big data and artificial intelligence applied to healthcare and …€¦ · data preparaon using...

Big Data and Artificial Intelligence applied to Healthcare and Biology

(BigArt-HuB)

FirstInPrIntSeminarPartnershipBuildingtowards

StrongerEngagementinInterna7onalCollabora7onGiseleLPappa,CSDepartment,UFMG

UFMG,BeloHorizonte

19-23November2018

HowPrInt/UFMGchangesthewayswecollaborate

PrInt/UFMGmobilitygoals

•  Tofosterandenhancecollabora;onwithpartneruniversi7esworldwidebymeansofjointinnova7veresearchandcapacitybuildingofhumanresources

•  ToconsolidatethetrainingandexperienceabroadofUFMGfacultymemberswithbothajuniorandaseniorprofileasvisi7ngprofessorsatpartneruniversi7es

•  TotrainPhDstudentsabroadthroughinternshipsatpartneruniversi7eswithastrongfocusoncotutelle(doublePhDdegrees)

•  Torecruitpostdoctoralfellowsandearly-careerresearcherswithexperienceabroadtoworkatUFMGwithinthePrIntthemesandprojects

•  ToaCractinterna;onallyrenownedvisi;ngprofessorswithhighlyrecognisedexperienceforshortstays(15days)atUFMG

PrInt/UFMGmobilityac;ons

OUTGOING

•  PhDmobilitygrantsforinternshipsabroad(sixtotwelvemonths)•  JuniorProfessorgrantsforvisi7ngprofessorshipsabroad(sixmonths)•  SeniorProfessorgrantsforvisi7ngprofessorshipsabroad(sixmonths)

INCOMING

•  Postdoctoralgrantsforac7vi7esatUFMG(12months,renewable)•  Early-careerresearchergrantsforac7vi7esatUFMG(12months,renewable)•  SeniorProfessorgrantsforinterna7onalvisitorsatUFMG(15days)

UFMGGraduateprogramstakingpartinBig Data and Artificial Intelligence applied to Health and Biology

•  AppliedLinguis7cs•  BiochemistryandImmunology•  Chemistry•  ClinicalandToxicologicalAnalysis•  ComputerScience•  Economics•  KnowledgeOrganiza7onandManagement

•  PhysiologyandPharmacology•  Produc7onengineering•  PublicHealth•  Rehabilita7onSciences•  Sta7s7cs•  TropicalMedicine

Partnerins;tu;onswillingtocollaboratewithUFMGinthisproject(sofar)

•  UniversityofAuckland•  UniversityofLille•  UniversityofSouthampton

Newcollabora;onswillbemostwelcome!

WhatdowemeanbyBigDataandAr;ficialIntelligenceappliedtoHealthandBiology?

Conceptualframework:


Exis7ngcompetenciesandexper7searedividedinto3groups:

•  Datacollec7on,dataunderstandingandrelatedhealth/biologyproblems

• Methods/TechniquesrelatedtotheBDAIframeworkphases

•  Evalua7onofhealthservicesandhealthpolicies




• Methods/TechniquesrelatedtotheBDAIframeworkphases•  Evalua7onofhealthservicesandhealthpolicies


Problemsareorganizedin3maingroups:


Datacollec7onandunderstandingrelatedtotheBDAIframework

1.  DataPrepara7onusingontologiesa.  Dataintegra7onb.  Dataenrichmentc.  Dataprovenance

2.  Seman7cGraphcrea7ona.  Networkofobjectsthatinstancitatedata


Examplesofdatatypesinvolvedintheseproblems:

1.  Medicalequipmentgeoloca7on2.  EQ-5D-3Lques7onnaires3.  Transcrip7onofrecordedpa7ent-healthcareproviderinterac7on4.  Administra7veandepidemiologicalrecordsfromtheBrazilianpopula7on

usingthePublicHealthSystem(SUS):RealWorldEvidences5.  Electrocardiogramrecordingandechocardiogramvideos6.  Datafromtrainingandotherneuromusculoskeletalaspectsofathletes7.  RNA,DNA,Genes,Proteins(An7bodies)8.  NuclearMagne7cResonancedata-imageandsolu7ondata9.  Thermalanalysisdataofdrugsandmedicines.


Methods/TechniquesrelatedtotheBDAIframeworkphases

1.  MachineLearninga.  Exper7seinbothclassifica7on,regression,clusteringandassocia7on

ruleminingb.  Deeplearningc.  AutomatedMachineLearning(AutoML)

2.  Textmining3.  Bayesiansta7s7cs


Methods/TechniquesrelatedtotheBDAIframeworkphases

4.Dealingwith7meseriesdata,geolocateddata,videos,highvolumesoftext,datawithmorecolumnsthanlines(microarray),amongothers.5.Op7miza7on/evalua7onofhealthtechniques/technologiestohelpthedecisionmakingprocessusingreal-worldevidences.


