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CURRICULUM VITAE ANDREW J. GHIO, MD

Andrew Jonathan Ghio, M.D. Curriculum vitae

Date prepared: March 23, 2016

Current position: Medical OfficerClinical Research Branch, Environmental Public Health DivisionNational Health and Environmental Effects Research LaboratoryOffice of Research and DevelopmentUnited States Environmental Protection Agency

Professional address: Human Studies Facility Business phone: (919) 966-0670Environmental Protection AgencyCampus Box 7315104 Mason Farm RoadChapel Hill NC 27599-7315

Electronic mail (work):[email protected] ; FAX: (919) 966-6271

Home address: 401 Perry Creek Drive Home phone: (919) 408-0018Chapel Hill, NC 27514

Electronic mail (other): [email protected], [email protected], andrew [email protected]

Marital Status: Married Spouse’s name: Beth Ann Ghio

Children (Year born): Christine (1987), Kathleen (1989), Michael (1991), Caroline (1998)

Education: Boston College (Chem/Biology) Chestnut Hill, MA 1973-77 B.S.Boston Univ. School of Medicine Boston, MA 1977-81 M.D.University of Utah (Public Health) Salt Lake City, UT 1986-88Duke University (Statistics) Durham, NC 1988-90Duke University (Chemistry) Durham, NC 1991-93Univ. North Carolina (Mol. Biol.) Chapel Hill, NC 1995-97Univ. North Carolina (Mol. Biol.) Chapel Hill, NC 2000-01

Military: Lieutenant, Public Health Service, United States Navy, 1984-1985.Centers for Disease Control. Atlanta, GA.

Lieutenant-Commander, Public Health Service, United States Navy, 1985-1986.Centers for Disease Control. Atlanta, GA.Honorable discharge, 1986.

Captain, United States Army National Guard, 1987-1988.144th Evacuation Hospital, Salt Lake City, UT.Transferred to North Carolina National Guard, 1988.

Captain, United States Army National Guard, 1988-1992.823th Dispensary, Durham, NCOfficer in charge: Nuclear, biological, and chemical warfareHonorable discharge, 1992.

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mailto:[email protected]





Professional training and career:July 1981 - June 1982 St. Luke's-Roosevelt Medical Center, Columbia University, New York City, NY.

Internship in internal medicine. Dr. Edward Dwyer, Program DirectorJuly 1982 - June 1984 Mercy Hospital, Pittsburgh, PA.

Residency in internal medicine. Dr. Frances Luparello, Program Director

July 1984 - June 1986 Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control,

Morgantown, WV. Officer, Epidemiology Intelligence Service, Centers for Disease Control.Dr. John Hankinson, Branch Director

Jan. 1985 - Dec. 1985 National Institute for Occupational Safety and Health, Cincinnati, OH.Residency in occupational medicine. Dr. Shiro Tanaka, Program Director

July 1984 - June 1986 West Virginia University School of Medicine, Department of Internal Medicine, Pulmonary Division, Morgantown, WV. Adjunct Instructor of Internal Medicine. Dr. LeRoy Lapp, Division Director

July 1986 - June 1988 University of Utah, Department of Medicine, Division of Occupational, Pulmonary, and Critical Care Medicine, Salt Lake City, UT. Fellowship in pulmonary and critical care medicine. Dr. Atillio Renzetti and Dr. John R. Hoidal, Division Directors

July 1988 - June 1990 Duke University, Department of Medicine, Division of Pulmonary and Critical Care Medicine, Durham, NC.Associate in Medicine. Dr. James D. Crapo, Division Director.

July 1990 - Jan. 1995 Duke University, Department of Medicine, Division of Pulmonary and Critical Care Medicine, Durham, NC.Assistant Professor of Medicine. Quality Assurance Representative Dr. James D. Crapo, Division Director.

July 1992 - June 1998 Duke University, Integrated Toxicology Program, Durham, NC. FacultyJuly 1990 - 1995 Duke University, Marine Biomedical Center, Beaufort, NC. Scholar

Dr. Celia Bonaventura, Center DirectorJan. 1995 - Jan 2001 Duke University, Department of Medicine,

Division of Pulmonary and Critical Care Medicine, Durham, NC. Assistant Consulting Professor of Medicine

Dr. James D. Crapo, Division Director to 1997Dr. William Fulkerson, Division Director to 1999Dr. Neil MacIntyre, Division Director to 2000

April 2002 - Present Duke University, Department of Medicine, Division of Pulmonary and Critical Care Medicine, Durham, NC. Associate Consulting Professor of Medicine

Dr. David Schwartz, Division Director to 2004Dr. Neil MacIntyre, Division Director to 2006Dr. Paul Noble, Division Director to 2011Dr. Monica Kraft, Division Director to 2014

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Dr. Claude Piantadosi, Division Director to present

July 1988 - Jan. 1995 Durham VA Medical Center, Durham, NC. Staff Physician.Director, Pulmonary Function LaboratoryDirector, Bronchoscopy Services Chairman, Research Biosafety CommitteeMember, Professional Standards Committee

Dr. Steve L. Young, Section Chief to 1992Dr. Philip Fracica, Section Chief to 1994Dr. Michael Russell, Section Chief to 1995

Jan. 1995 - 2012 Durham VA Medical Center, Durham, NC. Staff Physician.Dr. Gilbert Schreiber, Section Chief to 2002Dr. Karen Welty-Wolf, Section Chief to 2012

Jan. 1995 - Present Clinical Research Branch, Human Studies Division, National Health and Environmental Effects Research Laboratory,

Environmental Protection Agency, Chapel Hill NC. Research Medical Officer

Dr. Robert B. Devlin, Branch Director to 2007Dr. David Diaz-Sanchez, Branch Director 2007 to present

Bronchoscopy CoordinatorNHEERL Technical Qualifications Board (TQB)Acting Branch Director (December, 2006 to February, 2007)Response Capability Enhancement Team, US EPA

Oct. 1997 - June, 2000 Center for the Study of Respirable Particles, Carolina Environmental Program, University of North Carolina, Chapel Hill, North Carolina. Dr. Scott Martin, Center Director

July 1999- June 2001 University of North Carolina, Department of MedicineDivision of Pulmonary and Critical Care Medicine, Chapel Hill, North CarolinaClinical Assistant Professor (Code Number 209262; PID Number 710817244)Dr. Richard Boucher, Division Director

June 2001- Present University of North Carolina, Department of MedicineDivision of Pulmonary and Critical Care Medicine, Chapel Hill, North CarolinaClinical Associate Professor (Code Number 20926)

Dr. Richard Boucher, Division Director to 2002Dr. Jim Donohue, Division Director 2002 to 2011Dr. Shannon Carson, Division Director 2011 to present

Feb. 2000 - June 2002 Chairman and Chest Consultant, Advisory Medical CommitteeDusty Trades Program, State Department of Health and Human ServicesRaleigh, North Carolina

January 2005 - Present Faculty member (Fixed Term), Toxicology curriculumUniversity of North Carolina, Chapel Hill, NC

July 2008 – Present Faculty member, North Carolina Translational and Clinical Sciences Institute (TraCS), University of North, Chapel Hill, NC

August 2012 - Present Faculty member (Fixed Term), The Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, NC

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2013 – 2016 Member, North Carolina State Bar, North Carolina Board of Legal Specialization

Medical licensure (National Boards, State):1982 National Board of Medical Examiners 249421 Active1982 Pennsylvania 028468 Inactive 1984 West Virginia 14089 Inactive1986 Utah 003063 Inactive1988 North Carolina 33046 Active1988 Medicaid Provider Number 9835242 Active1988 Drug Enforcement Agency BG1629267 Active

Specialty certification and dates:American Board of Internal Medicine. Certified, 1984. Candidate No. 098455.American Board of Internal Medicine, Subspecialty-Pulmonary Medicine. Certified, 1990.

Candidate No. 098455.American Board of Internal Medicine, Subspecialty-Pulmonary Medicine. Recertified, 2000.

Recertified 2012. Candidate No. 098455.American Board of Preventative Medicine, Subspecialty-Occupational Medicine, Eligible, 1988.American Association for Laboratory Animal Sciences, Assistant Laboratory Animal Technician,

Certified, 1990.B Reader Certification, National Institute for Occupational Safety and Health.

Certified: 1986 and recertified: 1990, 1996, 2000, 2004, 2008, 2012, and 2016B Reader, Division of Coal Mine Workers’ Compensation, US Department of Labor.B Reader, US Department of Defense, Department of Navy (Reader #400): 1999, 2004B Reader, North Carolina Advisory Medical Committee, State Public Health, Dusty Trades

Act, 2000B Reader, National Institute for Occupational Safety and Health, Coal Workers’ Health

Surveillance Program (CWHSP), 2005National Plan & Provider Enumeration System; NPI #1609949387Pulmonary Function Testing, National Institute for Occupational Safety and Health, Certified, 1986

Organizations and Participation:1979 - 1989 Physicians for Social Responsibility1979 - 1989 Union of Concerned Scientists1984 - 1991 American College of Chest Physicians

Southern Chapter1984 - 1991 American College of Physicians (#091463)

Western Pennsylvania/West Virginia Chapter Utah Chapter North Carolina Chapter

1986 - Present American Thoracic Society (#00009718)Scientific Assembly on Environmental and Occupational Health Program Committee

West Virginia Thoracic Society Intermountain Thoracic Society North Carolina Thoracic Society

1988 - 1990 American College of Occupational Medicine

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1988 - 1990 Carolina Occupational Medical Association1989 - Present American Physiological Society (#00007651)

Respiration Section1990 - Present American Heart Association

Cardio-Pulmonary Council1990 - Present The Oxygen Society1990 - 1993 American Society of Internal Medicine2004 - Present Society of Toxicology (#2897546)2004 – 2008 Society of Toxicologic Pathology2004 - 2007 American Public Health Association (#9810961)2006 - Present Genetics and Environmental Mutagenesis Society (GEMS)2006 - Present International BioIron Society (#50301)2006 - 2008 American Chemical Society2013 – 2014 International Association of Wildland Fire

Editorial Board Membership:Biochimica et Biophysica Acta (2006- present)BMC Particle and Fibre Toxicology (2003- 2013)Inhalation Toxicology (2001- 2013)The Open Cardiovascular & Thoracic Surgery Journal (2008-2011)Inhalation Toxicology, Associate Editor (2016- present)

Journal Review (Ad hoc):Aerosol Science and Technology; American Journal of Respiratory and Critical Care Medicine; American Journal of Respiratory Cell and Molecular Biology; American Journal of Physiology, Cell Physiology; American Journal of Physiology, Lung Cellular and Molecular Physiology; Annals of Occupational Hygiene; Annals of Respiratory Medicine; Arthritis and Rheumatism; Atmospheric Environment; Applied Occupational and Environmental Hygiene; Archives of Biochemistry and Biophysics; Biochimica et Biophysica Acta; Biochimie; Biological Trace Element Research; Biomaterials; Biomarkers and Prevention; Brain Research Bulletin; British Journal of Medicine and Medical Research; Cancer Epidemiology; Cell Biology and Toxicology; Chemical Research in Toxicology; Chemico Biological Interactions; Chest; Clinical Medicine: Circulatory, Respiratory and Pulmonary Medicine; COPD: Journal of Chronic Obstructive Pulmonary Disease; Critical Care Medicine; Croatian Medical Journal; eBiomedicine; Environmental Health Insights; Environmental Health Perspectives; Environmental Pollution; Environmental Research; Environmental Science and Pollution Research; Environmental Science & Technology; Environmental Toxicology; Environmental Toxicology and Pharmacology; European Journal of Applied Physiology; European Journal of Pharmacology; European Respiratory Journal; Experimental Lung Research; Food and Chemical Toxicology; Free Radical Biology & Medicine; Fuel; Fundamental and Applied Toxicology; Future Cardiology; International Blood Research & Reviews; International Immunopharmacology; International Journal of Biological Sciences; International Journal of Chronic Obstructive Pulmonary Disease; International Journal of Environmental Research and Public Health; International Journal of Hygiene and Environmental Health; International Research Journal of Microbiology; International Journal of Nanomedicine.; Journal of the Air & Waste Management Association; Journal of Applied Physiology; Journal of Applied Toxicology; Journal of Biological Regulators and Homeostatic Agents; Journal of Biomedicine and Biotechnology; Journal of Breath Research; Journal of Clinical Investigation; Journal of Diabetes and Its

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Complications; Journal of Environmental Research and Public Health; Journal of Investigative Medicine; Journal of Laboratory and Clinical Medicine; Journal of Respiratory Medicine; Journal of Leukocyte Biology; Journal of Nutritional & Environmental Medicine; Journal of Physiology; Journal of Respiratory Medicine; Journal of Toxicology and Environmental Health; Medical Science Monitor; Metabolism; Microbeam Analysis; Microscopy Regulatory Toxicology and Pharmacology; Research and Technique; Molecular and Cellular Biochemistry; Mutation Research; Naunyn-Schmiedeberg's Archives of Pharmacology; The Open Cardiovascular And Thoracic Surgery Journal; Pediatric Pulmonology; Pharmacological Research; Planta Medica; PLoS One; Respiratory Medicine; Respiratory Research; Scientific Reports; Science of the Total Environment; Swiss Medical Weekly; Toxicologic and Environmental Chemistry; Toxicological Sciences; Toxicology and Applied Pharmacology; Toxicology Letters; Translational Research; Turkish Thoracic Journal

Grant Review Section committees:American Heart Association (2004)Defense and Health Research Program, United States Department of Defense (2000)Flight Attendant Medical Research Institute/Molecular Biology Section (2001-2005)National Institutes of Health, National Institute of General Medical Sciences/Minority Biomedical

Research Support- SCORE research projects (2007)Veterans Administration Merit Review of Gulf War and Deployment Health Meeting (2004)Veterans Administration Merit Review of Gulf War Health Meeting (2005)

Ad hoc:Defense and Health Research Program (United States Department of Defense)Environmental Protection Agency Grant Program (STAR)Environmental Protection Agency, Office of Research and Development, National Center for

Environmental Research (National Research Center)Flight Attendant Medical Research Institute/Molecular Biology Section and Centers of Excellence

SectionHealth Effects Institute Grant ProgramItalian Cystic Fibrosis Research FoundationNational Sciences and Engineering Research Council of CanadaPhilip Morris External Research ProgramSouth African National Research FoundationThrasher Research FundVeterans Administration Merit Review Grant ProgramThe Wellcome Trust

Professional Awards and Special Recognitions: 1977 Summa Cum Laude, Boston College1977 Phi Beta Kappa, Boston College chapter1977 Alvan T. and Viola D. Fuller American Cancer Society Junior Research Fellowship

Award. Investigation mentored by Dr. Jerry Williams, D.Sc. Harvard Medical School. Boston, MA.

1987 First Prize, Scientific Presentation to American College of Physicians, Utah Annual Meeting.

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1988 DuPont Critical Care/American College of Chest Physicians Young InvestigatorAward

1990 Fellow, American College of Physicians1991 Physician Scientist Award, National Heart, Lung, and Blood Institute,

National Institutes of Health.1997 Scientific and Technological Achievement Award (Level II), Environmental

Protection Agency. The role of metal-catalyzed oxidants in particle toxicity.1998 Scientific and Technological Achievement Award (Level II), Environmental

Protection Agency. The role of lactoferrin and ferritin in injury after particleexposure.

2000 Scientific and Technological Achievement Award (Level II), Environmental Protection Agency. Concentrated ambient particles induce a neutrophilic lung inflammation in healthy volunteers.

2000 Scientific and Technological Achievement Award (Level III), Environmental Protection Agency. Soluble transition metals mediate residual oil fly ash induced acute lung injury.

2001 Scientific and Technological Achievement Award (Level I), Environmental Protection Agency. Air Pollution Particles from the Utah Valley Cause Lung Injury and Inflammation in Humans and Animals

2002-present Listed in Marquis’ Who's Who in Medicine and Healthcare 2003-present Listed in Marquis’ Who's Who in Science and Engineering 2004-present Listed in Marquis’ Who's Who in Executives and Professionals2005-present Listed in Marquis’ Who's Who in the World 2005-present Listed in Strathmore’s Who’s Who2003 Gold Medal for involvement in the National Health and Environmental Effects

Research Laboratory Particulate Matter Health Research Team, Environmental Protection Agency

2004 Exceptional/outstanding ORD technical assistance to the regions or program offices, Environmental Protection Agency

2005 Listed in Guide to America’s Top Physicians2005 Scientific and Technological Achievement Award (Level III), Environmental

Protection Agency. Formation of 8-oxo-dG in Rat Lung DNA Following Subchronic Inhalation of Carbon Black and Air Pollution Mediated Oxidative DNA Damage in Cell Free Systems and Human Airway Epithelial Cells in Relation to Particle Metal Contents and Bioreactivity.

