trabajo hipertiroidismo
TRANSCRIPT
KAREN YOLIMA
RONCANCIO ARIAS
III SEMESTRE
INFORMATICA NIVEL
MEDIO
HIPERTIROIDISMO
Es un estado hipermetaboacutelico resultante de exceso de hormona
tiroidea(1)
httpwwwgooglecomcoimagesum=1amphl=esampq=hipertiroidismo20sintomasampie=UTF8ampsource=ogampsa=Namptab=wiampbiw=1024ampbih=573
HORMONA TIROIDEA
Encargada de
bullaumento del metabolismo basal
bullfuncionamiento adecuado de los sistemas cardiovascular musculo
esqueleacutetico y hematopoyeacutetico
bullrespuestas corporales adecuadas en cuanto a
produccioacuten de calor consumo de
oxiacutegeno y regulacioacuten de otros sistemas hormonales
CAUSAS
Enfermedad de GravesBocio toacutexico multinodularNoacutedulo solitario hiperfuncionanteTiroiditis Adenoma toacutexico Hormona tiroidea exoacutegena (iatrogeacutenico o ficticio)Tumor hipofisiario secretor de TSHTumores trofoblaacutesticosCarcinoma folicular del tiroides (metastaacutesico)Tirotoxicosis inducida por yodoResistencia hipofisiaria selectiva a hormona tiroidea Efectos secundarios de ciertos medicamentos (2) httpwwwgooglecomcoimagesum=1amphl=e
sampbiw=1024ampbih=573amptbs=isch3A1ampsa=1ampq=hipertiroidismoampaq=5ampaqi=g10ampaql=ampoq=hip
(3)
SIGNOS Y SINTOMAS
httpbibliotecafucsaludeduco2079ehostresultshid=122ampsid=e4a56fd5-6fec-4ce9-acce-3e707d09a138
bull Temblorbull HiperreflexiabullAnsiedadbullIrritabilidadbullLabilidad emocionalbullAtaques de paacutenicobullIntolerancia al calorbull Aumento del apetitobullDisfuncioacuten menstrual (oligomenorrea amenorrea)(4)
bull El hipertiroidismo afecta a un 2 de las mujeres y el 02 de los hombres en su vida bull bocio multinodular toacutexico por lo general ocurre
en mujeresgt 55 antildeos y es maacutes comuacuten que la enfermedad de Graves en los ancianos
(From Noble J [ed] Textbook of primary care medicine ed 2 St Louis 1996 Mosby
httpbibliotecafucsaludeduco2052booksfiguredofigure=trueampeid=4-u10-B978-0-323-05610-600017-2--f1460ampsectionEid=4-u10-B978-0-323-05610-600017-2--f1470ampisbn=978-0-323-05610-6ampuniqId=235821444-18
httpwwwgooglecomcoimagesum=1amphl=esampbiw=1024ampbih=573amptbs=isch3A1ampsa=1ampq=hipertiroidismoampbtnG=Buscarampaq=fampaqi=g4g-s2g4ampaql=ampoq=
httpwwwmedicina21comdocphpop=enfermedades3ampp=Hampef=Hipertiroidismoampid=1386
httpwwwgooglecomcoimagesum=1amphl=esampq=tratamiento20hipertiroidismoampie=UTF-8ampsource=ogampsa=Namptab=wiampbiw=1024ampbih=573
Tratamiento
BLOQUEADORES BETA
ofrecen alivio raacutepido de los siacutentomas adreneacutergicos de hipertiroidismo como temblor palpitaciones intolerancia al calor y el nerviosismo
YODUROS
bloquean la conversioacuten perifeacuterica de tiroxina (T4) en triyodotironina (T3) e inhiben la liberacioacuten de hormonas Yoduros tambieacuten se utilizan como terapia adyuvante antes de la cirugiacutea de emergencia no tiroideas
ANTITIROIDEOS
actuacutean principalmente al interferir con la organificacioacuten del yodo por lo tanto la supresioacuten de los niveles de hormona tiroidea
YODO RADIOACTIVO
es el tratamiento de eleccioacuten para la mayoriacutea de los pacientes con enfermedad de Graves y bocio nodular toacutexico
CIRUGIacuteA
Una tiroidectomiacutea subtotal se realiza con mayor frecuencia Esta cirugiacutea se conserva parte del tejido de la tiroides y reduce la incidencia de hipotiroidismo a 25 por ciento pero hipertiroidismo persistente o recurrente se produce en un 8 por ciento de los pacientesTiroidectomiacutea total se reserva para pacientes con enfermedad severa o grandes bocios en los que las recurrencias se muy problemaacutetico sino que lleva a un mayor riesgo de hiperparatiroidismo y el dantildeo del nervio lariacutengeo
NUEVAS POSIBILIDADES
Nuevas opciones de tratamiento bajo investigacioacuten incluyen la tiroidectomiacutea subtotal endoscoacutepica la embolizacioacuten de las arterias tiroides la plasmafeacuteresis y la inyeccioacuten percutaacutenea de etanol de toacutexicos noacutedulos de la tiroides (5)
httpwwwgooglecomcoimgresimgurl=httpwwwhealth32comwp-contentuploads201010Methimazole-10-mg-MUTjpgampimgrefurl=httpwwwhealth32comesmethimazoleampusg=__N2S0Cf6MoE4Ja9fPvg5bTiTr3U0=amph=225ampw=300ampsz=19amphl=esampstart=94ampzoom=1amptbnid=JnXgGiaRwrkjRMamptbnh=128amptbnw=179ampei=zphgTaiaPMGp8AalsKSxDAampprev
AbstractBackground Structural details of vertebrate extraocular muscles (EOMs) have shown an anatomically and functionally distinct laminar organization into an outer orbital (OL) and an inner global layer (GL) Since hyperthyroidism alters tissue oxidative metabolism through mitochondrial enzymes it is expected that structuralmitochondrial changes may be seen in hyperthyroid EOMs We investigated the alterations in the laminar organization and mitochondrial changes in hyperthyroid mouse EOMs Methods Hyperthyroidism was induced in C57BL6 mice and fresh rectus muscles were obtained to identify functional mitochondria using MitoTrackerreg Green and confocal microscopy frozen sections from rectus muscles were stained with anti-rabbit Troponin T (selectively present in the OL) to demonstrate changes in the OL and GL of the EOMs Ultrastructuralfeatures of EOMs were studied using transmission electron microscopy (TEM)
RESULTS Of all four rectus EOMs studied the maximum change was seen in the inferior rectus muscle (IR) followed by medial rectus (MR) Myofibercross-sectional area measurements and Troponin T staining in the control IR EOMs demonstrated a smaller OL (1132thinspplusmnthinsp366thinspμm(2)) and higher density staining with Troponin T (90) and a larger GL (411thinspplusmnthinsp1384thinspμm(2)) with low intensity staining (10) while hyperthyroidism resulted in an increased OL (2059thinspplusmnthinsp53thinspμm(2)) and decreased GL (2717 plusmn 75 μm(2)) pthinsp=thinsp0001 Confocal microscopy demonstrated an intense staining especially in the outer rims in the hyperthyroid IR which was confirmed by TEM showing structural alterations in the mitochondria and a subsarcolemmalmigration Conclusions The outer thinner OL of the mouse EOM contains smaller diameter myofibers and fewer mitochondria while the inner larger GL contains larger diameter myofibers and larger density of mitochondria Hyperthyroidism results in a significant alteration in the laminar organization and mitochondrial alterations of mouse EOMs
Effects of hyperthyroidism on the rectus muscles in mice
bullAutores
Nien CJ Jester JV Bose S
bullLink
httpwwwncbinlmnihgovpubmed21212842
Comentario Este articulo es interesante ya que nos habla de la introduccioacuten del
hipertiroidismo en ratones con muacutesculos rectos frescos para poder identificar las mitocondrias funcionales utilizando MitoTracker reg Green y microscopiacutea confocal los cortes congelados de los muacutesculos rectos se tintildeeron con T anti-conejo de troponina (selectivamente en la OC) para poder demostrar cambios en el OC y GL de las misiones de observacioacuten electoral De las cuatro misiones de observacioacuten electoral de los rectos estudiados mostraron el cambio maacuteximo el muacutesculo recto inferior (IR) seguido del recto medial (RM)
AbstractA 63-year-old female was admitted to our hospital with a tender abdominal wall mass about 15 cm in diameter which she had for 1 month About 1 week earlier the patient had also perceived a mass in the neck area Computed tomography revealed huge thyroid and periumbilical masses The thyroid hormone levels were consistent with a hyperthyroid state Pathological examination of the thyroid mass was compatible with anaplastic thyroid carcinoma (ATC) and the abdominal cutaneous mass was shown to be metastatic ATC Despite palliative radiotherapy and chemotherapy the patient died of respiratory failure on her 63rd day of hospitalization This case demonstrates that abdominal cutaneous metastasis and hyperthyroidism can occur as initial manifestations of ATC To our knowledge this is the first reported case
Anaplastic thyroid carcinoma initially presented with abdominal cutaneous mass and hyperthyroidism
bullAutoresLim KH Lee KW Kim JH Park SY Choi SH Lee JS
bullLinkhttpwwwncbinlmnihgovpubmed21179285
Comentario El articulo nos habla de el primer caso reportado por la metaacutestasis
cutaacutenea abdominal y el hipertiroidismo ocurrido por la manifestacioacuten inicial de la ATC en una mujer de 63 antildeos de edad que fue admitida en un hospital con una masa blanda de la pared abdominal de unos 15 cm de diaacutemetro que teniacutea por 1 mes Alrededor de 1 semana antes el paciente habiacutea percibido tambieacuten una misa en la zona del cuello La tomografiacutea computarizada reveloacute enormes masas de tiroides y periumbilical Los niveles de hormonas tiroideas eran compatibles con un estado de hipertiroidismo
1 httpbibliotecafucsaludeduco2052bookspagedoeid=4-u10-B978-0-323-05610-600017-2--s5360ampisbn=978-0-323-05610-6amptype=bookPageampsectionEid=4-u10-B978-0-323-05610-600017-2--s5360ampuniqId=235821444-144-u10-B978-0-323-05610-600017-2--s5360
2httpbibliotecafucsaludeduco2052dasarticlebody2358214449jorg=journalampsource=ampsp=15722101ampsid=0N4923641htmlissn=0002-838X
3 httpbibliotecafucsaludeduco2079ehostimageQuickViewsid=e4a56fd5-6fec-4ce9-acce3e707d09a138sessionmgr114ampvid=11ampui=6634823ampid=39764569ampparentui=39764569amptag=ANampdb=lth
4 httpbibliotecafucsaludeduco2052bookspagedoeid=4-u10-B978-0-323-05610-600017-2--s5360ampisbn=978-0-323-05610-6amptype=bookPageampsectionEid=4-u10-B978-0-323-05610-600017-2--s5360ampuniqId=235821444-144-u10-B978-0-323-05610-600017-2--s5360
5 httpbibliotecafucsaludeduco2052dasarticlebody235821444-14jorg=journalampsource=ampsp=15722101ampsid=0N4923641htmlissn=0002-838X
Bibliografia
Hyperthyroidism Diagnosis and Treatment
American Family Physician - Volume 72 Issue 4 (August 2005) - Copyright copy 2005 American Academy of Family Physicians
Hyperthyroidism in children and adolescents (English) By GODOY C CLAUDIA ACEVEDO M MARCELA BARRERA N ANTONIO YISMEYIAacuteN M ANAHIacute UGARTE P FRANCISCA Revista Chilena de Pediatriacutea enefeb2009 Vol 80 Issue 1 p21-29 9p 2 Charts 2 Graphs Language Spanish (AN 39764569)
httpdecsbvsbrcgi-binwxis1660exedecsserver
wwwmdconsultcom
wwwelseivercom
HIPERTIROIDISMO
Es un estado hipermetaboacutelico resultante de exceso de hormona
tiroidea(1)
httpwwwgooglecomcoimagesum=1amphl=esampq=hipertiroidismo20sintomasampie=UTF8ampsource=ogampsa=Namptab=wiampbiw=1024ampbih=573
HORMONA TIROIDEA
Encargada de
bullaumento del metabolismo basal
bullfuncionamiento adecuado de los sistemas cardiovascular musculo
esqueleacutetico y hematopoyeacutetico
bullrespuestas corporales adecuadas en cuanto a
produccioacuten de calor consumo de
oxiacutegeno y regulacioacuten de otros sistemas hormonales
CAUSAS
Enfermedad de GravesBocio toacutexico multinodularNoacutedulo solitario hiperfuncionanteTiroiditis Adenoma toacutexico Hormona tiroidea exoacutegena (iatrogeacutenico o ficticio)Tumor hipofisiario secretor de TSHTumores trofoblaacutesticosCarcinoma folicular del tiroides (metastaacutesico)Tirotoxicosis inducida por yodoResistencia hipofisiaria selectiva a hormona tiroidea Efectos secundarios de ciertos medicamentos (2) httpwwwgooglecomcoimagesum=1amphl=e
sampbiw=1024ampbih=573amptbs=isch3A1ampsa=1ampq=hipertiroidismoampaq=5ampaqi=g10ampaql=ampoq=hip
(3)
SIGNOS Y SINTOMAS
httpbibliotecafucsaludeduco2079ehostresultshid=122ampsid=e4a56fd5-6fec-4ce9-acce-3e707d09a138
bull Temblorbull HiperreflexiabullAnsiedadbullIrritabilidadbullLabilidad emocionalbullAtaques de paacutenicobullIntolerancia al calorbull Aumento del apetitobullDisfuncioacuten menstrual (oligomenorrea amenorrea)(4)
bull El hipertiroidismo afecta a un 2 de las mujeres y el 02 de los hombres en su vida bull bocio multinodular toacutexico por lo general ocurre
en mujeresgt 55 antildeos y es maacutes comuacuten que la enfermedad de Graves en los ancianos
(From Noble J [ed] Textbook of primary care medicine ed 2 St Louis 1996 Mosby
httpbibliotecafucsaludeduco2052booksfiguredofigure=trueampeid=4-u10-B978-0-323-05610-600017-2--f1460ampsectionEid=4-u10-B978-0-323-05610-600017-2--f1470ampisbn=978-0-323-05610-6ampuniqId=235821444-18
httpwwwgooglecomcoimagesum=1amphl=esampbiw=1024ampbih=573amptbs=isch3A1ampsa=1ampq=hipertiroidismoampbtnG=Buscarampaq=fampaqi=g4g-s2g4ampaql=ampoq=
httpwwwmedicina21comdocphpop=enfermedades3ampp=Hampef=Hipertiroidismoampid=1386
httpwwwgooglecomcoimagesum=1amphl=esampq=tratamiento20hipertiroidismoampie=UTF-8ampsource=ogampsa=Namptab=wiampbiw=1024ampbih=573
Tratamiento
BLOQUEADORES BETA
ofrecen alivio raacutepido de los siacutentomas adreneacutergicos de hipertiroidismo como temblor palpitaciones intolerancia al calor y el nerviosismo
YODUROS
bloquean la conversioacuten perifeacuterica de tiroxina (T4) en triyodotironina (T3) e inhiben la liberacioacuten de hormonas Yoduros tambieacuten se utilizan como terapia adyuvante antes de la cirugiacutea de emergencia no tiroideas
ANTITIROIDEOS
actuacutean principalmente al interferir con la organificacioacuten del yodo por lo tanto la supresioacuten de los niveles de hormona tiroidea
YODO RADIOACTIVO
es el tratamiento de eleccioacuten para la mayoriacutea de los pacientes con enfermedad de Graves y bocio nodular toacutexico
CIRUGIacuteA
Una tiroidectomiacutea subtotal se realiza con mayor frecuencia Esta cirugiacutea se conserva parte del tejido de la tiroides y reduce la incidencia de hipotiroidismo a 25 por ciento pero hipertiroidismo persistente o recurrente se produce en un 8 por ciento de los pacientesTiroidectomiacutea total se reserva para pacientes con enfermedad severa o grandes bocios en los que las recurrencias se muy problemaacutetico sino que lleva a un mayor riesgo de hiperparatiroidismo y el dantildeo del nervio lariacutengeo
NUEVAS POSIBILIDADES
Nuevas opciones de tratamiento bajo investigacioacuten incluyen la tiroidectomiacutea subtotal endoscoacutepica la embolizacioacuten de las arterias tiroides la plasmafeacuteresis y la inyeccioacuten percutaacutenea de etanol de toacutexicos noacutedulos de la tiroides (5)
httpwwwgooglecomcoimgresimgurl=httpwwwhealth32comwp-contentuploads201010Methimazole-10-mg-MUTjpgampimgrefurl=httpwwwhealth32comesmethimazoleampusg=__N2S0Cf6MoE4Ja9fPvg5bTiTr3U0=amph=225ampw=300ampsz=19amphl=esampstart=94ampzoom=1amptbnid=JnXgGiaRwrkjRMamptbnh=128amptbnw=179ampei=zphgTaiaPMGp8AalsKSxDAampprev
AbstractBackground Structural details of vertebrate extraocular muscles (EOMs) have shown an anatomically and functionally distinct laminar organization into an outer orbital (OL) and an inner global layer (GL) Since hyperthyroidism alters tissue oxidative metabolism through mitochondrial enzymes it is expected that structuralmitochondrial changes may be seen in hyperthyroid EOMs We investigated the alterations in the laminar organization and mitochondrial changes in hyperthyroid mouse EOMs Methods Hyperthyroidism was induced in C57BL6 mice and fresh rectus muscles were obtained to identify functional mitochondria using MitoTrackerreg Green and confocal microscopy frozen sections from rectus muscles were stained with anti-rabbit Troponin T (selectively present in the OL) to demonstrate changes in the OL and GL of the EOMs Ultrastructuralfeatures of EOMs were studied using transmission electron microscopy (TEM)
RESULTS Of all four rectus EOMs studied the maximum change was seen in the inferior rectus muscle (IR) followed by medial rectus (MR) Myofibercross-sectional area measurements and Troponin T staining in the control IR EOMs demonstrated a smaller OL (1132thinspplusmnthinsp366thinspμm(2)) and higher density staining with Troponin T (90) and a larger GL (411thinspplusmnthinsp1384thinspμm(2)) with low intensity staining (10) while hyperthyroidism resulted in an increased OL (2059thinspplusmnthinsp53thinspμm(2)) and decreased GL (2717 plusmn 75 μm(2)) pthinsp=thinsp0001 Confocal microscopy demonstrated an intense staining especially in the outer rims in the hyperthyroid IR which was confirmed by TEM showing structural alterations in the mitochondria and a subsarcolemmalmigration Conclusions The outer thinner OL of the mouse EOM contains smaller diameter myofibers and fewer mitochondria while the inner larger GL contains larger diameter myofibers and larger density of mitochondria Hyperthyroidism results in a significant alteration in the laminar organization and mitochondrial alterations of mouse EOMs
Effects of hyperthyroidism on the rectus muscles in mice
bullAutores
Nien CJ Jester JV Bose S
bullLink
httpwwwncbinlmnihgovpubmed21212842
Comentario Este articulo es interesante ya que nos habla de la introduccioacuten del
hipertiroidismo en ratones con muacutesculos rectos frescos para poder identificar las mitocondrias funcionales utilizando MitoTracker reg Green y microscopiacutea confocal los cortes congelados de los muacutesculos rectos se tintildeeron con T anti-conejo de troponina (selectivamente en la OC) para poder demostrar cambios en el OC y GL de las misiones de observacioacuten electoral De las cuatro misiones de observacioacuten electoral de los rectos estudiados mostraron el cambio maacuteximo el muacutesculo recto inferior (IR) seguido del recto medial (RM)
