the triple helix how this innovation model has supported the success of mds sciex bill davidson may...
TRANSCRIPT
![Page 1: The Triple Helix How This Innovation Model has Supported the Success of MDS Sciex Bill Davidson May 10, 2006](https://reader033.vdocuments.net/reader033/viewer/2022051614/551accbc55034656628b5f16/html5/thumbnails/1.jpg)
The Triple HelixHow This Innovation Model has
Supported the Success of MDS Sciex
Bill DavidsonMay 10, 2006
![Page 2: The Triple Helix How This Innovation Model has Supported the Success of MDS Sciex Bill Davidson May 10, 2006](https://reader033.vdocuments.net/reader033/viewer/2022051614/551accbc55034656628b5f16/html5/thumbnails/2.jpg)
MDS Sciex
• World’s largest manufacturer of mass spectrometers in the life sciences market
• >$550M in end-user revenues
• 550 employees in three sites, 230 staff in R&D
• $50M R&D budget
• Joint Venture with Applied Biosystems• MS/MS, Linear Trap, QqTOF, TOF/TOF
• Joint Venture with PerkinElmer• ICP/MS and prO-TOF
• Just launched first non-MS product – the CellKey cell analysis system
![Page 3: The Triple Helix How This Innovation Model has Supported the Success of MDS Sciex Bill Davidson May 10, 2006](https://reader033.vdocuments.net/reader033/viewer/2022051614/551accbc55034656628b5f16/html5/thumbnails/3.jpg)
What is the Triple Helix?
Triple Helix Piano Trio
![Page 4: The Triple Helix How This Innovation Model has Supported the Success of MDS Sciex Bill Davidson May 10, 2006](https://reader033.vdocuments.net/reader033/viewer/2022051614/551accbc55034656628b5f16/html5/thumbnails/4.jpg)
What is the Triple Helix?
The Triple Helix Rock Band
![Page 5: The Triple Helix How This Innovation Model has Supported the Success of MDS Sciex Bill Davidson May 10, 2006](https://reader033.vdocuments.net/reader033/viewer/2022051614/551accbc55034656628b5f16/html5/thumbnails/5.jpg)
What is the Triple Helix?
University
Government
Industry
![Page 6: The Triple Helix How This Innovation Model has Supported the Success of MDS Sciex Bill Davidson May 10, 2006](https://reader033.vdocuments.net/reader033/viewer/2022051614/551accbc55034656628b5f16/html5/thumbnails/6.jpg)
Funding &Strategic Needs
New Product Concepts
Diagram of How it Works
Industry Government
Academia
Employment, Taxes, Benefits to Citizens
![Page 7: The Triple Helix How This Innovation Model has Supported the Success of MDS Sciex Bill Davidson May 10, 2006](https://reader033.vdocuments.net/reader033/viewer/2022051614/551accbc55034656628b5f16/html5/thumbnails/7.jpg)
Benefits to Industry
• Expand long term and risky research activities to experts in the field
• Obtain proprietary technology through licensing agreements
• Leverage funding through matching grant projects
• Collaborating research labs are source of new recruits
![Page 8: The Triple Helix How This Innovation Model has Supported the Success of MDS Sciex Bill Davidson May 10, 2006](https://reader033.vdocuments.net/reader033/viewer/2022051614/551accbc55034656628b5f16/html5/thumbnails/8.jpg)
Benefits to Academia
• Excellent source of funding with industry and government sharing the load
• Funding allows for critical mass of personnel and in general more efficient research
