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is published twice each month byThe Journal of Immunology

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VOL. 196 | NO. 9 | May 1, 2016 | Pages 3497–3972

IN THIS ISSUE3497 Protease Inhibitors Perturb Peptide Presentation See article p. 3595

Treg Transitions Impact Tolerance See article p. 3665Interrogating HIV Vaccine B Cell Responses See article p. 3729Fish Virus Is Unfriendly to IFN See article p. 3744Making Memories without IL-15 See article p. 3920

TRANSLATING IMMUNOLOGY3499 The Opportunity To Eradicate Peste des Petits Ruminants

Jeffrey C. Mariner, Bryony A. Jones, Karl M. Rich, Samuel Thevasagayam, John Anderson, Martyn Jeggo, Yi Cai,

Andrew R. Peters, and Peter L. Roeder

PILLARS OF IMMUNOLOGY3507 Discovery of the gd TCR: Act II

Willi K. Born and Rebecca L. O’Brien

3509 Pillars Article: Identification of a Putative Second T-Cell Receptor. Nature. 1986. 322: 145–149Michael B. Brenner, Joanne McLean, Deno P. Dialynas, Jack L. Strominger, John A. Smith, Frances L. Owen,

J. G. Seidman, Stephen Ip, Fred Rosen, and Michael S. Krangel

3514 Pillars Article: A Functional T3 Molecule Associated with a Novel Heterodimer on the Surface ofImmature Human Thymocytes. Nature. 1986. 322: 179–181Ilan Bank, Ronald A. DePinho, Michael B. Brenner, Judy Cassimeris, Frederick W. Alt, and Leonard Chess

BRIEF REVIEWS3517 Assembly and Expression of Shark Ig Genes

Ellen Hsu

On the cover: Using multiplex fluorescent microscopy to examine the distribution of T cell subsets in an untreatedSCCVII transplantable tumor (CD3 [red], CD8 [yellow], Foxp3 [green], Ki67 [orange], DAPI [blue]). Feng, Z., S. M. Jensen,D. J. Messenheimer, M. Farhad, M. Neuberger, C. B. Bifulco, and B. A. Fox. 2016. Multispectral imaging of T and B cells

in murine spleen and tumor. J. Immunol. 196: 3943–3950.

The Journal of Immunology (ISSN 0022-1767) is published twice each month by The American Association of Immunologists,Inc., 1451 Rockville Pike, Suite 650, Rockville, MD 20852, Phone: 301-634-7197, Fax: 301-634-7829. Subscription terms:New subscriptions and renewals begin January 1 and expire one year later (see http://www.jimmunol.org/subscriptions for prices

and details). A special rate is available to members of The American Association of Immunologists, Inc. (see http://www.aai.org/membership). The American Association of Immunologists, Inc., is not responsible for undeliverable issues. Replacement issuescan be obtained, if available, at the regular price of single issues (see http://www.jimmunol.org/pdf/single_issue_purchase.pdf).Reprints of individual articles are available only from authors. Periodicals postage paid at Rockville, MD 20852, and at additional

mailing offices. Country of origin U.S.A. Printed on acid-free recyclable paper. Postmaster: Send address changes 60 days inadvance to The Journal of Immunology, Subscription Department, 1451 Rockville Pike, Suite 650, Rockville, MD 20852.Copyright � 2016 by The American Association of Immunologists, Inc.

Journal ofTh e

ImmunologyTable of Contents

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CUTTING EDGE3525 Cutting Edge: BAFF Promotes Autoantibody Production via TACI-Dependent Activation of Transitional

B CellsHolly M. Jacobs, Christopher D. Thouvenel, Sarah Leach, Tanvi Arkatkar, Genita Metzler, Nicole E. Scharping,

Nikita S. Kolhatkar, David J. Rawlings, and Shaun W. Jackson

3532 Cutting Edge: Innate Lymphoid Cells Suppress Homeostatic T Cell Expansion in Neonatal MiceUte Bank, Katrin Deiser, Daniela Finke, Gunter J. Hammerling, Bernd Arnold, and Thomas Schuler

