what is restasis - aao.org
TRANSCRIPT
Q
What is Restasis?
1
Restasis
A
What is Restasis? Topical cyclosporine
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Restasis
Q
What is Restasis? Topical cyclosporine Broadly speaking, what sort of drug is it?
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Restasis
A4
What is Restasis? Topical cyclosporine Broadly speaking, what sort of drug is it? What
effect does it have? An immunomodulatory drug
Restasis
Q
What is Restasis? Topical cyclosporine Broadly speaking, what sort of drug is it? What
effect does it have? An immunomodulatory drug
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Restasis
A
What is Restasis? Topical cyclosporine Broadly speaking, what sort of drug is it? What
effect does it have? An immunomodulatory drug. It downregulates T-cell-mediated inflammation.
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Restasis
Q
What is Restasis? Topical cyclosporine Broadly speaking, what sort of drug is it? What
effect does it have? An immunomodulatory drug. It downregulates T-cell-mediated inflammation.
How long does it take to work?
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Restasis
A
What is Restasis? Topical cyclosporine Broadly speaking, what sort of drug is it? What
effect does it have? An immunomodulatory drug. It downregulates T-cell-mediated inflammation.
How long does it take to work? At least 3 months (often 6 months for full effect)
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Restasis
Q
What is Restasis? Topical cyclosporine Broadly speaking, what sort of drug is it? What
effect does it have? An immunomodulatory drug. It downregulates T-cell-mediated inflammation.
How long does it take to work? At least 3 months (often 6 months for full effect)
Why so long?
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Restasis
A
What is Restasis? Topical cyclosporine Broadly speaking, what sort of drug is it? What
effect does it have? An immunomodulatory drug. It downregulates T-cell-mediated inflammation.
How long does it take to work? At least 3 months (often 6 months for full effect)
Why so long? Probably related to the length of the T-cell life cycle (about 120 days)
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Restasis
Q
Prednisoloneacetate 1% Restasis
Cataractogenic? Yes No
Inhibits epithelial healing? Yes No
Glaucomagenic? Yes No
Potentiates HSV infection? Yes No
Increases risk of fungal
keratopathy?Yes No
Restasis vs Steroids: The good news…
11
Restasis
A
Prednisoloneacetate 1% Restasis
Cataractogenic? Yes No
Inhibits epithelial healing? Yes No
Glaucomagenic? Yes No
Potentiates HSV infection? Yes No
Increases risk of fungal
keratopathy?Yes No
Restasis vs Steroids: The good news…
12
Restasis
Q
Prednisoloneacetate 1% Restasis
Cataractogenic? Yes No
Inhibits epithelial healing? Yes No
Glaucomagenic? Yes No
Potentiates HSV infection? Yes No
Increases risk of fungal
keratopathy?Yes No
Restasis vs Steroids: The good news…
13
Restasis
A
Prednisoloneacetate 1% Restasis
Cataractogenic? Yes No
Inhibits epithelial healing? Yes No
Glaucomagenic? Yes No
Potentiates HSV infection? Yes No
Increases risk of fungal
keratopathy?Yes No
Restasis vs Steroids: The good news…
14
Restasis
Q
Prednisoloneacetate 1% Restasis
Cataractogenic? Yes No
Inhibits epithelial healing? Yes No
Glaucomagenic? Yes No
Potentiates HSV infection? Yes No
Increases risk of fungal
keratopathy?Yes No
Restasis vs Steroids: The good news…
15
Restasis
A
Prednisoloneacetate 1% Restasis
Cataractogenic? Yes No
Inhibits epithelial healing? Yes No
Glaucomagenic? Yes No
Potentiates HSV infection? Yes No
Increases risk of fungal
keratopathy?Yes No
Restasis vs Steroids: The good news…
16
Restasis
Q
Prednisoloneacetate 1% Restasis
Cataractogenic? Yes No
Inhibits epithelial healing? Yes No
Glaucomagenic? Yes No
Potentiates HSV infection? Yes No
Increases risk of fungal
keratopathy?Yes No
Restasis vs Steroids: The good news…
17
Restasis
A
Prednisoloneacetate 1% Restasis
Cataractogenic? Yes No
Inhibits epithelial healing? Yes No
Glaucomagenic? Yes No
Potentiates HSV infection? Yes No
Increases risk of fungal
keratopathy?Yes No
Restasis vs Steroids: The good news…
18
Restasis
Q
Prednisoloneacetate 1% Restasis
Cataractogenic? Yes No
Inhibits epithelial healing? Yes No
Glaucomagenic? Yes No
Potentiates HSV infection? Yes No
Increases risk of fungal
keratopathy?Yes No
