703

INDEX

Volume 220, January-March, 1982

Abernethy, D R., see Greenblatt,D. J., 120

Acetaminophen

-induced hepatotoxicity, effects

of insulin-deficient diabeteson (rats), 504

toxicity, effects of propyl-

thyiouradil-induced hyper-

thyroidism and triiodo-L-thy-

ronine-induced hyperthy-roidism (rats), 427

N-Acetylationp-aminobenzoic acid and isoni-

.azid, genetic covariation in

liver (rabbits), 1

polymorphism, pharmacogen-

tic expression (hamsters), 8Acetylcholine

in brain, effects of phosphati-dylcholine on (rats), 322

receptor and channel, inhibi-

tion by d-tubocurarine(frogs), 172

receptors, in isolated atria, ef-

fects of isoproterenol (rats),

411release in striatum, potassium-

evoked, antagonism of neu-roleptic agents of dopamine-induced inhibition of (rats),197

turnover in brain, effects of y-

aminobutyric acid receptoragonists on (rats), 689

1-a-Acetylmethadol (LAAM)-

maintained subjects, electro-encephalographic and behav-ioral cross-tolerance to mor-phine and methadone in(rats), 561

N-Acetyltransferase

activities, monomorphic and

polymorphic, evidence for co-

existence on protein in liver(rabbits), 1

liver, genetic variation (ham-stars), 8

Adamski, S. Wor, see Prasad, C.M., 293

Adenosine, analogs, behavioral ef-

fects (mice, rats), 70Na-K-Adenosine triphosphatase

inhibition by vanadate (rats),

540

stimulation and inhibition by

ouabain (guinea pigs, rabbits,cats), 145

Adrenergic blockade, alpha and

combined alpha and beta, ef-fects on renal and splanchnicblood flows during nicotineinfusion (dogs), 375

Adrenergic receptors, alpha-i, at-pha-2 and beta, competitionby L-a-methyldopa metabo-

lites for (rats), 552

Adrenoceptors ( see also Adrener-

gic receptors)

alpha, antagonist, potency of

amitriptyline (rats), 299

atpha-2, inhibition of intestinalsecretion (rats), 637

beta, selective antagonism byprenalterol (guinea pigs,dogs), 77

beta, irreversible blockade andrecovery in heart and lung(rats), 247

Agonists, dopamine, effect onstriate.! acetylcholine tram-mission (rats), 197

Agonists-antagonists, opioid, ef-fects on body temperature(mice), 468

Aguayo, L. G., see Shaker, N., 172

D-Ala-Met-enkephahnamlde-in-

duced antinociception, effectof $-funaltrexamine on

(mice), 494Albuquerque, E. X., see Shaker,

N., 172Allison, M. E. M., see Stier, C. T.,

Jr., 366

N-Allylnormetazocine, effect onbody temperature (mice), 468

Alm-CO-CH2Br, regeneration ofbeta adrenoreceptors in heart

and lung by (rats), 247p-Aminobenzoic acid

N-acetylation in liver (rabbits),

N-acetylation in liver (ham-stem), 8

-y-Arninobutyric acid (GABA)mediation in benzodiazepine in-

hibition of Met5-enkephalin

(rats), 616metabolism, effect of valproic

acid (mice), 654

y-Aminobutyric acid agonists, an-tinociceptive effect (mice),482

-y-Aminobutyric acid receptor ag-onists

brain, anticonvulsant action, ki-netic and metabolic proper-ties and neuropharmacologi-cal profiles (mice, rats, cats),

660effects on acetylcholine turn-

over in brain (rats), 689

effect on y-aminobutyric acidreceptors in brain (rats, rab-bits, mice), 672

effects on metabolism and brainturnover of norepinephrine,dopamine and 5-hydroxy-tryptamine (rats, cats), 678

2-Aminofluorene, N-acetylation

in liver (hamsters), 8Aminoglycosides

inhibition of renal phosphati-

dylinositol phospholipase Cby (rats), 287

-induced phospholipidosis inrenal cortex (rats), 514

-induced renal failure, role ofrenin-angiotensin system in(rats), 433

ultrafiltration in vivo (rats), 604Aminopyrine, uptake, by parietal

cells (dogs), 371p-Aminosalicytic acid, N-acetyla-

tion in liver (hamsters), 8#{244}-Aminovaleric acid, effect on

acetylcholine turnover inbrain (rats), 689

Amitriptyline, alpha adrenocep-tsr antagonist potency of(rats), 299

d-Amphetamine, behavioral ef-fects, comparison with phen-cyclidine, ketamine and mor-phine (monkeys), 139

Analgesia

morphine, potentiation by y-

aminobutyric acid agonists(mice), 482

norepinephrine and serotonin,effects of 6-hydroxydopa-mine and 5,6-dihydroxytryp-tamine (rats), 311

vasopressin, characterization of(mice, rats), 329

Analog, of N-dimethylamino, an-tagonism of prostaglandinF�,,-mediated pulmonary andsystemic vasoconstriction by

(rats), 521Anderson, G. F.: Evidence for a

prostaglandin link in the pur-inergic activation of rabbitbladder smooth muscle, 347

Angiotensin I-converting enzyme,role in renal failure, inhibi-tion by captopril (rats), 433

Antagonists

alpha adrenoceptor, potency of

amitriptyline (rats), 299calmodulin, effects on contrac-

tion of aortic strips (rabbits),191

opiate, effects on body temper-

ature (mice), 464prostaglandin, effect on pulmo-

nary and systemic vascular

responses (rats), 521Anticonvulsant actions, of proga-

bide and SL 75102 (mice, rats,cats), 660

AnticonvuLsant drugs (see specificdrug)

Anticonvulsant effects, of valproicacid (mice), 654

Antigen-induced contraction of

isolated pulmonary arteries

(guinea pigs), 526Anti-inflammatory drugs

cardiovascular effects of ibu-profen (rabbits), 167

nonsteroidal, laxative potential

of (hamsters), 236Antithrombin III, affinity chro-

matography, fractionation ofheparins by (cows, hogs), 406

Aortaangiotensin converting enzyme

tissue activity, inhibition bycaptopril and MK-421 (rats),63

strips, effects of calmodulin an-

tagonists on contraction of(rabbits), 191

strips, effect of converting en-zyme inhibitors on prosta-glandin synthesis by (rats), 23

strips, effects of molsidomine(rabbits, man), 183

Aortic contraction, C5a-induced,

effect ofan antihistamine andinhibitors of arachidonatemetabolism (guinea pigs), 102

Apomorphine

and stressors, interaction inproduction of hyperthermia(rabbits), 335

-induced aggression after corn-bination with clonidine

(rats), 389

Apstein, C. S. and Vogel, W. M.:

Coronary arterial vasodilatoreffect of ibuprofen, 167

Arachidonic acid, effect on pros-taglandin production on his-

tamine-stimulated acid secre-tion in isolated parietal cells

(dogs), 371Araki, H., Su, C. and Lee, T. J.-F.:

Effect of superior cervical

ganglionectomy on the serial-

tivity of rabbit ear artery andcerebral arteries ofrabbit andcat to vasoactive agents, 49

Arbilla, S., see lloyd, K. G., 672Aronoff, G. R., see Luft, F. C., 433Arteries

ear and cerebral, effect of su-perior cervical ganglionec-tomy on sensitivity to vase-

active agents (rabbits, cats),49

isolated mesenteric and coro-nary, contractile actions ofracemic and d-propranolol(dogs), 127

pulmonary, isolated, antigen ef-fects on (guinea pigs), 526

Artery, pulmonary, effects oftheophylline on KC1-inducedpurine release from adrener-gic nerves of (rabbits), 152

Asano, M., Suzuki, Y. and Hidaka,H.: Effects ofvarious calmod-

ulin antagonists on contrac-

704 Index

tion of rabbit aortic strips,191

ATP, effect on Ca� uptake (rab-bits), 347

Atropineattenuation of antinociceptive

effect of drugs (mice), 482

role in field stimulation-in-duced contractions (rabbits),

216AY-23, 427, disposition, compari-

son in normal and arthriticsubjects (rats), 417

Backenroth, R., see Galler, M., 23Baker, S. P. and Pitha, J.: lire-

versible blockade of betaadrenoreceptors and their re-covery in the rat heart andlung in vivo, 247

Baister, R. L., see Brady, K. T., 56Barry, W. H., see Horowitz, J. D.,

488Bartholini, G., see lloyd, K. G.,

672Bartholini, G., see Scatton, B.,

678, 689

Bartholini, G., see Worms, P., 660Bashour, F. A., see Downey, H.

F., 375Bass, P., see Gullikson, G. W., 236Beaumont, K., see lloyd, K. G.,

672

Beek, D., see Kenakin, T. P., 77

Beek, D., see Kenakin, T. P., 353

Behavior

aggression, drug-induced, mod-ulation by central serotoner-gic mechanisms (rats), 389

anticonvulsant actions of pro-gabide and SL 75102 (mice,rats, cats), 660

anticonvulsant effects of val-

proic acid (mice), 654conditioned, comparison of ef-

fects of phencyclidine, keta-mine, d-arnphetamine andmorphine (monkeys), 139

discriminative stimulus andreinforcing properties of

etoxadrol and dexoxadrol(monkeys), 56

effects of adenosine analogs(mice, rats), 70

effects of methadone isomers

(pigeons), 592effects of morphine and meth-

adone (rats), 561

self-administration, cigarettesmoking (man), 256

stress, effect of apomorphine on(rabbits), 335

Bend, J. R., see Devereux, T. R.,223

Benzodiazepine

inhibition of Met5-enkephalin,y-aminobutyric acid (GABA)mediation in (rats), 616

oxidizing capacity, age-relatedchanges (man), 120

Berkowitz, B. A., see Hynes, M.D., 499

Berkowitz, B. A. and Sherman, S.:Characterization of vasopres-

sin analgesia, 329

Bhargava, H. N. and Kim, H. S.:

Structure activity relation-

ship studies with hypotha-

lamic peptide hormones. I.Effect of melanotropinrelease inhibiting factor andanalogs on tolerance to mor-

phine in the rat, 394

Bianchini, P., Osima, B., Parma,B., Nader, H. B. and Dietrich,C. P.: Pharmacological activ-ities of heparins obtainedfrom different tissues: En-richment of heparin fractionswith high lipoprotein lipase,antihemolytic and anticoag-ulant activities by molecularsieving and antithrombin Illaffinity chromatography, 406

Bigelow, G. E., see Griffiths, R.

R., 256

Binding site, of salicylate (man),648

Blackburn, P., see Tabachnik, N.