3537 Cutting Edge: Foxp1 Controls Naive CD8+ T Cell Quiescence by Simultaneously Repressing Key Pathwaysin Cellular Metabolism and Cell Cycle ProgressionHairong Wei, Jianlin Geng, Bi Shi, Zhenghui Liu, Yin-Hu Wang, Anna C. Stevens, Stephanie L. Sprout, Min Yao,

Haikun Wang, and Hui Hu

3542 Cutting Edge: Integrin a4 Is Required for Regulatory B Cell Control of Experimental AutoimmuneEncephalomyelitisSimon Glatigny, Catriona A. Wagner, and Estelle Bettelli

ALLERGY AND OTHER HYPERSENSITIVITIES3547 TNF-a and Macrophages Are Critical for Respiratory Syncytial Virus–Induced Exacerbations in a Mouse

Model of Allergic Airways DiseaseThi Hiep Nguyen, Steven Maltby, Jodie L. Simpson, Fiona Eyers, Katherine J. Baines, Peter G. Gibson, Paul S. Foster,

and Ming Yang

3559 Subcutaneous Allergic Sensitization to Protease Allergen Is Dependent onMast Cells but Not IL-33: DistinctMechanisms between Subcutaneous and Intranasal RoutesSeiji Kamijo, Mayu Suzuki, Mutsuko Hara, Sakiko Shimura, Hirono Ochi, Natsuko Maruyama, Akira Matsuda,

Hirohisa Saito, Susumu Nakae, Hajime Suto, Saori Ichikawa, Shigaku Ikeda, Hideoki Ogawa, Ko Okumura,

and Toshiro Takai

3570 TIGIT Enhances Antigen-Specific Th2 Recall Responses and Allergic DiseaseEvangelia Kourepini, Nikolaos Paschalidis, Davina C. M. Simoes, Maria Aggelakopoulou, Jane L. Grogan,

and Vily Panoutsakopoulou

ANTIGEN RECOGNITION AND RESPONSES3581 CD83 Modulates B Cell Activation and Germinal Center Responses

Lena Krzyzak, Christine Seitz, Anne Urbat, Stefan Hutzler, Christian Ostalecki, Joachim Glasner, Andreas Hiergeist,

Andr�e Gessner, Thomas H. Winkler, Alexander Steinkasserer, and Lars Nitschke

3595 HIV Protease Inhibitor–Induced Cathepsin Modulation Alters Antigen Processing and Cross-PresentationGeorgio Kourjian, Marijana Rucevic, Matthew J. Berberich, Jens Dinter, Daniel Wambua, Julie Boucau, and Sylvie Le Gall

3608 Defining Viral Defective Ribosomal Products: Standard and Alternative Translation Initiation EventsGenerate a Common Peptide from Influenza A Virus M2 and M1 mRNAsNing Yang, James S. Gibbs, Heather D. Hickman, Glennys V. Reynoso, Arun K. Ghosh, Jack R. Bennink,

and Jonathan W. Yewdell

CLINICAL AND HUMAN IMMUNOLOGY3618 Restricting Glutamine or Glutamine-Dependent Purine and Pyrimidine Syntheses Promotes Human TCells

with High FOXP3 Expression and Regulatory PropertiesBarbara Metzler, Patrick Gfeller, and Elisabeth Guinet

IMMUNE REGULATION3631 TGF-b–Induced Regulatory T Cells Directly Suppress B Cell Responses through a Noncytotoxic

MechanismAnping Xu, Ya Liu, Weiqian Chen, Julie Wang, Youqiu Xue, Feng Huang, Liming Rong, Jin Lin, Dahai Liu, Mei Yan,

Quan-Zhen Li, Bin Li, Jianxun Song, Nancy Olsen, and Song Guo Zheng

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3642 Effector gd T Cell Differentiation Relies on Master but Not Auxiliary Th Cell Transcription FactorsJoana Barros-Martins, Nina Schmolka, Diana Fontinha, Marta Pires de Miranda, J. Pedro Simas, Ingrid Brok,

