new requirements for high tech core facilities: shared ... · chirag mistry, aia senior laboratory...
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New requirements for high tech core facilities: Shared resources, space, technology, capital costsThe HOK Science + Technology Group l JE Dunn Construction l 21 October 2013Presenters: Randy Kray l Chirag Mistry l Kevin Brettmann
PRESENTERS
Randy Kray, AIAHOKDirector, Science & [email protected]
Chirag Mistry, AIAHOKSenior Laboratory Planner [email protected]
Kevin BrettmannJE Dunn ConstructionDirector, Science & [email protected]
Takeaway Objectivescore facility science and business drivers I trends and issues
infrastructure requirements l flexibility & adaptability
Core Facility Definition
A core facility is defined
as a centralized, shared
resource that provides
access to instruments
or technologies or
services, as well as
expert consultation to
investigators supported
by the core.
Inter-Disciplinary Research
Catalysts– Genomics &
Proteomics– Advanced Imaging– Nanoscale Science– Computational
Modeling – Bioengineering– Regenerative
Medicine
Convergence
BiophysicsMolecular Engineering
Transformative
Medical• Translational• Regenerative• Genomic
Materials• Synthesis• Polymer• Membranes
Engineering• Nanofabrication• Molecular• Tissue
Next…
Core Facilities
Small AnimalLarge Animal
DiscoveryEfficacy/GLP
Pathogen Free
Vivarium
MRI/PETProton/Cyclotron
CT/X-RayUltrasonic
Spectrometry
Diagnostics
Tissue banksTissue culture
Reference samplesCell Pathology
Toxicology
Specialty Lab: Pathology, Histology
Core Facilities
ResearchDevelopmentFormulation
Biochem/Small MoleculeBiologics/Large Molecule
cGMP/Pilot Scale
GMP Production
Top Down DevicesBottom Up Materials
DepositionTissue Engineering
Bioengineering
Nanofabrication Cleanrooms
SEM/TEM/STEMMRI/NMR
X-Ray CrystallographyOptical/LaserAFM/Probe
Imaging
Core Service Typology
• Resource Driven– In-vivo/Transgenic– GMP/Fabrication
• Data Driven– Bioinformatics– Genomics
• Equipment Driven– Cellular Imaging– Nuclear Imaging– Diagnostics
Cost Benchmarking
$‐ $100 $200 $300 $400 $500 $600 $700 $800 $900
Animal Facility
Informatics
cGMP Facility (1000)
Biocontainment
Nanofabrication
Biomedical Research
Low Range
High Range
Lab Design News, 2013 Lab Construction Outlook
Funding & Cost Recovery
• “Cup-in-Hand” funding
• Strictly service cost recovery; capital/equipment cost not recoverable.
• Can make limited profit from external clients
• Equipment depreciation does not keep up with technology
ROI:
Critical to attract facultyCritical to compete for grants
Contribute F&A indirects from increasing grant revenue
CORE FACILITY DRIVERS
Key Issues
• Changing Technology– Where is the science going– Capital & equipment investment
options
• Management – Maintaining efficiency and quality– Maintaining regulatory compliance– Cost-tracking and cost recovery
• Research Integration– How does core expertise
support/integrate into research teams
– How do you develop collaborative partnerships
Trend: Consolidation
• Consolidation of cores to support different multiple funding sources– Higher utilization and less duplication– Physical or operational consolidation
• Cost of relocation• Need for proximity to research (i.e. cellular imaging)
– Optimize resources, training and technologies
Trend: Partnering & Collaboration
• Institutions specializing in core competence.