F., 243Bladder, smooth muscle, effect of

ATP on synthesis of prosta-glandins in (rabbits), 347

Bladder base, field-stimulated,pharmacology of (rabbits),216

Blood, choline in, effects of phos-phatidylcholine on (rats), 322

Blood cells, red, drug-induced he-molysis (hamsters), 236

Blood flow, renal and splanchnic,during nicotine infusion, ef-fects of alpha and of corn-bined alpha and beta adre-

nergic blockade (dogs), 375Blood pressure

diastolic, effects of prenalterol(guinea pigs, dogs), 77

effects ofcaptopril and MK-421on (rats), 63

effect of L-5-hydroxytrypto-

phan (rats), 579effect of 5-methoxy-N,N-di-

methyltryptamine (cats), 39response to vasopressin (mice,

rats), 329

Bochner, F., see Cham, B. E., 648Borneol inhibition ofvalproic acid

glucuronidation by (rats), 305

Bothwell, W., Verburg, M., Wyn-

alda, M., Daniels, E. G. andFitzpatrick, F. A.: A radioim-

munoassay for the unstablepulmonary metabolites ofprostaglandin E3 and E�: Anindirect index of their in vivodisposition and pharmacoki-netics, 229

Boyd, M. R., see Devereux, T. R.,

223Brady, K. T., Woolverton, W. L

and Baister, R. L: Discrimi-native stimulus and reinforc-ing properties of etoxadrol

and dexoxadrol in monkeys,56

Bradykinin, edema formation, in-hibition by methylpredniso-lone and diphenhydramine(dogs), 293

Brain (see also specific part)

‘y-aminobutyric acid agonists,

anticonvulsant actions, Id-netic and metabolic proper-ties and neuropharmacologi-

cal proffles (mice, rats, cats),660

-y-aminobutyric acid receptors,specificity of progabide andSL 75102 for (rats, rabbits,mice), 672

angiotensin converting enzymetissue activity, inhibition bycaptopril and MK-421 (rats),63

anticonvulsant effects of val-proic acid in (mice), 654

comparative study of effects of

ethanol on cholinergic sys-tern in (mice), 203

competition by L-a-methyldopametabolites for adrenergic re-ceptors in (rats), 552

effects of phosphatidylcholineon choline and acetylcholinein (rats), 322

effect of progabide on turnoverof norepinephrine, dopamine

and 5-hydroxytryptamine in(rats, cats), 678

monoamine oxidase, inhibition

by molindone (rats), 609

serotonin turnover rate, effect

of L-5-hydroxytryptophan

(rats), 579

striatum, -y-aminobutyric acid(GABA) mediation in benzo-diazepine inhibition of Met5-enkephalin in (rats), 616

striatum, effects of y-aminobu-tyric acid receptor agonistson acetylcholine turnover in(rats), 689

striatum, effects of morphine on

calcium-regulated phospho-rylation of synaptosomal cy-

tosolic proteins from (rats),

696

Brain stem, medullary chemosen-sitive areas, respiratory andcardiovascular effects of mor-phine, pentobarbital and na-loxine in (cats), 642

Braselton, W. E., see Smith, J. H.,540

Brewer, J. A. see Hem, D. W., 8

Briley, M., see Lloyd, K. G., 672

Bromocriptine, effects on singlenephron and whole-kidneyfunction (rats), 366

Browner, M., see Kendall, D. A.,

482

Buckner, C. K., see Hand, J. M.,526

Buprenorphineeffect on body temperature

(mice), 468effects on plasma luteinizing

hormone and prolactin inmale heroin addicts (man),252

Burimamide, antagonism of his-tamine H2-receptors in tra-

chea (rabbits), 353Butorphanol, effect on body tern-

perature (mice), 468

Byrd, L. D.: Comparison of thebehavioral effects of phency-

Vol. 220

cidine, ketamine, d-amphet-

amine and morphine in thesquirrel monkey, 139

Byrne, G., see Charn, B. E., 648

C5a-induced aortic contraction,effect ofan antihistamine andinhibitors of arachidonate

metabolism (guinea pigs), 102Ca�

calmodulin, role in phosphoryl-ation of striatal synapticmembrane proteins (rats),

278

effects of carbachol, ATP andprost.aglandin E1 on (rabbits),347

Cacini, W.: Comparative accu-mulation of uric acid and hy-poxanthine by slices of avian

renal cortex, 86

Cardiovascular function, in hypo-volemic shock, effect of nal-oxone on (dogs), 621, 625

Calciumeffect on propranolol-induced

contractions on mesenteric

and coronary arteries (dogs),127

ions, inhibition ofcalcium chan-

nels in intestinal smoothmuscle by (guinea pigs), 382

-regulated phosphorylation of

synaptosomal cytosolic pro-

teins from striatum, effects ofmorphine on (rats), 696

Calcium channels, in intestinalsmooth muscle, inhibition by

calcium ions (guinea pigs),

382

Calcium conductance, effect ofphenytoin (rats), 29

Calmodulin, antagonists, effectsOn contraction of aortic strips

(rabbits), 191Captopril

effect on prostaglandin synthe-

sis (rats), 23

inhibition of angiotensin I-con-verting enzyme in renal fail-ure (rats), 433

inhibition of angiotensin con-verting enzyme (rats), 63

Carbachol, effect on Ca� uptake(rabbits), 347

Carbamazepine, effects on potas-

sium- and veratridine-stimu-lated calcium uptake in syn-aptosomes (rats), 29

Cardiovascular effectsof ibuprofen (rabbits), 167of morphine, pentobarbital and

naloxone in brain stem (cats),642

Catecholaminescontent in ear and cerebral ar-

teries after superior cervicalganglionectomy (rabbits,cats), 49

chronotropic effects in isolated

atria as influenced by dietarylipid (rats), 340

Cayen, M. N., see Ferdinandi, E.

S., 417

Cellsheart, cultured, lack of interac-

1982

tion between digoxin andquinidine in (chicks), 488

hippocampal pyramidal, effectsof QX.314 on (guinea pigs),476

nonciliated bronchiolar epithe-lial (Clara) and alveolar typeII, isolated from lung, mets-bolic activation of 4-ipo-meanol in (rabbits), 223

renal tubular, toxic effects oforganohalide on (rats), 597

spinothalarnic tract, iiihibition

produced by stimulation innucleus raphe magnus or

periaqueductal gray, effects

of serotonin antagonists on(monkeys), 266

Cerami, A., see Tabachnik, N. F.,243

Cham, B. E., Bochner, F., Imhoff,D. M., Byrne, G. and Guns-berg, M.: In vivo and in vitrostudies on the binding of sa-licylate to human plasmaproteins: Evidence for onetype of binding site, 648

2-Chloroadenosine, behavioraland physiological effects(mice, rats), 70

Chiorpheniramine, inhibition ofhistamine H1 receptors by(rabbits), 353

Cho, A. K., see Fischer, J. B., 115Cho, C., see Raheja, K. L, 427Choleresis, by valproic acid, effect

of inducers and inhibitors ofglucuromdation on (rats), 305

Choline, in blood and brain, ef-fects of phosphatidyicholineon (rats), 322

Choline acetyltransferase, fromstriatum and hippocampus,comparative study on effectsof ethanol on (mice), 203

Christ, D., Curry, J. and Zitaglio,T.: Potentiation of the gan-gliomc blocking action of nor-epinephrine by cocaine, 97

Cigarette smoking, manipulationof number of puffs per bout,interbout interval and mco-tine dose (man), 256

Cimetidine, antagonism of hints-mine Hrreceptors in trachea(rabbits), 353

Cinanserin, antagonistic effect on

inhibition of phrenic nerveactivity by 5-methoxy-N,N-dimethyltryptamine (cats),

39Clearance, of antipyrine, age-re-

lated changes (man), 120Clearance rate, metabolic, of cir-

culating dopamine-/3-hydrox-

ylase, effect ofdiabetes (rats),108

Clonidineeffect on prostaglandin E1-aug-

mented cyclic AMP levels injejunum (rats), 637

enhancement of apormorphine-

induced aggression (rats), 389

Clouet, D. H., see Williams, N.,

278

Cobalt, ion, influence on inhibi-

tory effects of calcium ion(guinea pigs), 382

Cocaine, effect of gangliomcblocking by norepinephrine

in presence of (hamsters), 97Cochin, J., see Rosow, C. E., 464,

468

Cohen, M. L and Kui-z, K. D.:Angiotensin converting en-zyme inhibition in tissuesfrom spontaneously hyper-tensive rats after treatmentwith captopril or MK-421, 63

Commissaris, R. L., Semeyn, D.R. and Rech, R H.: Disposi-tional without functional tol-erance to the hypothermiceffects ofpentobarbital in therat, 536

Connors, B. A., see Luft, F. C., 433

Connors, B. W. and Prince, D. A.:Effects of local anestheticQX-314 on the membraneproperties of hippocampal

pyramidal neurons, 476Constantinidis, J., see Scatton, B.,

678

Contractile force, of isolated atriaand right ventricular papil-lary muscles, effects of oua-bain on (guinea pigs, rabbits,cats), 145

Contractionsof aortic strips, effects of cal-

modulin antagonists (rab-

bits), 191field stimulation-induced, ef-

fects of phenoxybenzamine,guanethidine, phentolamine

and atropine (rabbits), 216Cook, C. E., Seltzman, T. P., Tal-

lent, C. R. and Wooten, J. 13.III: Immunoassay of racemicdrugs: A problem of enantio-selective antisera and a solu-tion, 568

Cooper, S. E., see Kluwe, W. M.,

597

Corey, E. J., see Stinger, R. B.,521

Costa, E., see Harsing, L. G., Jr.,616

Covalent binding, of diethylstil-bestrol (rats), 358

Cowden, E. A., see Stier, C. T.,Jr., 366

Crystal, G. J., see Downey, H. F.,375

Cubeddu, L. X., see Hoffman, I.S., 16

Curry, J., see Christ, D., 97Cyclazocine, effect on body tern-

perature (mice), 468Cyclic AMP, dibutyryl, -induced

intestinal secretion, alpha-2adrenergic inhibition of(rats), 637

Cyclic guanosine 3’:5’-rnonophos-phate, in platelets, effects ofmethemoglobin (rabbits,man), 183

Cyclohexyladenosine, behavioraland physiological effects

(mice, rats), 70Cystic fibrosis, role of N-2-

mercaptoethyl-1 ,3-diarnino-

propane in treatment of (rab-bits, man), 243

Cytochrome P-450

-dependent drug metabolism,age-related changes (rats),574

role in metabolic activation of4-ipomeanol in nonciiatedbronchiolar epithelial (Clara)and alveolar type II cells iso-lat�d from lung (rabbits), 223

Daniels, E. G., see Bothwell, W.,229

Daniels-McQueen, S., see Ferren-

delli,J.A.,29Dantrolene sodium, effects on

electrophysiological proper-

ties of cardiac Purkinje fibers(dogs), 157

Dedek, J., see Scatton, B., 678N-Demethylation, ethylmor-

phine, in isolated hepato-cytes, kinetics of (rats), 35

De Montis, G., see Lloyd, K. G.,

672

Denervation, sympathetic, effecton sensitivity of ear and cere-bral arteries to vasoactiveagents (rabbits, cats), 49

