Vol. 267, No. 31 The Journal of November 5, 1992

Biological Chemistry Copyright 0 1992 by the American Society for Biochemistry and Molecular Biology, Inc.

428 East Preston St., Baltimore, MD 21202 U.S.A.

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cor MINIREVIEW

Transcriptional regulation of heat shock genes. A par- adigm for inducible genomic responses. Richard I . Mori- moto, Kevin D. Surge, and Klara Abrauaya

COMMUNICATIONS Identification of intramolecular interactions in adre- nergic receptors. Sankuratri Suryanarayana, Mark uon Zas- trow, and Brian K. Kobilka

Enhancement of membrane insertion and function in a type IIIb membrane protein following introduction of a cleavable signal peptide. Xiao-Ming Guan, Tong Sun Kobilka, and Brian K. Kobilka

The Wilms’ tumor gene product, WT1, represses tran- scription of the platelet-derived growth factor A-chain gene. Zhao Y i Wang, Stephen L. Madden, Thomas F. Deuel, and Frank J . Rauscher III

Purification of 2,3-oxidosqualene cyclase from rat liver. William R. Moore and Gerald L. Schatzman

Electrogenic uptake of y-aminobutyric acid by a cloned transporter expressed in Xenopus oocytes. Michael P. Kauanaugh, Jeffrey L. Arriza, R. Alan North, and Susan G. Amara

Ligand-dependent synergy of thyroid hormone and ret- inoid X receptors. Evan D. Rosen, Amy L. O’Donnell, and Ronald J. Koenig

HI by replacing left-handed helical Lyses with Gly or Thermostabilization of Escherichia coli ribonuclease

Nakamura Asn. Shigenobu Kimura, Shigenori Kanaya, and Haruki

Enhanced GTPase activity of transducin when bound to cGMP phosphodiesterase in bovine retinal rods. Frederique Pages, Philippe Deterre, and Claude Pfister

ARTICLES

bination in myoglobin. An experimental and molecular Distal pocket residues affect picosecond ligand recom-

dynamics study of position 29 mutants. Quentin H. Gib- son, Rebecca Regan, Ron Elber, John s. Olson, and Theodore E. Caruer

Down-regulation of interleukin 6 receptors of mouse myelomonocytic leukemic cells by leukemia inhibitory

Hirayoshi, Kiyoshi Yasuknwa, Minoru Okuma, and Kazuhiro factor. Masahiro Yamaguchi, Masahiro Michishita, Kazunori

Nagata

The stereospecific interaction between chlorophylls and chlorophyllase. Possible implication for chloro-

Rosenbach-Belkin, and Auigdor Scherz phyll biosynthesis and degradation. Leszek Fiedor, Varda

Reversible membrane association of neutrophil 5-li- poxygenase is accompanied by retention of activity and a change in substrate specificity. Elizabeth Hill, Jacques Maclouf, Robert C. Murphy, and Peter M. Henson

binding proteins by photoaffinity labeling and fluores- Identification of actin and HSP 70 as cyclosporin A

cence displacement assays. Marcia L. Moss, Rick E. Palmer, Petr KuzmiE, Brian E. Dunlap, William Henzel, James L.

Rich Kofron, William 5’. Mellon, Catherine A. Royer, and Daniel H.

Parallel control of hepatic proteolysis by phenylalanine and phenylpyruvate through independent inhibitory

Poso, and Glenn E. Mortimore sites at the plasma membrane. Motoni Kadowaki, A. Reeta

JTENTS*

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Control of hepatic proteolysis by leucine and isovaleryl- L-carnitine through a common locus. Evidence for a possible mechanism of recognition at the plasma mem- brane. Giouanni Miotto, Rina Venerando, Kamal K. Khurana, Noris Siliprandi, and Glenn E. Mortimore

The lymphoma transmembrane glycoprotein GP85 (CD44) is a novel guanine nucleotide-binding protein which regulates GP85 (CD44)-ankyrin interaction. Vinata B. Lokeshwar and Lilly Y. W. Bourguignon

L-Threonine transport in pig jejunal brush border membrane vesicles. Functional characterization of the unique system B in the intestinal epithelium. Dauid D. Maenz and John F. Patience

Lactose transport system of Streptococcus thermophi- lus. Functional reconstitution of the protein and char- acterization of the kinetic mechanism of transport. Catherine Foucaud and Bert Poolman

The reversible and irreversible autophosphorylations

Jules A. Shafer of insulin receptor kinase. Lawrence S. Argetsinger and

The regulation of the human tumor necrosis factor a promoter region in macrophage, T cell, and B cell lines. Kristina L. Rhoades, Sidney H. Golub, and James S. Economou

lus licheniformis. In-Cheol Kim, Jae-Ho Cha, Jung-Ryul Catalytic properties of the cloned amylase from BaciZ-

Kim, So-Young Jang, Byung-Cheol Seo, Tae-Kyou Cheong, Due Si1 Lee, Yang Do Choi, and Kwan-Hwa Park

antidiuretic hormone water channel proteins of M, Purification and partial characterization of candidate

55,000 and 53,000 from toad urinary bladder. H. Wil- liam Harris, Jr., Christine Hosselet, Lisa Guay- Woodford, and Mark L. Zeidel

1.9-A resolution structure of fasciculin 1, an anti-ace- tylcholinesterase toxin from green mamba snake venom, Marie H. le Du, Pascale Marchot, Pierre E. Bougis, and Juan C. Fontecilla-Camps

Alternative exon usage and processing of the major histocompatibility complex-encoded proteasome sub- units. Klaw Fruh, Young Yang, Daniele Arnold, James Cham- bers, Lin Wu, James B. Waters, Thomas Spies, and Per A. Peterson

On the mechanisms of the formation of L-alloisoleucine and the 2-hydroxy-3-methylvaleric acid stereoisomers from L-isoleucine in maple syrup urine disease patients and in normal humans. Orval A. Mamer and Mark L. J . Reimer

Negative complementation in aspartate transcarbam-

different arrangements of polypeptide chains from ylase. Analysis of hybrid enzyme molecules containing

wild-type and inactive mutant catalytic subunits. Ed- ward Eisenstein, Min S. Han, Tammy S. Woo, James M. Ritchey, Ian Gibbons, Ying R. Yang, and H. K. Schachman

Basic fibroblast growth factor is internalized through both receptor-mediated and heparan sulfate-mediated mechanisms. Monireh Roghani and Dauid Moscatelli

Glycophorin A facilitates the expression of human band 3-mediated anion transport in Xenopus oocytes. Jona- than D. Groves and Michael J. A. Tanner

Insulin stimulation of phosphatidylinositol 3-kinase ac- tivity and association with insulin receptor substrate 1

J . A. Saad, Jonathnn M. Backer, and C. Ronald Kahn in liver and muscle of the intact rat. Franc0 Folli, Mario

* The CONTENTS arranged by Subject Categories will be found immediately following these CONTENTS. Full Instructions to Authors will be found in (1992) J . Biol. Chem. 267, 13781-13789, and reprints may be obtained from the editorial office.

111 ...