AbstractA 63-year-old female was admitted to our hospital with a tender abdominal wall mass about 15 cm in diameter which she had for 1 month About 1 week earlier the patient had also perceived a mass in the neck area Computed tomography revealed huge thyroid and periumbilical masses The thyroid hormone levels were consistent with a hyperthyroid state Pathological examination of the thyroid mass was compatible with anaplastic thyroid carcinoma (ATC) and the abdominal cutaneous mass was shown to be metastatic ATC Despite palliative radiotherapy and chemotherapy the patient died of respiratory failure on her 63rd day of hospitalization This case demonstrates that abdominal cutaneous metastasis and hyperthyroidism can occur as initial manifestations of ATC To our knowledge this is the first reported case
Anaplastic thyroid carcinoma initially presented with abdominal cutaneous mass and hyperthyroidism
bullAutoresLim KH Lee KW Kim JH Park SY Choi SH Lee JS
bullLinkhttpwwwncbinlmnihgovpubmed21179285
Comentario El articulo nos habla de el primer caso reportado por la metaacutestasis
cutaacutenea abdominal y el hipertiroidismo ocurrido por la manifestacioacuten inicial de la ATC en una mujer de 63 antildeos de edad que fue admitida en un hospital con una masa blanda de la pared abdominal de unos 15 cm de diaacutemetro que teniacutea por 1 mes Alrededor de 1 semana antes el paciente habiacutea percibido tambieacuten una misa en la zona del cuello La tomografiacutea computarizada reveloacute enormes masas de tiroides y periumbilical Los niveles de hormonas tiroideas eran compatibles con un estado de hipertiroidismo
1 httpbibliotecafucsaludeduco2052bookspagedoeid=4-u10-B978-0-323-05610-600017-2--s5360ampisbn=978-0-323-05610-6amptype=bookPageampsectionEid=4-u10-B978-0-323-05610-600017-2--s5360ampuniqId=235821444-144-u10-B978-0-323-05610-600017-2--s5360
2httpbibliotecafucsaludeduco2052dasarticlebody2358214449jorg=journalampsource=ampsp=15722101ampsid=0N4923641htmlissn=0002-838X
3 httpbibliotecafucsaludeduco2079ehostimageQuickViewsid=e4a56fd5-6fec-4ce9-acce3e707d09a138sessionmgr114ampvid=11ampui=6634823ampid=39764569ampparentui=39764569amptag=ANampdb=lth
4 httpbibliotecafucsaludeduco2052bookspagedoeid=4-u10-B978-0-323-05610-600017-2--s5360ampisbn=978-0-323-05610-6amptype=bookPageampsectionEid=4-u10-B978-0-323-05610-600017-2--s5360ampuniqId=235821444-144-u10-B978-0-323-05610-600017-2--s5360
5 httpbibliotecafucsaludeduco2052dasarticlebody235821444-14jorg=journalampsource=ampsp=15722101ampsid=0N4923641htmlissn=0002-838X
Bibliografia
Hyperthyroidism Diagnosis and Treatment
American Family Physician - Volume 72 Issue 4 (August 2005) - Copyright copy 2005 American Academy of Family Physicians
Hyperthyroidism in children and adolescents (English) By GODOY C CLAUDIA ACEVEDO M MARCELA BARRERA N ANTONIO YISMEYIAacuteN M ANAHIacute UGARTE P FRANCISCA Revista Chilena de Pediatriacutea enefeb2009 Vol 80 Issue 1 p21-29 9p 2 Charts 2 Graphs Language Spanish (AN 39764569)
httpdecsbvsbrcgi-binwxis1660exedecsserver
wwwmdconsultcom
wwwelseivercom
HORMONA TIROIDEA
Encargada de
bullaumento del metabolismo basal
bullfuncionamiento adecuado de los sistemas cardiovascular musculo
esqueleacutetico y hematopoyeacutetico
bullrespuestas corporales adecuadas en cuanto a
produccioacuten de calor consumo de
oxiacutegeno y regulacioacuten de otros sistemas hormonales
CAUSAS
Enfermedad de GravesBocio toacutexico multinodularNoacutedulo solitario hiperfuncionanteTiroiditis Adenoma toacutexico Hormona tiroidea exoacutegena (iatrogeacutenico o ficticio)Tumor hipofisiario secretor de TSHTumores trofoblaacutesticosCarcinoma folicular del tiroides (metastaacutesico)Tirotoxicosis inducida por yodoResistencia hipofisiaria selectiva a hormona tiroidea Efectos secundarios de ciertos medicamentos (2) httpwwwgooglecomcoimagesum=1amphl=e
sampbiw=1024ampbih=573amptbs=isch3A1ampsa=1ampq=hipertiroidismoampaq=5ampaqi=g10ampaql=ampoq=hip
(3)
SIGNOS Y SINTOMAS
httpbibliotecafucsaludeduco2079ehostresultshid=122ampsid=e4a56fd5-6fec-4ce9-acce-3e707d09a138
bull Temblorbull HiperreflexiabullAnsiedadbullIrritabilidadbullLabilidad emocionalbullAtaques de paacutenicobullIntolerancia al calorbull Aumento del apetitobullDisfuncioacuten menstrual (oligomenorrea amenorrea)(4)
bull El hipertiroidismo afecta a un 2 de las mujeres y el 02 de los hombres en su vida bull bocio multinodular toacutexico por lo general ocurre
en mujeresgt 55 antildeos y es maacutes comuacuten que la enfermedad de Graves en los ancianos
(From Noble J [ed] Textbook of primary care medicine ed 2 St Louis 1996 Mosby
httpbibliotecafucsaludeduco2052booksfiguredofigure=trueampeid=4-u10-B978-0-323-05610-600017-2--f1460ampsectionEid=4-u10-B978-0-323-05610-600017-2--f1470ampisbn=978-0-323-05610-6ampuniqId=235821444-18
httpwwwgooglecomcoimagesum=1amphl=esampbiw=1024ampbih=573amptbs=isch3A1ampsa=1ampq=hipertiroidismoampbtnG=Buscarampaq=fampaqi=g4g-s2g4ampaql=ampoq=
httpwwwmedicina21comdocphpop=enfermedades3ampp=Hampef=Hipertiroidismoampid=1386
httpwwwgooglecomcoimagesum=1amphl=esampq=tratamiento20hipertiroidismoampie=UTF-8ampsource=ogampsa=Namptab=wiampbiw=1024ampbih=573
Tratamiento
BLOQUEADORES BETA
ofrecen alivio raacutepido de los siacutentomas adreneacutergicos de hipertiroidismo como temblor palpitaciones intolerancia al calor y el nerviosismo
YODUROS
bloquean la conversioacuten perifeacuterica de tiroxina (T4) en triyodotironina (T3) e inhiben la liberacioacuten de hormonas Yoduros tambieacuten se utilizan como terapia adyuvante antes de la cirugiacutea de emergencia no tiroideas
ANTITIROIDEOS
actuacutean principalmente al interferir con la organificacioacuten del yodo por lo tanto la supresioacuten de los niveles de hormona tiroidea
YODO RADIOACTIVO
es el tratamiento de eleccioacuten para la mayoriacutea de los pacientes con enfermedad de Graves y bocio nodular toacutexico
CIRUGIacuteA
Una tiroidectomiacutea subtotal se realiza con mayor frecuencia Esta cirugiacutea se conserva parte del tejido de la tiroides y reduce la incidencia de hipotiroidismo a 25 por ciento pero hipertiroidismo persistente o recurrente se produce en un 8 por ciento de los pacientesTiroidectomiacutea total se reserva para pacientes con enfermedad severa o grandes bocios en los que las recurrencias se muy problemaacutetico sino que lleva a un mayor riesgo de hiperparatiroidismo y el dantildeo del nervio lariacutengeo
NUEVAS POSIBILIDADES
Nuevas opciones de tratamiento bajo investigacioacuten incluyen la tiroidectomiacutea subtotal endoscoacutepica la embolizacioacuten de las arterias tiroides la plasmafeacuteresis y la inyeccioacuten percutaacutenea de etanol de toacutexicos noacutedulos de la tiroides (5)
httpwwwgooglecomcoimgresimgurl=httpwwwhealth32comwp-contentuploads201010Methimazole-10-mg-MUTjpgampimgrefurl=httpwwwhealth32comesmethimazoleampusg=__N2S0Cf6MoE4Ja9fPvg5bTiTr3U0=amph=225ampw=300ampsz=19amphl=esampstart=94ampzoom=1amptbnid=JnXgGiaRwrkjRMamptbnh=128amptbnw=179ampei=zphgTaiaPMGp8AalsKSxDAampprev
AbstractBackground Structural details of vertebrate extraocular muscles (EOMs) have shown an anatomically and functionally distinct laminar organization into an outer orbital (OL) and an inner global layer (GL) Since hyperthyroidism alters tissue oxidative metabolism through mitochondrial enzymes it is expected that structuralmitochondrial changes may be seen in hyperthyroid EOMs We investigated the alterations in the laminar organization and mitochondrial changes in hyperthyroid mouse EOMs Methods Hyperthyroidism was induced in C57BL6 mice and fresh rectus muscles were obtained to identify functional mitochondria using MitoTrackerreg Green and confocal microscopy frozen sections from rectus muscles were stained with anti-rabbit Troponin T (selectively present in the OL) to demonstrate changes in the OL and GL of the EOMs Ultrastructuralfeatures of EOMs were studied using transmission electron microscopy (TEM)
RESULTS Of all four rectus EOMs studied the maximum change was seen in the inferior rectus muscle (IR) followed by medial rectus (MR) Myofibercross-sectional area measurements and Troponin T staining in the control IR EOMs demonstrated a smaller OL (1132thinspplusmnthinsp366thinspμm(2)) and higher density staining with Troponin T (90) and a larger GL (411thinspplusmnthinsp1384thinspμm(2)) with low intensity staining (10) while hyperthyroidism resulted in an increased OL (2059thinspplusmnthinsp53thinspμm(2)) and decreased GL (2717 plusmn 75 μm(2)) pthinsp=thinsp0001 Confocal microscopy demonstrated an intense staining especially in the outer rims in the hyperthyroid IR which was confirmed by TEM showing structural alterations in the mitochondria and a subsarcolemmalmigration Conclusions The outer thinner OL of the mouse EOM contains smaller diameter myofibers and fewer mitochondria while the inner larger GL contains larger diameter myofibers and larger density of mitochondria Hyperthyroidism results in a significant alteration in the laminar organization and mitochondrial alterations of mouse EOMs
Effects of hyperthyroidism on the rectus muscles in mice
bullAutores
Nien CJ Jester JV Bose S
bullLink
httpwwwncbinlmnihgovpubmed21212842
Comentario Este articulo es interesante ya que nos habla de la introduccioacuten del
hipertiroidismo en ratones con muacutesculos rectos frescos para poder identificar las mitocondrias funcionales utilizando MitoTracker reg Green y microscopiacutea confocal los cortes congelados de los muacutesculos rectos se tintildeeron con T anti-conejo de troponina (selectivamente en la OC) para poder demostrar cambios en el OC y GL de las misiones de observacioacuten electoral De las cuatro misiones de observacioacuten electoral de los rectos estudiados mostraron el cambio maacuteximo el muacutesculo recto inferior (IR) seguido del recto medial (RM)
AbstractA 63-year-old female was admitted to our hospital with a tender abdominal wall mass about 15 cm in diameter which she had for 1 month About 1 week earlier the patient had also perceived a mass in the neck area Computed tomography revealed huge thyroid and periumbilical masses The thyroid hormone levels were consistent with a hyperthyroid state Pathological examination of the thyroid mass was compatible with anaplastic thyroid carcinoma (ATC) and the abdominal cutaneous mass was shown to be metastatic ATC Despite palliative radiotherapy and chemotherapy the patient died of respiratory failure on her 63rd day of hospitalization This case demonstrates that abdominal cutaneous metastasis and hyperthyroidism can occur as initial manifestations of ATC To our knowledge this is the first reported case
Anaplastic thyroid carcinoma initially presented with abdominal cutaneous mass and hyperthyroidism
bullAutoresLim KH Lee KW Kim JH Park SY Choi SH Lee JS
bullLinkhttpwwwncbinlmnihgovpubmed21179285
Comentario El articulo nos habla de el primer caso reportado por la metaacutestasis
cutaacutenea abdominal y el hipertiroidismo ocurrido por la manifestacioacuten inicial de la ATC en una mujer de 63 antildeos de edad que fue admitida en un hospital con una masa blanda de la pared abdominal de unos 15 cm de diaacutemetro que teniacutea por 1 mes Alrededor de 1 semana antes el paciente habiacutea percibido tambieacuten una misa en la zona del cuello La tomografiacutea computarizada reveloacute enormes masas de tiroides y periumbilical Los niveles de hormonas tiroideas eran compatibles con un estado de hipertiroidismo
1 httpbibliotecafucsaludeduco2052bookspagedoeid=4-u10-B978-0-323-05610-600017-2--s5360ampisbn=978-0-323-05610-6amptype=bookPageampsectionEid=4-u10-B978-0-323-05610-600017-2--s5360ampuniqId=235821444-144-u10-B978-0-323-05610-600017-2--s5360
2httpbibliotecafucsaludeduco2052dasarticlebody2358214449jorg=journalampsource=ampsp=15722101ampsid=0N4923641htmlissn=0002-838X
3 httpbibliotecafucsaludeduco2079ehostimageQuickViewsid=e4a56fd5-6fec-4ce9-acce3e707d09a138sessionmgr114ampvid=11ampui=6634823ampid=39764569ampparentui=39764569amptag=ANampdb=lth
4 httpbibliotecafucsaludeduco2052bookspagedoeid=4-u10-B978-0-323-05610-600017-2--s5360ampisbn=978-0-323-05610-6amptype=bookPageampsectionEid=4-u10-B978-0-323-05610-600017-2--s5360ampuniqId=235821444-144-u10-B978-0-323-05610-600017-2--s5360
5 httpbibliotecafucsaludeduco2052dasarticlebody235821444-14jorg=journalampsource=ampsp=15722101ampsid=0N4923641htmlissn=0002-838X
Bibliografia
Hyperthyroidism Diagnosis and Treatment
American Family Physician - Volume 72 Issue 4 (August 2005) - Copyright copy 2005 American Academy of Family Physicians
Hyperthyroidism in children and adolescents (English) By GODOY C CLAUDIA ACEVEDO M MARCELA BARRERA N ANTONIO YISMEYIAacuteN M ANAHIacute UGARTE P FRANCISCA Revista Chilena de Pediatriacutea enefeb2009 Vol 80 Issue 1 p21-29 9p 2 Charts 2 Graphs Language Spanish (AN 39764569)
httpdecsbvsbrcgi-binwxis1660exedecsserver
wwwmdconsultcom
wwwelseivercom
CAUSAS
Enfermedad de GravesBocio toacutexico multinodularNoacutedulo solitario hiperfuncionanteTiroiditis Adenoma toacutexico Hormona tiroidea exoacutegena (iatrogeacutenico o ficticio)Tumor hipofisiario secretor de TSHTumores trofoblaacutesticosCarcinoma folicular del tiroides (metastaacutesico)Tirotoxicosis inducida por yodoResistencia hipofisiaria selectiva a hormona tiroidea Efectos secundarios de ciertos medicamentos (2) httpwwwgooglecomcoimagesum=1amphl=e
sampbiw=1024ampbih=573amptbs=isch3A1ampsa=1ampq=hipertiroidismoampaq=5ampaqi=g10ampaql=ampoq=hip
(3)
SIGNOS Y SINTOMAS
httpbibliotecafucsaludeduco2079ehostresultshid=122ampsid=e4a56fd5-6fec-4ce9-acce-3e707d09a138
bull Temblorbull HiperreflexiabullAnsiedadbullIrritabilidadbullLabilidad emocionalbullAtaques de paacutenicobullIntolerancia al calorbull Aumento del apetitobullDisfuncioacuten menstrual (oligomenorrea amenorrea)(4)
bull El hipertiroidismo afecta a un 2 de las mujeres y el 02 de los hombres en su vida bull bocio multinodular toacutexico por lo general ocurre
en mujeresgt 55 antildeos y es maacutes comuacuten que la enfermedad de Graves en los ancianos
(From Noble J [ed] Textbook of primary care medicine ed 2 St Louis 1996 Mosby
httpbibliotecafucsaludeduco2052booksfiguredofigure=trueampeid=4-u10-B978-0-323-05610-600017-2--f1460ampsectionEid=4-u10-B978-0-323-05610-600017-2--f1470ampisbn=978-0-323-05610-6ampuniqId=235821444-18
httpwwwgooglecomcoimagesum=1amphl=esampbiw=1024ampbih=573amptbs=isch3A1ampsa=1ampq=hipertiroidismoampbtnG=Buscarampaq=fampaqi=g4g-s2g4ampaql=ampoq=
httpwwwmedicina21comdocphpop=enfermedades3ampp=Hampef=Hipertiroidismoampid=1386
httpwwwgooglecomcoimagesum=1amphl=esampq=tratamiento20hipertiroidismoampie=UTF-8ampsource=ogampsa=Namptab=wiampbiw=1024ampbih=573
Tratamiento
BLOQUEADORES BETA
ofrecen alivio raacutepido de los siacutentomas adreneacutergicos de hipertiroidismo como temblor palpitaciones intolerancia al calor y el nerviosismo
YODUROS
bloquean la conversioacuten perifeacuterica de tiroxina (T4) en triyodotironina (T3) e inhiben la liberacioacuten de hormonas Yoduros tambieacuten se utilizan como terapia adyuvante antes de la cirugiacutea de emergencia no tiroideas
ANTITIROIDEOS
actuacutean principalmente al interferir con la organificacioacuten del yodo por lo tanto la supresioacuten de los niveles de hormona tiroidea
YODO RADIOACTIVO
es el tratamiento de eleccioacuten para la mayoriacutea de los pacientes con enfermedad de Graves y bocio nodular toacutexico
CIRUGIacuteA
Una tiroidectomiacutea subtotal se realiza con mayor frecuencia Esta cirugiacutea se conserva parte del tejido de la tiroides y reduce la incidencia de hipotiroidismo a 25 por ciento pero hipertiroidismo persistente o recurrente se produce en un 8 por ciento de los pacientesTiroidectomiacutea total se reserva para pacientes con enfermedad severa o grandes bocios en los que las recurrencias se muy problemaacutetico sino que lleva a un mayor riesgo de hiperparatiroidismo y el dantildeo del nervio lariacutengeo
NUEVAS POSIBILIDADES
Nuevas opciones de tratamiento bajo investigacioacuten incluyen la tiroidectomiacutea subtotal endoscoacutepica la embolizacioacuten de las arterias tiroides la plasmafeacuteresis y la inyeccioacuten percutaacutenea de etanol de toacutexicos noacutedulos de la tiroides (5)
httpwwwgooglecomcoimgresimgurl=httpwwwhealth32comwp-contentuploads201010Methimazole-10-mg-MUTjpgampimgrefurl=httpwwwhealth32comesmethimazoleampusg=__N2S0Cf6MoE4Ja9fPvg5bTiTr3U0=amph=225ampw=300ampsz=19amphl=esampstart=94ampzoom=1amptbnid=JnXgGiaRwrkjRMamptbnh=128amptbnw=179ampei=zphgTaiaPMGp8AalsKSxDAampprev
AbstractBackground Structural details of vertebrate extraocular muscles (EOMs) have shown an anatomically and functionally distinct laminar organization into an outer orbital (OL) and an inner global layer (GL) Since hyperthyroidism alters tissue oxidative metabolism through mitochondrial enzymes it is expected that structuralmitochondrial changes may be seen in hyperthyroid EOMs We investigated the alterations in the laminar organization and mitochondrial changes in hyperthyroid mouse EOMs Methods Hyperthyroidism was induced in C57BL6 mice and fresh rectus muscles were obtained to identify functional mitochondria using MitoTrackerreg Green and confocal microscopy frozen sections from rectus muscles were stained with anti-rabbit Troponin T (selectively present in the OL) to demonstrate changes in the OL and GL of the EOMs Ultrastructuralfeatures of EOMs were studied using transmission electron microscopy (TEM)
