar, M. S., see Garris, D. R., 270Deadwyler, S. A., see Campbell, K. A., 936,

941Deane, R., Park, S. H. and Bradbury, M. W.

B.: Effect of intravenous ferric or alu-minum chloride on the uptake of�#{176}�Pbinto brain and other soft tissuesof rats, 548

DeGott, C., see Letteron, P., 559DeLander, G. E. and Hopkins, C. J.: Spinal

adenosine modulates descending an-tinociceptive pathways stimulated bymorphine, 88

Denson, D. D., see Terasaki, T., 724Dentate gyros

tetrahydrocannabinolsensory-evoked discharges, granule

cells (rats), 941

sensory-evoked potentials (rats), 936Descatoire, V., see Letteron, P., 559Desiderio, D. M., see Sybertz, E. J., 78Devoe, L. D., see Ganapathy, V., 192Dewey, W. L., see Welch, S. P., 320Dexamethasone, treatment, increased gb-

merubar prostaglandin synthesis(rats), 296

Dextromethorphan, effect on ileal contrac-tility, compared with levomethor-

phan, boperamide and codeine(guinea pigs), 627

Diabetes, biliary excretion, organic anions

(rats), 4671,2-Diacylglycerol, effect of carbachol, con-

traction, iris sphincter muscle (rab-bits), 574

Diastereomers, glutathione conjugation, a-bromoisovalerylurea as model sub-

strate, 898, 905

Diazepam, agonist effects, CGS 8216 (rats,mice), 166

Di Chiara, G., see Imperato, A., 219

8-(N,N-Diethylamino)octyl-3,4,5,-trime-thoxybenzoate, see TMB-8

Digitalis, mechanical toxicity, protection byslow calcium channel blockers(guinea pigs), 206

DihydropyridineBay k 8644 contractile effects, femoral

arteries, SHR rats, 198increased binding, magnesium, effect of

diltiazem (chicks), 768Dilevalol, cardiac electrophysiologic actions

(dogs), 719Diltiazem

action on calcium channels, baroreceptorfunction (rats), 303

calcium entry blockade, vulnerability to-ward ventricular fibrillation (dogs),340

influence of magnesium, increased dihy-dropyridine binding, cardiac and

skeletal muscle membranes (chicks),768

verapamil and nifedipine, norepinephrinecontractions, potentiation (rabbits,swine), 808

DiMicco, J. A., see Hatfield, S. M., 460Dipeptidyl carboxypeptidase, inhibitors, in-

hibition of Met5-enkephalin-Ar�-

Phe7 degradation (rats), 174Dix, L. P., see Frazier, D. L., 946Doebber, T. W., see Wu, 841Dogterom, P., see te Koppele, J. M., 905Dopamine

5-amino-2,4-dihydroxy-a-methylphenyl-ethylamine, neurochemical charac-

terization, central noradrenergic neu-rons (rats), 55

LY 165163, central serotonin agonist ac-tions (rats), 454

LY171555, mechanism of depressor ac-

tion (rats), 426modulated release, D-2 dopamine recep-

tors, striatal slices (rats), 442preferential stimulation, nucleus accum-

bens, ethanol (rats), 219receptor agonist, fenoldopam effects (rab-

bits), 881

Dorsal caudate, dopamine release, prefer-ential stimulation, ethanol (rats), 219

Drug dependence, human coffee drinking,

caffeine, 416Drug interaction, oral hydralazine and pro-

pranobol (dogs), 517Dungan, K. W., see Stanton, H. C., 591Dwoskin, L. P. and Zahniser, N. R.: Robust

modulation of [3Hjdopamine releasefrom rat striatal slices by D-2 dopa-mine receptors, 442

Eckfeldt, J. H., see Krauss, E., 754Eicosatetraynoic acid, endothelial potentia-

tion of relaxation response, beta ad-renoceptor blocking agent (rats), 797

Ekarohita, N., see Lakshmanan, M. R., 673Elverdin, J. C., see Kaniucki, M. D., 488Endocrine system, sympathetic nervous sys-

tem and, interactions, atrial natri-uretic peptide (rats), 480

13-Endorphin, stereoselective effect, analge-sia production, Met-enkephalin re-lease (rats), 160

Endothelium

effects ofnaftidrofuryl, isolated blood yes-

sels (dogs), 760

1986 Index 965

modulation of vascular relaxation, nitro-vasodilators, aging and hypertension

(rats), 861potentiation of relaxation response, beta

adrenoceptor blocking agents (rats),

797vascular, contractile response in aorta,

prostacyclin (rats), 390Endothelium-derived relaxing factor, hista-

mine, mechanisms of relaxation, cor-onary arteries (monkeys, dogs), 529

End-plate currentneuromuscular junction, effects of phen-

cycbidine and analogs (frogs), 15thienyl analog of phencyclidine, acetyb-

choline receptor, blockade and recov-ery (frogs), 25

Enboe, L., see Richelson, E., 687Enprostil, gastric antisecretory and antiul-

cer properties (rats), 382Epilepsy

kainic acid limbic seizure-brain damagesyndrome, efficacy of bacbofen and

phenobarbital (rats), 612

temporal lobe, anticonvulsant drugs,

quinoline acid (rats), 256

Epinephrinebeta adrenoceptors, modulation, cytotoxic

T cell generation (mice), 460LY171555, mechanism of depressor ac-

tion (rats), 426EPSP, glutamatergic synapse, pre- and

postjunctional effects, organophos-

phates and carbamate compounds(locusts), 279

Erman, A., Hassid, A., Baer, P. G. andNasjletti, A.: Treatment with dexa-methasone increases gbomerular

prostaglandin synthesis in rats, 296Estrogen, , preferential stimulation, nucleus

accumbens (rats), 219effects of chronic exposure, prostaglandin

E1, neuroblastoma clone (mice), 687mechanisms behind inhibitory effect,

conjugation of morphine, hepato-cytes (rats), 887

membrane actions, inhibited histaminerelease, mast cells (rats), lii

sensitivity and tolerance, WSP and WSR

mouse lines, 327withdrawal severity, genetic differences,

anticonvulsant sensitivity (mice),154

Ethylketazocine, morphine and, effects onschedule-controlled behavior (pi-geons, monkeys), 433

Evans, D. C., see Lin, T.-M., 400, 406Ezekiel, M., see Lakshmanan, M. R., 673

Fatty acids, free, suppression by phenyliso-propyladenosine (rats), 715

Femoral artery, Bay k 8644 contractile ef-fects, SHR rats, 198

Fenoldopam, alpha-2 adrenoceptor antago-nist effects, dopamine1 receptor ago-nist and (rabbits), 881

Fenoterol, bovine anterior descending coro-nary artery, beta-i adrenoceptors, ho-mogenous population, 634

Ferguson, R. J., see Hem, D. W., 823Ferric chloride, aluminum chloride or, effect

of lead uptake into brain and softtissues (rats), 548

Fetus, chronically consumed caffeine, elim-ination, pregnancy (monkeys), 891

Flavahan, N. A. and Vanhoutte, P. M.: Sym-pathetic purinergic vasoconstrictionand thermosensitivity in a canine cu-taneous vein, 784

Folici acid, activation of excitatory amino

acid receptors, locomotor activity,nucleus accumbens (rats), 627

Follicle-stimulating hormone, LHRH-stim-ulated luteinizing hormone, alcoholeffects (monkeys), 693

5-Formyltetrahydrofolic acid, activation ofexcitatory amino acid receptors, bo-

comotor activity, nucleus accumbens(rats), 627

Forray, C., see Richelson, E., 687Forskolin

binding, guanylyl-5’-imidodiphosphate

and sodium fluoride (rats), 952isoproterenol and, uterine relaxation,

cyclic AMP (rats), 236vascular smooth muscle relaxation, age-

related decrease, beta adrenoceptors(rats), 411

Foster, T. C., see Campbell, K. A., 936, 941Fox, D. A. and Bass, P.: Ablation of the

myenteric plexus impairs alpha butnot beta adrenergic receptor-me-diated mechanical responses of ratjejunal longitudinal muscle, 9

Frazier, D. L., Dix, L. P., Bowman, K. F.,Thompson, C. and Riviere, J. E.: In-creased gentamicin nephrotoxicity innormal and diseased dogs adminis-tered identical serum drug concentra-tion profiles: Increased sensitivity insubclinical renal dysfunction, 946

Fujimoto, M., see Kataoka, Y., 584Fujiwara, M., see Narumiya, S., 506Fujiwara, M., see Ueda, N., 494Fukuda, S., Su, C. and Lee, T. J.-F.: Mech-

anisms of extraneuronal serotonin

uptake in the rat aorta, 264Fukushima, M., see Narumiya, S., 500, 506Fuller, R. W., Snoddy, H. D. and Molloy, B.