V

22178 Selective inhibition of proliferation in v-abl- and bcr-

Sunil Mukhopadhyay, and Gwuanni Rouera obl-transformed cells by a nucleoside analog. Liuia Cioe,

22183 Reversal of the desensitized state of pig ovarian follic- ular human choriogonadotropin-sensitive adenylylcy- clase by guanosine 5'-0-(2-thiodiphosphate). Richard C. Ekstrom, Ellen M. Carney, Marilyn L. G. Lamm, and Mary Hunzicker-Dum

22190 Interleukin-1-inducible genes in endothelial cells.

serum amyloid P component. Ferruccio Breuiario, Elisa- Cloning of a new gene related to C-reactive protein and

betta M. d'Aniello, Josee Golay, Giuseppe Peri, Barbara Bot-

entina Predazzi, Mariano Rocchi, Giuliano Della Valle, Elisa- tozzi, Amos Bairoch, Salvatore Saccone, Rosalia Marzella, Val-

betta Dejana, Alberta Mantouani, and Martino Introna

22198 The identification of a domain in Escherichia coli elon- gation factor Tu that interacts with elongation factor Ts. Yu- Wen Hwang, Mary Carter, and Dauid L. Miller

22206 Tissue factor residues 167-167 are required for effi- cient proteolytic activation of factor X and factor VII.

Thomas S. Edgington Wolfram Ruf, Dauid J. Miles, Alnawaz Rehemtulla, and

22211 Characterization of a gain of function mutation of in- tegrin a d 3 (platelet glycoprotein IIb-IIIa). Mary Lynn

Ginsberg Bajt, Joseph C. Loftus, Meinrad P. Gawaz, and Mark H.

22217 Selenomethionyl dihydrofolate reductase from Esche- richia coli. Comparative biochemistry and "Se nuclear magnetic resonance spectroscopy. Jeffrey 0. Boles, W. H.

Odom Tolleson, Jeanne C. Schmidt, R. Bruce Dunlap, and Jerome D.

22289 The three-dimensional structures of methanol dehydro- genase from two methylotrophic bacteria at 2.6-A

Zhi-ping Hao, Victor L. Dauidson, Scott White, and F. Scott resolution. Zong-xinng Xia, Wei-wen Dai, Jian-ping Xiong,

Mathews

22298 Identification of a glycine-rich sequence as an NAD(P)H-binding site and Tyrosine 128 as a dicu- marol-binding site in rat liver NAD(P)Hquinone oxi- doreductase by site-directed mutagenesis. Qiang Ma, Kunyuan Cui, Fang Xiao, Anthony Y. H. Lu, and Chung S. Yang

22305 Identification of xenin, a xenopsin-related peptide, in the human gastric mucosa and its effect on exocrine pancreatic secretion. Gerhard E. Feurle, Gerd Hamscher, Reinhard Kusiek, Helmut E. Meyer, and Jorg W. Metzger

22310 Affinity purification and characterization of myristoy- lated alanine-rich protein kinase C substrate (MARCKS) from bovine brain. Comparison of the

Manenti, Odile Sorokine, Alain Van Dorsselaer, and Hisaaki cytoplasmic and the membrane-bound forms. Stkphane

Taniguchi

22316 Kinetics of Ca2+ release and contraction induced by photolysis of caged D-myo-inositol 1,4,5-trisphosphate

adenine nucleotides. Auril V. Somlyo, Keisuke Horiuti, in smooth muscle. The effects of heparin, procaine, and

Dauid R. Trentham, Toshio Kitazawa, and Andrew P. Somlyo

22323 Phosphate transport by capillaries of the blood-brain barrier. Lise Dallaire and Richard BQliueau

22328 Glutaraldehyde cross-links Lys-492 and Arg-678 at

Dauid B. McIntosh the active site of sarcoplasmic reticulum CaZ+-ATPase.

22224 The role of the COOH-terminal region of antithrombin 22336 The CCAATIenhancer-binding protein trans-activates 111. Evidence that the COOH-terminal region of the the human cholesteryl ester transfer protein gene pro- inhibitor enhances the reactivity of thrombin and fac- moter. Luis B. Agellon, Peiquan Zhang, Xian Cheng Jiang, tor Xa with the inhibitor. Junji Nishioku and Koji Suzuki Laurel Mendelsohn, and Alan R. Tall

22230 Crystal structure disposition of thymidylic acid tetra- mer in complex with ribonuclease A. Dauid L. Birdsall and Alexander McPherson

22237 Identification of the essential histidine residue at the active site of Escherichia coli dehydroquinase. Ranjit K. Deka, Colin Kleanthous, and John R. Coggins

22243 Reversible, nonionic, and pH-dependent association of cytochrome c with cardiolipin-phosphatidylcholine li- posomes. Marjatta Rytomaa, Pekka Mustonen, and Paauo K. J . Kinnunen

22249 Agonist-induced phosphorylation and desensitization of human m2 muscarinic cholinergic receptors in Sf9 insect cells. Ricardo M. Richardson and M. Marlene Hosey

22340 Purification and characterization of inositol-1,3,4- trisphosphate 5/6-kinase from rat liver using an inosi- tol hexakisphosphate affinity column. Munir Abdullah, Philip J . Hughes, Andrew Craxton, Roy Gigg, T. Desai, James F. Marecek, Glenn D. Prestwich, and Stephen B. Shears

22346 COMP (cartilage oligomeric matrix pro$ein) is struc- turally related to the thrombospondins. Ake Oldberg, Per Antonsson, Karin Lindblom, and Dick Heinegiird

22351 Insertion of an intracisternal A particle within the 5'-

protein in L1210 leukemia cells in response to low regulatory region of a gene encoding folate-binding

expression. Keuin E. Brigle, Eric H. Westin, Micah T. Hough- folate selection. Association with increased protein

ton, and I. Dauid Goldman

22256 Bidirectional mechanism of plasma membrane trans- port of reduced glutathione in intact rat hepatocytes and membrane vesicles. Carmen Garcia-Ruiz, Jose Carlos Fernandez-Checa, and Neil Kaplowitz

22356 Enzymatic transfer of a preassembled trisaccharide antigen to cell surfaces using a fucosyltransferase. Geeta Sriuastaua, Kanwal J . Kaur, Ole Hindsgaul, and Monica M . Palcic

22265 Polymerization of pNcollagen I and copolymerization of pNcollagen I with collagen I. A kinetic, thermody- namic, and morphologic study. Anne M. Romanic, Eijiro Adachi, Yoshio Hojima, Jurgen Engel, and Darwin J. Prockop

22272 Nucleobase transporter-mediated permeation of 2',3'- dideoxyguanosine in human erythrocytes and human

R. P. Paterson, Dauid L. J. Tyrrell, Carol E. Cass, Jose! T-lymphoblastoid CCRF-CEM cells. Wendy P. Gati, Alan

Morauek, and Morris J . Robins

22277 Stopped-flow kinetic study of vitamin E regeneration

of ubiquinone, vitamin K, and tocopherolquinone) in reaction with biological hydroquinones (reduced forms

solution. Kazuo Mukai, Shingo Itoh, and Hitoshi Morimoto

22282 Rat liver dipeptidylpeptidase IV contains competing apical and basolateral targeting information. Ora A. Weisz, Carolyn E. Machamer, and Ann L. Hubbard

22362 Multiple forms of the 20 S multicatalytic and the 26 S ubiquitin/ATP-dependent proteases from rabbit retic-

Rechsteiner ulocyte lysate. Laura Hoffman, Greg Pratt, and Martin

22369 Purification of an 11 S regulator of the multicatalytic protease. Wolfgang Dubiel, Greg Pratt, Katherine Ferrell, and Martin Rechsteiner

22378 Phosphorylation of Na,K-ATPase a-subunits in micro- somes and in homogenates of Xenopus oocytes resulting from the stimulation of protein kinase A and protein

Pralong, and K. Geering kinase C. A. V. Chibalin, L. A. Vasilets, H. Hennekes, D.