• Training of highly qualified personnel in industrial related research good for job placements
• Helps remove stigma of “ivied walls”
• Research generally based on strategic needs and has long range benefit to the community
![Page 9: The Triple Helix How This Innovation Model has Supported the Success of MDS Sciex Bill Davidson May 10, 2006](https://reader033.vdocuments.net/reader033/viewer/2022051614/551accbc55034656628b5f16/html5/thumbnails/9.jpg)
Benefits to Government
• New industries and new products can lead to higher employment
• Financial benefit from taxes and duties
• Helps support strategic R&D initiatives
• Many products have impact on Canadians in providing a better live style
![Page 10: The Triple Helix How This Innovation Model has Supported the Success of MDS Sciex Bill Davidson May 10, 2006](https://reader033.vdocuments.net/reader033/viewer/2022051614/551accbc55034656628b5f16/html5/thumbnails/10.jpg)
Success Stories
![Page 11: The Triple Helix How This Innovation Model has Supported the Success of MDS Sciex Bill Davidson May 10, 2006](https://reader033.vdocuments.net/reader033/viewer/2022051614/551accbc55034656628b5f16/html5/thumbnails/11.jpg)
Development of TAGA 6000
An Mobile Taga 6000 for Environmental Monitoring
Taga 6000 (1980)
![Page 12: The Triple Helix How This Innovation Model has Supported the Success of MDS Sciex Bill Davidson May 10, 2006](https://reader033.vdocuments.net/reader033/viewer/2022051614/551accbc55034656628b5f16/html5/thumbnails/12.jpg)
Parties Involved• Academia
• University of Toronto Aerospace Institute, Barry French who had had expertise in ion optics in free jet expansion
• Government• National Research Council, Peter Dawson who had
world leading expertise in quadrupole design• Department of Industry (PILP program)
• Industry• Sciex Inc.
![Page 13: The Triple Helix How This Innovation Model has Supported the Success of MDS Sciex Bill Davidson May 10, 2006](https://reader033.vdocuments.net/reader033/viewer/2022051614/551accbc55034656628b5f16/html5/thumbnails/13.jpg)
Outcome
• The TAGA 6000 was the first commercial triple quadrupole mass spectrometer
• Introduced in 1980, it was the foundation for Sciex’s commercial success
• Sciex now is world leader in production of triple quadrupole
• Major source of licensing revenue for the NRC and U of T
• Led to thousand of Canadian jobs
• Off-spring products now used in development of drugs, neonatal and other clinical screening
![Page 14: The Triple Helix How This Innovation Model has Supported the Success of MDS Sciex Bill Davidson May 10, 2006](https://reader033.vdocuments.net/reader033/viewer/2022051614/551accbc55034656628b5f16/html5/thumbnails/14.jpg)
Development of ELAN 250
![Page 15: The Triple Helix How This Innovation Model has Supported the Success of MDS Sciex Bill Davidson May 10, 2006](https://reader033.vdocuments.net/reader033/viewer/2022051614/551accbc55034656628b5f16/html5/thumbnails/15.jpg)
Parties Involved
• University of Toronto Institute for Aerospace Studies• Dr. Barry French who had expertise in interfacing
atmospheric pressure ion sources with MS• MDS Sciex
• Dr. Don Douglas who was the first to accomplish this interface.