• Cryopreservation – allowing transgenic research
with other institutions without quarantine delays
– Increased need for LN2 freezer storage
Trend: Research Integration
• Existing locations often prohibit collaboration
• Core/Center strategy– Inside Center there is a component that
produces a service, e.g. Proteomics
– More complex to budget and manage cost recovery
• Service center software used for improving billing and productivity– Equipment based cores easiest to
incorporate software tool
• Some cores technologies have become a commodity and less likely to need collaboration– Flow Cytometry
Lab neighborhoods lining a central atrium
Trend: Research Colocation
Trend: Research Integration –Core Management• Technical Director
– Leads the production line– 100% dedicated – Reports to Scientific Director
• Scientific Director – Highly productive Sr. Researcher with specialty in the
service– 10-20% core payroll– External face of the core– Understands how the mouse gets built and where science
is going– Collaborates with PI/team to design project – hand over to
Tech Director
DESIGN TRENDS
Lab/Core Type Benchmarking
0%
10%
20%
30%
40%
50%
60%
70%
80%
90%
100%
FrancisCrick
Institute
UF InstituteFor
TherapeuticInnovation
USC CMSE VGTIFlorida
UT CedarsSinai
AdvancedHealthSciencesPavilion
WisconsinInstitutesfor MedicalResearch(WIMR )
Cleanroom/ Nano
GMP
Imaging
Diagnostics
Animal Core
Core Lab
Informatics
Research Office
Lab Support
Lab
Core/Non-Core
Data Driven Cores
• Genomics, Bioinformatics
• Utilizing both cloud storage and local storage
• Centralized servers with IT
• Integrated within research floors as a place of collaboration
• Sequencing is becoming a commodity – core value is in large data analysis
Lab neighborhoods lining a central atrium
Vaccine and Gene Therapy Institute
Service Driven Cores
Animal Facility Trends:• Species shift
– Increase in rats – behavioral & neuroscience– Increase in pigs and sheep – biomedical device
• Embryonic cryogenics– Reducing barrier to collaboration internally and externally– Increased need for freezer storage
• Chronic and acute procedures• Whole animal imaging technology• Centralized cagewash and disposable solutions
Case Study - Wisconsin Institutes for Medical Research (WIMR )
Imaging core serving clinical and in-vivo research
Equipment Driven Cores - Advanced Imaging Cores• Modalities
– Electron Microscopy– Crystallography – Functional imaging– High end optical and laser– Tool development
• Challenges– Low-vibration environment– Low EMI environment
• Key Questions– What tools do I need?– What is my site allowing me to
do?
Equipment Driven Cores - Nanofabrication
• Applications– Drug delivery– Biosensing– Bio MEMS– Device development
• Challenges– Hazardous processes – Low-vibration – Infrastructure– Safety issues
• Key Questions– Do I develop nanoscale
science?– What tools are needed ?
University of Southern California CMSE
NANO
IMAGING
SPECIAL LAB
THE BASEMENT IS THE NEW BEACHFRONT
INFRASTRUCTURE REQUIREMENTS
Infrastructure Requirements
• Building Structure• Floor to Floor height• Vibration
• Building Services• Ventilation• Special Gases/Water• Electrical Backup
• Isolation/Shielding• EMI• RF
• Daylight & Views• Natural Light• Light Exclusion
• Building Flow• Service Access
• Safety & Security• High Security• High Hazard• Disaster Plan
Infrastructure RequirementsSTRUCTURE
FLOO
RTO
FLO
OR H
EIGH
T
VIBR
ATIO
N
BIOINFORMATICS
CELL CULTURE
PATHOLOGY
VIVARIUM
DIAGNOSTICS
IMAGING
CLEAN ROOM /GMP
CLEAN ROOM / NANO
UNDESIREABLE