22385 A T-cell enhancer cooperates with NF-KB to yield cy-

endothelial cells. Rob Hooft van HuGsduGnen, James Whe- tokine induction of E-selectin gene transcription in

Schenk, and John F. DeLamarter lan, Rosanna Pescini, Michael Becker-And+, Anne-Marie

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22506

yguanosine adduct positioned in the (CPG)~ hot-spot of Site-specific frameshift mutagenesis by a propanodeox-

Salmonella typhimurium hisD3052 carried on an M13

Marnett vector. Mounir Benamira, Udai Singh, and Lawrence J .

sorting of PC2 in the islets of Langerhans. Paul C. Guest, The post-translational processing and intracellular

Susan D. Arden, Deborah L. Bennett, Anne Clnrk, Nicholos G. Rutherford, and John C. Hutton

Molecular cloning of AMP deaminase isoform L. Se- quence and bacterial expression of human AMPD2 cDNA. Mary T . Bausch-Jurken, Donna K. Mahnke-Zizelmn, Takayuki Morisaki, and Richard L. Sabina

Biochemical pharmacology of (+)- and (-)-2',3'-di- deoxy-3'-thiacytidine as anti-hepatitis B virus agents. Chien-Neng Chang, Violetta Skalski, James Hua Zhou, and Yung-chi Cheng

Enzymatic analysis of oligonucleotides containing cy- clobutane pyrimidine photodimers with a cleaved in-

colm C. Paterson tradimer phosphodiester linkage. Michel Liuzzi and Mal-

N-Glycosylation is required for human CD2 imrnu- noadhesion functions. Michael A. Recny, Michael A . Luther, Maria H. Knoppers, Edith A. Neidhardt, Sanjay S. Khandekar, Michael F. Concino, Patricia A. Schimke, Marilyn A. Francis, Ulcich Moebius, Bruce B. Reinhold, Vernon N. Reinhold, and Elks L. Reinherz

Differential translation of the Na,K-ATPase subunit

Edward J . Benz, Jr. mRNAs. Prasad Devarajan, Maureen Gilmore-Hebert, and

In vitro catalysis of oxidative folding of disulfide- bonded proteins by the Escherichia coli dsbA (ppfA) gene product. Yoshinori Akiyama, Shigeki Kamitani, Noriko Kusukawa, and Koreaki Ito

A macrophage Fc receptor for IgG is also a receptor for oxidized low density lipoprotein. Lawrence W. Stanton, R. Tyler White, Carmen M. Bryant, Andrew A. Protter, and Gerda Endemann

Isolation, cDNA cloning, and characterization of an 18-

from Limulus polyphemus. Nobutaka Fujii, Conceicdo A. kDa hemagglutinin and amebocyte aggregation factor

Barbehenn, Paulo H. Nunes, and Nga Yen Nguyen S. A. Minetti, Hira L. Nakhasi, Shun-Wen Chen, Elizabeth

CREB bind to AP-1 sites and inhibit activation by Jun. Transcriptional cross-talk: nuclear factors CREM and

Denis Masquilier and Paolo Sassone-Corsi

Human osteoblast-derived insulin-like growth factor (IGF) binding protein-5 stimulates osteoblast mitogen- esis and potentiates IGF action. Dennis L. Andress and Roger S. Birnbaum

Isolation and characterization of COX22, the nuclear gene for a previously unrecognized subunit of Saccha- romyces cerevisiae cytochrome c oxidase. Arthur E. P. LaMarche, Marina I. Abate, Samuel H. P. Chan, and Bernard L. Trumpower

Purification of yeast cytochrome c oxidase with a sub- unit composition resembling the mammalian enzyme. Jan- Willem Taanman and Roderick A. Capaldi

Mass spectrometric analysis of the HMGY protein from Lewis lung carcinoma. Identification of phosphoryla- tion sites. Pasquale Ferranti, Antonio Malorni, Gennaro Mar-

and Vincenzo Giancotti ino, Pier0 Pucci, Graham H. Goodwin, Guidalberto Manfioletti,

Activation of protein kinase C accelerates internaliza- tion of transferrin receptor but not of major histocom- patibility complex Class I, independent of their phos- phorylation status. Thomas Eichholtz, Paula Vossebeld, Merian uan Ouerveld, and Hidde Ploegh

Initiation of DNA replication in ColEl plasmids con-

Martin-Parras, Pablo Hernandez, Maria L. Martinez-Robles, taining multiple potential origins of replication. Luis

and Jorge B. Schvartzman

Tumor necrosis factor a and interferon y synergisti- cally induce interleukin 8 production in a human gas- tric cancer cell line through acting concurrently on AP- 1 and NF-kB-like binding sites of the interleukin 8 gene. Kazuo Yasumoto, Shu-ichi Okamoto, Naofumi Mukalda, Seishi Murakami, Masayoshi Mai, and Kouji Matsushima

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Characterization of the Escherichia coli uracil-DNA glycosylase-inhibitor protein complex. Samuel E. Ben- nett and Dale W. Mosbaugh

An amino acid substitution (G~Y' '~ + Glu) in the colla- gen al(I1) chain produces hypochondrogenesis. Ray- mond Bogaert, George E. Tiller, Mary Ann Weis, Helen E. Gruber, David L. Rimoin, Daniel H. Cohn, and David R. Eyre

Activation of Ca2+/calmodulin-dependent protein ki- nase I1 and protein kinase C by glutamate in cultured rat hippocampal neurons. Kohji Fukunaga, Thomas R. Sod- erling, and Eishichi Miyamoto

Identification of a novel type of processing sites in the precursor for the sea anemone neuropeptide antho-

elegantissima. Cornelia Schmutzler, Dorothea Darmer, Dag- RFamide (<Glu-Gly-Arg-Phe-NH2) from Anthopleura

mar Dkkhoff, and Cornelis J . P. Grimmelikhuijzen

Molecular cloning and characterization of the genes encoding the two subunits of Drosophila melanogaater calcineurin. Danilo Guerini, Craig Montell, and Claude B. Klee

Replacement of intracellular C-terminal domain of GLUT1 glucose transporter with that of GLUT2 in- creases Vmax and Km of transport activity. Hideki Kata- giri, Tomoichiro Asano, Hisamitsu Ishihara, Katsunori Tsu- kuda, Jiann-Liang Lin, Kouichi Inukai, Masatoshi Kikuchi, Yoshio Yazaki, and Yoshitomo Oka

The polyphosphate kinase gene of Escherichia coli. Isolation and sequence of the ppk gene and membrane location of the protein. Masahiro Akiyama, Elliott Crooke, and Arthur Kornberg

Bending of the Saccharomyces cerevisiae 5s rRNA

Braun, George A. Kassauetis, and E. Peter Geiduschek gene in transcription factor complexes. Burkhard R.