• National Research Council• Dr. Jim McLaren who was a leader in elemental analysis
• Department of Industry
![Page 16: The Triple Helix How This Innovation Model has Supported the Success of MDS Sciex Bill Davidson May 10, 2006](https://reader033.vdocuments.net/reader033/viewer/2022051614/551accbc55034656628b5f16/html5/thumbnails/16.jpg)
Outcome
• The Elan 250 was the first commercial ICP/MS used for trace element detection
• It proved to be the catalyst in the formation of a joint venture between Sciex and Perkin Elmer
• Market now include: clinical, environmental, semi-conductor, homeland security, medical research
![Page 17: The Triple Helix How This Innovation Model has Supported the Success of MDS Sciex Bill Davidson May 10, 2006](https://reader033.vdocuments.net/reader033/viewer/2022051614/551accbc55034656628b5f16/html5/thumbnails/17.jpg)
More Outcomes
• NRC became the first user of technique and used it to develop calibration standards
• NRC received royalties as repayment of government grant
• Several hundred jobs created over the years
• Diversified Sciex’s product line and kept company alive in the mid-80s
![Page 18: The Triple Helix How This Innovation Model has Supported the Success of MDS Sciex Bill Davidson May 10, 2006](https://reader033.vdocuments.net/reader033/viewer/2022051614/551accbc55034656628b5f16/html5/thumbnails/18.jpg)
Development of ELAN 6000 and API 300
![Page 19: The Triple Helix How This Innovation Model has Supported the Success of MDS Sciex Bill Davidson May 10, 2006](https://reader033.vdocuments.net/reader033/viewer/2022051614/551accbc55034656628b5f16/html5/thumbnails/19.jpg)
Parties Involved
• University of Toronto Institute for Aerospace Studies
• Dr. Barry French• Several Sciex scientists seconded to UTIAS
• MDS Sciex
• Perkin Elmer
• Ontario Technology Fund
![Page 20: The Triple Helix How This Innovation Model has Supported the Success of MDS Sciex Bill Davidson May 10, 2006](https://reader033.vdocuments.net/reader033/viewer/2022051614/551accbc55034656628b5f16/html5/thumbnails/20.jpg)
Outcomes
• API 300 became the platform triple quadrupole system for MDS Sciex and with high margins led to added profitability
• Elan 6000 also became the platform ICP/MS, and became the market leader in elemental analysis
• $17M government investment has lead to over $3B in revenues
![Page 21: The Triple Helix How This Innovation Model has Supported the Success of MDS Sciex Bill Davidson May 10, 2006](https://reader033.vdocuments.net/reader033/viewer/2022051614/551accbc55034656628b5f16/html5/thumbnails/21.jpg)
More Outcomes
• This project became the “model” project for believers in the triple helix model of innovation
• It gave MDS Sciex the ability to compete globally and led to our success in the industry
• UTIAS students and post-docs went on to excellent positions in industry and academia
• OTF didn’t fair well and was stopped when Conservatives took power
![Page 22: The Triple Helix How This Innovation Model has Supported the Success of MDS Sciex Bill Davidson May 10, 2006](https://reader033.vdocuments.net/reader033/viewer/2022051614/551accbc55034656628b5f16/html5/thumbnails/22.jpg)
Development of QStar and o-MALDI
Centaur
![Page 23: The Triple Helix How This Innovation Model has Supported the Success of MDS Sciex Bill Davidson May 10, 2006](https://reader033.vdocuments.net/reader033/viewer/2022051614/551accbc55034656628b5f16/html5/thumbnails/23.jpg)
Parties Involved• University of Manitoba
• Dr. Ken Standing and Werner Ens, experts in time-of-flight (TOF) technology
• MDS Sciex
• Dr. Bruce Thomson and others, experts in quadrupole technology
• Applied Biosystems
• Institute for Marine Biosciences
• Dr. Bob Boyd and others, experts in the use of MS in bioanalytical work
• NSERC
![Page 24: The Triple Helix How This Innovation Model has Supported the Success of MDS Sciex Bill Davidson May 10, 2006](https://reader033.vdocuments.net/reader033/viewer/2022051614/551accbc55034656628b5f16/html5/thumbnails/24.jpg)
Outcomes
• The QStar was the first TOF instrument developed by MDS Sciex
