The editor of The Journal of Pharmacology and Experimental Therapeutics wishes to express appreciation to the following

colleagues who acted as Guest Editors for Specific Fields in 1981:

Additionally sincere thanks are due to 585 of our colleagues not on the Editorial Advisory Board who reviewed articles for the

Journal in 1981.

828

Edson X. Albuquerque

Edmund G. Anderson

Lewis Aronow

W. S. Aronow

Donald R. Bell

Eliezer Benjamini

John A. Bevan

Rubin Bressler

Theodore J. Cicero

Howard D. Colby

Allan H. Conney

Alan Cowan

Brian M. Cox

William C. de Groat

George I. Drummond

Donald W. DuCharme

James A. Ferrendelli

Dora B. Goldstein

Garrett J. Gross

Perry V. Halushka

Harold F. Hardman

Jordan L. Holtzman

Lindsay B. Hough

Donald J. Jenden

Robert M. Joy

Alain F. Junod

Philip J. Kadowitz

Irwin J. Kopin

Harvey J. Kupferberg

Robert J. Letkowitz

Louis Levy

Peter Lomax

Kafait U. Malik

Steven E. Mayer

John C. McGiff

W. H. Morse

Alberto Nasjletti

James Nathanson

John A. Pickrell

Arthur Raines

Eugene Renkin

G. Alan Robison

Betty Sasyniuk

Lewis S. Seiden

Eric J. Simon

Roger P. Smith

R. D. Spealman

Frank G. Standaert

Larry G. Stark

A. E. Takemori

M. Villareal

Frank F. Vincenzi

Theodore C. West

David P. Westfall

Thomas Westfall

Martin M. Winbury

Dixon M. Woodbury

Arthur Yuwiler

Ben G. Zimmerman

829

INDEX

Volume 221 , April-June, 1982

Aarons, R. D. and Molinoff, P. B.:Changes in the density ofbeta adrenergic receptors in

rat lymphocytes, heart and

lung after chronic treatmentwith propranolol, 439

Aaronson, L M., Hinman, D. J.and Okamoto, M.: Effects ofdiazepam on ethanol with-drawal, 319

Acetaminophen

metabolism by kidney (rats), 76pharmacokinetics, effect of

renal failure on (rats), 80sulfate conjugation, kinetics of

(man), 43test drug to study effects of ab-

sorbents and cathartics onabsorption of drugs given by

mouth (dogs, mice), 656

Aceto, M.D., see Tripathi, H. L.,91

Acetylcholine

inhibition of quinuclidinyl ben-zilate binding to pial bloodvessel membrane by (cows),85

interaction with phenoxylben-zyamine at nicotinic receptor

(cats), 117

release, norepinephrine-in-duced, effect of amphetamineon (rats), 14

[‘H]Acetylcholinesynthesis and release in colonic

mucosa (rats), 664

Ackerman, N., Martinez, S.,Thieme, T. and Mirkovich,A.: Relationship between ad-herence, chemotaxis and theaccumulation of rat polymor-phonuclear leukocytes at aninflammatory site, 701

Action potential, duration in pap-illary muscle, effects of iso-

proterenol (guinea pigs), 806

Ca� �-Adenosine triphosphatase,smooth muscle, inhibition by

nanadate (rats), 197

Na,K-Adenosine triphosphatase,smooth muscle, inhibition byouabain (rats), 197

Adrenergic receptor, alpha.2,blockade by prazocin in sinusnode (dogs), 801

Adrenoceptor, beta, blockade,coronary blood flow redistri-bution induced by (dogs), 740

Adrenoceptors (see also Adrener-gic receptors)

alpha-i, blockade of amphet-amine enhancement of mus-cle twitch and acetyicholinerelease by (rats), 14

alpha-2 and beta, extrasynaptic

location in vascular system(rats), 762

beta, cardiac, desensitization bycathecholamines (rats), 784

Adsorbents, effects on absorptionof drugs given by mouth

(dogs, mice), 656

Afterpotentials, oscillatory, in-duced by digitalis in ventnc-

ular tissues, effects of amri-

none (dogs), 188

Age, effects on haloperidol phar-macokinetics (rats), 434

Aging, functional deficits of dia-phragm during (rats), 629

Agonists, phenoxybenzamine andnicotinic, metaphiic effect

(cats), 117

Alderdice, M. T. and McMillan, J.

E : Comparison of the effects

of trimethadione and its pri-mary metabolite dimetha-

dione on neuromuscular

function and the effects of al-

tered pH on the actions of

dimathadone, 547

Aldrich, T. K., see Forman, H. J.,428

Ali, F. M., see Faraj, B. A., 558Alkadhi, K. A., see Voile, R. L.,

570

Alien, R. C., see Knodeil, R. G., 1

Almeida, A. P., see Lo, T. N., 261

Altenbern, D., see Roden, D. M.

552

Alveolar macrophages, paraquatuptake and redox kinetics of

(rats), 428y-Aminobutyric acid, receptor

binding, effect of naloxone

(rats), 444Aminohippurate, relationship to

riboflavin transport in renalslices (rabbits), 394

Aminopeptidase, role in degrada-tion of enkephalin in ileum(guinea pigs), 104

Aminopyrine, induction of he-

patic y-glutamyl transpepti-

dase by (rats), 795

Amphetamineconformations and central

nervous system activity(rats), 58

-induced behavioral function,

role of striatal dopaminergic

receptors (rats), 650

d-Amphetamine

effect on schedule-controlled

responding (man), 373

effects on classical conditioningof nictitating membrane re-sponse (rabbits), 289

(+)-Amphetamine, enhancementof neuromuscular transmis-

sion (rats), 14

Amrinone

inotropic and electrophysio-logic effects in untreated anddigitalized ventricular tissues

(dogs), 188

positive inotropic effect in re-

lation to cyclic nucleotide

metabolism in ventricular

muscle (dogs), 775

Analgesia, morphine-induced, ef-fects of naloxone (rats), 444

Analogs, of pyridoxai, evaluation

of iron-chelating drugs de-rived from (rats), 399

Anderson, Gordon F. and Marks,B. H.: Spare cholinergic re-ceptors in the urinary blad-

der, 598

Angiotensin converting enzyme,

role in dehydration of ence-phalin in ileum (guinea pigs),

104

Antagonists

beta adrenergic, effects on

drinking and pressor re-

sponses after renal artery

constriction (rats), 4535-hydroxytryptamine, interac-

tions with lysergic acid dieth-

ylamide (rats), 206

Antiarrhythmic activity of 0-di-

methyl encainide (rats), 552

Anticonvulsant effects of pheny-

tom and phenobarbital

(frogs, mice), 132

Antigen-induced contractions,

release of slow reacting sub-

stance of anaphylaxis from

lung during (guinea pigs), 146

Antihypertensive action of L-

tryptophan, studies on (rats),

329

Antinociception

nicotine-induced, correlation

with nicotine brain levels

(rats, mice), 91

of morphine (mice), 362

Antonaccio, M. J., see Saini, R.K., 29

Antzelevitch, C., see Lamanna, V.,353

Aortaeffects of clonidine and yuhim-

bine on alpha adrenergic re-ceptors in (rats, guinea pigs,

rabbits, hamsters, dogs, cats),

309

smooth muscle, vascular toler-

ance to nitroglycerin and

cyclic GMP generation in(rats), 525

Aortic contraction, norepineph-

rine-induced, role of intracel-

lular calcium (rats), 7

Apomorphine, inhibition of nor-

epinephrine release in central

nervous system by (rabbits),4’l

Appel, J. B., see White, F. J., 421

Arachidonic acid-induced vaso-

constriction in kidney, possi-

ble involvement of throm-

boxane A� (rats), 614

Arene oxide, role as teratogen forhydantoins (mice), 228

Arrhythmias

cardiac, reflection, reentry ef-

fects of lidocaine on (dogs),

353ventricular, associated with cor-

onary artery reperfusion, ef-

fects of tiapamil on (dogs), 29

Artery

basilar, mechanisms of 15-hy-

droperoxyarachidonic acid-

induced contraction of

(dogs), 481

coronary stenosis, effects of tia-

pamil (dogs), 29

renal, interaction betweenrenin-angiotensin and beta

adrenergic systems after con-

striction of (rats), 453

Aspirin, effects on bradykinin-me-

diated prostaglandin E� and

cyclic GMP syntheses in

renal inner medulla slices

(rabbits), 532Atkinson, J., L#{252}thi, P., P#{233}ra-

Bally, H. and Peters-Haefeli,

L.: Interaction between therenin-angiotensin and beta

adrenergic nervous systems

in drinking and pressor re-

sponses after renal artery

constriction, 453

Atkinson, N., see Petersen, D. H.,275

Atria, inotropic and chronotropic

effects of vasodilators (guineapigs), 609

Atropine, inhibition of quinucli-

dinyl benzilate binding to pial

blood vessel membranes by

(cows), 85

Bacopoulos, N. G., Bustos, G.,Redmond, D. E., Jr. andRoth, H. H.: Chronic treat-

ment with haloperidol or flu-

phenazine decanoate: Re-

gional effects on dopamine

and serotinin metabolism inprimate brain, 22

Barbella, Y. R., see Israel, A. S.,

577

Barchas, J. I)., see Roth, K. A.,

416

Barker, L. A. and Ebersole, B. J.:

830 Index Vol. 221

Histamine H2-receptors onguinea-pig ileum myentericplexus neurons mediate therelease of contractile agents,69

Barnes, G., see Slotkin, T. A., 686Beaven, M. A., see Lo, T. N., 261

Beck, T. R., Hassid, A. and Dunn,M. J.: Desamino-d-argininevasopressin induces fatty

acid cyclooxygenase activity

in the renal medulla of dia-

betes insipidus rats, 269

Behavior

anticonvulsant effects of

phenytoin and phenobarbital

(frogs, mice), 132discriminative stimulus effects

of lisuride (rats), 421

discriminative stimulus proper-

ties of fentanyl and ethylde-

tocyclazocine (rats), 735

drug discrimination analysis of

lysergic acid diethylamine

(rats), 206effects of d-amphetamine and

diazepam on schedule-con-

trolled responding (man), 373effects of cocaine on pentobar-

bit.al on fixed-interval and

second-order schedules of de-livery (monkey), 384

facilitation by amphetamine,role of striatal dopaminergic

receptors (rats), 650

interaction between renin-an-

giotensin and beta adrenergicnervous systems in drinkingand pressor responses after

renal artery constriction(rats), 453

intravenous self-administration

of phencyclidine and relatedcompounds (dogs), 637

multiple drug discrimination

training (rats), 166

naloxone sensitization blockedby food deprivation (rats),

444state development in newborn,

effects of theophylline (rab-bits), 604

Benowitz, N. L., Jacob, P. III,Jones, R. T. and Rosenberg,J.: Interindividual variabilityin the metabolism and car-

diovascular effects of nicotine

in man, 368

Benzodiazepines, effect on

ethanol withdrawal (cats),

319Berdeaux, A., Duhaze, P. and Giu-

dicelli, J.-F.: Pharmacological

analysis of beta adrenoceptorblockage-induced coronaryblood flow redistribution indogs using T-penbutolol, 740

Bhargava, H. N., see Gray, N. M.,58

Biassoni, F., see Brambillar, G.,222

Bileeffects of dihydroxydibutyl

ether (rats), 769production, in liver, comparison

of vanadate and ouabain ef-

fects on (rats), 197

Binding, irreversible, of 2-meth-ylnaphthalene (mice), 517

Blackshear, M. A. and Sanders-Bush, E.: Serotonin receptorsensitivity after acute and

chronic treatment with mian-serin, 303

Bleomycin A2interaction with lung micro-

somes, characterization of

factors which influence bleo-

mycin-mediated DNA chain

breakage (rats), 152interaction with lung micro-

somes, involvement of iron

and oxygen in bleomycin-me-diated DNA chain breakage(rats), 159

Block, E. R. and Schoen, F. J.:Depression of serotonin up-take by rat lungs exposed to

paraquat, 254

Blood flow, myocardial, redistri-bution induced by beta adre-

noceptor blockade (dogs), 740

Blood pressureeffect of guanabenz on (dogs),

347

effect of nicotine on (man), 368

effect of L-tryptophan on (rats),

329

effects of propranolol and par-alasin (rats), 453

Blood vessels, pial, muscariniccholinergic receptor sites in

(cows), 85

Bloom, A. S.: Effect of i�9-tetra-hydrocannabinol on the syn-

thesis of dopamine and nor-

epinephrine in mouse brainsynaptosomes, 97

Bond, J. H., see Knodell, R. G., 52

Borda, L., see Perez, J. E., 609Bostick, S. P., see Weichman, B.