Proline-directed phosphorylation of human Tau pro- tein. Richard Vulliet, s. Mitchell Halloran, Ruedi K. Braun, Alan J. Smith, and Gloria Lee

Insulin treatment stimulates the tyrosine phosphoryl-

nositol3-kinase in vivo. Hideki Hayashi, Seiku Kamohara, ation of the a-type 85-kDa subunit of phosphatidyli-

Yasuhiko Nishioka, Fumihiko Kanai, Noriaki Miyake, Yasu- hisa Fukui, Futoshi Shibasaki, Tadaomi Takenawa, and You- suke Ebina

The chicken a l ( X 1 ) collagen gene is widely expressed

and William B. Upholt in embryonic tissues. Hyun-Duck Nah, Meyer Barembaum,

Functional domains of aromatase cytochrome P450 in- ferred from comparative analyses of amino acid se- quences and substantiated by site-directed mutagenesis experiments. Shiuan Chen and Dujin Zhou

Polar glycosphingolipids in annelida. A novel series of glycosphingolipids containing choline phosphate from the earthworm, Peeretima hilgendorfi. Mutsumi Suglta, Hiroshi Fujii, Fuyuhzko Inagaki, Minoru Suzukl, Chieko Hay- ata, and Taro Hori

Distinct steps in the penetration of adenylate cyclase toxin of Bordetella pertussis into sheep erythrocytes. Translocation of the toxin across the membrane. Arle Rogel and Emanuel Hanski

The effects of calcium site occupancy and reagent

heterobifunctional aryl azides. Mapping interaction do- length on reactivity of calmodulin lysyl residues with

mains with specific calmodulin photoprobe derivatives. Lori D. Dwyer, Peter J . Crocker, Dauid S. Watt, and Thomas C. Vanaman

A retinoic acid-inducible mRNA from human erythro- leukemia cells encodes a novel tissue transglutaminase homologue. Bassam M. Fraij, Paul J . Birckhichler, Manford K. Patterson, Jr., Kyung N. Lee, and Robert A. Gonzales

N-linked oligosaccharides of murine major histocom- patibility complex class I1 molecule. Role in antigenic peptide binding, T cell recognition, and clonal nonres- ponsiveness. Bishwajit Nag, David Passmore, Teresa Ken- drick, Hansha Bhayani, and Somesh D. Sharma

Studies of the sites of intracellular degradation of apo- lipoprotein B in Hep G2 cells. Seiichi Furukawa, Nobuhiro Sakata, Henry N. Ginsherg, and Joseph L. Dixon

vii

22639 Cleavage specificity on synthetic peptide substrates of

gruber, Horst Ahorn, Andreas Zophel, Ingrid Maurer-Fogy, human rhinovirus 2 proteinase 2A. Wolfgang Sommer-

Friederike Fessl, Gerd Schnorrenberg, Hans-Dieter Liebig, Die- ter Blaas, Ernst Kuechler, and Tim Skern

22645 Crystallographic and biochemical studies of the (inac- tive) Lys-49 phospholipase Az from the venom of Ag- kistridon piscivorus piscivorus. David L. Scott, Anirud- dha Achari, Juan C. Vidal, and Paul B. S i g h

22658 A simple, rapid method for purification of r-subunit, coupling factor 6, subunit d, and subunit e from rat liver H+-ATP synthase and determination of the com- plete amino acid sequence of c-subunit. Tomihiko Higuti, Yutaka Yoshihara, Kayo Kuroiwa, Yoshihiro Kawamura, Hi- roko Toda, and Fumio Sakiyama

22662 Expression and function of IRS-1 in insulin signal transmission. Xiao Jian Sun, Montserrat Mirulpeix, Martin G. Myers, Jr., Erin M. Glasheen, Jonathan M. Backer, C. Ronald Kahn, and Morris F. White

22673 Structural characterization of free glycolipids which are potential precursors for glycophosphatidylinositol anchors in mouse thymoma cell lines. Alessandro Puoti and Andreas Conzelmann

22681 Glutamate dehydrogenase from the hyperthermophile Pyrococcus furiosus. Thermal denaturation and acti-

Jae-Bum Park, Michael W. 8’. vation. Horst Klump, Jocel ne Di Ruggiero, Martin Kessel,

Adams, and Frank T. Robb

22686 Is0 renoid requirements for intracellular transport anfprocessing of murine leukemia virus envelope pro- tein. Jean H. Ouermeyer and William A. Maltese

ADDITIONS AND CORRECTIONS 22693 rabl5, a novel low molecular weight GTP-binding pro-

tein specifically expressed in rat brain. Vol. 267 (1992)

Scheller 5768-5775. Llsa A. Elfermk, Kaijiro Anzat, and Richard H.

ulator of fatty acid metabolism in Escherichia coli. V S 267 (1992) 8685-8691. Concetta C. DIRUSSO, Tamra L. Helmert, and Amy K. Metzger

22694 The ene for stinging nettle lectin (Urtica dioica agglu- tinin? encodes both a lectin and a chitinase. Vol. 267 (1992) 11085-11091. David R. Lerner and Natasha V. Raikhel

22694 Cloning and expression of a cDNA encoding human endothelium-derlved relaxing factor/nltric oxide syn-

Akito Shimouchi, Thomas Quertermous, Donald B. Bloch, and thase. Vol. 267 (1992) 14519-14522. StefanP. Janssens,

Kenneth D. Bloch

22693 Characterization of FadR, a global transcriptional re

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Vol. 267, No. 31 The Journal of Biological Chemistry November 5, 1992

CONTENTS Arranged by Subject Categories

21987

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22673

-21995

022010

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MINIREVIEW Transcriptional regulation of heat shock genes. A par- adigm for inducible genomic responses. Richard I. Mori- moto, Kevin D. Sarge, and Klara Abrauaya

CARBOHYDRATES, LIPIDS, AND OTHER NATURAL PRODUCTS

Stopped-flow kinetic study of vitamin E regeneration reaction with biological hydroquinones (reduced forms of ubiquinone, vitamin K, and tocopherolquinone) in solution. Kazuo Mukai, Shingo Itoh, and Hitoshi Morimoto

Enzymatic transfer of a preassembled trisaccharide antigen to cell surfaces using a fucosyltransferase. Geeta Sriuastava, Kanwal J . Kaur, Ole Hindsgaul, and Monica M. Palcic

Polar glycosphingolipids in annelida. A novel series of

the earthworm, Pheretima hilgendorfi. Mutsumi Sugita, glycosphingolipids containing choline phosphate from

Hiroshi Fujii, Fuyuhiko Inagaki, Minoru Suzuki, Chieko Hay- ata, and Taro Hori

N-linked oligosaccharides of murine major histocom- patibility complex class I1 molecule. Role in antigenic peptide binding, T cell recognition, and clonal nonres- ponsiveness. Bishwajit Nag, David Passmore, Teresa Ken- drick, Hansha Bhayani, and Somesh D. Sharma

Structural characterization of free glycolipids which are potential precursors for glycophosphatidylinositol anchors in mouse thymoma cell lines. Alessandro Puoti and Andreas Conzelmann

CELL BIOLOGY AND METABOLISM

type IIIb membrane protein following introduction of Enhancement of membrane insertion and function in a

a cleavable signal peptide. Xiao-Ming Guan, Tong Sun Kobilka, and Brian K. Kobilka

Ligand-dependent synergy of thyroid hormone and ret- inoid X receptors. Evan D. Rosen, Amy L. O’Donnell, and Ronald J . Koenig

Down-regulation of interleukin 6 receptors of mouse myelomonocytic leukemic cells by leukemia inhibitory factor. Masahiro Yamaguchi, Masahiro Michishita, Kazunori Hirayoshi, Kiyoshi Yasukawa, Minoru Okuma, and Kazuhiro Nagata

Parallel control of hepatic proteolysis by phenylalanine and phenylpyruvate through independent inhibitory sites at the plasma membrane. Motoni Kadowaki, A. Reeta Poso, and Glenn E. Mortimore

Control of hepatic proteolysis by leucine and isovaleryl- L-carnitine through a common locus. Evidence for a possible mechanism of recognition at the plasma mem- brane. Giouanni Miotto, Rina Venerando, Kamal K. Khurana, Noris Siliprandi, and Glenn E. Mortimore

The lymphoma transmembrane glycoprotein GP85

which regulates GP85 (CD44)-ankyrin interaction. (CD44) is a novel guanine nucleotide-binding protein

Vinata B. Lokeshwar and Lilly Y. W. Bourguignon

The regulation of the human tumor necrosis factor 01

promoter region in macrophage, T cell, and B cell lines. Kristina L. Rhoades, Sidney H. Golub, and James S. Economou

Alternative exon usage and processing of the major histocompatibility complex-encoded proteasome sub- units. Klaus Friih, Young Yang, Daniele Arnold, James Cham- bers, Lin Wu, James B. Waters, Thomas Spies, and Per A. Peterson

On the mechanisms of the formation of L-alloisoleucine and the 2-hydroxy-3-methylvaleric acid stereoisomers from L-isoleucine in maple syrup urine disease patients

Reimer and in normal humans. Orval A. Mamer and Mark L. J.