B.: Central serotonin agonist actionsof LY 165163, 1-(m-trifluoromethyl-phenyl)-4-(p-aminophenylethyl) pi-

perazine, in rats, 454fl-Funaltrexamine, binding to opioid recep-

tors, brain membranes (guinea pigs),

351

Fung, H.-L., Blei, A. and Chong, S.: Cardiac

output is an apparent determinant ofnitroglycerin pharmacokinetics inrats, 701

Furosemide, natriuresis, tubular sites (rats),211

Furukawa, T., see Harad.a, T., 554

Gadeholt, G., see Bodd, E., 887Gaginella, T. S., see Kachur, J. F., 627Ganapathy, M. E., see Ganapathy, V., 192Ganapathy, V., Balkovetz, D. F., Miyamoto,

Y., Ganapathy, M. E., Mahesh, V. B.,Devoe, L. D. and Leibach, F. H.: In-hibition of human placental Na�-H�

exchanger by cimetidine, 192Ganglion, inferior mesenteric, action of cho-

lecystokinin octapeptide and CCK-related peptides (guinea pigs), 618

Garay, G. L., see Roszkowski, A. P., 382Garay, R., see Hannaert, P., 867Garris, D. R., McConnaughey, M. M. and

Dar, M. S.: Estrogen modulation ofuterine adrenergic-cholinergic inter-

action: Effects on vasoactivity andadrenergic receptors in the guineapig, 270

Garty, M. and Hurwitz, A.: Tolerance tomorphine effects on renal dispositionof xenobiotics in mice, 346

Gastric acidnizatidine actions (dogs, rats, frogs), 406nizatidine actions (rats, dogs), 400

Gastric antisecretory action, antiulcer prop-erties and, enprostil (rats), 382

Geffard, M., see Kataoka, Y., 584Gehlert, D. R.: Regional modulation of

[3Hjforskolin binding in the rat brainby guanylyl-5’-imidodiphosphate andsodium fluoride: Comparison withthe distribution of guanine nucleo-tide binding sites, 952

Geneticsanalysis of nicotine-induced seizures,

nicotinic receptors (mice), 853differences, anticonvulsant sensitivity,

ethanol withdrawal (mice), 154nicotine tolerance, dose-response analy-

sis, receptor changes (mice), 358

Geneve, J., see Letteron, P., 559Gentamicin, nephrotoxicity (dogs), 946Geoffroy, S., see Gilbert, S. G., 891Geographutoxin II, sodium channel inhibi-

tor, skeletal muscles, autonomic

nerves (mice, bullfrogs, guinea pigs,rabbits), 243

Gerber, J. G., see Hedberg, A., 117Gertner, S. B., see Poulakos, J. J., 730Ghilardi, F., see Perico, N., 229Gilbert, S. G., So, Y., Klassen, R. D., Goof-

froy, S., Stavric, B. and Rice, D. C.:Elimination of chronically consumedcaffeine in the pregnant monkey (ma-coca fascicularis), 891

Gillespie, M. N., Kojima, S., Kunitomo, M.and Jay, M.: Coronary and myocar-dial effects of activated neutrophilsin perfused rabbit hearts, 836

Gintzler, A. R., see Glass, J., 742Glass, J., Chan, W. C. and Gintzber, A. R.:

Direct analysis of the release of me-thionine-enkephalin from guinea pigmyenteric plexus: Modulation by en-dogenous opioids and exogenousmorphine, 742

Gleason, J. G., see Mong, S., 63Gbomerular filtration rate, short-term cycbo-

sporine administration, renin-angio-tensin and thromboxane A2 (rats),

229Glutamatergic synapse, pre-and postjunc-

tional effects, organophosphates andcarbamate compounds (locusts), 279

Glutathione, conjugation, a-bromoisovaler-

ylurea, 898, 905Goldberg, S. R., see Katz, J. L., 433Gonzales, R. A. and Crews, F. T.: Correla-

tion of ethanol’s membrane actionsand inhibition of receptor-stimulatedhistamine release from rat mast cells,111

Grana, E., see D’Agostino, G., 522Granule cells, dentate gyros, sensory-evoked

discharges, tetrahydrocannabinol(rats), 941

Griffiths, R. R., Bigebow, G. E. and Liebson,

I. A.: Human coffee drinking. Rein-forcing and physical dependence pro-ducing effects of caffeine, 416

966 Index

Grimes, D., see Rimele, T. J., 1Gruenthal, M., see Ault, B., 612Gualandris, L., see Perico, N., 229Guanylyl-5’-imidodiphosphate, sodium flu-

oride and, forskolin binding (rats),952

Guarino, J. J., see Boisse, N. R., 775Guidotti, A., see Kataoka, Y., 584Gunnes, P., Reiker#{224}s,0. and Lygren, I.:

Secretion infusion in acute ischemicleft ventricular failure: Effects onmyocardial performance and metab-

olism in a closed-chest dog model, 915

Haass, M., see Zukowska-Grojec, Z., 480Halsall, H. B., see Krauss, E., 754Hampson, R. E., see Campbell, K. A., 936,

941Hanano, M., see Suzuki, H., 927Hanbauer, I., see Kataoka, Y., 584Hannaert, P., Thormann, B. and Garay, R.:

Effect of canrenone on the disturb-ances of cation handling induced byouabain in macrophages and vascularsmooth muscle cells, 867

Harada, T., Katsuragi, T. and Furukawa,T.: Release of acetylcholine mediatedby cholecystokinin receptor from theguinea pig sphincter of Oddi, 554

Harbon, S., see Khac, L. D., 236Harris, L. S., see Beardsley, P. M., 311Harrison, P. M., see Corbett, H., 517Hassid, A.: Increase of cyclic AMP concen-

trations in cultured vascular smoothmuscle cells by vasoactive peptidehormones. Role of endogenous pros-taglandins, 334

Hassid, A., see Erman, A., 296Hatfield, S. M., Petersen, B. H. and Di-

Micco, J. A.: Beta adrenoceptor mod-ulation of the generation of murinecytotoxic T lymphocytes in vitro, 460

Hawkins, D. J., see Miller, J. R., 38Haye-Legrand, I., Cerrina, J., Raffestin, B.,

Labat, C., Boullet, C., Bayol, A., Ben-veniste, J. and Brink, C.: Histaminecontraction of isolated human airwaymuscle preparations: Role of prosta-glandins, 536

Hayes, J. S., Wyss, V. L., Wilson, H. C.,Robertson, D. W. and Kauffman, R.F.: Molecular basis for the in vitroand in vivo cardiotonic activities ofAR-L100, 375

Heart

acute failure, secretin infusion (dogs), 915beta adrenoceptors, effects ofpindobol and

propranobol, lymphocytes, 117

digitalis mechanical toxicity, protectionby slow calcium channel blockers(guinea pigs), 206

effects of activated neutrophils (rabbits),836

electrophysiobogical actions

acute and chronic amiodarone, alteredthyroid hormone (rabbits), 179

SCH 19927 (dogs), 719Heart rate, dose-response analysis, nicotine

tolerance, receptor changes (mice),

358Heaslip, R. J., see Rimele, T. J., 1Heaulme, M., see Perio, A., 542Hedberg, A., Gerber, J. G., Nies, A. S.,

Wolfe, B. B. and Molinoff, P. B.:Effects of pindobol and propranobol

on beta adrenergic receptors on hu-man lymphocytes, 117

Hedler, L., see Szabo, B., 881Hem, D. W., Kirlin, W. G., Ferguson, R. J.,

Thompson, L. K. and Ogolla, F.:Identification and inheritance ofinbred hamster N-acetyltransferaseisozymes in peripheral blood, 823

Heinzow, B., see Corbett, H., 517Hepatic clearance, oral hydralazine and pro-

pranolol (dogs), 517Hepatocytes, conjugation of morphine,

inhibitory effect of ethanol, mecha-nisms (rats), 887

Hepatoxicity, acetaminophen, pre- or post-treatment with methoxsalen (mice),559

Hippocampus

anticonvulsant drugs, temporal lobe epi-lepsy, quinoline acid (rats), 256

efficacy of baclofen and phenobarbital,kainic acid limbic seizure-brain dam-age syndrome (rats), 612

nicotine-induced seizures, nicotinic re-ceptors, genetic analysis (mice), 853

Histamineairway muscle contraction, role of pros-

taglandins (humans), 536central cardiovascular responses, desen-

sitization (rats), 730

H1-receptor antagonist, behavioral effects(monkeys), 104

H2-receptor antagonistnizatidine actions, gastric acid secre-

tion (dogs, rats, frogs), 406nizatidine actions on uterus and stom-

ach (rats, dogs), 400induced relaxation, mechanisms, coro-

nary arteries (monkeys, dogs), 529receptor-stimulated release, ethanol’s

membrane actions, mast cells (rats),111

Hlavacek, J., see Chan, W. Y., 84Hoeschen, R. J., see Khatter, J. C., 206Hoffman, B. B., Dall’aglio, B., Hollenbeck,

