Planning for CPIC Database content,

functionality, API

Listening Sessions

CPIC Informatics Call 11/27/18

CPIC Call 12/6/18

Developing new tools to expand and customize use of CPIC guidelines

• Make guidelines more computable

– Implementation resources available on www.cpicpgx.org

– Database for implementation resources

– Application Programming Interface (API)

• Will enable use of CPIC knowledge in new ways across a broad potential user community

The established CPIC implementation resources provide a foundation for these new tools

• CPIC Informatics work group lead the development of resources that accompany each guideline• First set of resources published in 2014 (abacavir/HLA guideline update)

• Comprehensive translation tables from genotype to phenotype to clinical recommendation is one unique resource

Genotype

Phenotype

Recommendation

Hoffman JM et al. J Am Med Inform Assoc. 2016 https://cpicpgx.org/guidelines/

Examples of potential use casesRetrieve a summary of the drugs and genes that are associated with a CPIC guideline• Uses the standard nomenclatures already in CPIC guidelines (e.g. RxNorm for medications and HGNC for genes)

Examples of potential use casesRetrieve a summary of the drugs and genes that are associated with a CPIC guideline• Uses the standard nomenclatures already in CPIC guidelines (e.g. RxNorm for medications and HGNC for genes)

Filter available drug/gene information to specific local needs • CPIC guideline may include information on 7 tricyclic antidepressants, but users may only want to download

applicable information (e.g. CDS language) for the drugs on the hospital’s formulary• Further, show recommendations based on one gene (e.g. CYP2D6) for an antidepressant – not the second gene (e.g.

CYP2C19) for which testing is not yet available at the site

Retrieve all drugs with CPIC guidelines and return a summary of all actionable diplotype/phenotype data with the corresponding CDS alert language• These data would be used on an ongoing basis• This data may be sent to different applications and/or users

Examples of potential use casesRetrieve a summary of the drugs and genes that are associated with a CPIC guideline• Uses the standard nomenclatures already in CPIC guidelines (e.g. RxNorm for medications and HGNC for genes)

Filter available drug/gene information to specific local needs • CPIC guideline may include information on 7 tricyclic antidepressants, but users may only want to download

applicable information (e.g. CDS language) for the drugs on the hospital’s formulary• Further, show recommendations based on one gene (e.g. CYP2D6) for an antidepressant – not the second gene (e.g.

CYP2C19) for which testing is not yet available at the site

Retrieve all drugs with CPIC guidelines and return a summary of all actionable diplotype/phenotype data with the corresponding CDS alert language• These data would be used on an ongoing basis• This data may be sent to different applications and/or users

Query Examples

/diplotype_view?genesymbol=eq.UGT1A1&diplotype=eq.*27/*80

/recommendation?genotypes=cs.”UGT1A1:Poor metabolizer”

Feedback: Questions to guide discussion

• How do you anticipate you would use the CPIC database/API?

• Of the existing CPIC implementation resources, what is the top priority to build in the database?

• What support or guidance would you need to use the CPIC database/API?

• How should the CPIC guideline development process change to support these new resources?

Next steps

• Evaluate feedback from both listening sessions and determine where additional information may be needed

• Additional review with CPIC leadership and steering committee

• Ongoing progress reports on CPIC Informatics calls with routine updates to all of CPIC