22156 Basic fibroblast growth factor is internalized through both receptor-mediated and heparan sulfate-mediated mechanisms. Monireh Roghani and David Moscatelli

22171 Insulin stimulation of phosphatidylinositol 3-kinase ac- tivity and association with insulin receptor substrate 1 in liver and muscle of the intact rat. Franco Folli, Mario J. A. Sacld, Jonathan M. Backer, and C. Ronald Kahn

22178 Selective inhibition of proliferation in v-abl- and bcr- abl-transformed cells by a nucleoside analog. Liuia Cioe, Sunil Mukhopadhyay, and Giouanni Rouera

22183

22190

22211

22249

22282

22316

22336

22340

22378

Reversal of the desensitized state of pig ovarian follic- ular human choriogonadotropin-sensitive adenylylcy- clase by guanosine 5’-0-(24hiodiphosphate). Richard C. Ekstrom, Ellen M. Carney, Marilyn L. G. Lamm, and Mary Hunzicker-Dunn

Interleukin-1-inducible genes in endothelial cells. Cloning of a new gene related to C-reactive protein and serum amyloid P component. Ferruccio Breuiario, Elisa- betta M. d’Aniello, Josee Golay, Giuseppe Peri, Barbara Bot-

entina Predazzi, Mariano Rocchi, Giuliano Della Valle, Elisa- tazzi, Amos Bairoch, Salvatore Saccone, Rosalia Marzella, Val-

betta Dejana, Alberto Mantouani, and Martino Introna

Characterization of a gain of function mutation of in-

Bajt, Joseph C. Loftus, Meinrad P. Gawaz, and Mark H. tegrin aIIb& (platelet glycoprotein IIb-IIIa). Mary Lynn

Ginsberg

Agonist-induced phosphorylation and desensitization of human m2 muscarinic cholinergic receptors in Sf9 insect cells. Ricardo M. Richardson and M. Marlene Hosey

Rat liver dipeptidylpeptidase IV contains competing apical and basolateral targeting information. Ora A. Weisz, Carolyn E. Machamer, and Ann L. Hubbard

Kinetics of Ca2+ release and contraction induced by photolysis of caged D-myo-inositol 1,4,5-trisphosphate in smooth muscle. The effects of heparin, procaine, and

David R. Trentham, Toshio Kitazawa, and Andrew P. Somlyo adenine nucleotides. Auril V. Somlyo, Keisuke Horiuti,

The CCAATIenhancer-binding protein trans-activates the human cholesteryl ester transfer protein gene pro-

Laurel Mendelsohn, and Alan R. Tall moter. Luis B. Agellon, Peiquan Zhang, Xian Cheng Jiang,

Purification and characterization of inositol-1,3,4- trisphosphate 5/6-kinase from rat liver using an inosi- tol hexakisphosphate affinity column. Munir Abdullah, Philip J . Hughes, Andrew Crawton, Roy Gigg, T. Desai, James F. Marecek, Glenn D. Prestwich, and Stephen B. Shears

Phosphorylation of Na,K-ATPase a-subunits in micro- somes and in homogenates of Xenopus oocytes resulting from the stimulation of protein kinase A and protein

Pralong, and K. Geering kinase C. A. V. Chibalin, L. A. Vasilets, H. Hennekes, D.

22414 Biochemical pharmacology of (+)- and (-)-2’,3’-di- deoxy-3”thiacytidine as anti-hepatitis B virus agents. Chien-Neng Chang, Violetta Skalski, James Hua Zhou, and Yung-chi Cheng

22440 I n uitro catalysis of oxidative folding of disulfide- bonded proteins by the Escherichia coli dsbA (ppfA) gene product. Yoshinori Akiyama, Shigeki Kamitani, Noriko Kusukawa, and Koreaki Ito

22446 A macrophage Fc receptor for IgG is also a receptor for oxidized low density lipoprotein. Lawrence W. Stanton, R. Tyler White, Carmen M. Bryant, Andrew A. Protter, and Gerda Endemann

22467 Human osteoblast-derived insulin-like growth factor

esis and potentiates IGF action. Dennis L. Andress and (IGF) binding protein-5 stimulates osteoblast mitogen-

Roger S. Birnbaum

Indicates a Communication

VI11 ...

ix

22490

22527

22550

22556

22575

22599

22630

22662

22686

22694

022003

'22018

22048

22095

22108

22217

22237

22298

Activation of protein kinase C accelerates internaliza-

patibility complex Class I, independent of their phos- tion of transferrin receptor but not of major histocom-

phorylation status. Thomas Eichholtz, Paula Vossebeld, Merian van Overveld, and Hidde Ploegh

Activation of Ca'+/calmodulin-dependent protein ki- nase I1 and protein kinase C by glutamate in cultured

erling, and Eishichi Miyamato ra t hippocampal neurons. Kohji Fukunaga, Thomas R. Sod-

Replacement of intracellular C-terminal domain of GLUT1 glucose transporter with that of GLUT2 in-

giri, Tomoichiro Asano, Hisamitsu Ishihara, Katsunori Tsu- creases Vmax and K,,, of transport activity. Hideki Kata-

kudu, Jiann-Liang Lin, Kouichi Inukai, Masatoshi Kikuchi, Yoshio Yazaki, and Yoshitomo Oka

Isolation and sequence of the ppk gene and membrane The polyphosphate kinase gene of Escherichia coli.

location of the protein. Masahiro Akiyama, Elliott Crook , and Arthur Kornberg

Insulin treatment stimulates the tyrosine phosphoryl- ation of the a-type 85-kDa subunit of phosphatidyli- nositol3-kinase in vivo. Hideki Hayashi, Seika Kamohara,

hisa Fukui, Futoshi Shibasaki, Tadaomi Takenawa, and You- Yasuhiko Nishioka, Fumihiko Kanai, Noriaki Miyake, Yasu-

suke Ebina

Distinct steps in the penetration of adenylate cyclase toxin of Bordetella pertussis into sheep erythrocytes. Translocation of the toxin across the membrane. Arie Rogel and Emanuel Hanski

Studies of the sites of intracellular degradation of apo- lipoprotein B in Hep G2 cells. Seiichi Furukawa, Nobuhiro Sakata, Henry N . Ginsberg, and Joseph L. Dixon

Expression and function of IRS-1 in insulin signal transmission. Xiao Jian Sun, Montserrat Miralpeix, Martin G. Myers, Jr., Erin M. Glasheen, Jonathan M. Backer, C. Ronald Kahn, and Morris F. White

Isoprenoid requirements for intracellular transport and processing of murine leukemia virus envelope pro- tein. Jean H. Overmeyer and William A. Maltese

tinin) encodes both a lectin and a chitinase. Vol. 267 The gene for stinging nettle lectin (Urtica dioica agglu-

