the sheba medical center sheba.co.il

The Sheba Medical CenterThe Sheba Medical Centerwww.sheba.co.ilwww.sheba.co.il

Sheba Medical Center at Tel Hashomer Israel's National Medical Center

Sheba Medical Center - Facts and Figures Comprises 120 departments and clinics, 1,800 beds,

6,800 healthcare professionals, including 900 doctors and 2,000 nurses.

Comprehensive care - an Acute Care Hospital with a Rehabilitation Hospital, Maternity Hospital, Children's Hospital, Medical Research Laboratory Complex, and an Academic Campus.

1.5 million patient visits a year, including 175,000 emergency visits, 90,000 inpatients and 2 million medical tests each year.

Situated on a 150-acre campus.

Sheba Medical Center at Tel-Hashomer Sheba Medical Center at Tel-Hashomer Israel's National Medical CenterIsrael's National Medical Center

Research at Sheba

3200 researchers, technicians and lab workers 25% of Israeli medical research is performed at Sheba 600 clinical trials per year (200 industry-sponsored) 400 published articles per year The main venue for human clinical trials conducted by the

Weizmann Institute, Tel Aviv and Bar-Ilan universities. 25 M$ /year income from grants, sponsored-research,

donations 81 biomedical patents, 37 licensed patents

Sheba Medical Center at Tel-Hashomer Israel's National Medical Center

Our Research Facilities (Pre-Clinical)

75 laboratories spanning 35,000 m2 area 9 ISO-15189 approved laboratories IVC-SPF small animal facility Zebra fish facility Genomic center equipped with last-generation genome

analyzers and microarray facilities Advanced Microscopy Unit (multiphoton, microdissection,

electron and confocal microscopes) Tissue bank with over 15,000 specimens and depositions from

over 400 new patients per year Fully-automated MegaLab facility performing over 1000

different clinical tests Surgery room for big animals with state-of-the-art equipment

Medical Medical Research Research CentersCentersTTOTTO

IP management & IP management & CommercializationCommercialization

Research & Research & LicensingLicensing

Research Funding Grant coordinator

R&D collaborationsResearch info

R & D R & D UnitUnit

Commercial Commercial Clinical Clinical

Sponsored Sponsored ResearchResearch

AgreementsAgreementsBusinesBusiness s

PartnersPartners

BusinesBusiness s

PartnersPartners

Patent Patent CommitteeCommittee

Sheba Medical CenterSheba Medical CenterResearch and Development PowerhouseResearch and Development Powerhouse

• Research Center for Autoimmune Diseases

• Research Center for Psychiatric and Dementia

• Advanced Technology Center

• Sheba Cancer Research Center

• Regenerative Medicine Research Center

• The Bert W. Strassburger Lipid Center

• The Joseph Sagol Neuroscience Center

• The Leviev Heart Center

• The Multiple Sclerosis Research Center

• Imaging Institute

• Tissue Banking – Research Tools

Sheba Medical CenterSheba Medical Center

Research Centers of ExcellenceResearch Centers of Excellence

Sheba Institutional Tissue Bank The partner to accelerate The partner to accelerate Biomedical ResearchBiomedical Research andand Medical Medical

Product DevelopmentProduct Development through clinical & database resources through clinical & database resources

GIGIProstateProstate

LungsLungs

NasalNasalsinussinus

MelanomaMelanoma

ThymusThymus

PharynxPharynx

ChildrenChildren

ShebaShebaTissueTissueBankBank

BrainBrain

Head andHead andNeckNeck

UrologyUrology

ThoracicThoracicOrthopedicsOrthopedics

GynecologyGynecology

SurgerySurgery

KidneyKidney

BladderBladder

AdrenalAdrenal

ThyroidThyroid LarynxLarynx

BreastBreast

HepatoHepato--biliarbiliar

OvaryOvaryUterusUterus

AllAll solidsolid

tumorstumors‘‘HematoHemato ’ ’

Bm & BxBm & Bx

Research & Development at Research & Development at Sheba Sheba

Collaboration with Research InstitutesCollaboration with Research InstitutesWeizmann Institute of Science

Tel Aviv University

Bar Ilan University

MD Anderson, University of Texas

Cedars-Sinai Medical Center

Mayo Clinic

Cincinnati Children's Hospital Medical Center

The Cleveland Clinic Medical Center

Albert Einstein - Brazil

Commercial & Clinical Studies at Sheba Commercial & Clinical Studies at Sheba

Sheba Medical CenterSheba Medical Center

Period

Helsinki Approval

Commercial Research

Agreement

Research Budget

(M IS)

