Tissues,OrgansandPhysiologyModeling

CurrentAreaofResearchInterest• Vision,VisualSystemFunc:on,VisualProsthesis• DynamicNeuroimagingofBrainFunc:onMEG,fMRI,Op:calImaging,neuralcurrentMRISourcecharacteriza:on,mul:‐modalityintegra:on• UnderstandingNeuralComputa:on

ChallengesthatMaybeAddressedwithAdvancedCompu<ngandMathema<csCapabili<es• LargescaleBiophysicalModelingMRIfunc:onalContrast,NeuralS:mula:on

• Synthe:cCogni:on,SensoryInforma:onProcessing

• Neuromime:candNeuromorphicComputerSystems

JohnS.GeorgeTechnicalStaffMemberLosAlamosNa:onalLaboratory

DOE/OfficeofScience ExtremeBiology August17‐19

Tissues,OrgansandPhysiologyModeling

CurrentAreaofResearchInterest• Simula(on‐basedresearchinneuroscience• biologicallydetailed,physiologicalmodeling• learning&plas(city,large‐scalenetworkdynamics

ChallengesthatMaybeAddressedwithAdvancedCompu@ngandMathema@csCapabili@es

• large‐scaletheoriesofbrainfunc(on&dysfunc(on• predic(vemodelsfordrugdesign• informa(onprocessinginbraincircuitry

SeanHill(PhD)ProjectManager‐Computa(onalNeuroscienceBlueBrain/EPFL

Opportuni(esinBiologyattheextremescaleofcompu(ng Aug17‐19,2009

Tissues,Organs,andPhysiologyModelling

NeuralNetworksimula9onmethods

Challengespresentedbyavailabilityofverylargeparallelcomputers• Loadbalancewhenlargestneuronismuchlargerthanaveragecomputa9onalloadperprocessor• Overlappingcomputa9onandspikeexchange:avoidingcommunica9onbandwidthlimita9ons

MichaelHinesSr.ResearchScien9stComputerScienceYaleUniversity

Opportuni9esinBiologyattheextremeScaleofCompu9ng:May11‐12

Tissues,Organs,andPhysiologyMul4scaleModelingofArterialTrees

Computa4onalChallenges: Solu4onoflinearsystemson1000sProcessors Couplingheterogeneouscodes:

atomis4c‐con4nuum

GeorgeEmKarniadakisProfessorofAppliedMathema4csBrownUniversity

Opportuni4esinBiologyattheextremeScaleofCompu4ng:May11‐12

Tissues,Organs,andPhysiologyModeling

ResearchInterest:HighPerformanceI/O• NovelapproachestoparallelI/Oso;ware• Data‐intensivecompu@ng• I/OInterfacesforHPCApplica@ons

ChallengesaddressedwithAdvancedCompu>ng• Mee@ngtheI/OperformancerequirementsofBiologyApplica@ons• Providingefficient,usableinterfacestoI/OandstorageforBiology• Furthereduca@onofbestprac@cesI/Otechniques

SamLangPVFSTechnicalLeadArgonne/MCS

ExtremeScaleBiology August17,2009

Tissues,Organs,andPhysiologyModeling

CurrentAreaofResearchInterest• ExperimentalandComputa:onalsimula:onofbiologicalflows• Hemodynamicsofthecaro:dbifurca:onandvasculargraBs.• Hydrodynamicsofcerbrospinalfluidmo:oninthespinalcanal

ChallengesthatMaybeAddressed• Fluidsdynamicssimula:onsofmanypa:entspecificgeometriesandflowsforcorrela:onbetweenmechanicalforces(shearstressandpressure)withbiologicalmarkerssuchasdiseasepresenceand/orprogression.

FrancisLothAssociateProfessorUniversityofAkron

Opportunities in Biology at the Extreme Scale of Computing August 17-19, 2009

Tissues,OrgansandPhysiologyModeling

CurrentAreaofResearchInterest[Includegraphic]• BiomedicalModelingatmul8scales• BiomedicalAnalysis• BiomedicalDatamanagement

ChallengesthatMaybeAddressedwithAdvancedCompu>ngandMathema>csCapabili>es

• Limitstowhatunderlyingmechanis8calgorithmsarecomputable• Limitstowhatunderlyingmechanis8calgorithmscanbevalidatedwiththeoryordata• 

PeterLyster DrNa8onalIns8tutesofHealth

DOE/OfficeofScienceGraphic NameofWorkshop Date

Op8onalphotoofworkshoppar8cipant

Illustra8vefigurethatdescribesresearcheffort

CurrentAreaofResearchInterest• Simula(on‐basedresearchinneuroscience• high‐performancecompu(ngandsimula(on‐steering• integra(vecompu(ngworkflows

ChallengesthatMaybeAddressedwithAdvancedCompu<ngandMathema<csCapabili<es

• hypothesis‐drivendrugdevelopment• personalizedmedicine• reducinganimalexperimenta(on

Dr.FelixSchürmannGeneralProjectManagerBlueBrain/EPFL

Opportuni(esinBiologyattheextremescaleofcompu(ng Aug17‐19,2009

Tissues,OrgansandPhysiologyModeling

Woloschak Lab •  Current Research: (janus.northwestern.edu/wololab): -Studies of radiation on late tissue toxicities including cancer—DOE -Development of nanoparticles for imaging and therapy of cancer—

NCI

•  Challenges/Other areas: -modeling radiation toxicity at the tissue/organism level

(applications to RadOnc) -modeling effects of different radiation qualities (low LET, p+ for

RadOnc; p+, HZE for NASA); modeling interactions of different radiation qualities

-modeling interaction of radiation with other toxicities (chemo for cancer therapy; heavy metals for environmental concerns; others)

-modeling toxicities of various nanoparticles (different materials, sizes, molecules bound, shapes) on tissues, organisms; modeling toxicities of nanoparticles coupled with other materials (applications to nanotech, cancer, therapies, environmental concerns)

-modeling which nanoparticles will be able to accumulate in tissues/tumors due to EPR (enhanced permeability and retention)—(applications to cancer therapy and imaging)