C., Chang, H. and Reaven, G. M.:Suppression of free fatty acids andtriglycerides in normal and hypertri-glyceridemic rats by the adenosinereceptor agonist phenylisopropylad-

enosine, 715Hoffman, B. B., see Pan, H. Y.-M., 802Hoffman, B. B., see Tsujimoto, G., 411Hollenbeck, C., see Hoffman, B. B., 715Holtzman, J. L., see Krause, E., 754Holtzman, S. G.: Discriminative stimulus

properties of caffeine in the rat: Nor-adrenergic mediation, 706

Honda, K. and Nakagawa, C.: Alpha-i ad-renoceptor antagonist effects of theoptical isomers of YM-i26i7 in rab-bit lower urinary tract and prostate,512

Hondeghem, L. M., Ayad, M. J. and Rob-

ertson, R. M.: Verapamil, diltiazemand nifedipine block the depolariza-tion-induced potentiation of norepi-nephrine contractions in rabbit aortaand porcine coronary arteries, 808

Hopkins, C. J., see DeLander, G. B., 88Hosey, M. M., see Maan, A. C., 768Housman, A., see Wheeler, M. A., 99Howe, P. H., Akhtar, R A., Naderi, S. and

Abdel-Latif, A. A.: Correlative stud-ies on the effect of carbachol on myo-

Vol. 239

inositol trisphosphate accumulation,myosin bight chain phosphorybationand contraction in sphincter smoothmuscle of rabbit iris, 574

Hruby, V. J., see Chan, W. Y., 84Hurwitz, A., see Garty, M., 346Husain, A., Pajka, S. F., Taylor, S. M. and

Speth, R. C.: Monoiodinated angio-tensin II is a potent, full agonist an-

abog of angiotensin II, 71Hydralazine, oral, propranobol and, inter-

action (dogs), 517Hydrocortisone, plasma, prednisobone con-

centration-effect relations (man),919

5-Hydroxytryptamine, see SerotoninHyman, A. L., see Kriseman, T., 395Hypertension

aging and, nitrovasodilators, endothelialmodulation of vascular modulation(rats), 861

Bay k 8644 contractile effects, femoralarteries, SHR rats, 198

Hypotension, amiboride, myocardial andvascular actions, SHR rats, 365

Hypothalamic nuclei, 5-amino-2,4-dihy-droxy-a-methylphenylethylamine,neurochemical characterization, cen-tral noradrenergic neurons (rats), 55

Hypothermia, ethanol sensitivity and tol-erance, WSP and WSR mouse lines,

327

Iadarola, M. J., see Melbstrom, B., 174Idriss, M. K., Aguayo, L. G., Rickett, D. L.

and Albuquerque, E. X.: Organophos-phate and carbamate compoundshave pre- and postjunctional effectsat the insect glutamatergic synapse,

279

Iga, T., see Suzuki, H., 927Ileum

effect on contractility, dextromethorphan(guinea pigs), 627

release of methionine-enkephalin, endog-enous opioids and exogenous mor-

phine (guinea pigs), 742Immunoregulation, beta adrenoceptors,

modulation, cytotoxic T cell genera-tion (mice), 460

Immunosuppression, prednisobone concen-tration-effect relations, influence ofplasma hydrocortisone (humans),

919Imperato, A. and Di Chiara, G.: Preferential

stimulation of dopamine release in

the nucleus accumbens of freely mov-ing rats by ethanol, 219

Impromidine, central cardiovascular re-sponses, histamine, desensitization(rats), 730

Indocyanine, biliary excretion, organic an-ions, diabetes (rats), 467

Indomethacin, histamine contraction, air-way muscle, role of prostaglandins(humans), 536

Inorganic sulfate, depletion prevention, ac-etaminophen pharmacokinetics

(rats), 94Inositol trisphosphate, effect of carbachol,

contraction, iris sphincter muscle(rabbits), 574

Inotropismamiloride, myocardial and vascular ac-

tions, SHR rats, 365

Index 9671986

AR-Li#{174}cardiotonics, mechanism of ac-tion (cats), 375

Inturrisi, C. B., see Yoburn, B. C., 132lothalamate, renal disposition, morphine

tolerance, xenobiotics (mice), 346

Iris sphincter muscle, effect of carbachol,myosin light chain phosphorylation,contraction (rabbits), 574

Isoenzymes, N-acetyltransferase, identifi-cation and inheritance, peripheralblood (hamsters), 823

Isoproterenolablation of myenteric plexus, alpha adre-

nergic response, jejunal longitudinalmuscle (rats), 9

adenylate cyclase, ureter homogenate(guinea pigs), 99

beta adrenoceptorsbovine anterior descending coronary ar-

tery, homogenous population, 634down regulation, 549 lymphoma cells,

654modulation, cytotoxic T cell generation

(mice), 460forskolin and, uterine relaxation, cyclic

AMP (rats), 236

Jarry, H., Lookingland, K. J, Palmer, J. R.

and Moore, K. E.: Neurochemicalcharacterization of the actions of 5-amino-2,4-dihydroxy-a-methylphen-ylethylamine (5-ADMP): A selectiveneurotoxin to central noradrenergicneurons, 55

Jay, M., see Gillespie, M. N., 836Jejunum, longitudinal muscle, impaired a!-

pha adrenergic responses, ablation ofmyenteric plexus (rats), 9

Kachur, J. F., Morgan, D. W. and Gaginella,

T. S.: Effect of dextromethorphan onguinea pig ileal contractility in vitro:Comparison with levomethorphan,loperamide and codeine, 627

Kadowitz, P. J., see Kriseman, T., 395Kainic acid, limbic seizure-brain damage

syndrome, efficacy of bacbofen andphenobarbital (rats), 612

Kajiwara, A., see Ohizumi, Y., 243Kaniucki, M. D., Elverdin, J. C., Luchelli-

Fortis, M. A., Perec, C. J. and Ste-fano, F. J. E.: Sympathetic and par-asympathetic nerves regulate post-synaptic alpha-2 adrenoceptor in sal-ivary glands, 488

Kastin, A. J., see Banks, W. A., 668Kataoka, Y., Fujimoto, M., Alho, H., Gui-

dotti, A., Geffard, M., Kelly, G. D.and Hanbauer, I.: Intrinsic gammaaminobutyric acid receptors modu-late the release of catecholaminefrom canine adrenal gland in situ, 584

Katsube, N., Schwartz, D. and Needleman,P.: Atriopeptin turnover: Quantita-tive relationship between in vivochanges in plasma levels and atrialcontent, 474

Katsuragi, T., see Harada, T., 554Katusic, Z. S., see Zander, J. F., 760Katz, J. L. and Goldberg, S. R.: Effects of

ethylketazocine and morphine onschedule-controlled behavior in pi-geons and squirrel monkeys, 433

Katzman, N. J., see Shannon, H. B., 166

Kauffman, R. F., see Hayes, J. S., 375Kau, S. T., see Barrett, R. J., 365Kaylor, G., see Costa, L. G., 32KB-944, calcium entry blockade, vulnera-

bility toward ventricular fibrillation(dogs), 340

Kelly, G. D., see Kataoka, Y., 584Khac, L. D., Mokhtari, A. and Harbon, S.:

A re-evaluated role for cyclic AMP inuterine relaxation. Differential effectof isoproterenol and forskolin, 236

Khatter, J. C., Agbanyo, M., Hoeschen, R.J., Navaratnam, S. and Bains, R.:Digitalis-induced mechanical toxic-

ity: Protection by slow Ca� channel

blockers, 206Khazaeli, M. B., see Patterson, E., 179Khosla, M. C., see Baker, K. M., 790Kidney

adenosine transport, effects of papaverineand theophylline (rats), 748

gentamicin nephrotoxicity (dogs), 946morphine tolerance, disposition, xeno-

biotics (mice), 346Kilbinger, H., see D’Agostino, G., 522Kiritsy-Roy, J. A., Appel, N. M., Bobbitt, F.

G. and Van Loon, G. R: Effects ofMu-opioid receptor stimulation inthe hypothalamic paraventricularnucleus on basal and stress-inducedcatecholamine secretion and cardio-vascular responses, 814

Kirlin, W. G., see Hem, D. W., 823Klassen, R. D., see Gilbert, S. G., 891Kobayashi, J., see Ohizumi, Y., 243Kojima, S., see Gillespie, M. N., 836Kolm, P., see Shirasaki, Y., 861Koopmans, R. P., see Oosterhuis, B., 919Kopaciewicz, L., see Kopia, G. A., 641Kopia, G. A., Kopaciewicz, L. J. and Ruffobo,

R. R., Jr.: Alpha adrenoceptor regu-lation of coronary artery blood flowin normal and stenotic canine corn-nary arteries, 641

Kopin, I. J., see Zukowska-Grojec, Z., 480Kosobud, A., see Crabbe, J. C., 154, 327Kot, P. A., see Van Dam, J., 390Krauss, E., Polnaszek, C. F., Scheeler, D.