RESULTS Of all four rectus EOMs studied the maximum change was seen in the inferior rectus muscle (IR) followed by medial rectus (MR) Myofibercross-sectional area measurements and Troponin T staining in the control IR EOMs demonstrated a smaller OL (1132thinspplusmnthinsp366thinspμm(2)) and higher density staining with Troponin T (90) and a larger GL (411thinspplusmnthinsp1384thinspμm(2)) with low intensity staining (10) while hyperthyroidism resulted in an increased OL (2059thinspplusmnthinsp53thinspμm(2)) and decreased GL (2717 plusmn 75 μm(2)) pthinsp=thinsp0001 Confocal microscopy demonstrated an intense staining especially in the outer rims in the hyperthyroid IR which was confirmed by TEM showing structural alterations in the mitochondria and a subsarcolemmalmigration Conclusions The outer thinner OL of the mouse EOM contains smaller diameter myofibers and fewer mitochondria while the inner larger GL contains larger diameter myofibers and larger density of mitochondria Hyperthyroidism results in a significant alteration in the laminar organization and mitochondrial alterations of mouse EOMs
Effects of hyperthyroidism on the rectus muscles in mice
bullAutores
Nien CJ Jester JV Bose S
bullLink
httpwwwncbinlmnihgovpubmed21212842
Comentario Este articulo es interesante ya que nos habla de la introduccioacuten del
hipertiroidismo en ratones con muacutesculos rectos frescos para poder identificar las mitocondrias funcionales utilizando MitoTracker reg Green y microscopiacutea confocal los cortes congelados de los muacutesculos rectos se tintildeeron con T anti-conejo de troponina (selectivamente en la OC) para poder demostrar cambios en el OC y GL de las misiones de observacioacuten electoral De las cuatro misiones de observacioacuten electoral de los rectos estudiados mostraron el cambio maacuteximo el muacutesculo recto inferior (IR) seguido del recto medial (RM)
AbstractA 63-year-old female was admitted to our hospital with a tender abdominal wall mass about 15 cm in diameter which she had for 1 month About 1 week earlier the patient had also perceived a mass in the neck area Computed tomography revealed huge thyroid and periumbilical masses The thyroid hormone levels were consistent with a hyperthyroid state Pathological examination of the thyroid mass was compatible with anaplastic thyroid carcinoma (ATC) and the abdominal cutaneous mass was shown to be metastatic ATC Despite palliative radiotherapy and chemotherapy the patient died of respiratory failure on her 63rd day of hospitalization This case demonstrates that abdominal cutaneous metastasis and hyperthyroidism can occur as initial manifestations of ATC To our knowledge this is the first reported case
Anaplastic thyroid carcinoma initially presented with abdominal cutaneous mass and hyperthyroidism
bullAutoresLim KH Lee KW Kim JH Park SY Choi SH Lee JS
bullLinkhttpwwwncbinlmnihgovpubmed21179285
Comentario El articulo nos habla de el primer caso reportado por la metaacutestasis
cutaacutenea abdominal y el hipertiroidismo ocurrido por la manifestacioacuten inicial de la ATC en una mujer de 63 antildeos de edad que fue admitida en un hospital con una masa blanda de la pared abdominal de unos 15 cm de diaacutemetro que teniacutea por 1 mes Alrededor de 1 semana antes el paciente habiacutea percibido tambieacuten una misa en la zona del cuello La tomografiacutea computarizada reveloacute enormes masas de tiroides y periumbilical Los niveles de hormonas tiroideas eran compatibles con un estado de hipertiroidismo
1 httpbibliotecafucsaludeduco2052bookspagedoeid=4-u10-B978-0-323-05610-600017-2--s5360ampisbn=978-0-323-05610-6amptype=bookPageampsectionEid=4-u10-B978-0-323-05610-600017-2--s5360ampuniqId=235821444-144-u10-B978-0-323-05610-600017-2--s5360
2httpbibliotecafucsaludeduco2052dasarticlebody2358214449jorg=journalampsource=ampsp=15722101ampsid=0N4923641htmlissn=0002-838X
3 httpbibliotecafucsaludeduco2079ehostimageQuickViewsid=e4a56fd5-6fec-4ce9-acce3e707d09a138sessionmgr114ampvid=11ampui=6634823ampid=39764569ampparentui=39764569amptag=ANampdb=lth
4 httpbibliotecafucsaludeduco2052bookspagedoeid=4-u10-B978-0-323-05610-600017-2--s5360ampisbn=978-0-323-05610-6amptype=bookPageampsectionEid=4-u10-B978-0-323-05610-600017-2--s5360ampuniqId=235821444-144-u10-B978-0-323-05610-600017-2--s5360
5 httpbibliotecafucsaludeduco2052dasarticlebody235821444-14jorg=journalampsource=ampsp=15722101ampsid=0N4923641htmlissn=0002-838X
Bibliografia
Hyperthyroidism Diagnosis and Treatment
American Family Physician - Volume 72 Issue 4 (August 2005) - Copyright copy 2005 American Academy of Family Physicians
Hyperthyroidism in children and adolescents (English) By GODOY C CLAUDIA ACEVEDO M MARCELA BARRERA N ANTONIO YISMEYIAacuteN M ANAHIacute UGARTE P FRANCISCA Revista Chilena de Pediatriacutea enefeb2009 Vol 80 Issue 1 p21-29 9p 2 Charts 2 Graphs Language Spanish (AN 39764569)
httpdecsbvsbrcgi-binwxis1660exedecsserver
wwwmdconsultcom
wwwelseivercom
(3)
SIGNOS Y SINTOMAS
httpbibliotecafucsaludeduco2079ehostresultshid=122ampsid=e4a56fd5-6fec-4ce9-acce-3e707d09a138
bull Temblorbull HiperreflexiabullAnsiedadbullIrritabilidadbullLabilidad emocionalbullAtaques de paacutenicobullIntolerancia al calorbull Aumento del apetitobullDisfuncioacuten menstrual (oligomenorrea amenorrea)(4)
bull El hipertiroidismo afecta a un 2 de las mujeres y el 02 de los hombres en su vida bull bocio multinodular toacutexico por lo general ocurre
en mujeresgt 55 antildeos y es maacutes comuacuten que la enfermedad de Graves en los ancianos
(From Noble J [ed] Textbook of primary care medicine ed 2 St Louis 1996 Mosby
httpbibliotecafucsaludeduco2052booksfiguredofigure=trueampeid=4-u10-B978-0-323-05610-600017-2--f1460ampsectionEid=4-u10-B978-0-323-05610-600017-2--f1470ampisbn=978-0-323-05610-6ampuniqId=235821444-18
httpwwwgooglecomcoimagesum=1amphl=esampbiw=1024ampbih=573amptbs=isch3A1ampsa=1ampq=hipertiroidismoampbtnG=Buscarampaq=fampaqi=g4g-s2g4ampaql=ampoq=
httpwwwmedicina21comdocphpop=enfermedades3ampp=Hampef=Hipertiroidismoampid=1386
httpwwwgooglecomcoimagesum=1amphl=esampq=tratamiento20hipertiroidismoampie=UTF-8ampsource=ogampsa=Namptab=wiampbiw=1024ampbih=573
Tratamiento
BLOQUEADORES BETA
ofrecen alivio raacutepido de los siacutentomas adreneacutergicos de hipertiroidismo como temblor palpitaciones intolerancia al calor y el nerviosismo
YODUROS
bloquean la conversioacuten perifeacuterica de tiroxina (T4) en triyodotironina (T3) e inhiben la liberacioacuten de hormonas Yoduros tambieacuten se utilizan como terapia adyuvante antes de la cirugiacutea de emergencia no tiroideas
ANTITIROIDEOS
actuacutean principalmente al interferir con la organificacioacuten del yodo por lo tanto la supresioacuten de los niveles de hormona tiroidea
YODO RADIOACTIVO
es el tratamiento de eleccioacuten para la mayoriacutea de los pacientes con enfermedad de Graves y bocio nodular toacutexico
CIRUGIacuteA
Una tiroidectomiacutea subtotal se realiza con mayor frecuencia Esta cirugiacutea se conserva parte del tejido de la tiroides y reduce la incidencia de hipotiroidismo a 25 por ciento pero hipertiroidismo persistente o recurrente se produce en un 8 por ciento de los pacientesTiroidectomiacutea total se reserva para pacientes con enfermedad severa o grandes bocios en los que las recurrencias se muy problemaacutetico sino que lleva a un mayor riesgo de hiperparatiroidismo y el dantildeo del nervio lariacutengeo
NUEVAS POSIBILIDADES
Nuevas opciones de tratamiento bajo investigacioacuten incluyen la tiroidectomiacutea subtotal endoscoacutepica la embolizacioacuten de las arterias tiroides la plasmafeacuteresis y la inyeccioacuten percutaacutenea de etanol de toacutexicos noacutedulos de la tiroides (5)
httpwwwgooglecomcoimgresimgurl=httpwwwhealth32comwp-contentuploads201010Methimazole-10-mg-MUTjpgampimgrefurl=httpwwwhealth32comesmethimazoleampusg=__N2S0Cf6MoE4Ja9fPvg5bTiTr3U0=amph=225ampw=300ampsz=19amphl=esampstart=94ampzoom=1amptbnid=JnXgGiaRwrkjRMamptbnh=128amptbnw=179ampei=zphgTaiaPMGp8AalsKSxDAampprev
AbstractBackground Structural details of vertebrate extraocular muscles (EOMs) have shown an anatomically and functionally distinct laminar organization into an outer orbital (OL) and an inner global layer (GL) Since hyperthyroidism alters tissue oxidative metabolism through mitochondrial enzymes it is expected that structuralmitochondrial changes may be seen in hyperthyroid EOMs We investigated the alterations in the laminar organization and mitochondrial changes in hyperthyroid mouse EOMs Methods Hyperthyroidism was induced in C57BL6 mice and fresh rectus muscles were obtained to identify functional mitochondria using MitoTrackerreg Green and confocal microscopy frozen sections from rectus muscles were stained with anti-rabbit Troponin T (selectively present in the OL) to demonstrate changes in the OL and GL of the EOMs Ultrastructuralfeatures of EOMs were studied using transmission electron microscopy (TEM)
RESULTS Of all four rectus EOMs studied the maximum change was seen in the inferior rectus muscle (IR) followed by medial rectus (MR) Myofibercross-sectional area measurements and Troponin T staining in the control IR EOMs demonstrated a smaller OL (1132thinspplusmnthinsp366thinspμm(2)) and higher density staining with Troponin T (90) and a larger GL (411thinspplusmnthinsp1384thinspμm(2)) with low intensity staining (10) while hyperthyroidism resulted in an increased OL (2059thinspplusmnthinsp53thinspμm(2)) and decreased GL (2717 plusmn 75 μm(2)) pthinsp=thinsp0001 Confocal microscopy demonstrated an intense staining especially in the outer rims in the hyperthyroid IR which was confirmed by TEM showing structural alterations in the mitochondria and a subsarcolemmalmigration Conclusions The outer thinner OL of the mouse EOM contains smaller diameter myofibers and fewer mitochondria while the inner larger GL contains larger diameter myofibers and larger density of mitochondria Hyperthyroidism results in a significant alteration in the laminar organization and mitochondrial alterations of mouse EOMs
Effects of hyperthyroidism on the rectus muscles in mice
bullAutores
Nien CJ Jester JV Bose S
bullLink
httpwwwncbinlmnihgovpubmed21212842
Comentario Este articulo es interesante ya que nos habla de la introduccioacuten del
hipertiroidismo en ratones con muacutesculos rectos frescos para poder identificar las mitocondrias funcionales utilizando MitoTracker reg Green y microscopiacutea confocal los cortes congelados de los muacutesculos rectos se tintildeeron con T anti-conejo de troponina (selectivamente en la OC) para poder demostrar cambios en el OC y GL de las misiones de observacioacuten electoral De las cuatro misiones de observacioacuten electoral de los rectos estudiados mostraron el cambio maacuteximo el muacutesculo recto inferior (IR) seguido del recto medial (RM)
AbstractA 63-year-old female was admitted to our hospital with a tender abdominal wall mass about 15 cm in diameter which she had for 1 month About 1 week earlier the patient had also perceived a mass in the neck area Computed tomography revealed huge thyroid and periumbilical masses The thyroid hormone levels were consistent with a hyperthyroid state Pathological examination of the thyroid mass was compatible with anaplastic thyroid carcinoma (ATC) and the abdominal cutaneous mass was shown to be metastatic ATC Despite palliative radiotherapy and chemotherapy the patient died of respiratory failure on her 63rd day of hospitalization This case demonstrates that abdominal cutaneous metastasis and hyperthyroidism can occur as initial manifestations of ATC To our knowledge this is the first reported case
Anaplastic thyroid carcinoma initially presented with abdominal cutaneous mass and hyperthyroidism
bullAutoresLim KH Lee KW Kim JH Park SY Choi SH Lee JS
bullLinkhttpwwwncbinlmnihgovpubmed21179285
Comentario El articulo nos habla de el primer caso reportado por la metaacutestasis
cutaacutenea abdominal y el hipertiroidismo ocurrido por la manifestacioacuten inicial de la ATC en una mujer de 63 antildeos de edad que fue admitida en un hospital con una masa blanda de la pared abdominal de unos 15 cm de diaacutemetro que teniacutea por 1 mes Alrededor de 1 semana antes el paciente habiacutea percibido tambieacuten una misa en la zona del cuello La tomografiacutea computarizada reveloacute enormes masas de tiroides y periumbilical Los niveles de hormonas tiroideas eran compatibles con un estado de hipertiroidismo
1 httpbibliotecafucsaludeduco2052bookspagedoeid=4-u10-B978-0-323-05610-600017-2--s5360ampisbn=978-0-323-05610-6amptype=bookPageampsectionEid=4-u10-B978-0-323-05610-600017-2--s5360ampuniqId=235821444-144-u10-B978-0-323-05610-600017-2--s5360
2httpbibliotecafucsaludeduco2052dasarticlebody2358214449jorg=journalampsource=ampsp=15722101ampsid=0N4923641htmlissn=0002-838X
3 httpbibliotecafucsaludeduco2079ehostimageQuickViewsid=e4a56fd5-6fec-4ce9-acce3e707d09a138sessionmgr114ampvid=11ampui=6634823ampid=39764569ampparentui=39764569amptag=ANampdb=lth
4 httpbibliotecafucsaludeduco2052bookspagedoeid=4-u10-B978-0-323-05610-600017-2--s5360ampisbn=978-0-323-05610-6amptype=bookPageampsectionEid=4-u10-B978-0-323-05610-600017-2--s5360ampuniqId=235821444-144-u10-B978-0-323-05610-600017-2--s5360
5 httpbibliotecafucsaludeduco2052dasarticlebody235821444-14jorg=journalampsource=ampsp=15722101ampsid=0N4923641htmlissn=0002-838X
Bibliografia
Hyperthyroidism Diagnosis and Treatment
American Family Physician - Volume 72 Issue 4 (August 2005) - Copyright copy 2005 American Academy of Family Physicians
Hyperthyroidism in children and adolescents (English) By GODOY C CLAUDIA ACEVEDO M MARCELA BARRERA N ANTONIO YISMEYIAacuteN M ANAHIacute UGARTE P FRANCISCA Revista Chilena de Pediatriacutea enefeb2009 Vol 80 Issue 1 p21-29 9p 2 Charts 2 Graphs Language Spanish (AN 39764569)
httpdecsbvsbrcgi-binwxis1660exedecsserver
wwwmdconsultcom
wwwelseivercom
bull Temblorbull HiperreflexiabullAnsiedadbullIrritabilidadbullLabilidad emocionalbullAtaques de paacutenicobullIntolerancia al calorbull Aumento del apetitobullDisfuncioacuten menstrual (oligomenorrea amenorrea)(4)
bull El hipertiroidismo afecta a un 2 de las mujeres y el 02 de los hombres en su vida bull bocio multinodular toacutexico por lo general ocurre
en mujeresgt 55 antildeos y es maacutes comuacuten que la enfermedad de Graves en los ancianos
(From Noble J [ed] Textbook of primary care medicine ed 2 St Louis 1996 Mosby
httpbibliotecafucsaludeduco2052booksfiguredofigure=trueampeid=4-u10-B978-0-323-05610-600017-2--f1460ampsectionEid=4-u10-B978-0-323-05610-600017-2--f1470ampisbn=978-0-323-05610-6ampuniqId=235821444-18
httpwwwgooglecomcoimagesum=1amphl=esampbiw=1024ampbih=573amptbs=isch3A1ampsa=1ampq=hipertiroidismoampbtnG=Buscarampaq=fampaqi=g4g-s2g4ampaql=ampoq=
httpwwwmedicina21comdocphpop=enfermedades3ampp=Hampef=Hipertiroidismoampid=1386
httpwwwgooglecomcoimagesum=1amphl=esampq=tratamiento20hipertiroidismoampie=UTF-8ampsource=ogampsa=Namptab=wiampbiw=1024ampbih=573
Tratamiento
BLOQUEADORES BETA
ofrecen alivio raacutepido de los siacutentomas adreneacutergicos de hipertiroidismo como temblor palpitaciones intolerancia al calor y el nerviosismo
YODUROS
bloquean la conversioacuten perifeacuterica de tiroxina (T4) en triyodotironina (T3) e inhiben la liberacioacuten de hormonas Yoduros tambieacuten se utilizan como terapia adyuvante antes de la cirugiacutea de emergencia no tiroideas
ANTITIROIDEOS
actuacutean principalmente al interferir con la organificacioacuten del yodo por lo tanto la supresioacuten de los niveles de hormona tiroidea
YODO RADIOACTIVO
es el tratamiento de eleccioacuten para la mayoriacutea de los pacientes con enfermedad de Graves y bocio nodular toacutexico
CIRUGIacuteA
Una tiroidectomiacutea subtotal se realiza con mayor frecuencia Esta cirugiacutea se conserva parte del tejido de la tiroides y reduce la incidencia de hipotiroidismo a 25 por ciento pero hipertiroidismo persistente o recurrente se produce en un 8 por ciento de los pacientesTiroidectomiacutea total se reserva para pacientes con enfermedad severa o grandes bocios en los que las recurrencias se muy problemaacutetico sino que lleva a un mayor riesgo de hiperparatiroidismo y el dantildeo del nervio lariacutengeo
NUEVAS POSIBILIDADES
Nuevas opciones de tratamiento bajo investigacioacuten incluyen la tiroidectomiacutea subtotal endoscoacutepica la embolizacioacuten de las arterias tiroides la plasmafeacuteresis y la inyeccioacuten percutaacutenea de etanol de toacutexicos noacutedulos de la tiroides (5)
httpwwwgooglecomcoimgresimgurl=httpwwwhealth32comwp-contentuploads201010Methimazole-10-mg-MUTjpgampimgrefurl=httpwwwhealth32comesmethimazoleampusg=__N2S0Cf6MoE4Ja9fPvg5bTiTr3U0=amph=225ampw=300ampsz=19amphl=esampstart=94ampzoom=1amptbnid=JnXgGiaRwrkjRMamptbnh=128amptbnw=179ampei=zphgTaiaPMGp8AalsKSxDAampprev