Cristina Ferreira, Marc Veldhoen, Bruno Silva-Santos, and Karine Serre

3653 Transient Surface CCR5 Expression by Naive CD8+ T Cells within Inflamed Lymph NodesIs Dependent on High Endothelial Venule Interaction and Augments Th Cell–DependentMemory ResponseDavid Askew, Charles A. Su, Deborah S. Barkauskas, R. Dixon Dorand, Jay Myers, Rachel Liou, Joseph Nthale,

and Alex Y. Huang

3665 Developmental Progression and Interrelationship of Central and Effector RegulatoryT Cell SubsetsKevin H. Toomer, Xiaomei Yuan, Jing Yang, Michael J. Dee, Aixin Yu, and Thomas R. Malek

3677 Pneumococcal Surface Protein A Plays a Major Role in Streptococcus pneumoniae–InducedImmunosuppressionSaumyaa, Lindsey Pujanauski, Jesus Colino, Michael Flora, Raul M. Torres, Elaine Tuomanen,

and Clifford M. Snapper

3686 Signal Inhibitory Receptor on Leukocytes-1 Limits the Formation of Neutrophil Extracellular Traps,but Preserves Intracellular Bacterial KillingKristof Van Avondt, Maarten van der Linden, Paul H. Naccache, David A. Egan, and Linde Meyaard

3695 TLR-Mediated Innate Production of IFN-g by CD8+ T Cells Is Independent of GlycolysisFiamma Salerno, Aurelie Guislain, Dilay Cansever, and Monika C. Wolkers

3706 Lipopolysaccharide-Induced Chorioamnionitis Promotes IL-1–Dependent Inflammatory FOXP3+ CD4+

T Cells in the Fetal Rhesus MacaqueCesar M. Rueda, Pietro Presicce, Courtney M. Jackson, Lisa A. Miller, Suhas G. Kallapur, Alan H. Jobe,

and Claire A. Chougnet

IMMUNE SYSTEM DEVELOPMENT3716 Functional Langerinhigh-Expressing Langerhans-like Cells Can Arise from CD14highCD162 Human Blood

Monocytes in Serum-Free ConditionGa€elle Picarda, Coraline Ch�eneau, Jean-Marc Humbert, Ga€elle B�eriou, Paul Pilet, J�erome Martin, Franck Duteille,

Pierre Perrot, Fr�ed�erique Bellier-Waast, Mich�ele Heslan, Fabienne Haspot, Fabien Guillon, Regis Josien,

and Franck Albert Halary

IMMUNOTHERAPY AND VACCINES3729 High-Resolution Longitudinal Study of HIV-1 Env Vaccine–Elicited B Cell Responses to the Virus Primary

Receptor Binding Site Reveals Affinity Maturation and Clonal PersistenceYimeng Wang, Christopher Sundling, Richard Wilson, Sijy O’Dell, Yajing Chen, Kaifan Dai, Ganesh E. Phad, Jiang Zhu,

Yongli Xiao, John R. Mascola, Gunilla B. Karlsson Hedestam, Richard T. Wyatt, and Yuxing Li

INFECTIOUS DISEASE AND HOST RESPONSE3744 Spring Viremia of Carp Virus N Protein Suppresses Fish IFNw1 Production by Targeting the

Mitochondrial Antiviral Signaling ProteinLong-Feng Lu, Shun Li, Xiao-Bing Lu, Scott E. LaPatra, Nu Zhang, Xu-Jie Zhang, Dan-Dan Chen, Pin Nie,

and Yong-An Zhang

3754 Bacterial DNA Protects Monocytic Cells against HIV-Vpr–Induced Mitochondrial MembraneDepolarizationMansi Saxena, Aurelia Busca, Martin Holcik, and Ashok Kumar

