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    Anatomy - The Study of Form

    Examining structure of the Human Body inspection

    palpation

    auscultation

    percussion

    Cadaver dissection cutting and separation of tissues to reveal their

    relationships

    Comparative anatomy study of more than one species in order to examine

    structural similarities and differences, and analyze

    evolutionary trends

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    Exploratory Surgery

    open body and take a look inside

    Medical imaging viewing the inside of the body without surgery

    Radiologybranch of medicine concerned with imaging

    Gross Anatomy study of structures that can be seen with the naked eye

    Cytology study of structure and function of cells

    Histology (microscopic anatomy) examination of cells with microscope

    Ultrastructure the molecular detail seen in electron microscope

    Histopathology

    microscopic examination of tissues for signs of disease

    Anatomy - The Study of Form

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    Physiology - The Study ofFunction

    Subdisciplines

    neurophysiology (physiology of nervous system)

    endocrinology (physiology of hormones)

    pathophysiology (mechanisms of disease)

    Comparative Physiology

    limitations on human experimentation

    study of different species to learn about bodily function animal surgery

    animal drug tests

    basis for the development of new drugs and medical

    procedures

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    Hierarchy of Complexity Organism a single, complete individual

    Organ Systemhuman body made of 11 organ systems

    Organstructure composed of two or more tissue types that work together to carryout a particular function

    Tissuea mass of similar cells and cell products that form discrete region of anorgan and performs a specific function

    Cells the smallest units of an organism that carry out all the basic functions of life Cytology the study of cells and organelles

    Organelles

    microscopic structures in a cell that carry out its individual functions

    Moleculesmake up organelles and other cellular components

    macromolecules proteins, carbohydrates, fats, DNA

    Atomsthe smallest particles with unique chemical identities1-4

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    Characteristics of Life Organization

    Cellular composition

    Metabolism

    anabolism, catabolism and excretion

    Responsiveness and movement

    stimuli

    Homeostasis

    Development

    differentiation and growth

    Reproduction

    Evolution

    mutations

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    Physiological Variation

    Sex, age, diet, weight, physical activity

    Typical physiological values

    reference man 22 years old, 154 lbs, light physical activity

    consumes 2800 kcal/day

    reference woman

    same as man except 128 lbs and 2000 kcal/day

    Overmedication of elderly

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    Homeostasis Homeostasisthe bodys ability to detect change,

    activate mechanisms that oppose it, and thereby maintainrelatively stable internal conditions

    Claude Bernard (1813-78) constant internal conditions regardless of external

    conditions internal body temperature ranges from 97 to 99 degrees despitevariations in external temperature

    Walter Cannon (1871-1945) coined the term Homeostasis

    state of the body fluctuates (dynamic equilibrium) withinlimited range around a set point

    Negative feedback keeps variable close to the set point

    Loss of homeostatic control causes illness

    or death

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    Negative Feedback in HumanThermoregulation

    Brain senses change in blood temperature

    if to warm, vessels dilate (vasodilation) in the skin and sweatingbegins (heat losing mechanisms)

    if too cold, vessels in the skin constrict (vasoconstriction)and shivering begins (heat gaining mechanism)

    Time

    Sweating

    Set point

    Vasoconstriction

    Vasodilation

    36.5C

    (97.7F)

    37.0C

    (98.6F)

    37.5C(99.5F)

    Shivering

    Corebodytemperature

    Copyright The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

    Figure 1.10

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    Negative Feedback Control ofBlood Pressure

    Sitting up in bed causes a drop in blood pressurein the head and upper thorax

    Baroreceptors in the arteries near the heart alert

    the cardiac center in the brainstem

    Cardiac center sends nerve signals that increasethe heart rate and return the blood pressure to

    normal Failure of this to feedback loop may produce

    dizziness in the elderly

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    3 Components of a FeedbackLoop

    Receptor - senses change in the body

    Integrating (Control) Center - controlcenter that processes the sensoryinformation, makes a decision, anddirects the response

    Effectorcarries out the final correctiveaction to restore homeostasis

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    Positive Feedback Loops Self-amplifying cycle

    leads to greater change in the same direction feedback loop is repeated change produces more change

    Normal way of producing rapid changes occurs with childbirth, blood clotting, protein digestion, fever, and

    generation of nerve signals

    Head of fetus

    pushes against cervix

    2

    3

    4

    1

    Oxytocin stimulates uterine

    contractions and pushes

    fetus toward cervix

    Nerve impulses

    from cervix

    Transmitted

    to brain

    Brain stimulates

    pituitary gland to

    secrete oxytocin

    Copyright The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

    Figure 1.12

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    Harmful Positive Feedback Loop

    Fever > 104 degrees F

    metabolic rate increases

    body produces heat even faster

    body temperature continues to rise

    further increasing metabolic rate

    Cycle continues to reinforce itself

    Becomes fatal at 113 degrees F

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    Importance of Precision

    Be precise in your terms

    Spell correctly

    Health Care professions demand thesame type of precision

    Peoples lives will be in your hands

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    Review of Major Themes

    Cell Theory All structure and function result from the activity of cells

    Homeostasis The purpose of most normal physiology is to maintain stable

    conditions within the body

    Evolution The human body is a product of evolution

    Hierarchy of Structure Human structure can be viewed as a series of levels of complexity

    Unity of Form and Function Form and function complement each other; physiology cannot be

    divorced from anatomy

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    Medical Imaging

    Radiography (x rays)

    William Roentgen - 1885

    penetrate tissues to

    darken photographic filmbeneath the body

    dense tissue appearswhite

    over half of all medicalimaging

    until 1960s, it was the only

    method widely available

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    Medical Imaging

    Radiopaque substances

    injected or swallowed

    fills hollow structures

    blood vessels

    intestinal tract

    (b) Cerebral angiogramCustom Medical Stock Photo, Inc.

    Copyright The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

    Figure 1.13b

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    Medical Imaging

    ComputedTomography (CTscan)

    formerly called a CATscan

    low-intensity X raysand computer analysis

    slice type image increased

    sharpness of image

    Figure 1.13c

    (c) Computed tomographic (CT) scan

    CNR/Phototake

    Copyright The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

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    Medical Imaging - Nuclear Medicine

    Positron Emission Tomography (PET scan)

    assesses metabolic state of tissue

    distinguished tissues most active at a

    given moment mechanics

    inject radioactively labeled glucose

    positrons and electrons collide

    gamma rays given off detected by sensor

    analyzed by computer

    image color shows which tissues

    were using the most glucose at that moment

    damaged tissues appear dark

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    Medical Imaging

    Magnetic ResonanceImaging (MRI)

    slice type image

    superior quality to CT scan

    best for soft tissue

    mechanics

    alignment & realignment ofhydrogen atoms withmagnetic field & radio waves

    varying levels of energygiven off used by computerto produce an image

    (e) Magnetic resonance image (MRI)

    Copyright The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

    Monte S. Buchsbaum, Mt. Sinai School of Medicine, New York, NY

    Figure 1.13e