AbstractBackground Structural details of vertebrate extraocular muscles (EOMs) have shown an anatomically and functionally distinct laminar organization into an outer orbital (OL) and an inner global layer (GL) Since hyperthyroidism alters tissue oxidative metabolism through mitochondrial enzymes it is expected that structuralmitochondrial changes may be seen in hyperthyroid EOMs We investigated the alterations in the laminar organization and mitochondrial changes in hyperthyroid mouse EOMs Methods Hyperthyroidism was induced in C57BL6 mice and fresh rectus muscles were obtained to identify functional mitochondria using MitoTrackerreg Green and confocal microscopy frozen sections from rectus muscles were stained with anti-rabbit Troponin T (selectively present in the OL) to demonstrate changes in the OL and GL of the EOMs Ultrastructuralfeatures of EOMs were studied using transmission electron microscopy (TEM)
RESULTS Of all four rectus EOMs studied the maximum change was seen in the inferior rectus muscle (IR) followed by medial rectus (MR) Myofibercross-sectional area measurements and Troponin T staining in the control IR EOMs demonstrated a smaller OL (1132thinspplusmnthinsp366thinspμm(2)) and higher density staining with Troponin T (90) and a larger GL (411thinspplusmnthinsp1384thinspμm(2)) with low intensity staining (10) while hyperthyroidism resulted in an increased OL (2059thinspplusmnthinsp53thinspμm(2)) and decreased GL (2717 plusmn 75 μm(2)) pthinsp=thinsp0001 Confocal microscopy demonstrated an intense staining especially in the outer rims in the hyperthyroid IR which was confirmed by TEM showing structural alterations in the mitochondria and a subsarcolemmalmigration Conclusions The outer thinner OL of the mouse EOM contains smaller diameter myofibers and fewer mitochondria while the inner larger GL contains larger diameter myofibers and larger density of mitochondria Hyperthyroidism results in a significant alteration in the laminar organization and mitochondrial alterations of mouse EOMs
Effects of hyperthyroidism on the rectus muscles in mice
bullAutores
Nien CJ Jester JV Bose S
bullLink
httpwwwncbinlmnihgovpubmed21212842
Comentario Este articulo es interesante ya que nos habla de la introduccioacuten del
hipertiroidismo en ratones con muacutesculos rectos frescos para poder identificar las mitocondrias funcionales utilizando MitoTracker reg Green y microscopiacutea confocal los cortes congelados de los muacutesculos rectos se tintildeeron con T anti-conejo de troponina (selectivamente en la OC) para poder demostrar cambios en el OC y GL de las misiones de observacioacuten electoral De las cuatro misiones de observacioacuten electoral de los rectos estudiados mostraron el cambio maacuteximo el muacutesculo recto inferior (IR) seguido del recto medial (RM)
AbstractA 63-year-old female was admitted to our hospital with a tender abdominal wall mass about 15 cm in diameter which she had for 1 month About 1 week earlier the patient had also perceived a mass in the neck area Computed tomography revealed huge thyroid and periumbilical masses The thyroid hormone levels were consistent with a hyperthyroid state Pathological examination of the thyroid mass was compatible with anaplastic thyroid carcinoma (ATC) and the abdominal cutaneous mass was shown to be metastatic ATC Despite palliative radiotherapy and chemotherapy the patient died of respiratory failure on her 63rd day of hospitalization This case demonstrates that abdominal cutaneous metastasis and hyperthyroidism can occur as initial manifestations of ATC To our knowledge this is the first reported case
Anaplastic thyroid carcinoma initially presented with abdominal cutaneous mass and hyperthyroidism
bullAutoresLim KH Lee KW Kim JH Park SY Choi SH Lee JS
bullLinkhttpwwwncbinlmnihgovpubmed21179285
Comentario El articulo nos habla de el primer caso reportado por la metaacutestasis
cutaacutenea abdominal y el hipertiroidismo ocurrido por la manifestacioacuten inicial de la ATC en una mujer de 63 antildeos de edad que fue admitida en un hospital con una masa blanda de la pared abdominal de unos 15 cm de diaacutemetro que teniacutea por 1 mes Alrededor de 1 semana antes el paciente habiacutea percibido tambieacuten una misa en la zona del cuello La tomografiacutea computarizada reveloacute enormes masas de tiroides y periumbilical Los niveles de hormonas tiroideas eran compatibles con un estado de hipertiroidismo
1 httpbibliotecafucsaludeduco2052bookspagedoeid=4-u10-B978-0-323-05610-600017-2--s5360ampisbn=978-0-323-05610-6amptype=bookPageampsectionEid=4-u10-B978-0-323-05610-600017-2--s5360ampuniqId=235821444-144-u10-B978-0-323-05610-600017-2--s5360
2httpbibliotecafucsaludeduco2052dasarticlebody2358214449jorg=journalampsource=ampsp=15722101ampsid=0N4923641htmlissn=0002-838X
3 httpbibliotecafucsaludeduco2079ehostimageQuickViewsid=e4a56fd5-6fec-4ce9-acce3e707d09a138sessionmgr114ampvid=11ampui=6634823ampid=39764569ampparentui=39764569amptag=ANampdb=lth
4 httpbibliotecafucsaludeduco2052bookspagedoeid=4-u10-B978-0-323-05610-600017-2--s5360ampisbn=978-0-323-05610-6amptype=bookPageampsectionEid=4-u10-B978-0-323-05610-600017-2--s5360ampuniqId=235821444-144-u10-B978-0-323-05610-600017-2--s5360
5 httpbibliotecafucsaludeduco2052dasarticlebody235821444-14jorg=journalampsource=ampsp=15722101ampsid=0N4923641htmlissn=0002-838X
Bibliografia
Hyperthyroidism Diagnosis and Treatment
American Family Physician - Volume 72 Issue 4 (August 2005) - Copyright copy 2005 American Academy of Family Physicians
Hyperthyroidism in children and adolescents (English) By GODOY C CLAUDIA ACEVEDO M MARCELA BARRERA N ANTONIO YISMEYIAacuteN M ANAHIacute UGARTE P FRANCISCA Revista Chilena de Pediatriacutea enefeb2009 Vol 80 Issue 1 p21-29 9p 2 Charts 2 Graphs Language Spanish (AN 39764569)
httpdecsbvsbrcgi-binwxis1660exedecsserver
wwwmdconsultcom
wwwelseivercom
(From Noble J [ed] Textbook of primary care medicine ed 2 St Louis 1996 Mosby
httpbibliotecafucsaludeduco2052booksfiguredofigure=trueampeid=4-u10-B978-0-323-05610-600017-2--f1460ampsectionEid=4-u10-B978-0-323-05610-600017-2--f1470ampisbn=978-0-323-05610-6ampuniqId=235821444-18
httpwwwgooglecomcoimagesum=1amphl=esampbiw=1024ampbih=573amptbs=isch3A1ampsa=1ampq=hipertiroidismoampbtnG=Buscarampaq=fampaqi=g4g-s2g4ampaql=ampoq=
httpwwwmedicina21comdocphpop=enfermedades3ampp=Hampef=Hipertiroidismoampid=1386
httpwwwgooglecomcoimagesum=1amphl=esampq=tratamiento20hipertiroidismoampie=UTF-8ampsource=ogampsa=Namptab=wiampbiw=1024ampbih=573
Tratamiento
BLOQUEADORES BETA
ofrecen alivio raacutepido de los siacutentomas adreneacutergicos de hipertiroidismo como temblor palpitaciones intolerancia al calor y el nerviosismo
YODUROS
bloquean la conversioacuten perifeacuterica de tiroxina (T4) en triyodotironina (T3) e inhiben la liberacioacuten de hormonas Yoduros tambieacuten se utilizan como terapia adyuvante antes de la cirugiacutea de emergencia no tiroideas
ANTITIROIDEOS
actuacutean principalmente al interferir con la organificacioacuten del yodo por lo tanto la supresioacuten de los niveles de hormona tiroidea
YODO RADIOACTIVO
es el tratamiento de eleccioacuten para la mayoriacutea de los pacientes con enfermedad de Graves y bocio nodular toacutexico
CIRUGIacuteA
Una tiroidectomiacutea subtotal se realiza con mayor frecuencia Esta cirugiacutea se conserva parte del tejido de la tiroides y reduce la incidencia de hipotiroidismo a 25 por ciento pero hipertiroidismo persistente o recurrente se produce en un 8 por ciento de los pacientesTiroidectomiacutea total se reserva para pacientes con enfermedad severa o grandes bocios en los que las recurrencias se muy problemaacutetico sino que lleva a un mayor riesgo de hiperparatiroidismo y el dantildeo del nervio lariacutengeo
NUEVAS POSIBILIDADES
Nuevas opciones de tratamiento bajo investigacioacuten incluyen la tiroidectomiacutea subtotal endoscoacutepica la embolizacioacuten de las arterias tiroides la plasmafeacuteresis y la inyeccioacuten percutaacutenea de etanol de toacutexicos noacutedulos de la tiroides (5)
httpwwwgooglecomcoimgresimgurl=httpwwwhealth32comwp-contentuploads201010Methimazole-10-mg-MUTjpgampimgrefurl=httpwwwhealth32comesmethimazoleampusg=__N2S0Cf6MoE4Ja9fPvg5bTiTr3U0=amph=225ampw=300ampsz=19amphl=esampstart=94ampzoom=1amptbnid=JnXgGiaRwrkjRMamptbnh=128amptbnw=179ampei=zphgTaiaPMGp8AalsKSxDAampprev
AbstractBackground Structural details of vertebrate extraocular muscles (EOMs) have shown an anatomically and functionally distinct laminar organization into an outer orbital (OL) and an inner global layer (GL) Since hyperthyroidism alters tissue oxidative metabolism through mitochondrial enzymes it is expected that structuralmitochondrial changes may be seen in hyperthyroid EOMs We investigated the alterations in the laminar organization and mitochondrial changes in hyperthyroid mouse EOMs Methods Hyperthyroidism was induced in C57BL6 mice and fresh rectus muscles were obtained to identify functional mitochondria using MitoTrackerreg Green and confocal microscopy frozen sections from rectus muscles were stained with anti-rabbit Troponin T (selectively present in the OL) to demonstrate changes in the OL and GL of the EOMs Ultrastructuralfeatures of EOMs were studied using transmission electron microscopy (TEM)
RESULTS Of all four rectus EOMs studied the maximum change was seen in the inferior rectus muscle (IR) followed by medial rectus (MR) Myofibercross-sectional area measurements and Troponin T staining in the control IR EOMs demonstrated a smaller OL (1132thinspplusmnthinsp366thinspμm(2)) and higher density staining with Troponin T (90) and a larger GL (411thinspplusmnthinsp1384thinspμm(2)) with low intensity staining (10) while hyperthyroidism resulted in an increased OL (2059thinspplusmnthinsp53thinspμm(2)) and decreased GL (2717 plusmn 75 μm(2)) pthinsp=thinsp0001 Confocal microscopy demonstrated an intense staining especially in the outer rims in the hyperthyroid IR which was confirmed by TEM showing structural alterations in the mitochondria and a subsarcolemmalmigration Conclusions The outer thinner OL of the mouse EOM contains smaller diameter myofibers and fewer mitochondria while the inner larger GL contains larger diameter myofibers and larger density of mitochondria Hyperthyroidism results in a significant alteration in the laminar organization and mitochondrial alterations of mouse EOMs
Effects of hyperthyroidism on the rectus muscles in mice
bullAutores
Nien CJ Jester JV Bose S
bullLink
httpwwwncbinlmnihgovpubmed21212842
Comentario Este articulo es interesante ya que nos habla de la introduccioacuten del
hipertiroidismo en ratones con muacutesculos rectos frescos para poder identificar las mitocondrias funcionales utilizando MitoTracker reg Green y microscopiacutea confocal los cortes congelados de los muacutesculos rectos se tintildeeron con T anti-conejo de troponina (selectivamente en la OC) para poder demostrar cambios en el OC y GL de las misiones de observacioacuten electoral De las cuatro misiones de observacioacuten electoral de los rectos estudiados mostraron el cambio maacuteximo el muacutesculo recto inferior (IR) seguido del recto medial (RM)
AbstractA 63-year-old female was admitted to our hospital with a tender abdominal wall mass about 15 cm in diameter which she had for 1 month About 1 week earlier the patient had also perceived a mass in the neck area Computed tomography revealed huge thyroid and periumbilical masses The thyroid hormone levels were consistent with a hyperthyroid state Pathological examination of the thyroid mass was compatible with anaplastic thyroid carcinoma (ATC) and the abdominal cutaneous mass was shown to be metastatic ATC Despite palliative radiotherapy and chemotherapy the patient died of respiratory failure on her 63rd day of hospitalization This case demonstrates that abdominal cutaneous metastasis and hyperthyroidism can occur as initial manifestations of ATC To our knowledge this is the first reported case
Anaplastic thyroid carcinoma initially presented with abdominal cutaneous mass and hyperthyroidism
bullAutoresLim KH Lee KW Kim JH Park SY Choi SH Lee JS
bullLinkhttpwwwncbinlmnihgovpubmed21179285
Comentario El articulo nos habla de el primer caso reportado por la metaacutestasis
cutaacutenea abdominal y el hipertiroidismo ocurrido por la manifestacioacuten inicial de la ATC en una mujer de 63 antildeos de edad que fue admitida en un hospital con una masa blanda de la pared abdominal de unos 15 cm de diaacutemetro que teniacutea por 1 mes Alrededor de 1 semana antes el paciente habiacutea percibido tambieacuten una misa en la zona del cuello La tomografiacutea computarizada reveloacute enormes masas de tiroides y periumbilical Los niveles de hormonas tiroideas eran compatibles con un estado de hipertiroidismo
1 httpbibliotecafucsaludeduco2052bookspagedoeid=4-u10-B978-0-323-05610-600017-2--s5360ampisbn=978-0-323-05610-6amptype=bookPageampsectionEid=4-u10-B978-0-323-05610-600017-2--s5360ampuniqId=235821444-144-u10-B978-0-323-05610-600017-2--s5360
2httpbibliotecafucsaludeduco2052dasarticlebody2358214449jorg=journalampsource=ampsp=15722101ampsid=0N4923641htmlissn=0002-838X
3 httpbibliotecafucsaludeduco2079ehostimageQuickViewsid=e4a56fd5-6fec-4ce9-acce3e707d09a138sessionmgr114ampvid=11ampui=6634823ampid=39764569ampparentui=39764569amptag=ANampdb=lth
4 httpbibliotecafucsaludeduco2052bookspagedoeid=4-u10-B978-0-323-05610-600017-2--s5360ampisbn=978-0-323-05610-6amptype=bookPageampsectionEid=4-u10-B978-0-323-05610-600017-2--s5360ampuniqId=235821444-144-u10-B978-0-323-05610-600017-2--s5360
5 httpbibliotecafucsaludeduco2052dasarticlebody235821444-14jorg=journalampsource=ampsp=15722101ampsid=0N4923641htmlissn=0002-838X
Bibliografia
Hyperthyroidism Diagnosis and Treatment
American Family Physician - Volume 72 Issue 4 (August 2005) - Copyright copy 2005 American Academy of Family Physicians
Hyperthyroidism in children and adolescents (English) By GODOY C CLAUDIA ACEVEDO M MARCELA BARRERA N ANTONIO YISMEYIAacuteN M ANAHIacute UGARTE P FRANCISCA Revista Chilena de Pediatriacutea enefeb2009 Vol 80 Issue 1 p21-29 9p 2 Charts 2 Graphs Language Spanish (AN 39764569)
httpdecsbvsbrcgi-binwxis1660exedecsserver
wwwmdconsultcom
wwwelseivercom
httpwwwgooglecomcoimagesum=1amphl=esampbiw=1024ampbih=573amptbs=isch3A1ampsa=1ampq=hipertiroidismoampbtnG=Buscarampaq=fampaqi=g4g-s2g4ampaql=ampoq=
httpwwwmedicina21comdocphpop=enfermedades3ampp=Hampef=Hipertiroidismoampid=1386
httpwwwgooglecomcoimagesum=1amphl=esampq=tratamiento20hipertiroidismoampie=UTF-8ampsource=ogampsa=Namptab=wiampbiw=1024ampbih=573
Tratamiento
BLOQUEADORES BETA
ofrecen alivio raacutepido de los siacutentomas adreneacutergicos de hipertiroidismo como temblor palpitaciones intolerancia al calor y el nerviosismo
YODUROS
bloquean la conversioacuten perifeacuterica de tiroxina (T4) en triyodotironina (T3) e inhiben la liberacioacuten de hormonas Yoduros tambieacuten se utilizan como terapia adyuvante antes de la cirugiacutea de emergencia no tiroideas
ANTITIROIDEOS
actuacutean principalmente al interferir con la organificacioacuten del yodo por lo tanto la supresioacuten de los niveles de hormona tiroidea
YODO RADIOACTIVO
es el tratamiento de eleccioacuten para la mayoriacutea de los pacientes con enfermedad de Graves y bocio nodular toacutexico
CIRUGIacuteA
Una tiroidectomiacutea subtotal se realiza con mayor frecuencia Esta cirugiacutea se conserva parte del tejido de la tiroides y reduce la incidencia de hipotiroidismo a 25 por ciento pero hipertiroidismo persistente o recurrente se produce en un 8 por ciento de los pacientesTiroidectomiacutea total se reserva para pacientes con enfermedad severa o grandes bocios en los que las recurrencias se muy problemaacutetico sino que lleva a un mayor riesgo de hiperparatiroidismo y el dantildeo del nervio lariacutengeo
NUEVAS POSIBILIDADES
Nuevas opciones de tratamiento bajo investigacioacuten incluyen la tiroidectomiacutea subtotal endoscoacutepica la embolizacioacuten de las arterias tiroides la plasmafeacuteresis y la inyeccioacuten percutaacutenea de etanol de toacutexicos noacutedulos de la tiroides (5)
httpwwwgooglecomcoimgresimgurl=httpwwwhealth32comwp-contentuploads201010Methimazole-10-mg-MUTjpgampimgrefurl=httpwwwhealth32comesmethimazoleampusg=__N2S0Cf6MoE4Ja9fPvg5bTiTr3U0=amph=225ampw=300ampsz=19amphl=esampstart=94ampzoom=1amptbnid=JnXgGiaRwrkjRMamptbnh=128amptbnw=179ampei=zphgTaiaPMGp8AalsKSxDAampprev
AbstractBackground Structural details of vertebrate extraocular muscles (EOMs) have shown an anatomically and functionally distinct laminar organization into an outer orbital (OL) and an inner global layer (GL) Since hyperthyroidism alters tissue oxidative metabolism through mitochondrial enzymes it is expected that structuralmitochondrial changes may be seen in hyperthyroid EOMs We investigated the alterations in the laminar organization and mitochondrial changes in hyperthyroid mouse EOMs Methods Hyperthyroidism was induced in C57BL6 mice and fresh rectus muscles were obtained to identify functional mitochondria using MitoTrackerreg Green and confocal microscopy frozen sections from rectus muscles were stained with anti-rabbit Troponin T (selectively present in the OL) to demonstrate changes in the OL and GL of the EOMs Ultrastructuralfeatures of EOMs were studied using transmission electron microscopy (TEM)
