total bronchoscopy: 110 adeno: 43

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Total bronchoscopy: 110 Adeno: 43 17 Yes vs. 14 No Male: 15 Female: 3 Male: 3 Female: 13 Total Surgery: 62 Adeno: 38 8 Yes vs. 23 No Male: 6 Female: 2 Male: 5 Female: 18 Microarray data analysis of adeno- samples

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Microarray data analysis of adeno- samples. Total Surgery: 62 Adeno: 38. Total bronchoscopy: 110 Adeno: 43. 8 Yes vs. 23 No. 17 Yes vs. 14 No. Male: 5 Female: 18. Male: 6 Female: 2. Male: 3 Female: 13. Male: 15 Female: 3. - PowerPoint PPT Presentation

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  • Microarray data analysis of adeno- samples

  • Male-adeno-(surgery): smokers (6) vs. nonsmokers (5)26 genes

    Number of genes(FDR

  • Male-adeno-(surgery): smokers vs. nonsmokersCancer cells generally exhibit increased glycolysis for ATP generation due in part to mitochondrial respiration injury and hypoxia, which are frequently associated with resistance to therapeutic agents.

    ABI2CDC42BPACHRNA5ENO1GNB2L1IGFBP3NR4A2PGK1PKM2POLE3STIP1TRRAP

  • Male-adeno-(surgery): smokers vs. nonsmokers

  • Male-adeno-(surgery): smokers vs. nonsmokers

  • Male-adeno-(surgery): smokers vs. nonsmokers

  • Male-adeno-(Bronchoscopy): smokers (15) vs. nonsmokers (3)

    Number of genes(FDR

  • Male-adeno-(Bronchoscopy): smokers vs. nonsmokers

  • Male-adeno-(Bronchoscopy): smokers vs. nonsmokers

  • Male-adeno-(Bronchoscopy): smokers vs. nonsmokers

  • Male-adeno-(Bronchoscopy): smokers vs. nonsmokers

  • Male-adeno-(bronchoscopy+surgery): smokers (21) vs. nonsmokers (8)

    Probeset IDGene TitleGene Symbolp-value(Yes vs. No)Fold-Change(Yes vs. No)206211_atselectin E (endothelial adhesion molecule 1)SELE3.46E-06-1.80541221031_s_atapolipoprotein L domain containing 1APOLD11.06E-05-2.19057219371_s_atKruppel-like factor 2 (lung)KLF24.40E-05-2.08101211343_s_atcollagen, type XIII, alpha 1COL13A10.000171-2.31043214057_atMyeloid cell leukemia sequence 1 (BCL2-related)MCL10.000181-1.62716203373_atsuppressor of cytokine signaling 2SOCS20.000184-2.22292205656_atprotocadherin 17PCDH170.000586-2.29517209967_s_atcAMP responsive element modulatorCREM0.000735-1.6904202237_atnicotinamide N-methyltransferaseNNMT0.000942-3.33361202499_s_atsolute carrier family 2 (facilitated glucose transporter), member 3SLC2A30.001003-3.03379220296_atUDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferaseGALNT100.001144-1.81426212009_s_atstress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein)STIP10.0012071.89047202388_atregulator of G-protein signaling 2, 24kDaRGS20.001324-2.55253217140_s_atvoltage-dependent anion channel 1VDAC10.0017312.04997209795_atCD69 moleculeCD690.001976-2.26674

  • Male-adeno-(bronchoscopy+surgery): smokers vs. nonsmokers

  • Male-adeno-(bronchoscopy+surgery): smokers vs. nonsmokers

  • Female-adeno-(bronchoscopy): smokers (3) vs. nonsmokers (10)20 genes

    Probeset IDGene TitleGene Symbolp-value(Yes vs. No)Fold-Change(Yes vs. No)201387_s_atubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)UCHL10.0004727.06813201651_s_atprotein kinase C and casein kinase substrate in neurons 2PACSIN20.000578-2.00301220714_atPR domain containing 14PRDM140.0007291.34103209784_s_atjagged 2JAG20.000825-2.41471220445_s_atCSAG family, member 3A /// CSAG family, member 3BCSAG3A /// CSAG3B0.0010963.37814221484_atUDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5B4GALT50.001759-2.50862201625_s_atinsulin induced gene 1INSIG10.0020031.65578206176_atbone morphogenetic protein 6BMP60.0020941.54374222240_s_atmyo-inositol 1-phosphate synthase A1ISYNA10.00272-1.68393201582_atSec23 homolog B (S. cerevisiae)SEC23B0.002772.03293214603_atmelanoma antigen family A, 2 /// melanoma antigen family A, 2BMAGEA2 /// MAGEA2B0.0028973.33431203379_atribosomal protein S6 kinase, 90kDa, polypeptide 1RPS6KA10.003213-1.68547209881_s_atlinker for activation of T cellsLAT0.003815-1.4298209870_s_atamyloid beta (A4) precursor protein-binding, family A, member 2 (X11-like)APBA20.003853-1.41295212717_atpleckstrin homology domain containing, family M (with RUN domain) member 1PLEKHM10.004155-1.79873201403_s_atmicrosomal glutathione S-transferase 3MGST30.004182.03199204067_atsulfite oxidaseSUOX0.0042891.73442204465_s_atinternexin neuronal intermediate filament protein, alphaINA0.0044591.96424201690_s_attumor protein D52TPD520.0046832.86792217927_atsignal peptidase complex subunit 1 homolog (S. cerevisiae)SPCS10.0047461.98047

  • Female-adeno-(bronchoscopy): smokers vs. nonsmokers

  • Female-adeno-(bronchoscopy): smokers vs. nonsmokers

  • Female-adeno-(bronchoscopy): smokers vs. nonsmokers

  • Female-adeno-(Surgery): smokers (2) vs. nonsmokers (18)

  • Female-adeno-(bronchoscopy+surgery): smokers (31) vs. nonsmokers (5)

    Probeset IDGene TitleGene Symbolp-value(Yes vs. No)Fold-Change(Yes vs. No)220445_s_atCSAG family, member 3A /// CSAG family, member 3BCSAG3A /// CSAG3B0.0002152.13869206478_atKIAA0125KIAA01250.0002582.01833201938_atCDK2-associated protein 1CDK2AP10.0002741.79749214254_atmelanoma antigen family A, 4MAGEA40.0003311.75414214612_x_atmelanoma antigen family A, 6MAGEA60.0003453.99952203233_atinterleukin 4 receptorIL4R0.000504-1.80242209942_x_atmelanoma antigen family A, 3MAGEA30.0007084.06968201382_atcalcyclin binding proteinCACYBP0.0008381.18307210293_s_atSec23 homolog B (S. cerevisiae)SEC23B0.0008541.51336205848_atgrowth arrest-specific 2GAS20.0008841.46057

  • Female-adeno-(bronchoscopy+surgery): smokers vs. nonsmokers

  • Female-adeno-(bronchoscopy+surgery): smokers vs. nonsmokers

  • GSE10072nm1790

    ContrastNumber of genes(FDR