2007 Scientific and Technological Achievement Award (Level III), Environmental Protection Agency. Disruption of iron homeostasis as a mechanism of biologic effect by ambient air pollution particles, DMT1 decreases metal-related injury in the lung, and TNF, IFN-gamma, and endotoxin increase expression of DMT1 in bronchial epithelial cells.

2008 Top 100 Scientists, 2008. Sponsored & administered by the International Biographical Centre, Cambridge, England.

2011-present Listed in Marquis’ Who's Who in the America 2011 Scientific and Technological Achievement Award (Honorable mention),

Environmental Protection Agency. Complex Issues with Examining Diesel Exhaust Toxicity: is the Task Getting Easier or Harder in Experimental and Toxicological Pathology, 60:135-140 (2008) and Biodiesel Exhaust: The Need for Health Effects

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Research in Environmental Health. Perspectives, 115:496-499 (2007).2011 Alice Hamilton Award for excellence in occupational safety and health. Presented

by the National Institute for Occupational Safety and Health for leadership through science by publishing: Sriram K, Lin GX, Jefferson AM, Roberts JR, Wirth O, Hayashi Y, Krajnak KM, Soukup JM, Ghio AJ, Reynolds SH, Castranova V, Munson AE, Antonini JM. Mitochondrial dysfunction and loss of Parkinson's disease-linked proteins contribute to neurotoxicity of manganese-containing welding fumes. FASEB J 2010; 24: 4989-5002.

2011 Charles C. Shepard Science Award. Laboratory and Methods: Sriram K, Lin GX, Jefferson AM, Roberts JR, Wirth O, Hayashi Y, Krajnak KM, Soukup JM, Ghio AJ, Reynolds SH, Castranova V, Munson AE, Antonini JM. Mitochondrial dysfunction and loss of Parkinson's disease-linked proteins contribute to neurotoxicity of manganese-containing welding fumes. FASEB J 2010; 24: 4989-5002.

2012 Scientific and Technological Achievement Award (Level III), Environmental Protection Agency. Effect of Size-Fractional on the Toxicity of Amosite and Libby Amphibole Asbestos.

2012 Scientific and Technological Achievement Award (Honorable mention), Environmental Protection Agency. Cumulative Exposure Assessment for Trace-Level Polycyclic Aromatic Hydrocarbons (PAHs) Using Human Blood and Plasma Analysis.

2013 Scientific and Technological Achievement Award (Level III), Environmental Protection Agency. (1) Subchronic Pulmonary Pathology, Iron Overload, and Transcriptional Activity after Libby Amphibole Exposure in Rat Models of Cardiovascular Disease Environmental Health Perspectives, 120(1):85-91 (2012); (2) The role of iron Libby amphibole-induced acute lung injury and inflammation Inhalation Toxicology, 23(6):313-323 (2011); (3) Transcriptional activation of inflammasome components by Libby amphibole and the role of iron Inhalation Toxicology, 24(1):60-69 (2012).

2014 Bronze Medal for involvement in the Human Research Medical and Ethics Team, Environmental Protection Agency.

Clinical and teaching activities: West Virginia University School of Medicine and Medical Center (1984 to 1986)

Attending Physician, West Virginia University Hospital, Pulmonary Outpatient Clinic.Occupational Medicine Lectures- Industrial Hygiene students.

Duke University School of Medicine and Medical Center (1988 to present)Attending Physician, Duke University General Medical Service.Attending Physician, Durham VA General Medical Service.Attending Physician, Durham VA Pulmonary Outpatient Clinic. Attending Physician, Durham VA Pulmonary Consult Service. Attending Physician, Durham VA Medical Intensive Care Unit.Pulmonary and Critical Care Medicine Lectures- Fellows’ conferencePulmonary and Critical Care Medicine Lectures- Second year medical studentsPulmonary and Critical Care Medicine Lectures- Physician assistants.Physical Examination Lectures- First year medical students.Epidemiology Course mentorship- Physician assistants.Pulmonary Medicine Lectures- Physician assistants

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University of North Carolina School of Medicine and Medical Center (1998 to present)Attending Physician, Fellows Clinic, University of North Carolina, Ambulatory Care

Center.Pulmonary Medicine Lectures- Pulmonary fellows.Pulmonary and Critical Care- Research conferenceAir Pollution Epidemiology Lectures, Epidemiology- Pre-doctoral and post-doctoral

students.Toxicology core courses- Pre-doctoral students.School of Public Health- Masters students.

Areas of research interest: Environmental and occupational pulmonary medicineRole of iron in lung injuryRole of oxidants in lung injury

Research training:Pulmonary and Critical Care Fellows (Duke University):

Robert J. Pritchard, MD (1992-1994)Rajesh Bhagat, MD (Advisory Committee; 2001-2002)Armin Meyer, MD (2002-2003)

Pediatric Intensive Care Fellow (Duke University): Jennifer Turi, MD (1999-2001)

Pulmonary and Critical Care Fellows (University of North Carolina): Chris Pugh, MD (2002-2003)Thaw Sint (2005-2006)

Physicians:Rahul Sangani (2008-2010)

Post-doctoral Students (University of North Carolina):Xinchao Wang, MD, MPH (2000-2003)Zhongping Deng, Ph.D, MD (2005-2007)

Pre-doctoral Students (University of North Carolina):Alejandro R. Molinelli UNC Toxicology (2000-2001)Jonathan Shannahan UNC Toxicology (2008- 2011)Shalini Minocha, UNC Eshelman School of Pharmacy (2010- 2012)Andres Henriquez, UNC Toxicology (2012-)Desinia Johnson, UNC Toxicology (2013-)

Pre-doctoral Students (Harvard University):Elizabeth Heilig Thesis Defense Committee (November 9, 2005)

Pre-doctoral Students (Northwestern University):Alejandro P. Comellas, MD, (Advisory Committee; 2007)

Masters Students (University of North Carolina):Kimberly Swanson (2005-2006)

Undergraduate Students (University of North Carolina)Richard Grant Muller (2011)

Summer Students:Aaron Hall, University of North Carolina (2002)Amruta Sarma, Princeton University (2005)Jennifer Huang, East Chapel Hill High School, Chapel Hill, NC (2008)

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Suryanaren Kummarapurugu, Chapel Hill High School, Chapel Hill, NC (2012)

Patents:1. Ghio AJ, Piantadosi CA, and Kennedy TP. Method of inhibiting oxidants using alkylaryl polyether alcohol polymers. Filed 3/29/94. Issued 12/12/95 as U.S. Patent No. 5,474,760.2. Ghio AJ, Piantadosi CA, and Kennedy TP. Method of inhibiting oxidants using alkylaryl polyether alcohol polymers. U. S. Serial No. 08/299,316. Filed 8/31/94. Issued 4/30/96 as U.S. Patent No. 5,512,270.

Ghio AJ, Piantadosi CA, and Kennedy TP. Method of inhibiting oxidants using alkylaryl polyether alcohol polymers. Foreign patent applications PCT/US94/03460. Filed 3/30/94.Canada Patent File No. 2,102,142. March 30, 1994.

Patent File No. 2,159,485. March 30, 1994. Australia Application No. 65273/94. March 30, 1994. Europe Application No. 94912904.3. March 30, 1994. Designates Austria,

Belgium, Denmark, France, Germany, Greece, Ireland, Italy, Portugal, Netherlands, Spain, Sweden, Switzerland, Great Britain.

Japan Application No. 522323/1994. March 30, 1994. Korea Application No. 95-704225. March 30, 1994. New Zealand Application No. 263986. March 30, 1994. New Zealand Application No. 328206. March 30, 1994. Russia Application No. 95118289; Patent Application No. 95 118 289. March 30,

1994. Issued on October 25, 1999 as Russian Letters Patent No. 2147235. 3. Ghio AJ, Piantadosi CA, and Kennedy TP. Method of mucociliary clearance in cystic fibrosis patients using alkylaryl polyether alcohol polymers. U. S. Serial No. 08/413,699. Filed 3/30/95. Issued 11/03/98 as U.S. Patent No. 5,830,436.

Ghio AJ, Piantadosi CA, and Kennedy TP. Method of mucociliary clearance in cystic fibrosis patients using alkylaryl polyether alcohol polymers. Foreign patent applications.Canada Patent File No. 2216789. March 29, 1996.Australia Application No. 5435896. March 29, 1996.Europe Application No. 96911482.6. March 29, 1996. Designates Austria,

Belgium, Denmark, France, Germany, Greece, Ireland, Italy, Portugal, Netherlands, Spain, Sweden, Switzerland, Great Britain.

Japan Application No. 8-529663. March 29, 1996.4. Ghio AJ, and Kennedy TP. Pharmaceutical compositions containing alkylaryl polymer alcohol polymer. U.S. Application Serial No. 08/638,893. Filed 4/25/96. Issued 11/24/98 as U.S. Patent No. 5,840,277

Ghio AJ, and Kennedy TP. Pharmaceutical compositions containing alkylaryl polyether alcohol polymer. Foreign patent applications PCT/US97/06862. Filed 4/25/96.Australia Application No. 6527394. Granted. 6/26/97. New Zealand Filed 7/19/97.

5. Ghio AJ, and Kennedy TP. Treatment of chronic pulmonary inflammation. U. S. Serial No. 08/632,275. U. S. Application Serial No. 09/097,929. Filed 6/16/98. Issued 02/15/00 as U.S. Patent No. 6,024,940

Ghio AJ, and Kennedy TP. Treatment of chronic pulmonary inflammation. Foreign patent applications.Europe Application No. PCT/US97/06150. Designates Austria, Belgium,

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Denmark, France, Germany, Greece, Ireland, Italy, Portugal, Netherlands,Spain, Sweden, Switzerland, Great Britain.

6. Schmechel D, Ghio A, Piantadosi C. Biomarkers of oxidative stress in acute and chronic neuropsychiatric illness.

Manuscripts: Published in Refereed Journals1. Ghio AJ, Crapo RO. Midcycle pneumothorax in a patient with catamenial pneumothoraces.

Western Journal of Medicine 1988; 149 (4): 462-463. 2. Ghio AJ, Elliott CG, Crapo RO, Jensen RI, Berlin SL. Impairment following Adult Respiratory

Distress Syndrome: An evaluation based on American Thoracic Society's recommendations. American Review of Respiratory Disease 1989; 139 (5): 1158-1162.

3. Ghio AJ, Elliott CG, Crapo RO, Collins MP, Tocino I. Migratory infiltrates in a patient with hemoptysis. Chest 1989; 96 (1): 95-196.

4. Ghio AJ, Crapo RO, Elliott CG, Adams TD, Hunt SC, Jensen RI, Fisher AG, Afman GR. Heritability estimates of pulmonary function. Chest 1989; 96 (4): 743-746.

5. Ghio AJ, Crapo RO, Elliott CG. Survey of the use of reference equations to predict pulmonary function at North American training programs in respiratory disease. Chest 1990; 97 (2): 400-403.

6. Ghio AJ, Crapo RO, Elliott CG. Letter to the Editor: Survey of reference equations used to predict pulmonary function in children. Pediatric Pulmonology 1990; 8 (2): 126-127.

7. Ghio AJ, Kennedy TP, Schapira RM, Crumbliss AL, Hoidal JR. Hypothesis: Lung disease following silicate exposure results from oxidants generated via the Fenton reaction. Lancet 1990; 336: 967-969.

8. Ghio AJ, Worley RJ, McCusker K. Letter to the Editor: Hydropneumothorax complicating recruitment of oocytes for in vitro fertilization. Southern Medical Journal 1990; (6): 726-727.

9. Guo Y-L, Kennedy TP, Michael JR, Sciuto AM, Ghio AJ, Adkinson NF Jr, Gurtner GH. Mechanism of phosgene-induced lung toxicity: Role of arachidonate mediators. Journal of Applied Physiology 69 (5): 1615-1622, 1990.

10. Ghio AJ, Kennedy TP. Kaolin pneumoconiosis. East Texas Medicine Journal 1990; 2 (1): 32-36.11. Ghio AJ, Castellon RI, Kinsley KB, Hankinson JL. Changes in forced expiratory volume in one

second and peak expiratory flow rate across a workshift among unexposed blue collar workers. American Review of Respiratory Disease 1991; 143: 1231-1234.

12. Ghio AJ, Kennedy TP, Hatch GE, Tepper JS. Reduction of PMN influx diminishes lung injury and mortality following phosgene inhalation. Journal of Applied Physiology 71 (2): 657-665, 1991.

13. Ghio AJ, Peterseim DL, Roggli VL, Piantadosi CA. Pulmonary oxalate deposition associated with Aspergillus niger infection: An oxidant hypothesis of toxicity. American Review of Respiratory Disease 1992; 145: 1499-1502.

14. Ghio AJ, Hatch GE. Colchicine inhibits elevations in both alveolar-capillary membrane permeability and lavage surfactant after exposure of the rat to phosgene. Inhalation Toxicology 1992; 4: 383-392.

15. Ghio AJ, Kennedy TP, Whorton AR, Crumbliss AL, Hatch GE, Hoidal JR. The role of surface complexed iron in oxidant generation and lung inflammation induced by silicates. American Journal of Physiology, Lung Cellular and Molecular Physiology 1992; 263: L511-L518.

16. Ghio AJ, Zhang J, Piantadosi CA. Generation of hydroxyl radical by crocidolite increases with surface [Fe3+]. Archives of Biochemistry and Biophysics 1992; 298: 646-650.

17. Ghio AJ, Hatch GE. Lavage phospholipid concentration after silica instillation in the rat is associated with complexed [Fe3+] on the dust surface. American Journal of Respiratory Cell and Molecular Biology 1993; 8: 403-407.

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18. Ghio AJ, Kennedy TP, Stonehuerner JG, Crumbliss AL, Hoidal JR. DNA strand breaks following in vitro exposure to asbestos increase with surface-complexed [Fe3+]. Archives of Biochemistry and Biophysics 1994; 311:13-18 .

19. Ghio AJ, Kennedy TP, Cooke CL, Miller MJ, Rao G, Hoidal JR. Surface complexation of iron cations by sodium urate crystals and gouty inflammation. Archives of Biochemistry and Biophysics 313:215-221, 1994.

20. Ghio AJ, Stonehuerner J, Quigley DR. Humic-like substances in cigarette condensate and lung tissue of smokers. American Journal of Physiology, Lung Cellular and Molecular Physiology 1994; 266:L382-L388.

21. Ghio AJ, Quigley DR. Complexation of iron by humic-like substances in lung tissue: role in Coal Worker's Pneumoconiosis. American Journal of Physiology, Lung Cellular and Molecular Physiology 267:L173-L179, 1994.

22. Ghio AJ, Jaskot RH, and Hatch GE. Collagen deposition after intratracheal instillation of silica is associated with an accumulation of non-heme iron in the rat lung. American Journal of Physiology, Lung Cellular and Molecular Physiology 1994; 267:L686-L692.

23. Schapira RM, Ghio AJ, Effros RM, Morrisey J, Dawson CA, and Hacker AD. Hydroxyl radicals are formed in the rat lung following asbestos instillation in vivo. American Journal of Respiratory Cell and Molecular Biology 1994; 10:573-579.

24. Ghio AJ, Stonehuerner J, Steele MP, and Crumbliss AL. Phagocyte generated superoxide displaces Fe3+ from surface of asbestos. Archives of Biochemistry and Biophysics 1994; 315:219-225.

25. Ghio AJ, Fracica PJ, Young SL, and Piantadosi CA. Synthetic surfactants scavenges oxidants and protects against hyperoxic lung injury. Journal of Applied Physiology 77 (3):1217-1223, 1994.

26. Taylor DE, Ghio AJ, and Piantadosi CA. Reactive oxygen species produced by liver mitochondria of septic rats. Archives of Biochemistry and Biophysics 316:70-76, 1995.

27. Ghio AJ, Crumbliss AL. Book Review: The Development of Iron Chelators for Clinical Use. Free Radical Biology & Medicine 1995; 19 (1):129-130.