M., 295

Bourdeau, J. E., Buss, S. L., andVurek, G. G.: Inhibition ofcalcium absorption in the

cortical thick ascending limb

of Henle’s loop by furose-

mide, 815

Bradykinin-mediated prostagian-

din E2 and cyclic GMP syn-thetases in renal inner me-dulls slices (rabbits), 532

Braincatecholamine, effect of nico-

tine on concentration and

turnover (rats), 416cerebral cortex, norepinephine

enhancement of inhibitingsynaptic mechanisms in(rats), 495

development in newborn, ef-fects of dexamethasone(rats), 686

dopamine and serotonin metab-olism, effects of haloperidoland fluphenazine (monkeys),22

nicotine levels, correlation with

nicotine-induced antinoci-

ception (rats, mice), 91

serotonin, effects of stereoiso-

mers of aminobenzonorbor-nenes on (rats), 58

synaptosomes, effect of i�-te-trahydrocannabinol on syn-thesis of dopamine and nor-epinephrine in (mice), 97

Brambilla, G., Cavanna, M.,Maura, A., Pino, A., Robbi-ano, L., Carlo, P., Biassoni, F.and Ricci, R.: Absence ofDNA damage in liver of ratsgiven high doses of cimeti-dine and sodium nitrite, 222

Branch, R. A., see K#{252}pfer,A., 590

Branch, R. A., see Jackson, E. K.,183

Branisteanu, D. D., see Voile, R.L., 570

Braselton, W. E., Jr., see Newton,J. F., 76

Breath analysis, accelerated 7-

[methoxy- ‘4C]coumarin-de-rived dioxide exhalation in-

duced by cobalt pretreatment(mice), 790

Breger, R. K., see Griffin, K. A.,517

d-2-Bromolysergic acid diethyl-amide, effects on classical

conditioning of nictitating

membrane response (rab-bits), 289

Bronchoconstnction, induced byprostaglandin F2,, and hista-

mine, effects of nifedipine(dogs), 410

a-Bungarotoxin, binding to elec-

tric organ microsacs and my-otubes, effects of ketamine

and ditran (ray, chick), 570

Bupropion disposition, relation-ship to dopamine uptake in-hibition (rats, mice), 676

Burke, J. A., Levi, R., Guo, Z.-G.and Corey, E. J.: Leuko-trienes C.,, D4 and E4: Effectson human and guinea-pigcardiac preparations in vitro,

235

Burkman, A. M., see Keith, R. A.,525

Buss, S. L., see Bourdeau, J. B.,815

Bustos, G., see Bacopoulos, N. G.,22

Butaclamol, selective blockade ofperipheral dopamine recep-tors (dogs), 753

Butler, V. P., Jr., Tse-Eng, D.,Lindenbaum, J., Kalman, S.M., Preibisz, J. J., Rund, D.G. and Wissel, P. 5.: The de-velopment and application ofa radioimmunoassay for di-hydrodigoxin, a digoxin me-tabolite, 123

Butylated hydroxanisole, effecton glutathione transferase(mice, rats), 242

Butz, R. F., Welch, R M. andFindlay, J. W. A.: Relation-ship between bupropion dis-position and dopamine up-take inhibition in rats and

mice, 676

Bylund, D., see Snell, D., 444

Cacini, W., Keller, M. B. and

Grund, V. R.: Accumulationof cimetidine by kidney cor-

tex slices, 342

Calciumabsorption in cortical thick as-

cending limb of Henle’s loop,inhibition by furosemide

(rabbits), 815effect of reserpine pretreatment

on inotropic responsivenessof heart to (guinea pig), 721

effects on bradykinin-mediatedprostaglandin E2 and cyclicGMP synthesis in renal innermedulla slices (rabbits), 532

intracellular, role in contractile

effects of norepinephrine in

aorta (rats), 7

role in effects of isoproterenolon action potential durationin papillary muscle (guineapigs), 806

Calcium channel blocker, effect

on pharmacological-induced

bronchoconstriction (dogs),

410Ca-mediated responses in parotid

gland, effect of ionomycin

(rats), 247

Captopril, role in degradation of

enkephalin in ileum (guinea

pigs), 104

Carbachol, inhibition of quinucli-dinyl benzilate binding to pialblood vessel membranes by(cows), 85

Carbon dioxide, 7-[methoxy. ‘4C]coumarin-derived, acceler-

ated exhalation induced bycobalt pretreatment (mice),

790

Cardiac effects of vasodilators(guinea pigs), 609

Cardiovascular effects of nicotine

(mice), 368

Carlo, P., see Brambilla, G., 222Carrageenan-induced inflamma-

tory responses, effect of in-

domethacin (rats), 261Catecholamine (see also specific

name)release, from adrenal gland, ef-

fect of nicotine, acetylcholine

and nerve stimulation (cats),117

synthesis in pheochromocy-toma cells, inhibition by mo-nesin, 536

Catecholaminesbrain, effect of nicotine on con-

centration and turnover(rats), 416

brain, effect of reserpine on dif-

ferences in sensitivity of(mice), 404

desensitization of cardiac beSa

adrenoceptors by (rats), 784plasma, effects of stress (guinea

pigs), 577

Cathartics, effects on absorptionof drugs given by mouth

Index 8311982

(dogs, mice), 656

Cavanna, M., see Brambillar, G.,222

Cerebellumbinding of triazolopyridazine to

benzodiazepine receptor in(rats), 670

norepinephrine enhancement

of inhibitory synaptic mech-anisms in (rats), 495

Cerebrospinal fluid, transport ofendorphins to lower sectionsof spinal cord via (mice), 362

Chang, H. Y., Klein, R. M. andKunos, G.: Selective desensi-tization of cardiac beta adre-noceptors by prolonged in

vivo infusion of catechol-amines in rats, 784

Charocopos, F., Hatzinikolaou, P.and Dipetti, D.: Different he-modynamic response afteracute diuresis in the normo-

tensive and hypertensive

state, 315

Choleresis, induced by dihydrox-ydibutyl ether (rats), 769

Cholestasis, by harmol glucuro-

nide (rats), 731Choline acetyltransferase, cere-

brovascular activity (cows),

85

Chromaffin granules, effect of mo-nesin on catecholamine

release from, 536Cigarettes, metabolism and car-

diovascular effects of nicotine

from (man), 368

Ciguatoxin-induced supersensi-

tivity in vas deferens (guineapig), 748

Cimetidine

accumulation by renal cortexslices (dogs), 342

effect on DNA damage in liver

(rats), 222Chine, W. H., Jr., see Kawasaki,

H., 112

[‘4C]Clofilium, disposition, corre-lation to cardiac electrophys-iological effects (rats, dogs),

584Clonidine

effect on alpha adrenergic re-ceptors in aorta (rats, guinea

pigs, rabbits, hamsters, dogs,

cats), 309inhibition of serotonin synthe-

sis and metabolism (rats), 541

Cobalt pretreatment, accelerationof 7-[methoxy- ‘4C]coumarin-derived carbon dioxide exhal-ation by (mice), 790

Cocaine, behavior maintained Un-der fixed-interval and sec-ond-order schedules of deliv-ely by (monkeys), 384

Cohen, J. and Neff, N. H.: Acti-vation of retinal tyrosine hy-

droxylase: Tolerance inducedby chronic treatment withhaloperidol does not modify

response to light, 326Cohen, M., L., see Geary, L. E.,

104

Colon, mucosa, cholinergic nerveendings in (rats), 664

Colpaert, F. C., Niemegeers, C. J.

E. and Janssen, P. A. J.: Adrug discrimination analysis

of lysergic acid diethylamide

(LSD): In vivo agonist andantagonist effects of pur-ported 5-hydroxytryptamine

antagonists and of pirenpe-rone, a LSD-antagonist, 206

Compound 48/80-induced inflam-matory responses, effect of

indomethacin (rats), 261

Contractile force of myocar-dium, effects of leukotrienesC4, D4 and B4 (man, guineapigs), 235

Contractions

antigen- or ionophore-induced,release of slow reacting sub-stance of anaphylaxis from

lung during (guinea pigs), 146

of basilar artery, induced by 15-hydroperoxyarachidonic acid

(dogs), 481

Conway, P. G. and Uretsky, N. J.:Role of striatal dopaminergicreceptors in amphetamine-induced behavioral faciita-tion, 650

Cool, V. A., see Harvey, J. A., 289

Corbic, M., Dumont, M., De-Couet, G. and Erlinger, S.:

Choleretic and diuretic prop-erties of dihydroxydibutylether in the rat, 769

Corey, E. J., see Burke, J. A., 2357-[Methoxy- ‘4C]Coumarin-de-

rived carbon dioxide exhala-tion, increased by cobalt pre-

treatment (mice), 790

Creatine kinase, release from skel-etal muscles induced by imi-

pramine (frogs), 489Cubeddu, L. X., see Israel, A. S.,

577Cyanide detoxification, role of

erytb.rocytes in (man), 37Cyclic AMP

central nervous system levels,

effect of phenytoin (frogs,

mice), 139

prostaglandin E1-mediated, ef-

fect ofethanol on (clone), 334

Cyclic GMPcentral nervous system levels,

effect of phenytoin (frogs,

mice), 139

generation in aortic smoothmuscle relationships to vas-cular tolerance to nitroglyc-erin (rats), 525

synthesis in renal inner medullaslices, mediated by bradyki-

nm (rabbits), 532Cyclic nucleotide metabolism, in

ventricular muscle, positiveinotropic effect of amrinonerelated to (dogs), 775

Cyclooxygenase activity in renalmedulla, effect of desamino-D-argmine vasopressin (rats),269

Cytochrome P-450

molecular activity, decreaseafter cobalt pretreatment(mice), 790

reduced, induced by oleando-mycin (rats), 215

Davis, B. B., see Zenser, T. V., 532Dayton, H., see Van DeGraaff, W.

B., 656

DeCouet, G., see Corbic, M., 769Delorme, A. M., see Shiverick, K.