RESULTS Of all four rectus EOMs studied the maximum change was seen in the inferior rectus muscle (IR) followed by medial rectus (MR) Myofibercross-sectional area measurements and Troponin T staining in the control IR EOMs demonstrated a smaller OL (1132thinspplusmnthinsp366thinspμm(2)) and higher density staining with Troponin T (90) and a larger GL (411thinspplusmnthinsp1384thinspμm(2)) with low intensity staining (10) while hyperthyroidism resulted in an increased OL (2059thinspplusmnthinsp53thinspμm(2)) and decreased GL (2717 plusmn 75 μm(2)) pthinsp=thinsp0001 Confocal microscopy demonstrated an intense staining especially in the outer rims in the hyperthyroid IR which was confirmed by TEM showing structural alterations in the mitochondria and a subsarcolemmalmigration Conclusions The outer thinner OL of the mouse EOM contains smaller diameter myofibers and fewer mitochondria while the inner larger GL contains larger diameter myofibers and larger density of mitochondria Hyperthyroidism results in a significant alteration in the laminar organization and mitochondrial alterations of mouse EOMs
Effects of hyperthyroidism on the rectus muscles in mice
bullAutores
Nien CJ Jester JV Bose S
bullLink
httpwwwncbinlmnihgovpubmed21212842
Comentario Este articulo es interesante ya que nos habla de la introduccioacuten del
hipertiroidismo en ratones con muacutesculos rectos frescos para poder identificar las mitocondrias funcionales utilizando MitoTracker reg Green y microscopiacutea confocal los cortes congelados de los muacutesculos rectos se tintildeeron con T anti-conejo de troponina (selectivamente en la OC) para poder demostrar cambios en el OC y GL de las misiones de observacioacuten electoral De las cuatro misiones de observacioacuten electoral de los rectos estudiados mostraron el cambio maacuteximo el muacutesculo recto inferior (IR) seguido del recto medial (RM)
AbstractA 63-year-old female was admitted to our hospital with a tender abdominal wall mass about 15 cm in diameter which she had for 1 month About 1 week earlier the patient had also perceived a mass in the neck area Computed tomography revealed huge thyroid and periumbilical masses The thyroid hormone levels were consistent with a hyperthyroid state Pathological examination of the thyroid mass was compatible with anaplastic thyroid carcinoma (ATC) and the abdominal cutaneous mass was shown to be metastatic ATC Despite palliative radiotherapy and chemotherapy the patient died of respiratory failure on her 63rd day of hospitalization This case demonstrates that abdominal cutaneous metastasis and hyperthyroidism can occur as initial manifestations of ATC To our knowledge this is the first reported case
Anaplastic thyroid carcinoma initially presented with abdominal cutaneous mass and hyperthyroidism
bullAutoresLim KH Lee KW Kim JH Park SY Choi SH Lee JS
bullLinkhttpwwwncbinlmnihgovpubmed21179285
Comentario El articulo nos habla de el primer caso reportado por la metaacutestasis
cutaacutenea abdominal y el hipertiroidismo ocurrido por la manifestacioacuten inicial de la ATC en una mujer de 63 antildeos de edad que fue admitida en un hospital con una masa blanda de la pared abdominal de unos 15 cm de diaacutemetro que teniacutea por 1 mes Alrededor de 1 semana antes el paciente habiacutea percibido tambieacuten una misa en la zona del cuello La tomografiacutea computarizada reveloacute enormes masas de tiroides y periumbilical Los niveles de hormonas tiroideas eran compatibles con un estado de hipertiroidismo
1 httpbibliotecafucsaludeduco2052bookspagedoeid=4-u10-B978-0-323-05610-600017-2--s5360ampisbn=978-0-323-05610-6amptype=bookPageampsectionEid=4-u10-B978-0-323-05610-600017-2--s5360ampuniqId=235821444-144-u10-B978-0-323-05610-600017-2--s5360
2httpbibliotecafucsaludeduco2052dasarticlebody2358214449jorg=journalampsource=ampsp=15722101ampsid=0N4923641htmlissn=0002-838X
3 httpbibliotecafucsaludeduco2079ehostimageQuickViewsid=e4a56fd5-6fec-4ce9-acce3e707d09a138sessionmgr114ampvid=11ampui=6634823ampid=39764569ampparentui=39764569amptag=ANampdb=lth
4 httpbibliotecafucsaludeduco2052bookspagedoeid=4-u10-B978-0-323-05610-600017-2--s5360ampisbn=978-0-323-05610-6amptype=bookPageampsectionEid=4-u10-B978-0-323-05610-600017-2--s5360ampuniqId=235821444-144-u10-B978-0-323-05610-600017-2--s5360
5 httpbibliotecafucsaludeduco2052dasarticlebody235821444-14jorg=journalampsource=ampsp=15722101ampsid=0N4923641htmlissn=0002-838X
Bibliografia
Hyperthyroidism Diagnosis and Treatment
American Family Physician - Volume 72 Issue 4 (August 2005) - Copyright copy 2005 American Academy of Family Physicians
Hyperthyroidism in children and adolescents (English) By GODOY C CLAUDIA ACEVEDO M MARCELA BARRERA N ANTONIO YISMEYIAacuteN M ANAHIacute UGARTE P FRANCISCA Revista Chilena de Pediatriacutea enefeb2009 Vol 80 Issue 1 p21-29 9p 2 Charts 2 Graphs Language Spanish (AN 39764569)
httpdecsbvsbrcgi-binwxis1660exedecsserver
wwwmdconsultcom
wwwelseivercom
httpwwwmedicina21comdocphpop=enfermedades3ampp=Hampef=Hipertiroidismoampid=1386
httpwwwgooglecomcoimagesum=1amphl=esampq=tratamiento20hipertiroidismoampie=UTF-8ampsource=ogampsa=Namptab=wiampbiw=1024ampbih=573
Tratamiento
BLOQUEADORES BETA
ofrecen alivio raacutepido de los siacutentomas adreneacutergicos de hipertiroidismo como temblor palpitaciones intolerancia al calor y el nerviosismo
YODUROS
bloquean la conversioacuten perifeacuterica de tiroxina (T4) en triyodotironina (T3) e inhiben la liberacioacuten de hormonas Yoduros tambieacuten se utilizan como terapia adyuvante antes de la cirugiacutea de emergencia no tiroideas
ANTITIROIDEOS
actuacutean principalmente al interferir con la organificacioacuten del yodo por lo tanto la supresioacuten de los niveles de hormona tiroidea
YODO RADIOACTIVO
es el tratamiento de eleccioacuten para la mayoriacutea de los pacientes con enfermedad de Graves y bocio nodular toacutexico
CIRUGIacuteA
Una tiroidectomiacutea subtotal se realiza con mayor frecuencia Esta cirugiacutea se conserva parte del tejido de la tiroides y reduce la incidencia de hipotiroidismo a 25 por ciento pero hipertiroidismo persistente o recurrente se produce en un 8 por ciento de los pacientesTiroidectomiacutea total se reserva para pacientes con enfermedad severa o grandes bocios en los que las recurrencias se muy problemaacutetico sino que lleva a un mayor riesgo de hiperparatiroidismo y el dantildeo del nervio lariacutengeo
NUEVAS POSIBILIDADES
Nuevas opciones de tratamiento bajo investigacioacuten incluyen la tiroidectomiacutea subtotal endoscoacutepica la embolizacioacuten de las arterias tiroides la plasmafeacuteresis y la inyeccioacuten percutaacutenea de etanol de toacutexicos noacutedulos de la tiroides (5)
httpwwwgooglecomcoimgresimgurl=httpwwwhealth32comwp-contentuploads201010Methimazole-10-mg-MUTjpgampimgrefurl=httpwwwhealth32comesmethimazoleampusg=__N2S0Cf6MoE4Ja9fPvg5bTiTr3U0=amph=225ampw=300ampsz=19amphl=esampstart=94ampzoom=1amptbnid=JnXgGiaRwrkjRMamptbnh=128amptbnw=179ampei=zphgTaiaPMGp8AalsKSxDAampprev
AbstractBackground Structural details of vertebrate extraocular muscles (EOMs) have shown an anatomically and functionally distinct laminar organization into an outer orbital (OL) and an inner global layer (GL) Since hyperthyroidism alters tissue oxidative metabolism through mitochondrial enzymes it is expected that structuralmitochondrial changes may be seen in hyperthyroid EOMs We investigated the alterations in the laminar organization and mitochondrial changes in hyperthyroid mouse EOMs Methods Hyperthyroidism was induced in C57BL6 mice and fresh rectus muscles were obtained to identify functional mitochondria using MitoTrackerreg Green and confocal microscopy frozen sections from rectus muscles were stained with anti-rabbit Troponin T (selectively present in the OL) to demonstrate changes in the OL and GL of the EOMs Ultrastructuralfeatures of EOMs were studied using transmission electron microscopy (TEM)
RESULTS Of all four rectus EOMs studied the maximum change was seen in the inferior rectus muscle (IR) followed by medial rectus (MR) Myofibercross-sectional area measurements and Troponin T staining in the control IR EOMs demonstrated a smaller OL (1132thinspplusmnthinsp366thinspμm(2)) and higher density staining with Troponin T (90) and a larger GL (411thinspplusmnthinsp1384thinspμm(2)) with low intensity staining (10) while hyperthyroidism resulted in an increased OL (2059thinspplusmnthinsp53thinspμm(2)) and decreased GL (2717 plusmn 75 μm(2)) pthinsp=thinsp0001 Confocal microscopy demonstrated an intense staining especially in the outer rims in the hyperthyroid IR which was confirmed by TEM showing structural alterations in the mitochondria and a subsarcolemmalmigration Conclusions The outer thinner OL of the mouse EOM contains smaller diameter myofibers and fewer mitochondria while the inner larger GL contains larger diameter myofibers and larger density of mitochondria Hyperthyroidism results in a significant alteration in the laminar organization and mitochondrial alterations of mouse EOMs
Effects of hyperthyroidism on the rectus muscles in mice
bullAutores
Nien CJ Jester JV Bose S
bullLink
httpwwwncbinlmnihgovpubmed21212842
Comentario Este articulo es interesante ya que nos habla de la introduccioacuten del
hipertiroidismo en ratones con muacutesculos rectos frescos para poder identificar las mitocondrias funcionales utilizando MitoTracker reg Green y microscopiacutea confocal los cortes congelados de los muacutesculos rectos se tintildeeron con T anti-conejo de troponina (selectivamente en la OC) para poder demostrar cambios en el OC y GL de las misiones de observacioacuten electoral De las cuatro misiones de observacioacuten electoral de los rectos estudiados mostraron el cambio maacuteximo el muacutesculo recto inferior (IR) seguido del recto medial (RM)
AbstractA 63-year-old female was admitted to our hospital with a tender abdominal wall mass about 15 cm in diameter which she had for 1 month About 1 week earlier the patient had also perceived a mass in the neck area Computed tomography revealed huge thyroid and periumbilical masses The thyroid hormone levels were consistent with a hyperthyroid state Pathological examination of the thyroid mass was compatible with anaplastic thyroid carcinoma (ATC) and the abdominal cutaneous mass was shown to be metastatic ATC Despite palliative radiotherapy and chemotherapy the patient died of respiratory failure on her 63rd day of hospitalization This case demonstrates that abdominal cutaneous metastasis and hyperthyroidism can occur as initial manifestations of ATC To our knowledge this is the first reported case
Anaplastic thyroid carcinoma initially presented with abdominal cutaneous mass and hyperthyroidism
bullAutoresLim KH Lee KW Kim JH Park SY Choi SH Lee JS
bullLinkhttpwwwncbinlmnihgovpubmed21179285
Comentario El articulo nos habla de el primer caso reportado por la metaacutestasis
cutaacutenea abdominal y el hipertiroidismo ocurrido por la manifestacioacuten inicial de la ATC en una mujer de 63 antildeos de edad que fue admitida en un hospital con una masa blanda de la pared abdominal de unos 15 cm de diaacutemetro que teniacutea por 1 mes Alrededor de 1 semana antes el paciente habiacutea percibido tambieacuten una misa en la zona del cuello La tomografiacutea computarizada reveloacute enormes masas de tiroides y periumbilical Los niveles de hormonas tiroideas eran compatibles con un estado de hipertiroidismo
1 httpbibliotecafucsaludeduco2052bookspagedoeid=4-u10-B978-0-323-05610-600017-2--s5360ampisbn=978-0-323-05610-6amptype=bookPageampsectionEid=4-u10-B978-0-323-05610-600017-2--s5360ampuniqId=235821444-144-u10-B978-0-323-05610-600017-2--s5360
2httpbibliotecafucsaludeduco2052dasarticlebody2358214449jorg=journalampsource=ampsp=15722101ampsid=0N4923641htmlissn=0002-838X
3 httpbibliotecafucsaludeduco2079ehostimageQuickViewsid=e4a56fd5-6fec-4ce9-acce3e707d09a138sessionmgr114ampvid=11ampui=6634823ampid=39764569ampparentui=39764569amptag=ANampdb=lth
4 httpbibliotecafucsaludeduco2052bookspagedoeid=4-u10-B978-0-323-05610-600017-2--s5360ampisbn=978-0-323-05610-6amptype=bookPageampsectionEid=4-u10-B978-0-323-05610-600017-2--s5360ampuniqId=235821444-144-u10-B978-0-323-05610-600017-2--s5360
5 httpbibliotecafucsaludeduco2052dasarticlebody235821444-14jorg=journalampsource=ampsp=15722101ampsid=0N4923641htmlissn=0002-838X
Bibliografia
Hyperthyroidism Diagnosis and Treatment
American Family Physician - Volume 72 Issue 4 (August 2005) - Copyright copy 2005 American Academy of Family Physicians
Hyperthyroidism in children and adolescents (English) By GODOY C CLAUDIA ACEVEDO M MARCELA BARRERA N ANTONIO YISMEYIAacuteN M ANAHIacute UGARTE P FRANCISCA Revista Chilena de Pediatriacutea enefeb2009 Vol 80 Issue 1 p21-29 9p 2 Charts 2 Graphs Language Spanish (AN 39764569)
httpdecsbvsbrcgi-binwxis1660exedecsserver
wwwmdconsultcom
wwwelseivercom
httpwwwgooglecomcoimagesum=1amphl=esampq=tratamiento20hipertiroidismoampie=UTF-8ampsource=ogampsa=Namptab=wiampbiw=1024ampbih=573
Tratamiento
BLOQUEADORES BETA
ofrecen alivio raacutepido de los siacutentomas adreneacutergicos de hipertiroidismo como temblor palpitaciones intolerancia al calor y el nerviosismo
YODUROS
bloquean la conversioacuten perifeacuterica de tiroxina (T4) en triyodotironina (T3) e inhiben la liberacioacuten de hormonas Yoduros tambieacuten se utilizan como terapia adyuvante antes de la cirugiacutea de emergencia no tiroideas
ANTITIROIDEOS
actuacutean principalmente al interferir con la organificacioacuten del yodo por lo tanto la supresioacuten de los niveles de hormona tiroidea
YODO RADIOACTIVO
es el tratamiento de eleccioacuten para la mayoriacutea de los pacientes con enfermedad de Graves y bocio nodular toacutexico
CIRUGIacuteA
Una tiroidectomiacutea subtotal se realiza con mayor frecuencia Esta cirugiacutea se conserva parte del tejido de la tiroides y reduce la incidencia de hipotiroidismo a 25 por ciento pero hipertiroidismo persistente o recurrente se produce en un 8 por ciento de los pacientesTiroidectomiacutea total se reserva para pacientes con enfermedad severa o grandes bocios en los que las recurrencias se muy problemaacutetico sino que lleva a un mayor riesgo de hiperparatiroidismo y el dantildeo del nervio lariacutengeo
NUEVAS POSIBILIDADES
Nuevas opciones de tratamiento bajo investigacioacuten incluyen la tiroidectomiacutea subtotal endoscoacutepica la embolizacioacuten de las arterias tiroides la plasmafeacuteresis y la inyeccioacuten percutaacutenea de etanol de toacutexicos noacutedulos de la tiroides (5)
httpwwwgooglecomcoimgresimgurl=httpwwwhealth32comwp-contentuploads201010Methimazole-10-mg-MUTjpgampimgrefurl=httpwwwhealth32comesmethimazoleampusg=__N2S0Cf6MoE4Ja9fPvg5bTiTr3U0=amph=225ampw=300ampsz=19amphl=esampstart=94ampzoom=1amptbnid=JnXgGiaRwrkjRMamptbnh=128amptbnw=179ampei=zphgTaiaPMGp8AalsKSxDAampprev
AbstractBackground Structural details of vertebrate extraocular muscles (EOMs) have shown an anatomically and functionally distinct laminar organization into an outer orbital (OL) and an inner global layer (GL) Since hyperthyroidism alters tissue oxidative metabolism through mitochondrial enzymes it is expected that structuralmitochondrial changes may be seen in hyperthyroid EOMs We investigated the alterations in the laminar organization and mitochondrial changes in hyperthyroid mouse EOMs Methods Hyperthyroidism was induced in C57BL6 mice and fresh rectus muscles were obtained to identify functional mitochondria using MitoTrackerreg Green and confocal microscopy frozen sections from rectus muscles were stained with anti-rabbit Troponin T (selectively present in the OL) to demonstrate changes in the OL and GL of the EOMs Ultrastructuralfeatures of EOMs were studied using transmission electron microscopy (TEM)
RESULTS Of all four rectus EOMs studied the maximum change was seen in the inferior rectus muscle (IR) followed by medial rectus (MR) Myofibercross-sectional area measurements and Troponin T staining in the control IR EOMs demonstrated a smaller OL (1132thinspplusmnthinsp366thinspμm(2)) and higher density staining with Troponin T (90) and a larger GL (411thinspplusmnthinsp1384thinspμm(2)) with low intensity staining (10) while hyperthyroidism resulted in an increased OL (2059thinspplusmnthinsp53thinspμm(2)) and decreased GL (2717 plusmn 75 μm(2)) pthinsp=thinsp0001 Confocal microscopy demonstrated an intense staining especially in the outer rims in the hyperthyroid IR which was confirmed by TEM showing structural alterations in the mitochondria and a subsarcolemmalmigration Conclusions The outer thinner OL of the mouse EOM contains smaller diameter myofibers and fewer mitochondria while the inner larger GL contains larger diameter myofibers and larger density of mitochondria Hyperthyroidism results in a significant alteration in the laminar organization and mitochondrial alterations of mouse EOMs
Effects of hyperthyroidism on the rectus muscles in mice
bullAutores
Nien CJ Jester JV Bose S
bullLink
httpwwwncbinlmnihgovpubmed21212842
Comentario Este articulo es interesante ya que nos habla de la introduccioacuten del
hipertiroidismo en ratones con muacutesculos rectos frescos para poder identificar las mitocondrias funcionales utilizando MitoTracker reg Green y microscopiacutea confocal los cortes congelados de los muacutesculos rectos se tintildeeron con T anti-conejo de troponina (selectivamente en la OC) para poder demostrar cambios en el OC y GL de las misiones de observacioacuten electoral De las cuatro misiones de observacioacuten electoral de los rectos estudiados mostraron el cambio maacuteximo el muacutesculo recto inferior (IR) seguido del recto medial (RM)
