Keyword Index

3-D Culture, 104, 266, 323, 442, 729, 776, 780, 7953.0T, 423Accuracy, 444, 687Acetaminophen, 81Activities of Daily Living, 221, 481, 539, 575, 585,

630Adamts-5, 161, 473, 751African-Americans, 615, 623, 637Aggrecan, 161, 260, 375, 473, 69Aggrecan Gene Expression 133Aggrecanase 128, 787Aging 101, 107, 109, 11, 121, 237, 284, 298, 4, 429,

482, 500, 501, 511, 542, 638, 7, 767Alignment 311, 362, 709Anabolism 114, 45Analysis 453Animal Model 102, 143, 156, 167, 180, 186, 187, 2,

277, 279, 299, 317, 320, 375, 376, 4, 41, 434, 443,504, 514, 515, 70, 720, 730, 733, 734, 762, 768,782, 85

Ankle 163, 591, 597, 619, 694Anterior Cruciate Ligament 231, 242, 257, 292, 296,

318, 329, 331, 335, 336, 337, 339, 352, 357, 395,424, 434, 451, 47, 470, 516, 519, 579, 696, 734

Antioxidant 101, 107, 138, 43, 488Apoptosis 103, 144, 72, 73Architecture 253Arhroplasty 612, 614, 637, 652, 655, 660, 693, 711Arthritis 103, 146, 159, 190, 206, 214, 230, 276, 291,

292, 307, 315, 398, 402, 403, 407, 453, 494, 509,52, 535, 6, 605, 62, 643, 644, 666, 674, 686, 81, I-2

Arthroscopic Surgery 332, 702Arthroscopy 424, 510, 656Articular Cartilage 108, 115, 119, 129, 138, 14, 22,

261, 262, 267, 269, 282, 284, 286, 288, 289, 298,301, 308, 310, 369, 386, 41, 472, 494, 497, 499,505, 556, 56, 576, 58, 67, 676, 705, 715, 73, 756,762, 770, 771, 774, 787, 788, I-12, I-2

Articular Chondrocyte 105, 106, 112, 136, 140, 152,162, 191, 266, 30, 462, 496, 56

Articular Surface 271Autologous Chondrocytes Implantation 793Automated Segmetnation 445, 450beta1 Integrin 522Biochemical Marker 461, 466, 474, 485, 489, 68Biomarker 166, 184, 188, 212, 268, 292, 33, 381,

385, 40, 425, 429, 438, 462, 465, 467, 469, 470,471, 472, 473, 475, 476, 477, 478, 479, 481, 487,488, 49, 490, 50, 506, 607, 64, 647, 65, 66, 67,678, 699, 706, 8

Biomechanical Pressure 256, 271, 381Biomechanics 132, 268, 269, 276, 305, 33, 335, 336,

339, 340, 342, 348, 349, 351, 355, 357, 358, 360,361, 367, 370, 373, 464, 609, 63, I-15

Biopsies 442Bisphosphonate 721, 91BMI 542, 596

BMP-2 119, 141BMP-7 114, 45Body Composition 583, 590Bone 147, 264, 278, 319, 32, 322, 395, 423, 46, 499,

791, I-14Bone Marrow Edema 175, 194, 385, 394, 426, 564,

91Bone Mineral Density 148, 253, 542, 596Boundary Lubrication 271, 369Calcium 127, 130, 131, 135Canine 379, 86Cartilage 1, 10, 102, 109, 111, 137, 142, 143, 144,

161, 199, 2, 255, 265, 273, 275, 285, 29, 302, 312,313, 314, 325, 36, 387, 414, 420, 424, 450, 474,477, 49, 492, 495, 498, 500, 505, 509, 529, 55,641, 727, 730, 763, 84, 91, I-10, I-17, I-3, I-7

Cartilage Biology 100, 101, 105, 106, 112, 113, 116,123, 127, 28, 321, 462, 65, 72, 742, 775