A., Halsall, H. B., Eckfeldt, J. H. andHoltzman, J. L.: Interaction betweenhuman serum albumin and a1-acidglycoprotein in the binding of lido-caine to purified protein fractions

and sera, 754Kreulen, D. L., see Schumann, M. A., 618Kriseman, T., Underwood, D. C., Hyman,

A. L. and Kadowitz, P. J.: Analysisof airway responses to A23187 in thecat, 395

Kruger, H. S., see Boisse, N. R., 775Kunitomo, M., see Gillespie, M. N., 836Kunze, D. L., Andresen, M. C. and Torres,

L. A.: Do calcium antagonists act di-rectly on calcium channels to alterbaroreceptor function?, 303

L-652,73i, platelet activating factor recep-tor antagonist, profile (rats), 841

Labat, C., see Haye-Legrand, I., 536Labetalol

dilevabol, cardiac electrophysiobogical ac-

tions (dogs), 719endothelial potentiation of relaxation re-

sponse, beta adrenoceptor blockingagent (rats), 797

Laher, I., Nishimura, S. and Bevan, J. A.:Prazosin selectively antagonizes nor-

epinephrine contractions at bow-af-finity, non-alpha adrenoceptor sites

(extraceptors) in arterial muscle, 846Lakshmanan, M. R., Campbell, B. S., Chir-

tel, S. J., Ekarohita, N. and Ezekiel,M.: Studies on the mechanism of ab-sorption and distribution of 2,3,7,8-tetrachlorodibenzo-p-dioxin in therat, 673

Lapadula, D. M., see Patton, S. E., 597Larrey, D., see Letteron, P., 559Laursen, S. E., see Crabbe, J. C., 154Lead

poisoning in children, metal excretion inchelation therapy, 829

uptake into brain and soft tissues, effectof intravenous ferric or aluminumchloride (rats), 548

zinc and copper decorporation, treatmentof lead-poisoned children, 829

Lee, C.-H., see Tsujimoto, G., 411Lee, D. K. H., see Rimele, T. J., 1Lee, E. K., see Waszczak, B. L., 606Lee, T. J.-F., see Fukuda, S., 264Lee, T. J.-F., see Shirasaki, Y., 861Lee, T., see Stephens, R. L., Jr., 627Leibach, F. H., see Ganapathy, V., 192Lethality, opioid receptor upregulation,

pharmacodynamic supersensitivity

(mice), 132

Letteron, P., Descatoire, V., Larrey, D.,DeGott, C., Tinel, M., Geneve, J. andPessayre, D.: Pre- or post-treatmentwith methoxsalen prevents the hep-atotoxicity of acetaminophen inmice, 559

Leucine, carrier-mediated transport, blood-brain barrier, Tyr-MIF-i (mice), 668

Leukotriene D4, thromboxane and prosta-cyclin biosynthesis, lung (guineapigs), 63

Levomethorphan, dextromethorphan effecton ileal contracility, compared withboperamide and codeine (guinea pigs),627

Levy, G., see Lin, J. H., 94Lidocaine

binding, interaction, human serum albu-mm and a1-acid glycoprotein, 754

intracerebroventricular injection ofTMB-8, antinociception production

(mice), 320Liebson, I. A., see Griffiths, R. R., 416Lindheimer, M. D., see Nagahama, S., 426Lin, J. H. and Levy, G.: Effect of prevention

of inorganic sulfate depletion on thepharmacokinetics of acetaminophenin rats, 94

Lin, T.-M., Evans, D. C., Warrick, M. W.

and Pioch, R. P.: Actions of nizati-dine, a selective histamine H2-recep-tor antagonist, on gastric acid seers-tion in dogs, rats and frogs, 406

Lin, T.-M., Evans, D. C., Warrick, M. W.

and Ruffolo, R. R., Jr.: Actions ofnizatidine on the rat uterus, dogstomach and experimentally induced

gastric lesions, 400Lipolysis, suppression of free fatty acids and

triglycerides, phenylisopropyladeno-sine (rats), 715

Lithium, furosemide natriuresis, tubularsites (rats), 211

968 Index Vol. 239

Liu-Chen, L.-Y., see Tam, S. W., 351Liver

glutathione conjugation, a-bromoisoval-erylurea, 905

2,3,7,8-tetrachlorodibenzo-p-dioxin,mechanism of absorption and distri-bution (rats), 673

Lookingland, K. J., see Jarry, H., 55Loperamide, dextromethorphan effect on

ileal contractility, compared with 1ev-omethorphan and codeine (guineapigs), 627

Lucchesi, B. R., see Lynch, J. J., 340, 719Lucchesi, B. R., see Patterson, E., 179Luchelli-Fortis, M. A., see Kaniucki, M. D.,

488Luchowski, E. M., see Wei, X. Y., 144Lung

beta adrenoceptors, effects ofpindobol andpropranolol, lymphocytes, 117

visualization, vasoactive intestinal pep-tide receptors (humans, guinea pigs),249

Luteinizing hormone, LHRH-stimulated,follicle-stimulating hormone, alcoholeffects (monkeys), 693

LY 165163, central serotonin agonist ac-tions (rats), 454

LY171555, mechanism of depressor action(rats), 426

Lyddane, J. E., see Thomas, B. F., 48Lygren, I., see Gunnes, P., 915Lymphocytes, beta adrenoceptors, effects of

pindolol and propranolol, 117Lymphoma cells, 549, beta adrenoceptors,

down regulation, 654Lynch, J. J., Montgomery, D. G. and Luc-

chesi, B. R.: The effects of calciumentry blockade on the vulnerabilityof infarcted canine myocardium to-ward ventricular fibrillation, 340

Lynch, J. J., Montgomery, D. G. and Luc-chesi, B. R.: Cardiac electrophysio-logic actions of SCH 19927 (dile-valol), the R,R-isomer of labetabol,719

Maan, A. C., Ptasienski, J. and Hosey, M.M.: Influence of Mg� on the effectof diltiazem to increase dihydropyri-dine binding to receptors on Ca�-channels in chick cardiac and skele-tal muscle membranes, 768

Macrophages, vascular smooth muscle cellsand, ouabain and canrenone, cationhandling (mice), 867

Maddox, Y. T., see Mostaghim, R., 797Maddox, Y. T., see Van Dam, J., 390Magnesium, influence on diltiazem effect,

increased dihydropyridine binding,cardiac and skeletal muscle mem-branes (chicks), 768

Mahesh, V. B., see Ganapathy, V., 192Marks, M. J., see Miner, L. L., 853Marks, M. J., Stitzel, J. A. and Collins, A.

C.: Dose-response analysis of nic-otine tolerance and receptor changesin two inbred mouse strains, 358

Martin, B. R, see Thomas, B. F., 48Mast cells, receptor-stimulated histamine

release, ethanol’s membrane actions(rats), 111

Matsuda, T., see Asano, M., 198Matthews, R. T., McMillen, B. A., Sallis, R.

and Blair, D.: Effects of BMY 14802,a potential antipsychotic drug, on ratbrain dopaminergic function, 124

McConnaughey, M. M., see Garris, D. R.,270

McGuffee, L. J., see Wheeler-Clark, E. S.,286

McLean, A. J., see Corbett, H., 517McMillen, B. A., see Matthews, R. T., 124Meijer, D. K. F., see te Koppele, J. M., 905Mello, N. K., Mendelson, J. H., Bree, M. P.

and Skupny, A. S. T.: Alcohol effectson luteinizing hormone-releasinghormone stimulated luteinizing hor-mone and follicle-stimulating hor-mone in ovariectomized female rhe-sus monkeys, 693

Mellstrom, B., ladarola, M. J., Yang, H.-Y.T. and Costa, E.: Inhibition of met6-enkephalin-ar�-phe7 degradation byinhibitors of dipeptidyl carboxypep-tidase, 174

Membranes, correlation of ethanol’s ac-tions, inhibited histamine release,mast cells (rats), 111

Mendelson, J. H., see Mello, N. K., 693Mercapturates, glutathione conjugation, a-

bromoisovalerylurea as model sub-

strate, 898Met6-enkephalin-Arg�-Phe7, degradation in-

hibition, dipeptidyl carboxypeptidaseinhibitors (rats), 174

Methionine-enkephalinrelease from myenteric plexus, endoge-

nous opioids and exogenous mor-

phine (guinea pigs), 742spinal release, analgesia production, ster-

eoselective effect of f�-endorphin(rats), 160

Methoxsalen, pre- or post-treatment with,acetaminophen toxicity prevention(mice), 559

N-Methyl-D-aspartic acid, folates, excita-tory amino acid receptors, locomotoractivity (rats), 627