Depoorterer, H., see Worms, P.,660

Devereux, T. R., Jones, K. G.,Bend, J. R., Fouts, J. R., Sta-tharn, C. N. and Boyd, M. R:In vitro metabolic activa-tion of the pulmonary toxin,4-iporneanol, in nonciiatedbronchiolar epithelial (Clara)and alveolar type II cells iso-lated from rabbit lung, 223

Dexoxadrol, discriminative stim-ulus and reinforcing proper-ties (monkeys), 56

Diabetes, insulin-deficient, effectson acetaminophen-inducedhepatotoxicity and metabo-lism (rats), 504

Diarrhea, drug-induced (ham-

sters), 236Diazepam

effect on apomorphine-inducedhypertherinia (rabbits), 335

effects on potassium- and verat-ridine-stimulated calcium up-take in synaptosomes (rats),29

Dibenzofuranacetic acid, disposi-tion, comparison in normaland arthritic subjects (rats),417

1,2-Dibromo-3-chloropropane, re-

lationship of tissue nonpro-tein sulihydryls to toxic ef-fects of (rats), 399

Dietary lipid, influence onchanges in accumulation ofnorepinephrine and chrono-

tropic effects of catechol-amines in isolated atria(rats), 340

Diethyl maleate, effects on gluts-thione depletion, potentia-

tion of 1,2-dibromo-3-chloro-propane toxicity (rats), 399

Diethylstilbestrol, distribution

Index 705

during pregnancy (rats), 358Dietrich, C. P., see Bianchini, P.,

406

Digoxin, lack of interaction withquinidine in heart cells(chicks), 488

[3HjDihydroalprenolol, binding inheart and lung, inhibition byAlm-CO-CH2Br (rats), 247

[3H]Dihydroxyalprenolol, specific

binding to cardiac homoge-nates, effect of isoproterenol(rats), 411

3,4-Dihydroxyphenylacetic acid,striatal, effects of molindone

(rats), 6095,6-Dihydroxytryptamine, effect

on depletion of spinal cord

norepinephrine or serotonincontent (rats), 311

Diphenhydramine

effect on C5a-induced aorticcontraction (guinea pigs), 102

inhibition of potentiation ofbradykinin edema formationby (dogs), 293

Diprenorphine, effect on bodytemperature (mice), 468

Dispositionmyocardial, of verapamil

(dogs), 91of etodolac, prodolic acid, AY-

23,427, furobufen and diben-zofuranacetic acid in normal

and arthritic subjects (rats),417

of pulmonary metabolites ofprostaglandin E1 and Ez (rab-bits, man, dogs), 229

Distribution, fetal, of diethylstil-bestrol (rats),358

Divoll, M., see Greenblatt, D. J.,

120Dopamine

in brain, effect of tryptophan(rats), 579

neurons, brain, effects of mel-indole on (rats), 609

release and metabolism, in neo-striatum, presynaptic effectsof tetrahydropapaveroline

(rabbits), 16turnover in brain and metabo-

lism, effect ofprogabide (rats,cats), 678

Dopamine-$-hydroxylase, serum,

effect of diabetes (rats), 108

Downey, H. F., Crystal, G. J. andBashour, F. A.: Regionalrenal and splanchnic bloodflows during nicotine infu-sion: Effects of alpha and ofcombined alpha and betablockade, 375

Dowrne, J. W., see Slack, B. E.,216

Drug disposition, comparison innormal and arthritic subjects(rats), 417

Drug transport, effect on kineticsOf ethylmorphine N-demeth-ylation in isolated hepato-cytes (rats), 35

Drugs, racemic, immunoassay of(rabbits), 568

Dunwiddie, T. V. and Worth, T.:

706 Index

Sedative and anticonvulsanteffects of adenosine analogsin mouse and rat, 70

Durand, A., see Worms, P., 660Durkin, T. P., Hashem-Zadeh, H.,

Mandel, P. and Ebel, A.: Acomparative study of theacute effects of ethanol onthe cholinergic system in hip-pocampus and striatuin ofinbred mouse strains, 203

Ebel, A., see Durkin, T. P., 203Echizen, H. and Freed, C. R.:

Long-term infusion of L-5-hy-

droxytryptophan increases

brain serotonin turnover anddecreases blood pressure innormotensive rats, 579

5,8,11,14-Eicosatetraynoate, inhi-

bition of C5a-induced aorticcontraction (guinea pigs), 102

Elbadawi, A., see Slack, B. E., 216Eldefrawi, A. T., see Shaker, N.,

172Eldefrawi, M. E., see Shaker, N.,

172

Electroencephalogram, effects ofmorphine and methadone(rats), 561

Electrophysiological properties,of cardiac Purkinje fibers, ef-fects ofdantrolene sodium on(dogs), 157

Elharrar, V. and Zipes, D. P.: Ef-fects of encainide and me-tabolites (MJ14030 andMJ9444) on canine cardiacPurkinje and ventricular fi-bers, 440

Ellingboe, J., see Mendelson, J.H., 252

Encainide, effects on cardiac Pur-kinje and ventricular fibers(dogs), 440

Endocrine function, and growth,

effects ofperphenazine (rats),

133

Enna, S. J., see Kendall, D. A.,482

Enzymeangiotensin converting, inhibi-

tion by captopril and MK-421(rats), 63

inhibitors, converting, effect onprostaglandin synthesis byisolated glomeruli and aorticstrips (rats), 23

renal, effect of phenobarbital(rats, rabbits), 547

Epididymis, toxic effects of 1,2-di-

bromo-3-chloropropane, roleof glutathione (rats), 399

Erickson, R R, Yu-Drent, P. andHoltzman, J. L: The kineticsof ethylmorphine N-demeth-ylation in IsOlated hepato-

cytes: The effect of drugtransport and oxygen concen-tration, 35

Ethanol, effects on cholinergicsystem in hippocampus and

striatum, comparative study(mice), 203

Ethylketocyclazocine

diuretic effects (rats� toads), 585

-induced antinociception, effectof ,8-funaltrexamine on(mice), 494

Etodolac, disposition, comparison

in normal and arthritic sub-jects (rats), 417

Etoxadrol, discriminative stimu-

lus and reinforcing properties(monkeys), 56

Evan, A. P., see Luft, F. C., 433Excretion

biiary, of valproic acid, effectof inducers and inhibitors ofglucuromdation on (rats), 305

electrolyte, effect of ethylketo-

cyclazocine (rats, toads), 585renal, of gentamicin and netil-

micin (rats), 604renal, of purines (chickens), 86renal, of water and electrolytes,

effect ofbromocriptine (rats),366

Feldman, R. D., see Goldberg, M.

R., 552

Feldman, S., see Pastoriza-Mu-

noz, E., 604Feldman, S., Wang, M.-Y. and

Kaloyanides, G. J.: Amino-glycosides induce a phospho-lipidosis in the renal cortex ofthe rat. An early manifests-tion of nephrotoxicity, 514

Ferdinandi, E. S., Cayen, M. N.and Pace-Asciak, C.: Dispo-sition of etodolac, other anti-inflammatory pyranoindole-

1-acetic acids and furobufen

in normal and adjuvant ar-thritic rats, 417

Ferrendelli, J. A. and Daniels-McQueen, S.: Comparativeactions of phenytoin andother anticonvulsant drugs

on potassium- and veratri-dine-stimulated calcium up-

take in synaptosomes, 29Field, M., see Kachur, J. F., 449,

456Fischer, J. B. and Cho, A. K.: In-

bibition of [3H]norepineph-rise uptake in organ culturedrat superior cervical gangliaby xylamine, 115

Fitzpatrick, F. A., see Bothwell,W., 229

Fitzpatrick, T. M., see Stinger, R.B., 521

Fl#{243}rez,J., see Hurl#{233},M. A., 642

[3H]Flunitrazepam, binding sites,effect of SL 75102 (rats, rab-bits, mice), 672

Folkert, V. W., see Galler, M., 23Fouts, J. R., see Devereux, T. R.,

223Freed, C. R., see Echizen, H., 579Friedman, E., see Meller, E., 609Fuller, R W., see Hahn, R A., 389

$-Funaltrexamine, pharmacology

of (mice), 494

Furobufen, disposition, compari-son in normal and arthriticsubjects (rats), 417

Galactosamine, inhibition of val-proic acid glucuronidation by

(rats), 305Galler, M., Backenroth, R., Folk-

eli, V. W. and Schlondorff,D.: Effect of converting en-zyme inhibitors on prosta-glandin synthesis by isolated

glomeruli and aortic stripsfrom rats, 23

Ganglionectomy, superior cervi-cal, effect on sensitivity of earand cerebral arteries to vase-active agents (rabbits, cats),49

Gentamicineffects on phospholipid metab-

olism of renal cortex (rats),514

inhibition of renal phosphati-dylinositol phospholipase Cby (rats), 287

nephrotoxicity, influence of an-

giotensin I-converting en-

zyme (rats), 433ultrafiltration in vivo (rats), 604

Gerber, J. G., see Skoglund, M. L.,371

Ghysel-Burton, J., see Grupp, G.,145

Glomeruli strips, effect of con-

verting enzyme inhibitors onprostaglandin synthesis by(rats), 23

Glowinski, I. B., see Hein, D. W.,

Glucuromdation, of valproic acid,effect of inducers and inhibi-tors of (rats), 305

Glutathionein liver, depletion, effects of ac-

etaminophen (rats), 504reduced, in liver, effects of pro-

pylthiouracil and triiodo-L-thyronine (rats), 427

role in toxic effects of 1,2-

dibromo- 3 -chloropropane(rats), 399

Glycogen, in liver, effects of pro-pylthiouracil and tniodo-L-

thyronine (rats), 427Godfraind, T., see Grupp, G., 145

Goldberg, L. I., see Rajfer, S. I.,127

Goldberg, M. R, Twig, C.-S.,Feldman, R. D., Smith, H. E.,

Oates, J. A. and Robertson,D.: Differential competitionby L-a-methyldopa metabo-lites for adrenergic receptorsin rat forebrain, 552

Greeley, G. H., Jr., Lipton, M. A.and Kizer, J. S.: Effects ofchronic perphenazine treat-ment on growth and endo-crine function in developingrats, 133

Greenblatt, D. J., Divoll, M.,Abernethy, D. R., Harmatz,J. S. and Shader, R. I.: Anti-pyrine kinetics in the elderly:Prediction of age-relatedchanges in benzodiazepineoxidizing capacity, 120

Greenwell, A., see Kiuwe, W. M.,

399

Gregar, G. J., see Prasad, C. M.,293

Vol. 220

Griffiths, R. R., Henningfield, J.