T., 564

O-Demethyl encainide, antiar-rhythmic activity (rats), 552

Denenberg, V. H., Zeidner, L. P.,Thoman, B. B., Kramer, P.,Rowe, J. C., Phiipps, A. F.and Raye, J. R.: Effects oftheophylline on behavioral

state development in thenewborn rabbit, 604

1 -Desamino-8-D-arginine vaso-

pressin effect on medullary

cyclooxygenase activity in

kidney (rats), 269

Descatoire, V., see Pessayre, D.,215

Desmond, P. V., see K#{252}pfer,A.,590

Detoxification of cyanide, role of

erythrocytes in (man), 37

Dexamethasone

effects of adherence, chemo-

taxis and accumulation ofpolymorphonuclear leuko-cytes (rats), 701

effects on development of brainand heart in newborn (rats),686

Dewey, W. L., see Ohl&son, A. E.,362

Dextran-induced inflammatoryresponses, effect of indo-

methacin (rats), 261Diabetes insipidus, renal medulla,

desamino-D-arginine vase-

pressin induces cyclooxygen-ase activity in (rats), 269

Diaphragm, functional deficits

during aging (rats), 629

Diazepam

effect on schedule-controlledresponding (man), 373

effects on ethanol withdrawal(cats), 319

Diethylstilbestrol, transplacental

pharmacokinetics, compari-

son with 17$-estradiol (mon-keys), 173

Digitalis-induced oscillatory af-

terpotentials and aftercon-tractions in ventricular tis-sues (dogs), 188

Digoxin, conversion to dihydrodi-goxin (rabbits, man), 123

Dihydrodigoxin, developmentand application of a radioim-munoassay for (rabbits,

man), 123Dihydroxydibutyl ether, choler-

etic and diuretic properties

(rats), 769Dimaprit, actions on histamine H2

receptors on ileum (guinea

pigs), 69

Dimercaptosuccinic acid, mobii-zation and removal of meth-ylmercury during extracor-pores! complexing hemodi-alysis with (dogs), 63

Dimethadione, effects on neuro-muscular functions, compari-son with trimethadione

(frogs), 547

dl-2,5-Dimethoxy-4-methylam-

phetamine, effects on classi-

cal conditioning of nictit.ating

membrane response (rab-bits), 289

Dipetti, D., see Charocopos, F.,315

Disposition

bupropion, relationship to do-pamine uptake inhibition

(rats, mice), 676

drug, effect of estrogen (rats), I

of [#{176}C]clofilium, correlation tocardiac electrophysiological

effects (rats, dogs), 584

of mephenytoin enantiomers

(man), 590

of morphine and pentobarbital,

effects of liver congestion

(rats),.52

Ditran, effects on acetylcholine

receptors and ion channels inelectric organ microsacs andmyotubes (ray, chick), 570

Diuresisdifferent hemodynamic re-

sponses in normotensive andhypertensive state after

(rats) 315

induced by dihydroxydibutyl

ether (rats), 769

. Dixon, J. F., see Marshall, P. J.,645

Dixon, W. R., see Gaddis, R. R.,

282

DNA damagebleomycin-mediated, charac-

terization of factors (rats),152

bleomycin-mediated, involve-

ment of iron and oxygen

(rats), 159

in liver, absence after high

doses of cimetidine and so-

dium nitrite (rats), 222Dopamine

role in discriminative stimulus,effects of lisuride (rats), 421

sulfate conjugation, kinetics of

(man), 43

synthesis in brain synapto-

somes, effect of �‘-tetrahy-

drocan-nabinol on (mice), 97uptake inhibition, relationship

to bupropion disposition

(rats, mice), 676

Dopamine-$-hydroxylase

effects of morphine and methi-onine on nerve stimulation-

mediated release of (cats),

282

plasma, effects of stress (guineapigs), 577

Drug metabolism, effects of liver

congestion on (rats), 52

Drugs

832 Index

antipsychotic, effects on tyro-

sine hydroxylase and dopa-

mine and serotonin metabo-

lism in brain (monkeys), 22

neuroleptic, tolerance of theretinal system to (rats), 326

Dubocovich, M. L., see Galzin, A.M., 461

Duff, H. J., see Roden, D. M., 552

Dumont, M., see Corbic, M., 769

Dunham, E. W., see Sakr, H. M.,

614

Dunn, M. J., see Beck, T. R., 269Duval, N., see Shepperson, N. B.,

753

Eastwood, A. B., see Suarez-

Kurtz, G., 489

Ebersole, B. J., see Barker, L. A.,69

Effeney, D. J. see Lo, M-W., 512

Effeney, D. J., Pond, S. M., Lo,

M.-W., Silber, B. M. and Rie-gelman, S.: A technique tostudy hepatic and intestinal

drug metabolism separately

in the dog, 507

Eldefrawi, A. T., see El-Faka-

hany, B. F., 694

Eldefrawi, M. B., see El-Faka-hany, 694

Electrophysiological effects of[‘4Clclofiuium, correlation to

disposition (rats, dogs), 584

El-Fakahany, E. F., Eldefrawi, A.T. and Eldefrawi, M. E.: Nic-otinic acetylcholine receptor

desensitization studied by

[Hiperhydrohistrionicotoxin

binding, 694Elimination of methylmercury,

effect of cysteine (dogs), 63

Encainide, antiarrhythmic activ-

ity (rats), 552Endoh, M., Yamashita, S. and

Taira, N.: Positive inotropiceffect of amrinone in relation

to cyclicnucleotide metabo-lism in the canine ventricular

muscle, 775$-Endorphin, effect on distnbu-

tion of radioactivity in spinal

cord (mice), 362

Enkephalin, degradation in ileum,

importance of aminopepti-

dase, enkephalinase and an-

giotensin converting enzyme

activity (guinea pigs), 104

Enkephalinase, role in degrada-

tion of enkephalin in ileum(guinea pigs), 104

Enzyme, retinal, activation bylight or neuroleptic drugs

(rats), 326

Enzymes, drug-metabolizing, in

liver, effects of oleandomycin

(rats), 215

Epinephrine

activation of adrenoceptors

(rats), 762hypothalamic, evidence for

cholinergic nicotinic and

muscarinic interactions with

(rats), 416

Epstein, P. M., see Voile, R. L.,570

Ergots, discriminative stimulus

effects (rats), 421Erlinger, S., see Corbic, M., 769

Erythrocytes, role in cyanide de-

toxification (man), 37Estador, C. and Krause, D. N.:

Muscarinic cholinergic recep-tor sites in cerebral blood yes-

sels, 85

Estradiol, effects on hepatic mi-

crosomal metabolism of es-

trogen (rats), 564

17fl-Estradiol, transplacental

pharmacokinetics, compan-

son with diethylstilbestrol(monkeys), 173

Estrogen

hepatic microsomal metabo-

lism, effects of thyroxine and

estradiol (rats), 564

metabolism (monkeys), 173

Ethanol

differenes in response of long

and short sleep times to(mice), 404

effect on prostaglandin E-me-

diated cyclic AMP formation

(clone), 334

increase in hepatic microsomal

ethanol oxidation by a single

dose of (mice), 275

withdrawal, effects of diazepam

on (cats), 319Ethinyl estradiol, effects on phar-

macokinetics of meperidine

and pentobarbital (rats), 1

Ethylketocyclazocine, discrimi-

native stimulus properties

(rats), 735

N-Ethylmaleimide, effects on

l9Orenal function (dogs), 623

Excretionbiliary, of sulfobromophthalein,

role of ligandin in (mice,rats), 242

of iron, effect of pyridoxal(rats), 399

urinary, ofdihydrodigoxin (rab-bits, man), 123

False tendons, effects of lidocaine

on conduction through

(dogs), 353

Faraj, A. A., Au, F. M., Fulen-

wider, J. T., Malveaus, J. andStacciarini, W. M.: Hepato-renal failure induced by tet-racycline in dogs with porta-

caval shunt, 558

Farleigh, R. M., see Knodell, R.G., 52

Feller, D., see Snell, D., 444

Fentanyl, discriminative stimulus

properties (rats), 735

Fernstrom, J. D., see Sved. A. F.,

329Ferrier, G. R., see Rosenthal, J.

E., 188

Fertel, R. H., see Keith, R. A., 525

Findlay, J. W. A., see Butz, R. F.,676

Fischman, M. W., see Tewes, P.A., 373

Fisher, A. B., see Forman, N. J.,

428

Fitzgerald, G. A., see Jackson, E.

K., 183

Fleisch, J. H., Haisch, K. D. andSpaethe, S. M.: Slow reacting

substance of anaphylaxis(SRS-A) release from guinea-

pig lung parenchyma during

antigen- or ionophone-in-duced contraction, 146

Fluphenazine, effects on dopa-

mine and serotonin metabo-

lism in brain (monkeys), 22

Food deprivation, drug effects

(rats), 444Food intake, effects of stereoiso-

mers of aminobenzonorbor-nenes on (rats), 58

Forman, H. J., Aldrich, T. K., Pos-

ner, M. A. and Fisher, A. B.:Differential paraquat uptake

and redox kinetics of ratgranular pneumocytes andalveolar macrophages, 428

Frahseck, J., see Legrum, W., 790

Franklin, R. B., see Griffin, K. A.,

517

Fredrich, L., see Van DeGraaff,

W. B., 656

Fregly, M. J., see Shiverick, K. T.,564

Fretthold, D., see Van DeGraaff,

W. B., 656Fulenwider, J. T., see Faraj, B. A.,

558

Furchgott, R. F., see Khan, M. T.,117

Furosemide

effects on meduilary thick as-cending limbs of Henle (rats),

715effect on normotension and hy-

pertension (rats), 315

inhibition ofcalcium absorption

in cortical thick ascendinglimb of Henle’s loop by (rab-bits), 815

Fu, T.-C., see Ohisson, A. E., 362

Gaddis, R. R. and Dixon, W. R.:Modulation of peripheral ad-

renergic neurotransmission

by methionine-enkephalin,

282

Gaginella, T. S., see Wu, Z.-A. C.,664

Galzin, A. M., Dubocovich, M. L.

and Longer, S. Z.: Presynap-tic inhibition by dopamine re-

ceptor agonists of noradre-

nergic neurotransmission inthe rabbit hypothalamus, 461

Gas chromatography-mass spec-

trometry, role in assessmentof conversion of prostaglan-

din 12 to 6-keto-prostaglandinB (man), 183

Gastrointestinal wall, absorptionbut no metabolism of propan-

olol by (dogs), 512

Geary, L. E., Wiley, K. S., Scott,

W. L. and Cohen, M. L.: Deg-radation of exogenous en-

kephalin in the guinea-pig

ileum: Relative importance of

aminopeptidase, enkephali-nase and angiotensin con-verting enzyme activity, 104

Vol. 221

Gemborys, M. W., see Newton, J.

F., 7

Gerald, M. C., see Snider, R. M.,

14Ginsburg, E., see Trush, M. A.,

152, 159

Giudiceili, J.-F., see Berdeaux, A.,740

Gland

parotid, actions of ionomycin in

(rats), 247perfused adrenal, interactions,

of phenoxybenzamine and

nicotinic agonists at the nic-

otinic receptor in (cats), 117

Gleason, J. G., see Weichman, B.

M., 295

y-Glutamyl transpeptidase, he-

patic, induction by aminopy-

rine (rats), 795Glutathione, acetaminophen-in-

duced depletion in kidney

(rats), 76

Glutathione transferase, effects of

butylated hydroxy-anisole

and tras.stillbene oxide on

(mice, rats), 242

Goodman, D. R., see James, R. C.,

708Goodman, R. P., see Jackson, E.