3768 Maternal Antibiotic Treatment Impacts Development of the Neonatal Intestinal Microbiomeand Antiviral ImmunityGabriela Gonzalez-Perez, Allison L. Hicks, Tessa M. Tekieli, Caleb M. Radens, Brent L. Williams,

and Esi S. N. Lamous�e-Smith

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3780 Identification of Immune Effectors Essential to the Control of Primary and Secondary Intranasal Infectionwith Brucella melitensis in MiceDelphine Hanot Mambres, Arnaud Machelart, Georges Potemberg, Carl De Trez, Bernhard Ryffel, Jean-Jacques Letesson,

and Eric Muraille

3794 Glial Cell–Elicited Activation of Brain Microvasculature in Response to Brucella abortus Infection RequiresASC Inflammasome–Dependent IL-1b ProductionM. Cruz Miraglia, Miriam M. Costa Franco, Ana M. Rodriguez, Paula M. Q. Bellozi, Carina C. Ferrari, Maria I. Farias,

Vida A. Dennis, Paula Barrionuevo, Antonio C. P. de Oliveira, Fernando Pitossi, Kwang Sik Kim, M. Victoria Delpino,

Sergio Costa Oliveira, and Guillermo H. Giambartolomei

3806 HIV-1–Mediated BAFF Secretion in Macrophages Does Not Require Endosomal TLRs, Type-I IFN, andNef, but Depends on the Cellular Phenotype StatusAlejandro M. Gomez, Michel Ouellet, Alexandre Deshiere, Yann Breton, and Michel J. Tremblay

3818 Relationship of NKG2C Copy Number with the Distribution of Distinct Cytomegalovirus-InducedAdaptive NK Cell SubsetsAura Muntasell, Aldi Pupuleku, Elisa Cisneros, Andrea Vera, Manuela Moraru, Carlos Vilches, and Miguel L�opez-Botet

INNATE IMMUNITY AND INFLAMMATION3828 Gai2 and Gai3 Differentially Regulate Arrest from Flow and Chemotaxis in Mouse Neutrophils

Yoshihiro Kuwano, Micha Adler, Hong Zhang, Alex Groisman, and Klaus Ley

3834 TLR10 Is a Negative Regulator of Both MyD88-Dependent and -Independent TLR SignalingSong Jiang, Xinyan Li, Nicholas J. Hess, Yue Guan, and Richard I. Tapping

3842 AMicroRNA-Mediated Positive Feedback Regulatory Loop of the NF-kB Pathway in Litopenaeus vannameiHongliang Zuo, Jia Yuan, Yonggui Chen, Sedong Li, Ziqi Su, Erman Wei, Chaozheng Li, Shaoping Weng, Xiaopeng Xu,

and Jianguo He

3854 Topical Application of Fingolimod Perturbs Cutaneous InflammationWai Y. Sun, David P. Dimasi, Melissa R. Pitman, YiZhong Zhuang, Robert Heddle, Stuart M. Pitson,

Michele A. Grimbaldeston, and Claudine S. Bonder

3865 Raftlin Controls Lipopolysaccharide-Induced TLR4 Internalization and TICAM-1 Signaling in a CellType–Specific MannerMegumi Tatematsu, Ryuji Yoshida, Yuka Morioka, Noriko Ishii, Kenji Funami, Ayako Watanabe, Kazuko Saeki,

Tsukasa Seya, and Misako Matsumoto

3877 MOV10 Provides Antiviral Activity against RNA Viruses by Enhancing RIG-I–MAVS-IndependentIFN InductionRolando A. Cuevas, Arundhati Ghosh, Christina Wallerath, Veit Hornung, Carolyn B. Coyne, and Saumendra N. Sarkar

3887 Elevated Response to Type I IFN Enhances RANKL-Mediated Osteoclastogenesis in Usp18-KnockoutMiceHwa Young Yim, Cheolkyu Park, Yong Deok Lee, Kei-ichiro Arimoto, Raok Jeon, Sung Hee Baek, Dong-Er Zhang,

Hong-Hee Kim, and Keun Il Kim

MOLECULAR AND STRUCTURAL IMMUNOLOGY3896 The C-Terminal Acidic Region of Calreticulin Mediates Phosphatidylserine Binding and Apoptotic Cell

PhagocytosisSanjeeva Joseph Wijeyesakere, Sukhmani Kaur Bedi, David Huynh, and Malini Raghavan

MUCOSAL IMMUNOLOGY3910 Glucocorticoids Suppress CCR9-Mediated Chemotaxis, Calcium Flux, and Adhesion to MAdCAM-1 in