28. Schapira RM, Ghio AJ, Effros RM, Morrisey J, Almagro UA, Dawson CA, and Hacker AD. Hydroxyl radical production and injury in the rat lung following silica or titanium dioxide instillation. American Journal of Respiratory Cell and Molecular Biology 12:220-226, 1995.

29. Oury TD, Tatro L, Ghio AJ, Piantadosi CA. Nitration of tyrosine by hydrogen peroxide and nitrite. Free Radical Research 23 (6):537-547, 1995.

30. Ghio AJ, Roggli VL. Mycotoxins and interstitial lung disease. Chest 108 (5): 1185-86, 1995.31. Ghio AJ, Meyer GA, and Crapo RO. The association of pulmonary artery size on chest radiograph

with residence at altitude. Journal of Thoracic Imaging 11:53-57, 1996.32. McDonald JW, Ghio AJ, Bernhardt PF, Roggli VL. Rare Earth (cerium oxide) Pneumoconiosis:

analytical scanning electron microscopy, in vitro and animal studies, and literature review. Modern Pathology 8 (8): 859-865, 1995.

33. Ghio AJ, Hatch GE. Tolerance to phosgene is associated with a neutrophilic influx into the rat lung. American Journal of Respiratory and Critical Care Medicine 153:1064-1071,1996.

34. Pritchard RJ, Ghio AJ, Lehmann JR, Winsett DW, Tepper JS, Park P, Gilmour MI, Dreher KL, Costa DL. Oxidant generation and lung injury after particulate air pollution exposure increase with the concentrations of associated metals. Inhalation Toxicology 8:457-477, 1996.

35. Ghio AJ, Pritchard RJ, Lehman JR, Winsett DW, Hatch GE. Lung inflammation after exposure to non-fibrous silicates increases with chelatable [Fe3+]. Journal of Toxicology and Environmental Health 49 (1):11-28, 1996.

36. Ghio AJ, Stonehuerner J, Pritchard RJ, Piantadosi CA, Quigley DR Dreher KL, Costa DL. Humic-like substances in air pollution particulates correlate with concentrations of transition metals and

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oxidant generation. Inhalation Toxicology 8:479-494, 1996.37. Pracyk JB, Simonson SG, Young SL, Ghio AJ, Roggli VL, Piantadosi CA. Composition of lung

lavage in pulmonary alveolar microlithiasis. Respiration 1996; 63:254-260.38. Ghio AJ, Roggli VL. The accumulation of iron in the rat lung after intratracheal instillation of coal

dust. Applied Occupational and Environmental Hygiene 11 (7):980-985, 1996.39. Ghio AJ, Marshall B, Diaz JL, Povia D, Kennedy TP, Piantadosi CA. Tyloxapol inhibits cytokine

release, scavenges HOCl, and is mucolytic for CF sputum. American Journal of Respiratory and Critical Care Medicine 154 (3):783-788, 1996.45

40. Samet JM, Madden MC, Ghio AJ, Devlin RB, Carter J, Reed W. Induction of prostaglandin H synthase 2 in cultured airway epithelial cells exposed to residual oil fly ash. Toxicology and Applied Pharmacology 1996; 141:159-168.

41. Ghio AJ, LeFurgey A, Roggli VL. The in vivo accumulation of iron on crocidolite is associated with decrements in oxidant generation by the fiber. Journal of Toxicology and Environmental Health 1997; 50:125-142.

42. Ghio AJ, Stonehuerner J. Complement activation after in vitro asbestos exposure corresponds to oxidant generation by the fiber. Inhalation Toxicology 1997; 9:31-41.

43. Ghio AJ, Pritchard RJ, Dittrich K, Samet JM. Non-heme [Fe3+] in the lung increases with age in both the rat and man. Journal Laboratory Clinical Medicine 1997; 129:53-61.

44. Ghio AJ, Meng ZH, Hatch GE, Costa DL. Luminol-enhanced chemiluminescence after in vitro exposure of rat alveolar macrophages to oil fly ash is metal dependent. Inhalation Toxicology 1997; 9:255

45. Dreher KL, Jaskot RH, Lehmann JR, Richards JH, McGee JK, Ghio AJ, Costa DL. Soluble transition metals mediate residual oil fly ash induced acute lung injury. Journal of Toxicology and Environmental Health 1997; 50:285-305.

46. Samet JM, Stonehuerner J, Reed W, Devlin RB, Dailey LA, Kennedy TP, Ghio AJ. Disruption of protein tyrosine phosphate homeostasis in bronchial epithelial cells exposed to oil fly ash. American Journal of Physiology, Lung Cellular and Molecular Physiology 1997; 272:L426-L432.

47. Kodavanti UP, Jaskot RH, Su WY, Costa DL, Ghio AJ, Dreher KL. Genetic variability in combustion particle-induced chronic lung injury. American Journal of Physiology, Lung Cellular and Molecular Physiology 1997; 272:L521-L532.

48. Ghio AJ, Piantadosi CA, and Crumbliss AL. The role of iron in neutrophilic inflammation. Biometals 1997; 10:135-142.

49. Baz MA, Ghio AJ, Roggli VL, Tapson VF, Piantadosi CA. Iron accumulation in lung allografts after transplantation. Chest 1997; 112:435-439.

50. Kadiiska MB, Mason RP, Dreher KL, Costa DL, Ghio AJ. In vivo evidence of free radical formation in the rat lung after exposure to an emission source air pollution particle. Chemical Research in Toxicology 1997; 10:1104-1108.

51. Carter JD, Ghio AJ, Samet JM, Devlin RB. Cytokine production by human airway epithelial cells after exposure to an air pollution particle is metal-dependent. Toxicology and Applied Pharmacology 1997; 146:180-188.

52. Ghio AJ, Carter JD, Samet JM, Quay J, Wortman IA, Richards JH, Kennedy TP, Devlin RB. Post-transcriptional regulation of ferritin expression after in vitro exposures of human alveolar macrophages to silica is iron-dependent. American Journal of Respiratory Cell and Molecular Biology 1997; 17:533-540. Cover picture.

53. Ghio AJ, Kadiiska MB, Xiang Q, Mason RP. In vivo evidence of free radical formation after asbestos instillation: an ESR spin trapping investigation. Free Radicals Biology & Medicine 1998; 24:11-17.

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54. Ghio AJ, Taylor DE, Stonehuerner JS, Crumbliss AL, Piantadosi CA. The release of iron from different asbestos structures by hydrogen with concomitant O2 generation. Biometals 1998; 11:41-47.

55. Ghio AJ, Carter JD, Richards JH, Brighton LE, Lay JC, Devlin RB. Disruption of normal iron homeostasis after bronchial instillation of an iron-containing particle. American Journal of Physiology, Lung Cellular and Molecular Physiology 1998; 274:L396-L403.

56. Ghio AJ, Carter JD, Samet JM, Reed W, Quay J, Dailey LA, Richards JH, Devlin RB. Metal-dependent expression of ferritin and lactoferrin by respiratory epithelial cells. American Journal of Physiology, Lung Cellular and Molecular Physiology 1998; 274:L728-L736.

57. Ghio AJ, Kennedy TP, Crissman KM, Richards JH, Hatch GE. Depletion of iron and ascorbate in rodents diminishes lung injury after silica. Experimental Lung Research 1998; 24:219-232.

58. Ghio AJ, Richards JH, Dittrich KL, Samet JM. Metal storage and transport proteins increase after exposure of the rat lung to an air pollution particle. Toxicologic Pathology 1998;26:388-394.

59. Ghio AJ, Bassett M, Chall AN, Levin DG, Bromberg PA. Bronchoscopy in healthy volunteers. Journal of Bronchology 1998; 5:185-194.

60. Kennedy TP, Ghio AJ, Reed W, Samet J, Zagorski J, Quay J, Carter JD, Dailey LA, Hoidal JR, Devlin RB. Copper-dependent inflammation and NF-κB activation by particulate air pollution. American Journal of Respiratory Cell and Molecular Biology 1998; 19:366-378.

61. Carraway MS, Ghio AJ, Taylor JL, Piantadosi CA. Induction of ferritin and heme oxygenase-1 by endotoxin in the lung. American Journal of Physiology, Lung Cellular and Molecular Physiology 1998; 275:L583-L592.

62. Samet JM, Graves LM, Quay J, Dailey LA, Devlin RB, Ghio AJ, Bromberg PA, Reed W. Activation of MAP kinases in human bronchial epithelial cells exposed to metals. American Journal of Physiology, Lung Cellular and Molecular Physiology 1998; 275:L551-L558.

63. Ghio AJ, Stonehuerner J, Dailey LA, Carter JD. Metals associated with both the water-soluble and insoluble fractions of an ambient air pollution particle catalyze an oxidative stress. Inhalation Toxicology 1999; 11:37-49.

64. Ghio AJ, Stonehuerner J, McGee JK, Kinsey JS. Sulfate content correlates with iron concentrations in ambient air pollution particles. Inhalation Toxicology 1999; 11:293-307.

65. Lay JC, Bennett WD, Ghio AJ, Bromberg PA, Costa DL, Kim CS, Koren HS, Devlin RB. Cellular and biochemical response of the human lung after intrapulmonary instillation of ferric oxide particles. American Journal of Respiratory Cell and Molecular Biology 1999; 20:631-642.

66. Ghio AJ, Carter JD, Dailey LA, Devlin RB, Samet JM. Respiratory epithelial cells demonstrate lactoferrin receptors which increase after metal exposure. American Journal of Physiology, Lung Cellular and Molecular Physiology 1999; 276:L933 -L940.

67. Madden MC, Thomas, MJ, Ghio AJ. Acetaldehyde (CH3CHO) production in rodent lung after exposure to metal-rich particles. Free Radical in Biology & Medicine 1999; 26:1569-1577.

68. Sachs S, Ghio AJ, Young SL. Tyloxapol confers durable protection against hyperoxic lung injury in the rat. Experimental Lung Research 1999; 25:543-559.

69. Prahalad AK, Soukup JM, Inmon J, Willis R, Ghio AJ, Becker S, Gallagher JE. Air pollution particles: Effects on cellular oxidant radical generation in relation to particulate elemental chemistry. Toxicology and Applied Pharmacology 1999; 158:81-91.

70. Frampton MW, Ghio AJ, Samet JM, Carson JL, Carter JD, and Devlin RB. Effects of aqueous extracts of PM10 filters from the Utah Valley on human airway epithelial cells. American Journal of Physiology, Lung Cellular and Molecular Physiology 1999; 277 (21):L960-L967.

71. Carraway MS, Ghio AJ, Carter JD, Piantadosi CA. Expression of HO-1 in the lung in chronic hypoxia. American Journal of Physiology, Lung Cellular and Molecular Physiology 2000;

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278:L806-L812.72. Yang F, Coalson JJ, Bobb HH, Banu J, Ghio AJ. Resistance of hypotransferrinemic mice to

hyperoxia-induced lung injury. American Journal of Physiology, Lung Cellular and Molecular Physiology 1999; 277:L1214-L1223.

73. Samet JM, Ghio AJ, and Madden MC. Increased expression of cyclooxygenase 2 mediates oil fly ash-induced lung injury. Experimental Lung Research 2000; 26:57-69.

74. Soukup JM, Ghio AJ, Becker S. Soluble components of Utah Valley particulate pollution alter alveolar macrophage function in vivo and in vitro. Inhalation Toxicology 2000; 12:401-414.

75. Carraway MS, Ghio AJ, Carter JD, Piantadosi CA. Patients with pulmonary alveolar proteinosis are not deficient in GM-CSF. American Journal of Respiratory and Critical Care Medicine 2000; 161:1294-1299.

76. Ghio AJ, Roggli VL, Kennedy TP, and Piantadosi CA. Calcium oxalate and iron accumulation in sarcoidosis. Sarcoidosis, Vasculitits, and Diffuse Lung Diseases 2000; 17:140-150.

77. Silbajoris R, Ghio AJ, Samet JM, Jaskot R, Dreher KL, Brighton LE. In vivo and in vitro correlation of pulmonary MAP kinase activation following metallic exposure. Inhalation Toxicology 2000; 12:453-468.

78. Welty-Wolf KE, Carraway MS, Ghio A, Kantrow SP, Huang Y-CT, Piantadosi CA. Pro-inflammatory cytokines increase in sepsis after anti-adhesion molecule therapy. Shock 2000; 13:404-409.

79. Ghio AJ, Carter JD, Richards JH, Crissman KM, Bobb HH, Yang F. Diminished injury in hypotransferrinemic mice after exposure to a metal-rich particle. American Journal of Physiology, Lung Cellular and Molecular Physiology 2000; 278:L1051-L1061.

80. Ghio AJ, Richards JH, Carter JD, Madden MC. Accumulation of iron in the rat lung after tracheal instillation of diesel particles. Toxicologic Pathology 2000; 28 (4):619-627.

81. Ghio AJ, Richards JH, Carter JD. Iron disequilibrium in the rat lung after instilled blood. Chest 2000; 118:814-823.

82. Ghio AJ, Kim C, Devlin RB. Concentrated ambient particles induce a neutrophilic lung inflammation in healthy volunteers. American Journal of Respiratory and Critical Care Medicine 2000; 162 (3):981-998.

83. Yang F, Ghio AJ, Herbert DC, Weaker FJ, Walter CC, Coalson JJ. Pulmonary expression of the human haptoglobin gene. American Journal of Respiratory Cell and Molecular Biology 2000; 23 (3):277-282.

84. Watford WT, Ghio AJ, Wright JR. Functional complement-mediated in human bronchoalveolar lavage fluid. American Journal of Physiology, Lung Cellular and Molecular Physiology 2000;279:L790-L798.

85. Prahalad AK, Inmon J, Ghio AJ, Gallagher JE. Enhancement of 2'-deoxyguanosine hydroxylation and DNA damage by coal and oil fly ash in relation to particulate metal content and availability. Chemical Research in Toxicology 2000; 13 (10):1011-1019.

86. Madden MC, Richards J, Dailey LA, Hatch G, Ghio AJ. Effect of ozone on diesel exhaust particle toxicity in rat lung . Toxicology and Applied Pharmacology 2000; 168:140-148.

87. Huang Y.-T., Ghio AJ, Nozik-Grayck E, Piantadosi CA. Vascular release of nonheme iron in perfused rabbit lungs. American Journal of Physiology, Lung Cellular and Molecular Physiology 2001; 280 (3):L474-L481.

88. Brar SS, Kennedy TP, Whorton AR, Sturrock AB, Huecksteadt TP, Ghio AJ, Hoidal JR. Reactive oxygen species from NAD(P)H:quinone oxidoreductase constitutively activate NF-kappaB in malignanat melanoma cells. American Journal of Physiology, Cell Physiology 2001; 280 (3):C659-C676.

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89. Alexis N, Soukup J, Ghio A, Becker S. Sputum phagocytes from healthy individuals are functional and activated: A flow cytometric comparison with cells in bronchoalveolar lavage and peripheral blood. Clinical Immunology 2000; 97 (1): 21-32.

90. Wu W, Samet JM, Ghio AJ, Devlin RB. Activation of the EGF receptor signaling pathway in human airway epithelial cells exposed to Utah Valley particulate matter. American Journal of Physiology, Lung Cellular and Molecular Physiology 2001; 281:L483-L489.

91. Harder S, Soukup JM, Ghio AJ, Devlin RB, Becker S. Inhalation of PM2.5 does not modulate host defense or immune parameters in blood or lung of normal human subjects. Environmental Health Perspectives 2001; 109 (Supplement 4):599-604.

92. Ghio AJ, Roggli V, Light R. Letter to the editor: Talc should not be used for pleurodesis in patients with nonmalignant pleural effusions. American Journal of Respiratory and Critical Care Medicine 2001 Nov 1;164(9):1741.

93. Ghio AJ, Devlin RB. Inflammatory lung injury after instillation of humans with air pollution particles. American Journal of Respiratory and Critical Care Medicine 2001; Aug 15;164(4):704-8. Subject of editorial. Also, subject to additional commentary in; Zucker M. Steel mill particulates induce lung inflammation. Pulmonary Reviews 2001; 6 (11): 1.

94. Prahalad A, Inmon J, Dailey LA, Madden MC, Ghio AJ, Gallagher JE. Air Pollution Particles Mediated Oxidative DNA Base Damage in a Cell Free System and in Human Airway Epithelial Cells in Relation to Particulate Metal Content and Bioreactivity. Chemical Research in Toxicology 2001; 14(7):879-887.