Miller, J. R., Hawkins, D. J. and Wells, J.N.: Phorbol diesters alter the con-tractile responses of porcine coronaryartery, 38

Miner, L. L., Marks, M. J. and Collins, A.C.: Genetic analysis of nicotine-in-duced seizures and hippocampal ni-cotinic receptors in the mouse, 853

Minneman, K. P., see Abel, P. W., 678Minoshima, S., see Ohizumi, Y., 243Mitochondria, digitalis mechanical toxicity,

protection by slow calcium channelblockers (guinea pigs), 206

Miyamoto, Y., see Ganapathy, V., 192Mokhtari, A., see Khac, L. D., 236Molinoff, P. B., see Contreras, M. L., 136Molinoff, P. B., see Hedberg, A., 117Molinoff, P. B., see Reynolds, E. E., 654Molloy, B. B., see Fuller, R. W., 454Mong, S., Wu, H.-L., Clark, M. A., Gleason,

J. G. and Crooke, S. T.: LeukotrieneD4 receptor-mediated synthesis andrelease of arachidonic acid metabo-bites in guinea pig lung Induction ofthromboxane and prostacyclin bio-

synthesis by leukotriene D4, 63Montgomery, D. G., see Lynch, J. J., 340,

719

Montgomery, D. G., see Patterson, E., 179Moore, K. E., see Jarry, H., 55

Morgan, D. W., see Kachur, J. F., 627M#{248}rland,J., see Bodd, E., 887Morphine

conjugation, inhibitory effect of ethanol

in hepatocytes, mechanisms (rats),887

ethylketazocine and, effects on schedule-controlled behavior (pigeons, mon-keys), 433

exogenous, methionine-enkephalin re-lease, myenteric plexus (guinea pigs),

742intracerebroventricular injection of

TMB-8, antinociception production(mice), 320

tolerance, renal disposition, xenobiotics

(mice), 346Mostaghim, R., Maddox, Y. T. and Ram-

well, P. W.: Endothelial potentiationof relaxation response to beta adre-noceptor blocking agents, 797

Mulder, G. J., see te Koppele, J. M., 898,905

Muramatsu, I., see Ueda, N., 494Murphy, S. D., see Costa, L. G., 32Muscle, heart, dihydropyridine binding to

calcium channel receptors, effect ofdiltiazem, influence of magnesium(chicks), 768

Muscle, longitudinal, substance B isolation,presynaptic modulation (guineapigs), 185

Muscle, skeletaldihydropyridine binding to calcium chan-

nel receptors, effect of diltiazem, in-fluence of magnesium (chicks), 768

geographutoxin II, sodium channel inhib-itor (mice, bullfrogs, guinea pigs, rab-bits), 243

Muscle, smoothafter contractile responses, phorbol dies-

ters, coronary artery (hogs), 38calcium redistribution, renal artery, elec-

tron microscopic autoradiography(rabbits), 286

1,4-dihydropyridine activator-antagonistpairs, radioligand binding analysis(rats, guinea pigs), 144

extraneuronal serotonin uptake, mecha-nisms, aorta (rats), 264

phorbol butyrate contractions in aorta,calcium dependence, 8-Br-cyclicGMP, 78

uterine relaxation, cyclic AMP, iso-proterenol and forskolin (rats), 236

vascularcyclic AMP concentrations, endoge-

nous prostaglandins (rats), 334decreased beta responsiveness (hu-

mans), 802

effects of naftidrofuryl, blood vessels(dogs), 760

ouabain and canrenone, cation han-cUing (mice), 867

relaxation, age-related decrease (rats),411

Muscle cells, dextromethorphan effect onileal contractility, compared with 1ev-

omethorphan, loperamide and co-deine (guinea pigs), 627

Myenteric plexusablation, impaired alpha adrenergic re-

sponses, jejunal longitudinal muscle

(rats), 9methionine-enkephalin release, endoge-

1986 Index 969

nous opioids and exogenous mor-

phine (guinea pigs), 742substance B isolation, presynaptic modu-

lation (guinea pigs), 185Myocardium

calcium entry blockade, vulnerability to-ward ventricular fibrillation (dogs),340

effects of activated neutrophils (rabbits),836

infarctionischemia, secretin infusion (dogs), 915

Myo-inositol trisphosphate, effect of car-bachol, contraction, iris sphinctermuscle (rabbits), 574

Myometrium, uterine relaxation, cyclic

AMP, isoproterenol and forskobin(rats), 236

Naderi, S., see Howe, P. H., 574Nadler, J. V., see Ault, B., 612Naftidrofuryl, vascular effects (dogs), 760Nagahama, S., Chen, Y.-F., Lindheimer, M.

D. and Oparil, S.: Mechanism of thedepressor action of LY171555, a se-lective dopamine D2 receptor agonist,in the anesthetized rat, 426

Nahorski, S. R., see Rooney, T. A., 873Nakagawa, C., see Honda, K., 512Nakamura, H., see Ohizumi, Y., 243Nakanishi, S., see Ueda, N., 494Naloxone

acute chlordiazepoxide dependence, phar-macologic characterization (rats),775

effects of ethylketazocine and morphine,schedule-controlled behavior (pi-geons, monkeys), 433

Naltrexone, opioid receptor upregulation,

pharmacodynamic supersensitivity(mice), 132

Narumiya, S. and Fukushima, M.: Site andmechanism of growth inhibition byprostaglandins. I. Active transportand intracellular accumulation of cy-clopentenone, prostaglandins, a re-action leading to growth inhibition,500

Narumiya, S., Ohno, K., Fujiwara, M. andFukushima, M.: Site and mechanismof growth inhibition by prostaglan-dims. II. Temperature-dependenttransfer of a cyclopentenone prosta-glandin to nuclei, 506

Nasjletti, A., see Erman, A., 296Natriuresis, furosemide, tubular sites (rats),

211

Navaratnam, S., see Khatter, J. C., 206Needleman, P., see Katsube, N., 474Nephrotoxicity, gentamicin (dogs), 946Neuroblastoma cells, N1E-115, effects of

chronic ethanol exposure, prosta-glandin E1 receptor-mediated re-sponse (mice), 687

Neurokinin A, substance P and electricalstimulation, effects on iris sphinctermuscle (rabbits), 494

Neuroleptic drugs, effects of BMY 14802,brain dopaminergic function (rats),

124Neuromuscular junction

end-plate current, effects of phencyclidineand analogs (frogs), 15

thienyl analog of phencyclidine, acetyl-

choline receptor, blockade and recov-ery (frogs), 25

Neurons

central noradrenergic, 5-amino-2,4-dihy-

droxy-a-methylphenylethylamine,neurochemical characterization(rats), 55

dopaminergic, effects of BMY 14802,brain (rats), 124

inferior mesenteric ganglion, action ofcholecystokinin octapeptide andCCK-related peptides (guinea pigs),618

Neurotoxicity

anticonvulsant drugs, temporal lobe epi-lepsy, quinoline acid (rats), 256

tri-O-cresyl-induced delay, enhancedphosphorylation, brain and spinalcord proteins (hens), 597

Neurotoxins, 5-amino-2,4-dihydroxy-a-methylphenylethylamine, neuro-

chemical characterization, centralnoradrenergic neurons (rats), 55

Neutrophils, activated, coronary and myo-cardial effects (rabbits), 836

Nickols, G. A., see Shirasaki, Y., 861Nicotine

induced seizures, nicotinic receptors, ge-netic analysis (mice), 853

tolerance, dose-response analysis, recep-tor changes (mice), 358

Nies, A. S., see Hedberg, A., 117Nifedipine

alpha adrenoceptor-mediated vasocon-striction (dogs, monkeys), 648

verapamil and diltiazem, norepinephrine

contractions, potentiation (rabbits,swine), 808

Nishimura, S., see Laher, I., 846Nitrendipine

action on calcium channels, baroreceptorfunction (rats), 303

calcium redistribution, renal artery, elec-

tron microscopic autoradiography(rabbits), 286

Nitroglycerinpharmacokinetics, determinant, cardiac

output (rats), 701vascular relaxation, decreased beta re-

sponsiveness (humans), 802Nitrovasodilators

aging and hypertension, endothelial mod-ulation of vascular relaxation (rats),861

phorbol dibutyrate contractions, aorta, 78Nizatidine

actions on uterus and stomach (rats,dogs), 400

effect on gastric acid secretion (dogs, rats,frogs), 406

NMDA, see N-Methyl-D-aspartic acidNoda, H., see Watkins, J. B., III, 467Nomifensine, modulation of dopamine re-

lease, D-2 dopamine receptors, stria-tal slices (rats), 442

Norepinephrine

5-amino-2,4-dihydroxy-a-methylphenyl-ethylamine, neurochemical charac-terization, central noradrenergic neu-rons (rats), 55

atrial natriuretic peptide, interactions,sympathetic and endocrine systems(rats), 480

beta adrenoceptors, modulation, cytotoxicT cell generation (mice), 460

beta-i adrenoceptors, bovine anterior de-scending coronary artery, homoge-nous population, 634

contraction potentiation, verapamil, dil-

tiazem and nifedipine (rabbits,swine), 808

contractions, prazocin-sensitive adre-noceptors, arterial muscle (rabbits),846

estrogen modulation, adrenergic-cholin-ergic interaction, uterus (guineapigs), 270

phosphoinositide metabolism, effect ofchronic cholinesterase inhibition,

brain (rats), 32Nucleus accumbens

activation of excitatory amino acid recep-tors, folates, locomotor activity(rats), 627

dopamine release, preferential stimula-tion, ethanol (rats), 219

Nunes, F. A., see Yoburn, B. C., 132

Ogolla, F., see Hem, D. W., 823Ohizumi, Y., Minoshima, S., Takahashi, M.,

Kajiwara, A., Nakamura, H. and Ko-

bayashi, J.: Geographutoxin II, anovel peptide inhibitor of Na chan-nels of skeletal muscles and auto-nomic nerves, 243