Cartilage Biomarkers 307, 357, 400, 461, 486, 491,497, 680, 69, 744, 779

Cartilage Biomechanics 267Cartilage Contact Areas 370Cartilage Damage 110, 126, 167, 255, 274, 306, 332,

385, 387, 405, 417, 434, 436, 463, 47, 482, 50,676, 72, 720, 739, I-11

Cartilage Defect 22, 456, 755, 758, 85Cartilage Degeneration 103, 11, 121, 124, 13, 253,

258, 276, 281, 3, 311, 317, 319, 328, 331, 350,375, 386, 394, 40, 418, 459, 496, 713, 733, 74, 75,768, 773, 786, I-2

Cartilage Degrading Enzymes 104, 128, 263, 75, 94Cartilage Erosion 279Cartilage Explant 259, 280, 472Cartilage Matrix 258, 262, 268, 458, 715, 768Cartilage Mechanics 269Cartilage Morphology 258, 32, 400, 404, 410Cartilage Oligomeric Matrix Protein (COMP) 126,

129, 464Cartilage Protective 106, 192, 260, 267, 276, 277, 28,

515, 730, 83Cartilage Regeneration 120, 14, 149, 24, 288, 298,

300, 369, 460, 592, 758, 760, 761, 774, 776, 778,779, 781, 785, 788, 790, 791, 792

Cartilage Repair 119, 139, 25, 26, 321, 770, 783, 784,785

Cartilage Segmentation 419, 445Cartilage Thickness 310, 383, 417, 445, 571, 64, 83Cartilage Volume Measurements 310, 338Catabolic 45CD44 134, 777Cell Cycle 14, 482Cell Signaling 100, 106, 107, 121, 127, 130, 28, 44Chemokines 765, 766Chondrocyte 107, 11, 110, 118, 122, 123, 124, 127,

131, 139, 153, 165, 169, 171, 172, 174, 193, 262,29, 297, 3, 302, 314, 315, 316, 321, 42, 503, 511,

712, 713, 72, 738, 74, 743, 753, 760, 764, 775,780, 793, 794, 84

Chondrocyte Development 24Chondrocyte Metabolism 162, 263, 289, 323, 714,

I-12Chondrocyte Phenotyping 116, 312, 512Chondrogenesis 120, 130, 131, 132, 133, 135, 141,

154, 25, 26, 460, 502, 755, 757, 771, 778, 788,789, 795

Chondroitin Sulfate 260, 270, 304, 671Chondroprotection 128, 136, 143, 164, 172, 44, 671,

83Chromatin 492Classification 454, 560, 6Clinical Characteristics 215, 238, 506, 528, 533, 553,

566, 616, 644, 683, 80Clinical Study 222, 223, 225, 247, 351, 525, 538, 543,

562, 681, 683, 695, 706, 77, 88Clinical Trial 197, 217, 248, 522, 526, 527, 530, 536,

547, 549, 556, 60, 686, 69, 719, 725, 737, 741,744, 749, 759, 781, 796, 9, 91, I-15

Clinical-Radiological Correlations 683Co-Morbidity 205, 523, 524, 608, 621, 690, 723, 80,

89Col2a1 285, 83Collagen 27, 320, 40, 41, 466, 55, 65, 66, 784Collagen Fibrils 399Collagen Type II 133, 141, 304, 474, 67COMP 699Complications 331, 334Computational 269, 448, 493, 508Corticosteroid 275, 498, 737, 741Corticosteroid Injection 160, 498, 534, 652, 718,

720, 735, 745, 747, 749, 754Cost-Efficacy 650, 718COX-2 164, 764Crystal Arthritis 541Culture 566, 743, 794CXCL12 174Cyclic Mechanical Stimulation 132Cytokine 104, 153, 168, 169, 277, 287, 480, 71, 712,

796Cytoprotection 169Cytoskeleton 494Ddr2 626Degeneration 292, 305, 379, 427, 732Degradation 270, 571, 69Determinants 654Dexamhetasone 722Diagnosis of OA 12, 35, 447, 448, 452, 455, 456, 468,