K., 183Gormezano, I., see Harvey, J. A.,

289

Gram, T. B., see Trush, M. A.,

152, 159

Gray, N. M., Lu, M. C. H. andBhargava, H. N.: The effectsof stereoisomers of 2- and 9-

aminobenzonobornenes on

food intake, brain serotonin

concentration and mono-

amine oxidase activity in the

rat, 58Gregus, Z. and Klaassen, C. D.:

Role of ligandin as a bindingprotein and as an enzyme in

the biliary excretion of sulfo-

bromophthalein, 242

Griffin, K. A., Johnson, C. B., Bre-

ger, R. K. and Franklin, R.

B.: Effects of inducers of cy-

tochrome P-450-linked mono-oxygenases on the toxicity, in

vitro metabolism and in vitoirreversible binding of 2-

methylnaphthalene in mice,

517Griffin, R. L., see Mao, P. B., 410Grund, V. R., see Cacini, W., 342

Guanabenz, renal effects of(dogs), 347

Guo, Z.-G., see Burke, J. A., 235

Haisch, K. D., see Fleisch, J. H.,

146

Hallucinogens, effects on classicalconditioning of nictitatingmembrane response (rab-bits), 289

Haloperidolactivation of retinal tyrosine

hydroxylase by (rats), 326

effects on dopamine and sero-

tonin metabolism in brain

(monkeys), 22pharmacokinetics, age effects

1982 Index 833

on (rats), 434

selective blockade of peripheraldopamine receptors (dogs),753

Harbison, R. D., see James, R. C.,708

Harbison, R D., see Wells, P. G.,228

Harmol, glucuronide, cholestasisby (rats), 731

Harris, R. A., see Sneil, D., 444Harvey, J. A., Gormezano, I. and

Cool, V. A.: Effects of d-lys-ergic acid diethylamide, d-2-

bromolysergic acid diethyl-amide, d-2,5-dimethoxy-4-methylamphetamine and d-

amphetamine on classicalconditioning of the rabbit

nictitating membrane re-

sponse, 289

Hassid, A., see Beck, T. R., 269

Hata, 5.-I., see Koide, T., 481Hatzinikolaou, P., see Charoco-

pos, F., 315

Heartbeta adrenoceptors, desensiti-

zation by catecholamines

(rats), 784conduction, ischemia, effect of

lidocaine (dogs), 353

development in newborn, ef-fects of dexamethasone(rats), 686

effects of propranolol on den-sity of beta adrenergic recep-

tors in (rats), 439

Purkinje fibers, effects of amri-none or oscillatory afterpo-tentials and aftercontractions(dogs), 188

sympathetic nerves, reutiiza-

tion of norepinephrine stor-

age vesicles in (guinea pigs),820

ventricular papillary muscle, ef-fects of leukotirenes C4, D4and B4 in vitro (man, guineapigs), 235

working, effect of reserpine pre-treatment on performance

and responsiveness to mo-tropic agents of, 721

Heart rate

effect of guanabenzon (dogs),

347

effect of nicotine on (man), 368

Heaslip, R. J. and Rahwan, R. G.:Evidence for the existence oftwo distinct pools of intracel-lular calcium in the rat aortaaccessible to mobilization by

norepinephnne, 7Hemodialysis, methylmercury,

mobilization and removal of

methylmercury with dimer-captosuccinic acid during(dogs), 63

Hemodynamic responses, differ-ent, after diuresis in normo-

tensive and hypertensivestate (rats), 315

Hemodynamics, liver, comparison

of vanadate and ouabain ef-

fects on (rats), 197Henderson, B. G., see Voile, R. L,

570

Henry, P. D., see Perez, J. E., 609

Herz, A., see Shearman, G. T., 735Hill, D. E., see Slikker, W., Jr.,

173

Hinman, D. J., see Aaronson, L.

M., 319Hirota, T., see Satoh, T., 795

Histamine

effect of reserpine pretreatment

on inotropic responsivenessof heart to, (guinea pigs), 721

-induced bronchoconstriction,

effects of nifedipine (dogs),410

Hjelle, J. J., see Peterson, D. R.,275

Hokin, L. E., see Marshall, P. J.,645

Hook, J. B., see Newton, J. F., 76

Horst, W. D., see Niehoff, D. L.,

670

Hostelly, L. S., see Weichman, B.M., 295

Hydantoin, fetal toxicity, stereo-selective, evaluation of me-

phenytoin and nirvanol

(mice), 22815-Hydroperoxyarachidonic acid-

induced contraction of basi-

lar artery, mechanisms of

(dogs), 4819-Hydroxyprostaglandin dehy-

drogenase, involvement in

conversion of prostaglandin12 to 6-keto-prostaglandin B,(man), 183

5-Hydroxytryptamine (see also

Serotonin)

antagonists, interactions with

lysergic acid diethylamine

(rats), 206Hypertension

effect of antiogensin II on

(rats), 112effect of furosemide on (rats),

315

Hypothalamus, inhibition by do-

pamine receptor agonists of

noradrenergic neurotrans-mission in (rabbits), 461

Igarashi, T., see Satoh, T., 795

Iieum

actions of dimaprit on hista-

mine H2 receptors on (guinea

pigs), 69

field-stimulated, degradation of

enkephalin in (guinea pigs),104

Imipramine-induced release of

creatine kinase and lactatedehydrogenase from skeletal

muscles (frogs), 489Indomethacin

effect on inflammatory re-

sponse to dextrans, cairo-

geenan and Compound 48/80(rats), 261

effects on adherence, chemo-taxis and accumulation ofpolymorphonuclear leuko-

cytes (rats), 701Inflammatory responses, to dex-

trans. comparison with car-rogeenan and Compound 48/

80 (rats), 261

Intestine, studies of drug metab-

olism in (dogs), 507

Ion channels, in electric organ mi-crosacs and myotubes, effectsof ketamine and ditran (ray,

chick), 570lonomycin, actions in parotid

gland (rats), 247

lonophore-induced contractions,

release of slow reacting sub-

stance of analphylaxis from

lung during (gunea pigs), 146

lonophores, carboxylic, inhibition

of catecholamine synthesis in

pheochromocytoma cells, 536

Iron adventitious, involvement in

bleomycin-mediated DNA

damage (rats), 159

Iron-chelating drugs, derived

from pyridoxal and its ana-

logs, in vito evaluation of

(rats), 399

Ishida, Y., see Ohizumi, Y., 748

Isoproterenol

effect of reserpine pretreatment

on inotropic responsiveness

of heart to (guinea pig), 721

effects on action potential du-

ration in papillary muscle

(guinea pigs), 806

Israel, A. S., Barbeila, Y. R. andCubeddu, L. X.: Effects ofchemical sympathectomy on

the increases in plasma cate-

cholamines and dopamine-fl-

hydroxylase induced by

forced-immobilization and

insulin-induced hypoglyce-

mia: Origin and fate of

plasma dopamine-/3-hydro-

sylene, 577Itoh, T., see Karashima, T., 472

Jackson, E. K., Goodman, R. P.,

Fitzgerald, G. A., Oates, J. A.,and Branch, R. A.: Assess-ment of the extent to whichexogenous prostaglandin L is

converted to 6-keto-prosta-

glandin E, in human subjects,

183

Jacob, III, N. L., see Benowitz, N.L., 368

James, T. N., see Schwartz, M.,801

James, R. C., Goodman, D. R. andHarbison, R. D.: Hepatic glu-tathione and hepatotoxicity:

Changes induced by selected

narcotics, 708

.Janson, V. E., see Sastry, B. V. R.,

629Janssen, P. A. J., see Colpaert, F.

C., 206

Johanson, C. E.: Behavior main-

tamed under fixed-interval

and second-order schedulesof cocaine or pentobarbital in

rhesus monkeys, 384

Johnson, C. B., see Griffin, K. A.,517

Johnson, D. K., Pippard, M. J.,Murphy, T. B. and Rose, N.J.: An in vito evaluation ofiron-cheLating drugs derived

from pyridoxal and it�s ana-

Logs, 399

Johnson, S. W. and Riker, W. K.:A comparative study of theeffects of phenytoin and phe-

nobarbital on electrically in-

duced maximal seizures in

frogs and mice, 132

Johnson, S. W., and Riker, W. K.:

Phenytoin antagonism of

electrically induced maximalseizures in frogs and mice and

effects on central nervous

system levels of adenosine

3’,S’-monophosphate and

guanosine 3’ ,5’ - monophos-

phate, 139Jones, D., see Ohlsson, A. E., 362.Jones, R. T. see Benowitz, N. L.,

368

Kalman, S. M., see Butler, V. P.,

Jr., 123Kapetanovic, I. M., Sweeney, D.

J. and Rapoport, S. I.: Ageeffects on haloperidolpharmacokinetics in maleFischer-344 rats, 434

Karashima, T., Itoh, T. and Ku-

riyama, H.: Effects of 2-ni-

cotinamidoethyl nitrate on

smooth muscle cells of the

guinea-pig mesenteric andportal veins, 472

Kawasaki, H., Cline, W. H., Jr.,and Sur, C.: Enhanced angio-tensin-mediated facilitation

of adrenergic neurotransmis-

sion in spontaneously hyper-

tensive rats, 112

Keith, R. A., Burkman, A. M.,Sokoloski, T. D. and Fertel,R. H.: Vascular tolerance tonitroglycerin and cylic GMPgeneration in rat aorticsmooth muscle, 525

Keller, M. B., see Cacini, W., 342

Katamine, effects on acetylcho-line receptors and ion chan-

nels in electric organ

microsacs and myotubes

(ray, chick), 570Khan, M. T. and Furchgott, R. F.:

Interactions of phenoxybenz-

amine and nicotinic agonists

at the nicotinic receptor in

the cat adrenal medullar, I 17Kidney

alpha-2 receptors, role in di-uretic effect of guanabenz

(dogs), 347

and liver failure, induced by tet-racycline after portacaval

shunt (dogs), 558

cortex slices, accumulation of

cimetidine by (dogs), 342cortical thick ascending limb of

Henle’s loop, inhibition ofcalcium absorption by furo-semide in (rabbits), 815

failure, effect on sulfate reten-

tion and acetaminophenpharmacokinetics (rats), 80

function, effects of N-ethylmal-

eimide and metabolites

(dogs), 623

834 Index

inner medulla slices, bradyki-mn-mediated prostaglandinB2 and cyclic GMP synthesesin (rabbit), 532

isolated perfused, metabolism

of acetaminophen by (rats),

76

medullary cyclooxygenase ac-

tivity, effect of 1-desamino-8-

D-arglnrne vasopressin (rats),269

medullary thick ascendinglimbs of Henle, effects ofMK-196 and furosemide on(rats), 715

possible involvement of throm-

boxane A2 in arachidonicacid-induced vasoconstric-tion in (rats), 614

slices, transport of riboflavin by

(rabbits), 394Kinetics (see also Pharmacoki-

netics)of enzyme-mediated metabo-

lism (dogs), 507of methyimercury (dogs), 63redox, of paraquat (rats), 428

Kisslinger,S. D.,seeWu,Z.-A. C.,664

Kitagawa, H., see Satoh, T., 795

Klaassen, C. D., see Gregus, Z.,242

Klein, R. M., see Chang, H. Y.,784

Kluwe, W. M., see Newton, J. F.,76

Knodell, R. G., Allen, R. C. andKyner, W. T.: Effects of eth-inyl estradiol on pharmaco-kinetics of meperidine andpentobarbital in the rat, 1

Knodell, R. G., Farleigh, R. M.,Steele, N. M. and Bond, J.H.: Effects ofliver congestionon hepatic drug metabolism

in the rat, 52

Koechel, D. A. and Rankin, G. 0.:Acute effects of alkylatingagents on canine renal func-tion: N-ethylmaleimide andsome of its potential bio-

transformation products,623

Koide, T., Neichi, T., Takato, M.,Matsushita, H., Sugioka, K.,Nakano, M. and Hats, S.-!.:Possible mechanisms of 15-hydroperoxyarachidonicacid-induced contraction ofthe canine basilar artery in

vitro, 481

Koster, H. J., see Krijgsheld, K.R., 731

Kostyniak, P. J.: Mobilization and

removal of methylmercury inthe dog during extracorporealcomplexing hemodialysiswith 2,3-dimercaptosuccinic

acid (DMSA), 63Kramer, P., see Denenberg, V. H.,

604

Krause, D. N., see Estrada, C., 85Krell, R. D., see Weichman, B.