AbstractA 63-year-old female was admitted to our hospital with a tender abdominal wall mass about 15 cm in diameter which she had for 1 month About 1 week earlier the patient had also perceived a mass in the neck area Computed tomography revealed huge thyroid and periumbilical masses The thyroid hormone levels were consistent with a hyperthyroid state Pathological examination of the thyroid mass was compatible with anaplastic thyroid carcinoma (ATC) and the abdominal cutaneous mass was shown to be metastatic ATC Despite palliative radiotherapy and chemotherapy the patient died of respiratory failure on her 63rd day of hospitalization This case demonstrates that abdominal cutaneous metastasis and hyperthyroidism can occur as initial manifestations of ATC To our knowledge this is the first reported case
Anaplastic thyroid carcinoma initially presented with abdominal cutaneous mass and hyperthyroidism
bullAutoresLim KH Lee KW Kim JH Park SY Choi SH Lee JS
bullLinkhttpwwwncbinlmnihgovpubmed21179285
Comentario El articulo nos habla de el primer caso reportado por la metaacutestasis
cutaacutenea abdominal y el hipertiroidismo ocurrido por la manifestacioacuten inicial de la ATC en una mujer de 63 antildeos de edad que fue admitida en un hospital con una masa blanda de la pared abdominal de unos 15 cm de diaacutemetro que teniacutea por 1 mes Alrededor de 1 semana antes el paciente habiacutea percibido tambieacuten una misa en la zona del cuello La tomografiacutea computarizada reveloacute enormes masas de tiroides y periumbilical Los niveles de hormonas tiroideas eran compatibles con un estado de hipertiroidismo
1 httpbibliotecafucsaludeduco2052bookspagedoeid=4-u10-B978-0-323-05610-600017-2--s5360ampisbn=978-0-323-05610-6amptype=bookPageampsectionEid=4-u10-B978-0-323-05610-600017-2--s5360ampuniqId=235821444-144-u10-B978-0-323-05610-600017-2--s5360
2httpbibliotecafucsaludeduco2052dasarticlebody2358214449jorg=journalampsource=ampsp=15722101ampsid=0N4923641htmlissn=0002-838X
3 httpbibliotecafucsaludeduco2079ehostimageQuickViewsid=e4a56fd5-6fec-4ce9-acce3e707d09a138sessionmgr114ampvid=11ampui=6634823ampid=39764569ampparentui=39764569amptag=ANampdb=lth
4 httpbibliotecafucsaludeduco2052bookspagedoeid=4-u10-B978-0-323-05610-600017-2--s5360ampisbn=978-0-323-05610-6amptype=bookPageampsectionEid=4-u10-B978-0-323-05610-600017-2--s5360ampuniqId=235821444-144-u10-B978-0-323-05610-600017-2--s5360
5 httpbibliotecafucsaludeduco2052dasarticlebody235821444-14jorg=journalampsource=ampsp=15722101ampsid=0N4923641htmlissn=0002-838X
Bibliografia
Hyperthyroidism Diagnosis and Treatment
American Family Physician - Volume 72 Issue 4 (August 2005) - Copyright copy 2005 American Academy of Family Physicians
Hyperthyroidism in children and adolescents (English) By GODOY C CLAUDIA ACEVEDO M MARCELA BARRERA N ANTONIO YISMEYIAacuteN M ANAHIacute UGARTE P FRANCISCA Revista Chilena de Pediatriacutea enefeb2009 Vol 80 Issue 1 p21-29 9p 2 Charts 2 Graphs Language Spanish (AN 39764569)
httpdecsbvsbrcgi-binwxis1660exedecsserver
wwwmdconsultcom
wwwelseivercom
Tratamiento
BLOQUEADORES BETA
ofrecen alivio raacutepido de los siacutentomas adreneacutergicos de hipertiroidismo como temblor palpitaciones intolerancia al calor y el nerviosismo
YODUROS
bloquean la conversioacuten perifeacuterica de tiroxina (T4) en triyodotironina (T3) e inhiben la liberacioacuten de hormonas Yoduros tambieacuten se utilizan como terapia adyuvante antes de la cirugiacutea de emergencia no tiroideas
ANTITIROIDEOS
actuacutean principalmente al interferir con la organificacioacuten del yodo por lo tanto la supresioacuten de los niveles de hormona tiroidea
YODO RADIOACTIVO
es el tratamiento de eleccioacuten para la mayoriacutea de los pacientes con enfermedad de Graves y bocio nodular toacutexico
CIRUGIacuteA
Una tiroidectomiacutea subtotal se realiza con mayor frecuencia Esta cirugiacutea se conserva parte del tejido de la tiroides y reduce la incidencia de hipotiroidismo a 25 por ciento pero hipertiroidismo persistente o recurrente se produce en un 8 por ciento de los pacientesTiroidectomiacutea total se reserva para pacientes con enfermedad severa o grandes bocios en los que las recurrencias se muy problemaacutetico sino que lleva a un mayor riesgo de hiperparatiroidismo y el dantildeo del nervio lariacutengeo
NUEVAS POSIBILIDADES
Nuevas opciones de tratamiento bajo investigacioacuten incluyen la tiroidectomiacutea subtotal endoscoacutepica la embolizacioacuten de las arterias tiroides la plasmafeacuteresis y la inyeccioacuten percutaacutenea de etanol de toacutexicos noacutedulos de la tiroides (5)
httpwwwgooglecomcoimgresimgurl=httpwwwhealth32comwp-contentuploads201010Methimazole-10-mg-MUTjpgampimgrefurl=httpwwwhealth32comesmethimazoleampusg=__N2S0Cf6MoE4Ja9fPvg5bTiTr3U0=amph=225ampw=300ampsz=19amphl=esampstart=94ampzoom=1amptbnid=JnXgGiaRwrkjRMamptbnh=128amptbnw=179ampei=zphgTaiaPMGp8AalsKSxDAampprev
AbstractBackground Structural details of vertebrate extraocular muscles (EOMs) have shown an anatomically and functionally distinct laminar organization into an outer orbital (OL) and an inner global layer (GL) Since hyperthyroidism alters tissue oxidative metabolism through mitochondrial enzymes it is expected that structuralmitochondrial changes may be seen in hyperthyroid EOMs We investigated the alterations in the laminar organization and mitochondrial changes in hyperthyroid mouse EOMs Methods Hyperthyroidism was induced in C57BL6 mice and fresh rectus muscles were obtained to identify functional mitochondria using MitoTrackerreg Green and confocal microscopy frozen sections from rectus muscles were stained with anti-rabbit Troponin T (selectively present in the OL) to demonstrate changes in the OL and GL of the EOMs Ultrastructuralfeatures of EOMs were studied using transmission electron microscopy (TEM)
RESULTS Of all four rectus EOMs studied the maximum change was seen in the inferior rectus muscle (IR) followed by medial rectus (MR) Myofibercross-sectional area measurements and Troponin T staining in the control IR EOMs demonstrated a smaller OL (1132thinspplusmnthinsp366thinspμm(2)) and higher density staining with Troponin T (90) and a larger GL (411thinspplusmnthinsp1384thinspμm(2)) with low intensity staining (10) while hyperthyroidism resulted in an increased OL (2059thinspplusmnthinsp53thinspμm(2)) and decreased GL (2717 plusmn 75 μm(2)) pthinsp=thinsp0001 Confocal microscopy demonstrated an intense staining especially in the outer rims in the hyperthyroid IR which was confirmed by TEM showing structural alterations in the mitochondria and a subsarcolemmalmigration Conclusions The outer thinner OL of the mouse EOM contains smaller diameter myofibers and fewer mitochondria while the inner larger GL contains larger diameter myofibers and larger density of mitochondria Hyperthyroidism results in a significant alteration in the laminar organization and mitochondrial alterations of mouse EOMs
Effects of hyperthyroidism on the rectus muscles in mice
bullAutores
Nien CJ Jester JV Bose S
bullLink
httpwwwncbinlmnihgovpubmed21212842
Comentario Este articulo es interesante ya que nos habla de la introduccioacuten del
hipertiroidismo en ratones con muacutesculos rectos frescos para poder identificar las mitocondrias funcionales utilizando MitoTracker reg Green y microscopiacutea confocal los cortes congelados de los muacutesculos rectos se tintildeeron con T anti-conejo de troponina (selectivamente en la OC) para poder demostrar cambios en el OC y GL de las misiones de observacioacuten electoral De las cuatro misiones de observacioacuten electoral de los rectos estudiados mostraron el cambio maacuteximo el muacutesculo recto inferior (IR) seguido del recto medial (RM)
AbstractA 63-year-old female was admitted to our hospital with a tender abdominal wall mass about 15 cm in diameter which she had for 1 month About 1 week earlier the patient had also perceived a mass in the neck area Computed tomography revealed huge thyroid and periumbilical masses The thyroid hormone levels were consistent with a hyperthyroid state Pathological examination of the thyroid mass was compatible with anaplastic thyroid carcinoma (ATC) and the abdominal cutaneous mass was shown to be metastatic ATC Despite palliative radiotherapy and chemotherapy the patient died of respiratory failure on her 63rd day of hospitalization This case demonstrates that abdominal cutaneous metastasis and hyperthyroidism can occur as initial manifestations of ATC To our knowledge this is the first reported case
Anaplastic thyroid carcinoma initially presented with abdominal cutaneous mass and hyperthyroidism
bullAutoresLim KH Lee KW Kim JH Park SY Choi SH Lee JS
bullLinkhttpwwwncbinlmnihgovpubmed21179285
Comentario El articulo nos habla de el primer caso reportado por la metaacutestasis
cutaacutenea abdominal y el hipertiroidismo ocurrido por la manifestacioacuten inicial de la ATC en una mujer de 63 antildeos de edad que fue admitida en un hospital con una masa blanda de la pared abdominal de unos 15 cm de diaacutemetro que teniacutea por 1 mes Alrededor de 1 semana antes el paciente habiacutea percibido tambieacuten una misa en la zona del cuello La tomografiacutea computarizada reveloacute enormes masas de tiroides y periumbilical Los niveles de hormonas tiroideas eran compatibles con un estado de hipertiroidismo
1 httpbibliotecafucsaludeduco2052bookspagedoeid=4-u10-B978-0-323-05610-600017-2--s5360ampisbn=978-0-323-05610-6amptype=bookPageampsectionEid=4-u10-B978-0-323-05610-600017-2--s5360ampuniqId=235821444-144-u10-B978-0-323-05610-600017-2--s5360
2httpbibliotecafucsaludeduco2052dasarticlebody2358214449jorg=journalampsource=ampsp=15722101ampsid=0N4923641htmlissn=0002-838X
3 httpbibliotecafucsaludeduco2079ehostimageQuickViewsid=e4a56fd5-6fec-4ce9-acce3e707d09a138sessionmgr114ampvid=11ampui=6634823ampid=39764569ampparentui=39764569amptag=ANampdb=lth
4 httpbibliotecafucsaludeduco2052bookspagedoeid=4-u10-B978-0-323-05610-600017-2--s5360ampisbn=978-0-323-05610-6amptype=bookPageampsectionEid=4-u10-B978-0-323-05610-600017-2--s5360ampuniqId=235821444-144-u10-B978-0-323-05610-600017-2--s5360
5 httpbibliotecafucsaludeduco2052dasarticlebody235821444-14jorg=journalampsource=ampsp=15722101ampsid=0N4923641htmlissn=0002-838X
Bibliografia
Hyperthyroidism Diagnosis and Treatment
American Family Physician - Volume 72 Issue 4 (August 2005) - Copyright copy 2005 American Academy of Family Physicians
Hyperthyroidism in children and adolescents (English) By GODOY C CLAUDIA ACEVEDO M MARCELA BARRERA N ANTONIO YISMEYIAacuteN M ANAHIacute UGARTE P FRANCISCA Revista Chilena de Pediatriacutea enefeb2009 Vol 80 Issue 1 p21-29 9p 2 Charts 2 Graphs Language Spanish (AN 39764569)
httpdecsbvsbrcgi-binwxis1660exedecsserver
wwwmdconsultcom
wwwelseivercom
CIRUGIacuteA
Una tiroidectomiacutea subtotal se realiza con mayor frecuencia Esta cirugiacutea se conserva parte del tejido de la tiroides y reduce la incidencia de hipotiroidismo a 25 por ciento pero hipertiroidismo persistente o recurrente se produce en un 8 por ciento de los pacientesTiroidectomiacutea total se reserva para pacientes con enfermedad severa o grandes bocios en los que las recurrencias se muy problemaacutetico sino que lleva a un mayor riesgo de hiperparatiroidismo y el dantildeo del nervio lariacutengeo
NUEVAS POSIBILIDADES
Nuevas opciones de tratamiento bajo investigacioacuten incluyen la tiroidectomiacutea subtotal endoscoacutepica la embolizacioacuten de las arterias tiroides la plasmafeacuteresis y la inyeccioacuten percutaacutenea de etanol de toacutexicos noacutedulos de la tiroides (5)
httpwwwgooglecomcoimgresimgurl=httpwwwhealth32comwp-contentuploads201010Methimazole-10-mg-MUTjpgampimgrefurl=httpwwwhealth32comesmethimazoleampusg=__N2S0Cf6MoE4Ja9fPvg5bTiTr3U0=amph=225ampw=300ampsz=19amphl=esampstart=94ampzoom=1amptbnid=JnXgGiaRwrkjRMamptbnh=128amptbnw=179ampei=zphgTaiaPMGp8AalsKSxDAampprev
AbstractBackground Structural details of vertebrate extraocular muscles (EOMs) have shown an anatomically and functionally distinct laminar organization into an outer orbital (OL) and an inner global layer (GL) Since hyperthyroidism alters tissue oxidative metabolism through mitochondrial enzymes it is expected that structuralmitochondrial changes may be seen in hyperthyroid EOMs We investigated the alterations in the laminar organization and mitochondrial changes in hyperthyroid mouse EOMs Methods Hyperthyroidism was induced in C57BL6 mice and fresh rectus muscles were obtained to identify functional mitochondria using MitoTrackerreg Green and confocal microscopy frozen sections from rectus muscles were stained with anti-rabbit Troponin T (selectively present in the OL) to demonstrate changes in the OL and GL of the EOMs Ultrastructuralfeatures of EOMs were studied using transmission electron microscopy (TEM)
RESULTS Of all four rectus EOMs studied the maximum change was seen in the inferior rectus muscle (IR) followed by medial rectus (MR) Myofibercross-sectional area measurements and Troponin T staining in the control IR EOMs demonstrated a smaller OL (1132thinspplusmnthinsp366thinspμm(2)) and higher density staining with Troponin T (90) and a larger GL (411thinspplusmnthinsp1384thinspμm(2)) with low intensity staining (10) while hyperthyroidism resulted in an increased OL (2059thinspplusmnthinsp53thinspμm(2)) and decreased GL (2717 plusmn 75 μm(2)) pthinsp=thinsp0001 Confocal microscopy demonstrated an intense staining especially in the outer rims in the hyperthyroid IR which was confirmed by TEM showing structural alterations in the mitochondria and a subsarcolemmalmigration Conclusions The outer thinner OL of the mouse EOM contains smaller diameter myofibers and fewer mitochondria while the inner larger GL contains larger diameter myofibers and larger density of mitochondria Hyperthyroidism results in a significant alteration in the laminar organization and mitochondrial alterations of mouse EOMs
Effects of hyperthyroidism on the rectus muscles in mice
bullAutores
Nien CJ Jester JV Bose S
bullLink
httpwwwncbinlmnihgovpubmed21212842
Comentario Este articulo es interesante ya que nos habla de la introduccioacuten del
hipertiroidismo en ratones con muacutesculos rectos frescos para poder identificar las mitocondrias funcionales utilizando MitoTracker reg Green y microscopiacutea confocal los cortes congelados de los muacutesculos rectos se tintildeeron con T anti-conejo de troponina (selectivamente en la OC) para poder demostrar cambios en el OC y GL de las misiones de observacioacuten electoral De las cuatro misiones de observacioacuten electoral de los rectos estudiados mostraron el cambio maacuteximo el muacutesculo recto inferior (IR) seguido del recto medial (RM)
AbstractA 63-year-old female was admitted to our hospital with a tender abdominal wall mass about 15 cm in diameter which she had for 1 month About 1 week earlier the patient had also perceived a mass in the neck area Computed tomography revealed huge thyroid and periumbilical masses The thyroid hormone levels were consistent with a hyperthyroid state Pathological examination of the thyroid mass was compatible with anaplastic thyroid carcinoma (ATC) and the abdominal cutaneous mass was shown to be metastatic ATC Despite palliative radiotherapy and chemotherapy the patient died of respiratory failure on her 63rd day of hospitalization This case demonstrates that abdominal cutaneous metastasis and hyperthyroidism can occur as initial manifestations of ATC To our knowledge this is the first reported case
Anaplastic thyroid carcinoma initially presented with abdominal cutaneous mass and hyperthyroidism
bullAutoresLim KH Lee KW Kim JH Park SY Choi SH Lee JS
bullLinkhttpwwwncbinlmnihgovpubmed21179285
Comentario El articulo nos habla de el primer caso reportado por la metaacutestasis
cutaacutenea abdominal y el hipertiroidismo ocurrido por la manifestacioacuten inicial de la ATC en una mujer de 63 antildeos de edad que fue admitida en un hospital con una masa blanda de la pared abdominal de unos 15 cm de diaacutemetro que teniacutea por 1 mes Alrededor de 1 semana antes el paciente habiacutea percibido tambieacuten una misa en la zona del cuello La tomografiacutea computarizada reveloacute enormes masas de tiroides y periumbilical Los niveles de hormonas tiroideas eran compatibles con un estado de hipertiroidismo
1 httpbibliotecafucsaludeduco2052bookspagedoeid=4-u10-B978-0-323-05610-600017-2--s5360ampisbn=978-0-323-05610-6amptype=bookPageampsectionEid=4-u10-B978-0-323-05610-600017-2--s5360ampuniqId=235821444-144-u10-B978-0-323-05610-600017-2--s5360
2httpbibliotecafucsaludeduco2052dasarticlebody2358214449jorg=journalampsource=ampsp=15722101ampsid=0N4923641htmlissn=0002-838X
3 httpbibliotecafucsaludeduco2079ehostimageQuickViewsid=e4a56fd5-6fec-4ce9-acce3e707d09a138sessionmgr114ampvid=11ampui=6634823ampid=39764569ampparentui=39764569amptag=ANampdb=lth
4 httpbibliotecafucsaludeduco2052bookspagedoeid=4-u10-B978-0-323-05610-600017-2--s5360ampisbn=978-0-323-05610-6amptype=bookPageampsectionEid=4-u10-B978-0-323-05610-600017-2--s5360ampuniqId=235821444-144-u10-B978-0-323-05610-600017-2--s5360