(1992) 11085-11091. David R. Lerner and Natasha V. Raikhel

ENZYMOLOGY Purification of 2,3-oxidosqualene cyclase from rat liver. William R. Moore and Gerald L. Schatzman

Enhanced GTPase activity of transducin when bound to cGMP phosphodiesterase in bovine retinal rods. Frederique Pages, Philippe Deterre, and Claude Pfister

poxygenase is accompanied by retention of activity and Reversible membrane association of neutrophil 5-li-

Maclouf, Robert C. Murphy, and Peter M. Henson a change in substrate specificity. Elizabeth Hill, Jacques

of insulin receptor kinase. Lawrence S. Argetsinger and The reversible and irreversible autophosphorylations

Jules A. Shafer

lus licheniformis. In-Cheol Kim, Jae-Ho Cha, Jung-Ryul Catalytic properties of the cloned amylase from Bacil-

Kim, So-Young Jang, Byung-Cheol Sea, Tae-Kyou Cheong, Due Si1 Lee, Yang Do C h i , and Kwan-Hwa Park

Selenomethionyl dihydrofolate reductase from Esche- richia coli. Comparative biochemistry and ""Se nuclear magnetic resonance spectroscopy. Jeffrey 0. Boles, W. H.

Odom Tolleson, Jeanne C. Schmidt, R. Bruce Dunlap, and Jerome D.

Identification of the essential histidine residue at the active site of Escherichia coli dehydroquinase. Ranjit K. Deka, Colin Kleanthous, and John R. Coggins

Identification of a glycine-rich sequence as an NAD(P)H-binding site and Tyrosine 128 as a dicu- marol-blndlng site in rat liver NAD(P)H:quinone oxi- doreductase by site-directed mutagenesis. Qiang Ma, Kunyuan Cui, Fang Xiao, Anthony Y. H. Lu, and Chung S. Yang

22362

22369

22421

22512

22587

22639

-22007

22043

22079

22087

22163

22243

22256

22272

22323

22328

22473

22481

22658

Multiple forms of the 20 S multicatalytic and the 26 S ubiquitin/ATP-dependent proteases from rabbit retic- ulocyte lysate. Laura Hoffman, Greg Pratt, and Martin Rechsteiner

Purification of an 11 S regulator of the multicatalytic protease. Wolfgang Dubiel, Greg Pratt, Katherine Ferrell, and Martin Rechsteiner

clobutane pyrimidine photodimers with a cleaved in- Enzymatic analysis of oligonucleotides containing cy-

tradimer phosphodiester linkage. Michel Liuzzi and Mal- colm C. Paterson

Characterization of the Escherichia coli uracil-DNA glycosylase-inhibitor protein complex. Samuel E. Ben- nett and Dale W. Mosbaugh

Functional domains of aromatase cytochrome P450 in- ferred from comparative analyses of amino acid se- quences and substantiated by site-directed mutagenesis experiments. Shiuan Chen and Dujin Zhou

Cleavage specificity on synthetic peptide substrates of

gruber, Horst Ahorn, Andreas Zophel, Ingrid Maurer-Fogy, human rhinovirus 2 proteinase 2A. Wolfgang Sommer-

Friederike Fessl, Gerd Schnorrenberg, Ham-Dieter Liebig, Die- ter Blaas, Ernst Kuechler, and Tim Skern

MEMBRANES AND BIOENERGETICS Electrogenic uptake of y-aminobutyric acid by a cloned transporter expressed in Xenopus oocytes. Michael P.

Amara Kauanaugh, Jeffrey L. Arriza, R. Alan North, and Susan G.

The stereospecific interaction between chlorophylls and chlorophyllase. Possible implication for chloro- phyll biosynthesis and degradation. Leszek Fiedor, Varda Rosenbach-Belkin, and Avigdor Scherz

L-Threonine transport in pig jejunal brush border membrane vesicles. Functional characterization of the unique system B in the intestinal epithelium. David D. Maenz and John F. Patience

Lactose transport system of Streptococcus thermophi- lus. Functional reconstitution of the protein and char- acterization of the kinetic mechanism of transport. Catherine Foucaud and Bert Poolman

Glycophorin A facilitates the expression of human band 3-mediated anion transport in Xenopus oocytes. Jona- than D. Groves and Michael J. A. Tanner

Reversible, nonionic, and pH-dependent association of cytochrome c with cardiolipin-phosphatidylcholine li- posomes. Marjatta Rytomaa, Pekka Mustonen, and Paavo K. J . Kinnunen

Bidirectional mechanism of plasma membrane trans- port of reduced glutathione in intact ra t hepatocytes

Ferncindez-Checa, and Neil Kaplowitz and membrane vesicles. Carmen Garcia-Ruiz, Jose Carlos

Nucleobase transporter-mediated permeation of 2',3'- dideoxyguanosine in human erythrocytes and human

R. P. Paterson, David L. J. Tyrrell, Carol E. Cass, Josef T-lymphoblastoid CCRF-CEM cells. Wendy P. Gati, Alan

Morauek, and Morris J . Robins

Phosphate transport by capillaries of the blood-brain barrier. Lise Dallaire and Richard Bdliveau

Glutaraldehyde cross-links Lys-492 and Arg-678 at the active site of sarcoplasmic reticulum CaZ+-ATPase. David B. McIntosh

Isolation and characterization of COX12, the nuclear gene for a previously unrecognized subunit of Saccha- romyces cereuisiue cytochrome c oxidase. Arthur E. P. LaMarche, Marina I. Abate, Samuel H. P. Chan, and Bernard L. Trumpower

Purification of yeast cytochrome c oxidase with a sub-

Jan- Willem Taanman and Roderick A. Capaldi unit composition resembling the mammalian enzyme.

A simple, rapid method for purification of c-subunit, coupling factor 6, subunit d, and subunit e from rat

plete amino acid sequence of c-subunit. Tamihiko Higuti, liver H+-ATP synthase and determination of the com-

Yutaka Yoshihara, Kayo Kuroiwa, Yoshihiro Kawamura, Hi- roko Toda, and Fumio Sakiyama

Indicates a Communication

X

NUCLEIC ACIDS, PROTEIN SYNTHESIS, AND MOLECULAR GENETICS

021999 The Wilms’ tumor gene product, WT1, represses tran- scription of the platelet-derived growth factor A-chain gene. Zhao Y i Wang, Stephen L. Madden, Thomas F. Deuel, and Frank J . Rauscher 111

22265 Polymerization of pNcollagen I and copolymerization of pNcollagen I with collagen I. A kinetic, thermody-

Adachi, Yoshio Hojima, Jurgen Engel, and Darwin J. Prockop namlc, and morphologic study. Anne M. Romanic, Eijiro

22351 Insertion of an intracisternal A particle within the 5’- regulatory region of a gene encoding folate-binding protein in L1210 leukemia cells in response to low folate selection. Association with increased protein expression. Kevin E. Brigle, Eric H. Westin, Micah T. Hough- ton, and I. David Goldman

22385 A T-cell enhancer cooperates with NF-KB to yield cy- tokine induction of E-selectin gene transcription in endothelial cells. Rob Hooft van Huijsduijnen, James Whe-

Schenk, and John F. DeLamarter lan, Rosanna Pescini, Michael Becker-Andri, Anne-Marie

22392 Site-specific frameshift mutagenesis by a propanodeox- yguanosine adduct positioned in the (CPG)~ hot-spot of Salmonella typhimurium hisD3052 carried on an M13 vector. Mounir Benamira, Udai Singh, and Lawrence J . Marnett

22401 The post-translational processing and intracellular sorting of PC2 in the islets of Langerhans. Paul C. Guest, Susan D. Arden, Deborah L. Bennett, Anne Clark, Nieholos G. Rutherford, and John C. Hutton

22407 Molecular cloning of AMP deaminase isoform L. Se- quence and bacterial expression of human AMPD2 cDNA. Mary T. Bausch-Jurken, Donna K. Mahnke-Zizelman, Takayuki Morisaki, and Richard L. Sabina

22435 Differential translation of the Na,K-ATPase subunit mRNAs. Prasad Deuarajan, Maureen Gilmore-Hebert, and Edward J . Benz, Jr.

