Primary plastic packaging for the pharmaceutical industry

We offer: • A standard range of pharmaceutical

snap-on bottles for spray pumps, eye-droppers, container bottles, caps, cups and spoons;

• Development and manufacture of tailor-made pharmaceutical plastic packaging solutions and Class I medical devices.

PlasticProgress Pharma Packaging is specialized in the manufacture of primary plastic packaging and Class I medical devices for the pharmaceutical industry.

We provide full traceability throughout the manufacturing process, from the raw materials used up to the delivery of our products. Detailed drawings and specifications of the standard range of products we manufacture are available upon request.

We run an efficient manufacturing operation, with an up-to-date production lay-out, optimized procedures and state-of-the-art injection-blow moulding and injection moulding machines.

We are certified to ISO 9001:2008 since October 2011, and to ISO 15378:2011 standards since April 2013.

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The manufacture, assembly and packaging takes place in our cleanroom facilities, applying the rules of Good Manufacturing Practices (GMP).

Our cleanroom is regularly audited and qualified to ISO Class 7, with a constant ISO Class 5 laminar flow in the moulding area, in full compliance with ISO 14644-1 standards. Our offer of standard and customized products meet your highest demands in safety, accuracy and functionality.

We are flexible in order to help you to deliver results - as your supplier, we are a reliable partner that ensures supply of your primary plastic packaging needs.

Our offer meets your highest demands in quality and safety: • Focus in customer service; • High functional quality products; • Flexibility and capacity to adapt; • Know-how and experience; • Fulfilment of our engagements.

• 12ml, 20ml and 30ml snap-on bottles with S20 neck finish for spray pumps for nasal, ophthalmic, ear, buccal, throat or topical applications;

• 5ml, 10ml and 15ml dropper bottles with tamper-evident caps;

• 5ml spoons and 10ml, 20ml and 25 ml cups;

• 100ml and 150ml bottle containers for capsules and tablets with 38mm screw-on caps or snap-lock caps;

• 35ml bottle containers for moisture-sensitive solid formulations with desiccant capsules embedded in our 36mm tamper-evident caps.

Snap-On Bottles

• Rigid bottles produced in HDPE with injection-blow moulding technology for superior dimensional accuracy and quality;

• Produced in our qualified ISO Class 7 cleanroom, with ISO Class 5 laminar flow in the moulding area, in compliance with ISO 14644-1 standards;

• S20 neck finish qualified for use with Aero Pump and West Rock spray pump devices.

• Available range: 12ml, 20ml and 30ml bottles;

• 15ml bottle with Aptar F-1301 neck finish under development;

• Sealed and packed under validated packaging process according to ISO 11607-2 standards.

• Squeezable bottles produced in LDPE with injection-blow moulding technology for superior dimensional accuracy and quality;

• Cap with tamper-evident ring; • Produced and sealed in our qualified ISO Class 7 cleanroom, with ISO Class 5

laminar flow in the moulding area, in compliance with ISO 14644-1 standards.

• Available range: 5ml, 10ml, and 15ml bottles;

• 30ml bottles under development; • Sealed and packed under validated

packaging process according to ISO 11607-2 standards.

Dropper Bottles

Tablet & Capsule Containers

• Container bottles for solid oral formulations, produced in HDPE with injection-blow moulding technology for superior dimensional accuracy and quality;

• Screw-on and snap-lock caps with tear-off seal strip available according to your requirements;

• Bottles and caps manufactured in our ISO Class 7 cleanroom, with ISO Class 5 laminar flow in the moulding area, in compliance with ISO 14644-1 standards.

• Available range: 100ml and 150ml; • 200ml and 250ml bottles under

development; • CRC closures available; • Automatic assembly of foam liners,

induction heat seals and pressure-sensitive seals according to your needs.

• Container bottles for moisture-sensitive solid or granulate oral formulations, produced in HDPE with injection-blow moulding technology for superior dimensional accuracy and quality;

• Cap with tamper-evident ring, with embedded desiccant canisters; • Bottles and caps manufactured in our ISO Class 7 cleanroom, with ISO Class 5

laminar flow in the moulding area, in compliance with ISO 14644-1 standards.

• Available in 35ml capacity; • 20ml and 50ml capacities under

development; • Automatic embedding of Sanner or

Clariant desiccant canisters in the caps according to your requirements.