Ohlstein, E. H. and Berkowitz, B. A.: Hu-man vascular vasopressin receptors:Analysis with selective vasopressinreceptor antagonists, 737

Ohno, K., see Narumiya, S., 506Olde Boerrigter, J. C., see te Koppele, J. M.,

898Oosterhuis, B., ten Berge, I. J. M., Schellek-

ens, P. T. A., Koopmans, R. P. andvan Boxtel, C. J.: Prednisolone con-

centration-effect relations in humansand the influence of plasma hydro-cortisone, 919

Oparil, S., see Nagahama, S., 426Opiates, acute chlordiazepoxide depend-

ence, pharmacologic characterization(rats), 775

Opioid antagonists, receptor binding, a-fun-

altrexamine, brain membranes(guinea pigs), 351

Opioidsendogenous, methionine-enkephalin re-

lease, myenteric plexus (guinea pigs),742

mu receptor stimulation, catecholaminesecretion, brain and cardiovascularresponses (rats), 814

receptor upregulation, pharmacodynamic

supersensitivity (mice), 132spinal adenosine, modulated antinocicep-

tive pathways, morphine stimulation(mice), 88

Organic anions, biliary excretion, diabetes(rats), 467

Organophosphatesacetylcholinesterase inhibitor, clonidine

protection (mice), 43carbamate compounds and, pre- and post-

junctional effects, glutamatergic syn-apse (locusts), 279

effects of chronic cholinesterase inhibi-tion, brain (rats), 32

Ouabaindigitalis mechanical toxicity, protection

970 Index Vol. 239

by slow calcium channel blockers(guinea pigs), 206

disturbances ofcation handling, effects of

canrenone, macrophages and vascu-lar smooth muscle cells (mice), 867

Ovarian suspensory ligament, effects of betaadrenoceptors, agonists and antago-nists (rats), 591

Oxytocin antagonists, prolonged action, po-tential tocolytic agents, preterm la-bor (rats), 84

Pajka, S. F., see Husain, A., 71Palmer, J. R., see Jarry, H., 55Pan, H. Y.-M., Hoffman, B. B., Pershe, R.

A. and Blaschke, T. F.: Decline inbeta adrenergic receptor-mediatedvascular relaxation with aging inman, 802

Papaverine, theophylline and, effects on

renal adenosine transport (rats), 748Parasympathetic nerves, sympathetic

nerves and, postsynaptic a4,ha-2 ad-renoceptor regulation, salivaryglands (rats), 488

Pardridge, W. M., see Terasaki, T., 724Park, S. H., see Deane, R., 548Pasternak, G. W., see Yoburn, B. C., 132Patterson, E., Walden, K. M., Khazaeli, M.

B., Montgomery, D. G. and Lucchesi,B. R.: Cardiac electrophysiologic ef-fects of acute and chronic arnioda-rone administration in the isolatedperfused rabbit heart: Altered thyroidhormone metabolism, 179

Patton, S. E., Lapadula, D. M. and Abou-Donia, M. B.: Relationship of tri-o-cresyl phosphate-induced delayed

neurotoxicity to enhancement of invitro phosphorylation of hen brainand spinal cord proteins, 597

Pearce, L. B., see Benishin, C. G., 185Peptides

CCK-related and cholecystokinin octa-peptide, neurons in inferior mesen-

teric ganglion (guinea pigs), 618

Tyr-MIF-1, carrier-mediated transportacross blood-brain barrier, essentialamino acids (mice), 668

vasoactive intestinal, visualization, lung

(humans, guinea pigs), 249

Perec, C. J., see Kaniucki, M. D., 488Pergolide, modulation of dopamine release,

D-2 dopamine receptors, striatalslices (rats), 442

Periana, R. M., see Boisse, N. R., 775Perico, N., Zoja, C., Benigni, A., Ghilardi,

F., Gualandris, L. and Remuzzi, G.:Effect of short-term cyclosporine ad-ministration in rats on renin-angio-tensin and thromboxane A2: Possiblerelevance to the reduction in gbomer-

ular filtration rate, 229Perio, A., Chambon, J.-P., Calassi, R.,

Heaulme, M. and Biziere, K.: Evalu-ation of two anticonvulsant amino-pyridazine derivatives in the conflicttest in rats, 542

Pershe, R A., see Pan, H. Y.-M., 802Pessayre, D., see Letteron, P., 559Petersen, B. H., see Hatfield, S. M., 460Pfenning, M., see Richelson, E., 687Pharmacogenetics, ethanol sensitivity and

tolerance, WSP and WSR mouse

lines, 327

Pharmacokinetics, atriopeptin, changes inplasma levels and atrial content(rats), 474

Phencyclidineeffects on end-plate current, neuromus-

cular junction (frogs), 15modified effects, ammonium chloride

(rats), 48thienyl analog, acetylcholine receptor,

blockade and recovery (frogs), 25Phenobarbital, baclofen and, efficacy

against kainic acid limbic seizure-brain damage syndrome (rats), 612

Phenoxybenzamine, low-affinity adre-noceptors, norepinephrine contrac-tions, arterial muscle (rabbits), 846

Phenylisopropyladenosine, suppression offree fatty acids and triglycerides(rats), 715

Phorbol-12,13-dibutyratecontractile responses, coronary artery

(swine), 38

contractions in aorta, calcium depend-ence, 8-Br-cyclic GMP, 78

Phorbol esters, effect of carbachol, contrac-tion, iris sphincter muscle (rabbits),574

Phorbol myristate acetate, activated neutro-phils, coronary and myocardial ef-fects (rabbits), 836

Phosphatidylinositol 4,5-bisphosphate, ef-feet of carbachol on myosin lightchain phosphorylation, contraction,iris sphincter muscle (rabbits), 574

Phosphodiesterase, AR-Li#{174} cardiotonics,mechanism of action (cats), 375

Phosphoinositide, carbachol- and norepi-nephrine-stimulated, effect ofchronic cholinesterase inhibition(rats), 32

Phosphoinositide hydrolysis, depolariza-tion-induced, regional characteriza-

tion of agonist (rats), 873Phosphoprotein phosphatases, tri-O-cresyl

phosphate-induced delayed neuro-toxicity, brain and spinal cord pro-teins (hens), 597

Phosphorylationmyosin light chain, effect ot carbachol,

contraction of iris sphincter muscle(rabbits), 574

tri-O-cresyl phosphate-induced delayedneurotoxicity, brain and spinal cordproteins (hens), 597

Pindololbeta adrenoceptors

down regulation, S49 lymphoma cells,654

propranolol, lymphocytes, 117Pioch, R P., see Lin, T.-M., 406Placenta, sodium-hydrogen exchanger, in-

hibition by cimetidine, 192

Plasmahydrocortisone, prednisolone concentra-

tion-effect relations (humans), 919protein binding, bupivacaine transport,

brain and salivary gland (rats), 724Plasma membrane, calcium redistribution,

renal artery, electron microscopic au-toradiography (rabbits), 286

Platelet-activating factor, antagonist L-652,731, profile (rats), 841

Polnaszek, C. F., see Krauss, E., 754Polyphosphoinositides, effect of carbachol,

contraction, iris sphin#{233}ter muscle(rabbits), 574

Potassium, depolarization-induced phos-phoinositide hydrolysis, regionalcharacterization ofagonist (rats), 873

Potassium channel, ouabain and canrenone,macrophages, vascular smooth mus-cle cells (mice), 867

Poulakos, J. J. and Gertner, S. B.: Studieson the desensitization of the centralcardiovascular responses of hista-mine, 730