472, 487, 538, 602Diagnostics 34, 569Differentiation 120, 132, 141, 152, 26, 760Digital 236, 241, 659, 692, I-5Disability 380, 394, 539, 561Disease Modification 295, 32, 37, 88Disease Progression 600

https://doi.org/10.1016/j.joca.2020.02.0261063-4584

Osteoarthritis and Cartilage 28 (2020) S544eS546

Disparity 237, 666DXA 590Dysplasia 52Early Knee OA 15, 157, 224, 425, 427, 434, 458, 514,

519, 569, 57, 577, 611, 696Education 252, 537, 547, 613, 648, 653, 658, 662,

664Efficacy 711Effusion 397, 428, 731EGF-Receptor 123Elbow 580Elderly 378, 380Electromyography 326, 353, 358, 360Electrophysiology 186, 187Epidemiology 181, 200, 209, 309, 378, 38, 380, 388,

436, 559, 59, 600, 601, 608, 609, 610, 611, 612,614, 621, 629, 636, 638, 643, 647, 685, 77, 80, 89,I-9

Epigenetic Suppression 123, 125, 493, 498, 503, 56Estrogen Replacement Therapy 307European 543Exercise 15, 18, 20, 21, 227, 232, 236, 237, 238, 240,

245, 250, 252, 490, 491, 537, 584, 630, 645, 652,653, 658, 659, 663, 664, 668, 674, 680, 686, 691,692, 700, 701, 705, 710, 745

Extracellular 260, 480, I-8Failure 439Females 696Fibronectin Fragment 43Fibrosis 772Finite Element 783Flow Cytometry 134, 148, 157, 303Foot 398, 402, 407, 518, 622, 647, 694Function 16, 235, 239, 417, 532, 550, 567, 620, 639,

93Functional Limitation 206, 38, 573, 586, 603, 631,

635, 675Gabapentin 203Gait 233, 239, 33, 340, 341, 342, 343, 346, 349, 351,

352, 353, 356, 370, 371, 454, 603, 61, 677, 9Gait Analysis 313, 336, 337, 338, 347, 354, 360, 361,

362, 363, 364, 365, 367, 368, 372, 373, 59, 60, 63Gait Patterns 344, 633Gender Difference 180, 244, 349, 470, 558, 615, 653Gene Expression 125, 173, 180, 262, 297, 328, 469,

486, 492, 495, 502, 507, 509, 55, 793, 87, I-10Gene Therapy 283, 549, 764, 770, 771, 785, 787Gene Transfer 785Generalized Estimating Equations 600Generalized OA 475Genes 129, 173, 225Genetic Background 465Genetics 181, 492, 495, 504, 508, 53, 54, 55, 600, 78,

8, I-10Glucosamine 304, 671Gonarthrosis 316, 646, 703Growth Factor 793, I-14, I-17Growth Plate 115, 85Guidelines 663, 664, I-16Guinea Pig 108, 295Hand OA 166, 195, 196, 220, 386, 396, 466, 475, 504,

506, 530, 557, 558, 567, 616, 620, 626, 627, 632,639, 650, 71, 716, 76, 79, I-16

HDAC 286Health Assessment Questionnaire 685Health Beliefs 539, 586Health Related Fitness 237, I-5Healthy 416, 65Heme Oxygenase-1 254Herbal Remedy 136High-Throughput Screens 729Hip 168, 17, 205, 208, 209, 21, 228, 232, 238, 241,

245, 248, 308, 34, 361, 390, 391, 403, 447, 538,559, 565, 573, 596, 602, 604, 609, 614, 615, 617,619, 649, 651, 653, 655, 656, 658, 665, 702, 749,79

Histology 146, 175, 258, 408, 451, 576, 720Horse 305, 500, 511, 743Human 500, I-10

Human Movements 348, I-15Hyaluronan 484Hyaluronic Acid 275, 300, 304, 477, 672, 684, 746,