Restasis vs Steroids: The good news…
19
Restasis
A
Prednisoloneacetate 1% Restasis
Cataractogenic? Yes No
Inhibits epithelial healing? Yes No
Glaucomagenic? Yes No
Potentiates HSV infection? Yes No
Increases risk of fungal
keratopathy?Yes No
Restasis vs Steroids: The good news…
20
Restasis
Q
Prednisoloneacetate 1% Restasis
Cataractogenic? Yes No
Inhibits epithelial healing? Yes No
Glaucomagenic? Yes No
Potentiates HSV infection? Yes No
Increases risk of fungal
keratopathy?Yes No
Prednisolone acetate 1% Restasis
Expensive? No Yes
Slow to work? No Yes
Stings/burns? No Yes
Reduces risk of PK rejection? Yes No
Generic available? Yes No
…and the badRestasis vs Steroids: The good news…
21
Restasis
A
Prednisoloneacetate 1% Restasis
Cataractogenic? Yes No
Inhibits epithelial healing? Yes No
Glaucomagenic? Yes No
Potentiates HSV infection? Yes No
Increases risk of fungal
keratopathy?Yes No
Prednisolone acetate 1% Restasis
Expensive? No Yes
Slow to work? No Yes
Stings/burns? No Yes
Reduces risk of PK rejection? Yes No
Generic available? Yes No
…and the badRestasis vs Steroids: The good news…
22
Restasis
Q
Prednisoloneacetate 1% Restasis
Cataractogenic? Yes No
Inhibits epithelial healing? Yes No
Glaucomagenic? Yes No
Potentiates HSV infection? Yes No
Increases risk of fungal
keratopathy?Yes No
Prednisolone acetate 1% Restasis
Expensive? No Yes
Slow to work? No Yes
Stings/burns? No Yes
Reduces risk of PK rejection? Yes No
Generic available? Yes No
…and the badRestasis vs Steroids: The good news…
23
Restasis
A
Prednisoloneacetate 1% Restasis
Cataractogenic? Yes No
Inhibits epithelial healing? Yes No
Glaucomagenic? Yes No
Potentiates HSV infection? Yes No
Increases risk of fungal
keratopathy?Yes No
Prednisolone acetate 1% Restasis
Expensive? No Yes
Slow to work? No Yes
Stings/burns? No Yes
Reduces risk of PK rejection? Yes No
Generic available? Yes No
…and the badRestasis vs Steroids: The good news…
24
Restasis
Q
Prednisoloneacetate 1% Restasis
Cataractogenic? Yes No
Inhibits epithelial healing? Yes No
Glaucomagenic? Yes No
Potentiates HSV infection? Yes No
Increases risk of fungal
keratopathy?Yes No
Prednisolone acetate 1% Restasis
Expensive? No Yes
Slow to work? No Yes
Stings/burns? No Yes
Reduces risk of PK rejection? Yes No
Generic available? Yes No
…and the badRestasis vs Steroids: The good news…
25
Restasis
A
Prednisoloneacetate 1% Restasis
Cataractogenic? Yes No
Inhibits epithelial healing? Yes No
Glaucomagenic? Yes No
Potentiates HSV infection? Yes No
Increases risk of fungal
keratopathy?Yes No
Prednisolone acetate 1% Restasis
Expensive? No Yes
Slow to work? No Yes
Stings/burns? No Yes
Reduces risk of PK rejection? Yes No
Generic available? Yes No
…and the badRestasis vs Steroids: The good news…
26
Restasis
Q
Prednisoloneacetate 1% Restasis
Cataractogenic? Yes No
Inhibits epithelial healing? Yes No
Glaucomagenic? Yes No
Potentiates HSV infection? Yes No
Increases risk of fungal
keratopathy?Yes No
Prednisolone acetate 1% Restasis
Expensive? No Yes
Slow to work? No Yes
Stings/burns? No Yes
Reduces risk of PK rejection? Yes No
Generic available? Yes No
…and the badRestasis vs Steroids: The good news…
27
Restasis
A
Prednisoloneacetate 1% Restasis
Cataractogenic? Yes No
Inhibits epithelial healing? Yes No
Glaucomagenic? Yes No
Potentiates HSV infection? Yes No
Increases risk of fungal
keratopathy?Yes No
Prednisolone acetate 1% Restasis
Expensive? No Yes
Slow to work? No Yes
Stings/burns? No Yes
Reduces risk of PK rejection? Yes No
Generic available? Yes No
…and the badRestasis vs Steroids: The good news…
28
Restasis
Q
Prednisoloneacetate 1% Restasis
Cataractogenic? Yes No
Inhibits epithelial healing? Yes No
Glaucomagenic? Yes No
Potentiates HSV infection? Yes No
Increases risk of fungal
keratopathy?Yes No
Prednisolone acetate 1% Restasis
Expensive? No Yes
Slow to work? No Yes
Stings/burns? No Yes
Reduces risk of PK rejection? Yes No
Generic available? Yes No
…and the badRestasis vs Steroids: The good news…
29
Restasis
A
Prednisoloneacetate 1% Restasis
Cataractogenic? Yes No
Inhibits epithelial healing? Yes No
Glaucomagenic? Yes No
Potentiates HSV infection? Yes No
Increases risk of fungal
keratopathy?Yes No
Prednisolone acetate 1% Restasis
Expensive? No Yes
Slow to work? No Yes
Stings/burns? No Yes
Reduces risk of PK rejection? Yes No
Generic available? Yes No
…and the badRestasis vs Steroids: The good news…
30
Restasis