95. Dye JA, Lehmann JR, McGee JK, Winsett DW, Ledbetter AD, Everitt JI, Ghio AJ, Costa DL. Acute pulmonary toxicity of particulate matter filter extracts in rats: coherence with epidemiologic studies in utah valley residents. Environmental Health Perspectives 2001; 109 (Supplement 3):395-403.

96. Ghio AJ, Gilbey JG, Roggli VL, Richards JH, McGee JK, Carson JL, Devlin DB, Cascio WE. Diffuse alveolar damage after exposure to an oil fly ash. American Journal of Respiratory and Critical Care Medicine 2001; Oct 15;164(8):1514-1518.

97. Welty-Wolf KE, Carraway MS, Miller DL, Ortel TL, Ezban M, Ghio AJ, Idell S, Piantadosi CA. Coagulation blockade prevents sepsis-induced respiratory and renal failure in baboons. American Journal of Respiratory and Critical Care Medicine 2001 Nov 15; 164(10):1988-1996.

98. Lay JC, Zeman KL, Ghio AJ, Bennett WD. Effects of inhaled iron oxide particles on alveolar epithelial permeability in normal subjects. Inhalation Toxicology 2001; Dec 13 (12):1065-1078.

99. Yang F, Haile DJ, Coalson JJ, Ghio AJ. Haptoglobin in lung defence. Redox Reports 2001; 6(6):372-4.

100.Huang YC, Wu W, Ghio AJ, Carter JD, Silbajoris R, Devlin RB, Samet JM. Activation of EGF receptors mediates pulmonary vasoconstriction induced by residual oil fly ash. Experimental Lung Research 2002 Jan-Feb; 28(1):19-38.

101.Ghio AJ, Silbajoris R, Carson JL, Samet JM. Biological effects of oil fly ash. Environmental Health Perspectives 2002; 110 (Supplement 1): 89-94.

102.Suliman HB, Carraway MS, Velsor LW, Day BJ, Ghio AJ, Piantadosi CA. Rapid mtDNA deletion by oxidants in rat liver mitochondria after hemin exposure. Free Radical Biology & Medicine 2002; 32 (3):246-256.

103.Carraway MS, Ghio AJ, Suliman HB, Carter JD, Whorton AR, Piantadosi CA. Carbon monoxide promotes hypoxic pulmonary vascular remodeling. American Journal of Physiology, Lung Cellular and Molecular Physiology 2002 April; 282 (4):L693-702.

104.Wang X, Ghio AJ, Yang F, Dolan KG, Garrick MD, Piantadosi CA. Iron uptake and Nramp-2/DMT1/DCT1in human bronchial epithelial cells. American Journal of Physiology, Lung

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Cellular and Molecular Physiology 2002; 282 (5): p. L987-L995.105.Ghio AJ, Suliman HB, Carter JD, Abushamaa AM, Folz RJ. Overexpression of extracellular

superoxide dismutase decreases lung injury after exposure to oil fly ash. American Journal of Physiology, Lung Cellular and Molecular Physiology 2002; 283 (1):L211-L218.

106.Alexis NE, Richards JH, Carter JD, Ghio AJ. Iron-binding and storage proteins in sputum. Inhalation Toxicology 2002; 14 (4): 387-400.

107.Miller DL, Welty-Wolf K, Carraway MS, Ezban M, Ghio A, Suliman H, Piantadosi CA. Extrinsic coagulation blockade attenuates lung injury and proinflammatory cytokine release after intratracheal lipopolysaccharide. American Journal of Respiratory Cell and Molecular Biology 2002; 26 (6):650-8.

108.Ghio AJ, Kennedy TP, Stonehuerner J, Carter JD, Skinner KA, Parks DA, Hoidal JR. Iron regulates xanthine oxidase activity in the lung. American Journal of Physiology, Lung Cellular and Molecular Physiology 2002; 283(3):L563-72.

109.Turi JL, Jaspers I, Dailey LA, Madden MC, Brighton LE, Carter JD, Nozik-Grayck E, Piantadosi CA, Ghio AJ. Oxidative stress activates anion exchange protein 2 and AP-1 in airway epithelial cells. American Journal of Physiology, Lung Cellular and Molecular Physiology 2002; 283 (4):L791-L798.

110.Molinelli AR, Madden MC, McGee JK, Stonehuerner JG, Ghio AJ. Effect of metal removal on the toxicity of airborne particulate matter from the Utah Valley. Inhalation Toxicology 2002; 14 (10):1069-1086.

111.Yang F, Liu XB, Quinones M, Melby PC, Ghio A, Haile DJ. Regulation of reticuloendothelial iron transporter MTP1 (Slc11a3) by inflammation. Journal of Biological Chemistry 2002; Oct 18; 277 (42): 39786-39791.

112.Yang F, Wang X, Haile DJ, Piantadosi CA, Ghio AJ. Iron increases expression of iron-export protein MTP1 in lung cells. American Journal of Physiology, Lung Cellular and Molecular Physiology 2002; Nov; 283(5): L932-939.

113.Sato K, Kadiiska MB, Ghio AJ, Corbett J, Fann YC, Holland SM, Thurman RG, Mason RP. In vivo lipid-derived free radical formation by NADPH oxidase in acute lung injury induced by lipopolysaccharide: a model for ARDS. FASEB J. 2002; 16 (13): 1713-1720.

114.Garrick MD, Dolan KG, Horbinski C, Ghio AJ, Higgins D, Porubcin M, Moore EG, Hainsworth LN, Umbreit JN, Conrad ME, Feng L, Lis A, Roth JA, Singleton S, Garrick LM. DMT1: a mammalian transporter for multiple metals. Biometals. 2003 Mar;16(1):41-54.

115.Yang F, Haile DJ, Berger FG, Herbert DC, Van Beveren E, Ghio AJ. Haptoglobin reduces lung injury associated with exposure to blood. Am J Physiol Lung Cell Mol Physiol. 2003 Feb;284(2):L402-9.

116.Ghio AJ, Carter JD, Richards JH, Richer LD, Grissom CK, Elstad MR. Iron and iron-related proteins in the lower respiratory tract of patients with acute respiratory distress syndrome. Crit Care Med 2003; Feb; 31(2):395-400.

117.Huang YC, Ghio AJ, Stonehuerner J, McGee J, Carter JD, Grambow SC, Devlin RB. The role of soluble components in ambient fine particles-induced changes in human lungs and blood. Inhal Toxicol 2003; 15(4):327-42.

118.Carraway MS, Welty-Wolf KE, Miller DL, Ortel TL, Idell S, Ghio AJ, Petersen LC, Piantadosi CA. Blockade of tissue factor: treatment for organ injury in established sepsis. American Journal of Respiratory and Critical Care Medicine 2003 May 1;167(9):1200-9.

119.Ghio AJ, Wang X, Silbajoris R, Garrick MD, Piantadosi CA, Yang F. DMT1 expression is increased in the lungs of hypotransferrinemic mice. American Journal of Physiology, Lung Cellular and Molecular Physiology 2003 Jun; 284 (6):L938-L944.

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120.Ghio AJ, Alexis N. Letter to the editor: Siderophages in sputum. Acta Cytologica 2003; 47 (4) (July/August): 695-696.

121.Devlin RB, Ghio AJ, Kehrl H, Sanders G, Cascio W. Elderly humans exposed to concentrated ambient air pollution particles have decreased heart rate variability. European Respiratory Journal 2003; 21 (Supplement 40):76s-80s.

122.Upadhyay D, Panduri V, Ghio A, Kamp DW. PM induces AEC DNA damage and apoptosis: role of free radicals and the mitochondria. Am J Respir Cell Mol Biol 2003 Aug;29(2):180-7.

123.Ghio AJ, Roggli VL, Richards JH, Crissman KM, Stonehuerner JD, Piantadosi CA. Oxalate deposition on asbestos bodies. Human Pathology 2003; 34:737-42. Subject of editorial. Cover picture.

124.Wu W, Wang X, Whang YE, Zhang W, Reed W, Samet JM, Ghio AJ. Induction of PTEN degradation in human airway epithelial cells exposed to zinc. Journal of Biological Chemistry 2003 Jul 25; 278 (30):28258-63.

125.Ghio AJ, Nozik-Grayck E, Turi J, Jaspers I, Mercatante DR, Kole R, Piantadosi CA. Superoxide-dependent iron uptake: A new role for anion exchange protein Am J Respir Cell Mol Biol 2003; 29:653-60.

126.Ghio AJ, Hall A, Bassett MA, Cascio WE, Devlin RB. Exposure to Concentrated Ambient Air Particles Alters Hematologic Indices in Humans. Inhal Toxicol 2003; 15:1465-1478.

127.Ghio AJ, Huang YC. Exposure to Concentrated Ambient Particles (CAPs): A Review. Inhal Toxicol 2004; 16: 53-9.

128.Ghio AJ. Biological effects of Utah Valley air pollution particles: A review. Journal of Aerosol Medicine 2004; 17 (2):157-164.

129.Kadiiska MB, Ghio AJ, Mason RP. ESR investigation of the oxidative damage in lungs caused by asbestos and air pollution particles. Spectrochim Acta A Mol Biomol Spectrosc. 2004; 60 (6):1371-7.

130.Turi JL, Yang F, Garrick MD, Piantadosi CA, Ghio AJ. The iron cycle and oxidative stress in the lung. Free Radic Biol Med 2004; 36 (7):850-7.

131.Brar SS, Grigg C, Wilson KS, Holder WD, Dreau D, Austin C, Foster M, Ghio AJ, Whorton AR, Stowell GW, Whittall LB, Whittle DP, White D, Kennedy TP. Disulfiram inhibits ATF/CREB and human melanoma growth in a metal-dependent manner in vitro, in mine and in a patient with metastatic disease. Molecular Cancer Therapeutics 2004; 3 (9): 1049-1060.

132.Ghio AJ, Churg A, Roggli VL. Ferruginous bodies: Implications in the mechanism of fiber and particle toxicity. Toxicologic Pathology 2004; 32:643-649.

133.Wang X, Wu Y, Li Z, Samet JM, Ghio AJ. Activation of ERK1/2 and Elk1 in A549 cells induced by crocidolite. Wei Sheng Yan Jiu 2004; 33:398-9.

134.Ghio AJ, Roggli VL. Letter to the editor: Diagnosis and initial management of nonmalignant diseases related to asbestos. American Journal of Respiratory and Critical Care Medicine 2005 Mar 1;171(5):527.

135.Ghio AJ, Ford ES, Kennedy TP, Hoidal JR. The association between serum ferritin and uric acid in humans. Free Radical Research 2005 Mar; 39(3):337-42. Corrigendum included- Free Radical Research 2007; 41 (12): 1385.

136.Ghio AJ, Lehmann JR, Winsett DW, Richards JH, Costa DL. Colchicine decreases airway hyperreactivity after phosgene exposure. Inhalation Toxicology 2005 May; 17 (6):277-285.

137.Erpenbeck VJ, Malherbe DC, Sommer S, Steinhilber W, Ghio AJ, Krug N, Wright JR, Hohlfeld JM. Surfactant protein D increases the uptake of allergen-containing pollen starch granules by alveolar macrophages. Am J Physiol Lung Cell Mol Physiol. 2005 Apr;288(4):L692-8.

138.Beck-Speier I, Dayal N, Karg E, Maier KL, Schumann G, Schulz H, Semmler M, Takenaka S,

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Stettmaier K, Bors W, Ghio A, Samet JM, Heyder J. Oxidative stress and lipid mediators induced in alveolar macrophages by ultrafine particles. Free Radical Biology & Medicine 2005; 38:1080-1092. Commentary focused on this article: Mossman BT, Shukla A, Fukagawa NK. Highlight Commentary on "Oxidative stress and lipid mediators induced in alveolar macrophages by ultrafine particles". Free Radic Biol Med 2005; 38:1080-92.

139.Wang X, Garrick MD, Yang F, Dailey LA, Piantadosi CA, Ghio AJ. TNF, IFN-δ, and endotoxin increase expression of DMT1 in bronchial epithelial cells. American Journal of Physiology 2005; 289:L24-L33.

140.Yang F, Haile DJ, Wang X, Dailey LA, Ghio AJ. Apical location of ferroportin 1 in airway epithelia and its role in iron detoxification in the lung. American Journal of Physiology 2005; 289:L14-L23.

141.Pugh C, Hathwar V, Richards JH, Stonehuerner J, Ghio AJ. Disruption of iron homeostasis in the lungs of transplant patients. Journal of Heart and Lung Transplantation 2005; 24 (11):1821-1827.

142.Anseth JW, Goffin AJ, Fuller GG, Ghio AJ, Kao PN, Upadhyay D. Lung surfactant gelation induced by epithelial cells exposed to air pollution or oxidative stress. American Journal of Respiratory Cell and Molecular Biology 2005; 33 (2):161-168.

143.Ghio AJ, Cohen MD. Disruption of iron homeostasis as a mechanism of biologic effect by ambient air pollution particles. Inhalation Toxicology 2005; 17 (13):709-716.

144.Ghio AJ, Piantadosi CA, Wang X, Dailey LA, Stonehuerner JD, Madden MC, Yang F, Dolan KG, Garrick LM, Garrick MD. DMT1 decreases metal-related injury in the lung. American Journal of Physiology 2005; 289:L460-467. Subject of news release by the American Physiological Society.

145.Wang XC, Xu YB, Wu YM, Li ZW, Samet JM, Ghio AJ. Study of IL-8 overexpression in A549 cells induced by crocidolite fibers. Wei Sheng Yan Jiu 2005; 34:141-143.

146.Devlin RB, Frampton ML, Ghio AJ. In vitro studies: what is their role in toxicology? Experimental and Toxicologic Pathology 2005; 57:183-188.

147.Welty-Wolf KE, Carraway MS, Ortel TL, Ghio AJ, Idell S, Egan J, Zhu X, Jiao J, Wong HC, Piantadosi CA. Blockade of tissue factor-factor X binding attenuates sepsis-induced respiratory and renal failure. American Journal of Physiology 2005; 290 (1):L21-L31.

148.Warheit DB, Reed KL, Stonehuerner JD, Ghio AJ, Webb TR. Biodegradability of para-aramid respirable-sized fiber-shaped particulates (RFP) in human lung cells. Toxicologic Sciences 2006; 89 (1): 296-303.

149.Roggli VL, Ghio AJ, Piantadosi CA, MacIntyre NR, Young SL, Kussin PS, Steele MP, Carraway MS, Welty-Wolf KE, Govert JA, McMahon TJ, Palmer SM, Sporn TA. Physician subsidies for tobacco adertising. American Journal of Respiratory and Critical Care Medicine 2006; 173 (2):246.

150.Mutlu GM, Snyder C, Bellmeyer A, Wang H, Hawkins K, Soberanes S, Welch LC, Ghio AJ, Chandel NS, Kamp D, Sznajder JI, Budinger GRS. Airborne particulate matter inhibits alveolar fluid reabsorption in mice via oxidant generation. American Journal of Respiratory Cell and Molecular Biology 2006; 34 (6):670-676.

151.Huang YCT, Ghio AJ. Vascular effects of ambient pollutant particles and metals. Current Vascular Pharmacology 2006; 4:199-203.

152.Wang X, Wu Y, Stonehuerner JD, Dailey LA, Richards JD, Jaspers I, Piantadosi CA, Ghio AJ. Oxidant generation promotes iron sequestration in BEAS-2B cells exposed to asbestos. American Journal of Respiratory Cell and Molecular Biology 2006; 34:286-292.

153.Ghio AJ, Turi JL, Yang F, Garrick LM, Garrick MD. Iron homeostasis in the lung. Biological Research 2006; 39 (1): 67-77.

154.Huang, Y-C T, Bassett MA, Levin D, Montilla T, Ghio AJ. Acute phase reaction in healthy volunteers after bronchoscopy with lavage. Chest 2006; 129:1565-1569.

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155.Turi JL, Wang X, Nozik-Grayck E, McKie AT, Piantadosi CA, Ghio AJ. The role of duodenal cytochrome b in the iron cycle of the lung. American Journal of Physiology 2006; 291 (2):L272-80.

156.Nguyen N-B, Callaghan KD, Ghio AJ, Haile DJ, Yang F. Hepcidin expression and iron transport in alveolar macrophages. American Journal of Physiology 2006; 291 (3):L417-L425.