E. and Bigelow, G. E.: Hu-man cigarette smoking: Ma-nipulation of number of puffsper bout, interbout intervaland nicotine dose, 256

Growth, and endocrine function,effects ofperphenazine (rats),133

Grupp, G., Grupp, I. L., Ghysel-Burton, J., Godfraind, T. andSchwartz, A.: Effects of very

low concentrations of oua-bain or contractile force ofisolated guinea-pig, rabbitand cat atria and right yen-tricular papifiary muscles: Aninterinstitutional study, 145

Grupp, I. L, see Grupp, G., 145

Guanethidine, role in field stimu-lation-induced contractions(rabbits), 216

Guanylate cyclase, stimulation bymolsidomine (rabbits, man),183

Gullikson, G. W., Sender, M. andBass, P.: Laxative-like effects

of nonsteroidal anti-inflam-matory drugs on intestinalfluid movement and mem-

brane integrity, 236Gunsberg, M., see Cham, B. E.,

648Guril, N. J., Reynolds, D. G., Var-

gish, T. and Lechner, R.: Nal-ozone without transfusionprolongs survival and en-

hances cardiovascular func-tion in hypovolemic shock,621

Gull, N. J., Reynolds, D. G., Var-gish, T. and Lechner, R.: Nal-trexone improves survivalrate and cardiovascular func-tion in canine hemorrhagicshock, 625

Hahn, R. A., Hynes, M. D. andFuller, R W.: Apomorphine-induced aggression in ratschronically treated with oralclonidine: Modulation bycentral serotonergic mecha-nisms, 389

Haloperidol, effect on apomor-

phine-induced hyperthermia(rabbits), 335

Hand, J. M., Will, J. A. and Buck-ner, C. K.: Pharmacologicalalteration of antigen-inducedcontraction of pulmonary ar-teries isolated from the ac-tively sensitized guinea pig,526

Harmatz, J. S., see Greenblatt, D.J., 120

Harrington, F., see Kluwe, W. M.,399

Harrington, F. W., see Kiuwe, W.M., 597

Harsing, L G., Jr., Yang, H.-Y. T.and Costs, E.: Evidence for a-y-arninobutyric acid (GABA)mediation in the benzodiaze-pine inhibition of the releaseof Met5-enkephalin elicited

672

Index 7071982

by depolarization, 616Hashem-Zadeh, H., see Durkin,

T. P., 203

Heartangiotensin converting enzyme

tissue activity, inhibition bycaptopril and MK-421 (rats),63

cells, cultured, lack of interac-tion between digoxin andquirndine in (chicks), 488

effects of isoproterenol on ace-tylcholine and beta receptorsin isolated atria (rats), 411

influence by dietary lipid on ac-cumulation of norepineph-rime and chronotropic effectsof catecholamines in (rats),340

irreversible blockade and recov-

ery of beta adrenoreceptors

in (rats), 247

isolated, perfused, vasodilation

by ibuprofen in (rabbits), 167maturation of sympathetic neu-

rotransmission in (rats), 629

postjunctional supersensitivityproduced by immunologicaland chemical sympathec-tomy in (rats), 209

Purkinje and ventricular fibers,

effects of encainide and me-

tabolites on (dogs), 440

Purkinje fibers, effects of dan-trolene sodium on electro-physiological properties of

(dogs), 157Heart failure, congestive, use of

prenalterol in (guinea pigs,dogs), 77

Heart strips, isolated, effects ofouabain on contractile force

of (guinea pigs, rabbits, cats),

145Heckmann, M. E., see Miller, R.

K., 358

Hem, D. W., Hirata, M., Glowin-ski, I. B. and Weber, W. W.:Biochemical evidence for the

coexistence of monomorphicand polymorphic N-acetyl-

transferase activities on acommon protein in rabbitliver, 1

Hem, D. W., Omichinski, J. G.,Brewer, J. A. and Weber, W.W.: A unique pharmacoge-netic expression of the N-ace-

tylation polymorphism in theinbred hamster, 8

Henningfield, J. E., see Griffiths,R. R., 256

Heparins, from different tissues,pharmacological activities of(cows, hogs), 406

Hepatocyte, isolated, kinetics of

ethylmorphine N-demethyl-

ation in (rats), 35Hepatotoxicity, acetaminophen-

induced, effects of insulin-de-ficient diabetes on (rats), 504

Heroin addicts, male, buprenor-phine effects on plasma lu-teinizing hormone and pro-lactin in (man), 252

Hidaka, H., see Asano, M., 191

Hidaka, H., see Nishikawa, M.,183

Hippocampus, effects of ethanolon cholinergic system in(mice), 203

Hirats, M., see Hein, D. W., 1Histamine

effect on C5a-induced aorticcontraction (guinea pigs), 102

effects on isolated pulmonaryarteries (guinea pigs), 526

effect of superior cervical gan-glionectomy on sensitivity ofear and cerebral arteries to

(rabbits, cats), 49H2-recepthr-mediated relaxa-

tion of trachea (rabbits), 353Hoffman, I. S. and Cubeddu, L.

X.: Presynaptic effects oftetrahydropapaverdine onstriatal dopaminergic neu-rons, 16

Holtzman, J. L, see Erickson, R.R., 35

Homovanillic acid, striatal, effects

of molindone (rats), 609Hook, J. B., see Kuo, C-H., 547

Hook, J. B., see Smith, J. H., 540

Horita, A., see Snow, A. E., 335

Hormones (see also specific

names)peptide, hypothalamic, struc-

ture activity relationshipstudies with (rats), 394

Horowitz, J. D., Barry, W. H. andSmith, T. W.: Lack of inter-action between digoxin and

qumidine in cultured heartcells, 488

Howe, J. R. and Yaksh, T. L.:Changes in sensitivity to in-trathecal norepinephrine andserotonin after 6-hydroxydo-

pamine (6-OHDA), 5,6-dihy-droxytryptamine (5,6-DHT)or repeated monoamine ad-ministration, 311

Hurl#{233},M. A., Mediavilla, A. andFl#{243}rez,J.: Morphine, pento-barbital and naloxone in theventral medullary chemosen-sitive areas: Differential re-spiratory and cardiovasculareffects, 642

Hurst, J. H., Nisula, B. C. andStolk, J. M.: Circulating do-pamine-fl-hydroxylase in therat: Importance of altereddisposal pathways in experi-mental diabetes, 108

Hurwitz, L., McGuffee, L. J.,Smith, P. M. and Little, S. A.:

Specific inhibition of calciumchannels by calcium ions insmooth muscle, 382

Hydrochlorothiazide, natriuretic

effect, influence of dietary

potassium on (rats), 1786-Hydroxydopamine

effect on depletion of spinalcord norepinephrine or sero-tonin content (rats), 311

role in postjunctional supersen-sitivity in heart produced byimmunological and chemicalsympathectomy (rats), 209

5-Hydroxytryptamine (see aLsoSerotonin)

turnover in brain and metabo-ham, effect ofprogabide (rats,cats), 678

L-5-Hydroxytryptophan, effect onbrain serotonin turnover andblood pressure (rats), 579

Hynes, M. D. and Berkowitz, B.A.: Lack of an opiate re-sponse to nitrous oxide inmice resistant to the activity-stimulating effects of mor-

phine, 499

Hynes, M. D., see Hahn, R A.,

389

Hyperthermia, interaction of apo-morphine and stressors in

production of (rabbits), 335

Hypotension, effect of 5-methoxy-N,N-dimethyltryptamine(cats), 39

Hypothermiaeffect of adenosine analogs

(mice, rats), 70pentobarbital-induced, disposi-

tional and functional changes

for tolerance to (rats), 536

Hypothyroidism, neonatal, effecton maturation of sympa-thetic neurotransmission inheart (rats), 629

Hypoxanthine, accumulation byrenal cortex slices, compari-

son with uric acid (chickens),86

Hysteresis effect, role of verapa-mil (dogs), 91

Ibuprofen, coronary arterial vas-odilator effect of (rabbits),167

Ileumeffect of bombesin on potential

difference and short-circuitcurrent in (rats, guinea pigs),

449

effect of neurotensin and sub-stance P on potential differ-ence and short-circuit cur-rent in (rats, guinea pigs), 456

Imhoff, D. M., see Cham, B. E.,

648

Immunoassay, of racemic drugs(rabbits),568

Insulin, effect on serum dopa-

mine-$-hydroxylase activity

(rats), 108

Intestine, small, dose-related in-hibition of fluid transport bynonsteroidal anti-inflamma-

tory drugs in (hamsters), 2364-Ipomeanol, metabolic activa-

tion in nondiiated bronchio-lar epithelial (Clara) and al-veolar type II cells isolated

from lung (rabbits), 223J.shii, K., Shigenobu, K. and Ka-

suya, Y.: Postjunctional su-persensitivity in young ratheart produced by immuno-logical and chemical sympa-thectomy, 209

[3H]Isoguvacine, binding sites, ef-fects of progabide and SL75102 (rats, rabbits, mice),

IsoniazidN-acetylation in liver (rabbits),

N-acetylation in liver (ham-sters), 8

Isoproterenol

chronotropic effects in isolated

atria as influenced by dietarylipid (rats), 340

effects on acetylcholine andbeta receptors in isOlatedatria (rats), 411

inhibition of edema by (dogs),

293role in postjunctional supersen-

sitivity in heart produced byimmunological and chemicalsympathectomy (rats), 209

Jalife,J.,seeSalata,J.J., 157Jejunum, alpha-2 adrenergic in-

hibition of intestinal secre-tion induced by prostaglan-din E,, vasoactive intestinalpeptide and dibutyryl cyclicAMP in (rats), 637

Jollow, D. J., see Price, V. F., 504Jones, K. G., see Devereux, T. R.,

223Jope, R. S.: Effects of phosphati-

dylcholine administration torats on choline in blood andcholine and acetylcholine inbrain, 322

Juskevich, J. C., see O’Callaghan,

J. P., 696

Kachur, J. F., Miller, R J. andField, M.: Neurohumoralcontrol of heal electrolytetransport. I. Bombesin andrelated peptides, 449

Kachur, J. F., Miller, R. J. andField, M.: Neurohumoralcontrol of ileal electrolytetransport. II. Neurotensinand substance P, 456

Kajiyama, H., see Nomura, Y.,411

Kaloyanides, G. J., see Feldman,

S., 514

Kaloyanides, G. J., see Pastoriza-

Munoz, E., 604Kanamori, M., see Nishikawa, M.,

183

Kasuya, Y., see Ishii, K., 209Kates, R. E., see Keefe, D. L., 91

Kato, R, see Nakak� T., 637

Katsuragi, T. and Su, C.: Aug-mentation by theophylline of[3Hlpurine release from vas-cular adrenergic nerves: Evi-dence for presynaptic auto-

inhibition, 152

Keefe, D. L. and Kates, R. E.:Myocardial disposition and

cardiac pharmacodynamicaof verapamil in the dog, 91

Kenakin, T. P. and Beek, D.: Aquantitative analysis of his-

tamine H2-receptor-mediatedrelaxation of rabbit trachea,

353Kenakin, T. P. and Beek, D.: In

vitro studies on the cardiac

708 Index Vol. 220

activity of prenalterol withreference to use in congestive

heart failure, 77

Kendall, D. A., Browner, M. andEnna, S. J.: Comparison ofthe antinociceptive effect ofy-aminobutyric acid (GABA)agonists: Evidence for a cho-linergic involvement, 482