M., 295

Krijghseld, K. R., Koster, H. J.,Scholtens, E. and Mulder, G.

J.: Cholestatic effect of har-mol glucuronide in the rat.Prevention of harmol-in-duced cholestasis by in-creased formation of harmolsulfate, 731

Kuhar, M. J., see Niehoff, D. L.,

670

Kunos, G., see Chang, H. Y., 784Kuo, C-H., see Newton, J. F., 76

K#{252}pfer, A., Desmond, P. V.,Schenker, S. and Branch, R.A.: Stereoselective metabo-lism and disposition of theenantiomers of mephinytoin

during chronic oral adminis-tration of the racemic drug inman, 590

K#{252}pfer,A., see Wells, P. G., 228Kuriyama, H., see Karashima, T.,

472

Kyner, W. T., see Knodell, R. G.,

Lactate dehydrogenase, releasefrom skeletal muscles in-

duced by imipramine (frogs),. 489

Lamanna, V., Antzelevitch, C. andMoe, G. K.: Effects of lido-caine on conduction throughdepolarized canine false ten-dons and on a model of re-flected reentry, 353

Lambert, J. J., see Volle, R. L.,570

Langer, S., see Galzin, A. M., 461Langer, S. Z., see Massingham, R.,

753

Larrey, D., see Pessayre, D., 215

Larsen, J. A., see Thomsen, 0. 0.,197

Lau, C., see Slotkin, T. A., 686Lawson, J. A., see Wells, P. G.,

228Legrum, W. and Frahseck, J.: Ac-

celeration of 7-[methoxy-’4C]coumarin-derived carbon di-oxide exhalation by cobaltpretreatment in mice, 790

Leslie, B. A., see Poggioli, J., 247Leukotrienes, C4 , D4 and E4, ef-

fects on cardiac preparationsin vitro (man, guinea pigs),235

Levamisole, effects on adherence,chemotaxis and accumula-tion of poiymorphonuclear

leukocytes (rats), 701

Levi, R, see Burke, J. A., 235Levy, G., see Lin, J. H., 80

Liang, B. T., see Vaccaro, K. K.,536

Lidocaine, effects on conductionthrough false tendons and onreflected reentry (dogs), 353

Ligandin, role as binding proteinand enzyme in biiary excre-tion of suifobromophthalein

(mice, rats), 242Lin, J. H. and Levy, G.: Effect of

experimental renal failure onsulfate retention and acet-aminophen pharmacokinet-

ics in rats, 80Lindenbaum, J., see Butler, V. P.,

Jr., 123Lindstrom, T. D., Murphy, P. J.,

Smallwood, J. K., Wiest, S.A. and Steinberg, M. I.: Cor-relation between the disposi-tion of [‘4C]clofihium and

its cardiac electrophysiologi-cal effect, 584

Lipoxygenase, stimulation, en-hancement by 15-hydrope-roxyarachidonic acid (dogs),

�481

Lisuride, role of dopamine and

serotonin in discriminative

stimulus effects of (rats), 421

Liver

and kidney failure, induced bytetracycline after portacaval

shunt (dogs), 558

congestion, effects on drug me-

tabolism by (rats), 52DNA damage, effects of cimet-

idine and sodium nitrite

(rats), 222

drug-metabolizing enzymes, ef-

fects of oleandomycin on

(rats), 215

y-glutamyl transferase, induc-

tion by aminopyrine (rats),

795

isolated perfused, effects of es-

trogen on pharmacokineticsof meperidine and pentobar-

bital in (rats), 1

microsomal ethanol oxidation,

increase by ethanol (mice),275

microsomal metabolism of es-

trogen, effects of thyroxineand estradiol (rats), 564

perfused, comparison of vana-date and ouabain effects on

hemodynamics and bile pro-

duction in (rats), 197studies of drug metabolism in

(dogs), 507

toxicity of narcotics (mice), 708Lo, M.-W., Effeney, D. J., Pond,

S. M., Silber, B. M. and Rie-

gelman, S.: Lack of gastroin-

testinal metabolism of pro-

pranolol in dogs after porta-caval transposition, 512

Lo, M.-W., see Effeney, D. J., 507

Lo, T. N., Almeida, A. P. and

Beaven, M. A.: Dextran and

carrageenan evoke differentinflammatory responses in

rat with respect to composi-

tion of infiltrates and effectof indomethacin, 261

Lu, M. C. H., see Gray, N. M., 58

Lung

effects of propranolol on den-

sity of beta adrenergic recep-tors in (rats), 439

isolated perfused, serotonin up-

take, depression by paraquat(rats), 254

microsomes, interaction with

bleomycin A2, characteriza-

tion of factors which influ-

ence bleomycin-mediated

DNA chain breakage (rats),152

microsomes, interaction with

Vol. 221

bleomycin A2, involvement ofiron and oxygen in bleomy-cm-mediated DNA chain

breakage (rats), 159

regulation of synthesis andrelease of SRS-A from (mon-

keys), 295

release of slow reacting sub-

stance of anaphylaxis during

antigen- or ionophore-in-duced contractions (guineapigs), 146

toxicity, of 2-methylnaphtha-

lene (mice), 517

Lungs, paraquat uptake and redox

kinetics in (rats), 428L#{252}thi,P., see Atkinson, J., 453

Lymphocytes, effects of propran-

olol on density of beta adre-nergic receptors in (rats), 439

d-Lysergic acid diethylamide, ef-fects on classical conditioning

of nictitating membrane re-

sponse (rabbits), 289Lysergic acid diethylamine, inter-

actions with 5-hydroxytryp-

tamine antagonists (rats), 206

Malveaus, E. J., see Faraj, B. A.,

558

Malo, P. E., Wasserman, M. A.

and Griffin, R. L.: Effects ofintravenous and aerosol nile-dipine on prostaglandin andhistamine-induced broncho-constriction in anesthetized

dogs, 410

Marks, B. H., see Anderson, G. F.,598

Marshall, P. J., Dixon, J. F. and

Hokin, L. B.: Prostaglandin

E2 derived from phosphati-

dylinositol breakdown in the

exocrine pancreas facilitatessecretion by an action on theducts, 645

Martin, B. R., see Ohisson, A. B.,362

Martin, B. H., see Tripathi, H. L.,91

Martinez, S., see Ackerman, N.,

701

Mashal, R. D., see Niehoff, D. L.,

670

Masserano, J. M., and Weiner, N.:Investigations into the neu-rochemical mechanisms me-

diating differences in ethanolsensitivity in two lines of

mice, 404

Massingham, R., see Shepperson,

NB., 753

Matsushita, H., see Koide, T., 481Maura, A., see Brambilla, G., 222Mclntire, S. L., see Roth, K. A.,

416McKinney, J. S., see Poggioli, Jr.,

247

McMillan, D. B. and Svoboda, A.C. IV: The role of erythro-cytes in cyanide detoxifica-

tion, 37McMillan, J. E., see Alderice, M.

T., 547

Meperidine, effects of estrogen onpharmacokinetics of (rats), 1

Mephenytoin

1982 Index 835

enantiomers, stereoselectivemetabolism and disposition.(man), 590

evaluation in stereoselective fe-tal hydantoin toxicity (mice),

228

Metabolismcyclic nucleotide, in ventricular

muscle, positive inotropic ef-fect of amrinone related to(dogs), 775

dopamine and serotonin, effectsof haloperidol and fluphena-zine (monkeys), 22

drug, effects of estrogen (rats),

drug, relation to stereoselectivefetal hydantoin toxicity

(mice), 228

drug, studies of hepatic and in-testinal (dogs), 507

gastrointestinal, of propranolol

after portacaval transports-

tion, lack of (dogs), 512

of acetaminophen by kidney

(rats), 76of estrogen (monkeys), 173

of 2-methylnaphthalene (mice),

517of morphine and pentobarbital,

effects of liver congestion

(rats), 52

of nicotine (man), 368

of oleandomycin (rats), 215of serotonin, noradrenergic

modulation (rats), 541

of thiocyanate, role of erythro-

cyte in (man), 37

stereoselective, of mephenytoin

enantiomers (man), 590

Metabolites, of N-ethylmaleim-

ide, effects on renal function(dogs), 623

Methacholine, inhibition of quin-uclidinyl benzilate binding to

pial blood vessel membranesby (cows), 85

L-Methionine-mediated mem-

brane phospholipid methyla-tion in diaphragm, relation-

ship to aging (rats), 629

Methionine-enkephalin, effect onnerve stimulation-mediatedrelease of norepinephrine anddopamine-f�-hydroxylase

(cats), 282Methionine-enkephalinamide, ef-

fect on distribution of radio-activity in spinal cord (mice),362

5-Methoxy-N,N-dimethyltrypta-

mine-induced head twitches,effects of mianserin on (rats,mice), 303

3-Methoxy-4-hydroxyphenylgly-

col, sulfate conjugation, Id-netics of (man), 43

3-Methylcholanthrene, effects onpulmonary toxicity and me-tabolism of 2-methylnaph-thalene (mice), 617

Methylene blue, effects on relax-ation � and cyclic GMP for-mationin aortic smooth mus-

cle (rats), 5251-Methyl-3-isobutylxsnthine, ef-

fects on bradykinin-mediatedproataglandin and cyclicGMP synthesis in renal inner

medullary slices (rabbits),532

Methylmercury, mobilization and

removal during extracorpo-real complexing hemodialysiswith dimercaptosuccinic acid(dogs), 63

2-Methylnaphthalene, toxicity,metabolism and irreversiblebinding of (mice), 517

Mianserin, effects on serotonin re-ceptor sites (rats, mice), 303

Microsomal ethanol oxidation,liver, increase by ethanol(mice), 275

Microsomes, liver, metabolism of

estrogen, effects of thyroxineand estradiol (rats), 564

Mimnaugh, B. G., see Trash, M.A., 152, 159

Mirkovich, A., see Ackerman, N.,701

MK-196, effects on medullarythick ascending limbs of

Henle (rats), 715

Moe, G. K., see Lamanna, V., 353Moises, H. C., see Waterhouse, B.