2009200957357315015018.218.2

2010201057257218818838.438.4

2011201160960922922944.144.1

Competitive Grant Sponsored Research at ShebaCompetitive Grant Sponsored Research at Sheba

Sheba Medical CenterSheba Medical Centera Medical Research a Medical Research

PowerhousePowerhouse

Grant Submission

Period

Submission number

Grants Awarded

% Awarded

Total Fund awarded (NIS/Million)

2008882933%~ 13.2 M

2009822430%~ 19.0 M

20101243327%~ 22.5 M

Technology Transfer at ShebaTechnology Transfer at Sheba• Guided devices for GI tract monitoring• Non-invasive identification of pathologic substances in amiotic fluid• Stem cell subretinal injector

• Cancer treatment by recombinant Klotho, CEACAM1, STIL• Synthetic peptides for APS•Bleeding treatment by Fibrinogen

• Gene signatures for MS management / personalized medicine• Labeled somatostatin analogs• Serum markers for bone maladies

• Automatic classification of X-ray images

• BBB disruption analysis by MRI• On-line assessment of tissue

ablation

Patent CommercializationPatent Commercialization

Sheba Medical CenterSheba Medical CenterTechnology Transfer ActivitiesTechnology Transfer Activities

Activities2002-7200820092010 2011

Patent Application (active) *

Joined Patent

Research & Licensing Agreements

20

7

9

9

8

7

15

8

9

9

5

12

9 (+3)

5

11 (+6)

Medical Device 20% Therapeutics & Drug Delivery 15% Biological Markers 25% Imaging 15% Stem Cells 25% *15 patent applications were abundant

Total Patent Family –89Total Patent Family –89Total Commercial Total Commercial agreements - 42 agreements - 42

Ani-Biofilm compounds for Cleantech and medical applicationsAni-Biofilm compounds for Cleantech and medical applications

HUTCHISON WHAMPOA LIMITEDHUTCHISON WHAMPOA LIMITED

Novel Therapy for BlindnessNovel Therapy for Blindness & Psoriasis

NIKKEN SOHONSHA CorporationNIKKEN SOHONSHA Corporation

Production of antibodies to cellular proteinsProduction of antibodies to cellular proteins

SIGMA-ALDRICH ISRAEL Ltd

Antibodies to treat Melanoma

PONTIFAX and F. HOFFMANN-LA ROCHE Ltd.

Aortic Valve ImplantationAortic Valve Implantation

VENTOR-MEDTRONICVENTOR-MEDTRONIC

Convection-Enhanced Drug Delivery and MRI MonitoringConvection-Enhanced Drug Delivery and MRI Monitoring Schering-PloughSchering-Plough

Apparatus for guiding medical devices in the GIApparatus for guiding medical devices in the GI

I. P. U Industrial, IsraelI. P. U Industrial, Israel


Collaboration with the IndustryCollaboration with the Industry


Collaboration with the IndustryCollaboration with the IndustryHigh-intensity focused ultrasound

InSightec

Antibodies to FRZ 7Antibodies to FRZ 7SigmaSigma

SiRNA to STIL gene – cancer treatmentSiRNA to STIL gene – cancer treatmentBiolineBioline

miRNA for Cancer DiagnosticmiRNA for Cancer DiagnosticROSETTA GENOMICSROSETTA GENOMICS

Stem Cell Therapy for Renal Failure Stem Cell Therapy for Renal Failure Wolfson Clore Mayer VCWolfson Clore Mayer VC

Novel Papilometer – Field View AnalysisNovel Papilometer – Field View Analysis ACCUTOMEACCUTOME

Spinoff CompaniesSpinoff Companies• Nephrostem – Nephrostem – cell therapy to treat renal failurecell therapy to treat renal failure

• CCAM Medical – CCAM Medical – novel treatment for melanomanovel treatment for melanoma

• MitralHeal - MitralHeal - transapical mitral valvetransapical mitral valve

• Amniotix - Amniotix - spectral analysis of amniotic fluidspectral analysis of amniotic fluid

• Radiologic - Radiologic - Automatic medical imaging analysisAutomatic medical imaging analysis