Moisture-Barrier Bottle Containers

Class I Medical Devices - Cups and Spoons

• 10ml, 20ml and 25 ml cups produced in food-grade PP polymer; • 5ml spoons available in food-grade PP or PS polymers; • Cups and spoons may be manufactured in our ISO Class 7 cleanroom to ISO

14644-1 standards upon requirement.

• Standard packaging in bulk, in double brace-sealed bags;

• Special packaging and bag sealing available according to your requirements.

Class I Medical Devices - Cups and Spoons with Measuring Function

• We have in place all the procedures to implement full compliance to Directive 93/42/EEC, Annex V, to apply the CE mark on your Class I Medical Devices; our certification is currently on hold.

• 5ml spoons and 25ml cups available with CE (0120) marking, once current certification is renewed;

• Produced and sealed in our ISO Class 7 cleanroom compliant to ISO 14644-1 standards, with ISO Class 5 laminar flow in the moulding area.

Development and Manufacturing Services

• We support the development and manufacture of bespoke primary plastic packaging solutions and Class I Medical Devices, from small pre-series manufacture up to high production volumes;

• Support is provided in product engineering, 3D prototype printing, and tooling manufacturing.

• Parts assembly performed according to your requirements;

• Manufacture, sealing and packaging in ISO Class 7 cleanroom compliant to ISO 14644-1 standards, with ISO Class 5 laminar flow in the moulding area.

Our modern injection-blow moulding machines allow us the manufacturing of plastic bottles, containers and vials from 5,0 ml up to 500 ml.

• State-of-the-art machinery;

• High capacity output and short injection cycles;

• Superior quality and dimensional accuracy of the snap-on bottles for spray-pumps, eye-droppers, container bottles and vials.

We use injection moulding for the manufacture of caps and closures, Class I medical devices such as cups and spoons, or any other plastic components, parts or devices, from 1,0 g up to 2,0 kg.

• State-of-the-art machinery;

• Multiple capacity machines allowing for high production flexibility;

• Proven technology providing a reliable output.

Our injection machines, with state-of-the-art hybrid technology, are isolated under positive clean-air pressure and HEPA filters, feeding the packaging area inside the cleanroom.

A laminar flow of ISO Class 5 is permanently kept over the moulding area, in full compliance to ISO 14644-1 standards.

The production area is located outside our ISO Class 7 cleanroom, for added production efficiency and increased safety of your products.

All of our products for the pharmaceutical industry are sealed and packed without human contact in our ISO Class 7 cleanroom, in full compliance with ISO 14644-1 standards.

A validated packaging process according to ISO 11607-2 standards is available for products to be sterilized.

Our clean room facilities are under permanent surveillance for temperature, pressure and humidity control, ensuring our high quality standards.

An assembly machine is available for the automatic in-line application of foam liners, induction-heat seals and pressure-sensitive seals, as well as for embedding desiccant capsules in our range of caps.

- Use foam liners, induction-heat seals or pressure-sensitive seals for added tamper protection to your packaging;

- Use embedded desiccant capsules in the caps to protect your moisture-sensitive solid or granulate oral formulation product.

Statistical batch-control and online checking of our products during the production process is accomplished using the most recent technologies.

Several parameters are continuously checked during production, such as:

• Vision measuring;

• Weight control;

• Leakage testing.

The polymers used in the manufacture of our products are chosen upon strict quality criteria, and are in full compliance with the European Pharmacopeia. We are also available to manufacture according to your own local requirements.

Only virgin polymers are used, from world-renowned manufacturers and according to customer and product requirements:

• PE (Polyethylene);

• PP (Polypropylene);

• PS (Polystyrene).

Extensive warehousing facilities allow us to offer our partners a seamless supply, with short lead times for new products and delivery from stock of our standard range of pharmaceutical products.

With our flexibility, short reaction times, competitive prices and capacity to adapt to your market demands, we can readily integrate your supply chain and reply to your current challenges.

You can capitalize on your market opportunities ensuring supply security.

John Redin Sales Director Mobile: + 351 938 282 660 e-mail: john.redin@plasticprogress.com

Progressoplaste, Lda Estrada de Polima, 729 – Abóboda 2785-543 São Domingos de Rana Portugal Tel. + 351 214 454 289 Fax +351 214 452 448 www.plasticprogress.com GPS: 38º43'29"N 9º19'40"W

Contact us now!