D., 495

Molinoff, P. B., see Aarons, R. D.,

439

Monesin, inhibition of catechol-amine synthesis in pheo-chomocytoma cells, 536

Monoamine oxidase activity,effects of stereoisomers of

aminobenzonorbornenes on

(rats), 58

Monooxygenases, cytochrome P-450 linked, role in toxicity,metabolism and irreversible

binding of 2-methylnaphtha-lene (mice), 517

Morphineantinociceptive action (mice),

362

effect on nerve stimulation-me-

diated release of norepineph-

rine and dopamine-$-hydrox-ylase (cats), 282

metabolism, effects of liver

congestion (rats), 52Motor activity, effects of naloxone

(rats), 444Muccitelli, R. M., see Weichman,

B. M., 295Mudge, G. H., see Newton, J. F.,

76

Mulder, G. J., see Krijgsheld, K.R., 731

Murphy, P. J., see Lindstrom, T.D., 584

Murphy, T. B., see Johnson, D.K., 399

Musclecells, smooth, of mesenteric and

portal veins, effects of 2-ni-cotinamidoethyl nitrate on(guinea pigs), 472

papillary, effects of isoprotere-nol on action potential dura-tion in (guinea pigs), 806

skeletal, contractions, effect ofamphetamine on (rats), 14

smooth, aortic, vascular toler-ance to nitroglycerine andyclic GMP generation in

(rats), 525

smooth, detrusor, cholinergic

receptors in (rabbits), 598

ventricular, positive inotropiceffect of amrinone related to

cyclic nucleotide metabolismin (dogs), 775

Muscles, skeletal, imipramine-in-duced release of creatine ki-nase and lactate dehydrogen-ase from (frogs), 489

Myocardial infarct size reduction,effect of tiapamil on (dogs),

29

Myocardiumblood flow, redistribution in-

duced by beta adrenoceptorblockade (dogs), 740

effects of leukotrienes C,, D4and B4 in vitro (man, guineapigs), 235

Nakano, M., see Koide, T., 481Naloxone, behavioral effects

(rats), 444

Narcotic antagonists, effects on

discriminative stimulus prop-

erties of fentanyl and ethyl-

ketocyclazocine (rats), 735

Narcotics, hepatotoxicity (mice),

708

Neff, N. H., see Cohen, J., 326

Neichi, T., see Koide, T., 481

Nephrotoxicity, of acetamino-

phen (rats), 76Nerve

cholinergic, in colonic mucosa

(rats), 664

sympathetic, cardiac, reutiiza-

tion of norepinephnne stor-

age vesicles in (guinea pigs),

820

Nervous system

central, amphetamine activity

in (rats), 58

central, dopamine receptor ag-

onists inhibit norepinephrine

release in (rabbits), 461

central, effects of phenytoin on

levels of cyclic AMP andcyclic GMP in (frogs, mice),139

beta adrenergic, interactionwith renin-angiotensin sys-

tern after renal artery con-stnction (rats), 453

Neuromuscular transmission,

comparison of effects of tri-methadione and dimetha-

dione on (frogs), 547

Neurons

ileum rnyenteric plexus, media-

tion of reiease of contractile

agents by histamine H2 re-ceptors on (guinea pigs), 69

noradrenergic, modulation ofserotonin synthesis and me-

tabolism by (rats), 541

Neurotransmissionadrenergic, mediation by pre-

synaptic angiotensin II recep-

tors (rats), 112adrenergic, peripheral, modu-

lation by methionine-en-kephalin (cats), 282

noradrenergic, in hypothala-mus, inhibition by dopaminereceptor agonists of (rabbits),461

Newborn, effects of dexametha-some on development ofbrain and heart (rats), 290

Newton, J. F., Braselton, W. E.,Jr., Kuo, C.-H., Kluwe, W.M., Gemborys, M. W.,Mudge, G. H. and Hook, J.B.: Metabolism of acetamin-ophen by the isolated per-fused kidney, 76

2-Nicotinamidoethyl nitrate, ef-

fects on smooth muscle cells

of mesenteric and portal

veins (guinea pigs), 472

Nicotine

effect on concentration andturnover of brain catechol-amines (rats), 416

-induced antinociception (rats,mice), 91

metabolism and cardiovasculareffects (man), 368

interaction with phenoxybenz-

amine at nicotinic receptor(cats), 117

Nictitating membrane, response,

effects of hallucinogens onclassical conditioning of (rab-bits), 289

Niehoff, D. L., Mashal, R. D.,

Horst, W. D., O’Brien, R. A.,Palacios, J. M. and Kuhar,

M. J.: Binding of a radiola-beied triazolopyridazine to asubtype of benzodiazepine re-ceptor in the rat cerebellum,670

Niemegeers, C. J. E., see Colpaert,F. C., 206

Nifedipine, effects on prostag-

iandin F2,,- and histamine-induced bronchoconstriction(dogs), 410

Nirvanol, evaluation in stereose-lective fetal hydantoin toxic-

ity (mice), 228

Nitroglycerin, vascular tolerance,

relationship to cyclic GMP

generation in aortic smoothmuscle (rats), 525

Nitroprusside, vascular tolerance,

relationship to cyclic GMP

generation in aortic smooth

muscle (rats), 525

Norepinephrineactivation of adrenoceptors

(rats), 762contractile effects in aorta, role

of intracellular calcium

(rats), 7effects of morphine and methi-

onine-enkephalin on nervestimulation-mediated releaseof (cats), 282

enhancement of inhibitory syn-

aptic mechanisms in cere-bellum and cerebral cortex(rats), 495

-induced acetylcholine release,effect of amphetamine on

836 Index

(rats), 14

release in central nervous sys-

tern, inhibition by dopamine-

receptor agonists (rabbits),461

storage vesicles in cardiac sym-

pathetic nerves, reutilization

(guinea pigs), 820

synthesis in brain synapto-somes, effect of i�9-tetrahy-

drocannabinol on (mice), 97Normotension, effect of furose-

mide on (rats), 315

Oates, J. A., see Jackson, E. K.,

183

O’Brien, R. A., see Niehoff, D. L.,

670

Ohizumi, Y., Ishida, Y. and Shi-

bata, S.: Mode of the cigua-

toxin-induced supersensitiv-ity in the guinea-pig vas def-

erens, 748

Ohlsson, A. B., Fu, T.-C., Jones,

D., Martin, B. R. and Dewey,

W. L.: Distribution of radio-activity in the spinal cord

after intracerebroventncuiar

and intravenous injection of

radiolabeled opioid peptides

in mice, 362Okamoto, M., see Aaronson, L.

M., 319

Oleandomycin, effects on hepaticdrug-metabolizing enzymes,

comparison with troleando-mycin (rats), 215

Ouabain, effects on hemodynam-

ics and bile production in

liver, comparison with vana-

date (rats), 197

Overton, D. A.: Multiple drugtraining as a method for in-

creasing the specificity of thedrug discrimination pro-

cedure, 166

Owens, L. K., see Sastry, B. V. R.,

629

Oxidation, of NADPH in lungs,paraquat-dependent (rats),

428

Oxygen, reactive, involvement in

bleomycin-mediated DNA

damage (rats), 159

Palacios, J. M., see Niehoff, D. L.,

670

Pancreas, enzyme secretion, facil-itation by prostaglandin E2

derived from phosphatidyli-

nositol breakdown (mice),

645

Paraquat, depression of serotonin

uptake by lungs exposed to

(rats), 254

l-Penbutolol-induced coronary

blood flow redistribution(dogs), 740

Penicillin, relationship to ribo-

flavin transport in renal slices

(rabbits), 394

Pentobarbital

behavior maintained under

fixed-interval and second-or-der schedules of delivery by

(monkeys), 384

effects of estrogen on pharma-

cokinetics of (rats), 1

metabolism, effects of liver

congestion (rats), 52

P#{233}ra-Bally, R., see Atkinson, J.,

453Perez, J. B., Borda, L., Schuch-

leib, R. and Henry, P. D.: mo-tropic and chronotropic ef-

fects of vasodilators, 609Pergolide, inhibition of norepi-

nephrine release in central

nervous system by (rabbits),

461

[‘HiPerhydrohistrionicotoxin,

binding, to nicotinic acetyl-

choline receptor (rats), 694Perlman, R. L., see Vaccaro, K.

K., 536Pessayre, D., Descatoire, V., Ti-

nel, M. and Larrey, D.: Self-induction by oleandomycin of

its own transformation into ametabolite forming an mac-

tive complex with reduced

cytochrome P-450. Compari-

son with troleandomycin, 215

Petersen, D. R., Atkinson, N. and

Hjelle, J. J.: Increase in he-patic microsomal ethanol ox-

idation by a single dose of

ethanol, 275

Peters-Haefeli, L., see Atkinson,N., 453

pH, altered, effects on actions ofdimethadione on neuromus-cular function (frogs), 547

Pharmacokineticshaloperidol, age effects on

(rats), 434

of acetaminophen, effect of

renal failure on (rats), 80

of dihydrodigoxin (rabbits,

man), 123transplacental, comparison of

17/3-estradioi and diethyistil-bestrol (monkeys), 173

Phencyciidine

binding to electric organ micro-

sacs and myotubes, effects ofketamine and ditran (ray,

chick), 570

and related compounds, intra-venous self-administration

(dogs), 637Phenobarbital

effects on electrically inducedmaximal seizures, compari-son with phenytoin (frogs,

mice), 132

effects on pulmonary toxicity,

metabolism and irreversible

binding of 2-methylnaphtha-

lene (mice), 517

vs. saline discrimination (rats),

166

Phenol, sulfate conjugation, ki-netics of (man), 43

Phenol sulfotransferase, platelet,thermostable and thermola-

bile forms, role of acetamin-

ophen and phenol (man), 43

Phenoxybenzamine, blockade ofnicotinic receptor (cats), 117

Phenytoin

antagonism of electrically in-

duced maximal seizures and

effects on central nervoussystem levels of cyclic AMP

and cyclic GMP (frogs, mice),

139

effects on electrically induced

maximal seizures, compari-son with phenobarbital

(frogs, mice), 132

Pheochrornocytorna, cells, mone-

sin-inhibited catecholamine

synthesis in, 536

Philipps, A. F., see Denenberg, V.

H., 604Phosphatidylinositol, breakdown

to prostaglandin E2, faciita-

tion of pancreatic enzyme Se-cretion by (mice), 645

Phospholipid, methylation, L-

methionine-mediated, in

diaphragm, relation to

aging (mice), 629

Pino, A., see Brambilla, G., 222

Piperonyl butoxide, effects on

pulmonary toxicity, metabo-lism and irreversible binding

of 2-methylnaphthalene

(mice), 517

Pippard, M. J., see Johnson, D.K., 399

Pirenperone, antagonism of lys-

ergic acid diethylamine by

(rats), 206

Plasma, catecholarnines and

d o pamine-/3-hydroxylase,

effects of stress (guinea pigs),

577Pneumocytes, granular, paraquat

uptake and redox kinetics of

(rats), 428

Poggioli, J., Leslie, B. A., Mc-Kinney, J. S., Weiss, S. J. andPutney, J. W., Jr.: Actions ofionomycin in rat parotid

giand, 247

Polyrnorphonuclear leukocytes,

adherence, chemotaxis and

accumulation at inflamma-

tory site (rats), 701

Pond, S. M., see Effeney, D. J.,

507

Pond, S. M., see Lo, M.-W., 512

Portacaval anastomosis, hepato-

renal failure induced by tet-

racycline after (dogs), 558Portacaval transposition, lack of

gastrintestinal metabolism of

propranolol after (dogs), 512

Posner, M. A., see Forman, N. J.,428

Potential (see specific name)