• It is now a key product in biomarker discover and protein identification
• o-MALDI proved to be a powerful tool in proteomics and now is used to tissue imaging, high throughput assays
• U of Manitoba and Sciex were awarded an NSERC Synergy Award for this project
![Page 25: The Triple Helix How This Innovation Model has Supported the Success of MDS Sciex Bill Davidson May 10, 2006](https://reader033.vdocuments.net/reader033/viewer/2022051614/551accbc55034656628b5f16/html5/thumbnails/25.jpg)
More Outcomes
• Royalties and other licensing fees were a major source of revenue for U Manitoba (and still are)
• U Manitoba became key player in proteomics arena
• Key member of Sciex’s present research group came from U Manitoba and IMB
• This is also viewed as a model of how academia, industry and government projects can be beneficial to all
![Page 26: The Triple Helix How This Innovation Model has Supported the Success of MDS Sciex Bill Davidson May 10, 2006](https://reader033.vdocuments.net/reader033/viewer/2022051614/551accbc55034656628b5f16/html5/thumbnails/26.jpg)
When Projects are Successful
Industry
Academia
Government
![Page 27: The Triple Helix How This Innovation Model has Supported the Success of MDS Sciex Bill Davidson May 10, 2006](https://reader033.vdocuments.net/reader033/viewer/2022051614/551accbc55034656628b5f16/html5/thumbnails/27.jpg)
Not So Successful
![Page 28: The Triple Helix How This Innovation Model has Supported the Success of MDS Sciex Bill Davidson May 10, 2006](https://reader033.vdocuments.net/reader033/viewer/2022051614/551accbc55034656628b5f16/html5/thumbnails/28.jpg)
DNA Sequencer
The Applied Biosystems Prism 3700
![Page 29: The Triple Helix How This Innovation Model has Supported the Success of MDS Sciex Bill Davidson May 10, 2006](https://reader033.vdocuments.net/reader033/viewer/2022051614/551accbc55034656628b5f16/html5/thumbnails/29.jpg)
Parties Involved
• University of Alberta• Dr. Norm Dovichi, expert in capillary electrophoresis
• Genetic Disease Network
• Bacterial Disease Network
• MDS Sciex
• NSERC
![Page 30: The Triple Helix How This Innovation Model has Supported the Success of MDS Sciex Bill Davidson May 10, 2006](https://reader033.vdocuments.net/reader033/viewer/2022051614/551accbc55034656628b5f16/html5/thumbnails/30.jpg)
Outcomes
• ILO office late in patenting certain aspects of the technology
• MDS Sciex unable to commercialize product
• Applied Biosystems licenses technology from Sciex and creates the first high throughput, capillary based DNA sequencer
• This technology led to the sequencing of the Human Genome
• Job creation in Canada less than 5 sales persons.
![Page 31: The Triple Helix How This Innovation Model has Supported the Success of MDS Sciex Bill Davidson May 10, 2006](https://reader033.vdocuments.net/reader033/viewer/2022051614/551accbc55034656628b5f16/html5/thumbnails/31.jpg)
What went wrong
• University under-estimated value of the technology
• MDS Sciex did not have the resource base to commercialize a non-MS product
• Applied Biosystems had other key patents in place that restricted Sciex
• Dovichi became under-funded, and went to the US
![Page 32: The Triple Helix How This Innovation Model has Supported the Success of MDS Sciex Bill Davidson May 10, 2006](https://reader033.vdocuments.net/reader033/viewer/2022051614/551accbc55034656628b5f16/html5/thumbnails/32.jpg)
MS Protein Sequencer
The Toby Project
![Page 33: The Triple Helix How This Innovation Model has Supported the Success of MDS Sciex Bill Davidson May 10, 2006](https://reader033.vdocuments.net/reader033/viewer/2022051614/551accbc55034656628b5f16/html5/thumbnails/33.jpg)
Parties Involved
• Biomedical Research Centre (University of British Columbia)
• Dr. Ruedi Abersold, a leader in protein characterization
• MDS Sciex
• Industry Canada
![Page 34: The Triple Helix How This Innovation Model has Supported the Success of MDS Sciex Bill Davidson May 10, 2006](https://reader033.vdocuments.net/reader033/viewer/2022051614/551accbc55034656628b5f16/html5/thumbnails/34.jpg)
Outcome
• Three prototypes were built but no commercial product was ever made