Ketamine, behavioral effects,comparison with phencyci-dine, d-amphetamine andmorphine (monkeys), 139

Ketocyclazocine, effect on bodytemperature (mice), 468

Khazan, N., see Lukas, S. E., 561

Kidneyaminoglycosides induce a phos-

pholipidosis in cortex of

(rats), 514

angiotensin converting enzymetissue activity, inhibition bycaptopril and MK-421 (rats),63

blood flow during nicotine in-fusion, effects of alpha and ofcombined alpha and beta ad-renergic blockade (dogs), 375

clearance of gentamicin and ne-tilmicin (rats), 604

cortex, accumulation of pheno-barbital (rats, rabbits), 547

effects of vanadate on organic

ion accumulation in (rats),540

failure, aminoglycoside-in-

duced, role of renin-angioten-sin system in (rats), 433

monoamine oxidase, inhibition

by molindone (rats), 609phosphatidylinositol phospho-

lipase C, aminoglycoside in-hibition of (rats), 287

toxic effects of 1,2-dibromo-3-chioropropane, role of gluts-thione (rats), 399

tubular cells, toxic effects of or-ganohalide on (rats), 597

whole, effects of bromocriptine(rats), 366

Kim, H. S., see Bhargava, H. N.,394

Kinetics (see also Pharmacoki-netics)

and dynamics of verapamil(dogs), 91

ofantipyrine (man), 120

of choline uptake, effects ofethanol (mice), 203

of ethyhnorphine N-demethyl-ation in IsOlated hepatocytes,effect of drug transport andoxygen concentration (rats),35

Kizer, J. S., see Greeley, G. H.,Jr., 133

Klaassen, C. D., see Watkins, J.B., 305

Kleit, S. A., see Luft, F. C., 433Kluwe, W. M., Greenwell, A. and

Harrington, F.: Relationship

of tissue nonprotein sulfhy-dryls to the acute toxic effectsof 1,2-dibromo-3-chloropro-pane, 399

Kluwe, W. M., Harrington, F. W.

and Cooper, S. E.: Toxic ef-fects of organohalide corn-pounds on renal tubular cellsin vivo and in vitro, 597

Kohli, J. D., see Rajfer, S. I., 127

Kojic amine, antinociceptive ef-fect (mice), 482

Kot, P. A., see Stinger, R. B., 521Kuehnle, J., see Mendelson, J. H.,

252

Kuo, C-H., Rush, G. F. and Hook,J. B.: Renal cortical accumu-lation of phenobarbital inrats and rabbits: Lack of cor-relation with induction ofrenal microsomal monooxy-genases, 547

Kui-z, K. D., see Cohen, M. L., 63

Lalley, P. M.: Inhibition of

phrenic and sympathetic va-somotor neurons in cats by

the serotonin analog 5-methoxy- N ,N-dirnethyl-tryptamine, 39

Langer, S. Z., see lloyd, K. G., 672Lau, C. and Slotkin, T. A.: Matu-

ration of sympathetic neuro-transmission in the rat heart.VIII. Slowed development ofnoradrenergic synapses re-suiting from hypothyroidism,

629

Leander, J. D. and McCleary, P.E.: Opioid and nonopioid be-havioral effects of methadoneisomers, 592

Lechner, R., see GurU, N. J., 621,625

Lee, T. J.-F., see Asahi, H., 49Leighton, H. J.: Quantitative as-

sessment of the pre- andpostsynaptic alpha adreno-

ceptor antagonist potency ofamitriptyline, 299

Levallorphan, effect on body tern-perature (mice), 468

Lidocaine, effects on potassium-and veratridine-stimulatedcalcium uptake in synapto-somes (rats), 29

Lietman, P. S., see Lipsky, J. J.,287

Linseheer, W. G., see Raheja, K.L., 427

Lipoprotein lipase, high, enrich-ment of heparin fractionswith (cows, hogs), 406

Lipsky, J. J. and Lietman, P. 5.:Aminoglycoside inhibition of

a renal phosphatidylinositolphospholipase C, 287

Lipton, M. A., see Greeley, G. H.,Jr., 133

Little, S. A., see HUrWitZ, L, 382

LiverN-acetyltransferase, genetic

variation (hamsters), 8age-related changes on micro-

somal monooxygenase sys-tern from (rats), 574

evidence for coexistance ofmonomorphic and poly-morphic N-acetyltransferase

activities on protein in (rab-bits), 1

toxic effects of 1,2-dibromo-3-chloropropane, role of gluts-

thione (rats), 399lloyd, K. G., Arbilla, S., Beau-

mont, K., Briley, M., DeMontis, G., Scatton, B., Lan-ger, S. Z. and Bartholini,G.: y-Aminobutyric acid(GABA) receptor stimula-

tion. II. Specificity of proga-bide (SL 76002) and SL 75102for the GABA receptor, 672

Uoyd, K. G., see Scatton, B., 678lloyd, K. G., see Worms, P., 660Locomotor activity, effects of pro-

gabide and SL 75102 (mice,rats, cats), 660

Ldscher, W., see Nau, H., 654Lovenberg, W., see O’Cailaghan,

J. P., 696

Ludens, J. H., see Slizgi, G. R.,

585

Luft, F. C., Aronoff, G. R., Evan,A. P., Connors, B. A., Wein-berger, M. H. and Kieit, S. A.:The renin-angiotensin sys-tern in aminoglycoside-in-duced acute renal failure, 433

Lukas, S. E., Moreton, J. E. andKhazan, N.: Differentialelectroencephalographic and

behavioral cross-tolerance to

morphine and methadone inthe t-a-acetylmethadol(LAAM)-maintained rat,561

Lungangiotensin converting enzyme

tissue activity, inhibition by

captopril and MK-421 (rats),63

irreversible blockade and recov-ery of beta adrenoreceptors

in (rats), 247isolated arteries, antigen effects

on (guinea pigs), 526metabolic activation of 4-ipo-

rneanol in nondiliated bron-chiolar epithelial (Clara) andalveolar type II cells isolatedfrom (rabbits), 223

vascular responses to prosts-glandin F�,,, antagonism byN-dimethylamino analog

(rats), 521Luteinizing hormone, plasma, in

male heroin addicts, bupren-orphine effects on (man), 252

Mahany, D., see Raheja, K. L,427

Mandel, P., see Durkin, T. P., 203Mayor, G. H.. see Smith, J. H.,

540

McCleary, P. E., see Leander, J.D., 592

McGuffie, L J., see HUrWitZ, L,382

McKenzie, R C., see Miller, R.

K., 358Mediavilla, A., see Hurl#{233},M. A.,

642Melanotropin release inhibiting

factorand analogs, effect on tolerance

to morphine (rats), 394

Pro-Leu-Gly-NH2, effect on tol-

erance to morphine (rats),

394

Meller, E. and Friedman, E.: Dif-ferential dose- and time-de-

pendent effects of molindone

on dopamine neurons of rat

brain: Mediation by irrevers-ible inhibition of monoamineoxidase, 609

Mello, N. K., see Mendelson, J.H., 252

Mendelson, J. H., Ellingboe, J.,Mello, N. K. and Kuehnie, J.:Buprenorphine effects on

plasma luteinizing hormoneand prolactin in male heroinaddicts, 252

N-2-Mercaptoethyl- 1,3-diamino-propane, protein binding viamixed disulfide formation

after oral administration of

WR 2721 (rabbits, man), 243

Metabolism

arachidonate, role in C5a-in-

duced contraction (guinea

pigs), 102drug, age-related changes

(man), 120drug, effect of pentobarbital

(rats), 536

drug, hepatic microsomal, age-related changes (rats), 574

myoes.rdial oxidative, effect ofibuprofen (rabbits), 167

of acetaminophen, effects of in-

sulin-deficient diabetes on(rats), 504

of diethylstilbestol (rats), 358

of 4-ipomeanol in nonciliatedbronchiolar epithelial (Clara)

and alveolar type II cells iso-lated from lung (rabbits), 223

of norepinephrine, dopamine

and 5-hydroxytryptamine, ef-

fect of progabide (rats, cats),678

ofphospholipids ofrenal cortex,

effects of gentamicin and ne-

tilmicin on (rats), 514renal, role of uric acid and hy-

poxanthine (chickens), 86Metabolites

brain, anticonvulsant effects

(mice), 654

L-a-rnethyldOpa, competitionfor adrenergic receptors inforebrain (rats), 552

pulmonary, of prostaglandin E,and E2, radioimmunoassayfor (rabbits, man, dogs), 229

Met5-enkephalin, in striaturn, in-hibition by benzodiazepine,mediation by -y-aminobutyricacid (GABA) (rats), 616

Methadoneand morphine, cross-tolerance

in t-a-acetylmethadol-main-

tained subjects to (rats), 561

isomers, opioid and nonopioid

behavioral effects of (pi-geons), 592

5-Methoxy-N, N-dimethyltrypt-amine, inhibition of phrenicand sympathetic vasomotor

1982 Index 709

neurons by (cats), 393-Methylcholanthrene, effect on

valproic acid glucuromdation(rats), 305

L-a-MethyldOpa, metabolites,competition for adrenergicreceptors in forebrain (rats),552

Methyiprednisolone, inhibition of

potentiation of bradykinin

edema formation by (dogs),293

Methylxanthines, antagonism ofadenosine (mice, rats), 70

Metiamide, antagonism of hints-

mine H2-receptors in trachea(rabbits), 353

Microsomal monooxygenases,renal, induction by phenobar-bital (rats, rabbits), 547

Miller, J. M., see Rosow, C. E.,464, 468

Miller, R. J., see Kachur, J. F.,449, 456

Miller, R. K., Heckrnann, M. E.

and McKenzie, R C.: Dieth-ylstilbestrol: Placental tram-

fer, metabolism, covalentbinding and fetal distributionin the Wistar rat, 358

MJ9444, metsbolite, effect on car-diac Purkinje and ventricularfibers (dogs), 440