action, in myocardium Purkinje

fibers, effects of amrinone on

(dogs), 188

Prazocin, negative chronotropiceffect on sinus node (dogs),

801

Preibisz, J. J., see Butler, V. P.,Jr., 123

Procainamide, antiarrhythmic ac-

tivity (rats), 552

Propranolol

effects on density of beta adre-nergic receptors (rats), 439

gastrointestinal metabolism

after portacaval transposi-

Vol. 221

tion, lack of (dogs), 512

N,N -di-n-Propyl -dopamine,selective blockage of periph-

eral dopamine receptors

(dogs), 753

Prostaglandin

B2, derived from phosphati-

dylinositol breakdown,

facilitation of pancreatic en-

zyme secretion by, 645

E2 synthesis in renal inner me-

dulls slices, mediated by

bradykinin (rabbits), 532F2-induced bronchoconstric-

tion, effects of nifedipine

(dogs), 410

12 , conversion to 6-keto-prosta-

glandin E, (man), 183

involvement in antidiuretic

hormone section (dogs), 347

6-keto-E, , conversion of pros-

taglandin 12 to (man), 183Pulmonary endothelium, effect of

paraquat (rats), 254Purkinje fibers

correlation between disposition

of [‘4C]ciofilium and electro-physiological effects in (rats,

dogs), 584

heart, effects of amrinone on

oscillatory afterpotentials

and aftercontractions (dogs),

188

Putney, J. W., Jr., see Poggioii, J.,247

Pyridoxal, evaluation of iron-che-

lating drugs derived from

(rats), 399

Quinuclidinyl benzilate, binding

to pial blood vessel mem-

branes, inhibition by cholin-

ergic agonists and antago-

nists (cows), 85

Radioirnrnunoassay, of dihydro-

digoxin, development and ap-

plication of (rabbits, man),

123

Rahwan, R. G., see Heaslip, R. J.,

7

Rankin, G. 0., see Koechel, D. A.,

623

Rapoport, S. I., see Kapetanovic,

I. M., 434Rapp, N. S., see Zenser, T. V., 532

Raye, J. R., see Denenberg, V. H.,604

Receptor

acetylchoiine, in electric organ

microsacs and myotubes, ef-fects of ketamine and ditran

(ray, chick), 570

adrenergic (see Adrenergic re-ceptor)

benzodiazepine, in cerebellum,

binding of triazolopyridazine

to (rats), 670

dopamine, agonists, inhibition

of noradrenergic neurotrans-

mission in hypothalamus by(rabbits), 461

nicotinic, in adrenal gland,

blockade by phenoxybenz-

amine (cats), 117

prostaglandin B,, -mediated cy-

1982 Index 837

clic AMP formation (clone),

334

sites, serotonin, effects of mian-

serin (rats, mice), 303

Receptorsalpha adrenergic, in aorta, ef-

fects of clonidine and yohim-

bine on (rats, guinea pigs,rabbits, hamsters, dogs, cats),309

alpha-2, kidney, role in diuretic

effect of guanabenz (dogs),347

beta adrenergic, effects of pro-pranolol on density of (rats),439

beta, adrenergic, mediation of

norepinephrine enhance-ment of inhibitory synaptic

mechanisms in cerebellum

and cerebral cortex (rats), 495brain, opiate, effects of nalox-

one and food deprivation(rats), 444

cholinergic, in urinary bladder(rabbits), 598

cholinergic, muscarinic, brain,effects of nicotine (rats), 416

dopamine, peripheral, selectiveblockade by dopamine recep-

tor antagonists (dogs), 753

doparninergic, striatal, rolein amphetamine-inducedbehavioral facilitation (rats),650

histamine H2, on ileum, actionsof dimaprit on (guinea pigs),

69

muscarinic cholinergic, bindingin cerebral blood vessels

(cows), 85

nicotinic acethycholine, desen-sitization (ray), 694

opiate, possible mediation ofnarcotic discrimination

(rats), 735

presynaptic angiotensin II, me-

diation of adrenergic neuro-transmission (rats), I 12

Redmond, D. E., Jr., see Bacopou-los, N. G., 22

Reentry, reflected, effects of lido-caine on (dogs), 353

Reinhard, J. F., Jr. and Roth, R.H.: Noradrenergic modula-tion of serotonin synthesis

and metabolism. I. Inhibitionby clonidine in vivo, 541

Reiter, C. andWeinshilboum, R.M.: Acetaminophen andphenol: Substrates for both athermostabie and a thermo-

labile form of human plateletphenol sulfotransferase, 43

Renin-angiotensin system, inter-

action with beta adrenergic

nervous systems after renal

artery constriction (rats), 453Reserpine

effect on differences in sensitiv-

ity of catecholamine neu-

ronal systems (mice), 404pretreatment, effect on ventnc-

ular performance and respon-siveness to inotropic agents

(guinea pigs), 721

Retina, activation of tyrosine hy-droxylase by haloperidol in(rats), 326

Reynolds, L. S., see Voile, R. L.,570

Riboflavin, transport by renalslices, relationship to cyclic

organic acid transport (rab-

bits), 394

Ricci, R., see Brambilla, G., 222

Richelson, E., see Sternstrom, S.,334

Riegelman, S., see Effeney, D. J.,

507

Riegelrnan, S., see Lo, M.-W., 512

Riker, W. K., see Johnson, S. W.,132, 139

Risner, M. E.: Intravenous self-administration of phencycli-

dine and related compoundsin the dog, 637

Robbiano, L., see Brambilla, G.,222

Roden, D. M., Duff, H. J., Alten-bern, D. D. and Woosley, R.L.: Antiarrhythmic activity ofthe 0-demethyl metabolite of

encainide, 552Rodgers, R. L. and McNeil, J. H.:

Effect of reserpine pretreat-ment on guinea-pig ventricu-

lar performance and respon-siveness to isotropic agents,721

Rose, N. J., see Johnson, D. K.,399

Rosenberg, J., see Benowitz, W.

L., 368

Rosenthal, J. B. and Ferrier, G.R.: Inotropic and electro-physiologic effects of amri-none in untreated and digi-talized ventricular tissues,188

Roth, K. A., Mclntire, S. L. and

Barchas, J. D.: Nicotinic-ca-techolaminergic interactions

in rat brain: Evidence forcholinergic nicotinic and

muscarinic interactions with

hypothalamic epinephrine,

416

Roth, R. H., see Bacopoulos, N.G., 22

Roth, R. H., see Reinhard, J. F.,Jr., 541

Rowe, J. C., see Denenberg, V. H.,604

Ruffolo, R. R., Jr., Waddeil, J. E.and Yaden, E. L.: Heteroge-

neity of postsynaptic alpha

adrenergic receptors in mam-malian aortas, 309

Rund, D. G., see Butler, V. P., Jr.,123

Saini, R. K. and Antonaccio, M.J.: Antiarrhythmic, antifibril-latory activities and reduc-

tion of infarct size after the

calcium antagonist Ro 11-1781 (tiapami) in anesthe-

tired dogs, 29Sakr, H. M. and Dunham, E. W.:

Mechanism of arachidonic

acid-induced vasoconstric-

tion in the intact rat kidney:

possible involvement of

thromboxane A,, 614Saline, vs. phenobarbital discrirn-

ination (rats), 166

Sanders-Bush, E., see Blackshear,

M. A., 303

Sastry, B. V. R., Owens, L. K. and

Janson, V. B.: Enhancementof the responsiveness of the

rat diaphragm by L-methio-

nine and phospholipid meth-ylation and their relation-ships to aging, 629

Satoh, T., Igarashi, T., Hirota, T.

and Kitagawa, H.: Inductionof hepatic y-glutamyl trans-

peptidase in rats by repeated

administration of aminopy-

rime, 795Scammell, J. G., see Shiverick, K.

T., 564

Schenker, S., see K#{252}pfer,A., 590

Schoen, F. J., see Block, E. R., 254

Scholtens, E., see Krijgsheld, K.R., 731

Schuchleib, R., see Perez, J. E.,609

Schwab, M., see Wakade, A. R.,820

Schwartz, M., Urthaler, F. andJames, T. N.: The direct neg-ative chronotropic action of

prazosin on the canine sinus

node, 801

Scott, W. L., see Geary, L. E., 104Secretion

of antidiuretic hormone, adre-noceptor effects and prosta-

glandin involvement (dogs),347

of protein, parotid gland, effect

of ionomycin (rats), 247

Seidler, F. J., see Slotkin, T. A.,686

Seizures

maximal, electrically induced,antagonism by phenytoin

(frogs, mice), 139

maximal, electrically induced,comparison of effects ofphenytoin and phenobarbitslon (frogs, mice), 132

Serotonin (see also 5-Hydroxy-tryptarnine)

brain, effects of stereoisomersof aminobenzonorbornenes

on (rats), 58receptor sites, effects of mian-

serin (rats, mice), 303role in discriminative stimulus

effects of lisuride (rats), 421synthesis and metabolism, nor-

adrenergic modulation (rats),541

Sheard, B. B., see Vaccaro, K. K.,536

Shearman, G. T. and Hera, A.:Evidence that the discrimi-native stimulus properties of

fentanyl and ethylketocyclaz-ocine are mediated by an in-

teraction with different opi-

ate receptors, 735Shepperson, N. B., Duval, N.,

Massingham, R. and Langer,S. Z.: Differential blocking ef-

fects of several dopamine re-

ceptor antagonists for periph-eral pre- and postsynaptic do-pamine receptors in the anes-

thetized dog, 753Shibata, S., see Ohizumi, Y., 748

Shiverick, K. T., Delorme, A. M.,Scammell, J. G. and Fregly,M. J.: Effects of chronictreatment with thyroxine and

estradiol on estrogen concen-

tration in serum and on he-patic microsomal catechol es-trogen formation in femalerats, 564

Silber, B. M., see Effeney, D. J.,507

Silber, B. M., see Lo, M.-W., 512

Sinus node, negative chronotropic

effect of prazocin on (dogs),

801

SKF 525A, effects on pulmonarytoxicity, metabolism and ir-

reversible binding of 2-meth-ylnaphthalene (mice), 517

Sleep, active, development innewborn, effects of theophyl-line (rabbits), 604

Sleep time, long and short, differ-ences in response to ethanol

(mice), 404

Slikker, W., Jr., Hill, D. E. and

Young, J. F.: Comparison oftransplacental pharmacoki-netics of 17$-estradiol and di-ethylstilbestrol in the subhu-

man primate, 173Slotkin, T. A., Barnes, G., Lsu, C.,

Seidler, F. J., Trepanier, P.,

Weigel, S. J. and Whitmore,W. L.: Development of poly-amine and biogenic aminesystems in brains and heartsof neonatal rats given dexa-

methasone: Role of biochem-ical alterations in cellular

maturation for producingdeficits in ontogeny of neu-

rotransmitter levels, uptake,

storage and turnover, 686

Smallwood, J. K., see Lindstrom,T. D., 584

Smilowitz, H., see VoIle, R. L., 570Smooth muscle (see Muscle,

smooth)Snell, D., Feller, D., Bylund, D.

and Harris, R. A.: Sensitiza-tion produced by repeated

administration of naloxone isblocked by food deprivation,444

Snider, R. M. and Gerald, M. C.:Studies on the mechanism of(+)-amphetamine enhance-

ment of neuromuscular

transmission: Muscle con-

traction, electrophysical and

biochemical results, 14Sodium nitrate, effect on DNA

damage in liver (rats), 222Sokoloski, T. D., see Keith, R. A.,

525

Spaethe, S. M., see Fleisch, J. H.,

146

838 Index Vol. 221

Spector, R.: Riboflavin transport

by rabbit kidney slices: Char-

acterization and relation tocyclic organic acid transport,

394Spinal cord, distribution of radio-

activity in, effects of opioid

peptides (mice), 362

Spleen, isolated perfused, effectsof morphine and methionine-enkephalin on release of nor-epinephrine and dopamine-fl-hydroxylase in (cats), 282

SRS-Aregulation of synthesis and

release from lung (monkeys),295

release from lung during anti-gen- or ionophore-inducedcontractions (guinea pigs),146

