exam review: march 9, 2010 50113xm1review.ppt first hourly exam 100 pts updated: february 13, 2014...

Exam Review: March 9, 2010

50113Xm1Review.PPt

First Hourly Exam 100 Pts

Updated: February 13, 2014

501IntroClinical

EpidemioDefClassModels

Intro501: Introduction to Cancer Biology and to the Course

(501Intro.ppt)

Figure 1.11a The Biology of Cancer (© Garland Science 2007)

Banding pattern of normal metaphase human chromosomes

Figure 1.11b The Biology of Cancer (© Garland Science 2007)

Fluorescent in situ hybridization (FISH) of normal metaphase human chromosomes

using chromosome specific DNA probes with different fluorescent dyes

Figure 1.11c The Biology of Cancer (© Garland Science 2007)

Aneuploid karyotype of human breast cancer cell.

Note “scrambling” of colors demonstrating chromosomal reciprocal translocations

Figure 1.11d The Biology of Cancer (© Garland Science 2007)

Intra-chromosonal inversion by M-band fluorescent in situ hybridization(mFISH)


Cytoskeleton:

Actin microfilaments

Microtubules

Intermediate filaments


Intermediate Filaments of epithelial cell (keratin) in green

Plasma membrane in blue

Figure 1.14d The Biology of Cancer (© Garland Science 2007)

3T3 Mouse Fibroblast attached to fibronectin extra-cellular matrix by integrin receptors

What Models of Cancers Do We Actually Use in Cancer Biology and Cancer Medicine?

Neoplastic and Normal Cell Lines in CultureTransformed Normal CellsFreshly-derived Cancer CellsGenetically Engineered CellsEngineered Tissues (3-Dimensional Cell Cultures)Animal Models in Cancer Research and Cancer Medicine

(“Pre-Clinical Trials”)Inbred Animal ModelsVeterinary AnimalsAnimal-Human Engineered Hybrid Models

Clinical Cancer in PatientsClinical Trials (Phase I, Phase II, and Phase III)Dr. Steve Graziano: Lung Cancer Therapy(Last week of class)

About Kuyler Van Nocker

and

Neuroblastoma

http://www.msnbc.msn.com/id/3036677/#39049661

Cancer Biology and Clinical TreatmentThe Impact of the Health-care System


Cancer Treatment | PBS NewsHour | Jan. 1, 2001 | PBSJan 1, 2001 ... ELIZABETH BRACKETT: Last year, Kelley Mitchell lost her battle against cancer. But before the 16-year-old died, she agreed to try a highly ...www.pbs.org/newshour/bb/health/jan-june01/cancer_01-01.html

Week Two: The Story of Kelley Mitchell and Ewings Sarcoma

Last Presentation: The Story of Taylor Black and Neuroblastoma(“Daydreams and Diaries” - UntreedReads.comOnLine Story of Taylor Black by Tim Black)

Clinical Presentation of Cancers

(Clinical.ppt)

Introduction of PSA (prostate specific antigen) test to screen for prostate cancer

See Figure 11.1, Cancer incidence at various ages for men and women. p. 400. Weinberg.

Note maximum incidence per 100,000 population at about age 70, then drop off after that age. Serious incidence begins around age 35 except for breast cancer which can have an earlier onset depending on genetics.

Incidence of Various Kinds of Cancers in Men and Women as a Function of Age

Figure 16.45c The Biology of Cancer (© Garland Science 2007)

Epidemiology of Cancers

(Epidemio.ppt)

Figure 4.12 The Biology of Cancer (© Garland Science 2007)

Incidence of Burkitt’s Lymphoma in Relation to Infectious Disease Etiology:Aedes simpsoni mosquito transmission vector for malaria and Epstein Barr Virus co-infection


Cancer Incidence Following Migration

p. 45

CigBooze

Definitions of Classifications of Cancer

(DefClass.ppt)

Normal Secretory & Ciliated Epithelial Cells

Figure 16-19, ECB, 1998, p. 528RespCilia

Ciliated Epithelium ofHuman Respiratory Tract


Prpgression in Neoplastic Development: Weinberg, Chapter 11 on Multistep Tumorigenesis. Figure 11.7

Cancer Incidence 2002: 1,285,000. Cancer Deaths 555,000. 43% Death RateCancer Incidence 2009: 1,479,000. Cancer Deaths 562,000. 38% Death Rate