750, 752, 777Hypertrophy 30, 397, 428, 789Hypoxia 23, 774IGF-1 79IL-1 138, 283, 501, 733, I-17IL-1 beta 149, 150, 306, 484, 5IL-6 109, 138, 157, 158, 484, 742, 753, 769, 94Imaging 134, 176, 308, 327, 383, 387, 392, 396, 400,

405, 406, 409, 410, 433, 435, 442, 443, 446, 452,455, 457, 458, 46, 49, 50, 657, 747, I-4

Impact Injury 282Implant 338In Vitro Dynamic Compressive Loading 256, 259,

264, 266In Vitro Explant Culture 144In Vivo 176, 305, 728, I-11Inducible Nitric Oxide Synthase (iNOS) 162, 170,

742Inflammation 113, 122, 145, 147, 148, 149, 150, 152,

153, 155, 158, 159, 161, 164, 165, 166, 167, 168,170, 171, 174, 185, 188, 192, 219, 226, 273, 295,30, 31, 314, 315, 389, 412, 479, 485, 493, 5, 504,70, 71, 716, 727, 73, 740, 742, 748, 759, 772, 782,87, 95, 97, 98, 99, I-1

Injection 342, 695, 718, 752, 758Instability 301, 411, 413, 584Integrin 263, 302, 43, 779Interleukin-1 31, 732Interleukin-1 beta 145Intra-Articular 158, 172, 712Intra-Articular Injection 185, 197, 217, 226, 283, 31,

444, 734, 735, 737, 741, 745, 747, 754, 768Joint 222, 225, 290, 3, 52, 648, 694, 732Joint Distraction 551, 570, 704, 708, 86Joint Distruction 324Joint Injection 223, 267Joint Instability 317, 319, 468, 705Joint Laxity 362, 374Joint Pain 189, 191, 195, 200, 221, 553Joint Replacement 12, 175, 235, 243, 461, 529, 561,

617Joint Space Narrowing 92Joint Space Width 336, 432, 592Kinematics 242, 346, 350, 365, 374, 680, 9Knee 150, 231, 232, 234, 243, 250, 256, 320, 340,

345, 349, 352, 357, 384, 404, 413, 414, 435, 457,48, 51, 531, 559, 563, 565, 607, 617, 619, 646,655, 661, 691, 693, 698, 748, 773, 79

Knee and TM Joints 324Knee Joint 121, 167, 278, 416, 440, 560, 592, 676, 97Knee Joint Varus Moment 359, 364, 371, 58, 60Knee OA 168, 212, 223, 229, 230, 240, 241, 245, 247,

251, 272, 287, 306, 309, 327, 345, 351, 355, 359,371, 383, 409, 410, 418, 429, 430, 433, 437, 443,448, 452, 454, 455, 471, 476, 481, 483, 50, 515,520, 526, 528, 53, 547, 548, 551, 562, 58, 584,589, 594, 608, 637, 642, 662, 667, 684, 690, 699,746, 750, 76, 796, 88, 90

Knee Osteoarthritis 108, 111, 12, 125, 126, 160, 17,182, 189, 194, 197, 201, 204, 207, 208, 21, 211,215, 217, 218, 226, 227, 228, 231, 233, 238, 239,244, 246, 249, 25, 274, 277, 278, 279, 28, 288,295, 299, 303, 309, 311, 32, 320, 326, 330, 333,335, 338, 339, 341, 346, 347, 35, 353, 356, 358,361, 363, 364, 365, 366, 367, 368, 370, 374, 389,393, 401, 408, 41, 411, 422, 430, 438, 441, 446,456, 459, 46, 465, 467, 473, 477, 478, 480, 490,493, 496, 501, 503, 508, 511, 513, 517, 521, 527,533, 535, 536, 539, 542, 544, 545, 546, 554, 555,556, 557, 561, 564, 566, 570, 573, 574, 576, 578,585, 587, 588, 59, 590, 595, 596, 60, 601, 603,606, 61, 610, 612, 618, 621, 623, 624, 628, 629,63, 631, 633, 634, 635, 638, 645, 649, 651, 652,66, 664, 665, 670, 673, 68, 682, 695, 698, 7, 701,707, 708, 710, 711, 712, 714, 717, 721, 722, 723,