Stacciarini, W. M., see Faraj, B.A., 558

Steele, N. M., see Knodell, R. G.,52

Steinberg, M. I., see Lindstrom,T. D., 584

Stenstrom, S. and Richelson, B.:

Acute effect of ethanol onprostaglandin E,-mediated

cyclic AMP formation by a

murine neuroblastoma clone,334

trans-Stilbene oxide, effect on

glutathione transferase (mice,

rats), 242Stimulation, of splenic nerves, ef-

fects of morphine and methi-onine-enkephalin on releaseof norepinephrine and do-

pamine-/3- hydroxylase after(cats), 282

Stoner, L. C. and Trimble, M. B.:Effects of MK-196 and furo-

semide on rat meduilarythick ascending limbs of

henle in vitro, 715

Strandhoy, J. W., Morris, M. andBuckalew, V. M., Jr.: Real ef-fects of the antihypertensive,guanabenz, in the dog, 347

Stress, effects on plasma cate-

cholamines and dopamine-f1-hydroxylase (guinea pigs),577

Striatum, dopaminergic recep-

tars, role in amphetamine-in-

duced behavioral function(rats), 650

ST-segment mapping, effect of

tiapamil on (dogs), 29Su,C.,seeKawasaki,H., 112

Suarez-Kurtz, G. and Eastwood,A. B.: Release of creatine ki-nase and lactate dehydrogen-

ase from frog skeletal musclestreated with imipramine, 489

Sugioka, K., see Koide, T., 481Sulfate

prevention of harmol glucu-

ronide cholestasis by (rats),

731

retention, effect of renal failureon (rats), 80

Sulfate conjugation, of substrates,

kinetics of (man), 43

Sulfobromophthalein, role of ii-gandin in biliary excretion of

(mice, rats), 242R- and S-Sulpiride, selective

blockade of peripheral dopa-mine receptors (dogs), 753

Sunshine, I. see Van DeGraaff, W.B., 656

Superoxide dismutase, effect onparaquat-induced depressionof serotonin uptake in lungs

(rats), 254

Supersensitivity

ciguatoxin-induced, in vas def-erens (guinea pig), 748

inoptropic, reserpine-induced(guinea pigs), 721

Sved, A. F., Van Itallie, C. M. and

Fernstrom, J. D.: Studies on

the antihypertensive action

of L-tryptophan, 329

Svobodar, A. C. IV, see McMillan,D. B., 37

Sweeney, D. J., see Kapetanovic,

I. M., 434

Synaptosomes, brain, effect of s”-tetrahydrocannabinol onsynthesis of dopamine and

norepinephrine in (mice), 97

Taira, N., see Endoh, M., 775Takato, M., see Koide, T., 481

Temperature, skin, effects of nic-otine (mice), 368

Tetracycline-induced hepatorenalfailure after portacaval shunt(dogs), 558

Tewes, P. A. and Fischman, M.W.: Effects of d-amphet-amine and diazepam on fixed-interval, fixed-ratio respond-

ing in humans, 373

Theophylline, effects on behav-ioral state development in

newborn (rabbts), 604Thieme, T., see Ackerman, N., 701Thiocyanate, metabolism, role of

erythrocyte in (man), 37

Thiorphan, role in degradation ofenkephalin in ileurn (guineapigs), 104

Thoman, B. B., see Denenberg, V.H., 604

Thompson, W. L., see Van De-Graaff, W. B., 656

Thomsen, 0. 0. and Larsen, J. A.:Comparison of vanadate andouabain effects on liver he-modynamics and bile produc

tion in the perfused rat liver,197

Thromboxane A2, possible in-volvement in arachidonic

acid-induced vasoconstric-

tion in kidney (rats), 614

Thyroxine, effects on hepatic mi-crosomal metabolism of es-trogen (rats), 564

Tiapamil, antiarrhythmic, antifi-bnillatory activities and re-duction of infarct size by

(dogs), 29

Timmermans, P. B. M. W. M., see

Wilffert, B., 762

Tinel, M., see Pessayre, D., 215Tissues, ventricular, untreated

and digitalized, isotropic andelectrophysiologic effects of

amrinone in (dogs), 188

Toleranceof retinal system to neuroleptic

drugs (rats), 326vascular to nitroglycerin, rela-

tionship to cyclic GMP gen-

eration in aortic smooth mus-cle (rats), 525

Toxicity

hydantoin, fetal, stereoselec-tive, evaluation of mepheny-tom and nirvanol (mice), 228

of paraquat (rats), 428pulmonary, of 2-methyl-

naphthalene (mice), 517Transmission, neuromuscular, en-

hancement by amphetamine(rats), 14

Transportof riboflavin by renal slices, re-

latonship to cyclic organic

acid transport (rabbit), 394

renal, of cimetidine (dogs), 342

Trepanier, P., see Slotkin, T. A.,686

Triazoiopyridazines, binding to

benzodiazepine receptor in

cerebellum (rats), 670Trimble, M. B., see Stoner, L. C.,

715

Trirnethadione, effects on neuro-muscular function, compari-

son with dimethadone (frogs),547

Tripathi, H. L, Martin, B. R and

Aceto, M. D.: Nicotine-in-

duced antinociception in rats

and mice: Correlation withnicotine brain levels, 91

Troleandomycin, comparisonwith oleandomycin of effects on

hepatic drug-metabolizing

enzymes (rats), 215

Trush, M. A., Mimnaugh, B. G.,Ginsburg, B. and Gram, T. B.:

Studies on the interaction of

bleomycin A2 with rat lung

microsomes: I. Characteriza-tion of factors which in-

fluence bleomycin-mediatedDNA chain breakage, 152

Trush, M. A., Mimnaugh, B. G.,

Ginsburg, E. and Gram, T. E.:Studies on the interaction of

bleomycin A2 with rat lungmicrosomes: II. Involvement

of adventitious iron and re-

active oxygen in bleomycin-mediated DNA chain break-age, 159

L-Tryptophan, studies on antihy-

pertensive action of (rats),329

Tse-Eng, D., see Butler, V. P., Jr.,123

Tyrosine hydroxylasein brain, effects of haloperidol

and fluphenazine (monkeys),22

retinal, activation by halopen-

dol (rats), 326Tyrosine 3-monooxygenase, inhi-

bition by monesin in pheo-chromocytoma cells, 536

Uptake

dopamine, inhibition, relation-ship to bupropion disposition

(rats, mice), 676of cirnetidine by renal cortex

slices (dogs), 342

of �‘Na, stimulation by iono-

mycin (rats), 247

of paraquat (rats), 428of tyrosine, inhibition by

�s � tetrahydrocannabinol(mice), 97

serotonin, depression by lungs

exposed to paraquat (rats),254

Uretsky, N. J., see Conway, P. G.,650

Urinary bladder, cholinergic re-ceptors in (rabbits), 598

Urthaler, F., see Schwartz, M., 801

Vaccaro, K. K., Liang, B. T.,Sheard, B. D. and Perlman,

R. L.: Monensin inhibitscatecholamine synthesis in

pheochromocytoma cells, 536

Vanadate, effects on hemodynam-

ics and bile production in

liver, comparison with oua-

bain (rats), 197Van DeGraaff, W. B., Thompson,

W. L., Sunshine, I., Fretthold,D., Fredrich, L. and Dayton,H.: Adsorbent and catharticinhibition of enteral drug ab-

sorption, 656

Van Itallie, C. M., see Sved, A. F.,

329Van Zwieten, P. A., see Wilffert,

B., 762

Vascular bed, perfused mesen-

teric, effect of angiotensin II

(rats), 112

Vascular system, extrasynaptic lo-cation of alpha-2 and beta

andrenoceptors in (rats),762

Vas deferens, ciguatoxin-induced

supersensitivity in (guinea

pigs), 748

Vasoconstrictionarachidonic acid-induced, in

kidney, possible involvementof thromboxane A2 (rats),614

hepatic, induced by vanadate

and ouabain (rats), 197

Vasodilators, inotropic and chron-otropic effects (guinea pigs),

609

Veins, mesenteric and portal, ef-

fects of 2-nicotinamidoethyl

nitrate on smooth muscle

cells of (guinea pigs), 472

VoIle, R. L., Alkadhi, K. A., Bran-isteanu, D. D., Reynolds, L.S., Epstein, P. M., Srniowitz,H., Lambert, �J. J. and Hen-demon, B. G.: Ketarnine andditran block end-plate ion

conductance and [Hiphency-clidine binding to electric or-

gan membrane, 570

Vurek, G. G., see Bourdeau, J. E.,815

1982

Waddeil, J. B., see Ruffolo, R. R.,Jr., 309

Wakade, A. R., Wakade, T. D. andSchwab, M.: Epinephrine asa tool to investigate the ques-tion of recycling of sympa-

thetic storage vesicles in theheart: Chemical and morpho-logical studies, 820

Wakade, T. D., see Wakade, A.R., 820

Wasserman, M. A., see Malo, P.

B., 410

Waterhouse, B. D., Moises, H. C.,Yeh, H. H. and Woodward,D. J.: Norepinephrine en-hancement of inhibitory syn-aptic mechanisms in cerebel-lum and cerebral cortex: Me-diation by beta adrenergic re-ceptors, 495

Weichman, B. M., Hosteiley, L.S., Bostick, S. P., Mucciteili,R. M., Krell, R. D. and Glea-

son, J. G.: Regulation of thesynthesis and release of slow-reacting substance of ana-phylaxis from sensitizedmonkey lung, 295

Weigel, S. J., see Slotkin, T. A.,686

Weiner, N., see Masserano, J. M.,404

Weinshilboum, R. M., see Reiter,C., 43

Weiss, S. J., see Poggioli, J., 247

Welch, R. M., see Butz, R. F., 676

Wells, P. G., K#{252}pfer,A., Lawson,J. A. and Harbison, R. D.:Relation of in vivo drug me-tabolism to stereoselective fe-tal hydantoin toxicology in

mouse: Evaluation of me-

phenytoin and its metabolite,

nirvanol, 228White, F. J. and Appel, J. B.: The

role of dopamine and sero-

tonin in the discriminative

stimulus effects of lisuride,421

Whitmore, W. L., see Slotkin, T.. A.,686

Wiest, S. A., see Lindstrom, T. D.,584

Wiley, K. S., see Geary, L. B., 104

Wilffert, B., Timmermans, P. B.M. W. M. and Van Zwieten,P. A.: Extrasynaptic locationof alpha-2 and nomnner-vated beta-2 adrenoceptors

in the vascular system of the

pithed normotensive rat, 762Wissel, P. 5., see Butler, V. P., Jr.,

123Woodward, D. J., see Waterhouse,

B. D., 495Woosley, R. L., see Roden, D. M.,

552

Wu, Z.-A. C., Kisslinger, S. D. andGaginella, T. S.: Functional

evidence for the presence ofcholinergic nerve endings in

Index 839

the colonic mucosa of the rat,664

Yaden, B. L., see Ruffolo, R. R.,Jr., 309

Yamashita, S., see Endoh, M., 775

Yeh, H. H., see Waterhouse, B.

D., 495

Yohimbine, effect on alpha adre-nergic receptors in aorta(rats, guinea pigs, rabbits,

hamsters, dogs, cats), 309

Young, J. F., see Slikker, W., Jr.,

173

Zeidner, L. P., see Denenberg, V.H., 604

Zenser, T. V., Rapp, N. S. andI)avis, B. B.: Independentmechanisms for bradykinin-

mediated prostaglandin E2and cyclic GMP syntheses inrabbit renal inner medullaslices, 532