Table 2.3 The Biology of Cancer (© Garland Science 2007)p. 33

Hematopoiesis (formation of blood cells)Fig 2-1, Kuby 4th Ed. p. 28

HematoAll

Pluripotent Stem Celland Lymphoid andMyeloid Lineages

(Fig 2-1, Kuby 4th Ed. p. 28

Myeloid Stem Cell

StemCell

Lymphoid Lineage

Fig 2-1 Kuby 4th Ed

p. 28

MyeloidLineage(Kuby, Fig 2-1,4th Ed., p. 28)

Myeloid


Disease Progression in Chronic Myelogenous Leukemia

p. 293

Model Systems in the Study of Cancers

(Models.ppt)

Figure 13.8 The Biology of Cancer (© Garland Science 2007) p. 539

Primary excised surgical tumor pieces

Surgical specimens after 3 to 6 months growth sub-cutaneously in SCID Mice

Prostate and colon cancer cell lines propagated in vitro and implanted

Comparisons of Two Primary Cancers vs the Cancers Propagated as Model Systems

Cancer Comparisons

Cancer Model Systems In Vitro(in Cell, Tissue, or Organ Culture)

Normal Cells in Culture• Transformed Cells Chemically Virally By Irradiation• Neoplastic Cells from Animal Tumors• Neoplastic Cells Cultured from Human

Cancers

CxVitro

Animal Tumor Models in VivoSource of the Tumor Challenge Cells

• Implanted Cultured Neoplastic Cells

• Transplanted from Donor Animals

Early vs Later Transplant Generations

• Induced in the Tumor-bearing Host Animals

Spontaneous (by Genetic Selection)

Chemical, Viral, Radiation Induction

• Excised fromVeterinaryAnimalsAnimlCx1

Clinical Human Cancers as "Model" Systems

Advantages:• The Closest "Model" to the Ultimate Goals ...The Best Model for Human Cancer• Patient Feed-back and CooperationLimitations• Unmatched, genetically unique subjects• Powerful ethical limitations• Patient Independence and Failure to Comply• Prior or Concomitant TreatmentVideo on Clinical Trials in Patients

A note on Experimental Cancer Therapy and National Health-Care Policy –

Keith Olbermann, MSNBC Countdown, February 9, 2010

Video News Item MSNBC, February 9 and 10, 2010:Keith Olbermann on Kyler Van Nocker, Neuroblastoma, and Coverage for

Experimental Therapy in Cancer.

See Next Slide for Link

Children, Cancer Therapy, and Beads, Syracuse NY, 2011http://centralny.ynn.com/content/top_stories/537100/a-creative-way-to-cope-with-cancer/ Beads4Cx18Mar11.doc

Obesity in the United States and the Future of Disease Incidence, Including CancerObesity and Medical Costs, ABSNEWS, Feb. 16, 2011ObesityABC16Feb11.doc

http://abcnews.go.com/WNT/video/obesity-crisis-threatens-health-care-system-americans-exercise-food-advice-tips-health-12935370

About Kuyler Van Nockerand

Neuroblastoma

Experimental FDA-Approved Cancer Therapy(FDA = Food and Drug Administration)

Who will pay for approved but experimental therapy?

(Played in Class: January 17, 2013)


The Ugly Truth of Pediatric Cancer

A Five-minute musical mosaic of childhood cancerGoogle the Title or

www.youtube.com/watch?v=7T3zQmBojAUDec 19, 2010 - Uploaded by KidsCancerChannel

This video shows the ugly side of pediatric cancer, and just a glimpse into the ... Ava's Cancer Storyby ...

More videos for The Ugly Story of Pediatric Cancer »

The Ugly Truth of Pediatric Cancer

A Five-minute musical mosaic of childhood cancerGoogle the Title or

www.youtube.com/watch?v=7T3zQmBojAUDec 19, 2010 - Uploaded by KidsCancerChannel

This video shows the ugly side of pediatric cancer, and just a glimpse into the ... Ava's Cancer Storyby ...

More videos for The Ugly Story of Pediatric Cancer »

Note: You may want to dispute the use of the word “Ugly” by those who compiled this montage of children with cancer. There is crushing sadness and heartache, but much of beauty shared by the children, their parents, and their brothers and sisters.

TPF Feb. 9, 2013

exam review: march 9, 2010 50113xm1review.ppt first hourly exam 100 pts updated: february 13, 2014...

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