Evalua;onofhealthservicesandhealthpolicies:1.  Evalua7onofhealthservicesdealingwithchronickidneydisease,cancer,

mentalhealth,amongothers2.  Analysisoftheeffec7venessandexpendituresofhealthpolicies3.  Evalua7onoftechnologiesfortreatmentandhighcostmedicines4.  Evalua7onofeduca7onalinterven7onstowardspa7entself-management

andempowerment


Short,mediumandlong-termgoals:•  Developnewsta7s7cal/machinelearningmethodstodealwiththeintrinsiccharacteris7csofmedicaldata

•  Improvethecomputa7onalinfrastructuretostoreandmanipulatelargeamountsofdata

•  Developnewtechnologiesfordataacquisi7onandmanipula7on•  Beabletotakeadvantageofalargeamountofdatatoimprovepublichealth,individualhealthandtheBrazilianPublicHealthSystemingeneral

•  Developnewcollabora7onswithotherins7tu7onswithsimilarandcomplementaryexper7ses/interests

Researchissuesandques;ons

Ongoingprojectsandrelatedresearchques7ons•  ComputerScience

•  Howtochoosethebestsetofdataanalysistasksthatshouldbeperformedinagivendataset?•  DevelopAuto-MLtechniquesabletogeneratecustomizedtaskflowsfordataanaly7csinmedicine.

•  KnowledgeOrganiza;onandManagement•  Howtosystemizedataprepara7onallowingbeherreproducibility?

•  Useofseman7cannota7ontechniquesbasedonontologies

Researchissuesandques;onsOngoingprojectsandrelatedresearchques7ons

•  Produc;onengineering•  Howtoimproveplanningandopera7onaliza7onofservicesinhospitals?

•  Exploreop7miza7ontechniquesforcombinatorialproblemstobeherplanhospitalschedules.

•  Sta;s;cs•  Whatisthe7meun7ltheoccurrenceofaneventofinterest,suchasthedetec7onofadiseaseinanindividual?•  Propose(semi-)parametricmethodstotreatspecificcharacteris7csofhealthdata,includingrecurrentevents,longitudinalcovariates,amongothers.

Researchissuesandques;onsOngoingprojectsandrelatedresearchques7ons•  AppliedLinguis;cs

•  CanwefinddiscourseIndicatorsofpa7entempowermentandself-managementefficacyinchronicdiseases(diabetesandsicklecelldisease)?•  Useoftextminingtechniques

•  Rehabilita;onSciences•  Canwepredicttheoccurenceofmusculoskeletalinjuriesinathletesfrombiomechanical,physiologicalandpsychologicaldatacollectedduringthecompe77onseason?•  Regressionandpredic7vemethodstodealwith7me-seriesdata.


Ongoingprojectsandrelatedresearchques7ons

•  BiochemistryandImmunology•  Whatarethean7bodiesac7vatedbytheyellowfevervaccine?Cantheybeusedforyellowfevertreatment?•  Sta7s7calanalysisofthenucleo7dessequencesthatcodifythean7bodies.

•  Chemistry•  Whatarethekine7cmechanismsforthermaldecomposi7onofmedicines,drugsandcarbonnanotubes?•  Methodsfornon-linearanalysisofexperimentalresults

Molecularanalysisofan;bodieselicitedaYerYellowFevervaccina;on

BiochemistryandImmunology


Ongoingprojectsandrelatedresearchques7ons

•  PublicHealth•  Canweuseadministra7veandepidemiologicaldatatoevaluatetheeffec7venessandcostsofcancer,chronickidneydisease,hospitaliza7onofmentaldisease,coronaryarterialdisease,amongothers?•  Useintegratedadministra7veandepidemiologicaldatatoevaluatethetreatmentandmedicinesofhighcost

OngoingandProspec;veCollabora;ons

•  BostonUniversity•  CarnegieMellonUniversity•  CNRS•  GeorgeWashingtonUniversity•  NorthCarolinaStateUniversity•  UniversidadedeCoimbra•  UniversitàdegliStudidiMilano•  UniversityofBremen•  UniversityofCincinna7

•  UniversityofKent(UK)•  UniversityofMelbourne•  UniversityofPihsburgh•  UniversityofSouthampton•  UniversityofSydney•  UniversityofTexas,Aus7n•  UniversitàdiPadova•  VrijeUniversiteit(Amsterdam)

ConcludingremarksforBigDataandAr;ficialIntelligenceappliedtoHealthandBiology

•  UFMGhasdifferentexper7sesintheareaofBigDataandAr7ficialIntelligenceappliedtoHealthandBiology,mainlydividedinto3groups:•  Datacollec7on,dataunderstandingandrelatedhealth/biologyproblems•  Methods/TechniquesrelatedtotheBDAIframeworkphases•  Evalua7onofhealthservicesandhealthpolicies

•  Inthelongterm,wewanttobeabletotakeadvantageofalargeamountofdatatoimprovepublichealth,individualhealthandtheBrazilianPublicHealthSystemingeneral

•  Developnewcollabora7onswithotherins7tu7onswithsimilarandcomplementaryexper7ses

Big Data and Artificial Intelligence applied to Healthcare and Biology

(BigArt-HuB)

FirstInPrIntSeminarPartnershipBuildingtowards

StrongerEngagementinInterna7onalCollabora7onGiseleLPappa,CSDepartment,UFMG

UFMG,BeloHorizonte

19-23November2018

big data and artificial intelligence applied to healthcare and …€¦ · data preparaon using...

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