Human T CellsEmily Wendt, Gemma E. White, Helen Ferry, Michael Huhn, David R. Greaves, and Satish Keshav

3920 IL-15–Independent Maintenance of Tissue-Resident and Boosted Effector Memory CD8 T CellsJason M. Schenkel, Kathryn A. Fraser, Kerry A. Casey, Lalit K. Beura, Kristen E. Pauken, Vaiva Vezys, and David Masopust

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TRANSPLANTATION3927 miR-181a Expression in Donor T Cells Modulates Graft-versus-Host Disease after Allogeneic Bone Marrow

TransplantationChun-Wei Lee, Katharina Wohlan, Iris Dallmann, Reinhold Forster, Arnold Ganser, Andreas Krueger, Michaela Scherr,

Matthias Eder, and Christian Koenecke

TUMOR IMMUNOLOGY3935 Target Density, Not Affinity or Avidity of Antigen Recognition, Determines Adoptive T Cell Therapy

Outcomes in a Mouse Lymphoma ModelGabriela Segal, Sandro Prato, Dietmar Zehn, Justine D. Mintern, and Jose A. Villadangos

NOVEL IMMUNOLOGICAL METHODS3943 Multispectral Imaging of T and B Cells in Murine Spleen and Tumor

Zipei Feng, Shawn M. Jensen, David J. Messenheimer, Mohammed Farhad, Michael Neuberger, Carlo B. Bifulco, and

Bernard A. Fox

3951 A Functionalized Sphingolipid Analogue for Studying Redistribution during Activation in Living T CellsLena Collenburg, Tim Walter, Anne Burgert, Nora Muller, Jurgen Seibel, Lukasz Japtok, Burkhard Kleuser, Markus Sauer,

and Sibylle Schneider-Schaulies

CORRECTIONS

3963 Correction: Immunological Priming Requires Regulatory T Cells and IL-10–Producing Macrophages ToAccelerate Resolution from Severe Lung InflammationNeil R. Aggarwal, Kenji Tsushima, Yoshiki Eto, Ashutosh Tripathi, Pooja Mandke, Jason R. Mock, Brian T. Garibaldi,

Benjamin D. Singer, Venkataramana K. Sidhaye, Maureen R. Horton, Landon S. King, and Franco R. D’Alessio

3966 Correction: CD4+ Group 1 Innate Lymphoid Cells (ILC) Form a Functionally Distinct ILC Subset That IsIncreased in Systemic SclerosisFlorence Roan, Thomas A. Stoklasek, Elizabeth Whalen, Jerry A. Molitor, Jeffrey A. Bluestone, Jane H. Buckner,

and Steven F. Ziegler

3967 Correction: Yeast-Derived Particulate b-Glucan Treatment Subverts the Suppression of Myeloid-DerivedSuppressor Cells (MDSC) by Inducing Polymorphonuclear MDSC Apoptosis and Monocytic MDSCDifferentiation to APC in CancerSabrin H. Albeituni, Chuanlin Ding, Min Liu, Xiaoling Hu, Fengling Luo, Goetz Kloecker, Michael Bousamra, II,

Huang-ge Zhang, and Jun Yan

3968 Correction: Dectin-1 Activation by a Natural Product b-Glucan Converts ImmunosuppressiveMacrophages into an M1-like PhenotypeMin Liu, Fengling Luo, Chuanlin Ding, Sabrin Albeituni, Xiaoling Hu, Yunfeng Ma, Yihua Cai, Lacey McNally,

Mary Ann Sanders, Dharamvir Jain, Goetz Kloecker, Michael Bousamra, II, Huang-ge Zhang, Richard M. Higashi,

Andrew N. Lane, Teresa W.-M. Fan, and Jun Yan

3969 Correction: Targeting of Antigens to B Lymphocytes via CD19 as aMeans for Tumor Vaccine DevelopmentYunfeng Ma, Dong Xiang, Jinwen Sun, Chuanlin Ding, Min Liu, Xiaoling Hu, Guoxin Li, Goetz Kloecker,

Huang-ge Zhang, and Jun Yan

3970 AUTHOR INDEX

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