157.McCaskill JG, Chason KD, Hua X, Neuringer IP, Ghio AJ, Funkhouser WK, Tilley SL. Pulmonary immune responses to Propionibacterium acnes in C57BL/6 and BALB/c mice. American Journal of Respiratory Cell and Molecular Biology 2006; 35(3):347-56.

158.Ghio AJ, Mazan MR, Hoffmann AM, Robinson NE. Correlates between human and equine lung injury after particle exposure. Equine Veterinary Journal 2006; 38 (4):362-367.

159.Wang X, Samet JM, Ghio AJ. Asbestos-induced activation of cell signaling pathways in human bronchial epithelial cells. Experimental Lung Research 2006; 32 (6):229-243.

160.Jang M, Ghio AJ, Cao G. Exposure of BEAS-2B cells to secondary organic aerosol coated on magnetic nanoparticles. Chemical Research in Toxicology 2006; 19 (8):1044-1050.

161.Schmechel DE, Browndyke J, Ghio A. Strategies for the dissection of genetic-environmental interactions in neurodegenerative disorders. Neurotoxicology 2006; 27 (5):637-657.

162.Ghio AJ, Funkhouser W, Pugh CB, Winters S, Stonehuerner JG, Mahar AM, Roggli VL. Pulmonary fibrosis and ferruginous bodies in a textile worker exposed to synthetic fibers. Toxicologic Pathology 2006; 24 (6):723-729.

163.Ghio AJ, Ghio C, Bassett M. Exercise-induced pulmonary hemorrhage after running a marathon. Lung 2006; 184 (6):331-333.

164.Soberanes S, Panduri V, Mutlu GM, Ghio A, Budinger GR, Kamp DW. P53 mediates particulate matter-induced alveolar epithelial cell mitochondrial dysfunction and apoptosis. American Journal of Respiratory and Critical Care Medicine 2006; 174 (11):1229-1238.

165.Carraway MS, Suliman HB, Madden MC, Piantadosi CA, Ghio AJ. Metabolic capacity regulates iron homeostasis in endothelial cells. Free Radical Biology & Medicine 2006; 41(11):1662-9.

166.Kennedy MP, Noone PG, Carson J, Molina PL, Ghio A, Zariwala MA, Minnix SL, Knowles MR. Calcium stone lithoptysis in primary ciliary dyskinesia. Respiratory Medicine 2007; 101 (1):76-83.

167.Wang XC, Wu YM, Samet JM, Ghio AJ. Expression of phosphorylated ERK1/2 induced by crocidolite fibers in BEAS-2B cells. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2006 Oct; 24(10):597-600.

168.Benedict C, Ghio AJ, Gehring H, Schultes B, Peters A, Oltmanns KM. Transient hypoxia and downregulation of circulating prohepcidin concentrations in healthy young men. Haematologica 2007; 92:125-126.

169.Ghio AJ, Turi JL, Madden MC, Dailey LA, Richards JD, Stonehuerner JG, Morgan DL, Garrick LM, and Garrick MD. Lung injury after ozone exposure is iron-dependent. American Journal of Physiology 2007; 292(1):L134-43.

170.Bolger MS, Ross DS, Jiang H, Frank MM, Ghio AJ, Schwartz DA, Wright JR. Complement levels and activity in the normal and LPS-injured lung. American Journal of Physiology 2007; 292 (3):L748-L59.

171.Ghio AJ, Bennett WD. Metal particles are inappropriate for testing a postulate of extra-pulmonary transport. Environmental Health Perspectives 2007; 115 (2): A70.

172.Cohen MD, Sisco M, Prophete C, Chen L-C, Zelikoff JT, Smee JJ, Holder AA, Ghio AJ, Stonehuerner JD, Crans DC. Pulmonary immunotoxic potentials of metals are governed by select physicochemical properties: vanadium agents. Journal of Immunotoxicology 2007; 4:49-60.

173.Ghio AJ, Bassett MA, Levin D, Montilla T. Oxygen supplementation is required in healthy volunteers during bronchoscopy with lavage. Journal of Bronchology 2007; 14 (1):19-21.

174.Swanson K, Madden MC, Ghio AJ. Biodiesel exhaust: the need for human health effects research.

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Environmental Health Perspectives 2007; 115 (4):496-499.175.Zheng S, Byrd AS, Fischer BM, Grover AR, Ghio AJ, Voynow JA. Regulation of MUC5AC

expression by NAD(P)H:quinone oxidoreductase 1. Free Radical Biology & Medicine 2007; 42 (9):1398-1408.

176.Samet JM, Graff D, Berntsen J, Ghio AJ, Huang T, Devlin RB. A comparison of studies on the effects of controlled exposure to fine, coarse and ultrafine ambient particulate matter from a single location. Inhalation Toxicology 2007; 19 (Supple 1): 29-32.

177.Zhang J, Ghio AJ, Chang W, Kamdar O, Rosen GD, Upadhyay D. Bim mediates mitochondria-regulated particulate matter-induced apoptosis in alveolar epithelial cells. FEBS Lett 2007; 581:4148-52.

178.Mutlu GM, Green D, Bellmeyer A, Baker CM, Burgess Z, Rajamannan N, Christman JW, Foiles N, Kamp DW, Ghio AJ, Chandel NS, Dean DA, Sznajder JI, Budinger GRS. Ambient particulate matter accelerates coagulation via an IL-6 dependent pathway. Journal of Clinical Investigation 2007; 117(10):2952-2961.

179.Zhang J, Ghio AJ, Gao M, Wei K, Rosen GD, Upadhyay D. Ambient particulate matter induces alveolar epithelial cell cycle arrest: Role of G1 cyclins. FEBS Lett 2007; 581:5315-20.

180.Brown JS, Graham JA, Chen LC, Postlethwait EM, Ghio AJ, Foster WM, Gordon T. Panel discussion review: session four--assessing biological plausibility of epidemiological findings in air pollution research. Journal of Exposure Science and Environmental Epidemiology 2007; 17 (Supplement 2): S97-S105.

181.Ghio AJ, Stonehuerner J, Richards J, Devlin RB. Iron homeostasis in the lung following asbestos exposure. Antioxidants & Redox Signaling 2008; 10(2): 371-378.

182.Sint T, Donohue JF, Ghio AJ. Ambient air pollution particles and the acute exacerbation of chronic obstructive pulmonary disease. Inhalation Toxicology 2008; 20(1):25-9.

183.Ayres JG, Borm P, Cassee FR, Castranova V, Donaldson K, Ghio A, Harrison RM, Hider R, Kelly F, Kooter IM, Marano F, Maynard RL, Mudway I, Nel A, Sioutas C, Smith S, Baeza-Squiban A, Cho A, Duggan S, Froines J. Evaluating the toxicity of airborne particulate matter and nanoparticles by measuring oxidative stress potential--a workshop report and consensus statement. Inhal Toxicol 2008; 20 (1):75-99.

184.Ghio AJ. Mechanism of asthmatic exacerbation by ambient air pollution particles. Expert Review of Respiratory Medicine 2008; 2 (1):109-118.

185.Ghio AJ, Stonehuerner J, Richards JH, Crissman K, Roggli VL, Piantadosi CA, Carraway MS. Iron homeostasis in the lungs of patients with pulmonary alveolar proteinosis: a case-control study. Respir Res 2008 Jan 23; 9:10.

186.Ghio AJ, Stonehuerner JG, Dailey LA, Richards JH, Madden MD, Deng Z, Nguyen NB, Callaghan KD, Yang F, Piantadosi CA. Carbon Monoxide Reversibly Alters Iron Homeostasis and Respiratory Epithelial Cell Function. American Journal of Respiratory Cell Molecular Biology 2008; 38 (6):715-723

187.Turi JL, Piantadosi CA, Stonehuerner JD, Ghio AJ. Iron transport in bronchial epithelial cells is dependent on concurrent sodium transport. Biometals, 2008; 21 (5):571-580.

188.Sawyer K, Samet JM, Ghio AJ, Pleil JD, Madden MC. Responses measured in the exhaled breath of human volunteers acutely exposed to ozone and diesel exhaust. Journal of Breath Research 2008; 2:1-9.

189.Cohen MD, Sisco M, Prophete C, Chen LC, Zelikoff JT, Ghio AJ, Stonehuerner JD, Smee JJ, Holder AA, Crans DC. Pulmonary immunotoxic potentials of metals are governed by select physicochemical properties: vanadium agents. J Immunotoxicol 2008; 4:49-60.

190.Kamdar O, Le W, Zhang J, Ghio AJ, Rosen GD, Upadhyay D. Air pollution induces enhanced

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mitochondrial oxidative stress in cystic fibrosis airway epithelium. FEBS Letters 2008; 582(25-26): 3601-3606.

191.Ghio AJ, Hilborn ED, Stonehuerner JG, Dailey LA, Carter JD, Richards JH, Crissman KM, Foronjy RF, Uyeminami DL, Pinkerton KE. Particulate matter in cigarette smoke alters iron homeostasis producing an oxidative stress and inflammation. American Journal of Respiratory and Critical Care Medicine 2008; 178 (11):1130-1138.

192.Ghio AJ, Jang M. Acid and organic aerosol coatings on magnetic nanoparticles increase iron concentrations in human airway epithelial cells. Inhalation Toxicology 2009; 21 (8):659-667.

193.Li J, Ghio A, Cho S-H, Brinckerhoff C, Simon SA, Liedtke W. Diesel-exhaust particles activate the matrix-metalloproteinase-1 gene in human bronchial epithelia in a β-arrestin-manner via activation of RAS. Environmental Health Perspectives 2009; 117:400-409. Focus of article in International Business Times (12/10/2008).

194.Fischer BM, Zheng S, Potts EN, Grover AR, Savov JD, Jaiswal AK, Ghio AJ, Foster WM, Voynow JA. NADPH quinone oxidoreductase 1 (NQO1) links ozone-induced oxidative stress and acute airway inflammation. American Journal of Respiratory Cell and Molecular Biology 2009; 41 (1):107-113.

195.Soberanes S, Urich D, Kwon JS, Baker CM, Burgess ZO, Chiarella SE, Bell1 EL, Ghio AJ, Ridge KM, Kamp DW, Chandel1 NS, Schumacker PT, Mutlu GM, Budinger GRS. Mitochondrial complex III generated oxidants activate ASK1 and JNK to induce alveolar epithelial cell death following exposure to particulate matter air pollution. Journal of Biological Chemistry 2009; 284:2176-2186.

196.Connor JR, Ghio AJ. The impact of host iron homeostasis on disease. Biochimica et Biophysica Acta General Subjects 2009; 1740: 581-582.

197.Ghio AJ. Disruption of iron homeostasis and lung disease. Biochimica et Biophysica Acta General Subjects 2009; 1740: 731-739.

198.Kaczmarek M, CachauR, Topol IA, Kasprzak KS, Ghio A, Salnikow K. Iron oxidation in hydroxylases accounts for activation of HIF-1 proteins by metal ions. Toxicological Sciences 2009; 107:394-403.

199.Swanson KJ,. Kado NY, Funk WE, Pleil JD, Madden MC, Ghio AJ. Release of the Pro-Inflammatory Markers by BEAS-2B Cells Following In Vitro Exposure to Biodiesel Extracts. Open Toxicology Journal 2009; 3: 8-15.

200.Silbajoris R, Huang JM, Cheng W-Y, Dailey L, Tal TL, Jaspers I, Ghio AJ, Bromberg PA, Samet JM. Nanodiamond particles induce IL-8 expression through a transcript stabilization mechanism in human airway epithelial cells. Nanotoxicology 2009; 3(2): 152-160.

201.Mazan MR, Svatek J, Maranda L, Christiani D, Ghio A, Nadeau J, Hoffman AM. Questionnaire assessment of airway disease symptoms in equine barn personnel. Occup Med (Lond) 2009 Jun; 59(4):220-5.

202.Esther Jr CR, Boysen G, Olsen BM, Collins LB, Ghio AJ, Swenberg JW, Boucher RC. Mass Spectrometric Analysis of Biomarkers and Dilution Markers in Exhaled Breath Condensate Reveals Elevated Purines in Asthma and Cystic Fibrosis. Am J Physiol Lung Cell Mol Physiol 2009; 296(6):L987-93.

203.Urich D, Soberanes S, Baker CM, Burgess Z, Chiarella S, Fakhran S, Ghio AJ, Ridge KM, Green D, Kamp DW, Sznajder JI, Chandell NS, Mutlu GM, Budinger GRS. Proapoptotic NOXA is required for particulate matter-induced cell death and lung injury. FASEB Journal 2009; 23(7):2055-2064

204.Deng Z, Dailey LA, Soukup J, Stonehuerner J, Richards JD, Callaghan KD, Yang F, Ghio AJ. Zinc transport by respiratory epithelial cells and interaction with iron homeostasis. Biometals 2009; 22

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(5):803-15.205.Ghio AJ, Tan RJ, Ghio K, Fattman CL, Oury TD. Iron accumulation and expression of iron-related

proteins following in vivo exposure to crocidolite. Journal of Environmental Pathology, Toxicology and Oncology 2009; 28 (2): 153-162.

206.Sawyer K, Ghio AJ, Madden, MC. The Effect of Ambient Particulate Matter on Human Alveolar Macrophage Oxidative and Inflammatory Responses. J Toxicol Environ Health A 2010; 73 (1):41-57.

207.Huang YCT, Ghio AJ. Controlled human exposures to ambient pollutant particles in susceptible populations. Environmental Health 2009; 8:33.

208.Baker JF, Ghio AJ. Iron homeostasis in autoimmune diseases and gout. Rheumatology 2009; 48 (11):1339-1144.

209.Cohen MD, Sisco M, Prophete C, Yoshida K, Chen LC, Zelikoff JT, Smee J, Holder AA, Stonehuerner J, Crans DC, Ghio AJ.. Effects of metal compounds with distinct physicochemical properties on iron homeostasis and antibacterial activity in the lungs: chromium and vanadium. Inhalation Toxicology 2010; 22 (2):169-178.

210.Fischer BM, Lopez Domowicz DA, Zheng S, Carter JL, McElvaney NG, Taggert C, Lehmann JR, Voynow JA, Ghio AJ. Neutrophil Elastase Increases Airway Epithelial Non-Heme Iron Levels. Clinical and Translational Science 2009; 2 (5):333-339.

211.Ghio AJ, Sangani RG, Brighton LE, Carson JL. MRT Letter: Ambient air pollution particles and autofluorescence by human alveolar macrophages. Microscopy Research and Technique 2010; 73 (6): 579-582.

212.D'Armiento JM, Scharf SM, Roth MD, Connett JE, Ghio A, Sternberg D, Goldin JG, Louis TA, Mao JT, O'Connor GT, Ramsdell JW, Ries AL, Schluger NW, Sciurba FC, Skeans MA, Voelker H, Walter RE, Wendt CH, Weinmann GG, Wise RA, Foronjy RF. Eosinophil and T cell Markers Predict Functional Decline in COPD Patients. Respiratory Research 2009 Nov 19; 10 (1): 113.

213.Sangani RG, Soukup JM, Ghio AJ. Metals in air pollution particles decrease whole blood coagulation time. Inhalation Toxicology 2010; 22 (8):621-626.

214.Antonini JM, Roberts JR, Chapman R, Soukup JM, Ghio AJ, Sriram K. Pulmonary Toxicity and Extrapulmonary Tissue Distribution of Metals after Repeated Exposure to Different Welding Fumes. Inhalation Toxicology 2010; 22 (10): 805–816.

215.McIntosh R, Lee S, Ghio AJ, Xi J, Zhu M, Shen X, Chanoit G, Zvara DA, Xu Z. Intracellular zinc mediates adenosine A2 receptor activation induced cardioprotection against reperfusion injury. Journal of Molecular and Cellular Cardiology 2010; 49 (1):41-47.

216.Sriram K, Lin GX, Jeffferson AM, Roberts JR, Chapman RS, Soukup JM, Ghio AJ, Antonini JM. Dopaminergic neurotoxicity following pulmonary exposure to manganese-containing welding fumes. Archives of Toxicology 2010; 84 (7):521-540.

217.Yang F, Stonehuerner J, Richards JH, Nguyen N-B, Callaghan KD, Haile DJ, Ghio AJ. Deficiency in the divalent metal transporter 1 augments bleomycin-induced lung injury. Biometals 2010; 23 (4):657-667.