NEUTRAL
DESIREDBuilding Structure
SERVICES
INCR
EASE
D VE
NTILA
TION
SPEC
IAL G
ASES
\WAT
ER
ELEC
TRIC
AL B
ACKU
P
BIOINFORMATICS
CELL CULTURE
PATHOLOGY
VIVARIUM
DIAGNOSTICS
IMAGING
CLEAN ROOM /GMP
CLEAN ROOM / NANO
Infrastructure RequirementsBuilding Services
UNDESIREABLE
NEUTRAL
DESIRED
ISOLATION
EMI
RF
BIOINFORMATICS
CELL CULTURE
PATHOLOGY
VIVARIUM
DIAGNOSTICS
IMAGING
CLEAN ROOM /GMP
CLEAN ROOM / NANO
UNDESIREABLE
NEUTRAL
DESIREDInfrastructure RequirementsIsolation/Shielding
Infrastructure RequirementsLIGHT
NATU
RALL
IGHT
AND
VIE
W
LIGHT
EXC
LUSI
ON
BIOINFORMATICS
CELL CULTURE
PATHOLOGY
VIVARIUM
DIAGNOSTICS
IMAGING
CLEAN ROOM /GMP
CLEAN ROOM / NANO
UNDESIREABLE
NEUTRAL
DESIREDDaylight & Views
Infrastructure Requirements
SERV
ICE
ACCE
SSBIOINFORMATICS
CELL CULTURE
PATHOLOGY
VIVARIUM
DIAGNOSTICS
IMAGING
CLEAN ROOM /GMP
CLEAN ROOM / NANO
UNDESIREABLE
NEUTRAL
DESIREDAccess
Infrastructure RequirementsSECURITY
HIGH
SEC
URIT
Y
HIGH
HAZ
ARD
DISA
STER
PLA
N
BIOINFORMATICS
CELL CULTURE
PATHOLOGY
VIVARIUM
DIAGNOSTICS
IMAGING
CLEAN ROOM /GMP
CLEAN ROOM / NANO
UNDESIREABLE
NEUTRAL
DESIREDSafety & Security
Infrastructure RequirementsSTRUCTURE SERVICES ISOLATION LIGHT SECURITY
FLOO
RTO
FLO
OR H
EIGH
T
VIBR
ATIO
N
INCR
EASE
D VE
NTILA
TION
SPEC
IAL G
ASES
\WAT
ER
ELEC
TRIC
AL B
ACKU
P
EMI
RF NATU
RALL
IGHT
AND
VIE
W
LIGHT
EXC
LUSI
ON
SERV
ICE
ACCE
SS
HIGH
SEC
URIT
Y
HIGH
HAZ
ARD
DISA
STER
PLA
N
BIOINFORMATICS
CELL CULTURE
PATHOLOGY
VIVARIUM
DIAGNOSTICS
IMAGING
CLEAN ROOM /GMP
CLEAN ROOM / NANO
UNDESIREABLE
NEUTRAL
DESIRED
AN ADAPTABLE CORE PLATFORM
Core Space Flexibility – The Future Toolset
• The Challenge– Can core space be strategically planned independent
of the current tool or technology?• Address the evolving and rapidly changing technologies• Increasing demand for vibration sensitivity, power, data, etc.• Growth of chemical engineering and physics tools in
research
• The Strategy– Develop a universal core & shell strategy independent
of the research tools.
Core Space Construction Cost Trends
Building Core + Shell TI Fitout Total
Structure 11%-15% 0% 11-15%
HVAC & Controls 7-9% 8-9% 15-18%
Electrical & Security 3-5% 5-6% 9-11%
Plumbing/Fire Prot. 2-3% 3-6% 6-9%
Architecture 12-15% 20-25% 36-40%
AdaptabilityStrategy
FlexibilityStrategy
Construction Cost by Trade
0
200
400
600
800
1000
1200
ResearchLab
Vivarium Imaging Cleanroom Nano
TISpecialArchitecturePlumbingElectricalHVACStructureFoundation
Core & Shell Costs
0
50
100
150
200
250
300
350
400
450
500
ResearchLab
Vivarium Imaging Cleanroom Nano
SpecialArchitecturePlumbingElectricalHVACStructureFoundation
Core & Shell Adaptability Strategies
Option 1: Research Lab, Vivarium, Imaging, Cleanroom, NanoOption 2: Research Lab, Vivarium, Imaging, Cleanroom Option 3: Research Lab, Imaging, Vivarium (no interstitial)
0
50
100
150
200
250
300
350
400
450
500
Special
Architecture
Plumbing
Electrical
HVAC
Structure
Foundation
Data Options
Lower Level 1
Cleanroom
[VC-E, Epoxy Coated Rebar]
[VC-D]
High Performance Labs
[VC-D]
Example: William Eckhardt Research Center
• Decision making:– Core strategy needs commitment at program/ concept– TI is where there is cost flexibility - adhere to C&S strategy
Tradeline Three
• Consolidation and partnering reduces cost and maximizes your revenue
• Integrating cores physically and scientifically within your programs creates synergy and innovation
• Adaptable core space through C&S strategies provides capability for new toolsets. Needs full buy-in early in design process.
DISCUSSION