5 httpbibliotecafucsaludeduco2052dasarticlebody235821444-14jorg=journalampsource=ampsp=15722101ampsid=0N4923641htmlissn=0002-838X
Bibliografia
Hyperthyroidism Diagnosis and Treatment
American Family Physician - Volume 72 Issue 4 (August 2005) - Copyright copy 2005 American Academy of Family Physicians
Hyperthyroidism in children and adolescents (English) By GODOY C CLAUDIA ACEVEDO M MARCELA BARRERA N ANTONIO YISMEYIAacuteN M ANAHIacute UGARTE P FRANCISCA Revista Chilena de Pediatriacutea enefeb2009 Vol 80 Issue 1 p21-29 9p 2 Charts 2 Graphs Language Spanish (AN 39764569)
httpdecsbvsbrcgi-binwxis1660exedecsserver
wwwmdconsultcom
wwwelseivercom
httpwwwgooglecomcoimgresimgurl=httpwwwhealth32comwp-contentuploads201010Methimazole-10-mg-MUTjpgampimgrefurl=httpwwwhealth32comesmethimazoleampusg=__N2S0Cf6MoE4Ja9fPvg5bTiTr3U0=amph=225ampw=300ampsz=19amphl=esampstart=94ampzoom=1amptbnid=JnXgGiaRwrkjRMamptbnh=128amptbnw=179ampei=zphgTaiaPMGp8AalsKSxDAampprev
AbstractBackground Structural details of vertebrate extraocular muscles (EOMs) have shown an anatomically and functionally distinct laminar organization into an outer orbital (OL) and an inner global layer (GL) Since hyperthyroidism alters tissue oxidative metabolism through mitochondrial enzymes it is expected that structuralmitochondrial changes may be seen in hyperthyroid EOMs We investigated the alterations in the laminar organization and mitochondrial changes in hyperthyroid mouse EOMs Methods Hyperthyroidism was induced in C57BL6 mice and fresh rectus muscles were obtained to identify functional mitochondria using MitoTrackerreg Green and confocal microscopy frozen sections from rectus muscles were stained with anti-rabbit Troponin T (selectively present in the OL) to demonstrate changes in the OL and GL of the EOMs Ultrastructuralfeatures of EOMs were studied using transmission electron microscopy (TEM)
RESULTS Of all four rectus EOMs studied the maximum change was seen in the inferior rectus muscle (IR) followed by medial rectus (MR) Myofibercross-sectional area measurements and Troponin T staining in the control IR EOMs demonstrated a smaller OL (1132thinspplusmnthinsp366thinspμm(2)) and higher density staining with Troponin T (90) and a larger GL (411thinspplusmnthinsp1384thinspμm(2)) with low intensity staining (10) while hyperthyroidism resulted in an increased OL (2059thinspplusmnthinsp53thinspμm(2)) and decreased GL (2717 plusmn 75 μm(2)) pthinsp=thinsp0001 Confocal microscopy demonstrated an intense staining especially in the outer rims in the hyperthyroid IR which was confirmed by TEM showing structural alterations in the mitochondria and a subsarcolemmalmigration Conclusions The outer thinner OL of the mouse EOM contains smaller diameter myofibers and fewer mitochondria while the inner larger GL contains larger diameter myofibers and larger density of mitochondria Hyperthyroidism results in a significant alteration in the laminar organization and mitochondrial alterations of mouse EOMs
Effects of hyperthyroidism on the rectus muscles in mice
bullAutores
Nien CJ Jester JV Bose S
bullLink
httpwwwncbinlmnihgovpubmed21212842
Comentario Este articulo es interesante ya que nos habla de la introduccioacuten del
hipertiroidismo en ratones con muacutesculos rectos frescos para poder identificar las mitocondrias funcionales utilizando MitoTracker reg Green y microscopiacutea confocal los cortes congelados de los muacutesculos rectos se tintildeeron con T anti-conejo de troponina (selectivamente en la OC) para poder demostrar cambios en el OC y GL de las misiones de observacioacuten electoral De las cuatro misiones de observacioacuten electoral de los rectos estudiados mostraron el cambio maacuteximo el muacutesculo recto inferior (IR) seguido del recto medial (RM)
AbstractA 63-year-old female was admitted to our hospital with a tender abdominal wall mass about 15 cm in diameter which she had for 1 month About 1 week earlier the patient had also perceived a mass in the neck area Computed tomography revealed huge thyroid and periumbilical masses The thyroid hormone levels were consistent with a hyperthyroid state Pathological examination of the thyroid mass was compatible with anaplastic thyroid carcinoma (ATC) and the abdominal cutaneous mass was shown to be metastatic ATC Despite palliative radiotherapy and chemotherapy the patient died of respiratory failure on her 63rd day of hospitalization This case demonstrates that abdominal cutaneous metastasis and hyperthyroidism can occur as initial manifestations of ATC To our knowledge this is the first reported case
Anaplastic thyroid carcinoma initially presented with abdominal cutaneous mass and hyperthyroidism
bullAutoresLim KH Lee KW Kim JH Park SY Choi SH Lee JS
bullLinkhttpwwwncbinlmnihgovpubmed21179285
Comentario El articulo nos habla de el primer caso reportado por la metaacutestasis
cutaacutenea abdominal y el hipertiroidismo ocurrido por la manifestacioacuten inicial de la ATC en una mujer de 63 antildeos de edad que fue admitida en un hospital con una masa blanda de la pared abdominal de unos 15 cm de diaacutemetro que teniacutea por 1 mes Alrededor de 1 semana antes el paciente habiacutea percibido tambieacuten una misa en la zona del cuello La tomografiacutea computarizada reveloacute enormes masas de tiroides y periumbilical Los niveles de hormonas tiroideas eran compatibles con un estado de hipertiroidismo
1 httpbibliotecafucsaludeduco2052bookspagedoeid=4-u10-B978-0-323-05610-600017-2--s5360ampisbn=978-0-323-05610-6amptype=bookPageampsectionEid=4-u10-B978-0-323-05610-600017-2--s5360ampuniqId=235821444-144-u10-B978-0-323-05610-600017-2--s5360
2httpbibliotecafucsaludeduco2052dasarticlebody2358214449jorg=journalampsource=ampsp=15722101ampsid=0N4923641htmlissn=0002-838X
3 httpbibliotecafucsaludeduco2079ehostimageQuickViewsid=e4a56fd5-6fec-4ce9-acce3e707d09a138sessionmgr114ampvid=11ampui=6634823ampid=39764569ampparentui=39764569amptag=ANampdb=lth
4 httpbibliotecafucsaludeduco2052bookspagedoeid=4-u10-B978-0-323-05610-600017-2--s5360ampisbn=978-0-323-05610-6amptype=bookPageampsectionEid=4-u10-B978-0-323-05610-600017-2--s5360ampuniqId=235821444-144-u10-B978-0-323-05610-600017-2--s5360
5 httpbibliotecafucsaludeduco2052dasarticlebody235821444-14jorg=journalampsource=ampsp=15722101ampsid=0N4923641htmlissn=0002-838X
Bibliografia
Hyperthyroidism Diagnosis and Treatment
American Family Physician - Volume 72 Issue 4 (August 2005) - Copyright copy 2005 American Academy of Family Physicians
Hyperthyroidism in children and adolescents (English) By GODOY C CLAUDIA ACEVEDO M MARCELA BARRERA N ANTONIO YISMEYIAacuteN M ANAHIacute UGARTE P FRANCISCA Revista Chilena de Pediatriacutea enefeb2009 Vol 80 Issue 1 p21-29 9p 2 Charts 2 Graphs Language Spanish (AN 39764569)
httpdecsbvsbrcgi-binwxis1660exedecsserver
wwwmdconsultcom
wwwelseivercom
AbstractBackground Structural details of vertebrate extraocular muscles (EOMs) have shown an anatomically and functionally distinct laminar organization into an outer orbital (OL) and an inner global layer (GL) Since hyperthyroidism alters tissue oxidative metabolism through mitochondrial enzymes it is expected that structuralmitochondrial changes may be seen in hyperthyroid EOMs We investigated the alterations in the laminar organization and mitochondrial changes in hyperthyroid mouse EOMs Methods Hyperthyroidism was induced in C57BL6 mice and fresh rectus muscles were obtained to identify functional mitochondria using MitoTrackerreg Green and confocal microscopy frozen sections from rectus muscles were stained with anti-rabbit Troponin T (selectively present in the OL) to demonstrate changes in the OL and GL of the EOMs Ultrastructuralfeatures of EOMs were studied using transmission electron microscopy (TEM)
RESULTS Of all four rectus EOMs studied the maximum change was seen in the inferior rectus muscle (IR) followed by medial rectus (MR) Myofibercross-sectional area measurements and Troponin T staining in the control IR EOMs demonstrated a smaller OL (1132thinspplusmnthinsp366thinspμm(2)) and higher density staining with Troponin T (90) and a larger GL (411thinspplusmnthinsp1384thinspμm(2)) with low intensity staining (10) while hyperthyroidism resulted in an increased OL (2059thinspplusmnthinsp53thinspμm(2)) and decreased GL (2717 plusmn 75 μm(2)) pthinsp=thinsp0001 Confocal microscopy demonstrated an intense staining especially in the outer rims in the hyperthyroid IR which was confirmed by TEM showing structural alterations in the mitochondria and a subsarcolemmalmigration Conclusions The outer thinner OL of the mouse EOM contains smaller diameter myofibers and fewer mitochondria while the inner larger GL contains larger diameter myofibers and larger density of mitochondria Hyperthyroidism results in a significant alteration in the laminar organization and mitochondrial alterations of mouse EOMs
Effects of hyperthyroidism on the rectus muscles in mice
bullAutores
Nien CJ Jester JV Bose S
bullLink
httpwwwncbinlmnihgovpubmed21212842
Comentario Este articulo es interesante ya que nos habla de la introduccioacuten del
hipertiroidismo en ratones con muacutesculos rectos frescos para poder identificar las mitocondrias funcionales utilizando MitoTracker reg Green y microscopiacutea confocal los cortes congelados de los muacutesculos rectos se tintildeeron con T anti-conejo de troponina (selectivamente en la OC) para poder demostrar cambios en el OC y GL de las misiones de observacioacuten electoral De las cuatro misiones de observacioacuten electoral de los rectos estudiados mostraron el cambio maacuteximo el muacutesculo recto inferior (IR) seguido del recto medial (RM)
AbstractA 63-year-old female was admitted to our hospital with a tender abdominal wall mass about 15 cm in diameter which she had for 1 month About 1 week earlier the patient had also perceived a mass in the neck area Computed tomography revealed huge thyroid and periumbilical masses The thyroid hormone levels were consistent with a hyperthyroid state Pathological examination of the thyroid mass was compatible with anaplastic thyroid carcinoma (ATC) and the abdominal cutaneous mass was shown to be metastatic ATC Despite palliative radiotherapy and chemotherapy the patient died of respiratory failure on her 63rd day of hospitalization This case demonstrates that abdominal cutaneous metastasis and hyperthyroidism can occur as initial manifestations of ATC To our knowledge this is the first reported case
Anaplastic thyroid carcinoma initially presented with abdominal cutaneous mass and hyperthyroidism
bullAutoresLim KH Lee KW Kim JH Park SY Choi SH Lee JS
bullLinkhttpwwwncbinlmnihgovpubmed21179285
Comentario El articulo nos habla de el primer caso reportado por la metaacutestasis
cutaacutenea abdominal y el hipertiroidismo ocurrido por la manifestacioacuten inicial de la ATC en una mujer de 63 antildeos de edad que fue admitida en un hospital con una masa blanda de la pared abdominal de unos 15 cm de diaacutemetro que teniacutea por 1 mes Alrededor de 1 semana antes el paciente habiacutea percibido tambieacuten una misa en la zona del cuello La tomografiacutea computarizada reveloacute enormes masas de tiroides y periumbilical Los niveles de hormonas tiroideas eran compatibles con un estado de hipertiroidismo
1 httpbibliotecafucsaludeduco2052bookspagedoeid=4-u10-B978-0-323-05610-600017-2--s5360ampisbn=978-0-323-05610-6amptype=bookPageampsectionEid=4-u10-B978-0-323-05610-600017-2--s5360ampuniqId=235821444-144-u10-B978-0-323-05610-600017-2--s5360
2httpbibliotecafucsaludeduco2052dasarticlebody2358214449jorg=journalampsource=ampsp=15722101ampsid=0N4923641htmlissn=0002-838X
3 httpbibliotecafucsaludeduco2079ehostimageQuickViewsid=e4a56fd5-6fec-4ce9-acce3e707d09a138sessionmgr114ampvid=11ampui=6634823ampid=39764569ampparentui=39764569amptag=ANampdb=lth
4 httpbibliotecafucsaludeduco2052bookspagedoeid=4-u10-B978-0-323-05610-600017-2--s5360ampisbn=978-0-323-05610-6amptype=bookPageampsectionEid=4-u10-B978-0-323-05610-600017-2--s5360ampuniqId=235821444-144-u10-B978-0-323-05610-600017-2--s5360
5 httpbibliotecafucsaludeduco2052dasarticlebody235821444-14jorg=journalampsource=ampsp=15722101ampsid=0N4923641htmlissn=0002-838X
Bibliografia
Hyperthyroidism Diagnosis and Treatment
American Family Physician - Volume 72 Issue 4 (August 2005) - Copyright copy 2005 American Academy of Family Physicians
Hyperthyroidism in children and adolescents (English) By GODOY C CLAUDIA ACEVEDO M MARCELA BARRERA N ANTONIO YISMEYIAacuteN M ANAHIacute UGARTE P FRANCISCA Revista Chilena de Pediatriacutea enefeb2009 Vol 80 Issue 1 p21-29 9p 2 Charts 2 Graphs Language Spanish (AN 39764569)
httpdecsbvsbrcgi-binwxis1660exedecsserver
wwwmdconsultcom
wwwelseivercom
RESULTS Of all four rectus EOMs studied the maximum change was seen in the inferior rectus muscle (IR) followed by medial rectus (MR) Myofibercross-sectional area measurements and Troponin T staining in the control IR EOMs demonstrated a smaller OL (1132thinspplusmnthinsp366thinspμm(2)) and higher density staining with Troponin T (90) and a larger GL (411thinspplusmnthinsp1384thinspμm(2)) with low intensity staining (10) while hyperthyroidism resulted in an increased OL (2059thinspplusmnthinsp53thinspμm(2)) and decreased GL (2717 plusmn 75 μm(2)) pthinsp=thinsp0001 Confocal microscopy demonstrated an intense staining especially in the outer rims in the hyperthyroid IR which was confirmed by TEM showing structural alterations in the mitochondria and a subsarcolemmalmigration Conclusions The outer thinner OL of the mouse EOM contains smaller diameter myofibers and fewer mitochondria while the inner larger GL contains larger diameter myofibers and larger density of mitochondria Hyperthyroidism results in a significant alteration in the laminar organization and mitochondrial alterations of mouse EOMs
Effects of hyperthyroidism on the rectus muscles in mice
bullAutores
Nien CJ Jester JV Bose S
bullLink
httpwwwncbinlmnihgovpubmed21212842
Comentario Este articulo es interesante ya que nos habla de la introduccioacuten del
hipertiroidismo en ratones con muacutesculos rectos frescos para poder identificar las mitocondrias funcionales utilizando MitoTracker reg Green y microscopiacutea confocal los cortes congelados de los muacutesculos rectos se tintildeeron con T anti-conejo de troponina (selectivamente en la OC) para poder demostrar cambios en el OC y GL de las misiones de observacioacuten electoral De las cuatro misiones de observacioacuten electoral de los rectos estudiados mostraron el cambio maacuteximo el muacutesculo recto inferior (IR) seguido del recto medial (RM)
AbstractA 63-year-old female was admitted to our hospital with a tender abdominal wall mass about 15 cm in diameter which she had for 1 month About 1 week earlier the patient had also perceived a mass in the neck area Computed tomography revealed huge thyroid and periumbilical masses The thyroid hormone levels were consistent with a hyperthyroid state Pathological examination of the thyroid mass was compatible with anaplastic thyroid carcinoma (ATC) and the abdominal cutaneous mass was shown to be metastatic ATC Despite palliative radiotherapy and chemotherapy the patient died of respiratory failure on her 63rd day of hospitalization This case demonstrates that abdominal cutaneous metastasis and hyperthyroidism can occur as initial manifestations of ATC To our knowledge this is the first reported case
Anaplastic thyroid carcinoma initially presented with abdominal cutaneous mass and hyperthyroidism
bullAutoresLim KH Lee KW Kim JH Park SY Choi SH Lee JS
bullLinkhttpwwwncbinlmnihgovpubmed21179285
Comentario El articulo nos habla de el primer caso reportado por la metaacutestasis
cutaacutenea abdominal y el hipertiroidismo ocurrido por la manifestacioacuten inicial de la ATC en una mujer de 63 antildeos de edad que fue admitida en un hospital con una masa blanda de la pared abdominal de unos 15 cm de diaacutemetro que teniacutea por 1 mes Alrededor de 1 semana antes el paciente habiacutea percibido tambieacuten una misa en la zona del cuello La tomografiacutea computarizada reveloacute enormes masas de tiroides y periumbilical Los niveles de hormonas tiroideas eran compatibles con un estado de hipertiroidismo
1 httpbibliotecafucsaludeduco2052bookspagedoeid=4-u10-B978-0-323-05610-600017-2--s5360ampisbn=978-0-323-05610-6amptype=bookPageampsectionEid=4-u10-B978-0-323-05610-600017-2--s5360ampuniqId=235821444-144-u10-B978-0-323-05610-600017-2--s5360
2httpbibliotecafucsaludeduco2052dasarticlebody2358214449jorg=journalampsource=ampsp=15722101ampsid=0N4923641htmlissn=0002-838X
3 httpbibliotecafucsaludeduco2079ehostimageQuickViewsid=e4a56fd5-6fec-4ce9-acce3e707d09a138sessionmgr114ampvid=11ampui=6634823ampid=39764569ampparentui=39764569amptag=ANampdb=lth
4 httpbibliotecafucsaludeduco2052bookspagedoeid=4-u10-B978-0-323-05610-600017-2--s5360ampisbn=978-0-323-05610-6amptype=bookPageampsectionEid=4-u10-B978-0-323-05610-600017-2--s5360ampuniqId=235821444-144-u10-B978-0-323-05610-600017-2--s5360
5 httpbibliotecafucsaludeduco2052dasarticlebody235821444-14jorg=journalampsource=ampsp=15722101ampsid=0N4923641htmlissn=0002-838X
Bibliografia
Hyperthyroidism Diagnosis and Treatment