218.Mackenzie B, Shawki A, Ghio AJ, Stonehuerner JD, Zhao L, Ghadersohi S, Garrick LM, Garrick MD. A role for divalent metal-ion transporter-1 is doubtful in the mechanism by which calcium-channel blockers reverse iron overload. Blood 2010; 115(20): 4148-4149.

219. Farraj AK, Hazari MS, Haykal-Coates N, Lamb C, Winsett DW, Ge Y, Ledbetter AD, Carll AP, Bruno M, Ghio A, Costa DL. ST depression, Arrhythmia, Vagal Dominance, and Reduced Cardiac MicroRNA in Particulate-exposed Rats. American Journal of Respiratory Cell and Molecular Biology 2011; 44 (2):185-96.

220.Shannahan JH, Schladweiler MC, Richards JH, Ledbetter AD, Ghio AJ, Kodavanti UP. Pulmonary

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oxidative stress, inflammation, and dysregulated iron homeostasis in rat models of cardiovascular disease. J Toxicol Environ Health A 2010; 73 (10):641-56.

221.Pleil JD, Stiegel MA, Sobus JR, Tabucchi S, Ghio AJ, Madden MC. Cumulative exposure assessment for trace-level polycyclic aromatic hydrocarbons (PAHs) using human blood and plasma analysis. J Chromatogr B Analyt Technol Biomed Life Sci. 2010; 878 (21):1753-1760.

222.Wang S, Prophete C, Soukup JM, Chen LC, Costa M, Ghio A, Qu Q, Cohen MD, Chen H. Roles of MAPK Pathway Activation During Cytokine Induction in BEAS-2B Cells Exposed to Fine World Trade Center (WTC) Dust. Journal of Immunotoxicology 2010; 7 (4):298-307.

223.Sriram K, Lin GX, Jefferson AM, Roberts JR, Wirth O, Hayashi Y, Krajnak KM, Soukup JM, Ghio AJ, Reynolds SH, Castranova V, Munson AE, Antonini JM. Mitochondrial dysfunction and loss of Parkinson's disease-linked proteins contribute to neurotoxicity of manganese-containing welding fumes. FASEB J 2010; 24: 4989-5002.

224.Duncan KE, Ghio AJ, Dailey LA, Bern AM, Gibbs-Flournoy EA, Padilla-Carlin DJ, Roggli VL, Devlin RB. Effect of Size-Fractionation on the Toxicity of Amosite and Libby Asbestos. Toxicological Science 2010; 118:420-434.

225.Sangani RG, Ghio AJ. Lung injury after cigarette smoking is particle-related. International Journal of Chronic Obstructive Pulmonary Disease 2011; 6:191-198.

226.Shannahan JH, Schladweiler MCJ, Padilla-Carlin DJ, Nyska A, Richards JH, Ghio AJ, Gavett SH, Kodavanti UP. Acute Pulmonary Inflammation and Injury in Rat Models of Cardiovascular Disease after Exposure to Libby Amphibole. Inhalation Toxicology 2011; 23(3):129-141.

227.Ghio AJ, Soukup JM, Dailey LA, Richards J, Deng Z, Abraham JL. Gadolinium exposure disrupts iron homeostasis in cultured cells. Journal of Biological Inorganic Chemistry 2011; 16 (4):567-575.

228.Li J, Kanju P, Patterson M, Chew W-L, Cho S-H, Gilmour I, Oliver T, Yasuda R, Ghio A, Simon SA, Liedtke W. TRPV4-Mediated Calcium-influx into Human Bronchial Epithelia upon Exposure to Diesel Exhaust Particles. Environmental Health Perspectives 2011; 119 (6):784-793.

229.Shannahan JH, Ghio AJ, Schladweiler MCJ, McGee JK, Richards JH, Gavett SH, Kodavanti UP. The Role of Iron in Libby Amphibole-Induced Toxicity In Vitro and In Vivo. Inhalation Toxicology 2011; 23 (6): 313-323.

230.Budinger GR, McKell JL, Urich D, Foiles N, Weiss I, Chiarella SE, Gonzalez A, Soberanes S, Ghio AJ, Nigdelioglu R, Mutlu EA, Radigan KA, Green D, Kwaan HC, Mutlu GM. Particulate Matter-Induced Lung Inflammation Increases Systemic Levels of PAI-1 and Activates Coagulation Through Distinct Mechanisms. PLoS One 2011; 6 (4): e18525.

231. Ghio AJ, Soukup JM, Case M, Dailey LA, Richards J, Berntsen J, Devlin RB, Stone S, Rappold A. Exposure to wood smoke particles produces an inflammation in healthy volunteers. Occupational and Environmental Medicine 2012;69:170-175.

232.Ghio AJ, Carraway MS, Madden MC. Composition of air pollution particles and oxidative stress in cells, tissues, and living systems. Journal of Toxicology and Environmental Health, Part B, 15:1–21, 2012.

233. Shannahan JH, Nyska A, Cesta M, Schladwiler MCJ, Vallant BD, Ward WO, Ghio AJ, Gavett SH, Kodavanti UP. Subchronic pulmonary pathology, iron-overload and transcriptional activity after Libby amphibole exposure in rat models of cardiovascular disease. Environmental Health Perspectives 2011; 120 (1):85-91.

234.Frazier MD, Mamo LB, Ghio AJ, Turi JL. IFN-γ regulates expression of hepcidin in airway epithelial cells. Respiratory Research 2011; 12:100.

235.Ghio AJ, Soukup JM, Dailey LA, Richards JH, Turi JL, Pavlisko EN, Roggli VL. Disruption of iron homeostasis in mesothelial cells following talc pleurodesis. American Journal of Respiratory Cell and Molecular Biology 2012;46 80-86.

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236.Ghio AJ, Bassett MA, Montilla T, Chung EH, Smith CB, Cascio WE, Carraway MS. Case report: Supraventricular Arrhythmia Following Exposure to concentrated Ambient Air Pollution Particles. Environmental Health Perspectives 2012; 120 (2): 275-277.

237.Ghio AJ. Letter to the editor: Anemia and global iron fortification and supplementation. Annals of Hematology 2012; 91:957–958.

238.Bayram H, Ghio AJ. Killer jeans and silicosis. American Journal of Respiratory and Critical Care Medicine 2011 Dec 15;184(12):1322-1324. Accompanied by an American Thoracic Society PODCAST interview in December, 2011.

239. Ghio AJ, Weinberg ED. Complications of TNF-α antagonists and iron homeostasis. Medical Hypotheses 2012; 78: 33–35.

240.Shannahan JH, Ghio AJ, Schladweiler MC, Richards JH, Knapp G, Andrews D, Gavett SH, Kodavanti UP. Transcriptional activation of inflammasome components by Libby amphibole and the role of iron. Inhalation Toxicology 2012; 24 (1): 60-69.

241.Ghio AJ. Letter to the editor: Effects of particulate matter from global burning of biomass. British Medical Journal 2011; 343:d7307.

242.Ghio AJ, Smith CB, Madden MC. Diesel exhaust particles and airway inflammation. Current Opinion in Pulmonary Medicine 2011; 18 (2): 144-150.

243.Shannahan JH, Schladweiler MC, Thomas RF, Ward WO, Ghio AJ, Gavett SH, Kodavanti UP. Vascular and thrombogenic effects of pulmonary exposure to libby amphibole. J Toxicol Environ Health A 2012; 75:213-31.

244.Shannahan JH, Alzate O, Winnik WM, Andrews D, Schladweiler MC, Ghio AJ, Gavett SH, Kodavanti UP. Acute phase response, inflammation and metabolic syndrome biomarkers of Libby asbestos exposure. Toxicology and Applied Pharmacology 2012; 260(2):105-14.

245.Piantadosi CA, Bartz RR, Carraway MS, Ghio AJ, McMahon TJ, Murdoch DM, Roggli VL, Shofer SL, Tighe RM, Welty-Wolf KE, Young SL. Letter to the editor: The opprobrium of big tobacco. American Journal of Respiratory Critical Care Medicine 2012; 185(9):1030.

246.Ghio AJ, Sobus JR, Pleil JD, Madden MC. Controlled human exposures to diesel exhaust. Swiss Med Wkly. 2012; 142:w13597. doi: 10.4414/smw.2012.13597.

247.Meyer M, Potts-Kant E, Ghio A, Fischer B, Foster W, Voynow J. NAD(P)H quinone oxidoreductase 1 regulates neutrophil elastase-induced mucous cell metaplasia. American Journal of Physiology, Lung Cellular and Molecular Physiology 2012 Aug 1;303(3):L181-188.

248. Ozment CP, Mamo LB, Campbell ML, Lokhnygina Y, Ghio AJ, Turi JL. Transfusion-related biologic effects and free hemoglobin, heme, and iron. Transfusion 2013 Apr;53 (4):732-40. doi: 10.1111/j.1537-2995.2012.03837.x.

249. Fares WH, Ford HJ, Ghio AJ, Aris RM. Differential Distribution of Inflammatory and Cellular Adhesion Biomarkers in Pulmonary Hypertension. Pulmonary Circulation 2012; 2 (4): 477-482.

250. Roth JA, Ganapathy B, Ghio AJ. Manganese-Induced Toxicity in Normal and Human B Lymphocyte Cell Lines Containing a Homozygous Mutation in Parkin. Toxicol In Vitro 2012; Oct;26(7):1143-9.

251. Huang YC, Rappold AG, Graff DW, Ghio AJ, Devlin RB. Synergistic effects of exposure to concentrated ambient fine pollution particles and nitrogen dioxide in humans. Inhal Toxicol 2012; 24(12):790-7.

252. Funk WE, McGee JK, Olshan AF, Ghio AJ. Quantification of arsenic, lead, mercury and cadmium in newborn dried blood spots. Biomarkers 2013; 18(2):174-177.

253. Ghio AJ, Roggli VL, Soukup JM, Richards JH, Randell SH, Muhlebach MS. Iron accumulates in the lavage and explanted lungs of cystic fibrosis patients. J Cyst Fibros 2013; 12: 390-8. doi: 10.1016/j.jcf.2012.10.010

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254. Kummarapurugu AB, Fischer BM, Zheng S, Milne GL, Ghio AJ, Potts-Kant EN, Foster WM, Soderblom EJ, Dubois LG, Moseley MA, Thompson JW, Voynow JA. NADPH Quinone Oxidoreductase 1 Regulates Host Susceptibility to Ozone via Isoprostane Generation. J Biol Chem. 2013; 288(7):4681-4691.

255. Fariss MW, Gilmour IM, Reilly CA, Liedtke W, Ghio AJ. Emerging Mechanistic Targets in Lung Injury Induced by Combustion-Generated Particles. Toxicol Sci. 2013; 132 (2):253-67. Cover picture.

256. Ghio AJ, Soukup JM, Richards JH, Fischer BM, Voynow JA, Schmechel DE. Deficiency of α -1-antitrypsin influences systemic iron homeostasis. International Journal of COPD 2013; 8: 45–51.

257. D'Armiento JM, Goldklang MP, Hardigan AA, Geraghty P, Roth MD, Connett JE, Wise RA, Sciurba FC, Scharf SM, Thankachen J, Islam M, Ghio AJ, Foronjy RF. Increased Matrix Metalloproteinase (MMPs) Levels Do Not Predict Disease Severity or Progression in Emphysema. PLoS One 2013;8(2):e56352. doi: 10.1371/journal.pone.0056352.

258. Ghio AJ, Dailey LA, Soukup JM, Stonehuerner J, Richards JH, Devlin RB. Growth of human bronchial epithelial cells at an air-liquid interface alters the response to particle exposure. Part Fibre Toxicol. 2013 Jun 26; 10(1): 25. Reviewed in Pulmonary Cell News 2.26 July 4, 2013.

259. Ghio AJ. Letter to the Editor: Inhalation as a source of iron in secondary iron overload. Acta Haematol 2014; 131(1):70. doi: 10.1159/000354822.

260. Esther CR Jr, Boucher RC, Johnson MR, Ansede JH, Donn KH, O'Riordan TG, Ghio AJ, Hirsh AJ. Airway drug pharmacokinetics via analysis of exhaled breath condensate. Pulm Pharmacol Ther 2013; S1094-5539(13)00149-1.

261. Ghio AJ, Tong H, Soukup JM, Dailey LA, Cheng WY, Samet JM, Kesic MJ, Bromberg PA, Turi JL, Upadhyay D, Budinger GS, Mutlu GM. Sequestration of mitochondrial iron by silica particle initiates a biological effect. Am J Physiol Lung Cell Mol Physiol 2013; 201; 305(10):L712-24. doi: 10.1152/ajplung.00099.2013.

262. Huang JJ, Soukup JM, Ghio AJ, Huang Y-CT. Host and Environmental Factors Affect Pulmonary Responses Measured in Bronchoalveolar Lavage. Inhalation Toxicology 2014; 26(1):30-35.

263. Sangani RG, Ghio AJ. Iron, Human Growth, and The Global Epidemic of Obesity. Nutrients 2013; 5(10):4231-4249; doi:10.3390/nu5104231.

264. Ghio AJ, Sangani RG, Roggli VL. Expanding the spectrum of particle- and fiber-associated interstitial lung diseases. Turkish Thoracic Journal 2014; 15:1-8.

265. Vaughan JM, Garrett BJ, Prophete C, Horton L, Sisco M, Soukup JM, Zelikoff JT, Ghio A, Peltier RE, Asgharian B, Chen LC, Cohen MD. A novel system to generate WTC dust particles for inhalation exposures. J Expo Sci Environ Epidemiol 2014; 24(1):105-12. doi: 10.1038/jes.2013.68..

266. Duncan KE, Cook PM, Gavett SH, Dailey LA, Mahoney RK, Ghio AJ, Roggli VL, Devlin RB. In vitro determinants of asbestos fiber toxicity: effect on the relative toxicity of Libby amphibole in primary human airway epithelial cells. Part Fibre Toxicol 2014; 11 (1):2

267. Wolff NA, Ghio AJ, Garrick LM, Garrick MD, Zhao L, Fenton RA, Thévenod F. Evidence for mitochondrial localization of divalent metal transporter 1 (DMT1). FASEB Journal 2014; 28:2134-45. doi: 10.1096/fj.13-240564.

268. Ghio AJ. Particle exposures and infections. Infection 2014; 42:459–467.269. Ghio AJ, Kummarapurugu ST, Tong H, Soukup JM, Dailey LA, Boykin E, Gilmour I, Ingram P,

Roggli VL, Goldstein HL, Reynolds RL. Biological effects of desert dust in respiratory epithelial cells and a murine model. Inhalation Toxicology 2014; 26 (5): 299-309.

270. Meier R, Cascio WE, Ghio AJ, Wild P, Danuser B, Riediker M. Associations of Short-Term Particle and Noise Exposures with Markers of Cardiovascular and Respiratory Health among Highway Maintenance Workers. Environ Health Perspect 2014; 122(7):726-732.

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271. Ghio AJ, Soukup JM, Dailey LA, Richards JH, Duncan KE, Lehmann J. Iron decreases biological effects of ozone exposure. Inhalation Toxicology 2014; 26 (7): 391–399.

272. Chiarella SE, Soberanes S, Urich D, Morales-Nebreda L, Nigdelioglu R, Green D, Young JB, Gonzalez A, Rosario C, Misharin AV, Ghio AJ, Wunderink RG, Donnelly HK, Radigan KA, Perlman H, Chandel NS, Budinger GR, Mutlu GM. β2-Adrenergic agonists augment air pollution-induced IL-6 release and thrombosis. J Clin Invest. 2014 May 27. pii:75157. doi:10.1172/JCI75157.

273. Hatch G, Duncan KE, Diaz-Sanchez D, Schmitt MT, Ghio AJ, Carraway MS, McKee J, Daily LA, Berntsen J, Devlin RB. Progress in Assessing Air Pollutant Risks from In Vitro Exposures: Matching Ozone Dose and Effect in Human Airway Cells. Toxicol Sci 2014; 141 (1):198-205. doi: 10.1093/toxsci/kfu115.

274. Fischer BM, Voynow JA, Ghio AJ. COPD: Balancing Oxidants and Antioxidants. International Journal of COPD 2015:10 261–276. doi: 10.2147/COPD.S42414.

275. Schreinemachers DM, Ghio AJ, Sobus JR, Williams MA. Perchlorate Exposure is Associated with Oxidative Stress and Indicators of Serum Iron Homeostasis Among NHANES 2005–2008 Subjects. Biomarker Insights 2015; 10: 9-19. doi: 10.4137/BMI.S20089.