MJ 14030, metabolite, effect on

cardiac Purkinje and ventric-ular fibers (dogs), 440

MK-421, inhibition of angiotensin

converting enzyme (rats), 63Molindone, effects on dopamine

neurons of brain (rats), 609Molsidomine, inhibition of plate-

Let aggregation and stimula-tion of guanylate cyclase by(rabbits, man), 183

Monoamine oxidase, brain andkidney, inhibition by molin-

done (rats), 609Monooxygenase activities, in

liver, age-related changes(rats), 574

Moreton, J. E., see Lukas, S. E.,

561

Morphineactivity-stimulating effects,

lack of an opiate response tonitrous oxide in subjects re-sistant to (mice), 499

and methadone, cross-tolerancein t-a-acetyhnethadol-main-tamed subjects to (rats), 561

behavioral effects, comparisonwith phencyclidine, ketamine

and d-amphetsmine (mon-keys), 139

effects on calcium-regulatedphosphorylation of synapto-somal cytosoic proteins from

striaturn (rats), 696

effect of melanotropin releaseinhibiting factor and analogson tolerance to (rats), 394

effect on body temperature(mice), 464

-induced antinociception, effectof /J-funaltrexamine on(mice), 494

respiratory and cardiovasculareffects (cats), 642

Morseffi, P. L, see Worms, P., 660[3H]Muscimol

binding sites, effects of proga-bide and SL 75102 (rats, rab-bits, mice), 672

effect on acetylcholine turnoverin brain (rats), 689

Muscleanococcygeus, postsynaptic at-

pha adrenoceptor blockingaffinity of amitriptyline in(rats), 299

papillary, right ventricular, ef-fects of ouabain on contrac-

tile force of (guinea pigs, rab-bits, cats), 145

smooth, bladder, effect of ATPon synthesis of prostaglan-dins in (rabbits), 347

smooth, intestinal, inhibition ofcalcium channels by calcium

ions in (guinea pigs), 382

smooth, isolated, C5a-inducedaortic contraction (guineapigs), 102

smooth, vascular, calciumfluxes in, association of pro-pranolol-induced contrac-tions in mesenteric arteries(dogs), 127

smooth, vascular, contraction,effects of calmodulin antago-nists (rabbits), 191

Muscle tone, effects of progabide

and SL 75102 (mice, rats,

cats), 660

Nader, H. B., see Bianchini, P.,406

Nakadate, T., see Nakaki, T., 637Nakaki, T., Nakadate, T., Yams-

moto, S. and Kate, R: Alpha-2 adrenergic inhibition of in-testinal secretion induced byprostaglandin E1, vasoactive

intestinal peptide and dibu-tyryl cyclic AMP in rat jeju-nurn, 637

Nalbuphine, effect on body tern-perature (mice), 468

Nalorphine, effect on body tern-

perature (mice), 468

Naloxoneantagonism of $-funaltrexam-

me by (mice), 494effect on body temperature

(mice), 464

effect on cardiovascular func-tion in hypovolemic shock(dogs), 621, 625

respiratory and cardiovasculareffects (cats), 642

Naltrexoneeffect on body temperature

(mice), 464effect on diuretic activity of

ethylketocyclazocine (rats,toads), 585

effect on vasopressin analgesia(mice, rats), 329

Narcoticeffects on phosphorylation of

striatal synaptic membrane

proteins (rats), 278

Nau, H. and Ldscher, W.: Valproicacid: Brain and plasma levels

of the drug and its metabo-lites, anticonvulsant effects

and ‘y-aminobutyric acid(GABA) metabolism in themouse, 654

Neomycin, inhibition of renalphosphatidylinositol phos-

phoipase C by (rats), 287Nephron, single, effects of bro-

mocriptine (rats), 366Nephrotoxicity

of aminoglycosides in renal cor-

tex (rats), 514

of gentamicin, influence of an-giotensin I-converting en-zyme (rats), 433

of organohalide (rats), 597Nerves

adrenergic, vascular, KC1-in-duced purine release from, ef-fects of theophylline (rab-

bits), 152adrenergic, in field-stimulated

bladder base, functional sig-nificance (rabbits), 216

Nervous systemcentral, depressants, effect on

tolerance (rats), 536central, neurons, effect of QX-

314 (guinea pigs), 476

sympathetic, in heart, matura-

tion of (rats), 629

Netilmicineffects on phospholipid metab-

olism of renal cortex (rats),514

ultrafiltration in vivo (rats), 604

Neuroleptics, effect on striatal

acetylcholine transmission(rats), 197

Neuronscentral nervous system, effect

of QX-314 on (guinea pigs),476

central serotonergic, role in

apomorphine-induced ag-gression after combination

with clomdine (rats), 389

dopamine, brain, effects of mol-indone on (rats), 609

norepinephrine, dopamine and5-hydroxytryptamine, inbrain, effect of progabide

(rats, cats), 678

phrenic and vasomotor, inhibi-tion by 5-rnethoxy-N,N-di-

rnethyltryptamine (cats), 39striatal, dopamine-containing,

presynaptic effects of tetra-hydropapaveroline (rabbits),16

Neuropharmacological profiles, ofprogabide and SL 75102(mice, rats, cats), 660

Neurotensin, effect on potentialdifference and short-circuitcurrent in ileum (rats, guineapigs), 449, 456

Neurotransmissionadrenergic, choinergic, field

stimulation (rabbits), 216sympathetic, maturation in

heart (rats), 629Nicotine

dose, manipulation in cigarettesmoking (man), 256

infusion, effects of alpha and ofcombined alpha and beta ad-renergic blockade on bloodflow during (dogs), 375

Nies, A. S., see Skoglund, M. L,371

Nipecotic acid, antinociceptive ef-fect (mice), 482

Nishikawa, M., Kanamori, M. andHidaka, H.: Inhibition ofplatelet aggregation andstimulation of guanylate cy-clase by an antianginal agentmolsidomine and its metabo-ites, 183

Nisula, B. C., see Hurst, J. H., 108

Nitrous oxide, in subjects resist-ant to activity-stimulating ef-

fects ofmorphine, lack of opi-ate response to (mice), 499

Nomura, Y., Kajiyama, H. and

Segawa, T.: Alteration in sen-sitivity to isoproterenol andacetylcholine in the rat heartafter repeated administrationof isoproterenol, 411

Norepinephrine

changes in accumulation in iso-lated atria as influenced bydietary lipid (rats), 340

Norepinephrine

effect of superior cervical gan-glionectomy on sensitivity ofear and cerebral arteries to(rabbits, cats), 49

in brain, effect of tryptophan

(rats), 579in spinal cord, effects of 6-hy-

droxydopamine and 5,6-di-hydroxytryptamine on deple-tion of (rats), 311

potentiation of gangionicblocking action of (hamsters),

97

release from anococcygeusmuscle pretreated with co-

caine, effect of amitryptylineon (rats), 299

role in postjunctional supersen-sitivity in heart produced byimmunological and chemicalsympathectomy (rats), 209

turnover in brain and metabo-11am, effect ofprogabide (rats,cats), 678

uptake in superior cervical gan-glia, inhibition by xylamine(rats), 115

Notley, B. A., see Rikans, L. E.,574

Oates, J. A., see Goldberg, M. R.,552

O’Callaghan, J. P., Juskevich, J.C. and Lovenberg, W.: Theeffects of morphine on cal-cium-regulated phosphoryla-don of synaptosomal cyto-soic proteins from rat stria-turn, 696

Olesen, 0. V.: Influence of the di-etary potassium intake on thenatriuretic effect of hydroch-lorothiazide in rats, 178

Omichinaki, J. G., see Hein, D.

710 IndexVol. 220

W., 8Opiates

agonist-antagomit (buprenor.

phine), effect on plasma luteinizing hormone and pro-lactin in male heroin addicts(man), 252

effects on body temperature(mice), 464, 468

effects on calcium-regulatedphosphorylation of proteinfrom striatum (rats), 696

Opiate response, to nitrous oxide

in subjects resistant to activ-ity-stimulating effects of

morphine, lack of (mice), 499Opioids, tolerance and cross-tel-

erance effects in t-a-acetyl-rnethadol-rnaintajned sub-jects (rats), 561

Opioid peptides, effect on phos-phorylation of striatal syn-

aptic membrane proteins(rats), 278

Organ culture, ofsuperior cervicalganglia, inhibition of norepi-nephrine uptake by xylaminein (rats), 115

Organohalide, toxic effects onrenal tubular cells in vivo andin vitro (rats), 597

Ornithine decarboxylase, activityin cardiac tissues, isoprotere-

nol-induced stimulation of(rats), 411

Osima, B., see Bianchini, P., 406Ouabain, effects on contractile

force of isolated atria andright ventricular papillaryrnuscles (guinea pigs, rabbits,cats), 145

Ovalbumin, effects on isOlatedpulmonary arteries (guineapigs), 526

Oxygen transport, effect on kinet-

ics of ethylmorphine N-de-methylation in isolated he-patocytes (rats), 35

Pace-Asciak, C., see Ferdinandi,E. S., 417

Parma, B., see Bianchini, P., 406Pastoriza-Munoz, E., Timmer-

man, D., Feldman, S. and Ka-loyanides, G. J.: Ultrafiltra-

tion of gentamicin and netil-micin in vivo, 604

Pentazocine, effect on body tern-perature (mice), 468

Pentobarbjtajdispositional and functional

changes for tolerance to hy-pothermic effects of (rats),536

respiratory and cardiovasculareffects (cats), 642

Peptide, intestinal, vasoactive,-induced intestinal secretion,

alpha-2 adrenergic inhibition

of (rats), 637[3H]Perhydrohistrionicotoxin,

binding, inhibition by d-tub-Ocurarine (frogs), 172

Periaqueductal gray, effects ofserotonin on inhibition of spi-nothalamic tract cells pro-

duced by stimulation in(monkeys), 266

Perphenazine, effects on growthand endocrine function (rats),133

Peterson, C. M., see Tabachnik,N. F., 243

Pharmacodynarmes, cardiac, ofverapamil (dogs), 91

Pharmacokinetics

of choline in blood (rats), 322of pulmonary metabolites of

prostaglandin E1 and E2 (rab-bits, man, dogs), 229

Phencycidinebehavioral effects, comparison

with ketarnine, d-amphet-amine and morphine (rnon-keys), 139

comparison of discriminativestimulus and reinforcingproperties of etoxadrol anddexoxadrol with (monkeys),56

Phenobarbjtaj

accumulation in renal cortex,induction of renal micro-sornal rnonooxygenases (rats,rabbits), 547

effect on valproic acid glucu-ronidation (rats), 305

effects on potassium- and verat-ridine-stiniujated calcium up-take in synaptosomes (rats),29

Phenoxybenzamjne, role in fieldstimulation-induced contrac-tions (rabbits), 216

Phentolamineeffect of ganglionic blocking by

norepinephrjne in presenceof (hamsters), 97

role in field stimulation-in-duced contractions (rabbits),216

Phenylephrine, role in postjunc-tional supersensitivity inheart produced by iinmuno-logical and chemical sympa-thectorny (rats), 209

L-Phenylisopropyladen�ine, be-

havioral and physiological ef-fects (mice, rats), 70

Phenytoin, effects on potassium-and veratridine-stimulatedcalcium uptake in synapto-sornes (rats), 29

Phosphatidylcholine, effects oncholine in blood and cholineand acetylcholine in brain(rats), 322

Phosphatidylinositol phospholi-

pam C, renal, aminoglycosideinhibition (rats), 287

Phospholipids, from renal cortexand liver, effects of gentami-cin and netilmicin on (rats),514