735, 736, 737, 739, 741, 745, 754, 759, 766, 769,77, 779, 786, 82, 9, 95, 99, I-1, I-3

Knee Pain 179, 194, 197, 211, 213, 215, 217, 222,223, 229, 327, 345, 346, 348, 393, 394, 517, 533,536, 588, 59, 604, 606, 623, 645, 699, 701, 706,723, 77

Knee Radiograph 309, 366, 589, 682Knockout Mouse 10, 115, 7KOOS 332, 337, 418, 544, 546, 563, 724Labeling 512Load 340, 464, 680Loading 265, 347, 439, 440, 624Long-Term 20, 236, 47, 516Lubricin 257, 491Macrophage 145, 152, 154, 155, 156, 159, 169, 177,

280, 297, 765, 769, 94, 95Magnetic Resonance Imaging 12, 201, 333, 343, 384,

385, 386, 390, 391, 393, 395, 404, 407, 408, 411,413, 416, 417, 426, 435, 436, 449, 456, 47, 474,51, 521, 599, 607, 641, 724, 747, 88

MAP Kinase 139MAPK 170Markers 312, 8Mass Spectrometry 316, 438, 510, 514, I-8Matrix Invasion I-8Matrix Metalloprotease 113, 118, 273, 300Matrix Metalloproteinase 170, 468, I-14Matrix Synthesis 254, 272, 379, 726, 743, 794, 86Measurements 502, 562, 630Mechanical Loading 201, 264, 348, 350, 374, 728,

I-11Mechanical Properties 271, 783Mechanical Stimulation 256, 263, 783, 87Mechanical Stress 118, 266, 317, 319Mechanical Trauma 117, 259, 261, 282, 467Mechanotransduction 254, 300, 84, 85Medial Meniscal Tear 15, 187, 431Meniscal Tear 334, 395, 78Meniscectomy 15, 520Meniscus 224, 303, 329, 332, 399, 406, 422, 427,

430, 431, 432, 439, 51, 548, 599, I-3, I-6Mesenchymal Stem Cell 120, 130, 131, 14, 23, 27,

303, 755, 756, 757, 759, 760, 761, 765, 766, 767,769, 770, 771, 772, 777, 780, 784, 790, I-6

Meta-Analysis 326, 334, 382, 525, 540, 570Metabolic Obesity 125, 299Metabolism 219, 265, 29, 5, 6, 71Metalloproteases-13 715Metalloproteinase 784Micro-CT 253, 310, 399, 499Microarray 113Mitochondria 10, 117, 23, 261, 273, 282, 74MMP 255, 464, 482MMP-13 128, 140, 753MMP-2 468Morphology 322, 388, 450Morphometry 388MR Imaging 212, 213, 325, 330, 389, 396, 400, 401,

406, 415, 420, 427, 431, 432, 437, 439, 440, 441,519, 529, 564, 679, I-3, I-4

mRNA 503, 505Murine Model 142, 179, 190, 2, 23, 296, 4, 94, 96, 99Muscle 210, 279, 326, 329, 373, 420Muscle Activation 61, 63Muscle Stiffness 234Muscle Strength 210, 327, 522, 583, 635Muscles Contracture 356Musculoskeletal Disorders 115, 184, 221, 639, I-2Natural Product 671Neoepitope 259, 466Nitric Oxide 715Nitrite Oxide 172Non-Viral Gene Transfer 290Notch 178NSAIDs 160, 689, 725, 750, 81Nuclear Factor-kB 137, 496OA Animal Models 101, 11, 110, 155, 176, 183, 188,