276. Sangani RG, Ghio AJ, Parker J. Letter to the editor: Pleural plaques in smoking-associated fibrosis and pulmonary asbestosis. International Journal of Chronic Obstructive Pulmonary Disease 2015:10 869–871. doi: 10.2147/COPD.S83564.

277. Miller DB, Karoly ED, Jones JC, Ward WO, Vallanat BD, Andrews DL, Schladweiler MC, Snow SJ, Bass VL, Richards JE, Ghio AJ, Cascio WE, Ledbetter AD, Kodavanti UP. Inhaled Ozone (O3)-Induces Changes in Serum Metabolomic and Liver Transcriptomic Profiles in Rats. Toxicol Appl Pharmacol 2015; 286(2): 65-79. doi: 10.1016/j.taap.2015.03.025.

278. Ghio AJ. Letter to the editor: The IRONMAN trial: a protocol for a multicentre randomised placebo-controlled trial of intravenous iron in intensive care unit patients with anaemia. Crit Care Resusc 2015; 17 (2):144.

279. Ghio AJ, Stonehuerner J, Soukup JM, Dailey LA, Kesic MJ, Cohen MD. Iron diminishes the in vitro biological effect of vanadium. J Inorg Biochem 2015 Jun; 147:126-33. doi: 10.1016/j.jinorgbio.2015.03.008.

280. Ghio AJ, Pavlisko EN, Roggli VL. Iron and iron-related proteins in asbestosis. Journal of Environmental Pathology, Toxicology and Oncology 2015; 34(4): 277-285.

281. Cohen MD, Vaughan JM, Garrett B, Prophete C, Horton L, Sisco M, Ghio A, Zelikoff J, Chen L-C. Impact of acute exposure to WTC dust on ciliated and goblet cells in lungs of rats. Inhalation Toxicology 2015; 27 (7): 354-61. doi: 10.3109/08958378.2015.1054531.

282. Crans DC, Ghio A, Conte V. Preface: Celebrating vanadium science with leading bioinorganic contributions from the 9th International Vanadium Symposium. J Inorg Biochem 2015 Jun; 147:1-3. doi: 10.1016/j.jinorgbio.2015.05.006.

283. Cuevas AK, Niu J, Zhong M, Liberda EN, Ghio A, Qu Q, Chen LC. Metal rich particulate matter impairs acetylcholine-mediated vasorelaxation of microvessels in mice. Part Fibre Toxicol 2015 Jun 4; 12(1):14. doi: 10.1186/s12989-014-0077-x.

284. Soukup JM, Dailey LA, Ghio AJ. Particle retention by respiratory epithelial cells is associated with persistent biological effect. Inhalation Toxicology 2015; 27 (7): 335-41. doi: 10.3109/08958378.2015.1048910.

285. Yu YA, Hotten DF, Malakhau Y, Volker E, Ghio AJ, Noble PW, Kraft M, Hollingsworth JW, Gunn MD, Tighe RM. Flow Cytometric Analysis of Myeloid Cells in Human Blood, Bronchoalveolar Lavage, and Lung Tissues. Am J Respir Cell Mol Biol 2016; 54(1):13-24. doi: 10.1165/rcmb.2015-0146OC.

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286. Ghio AJ, Soukup J, Dailey L, Tong H, Kesic M, Budinger GS, Mutlu G. Wood smoke particle sequesters cell iron to impact a biological effect. Chem Res Toxicol 2015; 28(11):2104-11. doi: 10.1021/acs.chemrestox.5b00270.

287. Miller DB, Snow SJ, Schladweiler MC, Richards JE, Ghio AJ, Ledbetter AD, Kodavanti UP. Acute Ozone-Induced Pulmonary and Systemic Metabolic Effects are Diminished in Adrenalectomized Rats. Toxicological Sciences 2016; doi: 10.1093/toxsci/kfv331.

288. Miller DB, Ghio AJ, Karoly ED, Bell LN, Snow SJ, Madden MC, Soukup J, Cascio WE, Gilmour MI, Kodavanti UP. Ozone Exposure Increases Circulating Stress Hormones and Lipid Metabolites in Humans. Am J Respir Crit Care Med 2016; .

289. Schreinemachers DM, Ghio AJ. Effects of Environmental Pollutants on Cellular Iron Homeostasis and Ultimate Links to Human Disease. Environ Health Insights 2016 Mar 7;10:35-43. doi: 10.4137/EHI.S36225.

290. Smith GS, Ghio AJ, Stout JE, Messier KP, Hudgens EE, Murphy MS, Pfaller SL, Maillard JM, Hilborn ED. Epidemiology of nontuberculous mycobacteria isolations among central North Carolina residents, 2006-2010. J Infect 2016 Mar 17. pii: S0163-4453(16)30002-0. doi: 10.1016/j.jinf.2016.03.008.

291. Ghio AJ, Schreinemachers DM. Heme oxygenase activity correlates with serum indices of iron homeostasis in healthy non-smokers. Biomarker Insights 2016; in press.

292.

Letters to the editor (unpublished) 1. Ghio AJ. Provision of iron to COPD patients. BMJ Open 2015.

http://bmjopen.bmj.com/content/5/7/e007911/reply#bmjopen_el_9304

Publications and Appearances in Lay Media1. Ghio AJ. Asbestosis: overdiagnosed? Raleigh News & Observer, April 12, 2004, page 11A.2. Ghio AJ. Assembly-line diagnoses of lung diseases. Raleigh News & Observer, March 22, 2006,

page 15A.3. Appearance in “Air Aware” on the Weather Channel (2006). See:

http://www.airnow.gov/index.cfm?action=movie.main

Proceedings, books, and book chapters:1. Castellan RM, Olenchock SA, Kinsley KB, Townsend MC, Keimig DG, Ghio AJ, Piacitelli GM.

Airborne endotoxin concentrations in the cotton industry; Effect of cotton growing area. In: Wakelyn PJ, Jacobs RR (Eds), Cotton Dust: Proceedings of the twelfth Cotton Dust Research Conference. Memphis, National Cotton Council, 1988, pp. 3-46.

2. Ghio AJ, Renzetti AD Jr., Crapo RO. ILO (1980) Classification and the association of small opacities with aging. In: Proceedings of the VIIth International Pneumoconioses Conference, pp. 1336-1337, 1990.

3. Ghio AJ, Kennedy TP, Baser M, Rawlings WR, Rao NV, Hoidal JR. Kaolin generates OH and causes hemolysis by acting as a Fenton reagent. In: Proceedings of the International Conference on Health Related Effects of Phyllosilicates. J. Bignon, Ed. NATO ASI, Springer-Verlag, 1988, pp. 360-368.

4. Coffin DL, Ghio AJ. Relative intrinsic potency of asbestos and erionite fibers: Proposed mechanism of action. In: Proceedings of the NATO Advanced Research Workshop on Mechanisms in Fibre Carcinogenesis. Plenum Press, New York, 1991, pp 71-80.

5. Ghio AJ. Silicosis. In: Conn’s Current Therapy. W.B. Saunders Company, New York, 1996, pp.

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http://www.airnow.gov/index.cfm?action=movie.main

http://bmjopen.bmj.com/content/5/7/e007911/reply#bmjopen_el_9304


231-233.6. Ghio AJ and Samet JM. Metals and air pollution particles. In: Air Pollutants and Effects on

Health. Holgate, Koren, Samet, and Maynard, editors. Academic Press, London, 1999, pp. 635-651.

7. Ghio AJ. The role of metals in the toxicity of air pollution particles. Proceedings of the World Equine Airways Symposium, 1999; pp. 1-13.

8. Devlin RB, Ghio AJ, Costa DL. Responses of the lung to inhaled particles. Cellular Responses. In: Particle-Lung Interactions. P. Gehr and J. Hyder, editors. Marcel Dekker, Inc., New York, 2000, Volume 143, pp. 437-472.

9. Ghio AJ, Vandenberg J, Soukup J, Becker S. Overview of the PM Health Effects Research Program. In: Cotton and Other Organic Dusts. Proceedings of the Twenty-Fourth Cotton and Other Organic Dusts Research Conference. Beltwide Cotton Conferences, January 7th to 8th, 2000. P.J. Wakelyn, R.R. Jacobs, R. Rylander, editors. National Cotton Council of America, pp. 212-219.

10. Devlin RB, Ghio AJ, Samet JM, Carter JD, Frampton MW. Pulmonary Toxicity of Utah Valley PM: Are Empirical Indices of Adverse Health Effects Coherent with the Epidemiology? In: Relationships Between Acute and Chronic Effects of Air Pollution (U.Mohr, ed.); ILSI Press, 2001, pages 159-168.

11. Ghio AJ. Interstitial Lung Disease. In: Respiratory Care: Principles and Practice. D. Hess, N.R. MacIntyre, S.C. Mishoe, W.F. Galvin, A.B Adams, and A.B. Saposnick, editors. W.B. Saunders Company, New York, 2002, pages 955-967.

12. Johnson TA, Devlin RB, Ghio AJ, Huang YC, Costa DL, Bromberg P, Cascio WE. Cardiopulmonary effects of nebulized residual oil fly ash in anesthetized pigs. In: Critical Issues in Inhalation Research. Mechanistic, Clinical and Epidemiologic. U. Heinrich and U. Mohr, Editors. Fraunhofer IRB Verlag, Stuttgart, 2002, pages 199-212.

13. Ghio AJ. Silicosis. In: Conn’s Current Therapy. Elsevier Science, New York, 2003, pp. 271-274.14. Ghio AJ. Aetiological agents: Outdoor environment and agents. In: Proceedings of a Workshop on

inflammatory airway disease: defining the syndrome. Havemeyer Foundation Monograph 9, R & W Publications, 2003, pages 29 - 30.

15. Ghio AJ. The diagnostic approach to chronic cough in people. In: Proceedings of a Workshop on inflammatory airway disease: defining the syndrome. Havemeyer Foundation Monograph 9, R & W Publications, 2003, pages 23 – 24.

16. Ghio AJ, Huang YC, Bennett WD, Bromberg PA, Devlin RB. A similar biological response following exposure to different types of particles suggests a common mechanism of injury. In: Effects of Air Contaminants on the Respiratory Tract- Interpretations from Molecular to Meta Analysis. U. Heinrich, Editor. Fraunhofer IRB Verlag Stuttgart, 2004, pages 259-268.

17. Samet JM, Ghio AJ. Particle-associated metals and oxidative stress in signaling. In: The Toxicology of Particles (Donaldson K and Borm P, editors). CRC Press, Boca Raton, 2007, pages 161-181.

18. Ghio AJ, Samet JM. Biological effects of vanadium in the lung. Vanadium: The Versatile Metal. Kustin K, Pessoa JC, Crans DC (editors). American Chemical Society, Washington DC, 2007; pages 240-248.

19. Ghio AJ, Bromberg PA. Environmental Lung Disease. In: Netter’s Internal Medicine, second edition (Runge MS and Greganti A, editors), 2008, pages 150-154.

20. Short K, Ghio AJ. Interstitial Lung Disease. In: Respiratory Care: Principles and Practice, 2nd edition. D. Hess, N.R. MacIntyre, S.C. Mishoe, W.F. Galvin, A.B Adams, and A.B. Saposnick, editors. W.B. Saunders Company, New York, 2011, pages 765-778.

21. Ghio AJ, Huang YCT. Role of chemical composition in determining the cardiovascular effects of

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particles. In: Cardiovascular Effects of Inhaled Ultrafine and Nanosized Particles (Cassee FR, Mills NL, and Newby D, editors). Hoboken, New Jersey: John Wiley & Sons, Inc., 2011, pages 145-170.

22. Huang Y-CT, Ghio AJ, and Maier LA, editors. A Clinical Guide to Occupational and Environmental Lung Diseases. Springer, New York City, 2012.

23. Ghio AJ. Chapter 9: Pneumoconiosis in the 21st century: practical considerations. In: A Clinical Guide to Occupational and Environmental Lung Diseases. Huang YHC, Maier L, Ghio AJ (editors). Springer, New York City, 2012, pages 171-188.

24. Ghio AJ. Oxidative injury caused by cigarette smoking and air pollution. In: Oxidative Stress in Applied Basic Research and Clinical Practice – Studies on Respiratory Disorders. Jindal SK, Ganguly NK, Barne P, Pawankar R, Biswal S (editors). Springer, New York, 2015, pages 131-150.

25. Short K, Ghio AJ. Interstitial Lung Disease. In: Respiratory Care: Principles and Practice, 3rd edition. D. Hess, N.R. MacIntyre, S.C. Mishoe, W.F. Galvin, A.B Adams, and A.B. Saposnick, editors. W.B. Saunders Company, New York, 2015, pages.

Invited Presentations:1. Ghio AJ. Current guidelines and controversies in the prediction of pulmonary function. Annual

Meeting of the National Society for Cardiovascular and Pulmonary Technology, Denver, Colorado, 1988.

2. Ghio AJ, Crapo RO, Elliott CG, Berlin SL. Is pulmonary function inherited? DuPont Critical Care/ACCP Young Investigator's Award, 1988. ACCP Annual Conference, 1988.

3. Ghio AJ. Lung injury after exposure to silica and silicates. Duke University Medical Grand Rounds, Durham, North Carolina, November 8, 1991.

4. Ghio AJ. The role of iron in lung injuries. Duke University Marine Biology Center, Durham, North Carolina, February 22, 1992.

5. Ghio AJ. The association between iron, oxidant generation, and lung injury after silica exposure. University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, March 8, 1993.

6. Ghio AJ. Oxidant generation and lung injury after silica and silicates. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, West Virginia University School of Medicine, Morgantown, West Virginia, April 16, 1994.

7. Ghio AJ. Lung injury after silica instillations is associated with an accumulation of iron in the rat. Conference on Oxygen Radicals and Lung Injury, Morgantown, West Virginia, September 1, 1994.

8. Ghio AJ. The role of iron in injury after asbestos exposure. National Institute for Environmental Health Sciences, Research Triangle Park, North Carolina, September 17, 1994.

9. Ghio AJ. Oxidant generation and lung injury after exposure to particulate air pollutants correlate with iron concentrations. Human Studies Division, Environmental Protection Agency, Chapel Hill, North Carolina, October 23, 1994.

10. Ghio AJ. The accumulation of iron in the rat after intratracheal instillation of coal dust. Fourth symposium on respirable dust in the mineral industries. Pittsburgh, Pennsylvania, November 9, 1994.

11. Ghio AJ. Metals and injury after air pollution particulate exposure. NYU Institute for Environmental Medicine, Tuxedo, New York, February 8, 1995.

12. Ghio AJ. Iron and lung injury after particulate air pollution. Visiting Scholar Talk, Duke University, Durham, North Carolina, March 3, 1995.

13. Ghio AJ. Potential causative agents: Biological evidence for mineral dusts. Particulate Matter: Health and Regulatory Issues, Air and Waste Management Association, April 6, 1995.

14. Ghio AJ, Stonehuerner J, Pritchard RJ, Quigley DR, Dreher KL, Costa DL. Humic-like substances in air pollution particulates correlate with concentrations of transition metals and oxidant generation.

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Second Colloquium on Particulate Air Pollution and Health. Park City, Utah, May 1, 1996.15. Ghio AJ, Carter JD, Samet JM, Reed W, Quay J, Dailey LA, Richards JH, Devlin RB. Respiratory

epithelial cell production of lactoferrin after in vitro exposure to an air pollution particle is metal dependent. Second Colloquium on Particulate Air Pollution and Health. Park City, Utah, May 2, 1996

16. Ghio AJ, Meng ZH, Hatch GE, Costa DL. The role of transition metals in lung injury after particle exposure. Eleventh Annual International Symposium of the Air and Waste Management Association. Research Triangle Park, May 8, 1996.

17. Ghio AJ. Human exposures measurement- metals. Workshop on Person Exposure/Health Effects. National Urban Air Toxics Research Center. Reston, Virginia, April 16-17, 1997.

18. Ghio AJ. Role of transition metals in PM10-related adverse health effects. NHEERL Open House, Research Triangle Park, NC, September 30, 1997.

19. Ghio AJ, Piantadosi CA, Stonehuerner J, and Crumbliss AL. The role of silicate chelated iron in oxidant generation. Duke University Marine Biology Center Conference on Assessments of Oxidative and Nitrosative Stress. Duke University Medical Center, Durham, North Carolina, February 20, 1998.

