principles of immunology overview of innate immunity 1/19/06 “education is not preparation for...
TRANSCRIPT
Principles of Immunology
Overview of Innate Immunity1/19/06
“Education is not preparation for life. Education is life itself.”
John Dewey
Review(T/F)
Jenner was the first to introduce variolation
Innate immune responses are specific T cells are either T-helper or T-
cytotoxic cells Immunological memory results in an
amanestic response All antigens are immunogens
Innate Immunity
Nonspecific host defenses that exist prior to exposure to an antigen. Involves the following components:
Anatomic Physiologic Phagocytic Inflammatory
Word List Antibody Antigen Complement Endocytosis Humoral Macrophage Monocyte Neutrophil
Barriers to Antigenic Insult
Anatomic Skin Mucous membranes
Physiologic Temperature pH Chemical mediators
Cellular and Inflammatory Components of Innate Immunity
Cellular Phagocytic cells
Inflammatory Vasodilation Capillary permeability
Anatomic Barriers
Skin Epidermis Dermal layer Sebaceous glands Normal flora
Anatomic Barriers
Mucous membranes Physical barrier Secretions Cilia Normal flora
Physiologic Barriers
Temperature Varies by species Febrile response
Endogenous pyrogens
pH Skin GI tract
Physiologic Mediators of Innate Immunity
Chemical mediators Enzymes Interferon Complement
Three pathways Classical MB Lectin Alternative
Physiologic Mediators of Innate Immunity(cont’d)
Chemical mediators Collectins Toll-like receptors Acute phase proteins
Cellular Component of Innate Immunity
Phagocytic cells Monocytes Neutrophils Macrophages
Non-Phagocytic cells Natural killer cells
Inflammatory Response
Hallmarks of inflammation Rubor Tumor Calor Dolor
Primary cell Activated macrophage
Inflammatory Response(cont’d)
Biological effects Vasodilation Capillary permeability Phagocyte migration
Inflammatory Response(cont’d)
Chemical mediators of inflammation Histamine Kinin system Fibrin system