• Industry Canada did not receive any of its investment back
• Technology worked, but overtaken by other MS approaches (also developed by MDS Sciex)
![Page 35: The Triple Helix How This Innovation Model has Supported the Success of MDS Sciex Bill Davidson May 10, 2006](https://reader033.vdocuments.net/reader033/viewer/2022051614/551accbc55034656628b5f16/html5/thumbnails/35.jpg)
What went wrong
• Acceptance of the technology was slow since all funding was directed towards DNA sequencing at the time
• Wellcome foundation pulls out of BRC and some funding disappears
• The complexity of the technology made it somewhat unattractive
• With BRC transferring to UBC, funding becomes a problem and Ruedi Aebersold leaves for U Washington
![Page 36: The Triple Helix How This Innovation Model has Supported the Success of MDS Sciex Bill Davidson May 10, 2006](https://reader033.vdocuments.net/reader033/viewer/2022051614/551accbc55034656628b5f16/html5/thumbnails/36.jpg)
Lack of Government Funding Leads to “Separation”
Canadian Researcher
FundingAgency
![Page 37: The Triple Helix How This Innovation Model has Supported the Success of MDS Sciex Bill Davidson May 10, 2006](https://reader033.vdocuments.net/reader033/viewer/2022051614/551accbc55034656628b5f16/html5/thumbnails/37.jpg)
Genome Canada
![Page 38: The Triple Helix How This Innovation Model has Supported the Success of MDS Sciex Bill Davidson May 10, 2006](https://reader033.vdocuments.net/reader033/viewer/2022051614/551accbc55034656628b5f16/html5/thumbnails/38.jpg)
Competitions• Competition II
• MDS Sciex and Genome Prairie team up to “Develop Enabling Technologies for Proteomics Research”
• Competition – Human Health• University Hospital Network, MDS Sciex and Ontario
Genomics Institute successful in “Development of MS-based Cytometers for Stem Cell Research”
• Competition III• MDS Sciex, Genome Prairie and Mt. Sinai Hospital propose
to develop new tools for biomarker discovery and validation
![Page 39: The Triple Helix How This Innovation Model has Supported the Success of MDS Sciex Bill Davidson May 10, 2006](https://reader033.vdocuments.net/reader033/viewer/2022051614/551accbc55034656628b5f16/html5/thumbnails/39.jpg)
Outcomes• Competition II
• Project used as an example to parliament as to the value of large-scale projects involving the triple helix
• Competition – Human Health• MDS Sciex backs out of major funding due to high
commercial risk. Sciex researchers form new company to continue project.
• Competition III• Although reviews were excellent, having commercial
company lead the project was likely the reason for the project being reject. Outcome of Sponsorship-gate.
![Page 40: The Triple Helix How This Innovation Model has Supported the Success of MDS Sciex Bill Davidson May 10, 2006](https://reader033.vdocuments.net/reader033/viewer/2022051614/551accbc55034656628b5f16/html5/thumbnails/40.jpg)
In Conclusion
![Page 41: The Triple Helix How This Innovation Model has Supported the Success of MDS Sciex Bill Davidson May 10, 2006](https://reader033.vdocuments.net/reader033/viewer/2022051614/551accbc55034656628b5f16/html5/thumbnails/41.jpg)
Benefits to Triple Helix
• New technologies and products arising from university research
• Training of HQP to support industrial R&D in Canada
• Licensing revenues for Universities
• Job creation for Canadians
• Products lead to higher living standards
• Allows Canadian academia and industry to compete globally
![Page 42: The Triple Helix How This Innovation Model has Supported the Success of MDS Sciex Bill Davidson May 10, 2006](https://reader033.vdocuments.net/reader033/viewer/2022051614/551accbc55034656628b5f16/html5/thumbnails/42.jpg)
Pitfalls to Triple Helix
• A highly successful research project may lead to difficulties in technology transfer
• There are very few government funding opportunities, particularly if industry is not willing to match funds by greater than 50%
• Industry may not have the resources to commercialize the technology
• In highly competitive areas, IP issues can jeopardize commercialization plans