American Family Physician - Volume 72 Issue 4 (August 2005) - Copyright copy 2005 American Academy of Family Physicians
Hyperthyroidism in children and adolescents (English) By GODOY C CLAUDIA ACEVEDO M MARCELA BARRERA N ANTONIO YISMEYIAacuteN M ANAHIacute UGARTE P FRANCISCA Revista Chilena de Pediatriacutea enefeb2009 Vol 80 Issue 1 p21-29 9p 2 Charts 2 Graphs Language Spanish (AN 39764569)
httpdecsbvsbrcgi-binwxis1660exedecsserver
wwwmdconsultcom
wwwelseivercom
Effects of hyperthyroidism on the rectus muscles in mice
bullAutores
Nien CJ Jester JV Bose S
bullLink
httpwwwncbinlmnihgovpubmed21212842
Comentario Este articulo es interesante ya que nos habla de la introduccioacuten del
hipertiroidismo en ratones con muacutesculos rectos frescos para poder identificar las mitocondrias funcionales utilizando MitoTracker reg Green y microscopiacutea confocal los cortes congelados de los muacutesculos rectos se tintildeeron con T anti-conejo de troponina (selectivamente en la OC) para poder demostrar cambios en el OC y GL de las misiones de observacioacuten electoral De las cuatro misiones de observacioacuten electoral de los rectos estudiados mostraron el cambio maacuteximo el muacutesculo recto inferior (IR) seguido del recto medial (RM)
AbstractA 63-year-old female was admitted to our hospital with a tender abdominal wall mass about 15 cm in diameter which she had for 1 month About 1 week earlier the patient had also perceived a mass in the neck area Computed tomography revealed huge thyroid and periumbilical masses The thyroid hormone levels were consistent with a hyperthyroid state Pathological examination of the thyroid mass was compatible with anaplastic thyroid carcinoma (ATC) and the abdominal cutaneous mass was shown to be metastatic ATC Despite palliative radiotherapy and chemotherapy the patient died of respiratory failure on her 63rd day of hospitalization This case demonstrates that abdominal cutaneous metastasis and hyperthyroidism can occur as initial manifestations of ATC To our knowledge this is the first reported case
Anaplastic thyroid carcinoma initially presented with abdominal cutaneous mass and hyperthyroidism
bullAutoresLim KH Lee KW Kim JH Park SY Choi SH Lee JS
bullLinkhttpwwwncbinlmnihgovpubmed21179285
Comentario El articulo nos habla de el primer caso reportado por la metaacutestasis
cutaacutenea abdominal y el hipertiroidismo ocurrido por la manifestacioacuten inicial de la ATC en una mujer de 63 antildeos de edad que fue admitida en un hospital con una masa blanda de la pared abdominal de unos 15 cm de diaacutemetro que teniacutea por 1 mes Alrededor de 1 semana antes el paciente habiacutea percibido tambieacuten una misa en la zona del cuello La tomografiacutea computarizada reveloacute enormes masas de tiroides y periumbilical Los niveles de hormonas tiroideas eran compatibles con un estado de hipertiroidismo
1 httpbibliotecafucsaludeduco2052bookspagedoeid=4-u10-B978-0-323-05610-600017-2--s5360ampisbn=978-0-323-05610-6amptype=bookPageampsectionEid=4-u10-B978-0-323-05610-600017-2--s5360ampuniqId=235821444-144-u10-B978-0-323-05610-600017-2--s5360
2httpbibliotecafucsaludeduco2052dasarticlebody2358214449jorg=journalampsource=ampsp=15722101ampsid=0N4923641htmlissn=0002-838X
3 httpbibliotecafucsaludeduco2079ehostimageQuickViewsid=e4a56fd5-6fec-4ce9-acce3e707d09a138sessionmgr114ampvid=11ampui=6634823ampid=39764569ampparentui=39764569amptag=ANampdb=lth
4 httpbibliotecafucsaludeduco2052bookspagedoeid=4-u10-B978-0-323-05610-600017-2--s5360ampisbn=978-0-323-05610-6amptype=bookPageampsectionEid=4-u10-B978-0-323-05610-600017-2--s5360ampuniqId=235821444-144-u10-B978-0-323-05610-600017-2--s5360
5 httpbibliotecafucsaludeduco2052dasarticlebody235821444-14jorg=journalampsource=ampsp=15722101ampsid=0N4923641htmlissn=0002-838X
Bibliografia
Hyperthyroidism Diagnosis and Treatment
American Family Physician - Volume 72 Issue 4 (August 2005) - Copyright copy 2005 American Academy of Family Physicians
Hyperthyroidism in children and adolescents (English) By GODOY C CLAUDIA ACEVEDO M MARCELA BARRERA N ANTONIO YISMEYIAacuteN M ANAHIacute UGARTE P FRANCISCA Revista Chilena de Pediatriacutea enefeb2009 Vol 80 Issue 1 p21-29 9p 2 Charts 2 Graphs Language Spanish (AN 39764569)
httpdecsbvsbrcgi-binwxis1660exedecsserver
wwwmdconsultcom
wwwelseivercom
Comentario Este articulo es interesante ya que nos habla de la introduccioacuten del
hipertiroidismo en ratones con muacutesculos rectos frescos para poder identificar las mitocondrias funcionales utilizando MitoTracker reg Green y microscopiacutea confocal los cortes congelados de los muacutesculos rectos se tintildeeron con T anti-conejo de troponina (selectivamente en la OC) para poder demostrar cambios en el OC y GL de las misiones de observacioacuten electoral De las cuatro misiones de observacioacuten electoral de los rectos estudiados mostraron el cambio maacuteximo el muacutesculo recto inferior (IR) seguido del recto medial (RM)
AbstractA 63-year-old female was admitted to our hospital with a tender abdominal wall mass about 15 cm in diameter which she had for 1 month About 1 week earlier the patient had also perceived a mass in the neck area Computed tomography revealed huge thyroid and periumbilical masses The thyroid hormone levels were consistent with a hyperthyroid state Pathological examination of the thyroid mass was compatible with anaplastic thyroid carcinoma (ATC) and the abdominal cutaneous mass was shown to be metastatic ATC Despite palliative radiotherapy and chemotherapy the patient died of respiratory failure on her 63rd day of hospitalization This case demonstrates that abdominal cutaneous metastasis and hyperthyroidism can occur as initial manifestations of ATC To our knowledge this is the first reported case
Anaplastic thyroid carcinoma initially presented with abdominal cutaneous mass and hyperthyroidism
bullAutoresLim KH Lee KW Kim JH Park SY Choi SH Lee JS
bullLinkhttpwwwncbinlmnihgovpubmed21179285
Comentario El articulo nos habla de el primer caso reportado por la metaacutestasis
cutaacutenea abdominal y el hipertiroidismo ocurrido por la manifestacioacuten inicial de la ATC en una mujer de 63 antildeos de edad que fue admitida en un hospital con una masa blanda de la pared abdominal de unos 15 cm de diaacutemetro que teniacutea por 1 mes Alrededor de 1 semana antes el paciente habiacutea percibido tambieacuten una misa en la zona del cuello La tomografiacutea computarizada reveloacute enormes masas de tiroides y periumbilical Los niveles de hormonas tiroideas eran compatibles con un estado de hipertiroidismo
1 httpbibliotecafucsaludeduco2052bookspagedoeid=4-u10-B978-0-323-05610-600017-2--s5360ampisbn=978-0-323-05610-6amptype=bookPageampsectionEid=4-u10-B978-0-323-05610-600017-2--s5360ampuniqId=235821444-144-u10-B978-0-323-05610-600017-2--s5360
2httpbibliotecafucsaludeduco2052dasarticlebody2358214449jorg=journalampsource=ampsp=15722101ampsid=0N4923641htmlissn=0002-838X
3 httpbibliotecafucsaludeduco2079ehostimageQuickViewsid=e4a56fd5-6fec-4ce9-acce3e707d09a138sessionmgr114ampvid=11ampui=6634823ampid=39764569ampparentui=39764569amptag=ANampdb=lth
4 httpbibliotecafucsaludeduco2052bookspagedoeid=4-u10-B978-0-323-05610-600017-2--s5360ampisbn=978-0-323-05610-6amptype=bookPageampsectionEid=4-u10-B978-0-323-05610-600017-2--s5360ampuniqId=235821444-144-u10-B978-0-323-05610-600017-2--s5360
5 httpbibliotecafucsaludeduco2052dasarticlebody235821444-14jorg=journalampsource=ampsp=15722101ampsid=0N4923641htmlissn=0002-838X
Bibliografia
Hyperthyroidism Diagnosis and Treatment
American Family Physician - Volume 72 Issue 4 (August 2005) - Copyright copy 2005 American Academy of Family Physicians
Hyperthyroidism in children and adolescents (English) By GODOY C CLAUDIA ACEVEDO M MARCELA BARRERA N ANTONIO YISMEYIAacuteN M ANAHIacute UGARTE P FRANCISCA Revista Chilena de Pediatriacutea enefeb2009 Vol 80 Issue 1 p21-29 9p 2 Charts 2 Graphs Language Spanish (AN 39764569)
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AbstractA 63-year-old female was admitted to our hospital with a tender abdominal wall mass about 15 cm in diameter which she had for 1 month About 1 week earlier the patient had also perceived a mass in the neck area Computed tomography revealed huge thyroid and periumbilical masses The thyroid hormone levels were consistent with a hyperthyroid state Pathological examination of the thyroid mass was compatible with anaplastic thyroid carcinoma (ATC) and the abdominal cutaneous mass was shown to be metastatic ATC Despite palliative radiotherapy and chemotherapy the patient died of respiratory failure on her 63rd day of hospitalization This case demonstrates that abdominal cutaneous metastasis and hyperthyroidism can occur as initial manifestations of ATC To our knowledge this is the first reported case
Anaplastic thyroid carcinoma initially presented with abdominal cutaneous mass and hyperthyroidism
bullAutoresLim KH Lee KW Kim JH Park SY Choi SH Lee JS
bullLinkhttpwwwncbinlmnihgovpubmed21179285
Comentario El articulo nos habla de el primer caso reportado por la metaacutestasis
cutaacutenea abdominal y el hipertiroidismo ocurrido por la manifestacioacuten inicial de la ATC en una mujer de 63 antildeos de edad que fue admitida en un hospital con una masa blanda de la pared abdominal de unos 15 cm de diaacutemetro que teniacutea por 1 mes Alrededor de 1 semana antes el paciente habiacutea percibido tambieacuten una misa en la zona del cuello La tomografiacutea computarizada reveloacute enormes masas de tiroides y periumbilical Los niveles de hormonas tiroideas eran compatibles con un estado de hipertiroidismo
1 httpbibliotecafucsaludeduco2052bookspagedoeid=4-u10-B978-0-323-05610-600017-2--s5360ampisbn=978-0-323-05610-6amptype=bookPageampsectionEid=4-u10-B978-0-323-05610-600017-2--s5360ampuniqId=235821444-144-u10-B978-0-323-05610-600017-2--s5360
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3 httpbibliotecafucsaludeduco2079ehostimageQuickViewsid=e4a56fd5-6fec-4ce9-acce3e707d09a138sessionmgr114ampvid=11ampui=6634823ampid=39764569ampparentui=39764569amptag=ANampdb=lth
4 httpbibliotecafucsaludeduco2052bookspagedoeid=4-u10-B978-0-323-05610-600017-2--s5360ampisbn=978-0-323-05610-6amptype=bookPageampsectionEid=4-u10-B978-0-323-05610-600017-2--s5360ampuniqId=235821444-144-u10-B978-0-323-05610-600017-2--s5360
5 httpbibliotecafucsaludeduco2052dasarticlebody235821444-14jorg=journalampsource=ampsp=15722101ampsid=0N4923641htmlissn=0002-838X
Bibliografia
Hyperthyroidism Diagnosis and Treatment
American Family Physician - Volume 72 Issue 4 (August 2005) - Copyright copy 2005 American Academy of Family Physicians
Hyperthyroidism in children and adolescents (English) By GODOY C CLAUDIA ACEVEDO M MARCELA BARRERA N ANTONIO YISMEYIAacuteN M ANAHIacute UGARTE P FRANCISCA Revista Chilena de Pediatriacutea enefeb2009 Vol 80 Issue 1 p21-29 9p 2 Charts 2 Graphs Language Spanish (AN 39764569)
httpdecsbvsbrcgi-binwxis1660exedecsserver
wwwmdconsultcom
wwwelseivercom
Anaplastic thyroid carcinoma initially presented with abdominal cutaneous mass and hyperthyroidism
bullAutoresLim KH Lee KW Kim JH Park SY Choi SH Lee JS
bullLinkhttpwwwncbinlmnihgovpubmed21179285
Comentario El articulo nos habla de el primer caso reportado por la metaacutestasis
cutaacutenea abdominal y el hipertiroidismo ocurrido por la manifestacioacuten inicial de la ATC en una mujer de 63 antildeos de edad que fue admitida en un hospital con una masa blanda de la pared abdominal de unos 15 cm de diaacutemetro que teniacutea por 1 mes Alrededor de 1 semana antes el paciente habiacutea percibido tambieacuten una misa en la zona del cuello La tomografiacutea computarizada reveloacute enormes masas de tiroides y periumbilical Los niveles de hormonas tiroideas eran compatibles con un estado de hipertiroidismo
1 httpbibliotecafucsaludeduco2052bookspagedoeid=4-u10-B978-0-323-05610-600017-2--s5360ampisbn=978-0-323-05610-6amptype=bookPageampsectionEid=4-u10-B978-0-323-05610-600017-2--s5360ampuniqId=235821444-144-u10-B978-0-323-05610-600017-2--s5360
2httpbibliotecafucsaludeduco2052dasarticlebody2358214449jorg=journalampsource=ampsp=15722101ampsid=0N4923641htmlissn=0002-838X
3 httpbibliotecafucsaludeduco2079ehostimageQuickViewsid=e4a56fd5-6fec-4ce9-acce3e707d09a138sessionmgr114ampvid=11ampui=6634823ampid=39764569ampparentui=39764569amptag=ANampdb=lth
4 httpbibliotecafucsaludeduco2052bookspagedoeid=4-u10-B978-0-323-05610-600017-2--s5360ampisbn=978-0-323-05610-6amptype=bookPageampsectionEid=4-u10-B978-0-323-05610-600017-2--s5360ampuniqId=235821444-144-u10-B978-0-323-05610-600017-2--s5360
5 httpbibliotecafucsaludeduco2052dasarticlebody235821444-14jorg=journalampsource=ampsp=15722101ampsid=0N4923641htmlissn=0002-838X
Bibliografia
Hyperthyroidism Diagnosis and Treatment
American Family Physician - Volume 72 Issue 4 (August 2005) - Copyright copy 2005 American Academy of Family Physicians
Hyperthyroidism in children and adolescents (English) By GODOY C CLAUDIA ACEVEDO M MARCELA BARRERA N ANTONIO YISMEYIAacuteN M ANAHIacute UGARTE P FRANCISCA Revista Chilena de Pediatriacutea enefeb2009 Vol 80 Issue 1 p21-29 9p 2 Charts 2 Graphs Language Spanish (AN 39764569)
httpdecsbvsbrcgi-binwxis1660exedecsserver
wwwmdconsultcom
wwwelseivercom
Comentario El articulo nos habla de el primer caso reportado por la metaacutestasis
cutaacutenea abdominal y el hipertiroidismo ocurrido por la manifestacioacuten inicial de la ATC en una mujer de 63 antildeos de edad que fue admitida en un hospital con una masa blanda de la pared abdominal de unos 15 cm de diaacutemetro que teniacutea por 1 mes Alrededor de 1 semana antes el paciente habiacutea percibido tambieacuten una misa en la zona del cuello La tomografiacutea computarizada reveloacute enormes masas de tiroides y periumbilical Los niveles de hormonas tiroideas eran compatibles con un estado de hipertiroidismo
1 httpbibliotecafucsaludeduco2052bookspagedoeid=4-u10-B978-0-323-05610-600017-2--s5360ampisbn=978-0-323-05610-6amptype=bookPageampsectionEid=4-u10-B978-0-323-05610-600017-2--s5360ampuniqId=235821444-144-u10-B978-0-323-05610-600017-2--s5360
2httpbibliotecafucsaludeduco2052dasarticlebody2358214449jorg=journalampsource=ampsp=15722101ampsid=0N4923641htmlissn=0002-838X
3 httpbibliotecafucsaludeduco2079ehostimageQuickViewsid=e4a56fd5-6fec-4ce9-acce3e707d09a138sessionmgr114ampvid=11ampui=6634823ampid=39764569ampparentui=39764569amptag=ANampdb=lth
4 httpbibliotecafucsaludeduco2052bookspagedoeid=4-u10-B978-0-323-05610-600017-2--s5360ampisbn=978-0-323-05610-6amptype=bookPageampsectionEid=4-u10-B978-0-323-05610-600017-2--s5360ampuniqId=235821444-144-u10-B978-0-323-05610-600017-2--s5360
5 httpbibliotecafucsaludeduco2052dasarticlebody235821444-14jorg=journalampsource=ampsp=15722101ampsid=0N4923641htmlissn=0002-838X
Bibliografia
Hyperthyroidism Diagnosis and Treatment
American Family Physician - Volume 72 Issue 4 (August 2005) - Copyright copy 2005 American Academy of Family Physicians
Hyperthyroidism in children and adolescents (English) By GODOY C CLAUDIA ACEVEDO M MARCELA BARRERA N ANTONIO YISMEYIAacuteN M ANAHIacute UGARTE P FRANCISCA Revista Chilena de Pediatriacutea enefeb2009 Vol 80 Issue 1 p21-29 9p 2 Charts 2 Graphs Language Spanish (AN 39764569)
httpdecsbvsbrcgi-binwxis1660exedecsserver
wwwmdconsultcom
wwwelseivercom
1 httpbibliotecafucsaludeduco2052bookspagedoeid=4-u10-B978-0-323-05610-600017-2--s5360ampisbn=978-0-323-05610-6amptype=bookPageampsectionEid=4-u10-B978-0-323-05610-600017-2--s5360ampuniqId=235821444-144-u10-B978-0-323-05610-600017-2--s5360
2httpbibliotecafucsaludeduco2052dasarticlebody2358214449jorg=journalampsource=ampsp=15722101ampsid=0N4923641htmlissn=0002-838X
3 httpbibliotecafucsaludeduco2079ehostimageQuickViewsid=e4a56fd5-6fec-4ce9-acce3e707d09a138sessionmgr114ampvid=11ampui=6634823ampid=39764569ampparentui=39764569amptag=ANampdb=lth
4 httpbibliotecafucsaludeduco2052bookspagedoeid=4-u10-B978-0-323-05610-600017-2--s5360ampisbn=978-0-323-05610-6amptype=bookPageampsectionEid=4-u10-B978-0-323-05610-600017-2--s5360ampuniqId=235821444-144-u10-B978-0-323-05610-600017-2--s5360
5 httpbibliotecafucsaludeduco2052dasarticlebody235821444-14jorg=journalampsource=ampsp=15722101ampsid=0N4923641htmlissn=0002-838X
Bibliografia
Hyperthyroidism Diagnosis and Treatment
American Family Physician - Volume 72 Issue 4 (August 2005) - Copyright copy 2005 American Academy of Family Physicians
Hyperthyroidism in children and adolescents (English) By GODOY C CLAUDIA ACEVEDO M MARCELA BARRERA N ANTONIO YISMEYIAacuteN M ANAHIacute UGARTE P FRANCISCA Revista Chilena de Pediatriacutea enefeb2009 Vol 80 Issue 1 p21-29 9p 2 Charts 2 Graphs Language Spanish (AN 39764569)
httpdecsbvsbrcgi-binwxis1660exedecsserver
wwwmdconsultcom
wwwelseivercom
Hyperthyroidism Diagnosis and Treatment
American Family Physician - Volume 72 Issue 4 (August 2005) - Copyright copy 2005 American Academy of Family Physicians
Hyperthyroidism in children and adolescents (English) By GODOY C CLAUDIA ACEVEDO M MARCELA BARRERA N ANTONIO YISMEYIAacuteN M ANAHIacute UGARTE P FRANCISCA Revista Chilena de Pediatriacutea enefeb2009 Vol 80 Issue 1 p21-29 9p 2 Charts 2 Graphs Language Spanish (AN 39764569)
httpdecsbvsbrcgi-binwxis1660exedecsserver
wwwmdconsultcom
wwwelseivercom