Practololablation of myenteric plexus, alpha adre-

nergic response, jejunal longitudinalmuscle (rats), 9

bovine anterior descending coronary ar-

tery, beta-i adrenoceptors, homoge-nous population, 634

Prazocinablation of myenteric plexus, alpha adre-

nergic response, jejunal longitudinalmuscle (rats), 9

low-affinity adrenoceptors, blood vessels(rabbits), 846

Prednisolone, concentration-effect rela-tions, influence of plasma hydrocor-tisone (man), 919

Pregnancychronically consumed caffeine, elimina-

tion (monkeys), 891preterm labor, oxytocin anatagonists, pro-

longed action (rats), 84Procaine, intracerebroventricular injection

of TMB-8, antinociception produc-tion (mice), 320

Progesterone, estrogen modulation, adre-nergic-cholinergic interaction, uterus(guinea pigs), 270

Prolactin, LY 165163, central serotonin ag-onist actions (rats), 454

Propranololablation of myenteric plexus, alpha adre-

nergic response, jejunal longitudinalmuscle (rats), 9

oral hydralazine and, interaction (dogs),517

pindolol and, beta adrenoceptors, lympho-cytes, 117

Prostacyclincontractile response, role of vascular en-

dothelium, isolated aorta (rats), 390thromboxane and, leukotriene D4, lung

(guinea pigs), 63

Prostaglandin E1, effects of chronic ethanolexposure, neuroblastoma clone(mice), 687

Prostaglandin E�enprostil, gastric antisecretory and an-

tiulcer properties (rats), 382uterine relaxation, cyclic AMP, iso-

proterenol and forskolin (rats), 236Prostaglandins

endogenous, cyclic AMP concentrations,vascular smooth muscle cells (rats),334

increased glomerular synthesis, dexa-methasone treatment (rats), 296

role, airway muscle contraction, hista-mine (humans), 536

site and mechanism of growth inhibition,

500Prostate, alpha-i adrenoceptor antagonist

effects, optical isomers of YM-12617(rabbits), 512

Proteinislet-activating, inhibited adenylate cy-

clase, -y-aminobutyric acid B (rats),

1986 Index 971

568

myosin light chain, effect of carbachol,contraction of iris sphincter muscle(rabbits), 574

Protein kinase, tri-O-cresyl-induced delayedneurotoxicity, enhanced phosphory-lation, brain and spinal cord proteins(hens), 597

Protein kinase Cphorbol dibutyrate contractions, aorta, 78phorbol diesters, after contractile re-

sponses, coronary artery (swine), 38Proximal tubules, sites of furosemide natri-

uresis (rats), 211Ptasienski, J., see Maan, A. C., 768Purdy, R. E. and Stupecky, G. L.: Bovine

anterior descending coronary artery

possesses a homogeneous population

of beta-i adrenergic receptors, 634Pyridylethylamine, central cardiovascular

responses, histamine, desensitization(rats), 730

Quinoline acid, anticonvulsant drugs, tem-poral lobe epilepsy (rats), 256

Radioligands

binding analysis, 1,4-dihydropyridine ac-tivator-antagonist pairs, smoothmuscle (rats, guinea pigs), 144

monoiodinated angiotensin II, full agonistanalog of angiotensin II, 71

Raffestin, B., see Haye-Legrand, I., 536Ramwell, P. W., see Mostaghim, R., 797Ramwell, P. W., see Van Dam, J., 390Reaven, G. M., see Hoffman, B. B., 715Receptor agonists

monoiodinated angiotensin II, biologicalactivity, 71

substance B isolation, presynaptic modu-lation (guinea pigs), 185

Receptorsacetylcholine, blockade and recovery,

thienyl analog of phencyclidine(frogs), 25

adenosine, free fatty acids and triglycer-ides, phenylisopropyladenosinesuppression (rats), 715

adrenergic, see Adrenoceptorsadrenoceptors, see Adrenoceptorsbaroreceptors, calcium antagonists, ac-

tion on calcium channels (rat), 303cholecystokinin, acetylcholine release,

spinchter of Oddi (guinea pigs), 554D-2 dopamine, robust modulation, stria-

tal slices (rats), 442epsilon opioid, Met-enkephalin release, �-

endorphin effect (rats), 160excitatory amino acid, folates, locomotor

activity (rats), 627mu-opioid, effects on catecholamine se-

cretion (rats), 814muscarinic

acetylcholine release, urinary bladder(rats), 522

phosphoinositide metabolism, chroniccholinesterase inhibition (rats), 32

soman toxicity, clonidine protection(mice), 43

nicotinicacetylcholine receptor and, thienyl an-

alog of phencyclidine (frogs), 25nicotine-induced seizures, genetic

analysis (mice), 853phencyclidine and its analogs, end-

plate current of neuromuscular junc-

tion (frogs), 15tolerance, dose-response analysis

(mice), 358opioid, �l-funaltrexamine binding, brain

membranes (guinea pigs), 351vasoactive intestinal peptide, visualiza-

tion, lung (humans, guinea pigs), 249vasopressin, analysis with antagonists

(humans), 737

Reflexes, loss of righting, ethanol sensitivityand tolerance, WSP and WSR mouselines, 327

Reiker5s, 0., see Gunnes, P., 915Remuzzi, G., see Perico, N., 229Renal artery, calcium redistribution, elec-

tron microscopic autoradiography(rabbits), 286

Renin-angio�ensin system, short-term cy-closporine administration, glomeru-lar filtration rate (rats), 229

Reynolds, E. E. and Molinoff, P. B.: Downregulation of beta adrenergic recep-tors in S49 lymphoma cells inducedby atypical agonists, 654

Rice, D. C., see Gilbert, S. G., 891Richelson, E., Stenstrom, S., Forray, C., En-

lee, L. and Pfenning M.: Effects ofchronic exposure to ethanol on theprostaglandin E1 receptor-mediatedresponse and binding in a murineneuroblastoma clone (N1E-i15), 687

Rickett, D. L., see Idriss, M. K., 279Rimele, T. J., Heaslip, R. J., Lee, D. K. H.

and Grimes, D.: In vitro characteri-zation of the adrenoceptor activity ofAY-28,925, 1

Riviere, J. E., see Frazier, D. L., 946Ro 15-1788, acute chlordiazepoxide depend-

ence, pharmacologic characterization(rats), 775

Robertson, D. W., see Hayes, J. S., 375Robertson, R M., see Hondeghem, L. M.,

808

Rockway, T. W., see Chan, W. Y., 84Rooney, T. A. and Nahorski, S. R.: Regional

characterization of agonist and de-polarization-induced phosphoinosi-

tide hydrolysis in rat brain, 873Rose bengal, biliary excretion, organic an-

ions, diabetes (rats), 467

Roszkowski, A. P., Garay, G. L., Baker, S.,Schuler, M. and Carter, H.: Gastricantisecretory and antiulcer proper-ties of enprostil, (±)- lla,15a-dihy-droxy- 16-phenoxy-i7,18,19,20-te -

tranor-9-oxoprosta-4,5, 13(t)-tn-enoic acid methyl ester, 382

Rubanyi, G. M., see Zander, J. F., 760Ruffolo, R. R., Jr., see Kopia, G. A., 641Ruffolo, R. R., Jr., see Lin, T.-M., 400Rutledge, A., see Wei, X. Y., 144

Salbutamol, bovine anterior descending con-onary artery, beta-i adrenoceptors,homogenous population, 634

Saligenin, tri-O-cnesyl phosphate-induced

delayed neurotoxicity, enhancedphosphorylation, brain and spinalcord proteins (hens), 597

Salivary glandbrain and, bupivacaine transport (rats),

724sympathetic and parasympathetic nerves,

regulation by postsynaptic a!pha-2

adrenoceptor (rats), 488Sallis, R., see Matthews, R. T., 124Samanin, R., see Vezzani, A., 256Samoriski, G. M., see Boisse, N. R., 775Sarcoplasmic reticulum, calcium redistri-

bution, renal artery, electron micro-scopic autoradiography (rabbits), 286

Sawada, Y., see Suzuki, H., 927SCH 19927, cardiac electrophysiologic ac-

tions (dogs), 719Scheeler, D. A., see Krause, E, 754Sehellekens, P. T. A., see Oosterhuis, B.,

919Schuler, M., see Roszkowski, A. P., 382Schumann, M. A. and Kreulen, D. L.: Action

of cholecystokinin octapeptide andCCK-related peptides on neurons ininferior mesentenic ganglion ofguinea pig, 618

Schwartz, D., see Katsube, N., 474Secretin, infusion, acute isehemic left yen-

tricular failure (dogs), 915Seizures

anticonvulsant drugseffects on substantia nigra pars reticu-

lata neurons, 606temporal lobe epilepsy, quinoline acid

(rats),256nicotine-induced, nicotinic receptors, ge-

netic analysis (mice), 853Serotonin

agonist actions of LY 165163 (rats), 454extraneuronal uptake, mechanisms, aorta

(rats), 264Serum, albumin and a1-acid glycoprotein,

interaction, lidocaine binding, 754Shannon, H. E. and Katzman, N. J.: CGS

8216: Agonist and diazepam-antago-

nist effects in rodents, 166

Shirasaki, Y., Su, C., Lee, T. J.-F., Kolm,P., Cline, W. H., Jr. and Nickols, G.A.: Endothelial modulation of vascu-bar relaxation to nitrovasodilators inaging and hypertension, 861