20. Ghio AJ, Matalon S (Moderators). Acute lung injury. Poster discussion session. American Thoracic Society International Conference, Chicago, Illinois. April 26, 1998.

21. Ghio AJ. Host response after respiratory exposures to metal. Comprehensive Cancer Center, Department of Cancer Biology, Wake Forest School of Medicine, July 10, 1998.

22. Ghio AJ. Particulate-induced airway disease. World Equine Airways Symposium. University of Guelph, Guelph, Ontario. August 5, 1998.

23. Bromberg, PA and Ghio AJ. Effects of air pollution particles and metals on the respiratory tract. University of North Carolina Medical Grand Rounds, Chapel Hill, North Carolina, October 29, 1998.

24. Ghio AJ. Utah Valley Particles: Correlations between epidemiology and biological effects in cell models, animals, and humans. NHEERL Open House, Research Triangle Park, NC, November 5, 1998.

25. Ghio AJ. Toxicity of Utah Valley Particles. American Scientist Seminars for Science Journalists, Sigma Xi, Research Triangle Park, North Carolina, September 7, 1999.

26. Ghio AJ. Overview of the PM Health Effects Research Program. Beltwide Cotton Conferences 2000, Marriott Riverside Convention Center, San Antonio, Texas, January 7, 2000.

27. Ghio AJ. Old and New Targets: From Bench to Bedside to ICU. Inhaled Environmental/Occupational Irritants and Allergens: Mechanisms of Cardiovascular and Systemic Responses. Embassy Suites, Scottsdale, Arizona, April 1, 2000.

28. Ghio AJ, Richards JH, Dailey LA, Hatch GE, Madden MC. The effects of oxidants on modifying the toxicity of ambient PM. Society of Toxicology Annual Meeting, Pennsylvania Convention Center, Philadelphia, Pennsylvania, March 23, 2000.

29. Ghio AJ. Current hypotheses on the role of chemical composition in particle toxicology. American Thoracic Society Annual Conference, Toronto, Ontario, Canada, May 8, 2000.

30. Ghio AJ. Comparison of epidemiologic and clinical studies. International Congress on Environmental Health, Fourth Annual Meeting of the International Society of Environmental Medicine, Hanover Medical School, Hanover, Germany, October 4, 2000.

31. Ghio AJ. Asbestos-related lung injury. North Carolina Industrial Commission, Raleigh, North Carolina, October 13, 2000.

32. Ghio AJ. Iron metabolism in the lung and its disruption by asbestos and air pollution particles. University of Pittsburgh, February 15, 2001.

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33. Ghio AJ. Meet the Professor: Occupational lung disease. A particle is a particle is a particle. Annual Conference of American College of Chest Physicians, Philadelphia, PA, November 8, 2001.

34. Ghio AJ, Nozik-Grayck E, Turi J, Jaspers I, Mercatante DR, Kole R, Piantadosi CA. Iron uptake in bronchial epithelial cells requires O2

- transport by anion exchange protein 2. Annual Conference of the Oxygen Society, Raleigh, NC, November 17, 2001.

35. Ghio AJ. DMT1/Nramp2/DCT1/SLC11A2 in the lung. Department of Biochemistry, State University of New York, Buffalo, New York, January 24, 2002.

36. Ghio AJ. Lung injury after exposure to air pollution particles from the Utah Valley. EPA Science Forum 2002, Ronald Reagan Building and International Trade Center, Washington D.C., May 2, 2002.

37. Ghio AJ. Medical Grand Rounds: Pulmonary and systemic response to particles. East Carolina University School of Medicine, May 31, 2002.

38. Ghio AJ. Diagnostic approach to chronic cough in people and Outdoor environment and airways. Inflammatory Airway Disease: Defining the Syndrome. Boston, Massachusetts, October 1, 2002.

39. Ghio AJ. Modulation of transition metal-induced injury by metal transport proteins. Annual Conference of the Society of Toxicology, Salt Lake City, Utah, March 11, 2003.

40. Ghio AJ. Clinical Studies with Ambient Particulate Exposures: Utah Valley and Concentration Studies. Fourteenth Congress of the International Society for Aerosols in Medicine (ISAM), Baltimore, Maryland, June 14-18, 2003.

41. Ghio AJ. DMT1 expression affects lung injury following particle exposure. Center for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina, September 4, 2003.

42. Ghio AJ. The biological effect of air pollution particles and pulmonary fibrosis in a textile worker. University of Illinois at Chicago, March 16 and 17, 2004.

43. Ghio AJ. Asbestosis in North Carolina. Annual Meeting and Scientific Session of the North Carolina Thoracic Society. Asheville, North Carolina, April 17, 2004.

44. Ghio AJ. Exacerbations of COPD and asthma by environmental exposures. Annual Meeting of the National Gerontological Nursing Association. Las Vegas, October 15, 2004.

45. Ghio AJ. Air pollution particles and respiratory health in the elderly. Annual Meeting of the American Public Health Association. Washington D.C., November 8, 2004.

46. Ghio AJ. Iron homeostasis in the lung. Third International Workshop on Iron and Copper Homeostasis (TIWICH), Viña del Mar City, Chile, December 9-12, 2004.

47. Ghio AJ. Biological effects of air pollution particles and iron metabolism. Curriculum in Toxicology, University of North Carolina, Chapel Hill, North Carolina, January 24, 2005.

48. Ghio AJ. Effects of particles on iron transport and the immunotoxicologic outcomes. Annual Meeting of the Society of Toxicology. New Orleans, March 8, 2005.

49. Ghio AJ, Stonehuerner J, Richards J, Madden M, Yang F, Piantadosi CA. Carbon monoxide exposure disrupts iron homeostasis. HO Conference 2005. The Fourth International Congress. Boston, MA, October 7, 2005.

50. Ghio AJ. Iron homeostasis and particle-associated lung injury. Harvard School of Public Health - NIEHS Center for Environmental Health. Metals Core. November 10, 2005.

51. Ghio AJ. Pulmonary Grand Rounds: Iron homeostasis and particle-associated lung injury. East Carolina University School of Medicine, March 1, 2006.

52. Garrick MD, Ghio A, Garrick LM. Is elevated DMT1 involved in the response to inflammation? A non-GI perspective. Workshop on anemias of inflammation and chronic disease, Annapolis, Maryland, May 2, 2006.

53. Ghio AJ. Air pollution and cardiopulmonary health: metals. Air & Waste Management

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Association Annual Conference, New Orleans, LA, June 22, 2006.54. Ghio AJ. Utah Valley experiments. Endicott House Symposium on Emissions from Large

Industrial Sources. MIT Laboratory for Energy and Environment and Northeast States for Coordinated Air Use Management, Dedham, MA, August 16, 2006.

55. Ghio AJ. Biological effects of vanadium in the respiratory tract. Fifth International Symposium on Chemistry and Biological Chemistry of Vanadium, American Chemical Society National Meeting & Exposition, San Francisco, CA, September 11, 2006.

56. Ghio AJ. The role of transition metals in particulate matter induced toxicity. Mechanisms of particulate matter induced mortality (Symposium). Annual Conference of the American Thoracic Society, San Francisco, May 20, 2007.

57. Ghio AJ. Particulate matter in cigarette smoke alters iron homeostasis producing an oxidative stress and inflammation. Department of Physiology, East Carolina University, Greenville, NC, November 1, 2007.

58. Ghio AJ. Particulate matter, cigarette smoke, and iron homeostasis. Louisiana State University Medical Center, New Orleans, LA, January 9, 2007. Air pollution, COPD, and asthma. Louisiana State University Medical Center, New Orleans, LA, January 10, 2008.

59. Ghio AJ. A shared mechanism of lung injury after air pollution particle exposure and cigarette smoking. University of North Carolina, Pulmonary and Critical Care Division, Research Conference, February 8, 2008.

60. Ghio AJ. Air pollution, cigarette smoking, iron, and susceptibility to disease. Northwestern University, Feinberg School of Medicine, Pulmonary and Critical Care Division, Chicago, February 18, 2008.

61. Ghio AJ. Role of Iron Sequestration in Host Response to Particles and Fibers. Particle interactions with biomaterials: beyond opsonization (symposium). Annual Conference of the Society of Toxicology, Seattle, 2008.

62. Mackenzie B, Shawki A, Ghio AJ, Stonehuerner JD, Zhao L, Ghadersohi S, Garrick LM, Garrick MD. A role for the divalent metal-ion transporter (DMT1) is doubtful in the mechanism by which calcium-channel blockers reverse iron overload. Experiment Biology, San Diego, April 8, 2008.

63. Cohen MD, Ghio AJ. Vanadium Induces AIH: Implications for the Pulmonary Immune System. 6th International Symposium on Chemistry and Biological Chemistry of Vanadium, Lisbon, Portugal, July 17-19, 2008.

64. Ghio AJ. Air pollution and cigarette smoking: particle-associated lung injuries. University of North Carolina Pathology Grand Rounds, October 16, 2008.

65. Ghio AJ. Oxidative and nitrosative stress associated with air pollution. Annual Conference of the Society of Toxicology, Baltimore, MD, March 15, 2009.

66. Ghio AJ. Historic perspective of occupational and environmental lung disease. American Thoracic Society, New Orleans, May 14, 2010.

67. Ghio AJ. Iron and oxidative stress in normal and diseased tissue. Gordon Research Conference: Metals in Medicine. Proctor Academy, Andover, NH, June 27, 2010-July 2, 2010.

68. Ghio AJ. Disruption of iron homeostasis in the lung after cigarette smoking. AMGEN, Thousand Oaks, CA, July 22, 2010.

69. Ghio AJ. Iron homeostasis and biological effects of mineral oxide particles. Annual Conference of the Geological Society of America, Minneapolis, MN, October 10, 2011.

70. Ghio AJ. Wood Smoke Particles Sequester Mitochondrial Iron Resulting in Superoxide Generation and Biological Effect. Society of Toxicology Annual Conference, San Francisco, CA, March 15, 2012.

71. Ghio AJ. Interstitial lung diseases: Are they all idiopathic? ATS 2012 International Conference,

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San Francisco, CA. May 19, 2012.72. Ghio AJ. The Burning of Biomass Generates Humic-like Substances Which Can Impact Human

Health Via Iron Complexation. International Smoke Symposium, Washington DC, October 24, 2013.

73. Ghio AJ. Biological effects of particles. Duke University Pulmonary Grand Rounds, Durham, NC, March 14, 2014.

74. Ghio AJ. Asbestosis. IPF: From Pathogenesis to Cure. AIPO Annual Meeting. Rome, Italy, May 9, 2014.

75. Ghio AJ. Particle exposures and toxicity. Annual Meeting of the Allegheny-Erie Society of Toxicology Regional Chapter, Morgantown, West Virginia, May 15, 2014.

76. Ghio AJ. The biological effects of vanadium and its interactions with iron. Ninth International Vanadium Symposium, Padova, Italy, July 2, 2014.

77. Peden DB, Ghio AJ. Outdoor air quality: what do all those colors mean? American Academy of Allergy, Asthma & Immunology Annual Meeting, Houston, Texas, February 21, 2015.

78. Ghio AJ. Particles, iron, and biological effects. Department of Pediatrics, Virginia Commonwealth University Medical Center, Richmond, VA, March 27, 2015.

Peer Review Panels, Workshops, and Advisory Committee Participation:1) U.S. EPA PM AQCD Review Workshop. Toxicology. ERC, NHEERL, EPA, Research Triangle

Park, January 13, 1995.2) US EPA Particulate Matter Research Needs Workshop. Mechanisms of response to particulate

matter. Sheraton Imperial Hotel, Research Triangle Park, NC, September 4, 1996.3) Clinical Studies of Particulate Matter. What has been done and what could be done to assess health

effects of PM in humans? Alexandria, VA, April 30 and May 1, 1997.4) Committee to Advise on Health Issues of Individuals Exposed to the Particles From Wildland Fires

in the Southwest Pacific. State Department, Washington DC, October, 1997.5) Committee for NHEERL Open House. Human Studies Division representative, 1998.6) PM Review (Air Quality Criterion Document) Workshop. Toxicology/Pathophysiology. Embassy

Suite Hotel, Cary, North Carolina, April 6-9, 1999.7) Third Colloquium on Particulate Air Pollution and Human Health. What are the toxicological

mechanisms underlying adverse health effects from PM? Durham Marriott, Durham, North Carolina, June 6-8, 1999.

8) Rebecca Bascom, Lucas Neas, Andrew J. Ghio (Chairpersons). Inhaled Environmental/Occupational Irritants and Allergens: Mechanisms of Cardiovascular and Systemic Responses. March 31- April 2, 2000, Embassy Suites, Scottsdale, Arizona.

9) Committee to Advise on Department of Justice Environmental Litigation. Department of Justice, Bicentennial Building, Washington DC, September 20, 2000.

10) Defense and Health Related Research Peer Review Panel (Lung Panel), Congressionally Directed Medical Research Programs Defense Health Research Program, Holiday Inn Dulles, Sully Road, Virginia, October 19-20, 2000.

11) Diets, Antioxidants and Environmental Influences on Health and Disease. Ronald Mason and Ben Van Houten, Chairs. March 13 and 14, 2001. National Institutional for Environmental Health Sciences, Research Triangle Park, North Carolina.

12) Second Workshop. EPA-GSF Cooperation on Environment and Health. Moderator on Coherence. Elmau, Germany. September 9-12, 2001.

13) Ghio A (Chair). Susceptibility, genetics and biological indicators associated with plenary session. Particulate Matter: Atmospheric Sciences, Exposure and the Fourth Colloquium on PM and Human

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Health. March 31 - April 4, 2003. Pittsburgh, Pennsylvania.14) Cohen M and Ghio AJ (co-chairs). Altered Iron Homeostasis as a Basis for Pulmonary

Immunotoxicologic Effects of Particulate Matter (PM). Annual Meeting of the Society of Toxicology. New Orleans, March 8, 2005.

15) Nel A and Ghio A. Oxidative stress. PM Centers Kick-off. US Environmental Protection Agency, Research Triangle Park, North Carolina, November 30, 2005.

16) Ghio AJ. Nanomist Oxidative Stress Meeting. London, England, November 15th and 16th, 2006. 17) Ghio AJ. Panel Discussion. Biological plausibility of health effects due to air pollutants. US EPA

Workshop on Interpretation of Epidemiologic Studies of Multi-pollutant Exposure and Health Effects. Chapel Hill, NC, December 13 and 14, 2006.

18) Mauderly JL, Ghio AJ, Abraham JL, facilitators. Pulmonary Toxicology. Thematic poster session, American Thoracic Society International Conference, May 20, 2007.

19) Ghio AJ. Carbon monoxide ISA Draft Internal Peer Review Panel, November 19, 2008.20) Pulmonary non-tuberculous mycobacterial disease statement of need and a national research agenda.

Arlington, Virginia. October 28, 2009. 21) National Institute for Occupational Safety and Health, Coal Workers’ Health Surveillance Program

B Reader Meeting. Transition to Digital Images. Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV, July 6, 2010.

22) Marc Fariss, Andrew Ghio, session chairpersons. Emerging Mechanistic Targets in Lung Injury Induced by Combustion-generated Particles. Society of Toxicology (SOT) Annual Meeting, March 15, 2012, San Francisco, CA.

23) Huang YC, Ghio AJ, Maier LA (co-chairs). Post-graduate course Novel Approaches to Investigate Occupational and Environmental Causes in Common Lung Diseases. ATS 2012 International Conference, San Francisco, CA. May 19, 2012.

24) Mitch Cohen, Andy Ghio, Craig McLauchlan, organizers. 8th International Vanadium Symposium: Chemistry, Biological Chemistry, & Toxicology, August 15-18, 2012, Washington, DC USA.

25) Fortoul T, Ghio AJ. Co-chairs. Environmental vanadium & environmental/occupational exposures to vanadium. 8th International Vanadium Symposium: Chemistry, Biological Chemistry, & Toxicology, August 18, 2012, Washington, DC USA.

26) External Advisory Committee, "Trace elements in autopsy tissues of World Trade Center decedents," (NIOHS grant 1 U01 OH010395-01A1; July 2013 - June 2015).

27) Ghio AJ. Session chair. Environmental biology of trace metals. Biometals 2014. Durham, North Carolina. July 14, 2014.

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