191, 192, 281, 283, 284, 286, 288, 29, 293, 294,

Keyword Index / Osteoarthritis and Cartilage 28 (2020) S544eS546 S545

313, 318, 44, 499, 5, 507, 52, 56, 713, 73, 74, 763,95, I-1, I-11

OA Definitions 640Obesity 147, 188, 196, 227, 4, 470, 475, 478, 517,

521, 617, 620, 693, 76, 98, I-1OMERACT-OARSI Criteria 746, 90Opening Wedge High Tibial Osteotomy 366, 564Orthoic Devices 358, 372, 587, 694Osteoblasts 272, 782Osteochondral Defect 27, 791Osteoclast Survival 194Osteophyte 110, 151, 224, 302, 308, 393, 408, 409,

422, 425, 429, 430, 432, 436, 44, 551, 739Osteoporosis 640Osteotomy 371, 551, 58, 592, 698, 711, 90Outcome 21, 38, 383, 396, 46, 467, 518, 527, 531,

532, 545, 547, 558, 560, 586, 588, 593, 637, 654,661, 669, 678, 68, 681, 685, 80, 93, I-16

Oxycodone/Acetaminophen 198, 689p53 719Pain 16, 173, 175, 176, 177, 178, 179, 18, 180, 181,

182, 183, 184, 185, 187, 190, 192, 195, 196, 199,200, 201, 202, 204, 205, 206, 207, 208, 209, 210,212, 214, 216, 219, 220, 221, 222, 224, 247, 249,252, 278, 306, 324, 33, 344, 378, 380, 389, 39,392, 397, 431, 523, 529, 530, 531, 540, 552, 562,566, 567, 574, 583, 586, 593, 605, 620, 625, 631,639, 646, 647, 675, 681, 687, 693, 697, 706, 716,725, 730, 731, 740, 763, 782, 92, 96, I-18

Patellofemoral 234, 343, 373, 413, 421, 516, 519,550, 552, 572, 575, 587

Pathogenesis 162, 220, 287, 362, 412, 505, 7, I-12Patient Reported Outcomes 520, 540, 544, 552, 553,

572, 577, 585, 597, 598, 622, 675, 708, 746PCR 135Peak Adduction Moment 347, 354Phenotype 112, 166, 219, 384, 479, 533, 543, 553,

576, 6, 64, 640, I-13Physical Activity 19, 206, 230, 241, 243, 244, 250,

352, 353, 37, 418, 454, 521, 524, 537, 550, 559,575, 577, 579, 610, 630, 631, 641, 645, 66, 674,89, 93

Physical Examination 528Physical Function 215, 229, 524, 532, 574, 590, 610,

611, 628, 677, 681, 701Physiotherapy 19, 227, 231, 242, 243, 248, 532, 663,

667, 668, 669, 673, 686, 689, 696, 700, 703, 786Placebo Benefit 526Post-Traumatic 117, 156, 261, 329, 337, 350, 546,

729, 733, 734, 96, 99Pre-Chondrocytes 778Preclinics 727Predictors of Improvement 18, 239, 487Predictors of Progression 378, 459, 461, 489, 518,

528, 543, 622Prevalence 384, 602, 615, 623, 744Programming 377, 668Progression 344, 36, 406, 446, 457, 471, 584, 589,

598, 739, 752, I-18

Proliferation 116, 136, 291, 776, 794Promoter 460Protein 489, 510, 577Proteoglycan 732Proteoglycan Synthesis 86Proteomics 146, 40, 506, 512, 513, I-8Quadriceps 341Quadriceps Strength 550Quality of Life 18, 20, 205, 372, 523, 563, 575, 593,

611, 634, 640, 646, 685, 690, 702, 710, 735, 754Quantitative 195, 399, 649Quantitative Morphometry 445Quantitative MRI 335, 339, 412, 414, 415Quantitative Real Time PCR 10, 792Rabbit 451Race 632, 654Radiographic OA Grade 202, 328, 421, 447, 452, 455,

483, 517, 565, 572, 616, 627, 632, 67Radiographic Progression 459, 465, 597, 612, 622,

