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Page 1: Dioxin Hot Spot Study

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Serum Dioxin Levels in Vietnamese Men more than 40 Years after

Herbicide Spraying

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Other ACS content by theseauthors:

Ho Dung Manh

Teruhiko Kido

Rie Okamoto

Sun XianLiang

Le Thai Anh

Supratman SupratmanShoko Maruzeni

Muneko Nishijo

Hideaki Nakagawa

Seijiro Honma

Takeshi Nakano

Takumi Takasuga

Dang Duc Nhu

Nguyen Ngoc Hung

Le Ke Son

Article

 

Environ. Sci. Technol. Environ. Sci. Technol. Lett.

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Abstract

Ho Dung Manh †‡, Teruhiko Kido §*, Rie Okamoto §,

Sun XianLiang †, Le Thai Anh †, Supratman

Supratman †, Shoko Maruzeni , Muneko Nishijo ,

Hideaki Nakagawa , Seijiro Honma , TakeshiNakano #, Takumi Takasuga , Dang Duc Nhu ▲,

Nguyen Ngoc Hung ▲, and Le Ke Son ■† Division of Health Sciences, Graduate School of 

Medical Science, Kanazawa University, 5-11-80

Kodatsuno, Kanazawa 920-8640, Japan‡ Faculty of Environmental Engineering and

Biotechnology, Lac Hong University, No.10 Huynh Van Nghe, Buu Long, Bien Hoa, Dong Nai, Vietnam§ Faculty of Health Sciences, Institute of Medical Pharmaceutical and Health Sciences, Kanazawa

University, 5-11-80 Kodatsuno, Kanazawa 920-8640, Japan

 Department of Public Health, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa 920-

8641, Japan

 ASKA Pharma Medical Co. Ltd., 5-36-1 Shimosakunobe, Kawasaki 213-8522, Japan#  Center for Advanced Science and Innovation, Osaka University, Osaka 560-0043, Japan

 Shimadzu Techno-Research Inc., Kyoto 604-8435, Japan▲ 10-80 Division, Hanoi Medical University, No.1 Ton That Tung, Dong Da, Hanoi, Vietnam■ Environment Administration, Ministry of Natural Resources and Environment, 67 Nguyen Du Street,

Hanoi, Vietnam

Environ. Sci. Technol., Article ASAP

DOI: 10.1021/es404853h

Publication Date (Web): February 19, 2014

Copyright © 2014 American Chemical Society

*Tel: +81-76-265-2565; fax+81-76-265-2565; e-mail: [email protected].

 Author Present Address

School of Medicine and Pharmacy, Vietnam National University, 144 Xuan Thuy, Cau Giay, Hanoi,Vietnam

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Manh, Ho Dung

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History

Just Accepted ManuscriptFebruary 19, 2014

Received: October 30, 2013Accepted: February 19, 2014

Revised: February 15, 2014

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Recent studies have found elevated dioxin levels inside some U.S. military former air bases

in Vietnam, known as hotspots. Many studies of Agent Orange have been done in U.S.

veterans; however, there is little known about Vietnamese men. In 2010, we collected blood

samples from 97 men in a hotspot and 85 men in an unsprayed area in Northern Vietnam.Serum concentrations of not only TCDD but also other dioxins (PCDDs), furans (PCDFs), and

nonortho polychlorinated biphenyls (PCBs) were significantly higher in the hotspot than in

the unsprayed area. In the hotspot, three subareas were demarcated, based on their

proximity to the air base. The total toxic equivalents (TEQ) of PCDDs/PCDFs+PCBs was 41.7

pg/g lipid in the area closest to the air base, while it was around 29 pg/g lipid in the other

two subareas. In the unsprayed area, the dioxin levels were no different between men who

went to the South during the Vietnam War and those who remained in the North, with TEQs

PCDDs/PCDFs+PCBs of around 13.6 pg/g lipid. Our findings suggested that people living close

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to the former U.S. air bases might have been exposed to both Agent Orange and other

sources of dioxin-like compounds.

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