22460 Transcriptional cross-talk: nuclear factors CREM and CREB bind to AP-1 sites and inhibit activation by Jun. Denis Masquilier and Paolo Sassone-Corsi

22496 Initiation of DNA replication in ColEl plasmids con- taining multiple potential origins of replication. Luis Martin-Parras, Pablo Hernandez, Maria L. Martinez-Robles, and Jorge B. Schvartzman

22506 Tumor necrosis factor a and interferon y synergisti- cally induce interleukin 8 production in a human gas- tric cancer cell line through acting concurrently on AP-

gene. Kazuo Yasumoto, Shu-rchi Okamoto, Naofumi Mukaida, 1 and NF-kB-like binding sites of the interleukin 8

Seishi Murakami, Masayoshi Mai, and Kouji Matsushima

22522 An amino acid substitution (Glysa3 4 Glu) in the colla- gen al(I1) chain produces hypochondrogenesis. Ray-

Gruber, David L. Rimoin, Daniel H. Cohn, and David R. Eyre mond Bogaert, George E. Tiller, Mary Ann Weis, Helen E.

22534 Identification of a novel type of processing sites in the precursor for the sea anemone neuropeptide antho- RFamide (cGlu-Gly-Arg-Phe-NHz) from Anthopleura elegantissima. Cornelia Schmutzler, Dorothea Darmer, Dag- mar Diekhoff, and Cornelis J . P. Grimmelikhuijzen

22542 Molecular cloning and characterization of the genes

calcineurin. Danilo Guerini, Craig Montell, and Claude B. encoding the two subunits of Drosophila melanogaster

Klee

22562 Bending of the Saccharomyces cerevisiae 5s rRNA gene in transcription factor complexes. Burkhard R. Braun, George A. Kassavetis, and E. Peter Geiduschek

22581 The chicken al(X1) collagen gene is widely expressed in embryonic tissues. Hyun-Duck Nah, Meyer Barembaum, and William B. Upholt

22616 A retinoic acid-inducible mRNA from human erythro- leukemia cells encodes a novel tissue transglutaminase

K. Patterson, Jr., Kyung N. Lee, and Robert A. Gonzales homologue. Bassam M. Fraij, Paul J . Birckbichler, Manford

22693

22693

22694

021991

022014

22022

22054

22115

22122

22148

22198

22206

22224

22230

22289

22305

22310

rabl5, a novel low molecular weight GTP-binding pro- tein specifically expressed in rat brain. Vol. 267 (1992) 5768-5775. Lisa A. Elferink, Kaijiro Anzai, and Richard H. Scheller

Characterization of FadR, a global transcriptional reg- ulator of fatty acid metabolism in Escherichia coli. Vol. 267 (1992) 8685-8691. Concetta C. DiRusso, Tamra L. Heimert, and Amy K. Metzger

Cloning and expression of a cDNA encoding human endothelium-derived relaxing factorlnitric oxide syn- thase. Vol. 267 (1992) 14519-14522. StefanP. Janssens, Akito Shimouchi, Thomas Quertermous, Donald B. Bloch, and Kenneth D. Bloch

PROTEIN CHEMISTRY AND STRUCTURE Identification of intramolecular interactions in adre- nergic receptors. Sankuratri Suryanarayana, Mark uon Zas- trow, and Brian K. Kobilka

Thermostabilization of Escherichia coli ribonuclease HI by replacing left-handed helical Lyssa with Gly or

Nakamura Asn. Shigenobu Kimura, Shigenori Kanaya, and Haruki

bination in myoglobin. An experimental and molecular Distal pocket residues affect picosecond ligand recom-

son, Rebecca Regan, Ron Elber, John S. Olson, and Theodore dynamics study of position 29 mutants. Quentin H. Gib-

E. Carver

Identification of actin and HSP 70 as cyclosporin A binding proteins by photoaffinity labeling and fluores- cence displacement assays. Marcia L. Moss, Rick E. Palmer, Petr KuzmiE, Brian E. Dunlap, William Henzel, James L. Kofron, William S. Mellon, Catherine A. Royer, and Daniel H. Rich

Purification and partial characterization of candidate antidiuretic hormone water channel proteins of M. 55,000 and 53,000 from toad urinary bladder. H. Wil- liam Harris, Jr., Christine Hosselet, Lisa Guay- Woodford, and Mark L. Zeidel

1.9-A resolution structure of fasciculin 1, an anti-ace- tylcholinesterase toxin from green mamba snake

and Juan C. Fontecillu-Camps venom. Marie H. le Du, Pascale Marchot, Pierre E. Bougis,

Negative complementation in aspartate transcarbam- ylase. Analysis of hybrid enzyme molecules containing different arrangements of polypeptide chains from wild-type and inactive mutant catalytic subunits. Ed- ward Eisenstein, Min S. Hun, Tammy S. Woo, James M. Ritchey, Ian Gibbons, Ying R. Yang, and H. K. Schachman

The identification of a domain in Escherichia coli elon- gation factor Tu that interacts with elongation factor Ts. Yu- Wen Hwang, Mary Carter, and David L. Miller

Tissue factor residues 157-167 are required for effi- cient proteolytic activation of factor X and factor VII.

Thomas S. Edgington Wolfram Ruf, David J . Miles, Alnawaz Rehemtulln, and

The role of the COOH-terminal region of antithrombin 111. Evidence that the COOH-terminal region of the inhibitor enhances the reactivity of thrombin and fac- tor Xa with the inhibitor. Junji Nishioka and Koji Suzuki

Crystal structure disposition of thymidylic acid tetra-

and Alexander McPherson mer in complex with ribonuclease A. David L. Blrdsall

genase from two methylotrophic bacteria a t 2.6-A The three-dimensional structures of methanol dehydro-

Zhi-ping Hao, Victor L. Dauidson, Scott White, and F. Scott resolution. Zong-riang Xia, Wei-wen Dai, Jian-ping Xiong,

Mathews

Identification of xenin, a xenopsin-related peptide, in

pancreatic secretion. Gerhard E. Feurle, Gerd Hamscher, the human gastric mucosa and its effect on exocrine

Reinhard Kusiek, Helmut E. Meyer, and Jorg W. Metzger

Affinity purification and characterization of myristoy- lated alanine-rich protein kinase C substrate (MARCKS) from bovine brain. Comparison of the cytoplasmic and the membrane-bound forms. Stephane Manenti, Odile Sorokine, Aloin Van Dorsselaer, and Hisaaki Taniguchi

Indicates a Communication

xi

22346 COMP (cartilage oligomeric matrix pro.tein) is struc-

Antonsson, Karin Lcndblom, and Dick Heinegcird turally related to the thrombospondins. Ake Oldberg, Per

22428 N-Glycosylation is required for human CD2 immu- noadhesion functions. Michnel A. Recn , Michael A Luther, Maria H. Knoppers, Edith A. Neidhardt, ,$anjay S. Khndekar , Michael F. Concino, Patricia A. Schimke, Marilyn A. Francis, Ulrich Moebiw, Bruce B. Reinhold, Vernon N. Reinhold, and Ellis L. Reinherz

22452 Isolation, cDNA cloning, and characterization of an 18- kDa hemagglutinin and amebocyte aggregation factor from Limulus polyphemus. Nobutaka Fujii, Conceipio A.