627Radiography 35, 388, 421, 448, 449, 457, 557, 591Rat 147, 444Real-Time PCR 193, 324Receptor 111, 174Registration 414, 450, 62, 682Rehabilitation 19, 228, 229, 230, 232, 235, 247, 248,

249, 251, 364, 525, 563, 585, 593, 604, 651, 659,669, 697, 703, 786, I-16, I-5

Reporter Assay 105, 460Responder 527, 598, 695, 697, 90Resveratrol 753Rheumatic Diseases 643Risk Factors 415, 555, 597, 605, 616, 626, 627, 628,

633, 726, 89Runx2 118S-100 775Safety 534, 549, 556, 81Scaffold 790Segmentation 451Self-Report 691Sensitivity to Change 426Sensor 242Serum 471, 485, 491Shear Stress 254, 265Shoulder 580Shoulder Joint 541, 660Shoulder Pain 660Signal Transduction 108, 135, 139, 154, 43, 502, 738Signaling 126, 225, 469, 476, 486, 714Smad 122SOX9 285Statistical Study 202, 449, 68, 688, 92Stem Cells 148, 154, 22, 24, 26, 376, 377, 443, 480,

756, 763, 773, 776, 780, 781, 791, 795Strengthening 573, 604, 674, 691Stress 186, 284Study Design 726Subchondral Bone 13, 272, 289, 3, 311, 458, 509

Surgery 20, 249, 313, 325, 334, 426, 655, 656, 660,663

Surgically Induced Osteoarthritis 13, 177, 186Symptoms 37, 518, 525, 535, 560Synovial Fibroblast 153, 189, 315, 316, 757, 96Synovial Fluid 112, 116, 117, 134, 145, 257, 287,

485, 513, 514, 515, 765, 97Synovial Inflammation 104, 146, 155, 157, 280, 325,

469, 486, 773Synoviocytes 191, 766Synovitis 13, 151, 179, 189, 199, 301, 318, 342, 412,

435, 442, 684, 748, 98Synovium 274, 275, 280, 281, 291, 297, 307, 318,

488, 494, 728, 777, 82, 87, I-18, I-6Systematic Review 251, 534, 570, 619, 624TGF-b1 301, 495, 549TGF-beta 119, 122, 481, 512, 792, I-14Therapy 140, 165, 171, 183, 185, 190, 203, 22, 31,

382, 64, 650, 662, 714, 716, 729, 744, 757, 97,I-17, I-7

Tibiofemoral 343, 365, 404, 411, 516Time-Course Evaluation 561Tissue Engineering 27, 377, 756, 758, 761, 767, 778TNF-alpha 149, 150, 158, 761, 790Topograhy 409Total Joint Replacement 17, 545, 582Total Knee Arthroplasty 216, 252, 510, 524, 545,

554, 574, 581, 61, 654, 661, 669, 672, 689, 709, 93Total Knee Replacement 17, 449, 582, 678, 92Transcription 508Transcription Factors 100, 755Transcriptional Regulation 100, 133, 25, 497Transdermal Drug Delivery 750Transforming Growth Factor (TGF)- beta 1 177, 788Transforming Growth Factor beta 109, 795Transgenic 143, 501, 713Treatment 173, 220, 226, 236, 245, 290, 382, 568,

651, 670, 708, 721, 75, I-5Treatment Response 270, 299, 354, 363, 487, 690,

719, 723Type II Collagen 268Ultrasonography 684Ultrasound 397, 403, 424, 428, 748Ultrasound Guided Injection 444, 718Validation 588Validity 204, 251, 403, 677Varus 440Varus Deformity 366, 368, 372, 682Viability 144Viscosuplementation 672Viscosupplement 257Volume 599Weather Conditions 594WOMAC 208, 363, 478, 526, 531, 536, 594, 636, 719,

722, 724, 725, 796WORMS 36, 415, 422, 594, 641, 724Wound 1, 381X-ray 160, 398, 402, 410, 416, 421, 433, 555, 607,

629, 638, 644, 721

Keyword Index / Osteoarthritis and Cartilage 28 (2020) S544eS546S546