• Selpix - Selpix - novel hair removing devicenovel hair removing device

• TopDyn - TopDyn - multiple sclerosis disease managementmultiple sclerosis disease management

• Orgenesis - Orgenesis - cell therapy to treat diabetescell therapy to treat diabetes

Monitoring Ablation of Tissues

Guiding Medical Devices in the Gastrointestinal Tract

Improved Electron Radiotherapy

Identification of Meconium in Amniotic Fluid

Novel diagnostic pill for GI applications

Objective Chromatic Perimetry Analysis Using Pupillometer

THM IP PortfolioTHM IP Portfolio


METHOD AND DEVICE FOR DETECTION OF ABNORMALITIES OF THE GASTROINTESTINAL TRACT

Subretinal Injection Device

Methods and Devices Suitable for Imaging Blood-Containing Tissue

Transapical Mitral Valve

Left Atrial Appendage Intra-atrial Clip

Colostomy Ileostomy Automatic Stapler Device

Klotho: Tumor suppressor of breast and pancreatic Klotho: Tumor suppressor of breast and pancreatic

cancerscancers

Targeting CEACAM1 for Cancer TherapyTargeting CEACAM1 for Cancer Therapy

Anti-Cancer Treatment - siRNA to STIL Anti-Cancer Treatment - siRNA to STIL

Somatostatin Analogs – Platform for targeting DrugsSomatostatin Analogs – Platform for targeting Drugs

Cardiac Scar Rejuvenation by Chemical PeelingCardiac Scar Rejuvenation by Chemical Peeling

Synthetic Peptide For Antiphospholipid SyndromeSynthetic Peptide For Antiphospholipid Syndrome

Cancer Treatment with Exendin 4Cancer Treatment with Exendin 4

Bleeding Treatment by FibrinogenBleeding Treatment by Fibrinogen

Targeting Multiple Sclerosis - Si RNA to specific Target Targeting Multiple Sclerosis - Si RNA to specific Target

genesgenes

Specific microRNAs (miRNA) selection for psoriasis Specific microRNAs (miRNA) selection for psoriasis

treatmenttreatment

Novel Target to treat Cancer Stem CellsNovel Target to treat Cancer Stem Cells


Transcriptional Signatures for Multiple Sclerosis Management

Gene Signatures for Brain Metastasis Prediction

Methods and Kits for Determining Predisposition to Warfarin Resistance

Human Serum markers for Bone Formation and Bone Maladies

Somatostatin analog for Cancer Diagnosis and Treatment

Trophoblast Markers for non-invasive Prenatal Diagnosis

Methyl-Tetrahydrofolate homocystein Methyl Transferase –

MTR as a marker for autoimmune diseases

Klotho Mutations in Breast Cancer


Stem Cell Therapy for Renal FailureStem Cell Therapy for Renal Failure

Cell Therapy for DiabetesCell Therapy for Diabetes

Stem Cells for Cardiac ApplicationsStem Cells for Cardiac Applications

Recovery of all stem, progenitor and regenerative cellsRecovery of all stem, progenitor and regenerative cells

Enrichment and Expansion of Human Stem CellsEnrichment and Expansion of Human Stem Cells from peripheral blood and umbilical vein cord bloodfrom peripheral blood and umbilical vein cord blood


Automatic Analysis of X-rays by “Bag of Visual Words” Algorithm

Method and System for Monitoring Ablation of Tissues

BBB Disruption Assessment by MRI


Drug Discovery Platform for MS DrugsDrug Discovery Platform for MS Drugs

Methods for Silencing Gene expressionMethods for Silencing Gene expression

In vivo Tool to Identify Novel Targets in Health and Disease In vivo Tool to Identify Novel Targets in Health and Disease useful for Drug Screening based on useful for Drug Screening based on A-I RNA editing A-I RNA editing

ERG transgenic mouse - a platform for preclinical studies of ERG transgenic mouse - a platform for preclinical studies of novel therapeuticsnovel therapeutics

Immunoassay for Monitoring Patient’s Response to Biological Immunoassay for Monitoring Patient’s Response to Biological DrugsDrugs

Dynamic Contrast MRI for assessment of Blood Brain BarrierDynamic Contrast MRI for assessment of Blood Brain Barrier

Convection – Enhanced Drug Delivery Convection – Enhanced Drug Delivery

Small Scale Affinity Method for Biomarker Enrichment in Small Scale Affinity Method for Biomarker Enrichment in Human SerumHuman Serum


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