Barbehenn, Paulo H. Nunes, and Nga Yen Nguyen S. A. Minetti, Hira L. Nakhasi, Shun-Wen Chen, Elizabeth

22486 Mass spectrometric analysis of the HMGY protein from

tion sites. Pasquale Ferranti, Antonio Malorni, Gennaro Mar- Lewis lung carcinoma. Identification of phosphoryla-

and Vincenzo Giancotti ino, Piero Puccc, Graham H. Goodwin, Guidalberto Manfioletti,

22570 Proline-directed phosphorylation of human Tau pro- tein. Richard Vulliet, S. Mitchell Halloran, Ruedi K. Braun, Alan J. Smith, and Gloria Lee

22606 The effects of calcium site occupancy and reagent length on reactivity of calmodulin lysyl residues with heterobifunctional aryl azides. Mapping interaction do- mains with specific calmodulin photoprobe derivatives. Lori D. Dwyer, Peter J. Crocker, David S. Watt, and Thomas C. Vunaman

22645 Crystallographic and biochemical studies of the (inac- tive) Lys-49 phospholipase Ar from the venom of Ag- kistridon piscivorus piscivorus. David L. Scott, Anirud- dha Achari, J u a n C. Vidal, and Paul B. Sigler

22681 Glutamate dehydrogenase from the hyperthermophile Pyrococcus furiosus. Thermal denaturation and acti-

Jae-Bum Park, Michael W. W. A d a m , and Frank T. Robb vation. Horst Klump, Jocelyne Di Ruggiero, Martin Kessel,

Abate, Marina I., 22473

Abravaya, Klara, 21987 Ahdullah, Munir, 22340

Achari, Aniruddha, 22645 Adachi, Eijiro, 22265 Adams, Michael W. W.,

Agellon, Luis B., 22336 Ahorn. Horst, 22639 Akiyama, Masahiro, 22556 Akiyama, Yoshinori, 22440 Amara, Susan G., 22007 Andress, Dennis L., 22467 Antonsson, Per, 22346 Anzai, Kaijiro, 22693 Arden, Susan D., 22401 Argetsinger, Lawrence S.,

Arnold, Daniele, 22131

Asano, Tomoichiro, 22550 Arriza, Jeffrey L., 22007

Backer, Jonathan M., 22171,

Bairoch, Amos, 22190 Bajt, Mary Lynn, 22211 Barbehenn, Elizabeth, 22452 Baremhaum, Meyer, 22581 Bausch-Jurken, Mary T.,

Becker-Andre, Michael,

Bbliveau, Richard, 22323 Benamira, Mounir, 22392 Bennett, Deborah L., 22401 Bennett, Samuel E,, 22512 Benz, Edward J., Jr., 22435 Bhayani, Hansha, 22624 Birckbichler, Paul J., 22616 Birdsall, David L., 22230 Birnbaum, Roger S., 22467 Blaas, Dieter, 22639

Bloch, Kenneth D., 22694 Bloch, Donald B., 22694

Bogaert, Raymond, 22522 Boles, Jeffrey O., 22217

Bougis, Pierre E., 22122 Bottazzi, Barbara, 22190

Bourguignon, Lilly Y. W.,

Braun, Burkhard R., 22562 Braun, Ruedi K., 22570

Brigle. Kevin E., 22351 Breviario, Ferruccio, 22190

Bryant, Carmen M., 22446 Capaldi, Roderick A,, 22481

Carter, Mary, 22198 Carney, Ellen M., 22183

Carver, Theodore E., 22022

22681

22095

22662

22407

22385

22073

Cass, Carol E., 22272 Cha, Jae-Ho, 22108 Chambers, James, 22131 Chan, Samuel H. P., 22473 Chang, Chien-Neng, 22414

Chen, Shun-Wen, 22452 Chen, Shiuan, 22587

Cheng, Yung-chi, 22414 Cheong, Tae-Kyou, 22108 Chibalin, A. V., 22378 Choi, Yang Do, 22108 CioB, Livia, 22178 Clark, Anne, 22401 Coggins, John R., 22237 Cohn, Daniel H., 22522 Concino, Michael F., 22428 Conzelmann, Andreas, 22673 Craxton, Andrew, 22340 Crocker, Peter J., 22606 Crooke, Elliott, 22556 Cui, Kunyuan, 22298 Dai, Wei-wen, 22289 Dallaire, Lise, 22323 d'Aniello, Elisabetta M.,

Darmer, Dorothea, 22534 Davidson, Victor L., 22289 Dejana, Elisabetta, 22190 Deka, Ranjit K., 22237 DeLamarter, John F., 22385 Desai, T., 22340 Deterre, Philippe, 22018 Deuel, Thomas F., 21999 Devarajan, Prasad, 22435 Diekhoff, Dagmar, 22534 Di Ruggiero, Jocelyne, 22681 DiRusso, Concetta C., 22693

Dorsselaer, Alain Van, 22310 Dixon, Joseph L., 22630

Dubiel, Wolfgang, 22369 Dunlap, Brian E., 22054 Dunlap, R. Bruce, 22217 Dwyer, Lori D., 22606 Ebina, Yousuke, 22575 Economou, James S., 22102

Eichholtz, Thomas, 22490 Edgington, Thomas S., 22206

Eisenstein, Edward, 22148 Ekstrom, Richard C., 22183

Elferink, Lisa A,, 22693 Elber, Ron, 22022

Endemann, Gerda, 22446 Engel, Jurgen, 22265 Eyre, David R., 22522 Fernandez-Checa, J o d

Ferranti, Pasquale, 22486 Ferrell, Katherine, 22369

22190

Carlos, 22256

AUTHOR INDEX

Fessl, Friederike, 22639 Feurle, Gerhard E., 22305 Fiedor, Leszek, 22043 Folli, Franco, 22171 Fontecilla-Camps, Juan C.,

Fraij, Bassam M., 22616 Foucaud, Catherine, 22087

Francis, Marilyn A,, 22428 Friih, Klaus, 22131 Fujii, Hiroshi, 22595 Fujii, Nobutaka, 22452 Fukui, Yasuhisa, 22575 Fukunaga, Kohji, 22527 Furukawa, Seiichi, 22630

22122

Garcia-Ruiz, Carmen, 22256

Gawaz. Meinrad P.. 22211 Gati, Wendy P., 22272

Geering, K., 22378 ' ~

Giancotti, Vincenzo, 22486 Geiduschek, E. Peter, 22562

Gibbons, Ian, 22148 Gibson, Quentin H., 22022 Gigg, Roy, 22340 Gilmore-Hehert, Maureen,

Ginsberg, Henry N., 22630 Ginsberg, Mark H., 22211 Glasheen, Erin M., 22662 Golay, Josbe, 22190 Goldman, I. David, 22351 Goluh, Sidney H., 22102 Gonzales, Robert A., 22616 Goodwin, Graham H., 22486 Grimmelikhuijzen, Cornelis

Groves, Jonathan D., 22163

Guan, Xiao-Ming, 21995 Gruher, Helen E., 22522

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