SK&F 101926, vascular vasopressin recep-tors, analysis (humans), 737

Skupny, A. S. T., see Mello, N. K., 693Snoddy, H. D., see Fuller, R. W., 454Sodium

channel blocker, amiloride, myocardialand vascular actions (rats), 365

digitalis mechanical toxicity, protectionby slow calcium channel blockers(guinea pigs), 206

Sodium channel, geographutoxin II inhibi-tion, skeletal muscles, autonomicnerves (mice, bullfrogs, guinea pigs,rabbits), 243

Sodium fluoride, guanylyl-5’-imidodiphos-phate and, forskolin binding (rats),952

Sodium-hydrogen exchange, placental

brush-border membrane, inhibitionby cimetidine, 192

Sodium-potassium-ATPase, AR-Li#{174} car-diotonics, mechanism of action(cats),375

Sodium-potassium pump, ouabain and can-renone, macrophages, vascularsmooth muscle cells (mice), 867

Soman, toxicity, clonidine protection(mice), 43

So, Y., see Gilbert, S. G., 891Spealman, R. D., see Bergman, J., 104Species differences, histamine-induced re-

laxation, mechanisms, coronary ar-

972 Index Vol. 239

tenies (monkeys, dogs), 529Speth, R. C., see Husain, A., 71Sphincter muscle, effects of neurokinin A,

substance P and electrical stimula-tion (rabbits), 494

Spinal cordadenosine, modulated antinociceptive

pathways, morphine stimulation(mice), 88

brain and, tri-O-cresyl-induced delayedneurotoxicity, enhanced phosphory-lation (hens), 597

Met-enkephalin release, analgesia pro-duction, stereoselective effect of �-endorphin (rats), 160

Spincter of Oddi, acetylcholine release, cho-lecystokinin receptor mediation(guinea pigs), 554

SQ 29,548, A23i87, analysis of airway re-

sponses (cats), 395SR 41378, anticonvulsant amino-pyridazine

derivatives, evaluation, conflict test(rats), 542

SRS-A, leukotriene D4, thromboxane andprostacyclin biosynthesis, lung(guinea pigs), 63

Stanton, H. C. and Dungan, K. W.: In vitroeffects of beta adrenoceptor agonistsand antagonists on the rat ovariansuspensory ligament, 591

Starke, K., see Szabo, B., 881Stavnic, B., see Gilbert, S. G., 891Stefano, F. J. E., see Kaniucki, M. D., 488Steiness, E., see Christensen, S., 211Stenstrom, S., see Richelson, E., 687Stephens, R. L., Jr., Lee, T., Boldry, R. and

Unetsky, N. J.: Activation of excita-tory amino acid receptors may me-diate a folate-induced stimulation oflocomotor activity after bilateral in-jection into the rat nucleus accum-bens, 627

Stereoisomers, YM-126i7, alpha-i adreno-ceptor antagonist effects (rabbits),512

Stitzel, J. A., see Marks, M. J., 358Stomach

gastric acid secretion, nizatidine actions

(dogs, rats, frogs), 406nizatidine actions, gastric lesions (rats,

dogs), 400Stress, effects of mu-opioid receptor stimu-

lation, brain, catecholamine secre-

tion and cardiovascular responses

(rats), 814Striatum

effects ofBMY 14802, brain dopaminergicfunction (rats), 124

modulation of dopamine release, D-2 do-pamine receptors (rats), 442

Stupecky, G. L., see Purdy, R. E., 634Substance B, isolation, presynaptic modu-

lation (guinea pigs), 185

Substance P, neurokinin A and electricalstimulation, effects on iris sphinctermuscle (rabbits), 494

Substantia nigra, effects of BMY 14802,brain dopaminergic function (rats),124

Substantia nigra pars reticulata, neurons,

effects of anticonvulsant drugs, 606

Su, C. M., see Wei, X. Y., 144Su, C., see Fukuda, S., 264Su, C., see Shirasaki, Y., 861Sugiyama, Y., see Suzuki, H., 927

Sulfobromophthalein, biliary excretion, or-ganic anions, diabetes (rats), 467

S-Sulpinide, modulation of dopamine re-lease, D-2 dopamine receptors, stria-tal slices (rats), 442

Suzuki, H., Sawada, Y., Sugiyama, Y., Iga,T. and Hanano, M.: Transport of ci-metidine by the rat choroid plexus invitro, 927

Sybertz, E. J., Desidenio, D. M., Tetzboff, G.

and Chiu, P. J. S.: Phorbol dibutyratecontractions in rabbit aorta: Calciumdependence and sensitivity to nitro-vasodilators and 8-BR cyclic GMP,78

Sympathetic nervesparasympathetic nerves and, postsynaptic

alpha-2 adrenoceptor regulation, sal-ivary glands (rats), 488

purinergic vasoconstriction, thermosen-sitivity, cutaneous vein (dogs), 784

Sympathetic nervous systembeta adrenoceptors, modulation, cytotoxic

T cell generation (mice), 460endocrine system and, interactions, atnial

natniuretic peptide (rats), 480Synapse, glutamatergic, pre- and postjunc-

tional effects, organophosphates andcarbamate compounds (locusts), 279

Szabo, B., Hedler, L. and Starke, K.:Dopamine1 receptor agonist and at-pha-2 adrenoceptor antagonist ef-fects of fenoldopam in rabbits, 881

Tachykinins, effects on iris sphincter mus-cle (rabbits), 494

Takahashi, M., see Ohizumi, Y., 243Tam,B.,seeCrabbe,J.C., 154Tam, S. W. and Liu-Chen, L.-Y.: Reversible

and irreversible binding of /3-funal-trexamine to mu, delta and kappaopioid receptors in guinea pig brainmembranes, 351

Taniguchi, T., see Ueda, N., 494Taylor, S. M., see Husain, A., 71te Koppele, J. M., Dogterom, P., Vermeulen,

N. P. E., Meijer, D. K. F., van denGen, A. and Mulder, G. J.: a-Bro-moisovalerylurea as model substratefor studies on pharmacokinetics ofglutathione conjugation in the rat. II.Pharmacokinetics and stereoselectiv-ity of metabolism and excretion invivo and in the perfused liver, 905

te Koppele, J. M., van der Mark, E. J., Olde

Boernigter, J. C., Brussee, J., van denGen, A., van den Greef, J. andMulder, G. J.:a-Bromoisovalerylureaas model substrate for studies onpharmacokinetics of glutathione con-

jugation in the rat. I. (Bio-) synthesis,analysis and identification of diaster-

eomeric glutathione conjugates andmercapturates, 898

Temperature, body, dose-response analysis,nicotine tolerance (mice), 358

ten Berge, I. J. M., see Oosterhuis, B., 919Terasaki, T., Pardridge, W. M. and Denson,

D. D.: Differential effect of plasmaprotein binding of bupivacaine on itsin vivo transfer into the brain andsalivary gland of rats, 724

Terbutaline, beta adrenoceptors, modula-tion, cytotoxic T cell generation

(mice), 4602,3,7,8-Tetrachborodibenzo-p-dioxin, mech-

anism of absorption and distribution(rats), 673

12-O-Tetradecanoylphorbol-13-acetate,contractile responses, coronary ar-tery (swine), 38

Tetrahydrocannabinoldependence (monkeys), 311sensory-evoked discharges, granule cells,

dentate gyrus (rats), 941sensory-evoked potentials, dentate gyrus

(rats), 936Tetzloff, G., see Sybertz, E. J., 78Theophylline, papaverine and, effects on

renal adenosine transport (rats), 748Thermosensitivity, sympathetic purinergic

vasoconstriction, cutaneous vein(dogs), 784

Thomas, B. F., Lyddane, J. E. and Martin,B. R.: Modification of behavioral ef-fects and biodisposition of phencycli-dine in rats by ammonium chloride,48

Thomas, D. J. and Chisolm, J. J., Jr.: Lead,zinc and copper decorporation during

calcium disodium ethylenediaminetetraacetate treatment of lead-poi-soned children, 829

Thompson, C., see Frazier, D. L., 946Thompson, L. K., see Hem, D. W., 823Thormann, B., see Hannaert, P., 867Thromboxane

prostacyclin biosynthesis and, leuko-tniene D4, lung (guinea pigs), 63

short-term cyclosporine administration,glomerular filtration rate (rats), 229

Thromboxane A2, A23187, analysis of air-way responses (cats), 395

Thyroid, hormone alteration, cardiac elec-trophysiologic effects, acute andchronic amiodarone (rabbits), 179