Phosphorylation

of striatal synaptic membraneproteins, effect of opioid

drugs on (rats), 278of synaptosomal cytosolic pro-

teins from striatum, calcium-

regulated, effects of mor-phine on (rats), 696

Pitha, J., see Baker, S. P., 247Placental transfer, of diethylstil-

bestrol (rats), 358Plasma proteins, in vivo and in

vitro studies on binding of sa-licylate to (man), 648

Platelet aggregation, inhibition byrnolsidornine (rabbits, man),183

Portoghese, P. 5., see Ward, S. J.,

494

Potassium

effect of superior cervical gan-

glionecto�ny on sensitivity of

ear and cerebral arteries to(rabbits, cats), 49

intake, dietary, influence on na-

triuretic effect of hydrochio-rothiazide (rats), 178

Potentialsaction, in ganglion, blocking ef-

fect of norepinephrjne (ham-

sters), 97action, slow response, in cardiac

Purkinje fibers, effects of

dantrolene sodium (dogs),

157Potential difference

in ileum, effect ofbombesin andrelated peptides on (rats,guinea pigs), 449

in ileum, effect of neurotensinand substance P on (rats,guinea pigs), 456

Poulsen-Burke, J., see Rosow, C.E., 464,468

Prasad, C. M., Adamski, S. W.,Svensjd, E. and Grega, G. J.:Pharmacological rnodifica-

tion of the edema produced

by combined infusions of

prostaglandin E1 and brady-kinin in canine forelimbs, 293

Prenalterol, cardiac activity, usein congestive heart failure(guinea pigs, dogs), 77

Price, V. F. and Jollow, D. J.: In-

creased resistance of diabetic

rats to acetaminophen-in-

duced hepatotoxicity, 504Prince, D. A., see Connors, B. W.,

476Procaine, effect on ganglionic

blocking action of norepi-nephrine (hamsters), 97

Procainamide, N-acetylation inliver (hamsters), 8

Prodoic acid, disposition, corn-

parison in normal and ar-thritic subjects (rats), 417

Progabide (SL 76002)anticonvulsant actions, kinetic

and metabolic properties andneuropharmacological pro-

files (mice, rats, cats), 660effect on acetylcholine turnover

in brain (rats), 689

effect on turnover in brain andmetabolism of norepineph-

rime, dopamine and 5-hy-droxytryptamine (rats, cats),678

specificity for y-aminobutyric

acid receptor in brain (rats,rabbits, mice), 672

Prolactin, in male heroin addicts,

buprenorphine effects on

(man), 252Propranolol

d- and racemic, contractile ac-tions in mesenteric and coro-nary arteries (dogs), 127

effect of ganglionic blocking by

norepinephrine in presenceof (hamsters), 97

Propylthiouracil-induced hypo-thyroidism, effect on acet-aminophen toxicity (rats),

427

Prostaglandinbiosynthesis, effect of pyranoin-

dole-i-acetic acids (rats), 417E, effect on Ca� uptake (rab-

bits), 347E,, -induced intestinal secre-

tion, alpha-2 adrenergic in-hibition of (rats), 637

E, role in bradykinin edemaformation (dogs), 293

E1 and E2, radioirnrnunoassayfor pulmonary rnetabolites of(rabbits, man, dogs), 229

F�,,, -mediated pulmonary andsystemic vasoconstriction,

antagonism by N-dimethyl-

amino analog (rats), 521synthesis by isolated giorneruli

and aortjc strips, effect ofconverting enzyme inhibitors

(rats), 23inhibition of acid secretion in

isolated parietal cells by

(dogs), 371laxative potential of (hamsters),

236Proteins

in liver, evidence for coexist-ence of monomorphic and po-lymorphic N-acetyltransfer-ase on (rabbits), 1

striatal synaptic membrane, ef-

fect of opioid drugs on phos-

phorylation of (rats), 278

synaptosomal cytosolic, from

striatum, effects of morphineon calcium-regulated phos-phorylation of (rats), 696

Purine release, KC1-induced, from

vascular adrenergic nerves,effect of theophylline (rab-

bits), 152Purmnergic activation, urinary

bladder smooth muscle, pros-taglandin link (rabbit), 347

Purkinje fiberscardiac, effects of dantrolene

sodium on electrophysiologi-cal properties of (dogs), 157

cardiac, effects of encainide andrnetabolites on (dogs), 440

2-Pyrrolidone, effect on acetyl-

choline turnover in brain(rats), 689

Quinidine, lack ofinteraction withdigoxin in heart cells (chicks),488

[3H}Quinuclidinyl benzilate, spe-cific binding to cardiac ho-rnogenates, effect of isopro-

terenol (rats), 411

QX-3i4, effect on central nervous

Index 7111982

system neurons (guinea pigs),476

Radioimmunoassayfor prostaglandin E (rabbits),

347for pulmonary metabolites of

prostaglandin E1 and E2 (rab-bits, man, dogs), 229

Raheja, K. L., Linscheer, W. G.,Cho, C. and Mahany, D.: Pro-tective effect of propylthiou-

racil independent of its hy-pothyroid effect on acetamin-ophen toxicity in the rat, 427

Rajfer, S. I., Kohl, J. D. andGoldberg, L. I.: Contractileactions of racemic and d-pro-

pranolol on isolated caninernesenteric and coronary ar-teries, 127

Ramwell, P. W., see Stinger, R.B., 521

Raphe rnagnus, nucleus, effects ofserotonin antagonists on in-hibition of spinothalamictract cells produced by stim-ulation in (monkeys), 266

Rech, R. H., see Commissaris, R.L., 536

Receptors

A, binding of adenosine ana-logs to (mice, rats), 70

acetylcholine and beta, in iso-lated atria, effects of isopro-terenol (rats), 411

acetylcholine, inhibition by d-tubocurarine (frogs), 172

adrenergic, alpha-i, alpha-2and beta, in forebrain, corn-petition by L-a-rnethyldOpametabolites for (rats), 552

dopamine, involvement in stria-tal acetylcholine transmis-sion (rats), 197

dopamine, presynaptic, effect oftetrahydropapaveroline (rab-bits), 16

histamine H2, -mediated relax-ation of trachea (rabbits), 353

opiate, influence of nitrous ox-

ide on (mice), 499

opiate, involvement in cardio-vascular function in hypovo-lemic shock (dogs), 621, 625

opioid, multiple, mediation of

$-funaltrexamine by (mice),494

Regal, J. F.: C5a-induced aorticcontraction: Effect of anantihistamine and inhibitorsof arachidonate metabolism,

102Renin-angiotensin system, role

in arninoglycoside-inducedrenal failure (rats), 433

Respiratory effects, of morphine,pentobarbital and naloxone

in brain stern (cats), 642

Reynolds, D. G., see Gurll, N. J.,621, 625

Rikans, L E. and Notley, B. A.:Age-related changes in he-

patic microsornal drug me-tabolisrn are substrate selec-tive, 574

Robertson, D., see Goldberg, M.R., 552

Rose, J. C., see Stinger, R. B., 521

Rosow, C. E., Miller, J. M., Poul-sen-Burke, J. and Cochin, J.:Opiates and thermoregula-tion in mice. II. Effects of opi-ate antagonists, 464

Rosow, C. E., Miller, J. M., Poul-sen-Burke, J. and Cochin, J.:Opiates and thermoregula-tion in mice. III. Agonist-an-tagonists, 468

Rush, G. F., see Kuo, C.-H., 547Rutledge, C. 0., see Wince, L. C.,

340

Salatar, J. J. and Jalife, J.: Effectsof dantrolene sodium on the

electrophysiological proper-

ties of canine cardiac Par-kinje fibers, 157

Salicylate, binding to plasma pro-teins, in vivo and in vitrostudies on (man), 648

Scatton, B.: Effect of dopamineagonists and neurolepticagents on striatal acetylcho-line transmission in the rat:Evidence against doparnine

receptor multiplicity, 197Scatton, B. and Bartholini, G.: y-

Aminobutyric acid (GABA)receptor stimulation. IV. Ef-fect of progabide (SL 76002)and other GABAergic agentson acetylcholine turnover inrat brain areas, 689

Scatton, B., see lloyd, K. G., 672

Scatton, B., Zivkovic, B., Dedek,J., Uoyd, K. G., Constantini-din, J., Tissot, R and Bar-tholini, G.: -y-Aminobutyric

acid (GABA) receptor stim-ulation. III. Effect of proga-bide (SL 76002) on norepi-nephrine, dopamine and 5-hydroxytryptamine turnover

in rat brain areas, 678Schild regression analysis, assess-

rnent of pre- and postsyn-aptic alpha adrenoceptorblocking affinity of amitrip-

tyline by (rats), 299Schiondorif, D., see Galler, M., 23

Schwartz, A., see Grupp, G., 145

Secretionacid, in isolated parietal cells,

inhibition by prostaglandins(dogs), 371

intestinal, bombesin-induced(rats, guinea pigs), 449

intestinal, induced by prosta-

glandin E1, vasoactive intes-tinal peptide and dibutyrylcyclic AMP, alpha-2 adre-

nergic inhibition of(rats), 637

intestinal, neurotensin- andsubstance P-induced (rats,

guinea pigs), 456

renal, of sodium, effect of die-tary potassium (rats), 178

Segawa, T., see Nornura, Y., 411Seizures, induced by valproic acid

(mice), 654Seltzrnan, T. P., see Cook, C. E.,

568Serneyn, D. R., see Commissaris,

R. L., 536Sender, M., see Gullikson, G. W.,

236Serotonin (see also 5-Hydroxy-

tryptamine)analog, inhibition of phrenic

and sympathetic vasornotorneurons by (cats), 39

antagonists, effects on brain-stern inhibition (monkeys),266

brain, turnover rate, effect of L-

5-hydroxytryptophan (rats),

579

effect of superior cervical gan-glionectorny on sensitivity ofear and cerebral arteries to(rabbits, cats), 49

in spinal cord, effects of 6-hy-droxydopamine and 5,6-di-hydroxytryptamine on deple-tion of (rats), 311

Serum, dopamine-f3-hydroxylase,effect of diabetes (rats), 108

Serum glutarnic-oxalacetic tram-arninase, role in evaluation ofacetaminophen hepatotoxic-

ity (rats), 427Serum glutamic-pyruvic tram-

aminase, role in evaluation ofacetaminophen hepatotoxic-ity (rats), 427

Shader, R. I., see Greenblatt, D.J_, 120

Shaker, N., Eldefrawi, A. T.,Aguayo, L G., Warnick, J. E.,Albuquerque, E. X. and Eld-

efrawi, M. E.: Interactions ofd-tubocurarmne with the mc-otinic acetylcholine receptor/channel molecule, 172

