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Many congratulations to Mike Ryan David Stroud and team for their outstanding research onmitochondrial function A tour de force of cell biology and proteomics has led to a much deeperunderstanding of the role of the subunits that make up Complex I of the electron transport chain Theirresearch has the potential to help alleviate the problem of mitochondrial disease and is the culminationof many years of hard work

And congratulations to one of our undergraduate students Anoushka Lal who has successfully outshycompeted hundreds of other applicants to scoop a junior nobel prize ndash winning the oceanic regions lifeshysciences category in the Undergraduate Awards

In other news in a great example of collaborative research seven of our researchers have securedintershyfaculty funding from the inaurgural ScienceshyFBPS seed funding scheme

Best wishes John

In this issue

News | Press | Publications | Events and seminars | Funding and opportunities

For all stories in this issue of the BDI Newsletter and every past issue too visit

wwwbdishynewslettercom

Unravelling the genetic mystery behind mitochondrial disease

Mitochondrial disease robs its sufferers of energy and damages muscles and major organsAbout one Australian baby is born each week with a severe form of the disease which can oftenlead to an early death A research team headed by Professor Mike Ryan and Dr DavidStroud have identified two new genes linked to a major cause of mitochondrial disease in apaper published in Nature Their work opens the way for better and earlier genetic diagnosis ofthe disease Read more

News

Anoushka Lal a regional winner in theUndergraduate Awards

Student Anoushka Lal has been named the regional winner ofthe Life Sciences category in the international UndergraduateAwards ndash often referred to as the Junior Nobel Prizes ndash for theOceania region The Undergraduate Awards are the largestacademic awards program in the world with 5514 submissionsfrom students at 244 universities across 40 countries this yearalone Read more

Unravelling the complexities of the brain ndashone immune cell at a time

The brain is literally the last frontier for the human immunesystem ndash for the most part the brain and the immune systemremain separate Increasingly however we are learning newways in which the immune system interacts with the braincausing diseases such as multiple sclerosis A paper from theBDIrsquos Professor Paul McMenamin published in the journal Gliaprovides clues to the types of immune cells that are present andabsent in the brain Read more

Collaborating across borders to enhancediscoveries

Seven of our researchers have been successful in gaining seedfunding for establishing research collaborations with MonashsFaculty of Science These inaugural intershydisciplinary grants aredesigned to help researchers carry out highly innovative orproofshyofshyprinciple studies with an aim to garner future externalfunding Read more

Present alongside elite lineshyup atthe Metabolic Diseases meeting

The early bird and oral abstract deadlines for the MetabolicDiseases Breakthrough Discoveries in Diabetes and ObesityMeeting held in St Kilda in December is fast approaching Thereare still slots for talks up for grabs with these to be selected fromabstracts These talks will afford ECRs the opportunity to presentalongside an elite lineshyup of speakers and to an audience thatwill include editors from Nature Medicine and CellMetabolism Read more

Press

Unscratching poison ivys rash in the press

Recent research published in Nature Immunology by ProfessorJamie Rossjohn Dr Tang Yongqing and Dr Jerome LeNourshas that uncovered the molecular cause of poinson ivysitch sparked news stories in The Australian Science Dailyand Asian Scientist among others Their findings bring us a stepcloser to designing agents to block this mechanism and shedslight on other serious skin conditions such as psoriasis

Publications

Have you had a paper accepted for publication Its never too early to let the media and

communications team know at bdishynewsmonashedu

Please note only BDIshyaffiliated authors are listed with their publication below

The modular nature of the βshybarrel assembly machinery illustrated in Borrelia burgdorferi(Stubenrauch C Grinter R Lithgow T)

The role of protein dynamics in the evolution of new enzyme function(Porebski BT Buckle AM)

A communityshybased model of rapid autopsy in endshystage cancer patients(Taylor RA Papargiris MM Lawrence MG Wang H Risbridger GP)

The Cshyterminal 18 Amino Acid Region of Dengue Virus NS5 Regulates its Subcellular Localization andContains a Conserved Arginine Residue Essential for Infectious Virus Production(Jans DA)

Nucleocytoplasmic trafficking of Nipah virus W protein involves multiple discrete interactions with thenuclear import and export machinery(Audsley MD Jans DA)

The porin VDAC2 is the mitochondrial platform for Bax retrotranslocation(Nguyen TN Lazarou M)

Hepatocyte glutathione peroxidaseshy1 deficiency improves hepatic glucose metabolism and decreasessteatohepatitis in mice(Merry TL Tran M Dodd GT Wiede F Kaur S Tiganis T)

The NEAT DomainshyContaining Proteins of Clostridium perfringens Bind Heme(Choo JM Cheung JK Wisniewski JA Hiscox TJ Chakravorty A Rood JI Awad MM)

Nonshylinear effects of potassium channel blockers on endotheliumshydependent hyperpolarization(Coleman HA Tare M Parkington HC)

Events and seminars

BDI Seminars

Thursday September 22 Please note this seminar has been cancelled

BDI Special Seminar

Wednesday September 28 11ndash12pm Topic Alternative Drug Discovery in Pharma shy a snapshot ofdiversity in GSK drug discovery through collaboration Speaker Dr John Haselden Research andDevelopment GSK More information

gtgt View our calendar of future seminars

Funding and opportunities

Information from the Faculty Research Office

2016 veski inspiring women fellowships shy APPLICATIONS NOW OPEN shy deadline 27 October 2016

MPCCC Research Grant ndash APPLICATIONS NOW OPEN ndash deadline 30 November 2016

Australian Respiratory Council Harry Windsor Research Grants ndash deadline 1 November 2016

Alzheimerrsquos Australia Dementia Research Foundation shy 2016 Dementia Grants Program (Round 2)

Download the word document ndash NHMRC Standard Equipment Grants for 2016 $574690 shy CALL FOR

APPLICATIONS [UNDER EMBARGO]

Monash Warwick Alliance Seed Fund 2016 shy APPLICATIONS NOW OPEN shy deadline November 132016

Betty Laidlaw MND Research Prize (up to $250000) shy APPLICATIONS NOW OPEN shy deadline 30September 2016

Grand Challenges Grant Opportunities shy deadline October 18 2016

Other Opportunities

Monash Partners Comprehensive Cancer Consortium (MPCCC) research grant shy deadline November30

Committed to excellence in discovery research the newly established Monash BiomedicineDiscovery Institute brings together more than 120 internationallyshyrenowned research teams into

six healthshyfocussed programs Our researchers are supported by worldshyclass facilities andinfrastructure and partner with industry clinicians and researchers internationally to enhance

lives through discovery

Copyright copy 2016 Monash Biomedicine Discovery Institute All rights reserved Youre receiving thisbecause youre a member of the Biomedicine Discovery Institute

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For all stories in this issue of the BDI Newsletter and every past issue too visitwwwbdishynewslettercom