Sherman, S., see Berkowitz, B. A.,329

Shigenobu, K., see Ishii, K., 209

Shock, hypovolemic, effect of nal-ozone on cardiovascular

function in (dogs), 621, 625Short-circuit current, in ileurn, ef-

fect of bornbesin and relatedpeptides on (rats, guineapigs), 449

in ileurn, effect of neurotensinand substance P on (rats,guinea pigs), 456

Skoglund, M. L., Nies, A. S. and

Gerber, J. G.: Inhibition of

acid secretion in isolated ca-nine parietal cells by prosta-glandins, 371

SL 75102anticonvuLsant actions, kinetic

and metabolic properties andneuropharmacological pro-

files (mice, rats, cats), 660effect on acetylcholine turnover

in brain (rats), 689

specificity for -y-aminobutyric

acid receptor in brain (rats,rabbits, mice), 672

Slack, B. E., Downie, J. W. andElbadawi, A.: Paradoxical re-sistance to adrenolytic agents

of field-stimulated bladderbase of rabbit, 216

Slizgi, G. R. and Ludens, J. H.:Studies on the nature andmechanism ofthe diuretic ac-tivity of the opioid analgesicethylketocyclazocine, 585

Slotkin, T. A., see Lau, C., 629

Smith, H. E., see Goldberg, M. R.,552

Smith, J. H., Braselton, W. E.,Tonsager, S. H., Mayor, G. H.

and Hook, J. B.: Effects of

vanadate on organic ion ac-

cumulation in rat renal cor-tical slices, 540

Smith, P. M., see Hurwitz, L, 382

Smith, T. W., see Horowitz, J. D.,488

Smooth muscle (see Muscle,smooth)

Snow, A. E. and Horita, A.: Inter-action of apomorphine andstressors in the production ofhyperthermia in the rabbit,335

Spinal cord, effects of 6-hydroxy-dopamine and 5,6-dihydrox-ytryptamine on depletion ofnorepinephrine and sero-tonin in (rats), 311

SQ 20,881, effect on prostaglandinsynthesis (rats), 23

SRS-A, effects on isolated pul-

rnonary arteries (guineapigs), 526

Statham, C. N., see Devereux, T.R., 223

Stier, C. T., Jr., Cowden, E. A.and Allison, M. E. M.: Effects

of brornocriptine on singlenephron and whole-kidneyfunction in rats, 366

Stimulation, oflocornotor activityby morphine and nitrous ox-

ide (mice), 499

Stinger, R. B., Fitzpatrick, T. M.,Corey, E. J., Ramwell, P. W.,Rose, J. C. and Kot, P. A.:Selective antagonism of pros-taglandin F�,,-rnediated vas-cular responses by N-dimeth-ylamino substitution of pros-taglandin F�, 521

Stolk, J. M., see Hurst, J. H., 108

Stomach, inhibition by prosta-glandins of acid secretion inisolated parietal cells in(dogs), 371

Streptomycin, inhibition of renalphosphatidylinositol phos-pholipase C by (rats), 287

Streptozotocin-induced diabetes,

effect on circulating dopa-mine-fl-hydroxylase activity

(rats), 108

Striatum

brain, -y-aminobutyric acid(GABA) mediation in benzo-diazepine inhibition of Mets-enkephalin in (rats), 616

brain, effects of morphine oncalcium-regulated phospho-rylation of synaptosomal cy-tosoic proteins from (rats),

696

effects of -y-aminobutyric acidreceptor agonists on acetyl-

585

712 Index Vol. 220

choline turnover in (rats), 689

effects of ethanol on cholinergicsystem in (mice), 203

synaptic plasma membraneproteins, effect of opioiddrugs on phosphorylation of(rats), 278

tyrosine hydroxylase, effects ofmolindole on (rats), 609

Su, C., see Araki, H., 49Su, C., see Katsuragi, T., 152Substance P, effect on potential

difference and short-circuitcurrent in ileum (rats, guineapigs), 449, 456

Sulfadiazine, N-acetylation inliver (rabbits), 1

Sulfamethazine, N-acetylation inliver (hamsters), 8

Superior cervical ganglia, inhibi-tion of norepinephrine up-take by xylamine in (rats),115

Survival rate, effects of naloxone(dogs), 621, 625

Suzuki, Y., see Asano, M., 191

Svensj#{246},E., see Prasad, C. M., 293

Sympathectomy, immunologicaland chemical postjunctionalsupersensitivity in heart pro-

duced by (rats), 209Synaptosornes, comparative ac-

tions of phenytoin and otherdrugs on potassium- and ye-ratridine-stimulated calciumuptake in (rats),29

Tabachnik, N. F., Blackburn, P.,Peterson, C. M. and Cerami,A.: Protein binding of N-2-rnercaptoethyl-1,3-diarnino-propane via mixed disulfideformation after oral adminis-tration of WR 2721, 243

Tachyphylaxis, norepinephrineand serotonin (rats), 311

Takernori, A. E., see Ward, S. J.,494

Tallent, C. R, see Cook, C. E., 568Temperature, body, effects of opi-

ates on (mice), 464, 468Testis, toxic effects of 1,2-di-

bromo-3-chloropropane, roleof glutathione (rats), 399

Tetrahydropapaveroline, presyn-

aptic effects on striatal do-paminergic neurons (rabbits),16

Theophylline, role in KC1-in-duced purine release from

vascular adrenergic nerves(rabbits), 152

Thiamine-P, antinociceptive ef-fect (mice), 482

Timmerman, D., see Pastoriza-

Munoz, E., 604

Tissot, R., see Scatton, 13., 678Tobramycin, inhibition of renal

phosphatidylinositol phos-pholipase C by (rats), 287

Tolerancemethadone-induced (pigeons),

592to hypothermic effects of pen-

tobarbital (rats), 536

Tonsager, S. R., see Smith, J. H.,540

Toxicity, of acetaminophen, ef-fects of propylthiouracil-in-duced hypothyroidism andtriiodo-L-thyronine-inducedhyperthyroidisrn on (rats),427

Trachea, histamine H2-receptor-mediated relaxation of (rab-bits), 353

Transmission

acetylcholine, striatal, effect of

dopamine agonists and neu-roleptic agents on (rats), 197

cerebral cholinergic, effect of

-y-aminobutyric acid receptoragonists on (rats), 689

neuromuscular, inhibition by d-tubocurarine (frogs), 172

Transportof fluid, small intestine, effect

of nonsteroidal anti-inflarn-

matory drugs (hamsters), 236

of ileal epithelial electrolyte,

neurohumoral control of(rats, guinea pigs), 449,456

of purine in kidney, effects ofprobenecid and 4-acetamido-4’-isothiocyano-stilbene-2, 2’-disulfonic acid (chickens), 86

renal, inhibition by vanadate(rats), 540

Triiodo-L-thyronine-induced hy-

perthyroidism, effect on ac-etaminophen toxicity (rats),427

Tryptophan, effect on norepi-nephrine and doparnine con-centrations in brain (rats),579

d-Tubocurarmne, interactions withacetylcholine receptor and

channel (frogs), 172

Tung, C.-S., see Goldberg, M. R.,552

Tyrosine hydroxylase, striatal, ef-fects of molindone on (rats),

609

Uric acid, accumulation by renalcortex slices, comparison

with hypoxanthine (chick-

ens),86

Urine volume, effect of ethylke-tocyclazocine on (rats, toads),

Valproic acidbiliary excretion and choleretic

action, effect of inducers andinhibitors of glucuronidationon (rats), 305

brain, anticonvulsant effects(mice), 654

Vanadate, effects on organic ion

accumulation in renal corti-cal slices (rats), 540

Vas deferens, presynaptic alphaadrenoceptor blocking affin-ity of amitriptyline in (rats),299

Vargish, T., see Gurll, N. J., 621,625

Vasoconstriction, pulmonary and

systemic, mediated by pros-taglandin F�,, (rats), 521

Vasodilation, by ibuprofen inheart (rabbits), 167

Vasopressin

analgesia, characterization of(mice, rats), 329

inhibition of edema by (dogs),

293Vasotocin, comparison with va-

sopressin (mice, rats), 329

Ventricular fibers, cardiac, effectsof encainide and metabolites(dogs), 440

Verapamil

effect on propranolol-inducedcontractions in mesenteric

and coronary arteries (dogs),127

myocardial disposition and car-

diac pharmacodynamics(dogs), 91

Verburg, M., see Bothwell, W.,229

y-Vinyl y-aminobutyric acid, an-

tinociceptive effect (mice),482

Vogel, W. M., see Apstein, C. S.,167

Wang, M.-Y., see Feldman, S., 514Ward, S. J., Portoghese, P. S. and

Takernori, A. E.: Pharmaco-logical characterization invivo of the novel opiate, $-funaltrexamine, 494

Warnick, J. E., see Shaker, N., 172

Watkins, J. B. and Klaassen, C.D.: Effect of inducers and in-hibitors of glucuronidation

on the biiary excretion andcholeretic action of valproicacid in the rat, 305

Weber, W. W., see Hein, D. W., 1,

8

Weinberger, M. H., see Luft, F.C., 433

Wilcox, T. K., see Yezierski, R P.,266

Will, J. A., see Hand, J. M., 526Williams, N. and Clouet, D. H.:

The effect of acute opioid ad-ministration on the phospho-rylation of rat striatal synap-

tic membrane proteins, 278Willis, W. D., see Yezierski, R. P.,

266

Wince, L. C. and Rutledge, C. 0.:

Developmental changes in

the accumulation of norepi-nephrine and the chrono-tropic effects of catechol-

amines in isolated rat atria asinfluenced by dietary lipid,340

influenced by dietary lipid,

Woolverton, W. L., see Brady, K.T., 56

Wooten, J. D. III, see Cook, C. E.,568

Worms, P., Depoortere, H., Dur-and, A, Morseffi, P. L, Uoyd,K. G. and Bartholini, G.: -y-

Aminobutyric acid (GABA)receptor stimulation. I.Neuropharmacological pro-files of progabide (SL 76002)and SL 75102, with emphasison their anticonvuisant spec-tra, 660

Worth, T., see Dunwiddie, T. V.,

70WR 2721, rnucolytic drug, conver-

sion to N-2-mercaptoethyl-

1,3-diarninopropne afteroral administration (rabbits,man), 243

WR 171,669, imrnunoassay of(rabbits), 568

Wynalda, M., see Bothwell, W.,

229

Xylamine, inhibition of norepi-

nephrine uptake in superiorcervical ganglia by (rats), 115

Yaksh, T. L., see Howe, J. R., 311Yamamoto, S., see Nakaki, T., 637Yang, H.-Y. T., see Harsing, L. G.,

Jr., 616

Yezierski, R. P., Wilcox, T. K. andWillis, W. D.: The effects ofserotonin antagonists on theinhibition of primate spino-thalamic tract cells produced

by stimulation in nucleusraphe rnagnus or periaque-

ductal gray, 266

Yu-Drent, P., see Erickson, R. R.,

35

Zipes, D. P., see Elharrar, V., 440

Zitaglio, T., see Christ, D., 97

Zivkovic, B., see Scatton, B., 678